TWAS hub - STXBP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.3040	0.1020	2.9e-03	0.014	NA	0.059	NA	0.054	5.9e-02	NA	5.6e-04	NA	9.3e-04
2	GTEx	Breast Mammary Tissue (Female)	0.1343	0.0774	6.2e-02	-0.002	NA	-0.010	NA	-0.010	3.8e-01	NA	9.7e-01	NA	8.8e-01
3	GTEx	Cells Transformed fibroblasts	0.2190	0.0490	6.1e-09	0.050	NA	0.135	NA	0.142	1.2e-04	NA	2.8e-10	NA	8.4e-11
4	GTEx	Colon Transverse	0.2650	0.0690	1.3e-05	0.090	NA	0.068	NA	0.064	4.6e-05	NA	3.7e-04	NA	5.3e-04
5	GTEx	Esophagus Mucosa	0.1700	0.0420	3.0e-07	0.127	NA	0.144	NA	0.128	8.1e-09	NA	7.1e-10	NA	7.0e-09
6	GTEx	Skin Sun Exposed Lower leg	0.1120	0.0410	5.6e-04	0.040	NA	0.046	NA	0.033	2.8e-04	NA	1.0e-04	NA	9.0e-04
7	YFS	Blood	0.0174	0.0095	2.6e-02	-0.001	0.001	-0.001	0.001	-0.001	6.1e-01	0.16	9.8e-01	0.15	9.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Medication: Blood pressure	4.3	7.5	11.0	-0.7	-3.3	-3.2	-3.0	-3.1	-3.3	-1.3
Illnesses of siblings: Diabetes	3.8	4.6	8.9	1.5	2.2	2.4	3.0	2.7	1.8	0.2
Pack years adult smoking proportion	3.7	5.6	11.4	-1.1	-3.4	-2.2	-2.3	-3.1	-2.6	-1.0
Medication: Amlodipine	3.6	5.1	9.8	-0.9	-2.4	-2.9	-2.0	-2.7	-3.1	-0.5
LDL Cholesterol	3.2	5.0	30.5	0.8	0.5	-1.1	-5.5	0.6	-0.2	-1.5
Commuting to job workplace: Public transport	3.2	3.8	11.5	1.0	1.8	1.2	1.2	1.7	2.2	3.4
Major Depression (MDD)	3.1	3.7	8.1	-2.8	-2.3	-1.4	-1.8	-2.0	-1.9	-0.2
Blood White Count	3.1	22.8	43.2	4.6	5.4	4.3	6.6	4.8	2.7	4.1
Pack years of smoking	3.1	4.6	9.1	-0.7	-3.0	-2.0	-1.7	-2.8	-2.6	-0.9
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	11.0	-0.5	2.5	2.4	3.3	2.1	2.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	6.7	1.2	2.3	1.2	2.2	2.6	1.9	0.7
Long-standing illness, disability or infirmity	2.9	4.4	9.1	-0.7	-3.0	-2.9	-2.0	-2.3	-1.7	-0.6
Ever depressed for a whole week	2.9	3.6	9.5	-3.1	-1.5	-2.5	-2.1	-1.3	-0.7	-0.6
Had other major operations	2.8	3.5	12.8	3.6	1.4	1.6	1.4	1.6	1.5	0.6
Chronic bronchitis/emphysema (mother)	2.8	3.3	9.2	0.6	-1.2	-2.6	-1.5	-1.5	-1.0	-3.0
Eye problems/disorders: Cataract	2.8	3.3	5.3	0.2	1.6	2.3	1.8	2.1	1.7	2.0
Eye problems/disorders: None of the above	2.6	3.0	4.7	-0.7	-1.7	-1.7	-1.7	-2.1	-1.7	-2.2
Mean Putamen Volume	2.5	2.8	8.2	-0.3	-1.1	-0.7	-1.5	-1.1	-2.5	-2.9
Medication: Metformin	2.4	3.3	6.7	2.3	1.7	1.3	2.6	1.8	1.6	1.0
Chest pain or discomfort	2.1	3.1	7.8	0.5	1.9	2.8	1.2	1.6	0.8	2.3
