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chr17:37,137,299-39,048,774

Best TWAS P=1.89e-10 · Best GWAS P=9.23e-12 conditioned to 0.00996

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	6.7	6.4	1.9e-10	0.87	0.03	0.81	TRUE
2	GTEx	Breast Mammary Tissue	ORMDL3	0.17	0.04	enet	27	0.06	7.2e-04	5.2	5.3	1.4e-07	0.78	0.03	0.95	FALSE
3	GTEx	Colon Transverse	GSDMB	0.14	0.11	enet	18	0.12	2.0e-06	6.4	-5.7	1.0e-08	-0.91	0.05	0.94	FALSE
4	GTEx	Heart Atrial Appendage	PNMT	0.14	-0.01	lasso	8	0.00	5.3e-01	6.7	-6.0	1.6e-09	-0.85	0.04	0.82	FALSE
5	GTEx	Prostate	PGAP3	0.23	0.03	enet	26	0.06	1.6e-02	-3.6	-5.1	2.6e-07	-0.53	0.15	0.39	FALSE
6	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	-3.9	-5.7	1.6e-08	-0.77	0.06	0.86	FALSE
7	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	-4.9	-5.4	5.2e-08	-0.87	0.47	0.53	FALSE
8	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	-4.9	-5.5	4.6e-08	-0.88	0.42	0.57	FALSE
9	GTEx	Whole Blood	GSDMB	0.15	0.10	lasso	4	0.10	4.5e-09	-6.1	-6.2	4.3e-10	-0.94	0.11	0.89	FALSE
10	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	-4.9	-5.7	1.4e-08	-0.93	0.05	0.95	FALSE
11	METSIM	Adipose	RP11-387H17.4	0.04	0.00	bslmm	286	0.01	8.4e-03	-1.3	5.6	2.4e-08	0.71	0.03	0.68	FALSE
12	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	-5.6	-5.4	6.8e-08	-0.88	0.30	0.70	FALSE
13	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	6.7	5.7	1.4e-08	0.89	0.01	0.99	FALSE
14	NTR	Blood	ORMDL3	0.10	0.10	enet	24	0.12	4.4e-36	6.7	-5.2	2.0e-07	-0.91	0.01	0.99	FALSE
15	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	-6.3	-5.5	3.2e-08	-0.91	0.11	0.89	FALSE
16	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	-6.3	-5.4	8.1e-08	-0.88	0.12	0.88	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	6.8	-5.6	2.2e-08	-0.95	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	6.8	-5.7	1.2e-08	-0.94	0.01	0.80	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMB	0.05	0.07	blup	39	0.05	1.4e-06	-4.2	-5.2	1.7e-07	-0.86	0.23	0.77	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMB	0.02	0.01	blup	39	0.01	1.5e-02	-4.2	-5.9	4.6e-09	-0.97	0.02	0.84	FALSE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ORMDL3	0.03	0.04	lasso	2	0.04	2.9e-05	6.5	-5.6	2.7e-08	-0.96	0.02	0.97	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMB	0.14	0.16	lasso	4	0.14	2.4e-06	6.7	-5.9	3.6e-09	-0.99	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	6.0	-5.9	3.7e-09	-0.93	0.02	0.90	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	-4.4	-5.6	1.6e-08	-0.95	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	-4.4	-5.8	8.2e-09	-0.84	0.06	0.94	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	ORMDL3	0.08	0.13	blup	37	0.15	3.8e-14	-4.7	-5.6	1.8e-08	-0.90	0.30	0.70	FALSE