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chr9:138,558,883-140,071,683

Best TWAS P=7.08e-15 · Best GWAS P=5.79e-13 conditioned to 0.148

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SNAPC4	0.06	0.04	lasso	2	0.05	9.0e-07	6.5	-5.9	3.2e-09	-0.87	0.53	0.45	FALSE
2	GTEx	Adrenal Gland	INPP5E	0.18	0.02	enet	23	0.10	2.2e-04	5.3	-6.1	9.1e-10	-0.62	0.15	0.36	FALSE
3	GTEx	Artery Tibial	SDCCAG3	0.05	0.00	lasso	4	0.00	2.2e-01	-7.2	-7.1	9.0e-13	-0.74	0.02	0.92	FALSE
4	GTEx	Brain Cerebellar Hemisphere	INPP5E	0.25	0.23	enet	6	0.17	3.4e-05	4.7	-5.2	2.3e-07	-0.76	0.30	0.57	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	INPP5E	0.27	0.05	enet	21	0.14	2.0e-05	4.7	-7.4	1.3e-13	-0.50	0.10	0.38	TRUE
6	GTEx	Cells Transformed fibroblasts	CARD9	0.10	0.01	enet	15	0.02	8.0e-03	-5.0	-6.6	3.6e-11	-0.54	0.05	0.87	FALSE
7	GTEx	Colon Sigmoid	INPP5E	0.22	0.10	lasso	3	0.01	1.6e-01	6.5	-6.6	3.6e-11	-0.95	0.02	0.96	FALSE
8	GTEx	Lung	CARD9	0.08	0.04	enet	6	0.04	2.5e-04	5.4	6.6	5.3e-11	0.87	0.02	0.97	FALSE
9	GTEx	Ovary	INPP5E	0.24	0.13	enet	11	0.15	1.9e-04	5.1	-5.5	4.4e-08	-0.79	0.08	0.51	FALSE
10	GTEx	Stomach	SEC16A	0.15	0.09	lasso	4	0.10	1.8e-05	4.0	-5.2	1.9e-07	-0.60	0.63	0.27	FALSE
11	GTEx	Thyroid	INPP5E	0.23	0.35	enet	16	0.37	8.2e-30	4.5	-5.7	1.2e-08	-0.81	0.86	0.14	FALSE
12	GTEx	Thyroid	PMPCA	0.10	0.05	enet	11	0.10	8.7e-08	4.0	-5.9	3.3e-09	-0.56	0.34	0.64	FALSE
13	GTEx	Whole Blood	SDCCAG3	0.07	0.03	enet	6	0.02	3.4e-03	4.0	-5.9	4.0e-09	-0.84	0.02	0.97	FALSE
14	GTEx	Whole Blood	CARD9	0.08	0.07	lasso	1	0.05	4.2e-05	6.9	6.9	4.5e-12	0.98	0.02	0.98	FALSE
15	METSIM	Adipose	CARD9	0.04	0.05	enet	6	0.06	5.9e-09	-7.2	7.8	7.1e-15	0.78	0.00	1.00	TRUE
16	YFS	Blood	CARD9	0.22	0.37	lasso	5	0.39	1.3e-137	7.2	7.2	6.6e-13	0.97	0.01	0.99	FALSE
17	YFS	Blood	PMPCA	0.03	0.01	lasso	5	0.02	2.7e-07	4.5	5.4	6.8e-08	0.79	0.06	0.94	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC16A	0.02	0.00	blup	69	0.01	1.0e-03	4.3	-6.0	2.1e-09	-0.66	0.06	0.70	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	INPP5E	0.11	0.08	lasso	2	0.08	3.4e-05	5.1	-5.1	3.0e-07	-0.71	0.14	0.14	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INPP5E	0.03	0.01	blup	54	0.01	1.1e-02	5.1	-5.4	6.9e-08	-0.81	0.01	0.69	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INPP5E	0.07	0.04	blup	54	0.07	6.0e-05	4.0	-6.0	2.5e-09	-0.82	0.05	0.84	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	5.9e-02	4.4	-5.8	7.7e-09	-0.85	0.03	0.60	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNAPC4	0.13	0.05	enet	7	0.06	1.7e-07	5.0	-6.1	1.1e-09	-0.66	0.74	0.12	FALSE
24	The Cancer Genome Atlas	Testicular Germ Cell Tumors	INPP5E	0.10	0.06	blup	54	0.08	8.1e-04	4.7	-5.6	2.7e-08	-0.83	0.04	0.69	FALSE