Hypothyroidism (self reported)	2.0	4.7	11.6	0.3	-2.0	-2.2	-1.9	-1.9	-2.2	-3.4
Average weekly fortified wine intake	2.0	2.4	7.8	0.3	1.1	2.8	1.8	1.4	1.1	0.9
Cholesterol lowering medication	2.0	3.0	12.2	0.2	-0.9	-2.1	-3.5	-0.6	-0.1	-1.8
Crohns Disease (2017)	1.9	4.2	9.5	2.5	2.6	0.3	2.0	3.1	1.6	0.1
Bipolar Disorder (2011)	1.9	1.8	4.1	0.0	-2.0	-1.1	-1.6	-1.5	-1.1	-1.1
Mother’s age at death	1.9	2.3	5.1	1.9	1.3	2.1	2.2	1.0	0.5	0.3
Type 2 Diabetes (T2D) (2012)	1.8	2.1	3.1	-1.8	-1.8	-1.1	0.1	-1.5	-1.7	-1.5
High blood pressure	1.8	5.1	8.0	-0.6	-2.6	-2.2	-2.7	-1.8	-2.2	-2.8
Depression (self-reported)	1.8	2.2	4.6	-1.7	-2.1	-0.5	-1.4	-1.5	-0.3	-1.8
Medication: Gliclazide	1.8	2.0	5.2	1.7	0.6	1.5	1.1	1.4	2.3	0.7
Tinnitus: Yes, now most or all of the time	1.8	2.1	5.2	-2.3	-1.5	-0.8	-1.6	-0.7	-1.8	0.3
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.9	0.5	-1.9	-0.6	-1.4	-2.0	-1.6	-0.1
Townsend deprivation index at recruitment	1.7	2.3	4.2	-0.5	-2.0	-2.0	-2.0	-1.7	-0.8	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	6.5	0.6	1.0	2.5	1.0	1.5	0.7	1.5
Suffer from ‘nerves’	1.7	2.7	4.5	-0.4	-1.6	-1.6	-2.0	-1.9	-2.1	-1.1
Hypertension (Self-reported)	1.7	4.7	7.0	-0.5	-2.5	-2.3	-2.4	-1.8	-2.2	-2.6
Medication for cholesterol	1.7	2.5	6.8	-0.6	1.2	1.6	2.6	0.6	0.9	2.3
Pain all over the body in last month	1.6	1.8	5.5	-0.8	-1.6	-0.8	-2.4	-1.6	-0.5	-0.3
Medication: Simvastatin	1.6	2.3	9.2	-0.0	-1.5	-1.2	-3.0	-1.4	-0.9	-0.7
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.9	0.8	1.1	0.9	1.4	1.4	2.2	1.8
Hayfever, allergic rhinitis or eczema	1.5	3.3	5.5	-1.8	-2.0	-2.2	-1.4	-1.6	-2.4	-1.1
Medication: Cholesterol lowering	1.5	2.3	11.2	1.3	-1.1	-1.1	-3.4	-0.8	-0.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	5.0	-1.0	-2.2	-1.5	-1.4	-1.6	-1.1	-0.1
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.0	0.9	1.5	1.4	1.5	1.5	0.1	1.7
Medication: Aspirin	1.5	2.0	5.3	0.8	-1.4	-1.2	-2.3	-1.3	-1.6	0.2
Maternal smoking around birth	1.4	2.1	7.2	-0.0	-1.2	-2.7	-1.8	-0.9	-0.0	-1.3
Diabetes (self-reported)	1.4	2.1	5.2	2.0	1.0	0.6	2.3	1.2	1.5	0.2
Medication: Ramipril	1.4	1.8	4.0	-0.6	-1.3	-2.0	-1.8	-1.4	-1.1	-0.3
Asthma	1.4	2.7	5.7	0.6	1.7	1.6	1.2	1.8	2.4	1.6
Back pain experienced in last month	1.4	2.1	3.1	-1.7	-1.8	-1.6	-1.2	-1.2	-0.6	-1.6
Average weekly beer plus cider intake	1.4	2.0	3.1	-1.1	-1.8	-1.5	-1.1	-1.5	-1.0	-1.6
Schizophrenia (2014)	1.3	2.8	4.8	-1.0	-2.2	-2.1	-1.8	-1.7	-1.2	-1.2
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.8	-1.4	-1.4	-1.4	-0.6	-0.8	-1.4	-1.7
Length of working week for main job	1.3	1.5	3.9	0.0	0.4	1.3	0.6	1.6	1.2	2.0
Alzheimer’s Disease (including proxy)	1.2	1.8	5.1	-2.2	-1.9	-1.1	-1.1	-0.7	-0.8	-0.5
Number of treatments/medications taken	1.2	2.2	7.7	0.2	-1.7	-1.7	-2.8	-0.8	-0.5	-0.9
Medication: Levothyroxine sodium	1.2	2.0	6.3	1.1	-0.8	-1.3	-0.7	-1.1	-1.5	-2.5
Chronic bronchitis/emphysema (father)	1.2	1.4	6.7	0.8	-0.8	-0.7	-0.9	-0.4	-0.4	-2.6
Illnesses of siblings	1.2	1.7	7.0	-2.6	-1.1	-0.8	-0.8	-1.2	-1.1	0.1
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	3.6	-1.6	-1.5	-1.9	-1.2	-1.2	-1.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	3.3	0.0	1.6	1.0	1.8	1.3	0.2	1.2
Medication: Aspirin	1.2	1.5	4.7	0.8	-1.1	-1.0	-2.2	-1.0	-1.4	0.1
High cholesterol (Self-reported)	1.2	2.2	12.2	1.0	0.1	-0.9	-3.5	0.6	0.9	0.1
Vascular/heart problems diagnosed by doctor	1.2	3.1	5.4	0.2	2.0	2.0	2.3	1.2	1.9	1.9
Crohns Disease (2012)	1.1	1.8	3.3	1.8	1.8	-0.2	1.5	1.8	0.7	-0.6
Medication: Atenolol	1.1	1.4	4.6	-0.6	-1.1	-0.9	-1.5	-0.8	-0.6	-2.1
Number of live births	1.1	1.5	8.6	2.9	-0.3	-0.5	1.1	-0.3	0.5	-0.3
Noisy workplace	1.1	1.4	3.8	-2.0	-1.6	0.5	-1.0	-1.4	-0.5	0.6
Medication: Lansoprazole	1.1	1.2	2.9	-0.7	-1.6	-0.7	-1.7	-1.4	0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.8	2.2	0.9	1.7	0.3	1.0	0.9	1.4
Osteoporosis (self-reported)	1.1	1.3	3.1	-1.6	-1.8	-0.7	-1.2	-0.8	-0.8	-0.2
Osteoarthritis (self-reported)	1.1	1.5	3.0	0.3	-1.6	-1.2	-0.8	-0.5	1.5	-1.7
Smoking status: Current	1.1	1.7	3.6	-0.0	-1.8	-1.4	-0.8	-1.9	-1.0	-1.2
Medication: Lisinopril	1.1	1.5	2.2	-0.4	-1.4	-1.4	-1.4	-1.5	-1.0	-1.0
Medication: Atorvastatin	1.1	1.4	7.5	0.8	0.4	-0.9	-2.7	-0.0	0.1	-0.8
Risk taking	1.1	1.5	3.0	-0.0	1.7	1.6	1.5	1.3	0.6	1.1
Alcohol drinker status: Previous	1.1	1.2	3.0	-0.4	-0.7	-0.7	-1.7	-0.6	-1.3	-1.5
Chronotype (morning person)	1.0	2.3	4.6	1.1	-2.1	-1.5	-2.1	-1.8	-0.4	-0.5
Relative age voice broke	1.0	1.6	4.1	0.0	1.5	0.8	2.0	1.4	1.4	0.2
Lung cancer (father)	1.0	1.1	2.7	0.4	0.7	1.3	1.6	0.8	0.6	1.4
Had major operations	1.0	1.2	3.6	1.9	0.8	1.0	1.0	1.2	0.7	-0.2
Number of operations (self-reported)	1.0	1.5	3.4	1.9	1.2	1.0	1.1	1.3	0.7	0.9
Alzheimer’s Disease (in father)	0.9	1.0	2.5	-1.5	-0.0	-0.3	0.4	0.1	-1.4	1.6
Irritable Bowel Disease (IBD)	0.9	2.2	5.7	1.6	1.7	0.4	1.1	2.4	1.7	-0.1
Age at First Birth	0.9	1.4	5.0	0.6	1.5	0.8	2.2	1.0	0.4	0.2
High blood pressure (mother)	0.9	1.2	3.1	1.8	0.6	1.4	0.4	0.5	1.0	1.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.4	-1.6	-0.4	-1.3	-1.1	-0.4	0.3	1.2
Fluid intelligence score	0.9	1.9	5.7	-1.6	-1.3	-2.4	-1.1	-0.9	-1.0	-0.8
Illnesses of mother	0.9	1.1	3.0	-0.7	1.7	0.9	0.7	1.2	0.9	0.8
Shortness of breath walking on level ground	0.9	1.1	2.8	0.4	1.1	1.7	0.9	1.3	0.5	0.7
Migraine (self-reported)	0.9	1.2	4.1	-0.5	-0.8	-1.1	-0.7	-1.1	-2.0	-0.3
Medication: Seretide 50 evohaler	0.9	1.1	2.6	1.4	0.9	1.6	1.1	0.8	-0.1	-0.2
Supplements: Vitamin C	0.9	1.1	3.7	1.1	0.7	1.2	1.9	0.8	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	7.0	-0.4	0.8	0.9	0.9	1.3	1.3	2.6
Qualifications: nursing, teaching	0.9	1.4	3.4	-1.9	-1.4	-0.8	-1.1	-1.3	-0.7	-0.5
Asthma (self-reported)	0.9	1.8	3.9	0.4	1.5	1.2	0.9	1.6	2.0	1.3
Schizophrenia (2018)	0.8	1.7	3.9	-0.2	-1.7	-2.0	-1.6	-1.3	-1.1	-0.0
Coronary Artery Disease (CAD)	0.8	0.9	2.0	1.4	1.3	1.1	-0.0	1.1	0.6	0.1
HDL Cholesterol	0.8	1.3	3.8	-2.0	-1.9	-0.1	-0.7	-1.0	0.3	-0.1
Type 2 Diabetes (T2D) (2018)	0.8	1.5	6.6	2.6	0.1	-0.4	1.8	0.3	0.7	-0.1
Hearing difficulty/problems: Yes	0.8	1.2	3.9	0.1	1.4	1.1	2.0	1.2	-0.0	0.4
Current tobacco smoking	0.8	1.3	2.9	0.1	-1.7	-1.0	-0.8	-1.7	-0.7	-1.1
Birth weight	0.8	1.7	8.5	1.1	-0.3	-1.2	0.0	-0.2	-0.5	-2.9
Comparative body size at age 10	0.8	2.3	4.2	0.3	-2.0	-1.7	-1.0	-2.0	-1.7	-1.1
Number of children fathered	0.8	0.9	2.5	-0.0	-0.8	-1.1	-1.2	-1.6	0.3	-0.3
Leg pain on walking	0.8	1.1	3.6	0.5	0.1	1.0	0.9	0.6	1.1	1.9
Diabetes diagnosed by doctor	0.8	1.3	4.7	2.2	0.2	-0.3	1.7	0.7	0.8	0.2
Medication: Paracetamol	0.8	1.2	2.0	1.2	1.1	1.1	0.3	0.8	1.3	1.4
Myopia	0.8	1.1	4.0	2.0	-0.1	-1.7	0.5	-0.0	0.0	-0.9
Lupus	0.7	1.0	2.9	0.6	1.2	0.7	1.2	1.7	0.8	0.3
Systolic Blood Pressure	0.7	3.5	8.8	-0.5	-1.8	-2.0	-3.0	-1.4	-1.7	-1.9
Systolic blood pressure, automated reading	0.7	2.2	3.8	-1.3	-2.0	-1.4	-1.4	-1.1	-1.3	-1.8
Vitamin and mineral supplements	0.7	1.0	1.8	-0.9	-1.3	-0.3	-1.3	-1.4	-0.3	-0.9
Worrier / anxious feelings	0.7	1.4	2.6	0.0	0.9	0.9	1.4	1.1	1.6	1.6
Mouth/teeth dental problems: Dentures	0.7	1.2	3.1	-0.3	-1.7	-1.8	-0.9	-1.0	-0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.2	-0.6	-1.5	-0.5	-1.8	-0.7	-0.4	-0.5
Glaucoma (self-reported)	0.7	0.8	1.8	1.0	0.7	-0.7	0.6	0.6	1.3	-1.0
High blood pressure (siblings)	0.7	1.0	3.0	1.5	-0.7	-0.4	-1.0	-0.4	-0.5	-1.7
Emphysema/chronic bronchitis	0.7	0.8	2.0	1.4	0.9	0.7	0.8	1.1	0.6	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	4.2	-0.9	-0.3	0.3	-2.0	-0.5	-0.1	-0.2
Average weekly red wine intake	0.7	1.0	2.5	0.6	1.4	0.7	1.0	1.6	0.9	0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	3.9	0.5	0.2	0.7	0.8	0.1	0.8	2.0
Miserableness	0.7	1.2	5.1	0.8	0.6	0.7	0.2	0.8	2.2	1.0
Financial situation satisfaction	0.7	0.8	2.7	0.7	-0.7	-0.7	-1.6	-0.5	0.8	0.8
Eye problems/disorders: Glaucoma	0.7	0.8	1.1	0.8	1.0	-0.1	1.0	0.9	1.0	-1.0
Medication: Blood pressure	0.7	1.4	6.1	0.3	-0.8	-1.0	-1.0	-0.5	-0.6	-2.5
Pain experienced in last month	0.7	1.2	2.3	1.1	1.2	1.5	1.0	1.1	0.7	1.0
Bipolar Disorder or Schizophrenia	0.6	1.4	4.0	-0.1	-2.0	-1.4	-1.6	-1.2	-0.4	-0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.3	5.2	-2.3	-1.0	-0.9	-1.0	-0.5	-1.0	-0.4
Ovarian Cancer	0.6	0.8	2.6	-1.6	-1.2	0.3	-0.6	-1.1	0.1	-0.1
Primary Biliary Cirrhosis	0.6	0.9	2.7	0.4	1.0	-0.5	0.8	1.6	1.1	0.3
Allergy or Eczema	0.6	1.6	2.8	-1.4	-1.3	-1.6	-0.6	-1.0	-1.7	-0.8
Cardiovascular Disease	0.6	2.0	10.8	0.5	-0.8	-1.3	-3.3	-0.1	-0.5	-0.4
Average weekly spirits intake	0.6	0.7	1.5	0.4	0.8	-0.5	1.1	0.4	-1.2	0.9
Medication: Co-codamol	0.6	0.7	1.1	0.8	0.9	0.5	1.0	0.8	0.8	0.7
Multivitamins +/- minerals	0.6	0.8	2.6	0.8	1.2	-0.1	0.5	1.6	0.2	0.4
Pulse rate	0.6	1.0	3.5	1.9	0.7	-0.7	-0.7	1.1	1.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.4	-0.8	1.2	0.5	0.6	1.0	1.0	0.6
Hair/balding pattern: Pattern 4	0.6	1.4	6.3	1.3	-0.1	-0.2	-0.2	0.7	1.0	-2.5
Loud music exposure frequency	0.6	0.7	1.6	0.8	1.0	0.7	0.3	1.3	0.9	0.3
Qualifications: College or University degree	0.6	1.9	5.8	1.6	0.8	1.6	0.9	1.0	2.4	0.1
Angina (self-reported)	0.6	0.8	2.4	0.5	1.2	0.6	-0.5	0.8	-0.2	1.5
Medication: Allopurinol	0.6	0.8	2.5	1.6	0.1	0.9	0.5	0.2	0.1	-1.4
Ever had bowel cancer screening	0.6	0.8	3.6	1.9	0.6	-0.0	1.0	0.5	0.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.5	0.6	0.5	-0.6	1.6	0.6	-0.8	0.5
Commuting to job workplace: Walk	0.6	0.6	3.2	-0.2	-0.6	0.1	-0.8	-0.2	-0.0	1.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.7	1.6	-0.1	0.6	0.4	0.2	1.3	0.5
Heart disease (siblings)	0.6	0.7	2.2	1.5	0.6	-1.1	-0.2	0.5	0.9	-0.3
Breast Cancer	0.5	1.3	2.8	-1.5	-0.9	-0.3	-0.9	-1.7	-1.5	-0.1
Prostate Cancer	0.5	0.6	2.1	-0.5	-0.3	-1.2	-0.3	-0.1	-1.4	0.6
Rheumatoid Arthritis	0.5	0.7	1.3	0.6	1.1	1.0	0.7	1.1	0.9	-0.1
Blood Eosinophil Count	0.5	4.0	8.5	1.7	2.3	1.9	2.9	1.7	-0.2	2.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.6	-0.7	-0.8	-1.2	-1.2	-0.5	-0.6	-0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-0.3	-1.1	-0.7	-1.1	-0.4	0.5	-0.7
Angina	0.5	0.7	2.6	0.6	0.9	0.5	-0.6	0.6	-0.2	1.6
Taking other prescription medications	0.5	0.7	1.8	0.5	-1.2	-0.7	-1.4	-0.9	-0.4	0.2
Alcohol usually taken with meals	0.5	0.8	2.0	0.3	1.2	0.5	0.1	1.1	1.4	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.6	0.9	-0.4	1.0	-1.6	0.3	1.1	0.1
Qualifications: None of the above	0.5	1.0	3.0	1.4	0.5	1.1	1.7	0.5	-0.4	0.5
Prospective memory result	0.5	0.6	2.5	0.0	-0.8	0.3	0.2	-0.7	-0.2	-1.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.9	1.7	-0.1	0.6	0.8	0.3	0.4	-0.1
Exposure to tobacco smoke at home	0.5	0.5	1.5	1.2	-0.9	-0.3	-0.0	-1.1	0.1	0.1
Worry too long after embarrassment	0.5	0.9	2.0	-0.3	-1.0	-0.9	-0.8	-1.0	-0.7	-1.4
Medication for pain relief, constipation, heartburn	0.5	0.9	3.1	-0.4	0.6	1.1	1.8	0.5	0.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.5	-1.0	0.2	-1.6	-0.6	0.2	-0.1	0.8
Smoking status: Previous	0.5	0.8	1.2	0.3	1.0	-0.6	0.8	1.1	0.9	1.1
Loneliness, isolation	0.5	0.7	2.0	0.9	0.1	0.9	1.1	0.6	1.4	0.0
Breast cancer (self-reported)	0.5	0.6	1.4	0.6	0.7	0.2	-0.0	1.2	1.1	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	0.2	-1.1	-1.4	-0.9	-0.6	-1.3	-0.5
Age started oral contraceptive pill	0.5	0.6	2.8	0.6	0.3	0.9	-0.3	-0.4	-0.4	-1.7
Unable to work because of sickness or disability	0.5	0.6	2.0	-1.4	0.4	1.4	0.3	0.6	0.2	0.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	4.5	-2.1	-1.0	-0.8	-1.0	-0.6	-0.4	-0.3
Alzheimer’s Disease (in mother)	0.4	0.4	1.5	-1.2	-0.8	-0.3	-0.5	0.2	0.7	-0.0
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	-0.9	0.1	-0.6	1.5	-0.1	-0.4	-0.6
HbA1C	0.4	0.5	1.1	-0.1	-0.8	-1.1	-1.1	-0.1	-0.2	-0.6
Waist Hip Ratio (WHR)	0.4	1.9	3.3	1.3	1.1	1.4	0.9	1.7	1.8	-1.1
Tanning	0.4	4.7	6.4	-2.4	-2.5	-2.1	-2.2	-2.3	-2.4	-0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	-0.5	-0.6	1.2	-0.3	0.1	1.3	0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.4	1.5	-0.1	-0.1	-1.2	-0.3	-0.1	-0.3	-1.2
Medication for hormone replacement therapy	0.4	0.5	2.1	0.2	0.2	-0.6	-0.4	-0.3	-1.5	0.7
Diabetes (mother)	0.4	0.5	1.2	0.5	-1.1	-0.1	1.0	-0.6	0.2	-0.8
Impedance of leg (right)	0.4	2.0	4.8	-1.0	1.9	1.7	-0.4	0.8	1.1	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.9	-0.3	-0.9	-0.4	-1.4	-0.2	0.4	0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.8	1.4	0.1	-0.7	-0.1	0.2	0.7	0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	0.1	0.9	0.8	1.0	0.8	-0.4	-0.6
Nervous feelings	0.4	0.7	2.5	0.2	-1.1	-0.6	-1.6	-0.8	-0.1	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	2.3	-0.5	-0.7	0.1	-0.5	-0.3	-0.1	1.5
Impedance of arm (right)	0.4	1.9	2.9	-1.5	1.7	1.5	0.8	1.1	1.1	1.7
Impedance of arm (left)	0.4	2.1	4.0	-2.0	1.7	1.4	0.9	1.1	0.9	1.7
Peak expiratory flow (PEF)	0.4	1.0	2.3	-0.4	1.4	0.3	1.0	1.5	0.1	1.1
Pulse wave reflection index	0.4	0.5	1.9	1.4	-0.1	0.4	0.7	-0.1	0.6	-0.3
Blood clot in the leg (DVT)	0.4	0.6	1.9	1.4	-0.1	0.6	0.4	0.2	1.1	0.5
Exposure to tobacco smoke outside home	0.4	0.5	1.2	-0.2	-1.1	-0.3	-0.5	-0.5	-1.0	0.9
Pulse wave peak to peak time	0.4	0.5	2.5	-1.6	0.3	-0.4	-0.5	-0.1	-0.2	0.2
Medication: Ibuprofen	0.4	0.4	1.5	-0.3	1.2	0.2	0.6	0.9	0.6	0.1
Medication: Omeprazole	0.4	0.5	1.2	-0.3	-0.7	-0.9	-1.1	-0.8	-0.5	0.3
Number of full sisters	0.4	0.5	1.3	1.1	-0.4	-0.1	-0.1	-0.8	-1.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.0	0.2	-0.8	-0.8	-0.5	-1.0	-0.5	-0.4
Illnesses of father: Heart disease	0.4	0.6	1.5	1.2	0.4	-0.6	-1.2	0.6	0.2	-0.5
Mineral and other dietary supplements	0.4	0.6	2.2	1.1	0.3	0.7	0.0	0.1	0.6	1.5
Ever taken oral contraceptive pill	0.4	0.4	1.2	-1.1	-0.8	-0.6	-0.5	-0.5	-0.1	-0.5
Medication: Bendroflumethiazide	0.4	0.6	2.9	-0.6	-0.7	-0.8	0.1	0.2	-0.1	-1.7
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.8	-0.7	-0.7	-0.6	-0.7	-1.1	-0.2
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	0.8	-0.4	0.9	-0.8	0.2	0.2	-0.8
Impedance of whole body	0.4	2.1	4.6	-2.1	1.8	1.5	0.2	0.9	0.8	1.9
Depressed Affect (Nagel 2018)	0.3	0.7	1.7	1.1	0.5	1.0	0.8	0.3	1.3	0.4
Depression (Nagel 2018)	0.3	0.5	1.4	-0.5	-1.2	0.7	-0.6	-0.2	0.5	0.8
Ulcerative Colitis (UC)	0.3	0.6	2.2	-0.1	0.5	0.3	-0.0	1.2	1.5	-0.1
Reaction Time	0.3	0.6	1.9	-1.0	-0.5	-0.4	-0.4	-0.5	-0.7	-1.4
Neuroticism (2016)	0.3	0.4	0.9	0.6	-0.7	-0.9	-0.4	-0.6	-0.4	-0.6
Ulcerative Colitis	0.3	0.5	1.1	0.8	1.0	0.8	0.3	0.8	0.6	-0.1
Heel T-Score	0.3	2.2	4.8	-0.7	-1.0	-1.8	-0.6	-1.8	-2.2	-1.5
Lung FEV1/FVC ratio	0.3	1.6	3.8	1.2	1.9	0.6	1.1	1.7	0.2	1.1
Sensitivity / hurt feelings	0.3	0.6	1.7	-1.3	0.0	-1.0	0.4	0.2	-0.1	-1.1
Supplements: Zinc	0.3	0.3	1.5	0.5	0.3	-0.4	0.1	-0.3	-0.1	-1.2
Diabetes (father)	0.3	0.4	0.9	-0.2	-0.5	0.1	0.9	-0.5	-0.8	-0.9
Supplements: Glucosamine	0.3	0.4	0.8	-0.9	0.0	-0.7	0.8	-0.1	0.6	-0.8
Impedance of leg (left)	0.3	1.5	3.0	-1.4	1.3	1.5	-0.9	0.3	0.6	1.7
Past tobacco smoking	0.3	0.6	1.7	-0.7	-0.3	1.2	-0.4	-0.4	-0.6	-1.3
Financial difficulties in last 2 years	0.3	0.3	0.8	-0.9	0.1	0.1	-0.1	0.7	0.6	0.8
Neuroticism score	0.3	0.6	1.1	-0.7	-0.9	-0.6	-1.0	-1.1	-0.1	-0.8
Hip circumference	0.3	1.2	3.0	-0.7	-1.2	-1.7	-0.0	-1.0	-1.6	0.0
Time employed in main current job	0.3	0.4	1.4	-0.2	-0.3	-0.7	-0.4	0.2	1.2	-0.6
Alcohol intake versus 10 years previously	0.3	0.5	1.4	-0.7	-0.7	-1.2	-0.2	-0.6	-0.6	0.7
Father’s age at death	0.3	0.3	0.6	-0.2	-0.3	-0.5	0.8	-0.7	-0.7	-0.7
Standing height	0.3	2.9	7.2	0.1	1.4	1.2	2.7	1.4	1.9	1.9
Breastfed as a baby	0.3	0.3	1.4	-0.3	-0.3	-0.5	0.3	-0.2	-1.2	-0.6
Tense / ‘highly strung’	0.3	0.4	1.8	1.3	0.3	0.4	-0.4	0.4	0.8	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-0.9	0.3	-0.1	0.3	0.4	1.1	0.5
Medication: Paracetamol	0.3	0.5	2.0	0.6	0.5	0.5	0.0	0.4	0.7	1.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.8	-0.2	-0.6	-0.7	-0.4	-0.5	-0.6	-1.7
Wheeze or whistling in the chest in last year	0.3	0.6	3.4	0.1	-0.0	0.2	0.6	0.0	0.3	1.8
Age at first live birth	0.3	0.5	1.7	-1.2	0.6	1.3	-0.2	0.2	-0.3	-0.1
Neck or shoulder pain in last month	0.3	0.4	1.5	-0.3	1.2	-0.4	0.0	0.7	-0.6	-0.2
Mean time to correctly identify matches	0.3	0.5	2.2	0.4	0.3	-0.0	0.9	0.4	-0.5	-1.5
Pulse rate, automated reading	0.3	0.9	3.5	0.9	-0.3	-1.4	-1.9	0.2	0.0	0.3
Overall health rating	0.3	0.7	1.2	1.1	-0.9	-1.0	-0.6	-0.4	-0.8	-0.6
Age at last live birth	0.3	0.4	1.4	-0.2	0.1	0.6	-1.2	-0.2	-1.0	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.7	0.3	0.5	0.1	0.3	0.3	-1.3	0.1
Mood swings	0.3	0.6	1.6	0.5	0.8	1.3	0.9	0.3	0.4	0.6
Friendships satisfaction	0.3	0.4	0.8	0.6	-0.3	0.8	-0.6	0.3	0.6	0.9
Guilty feelings	0.3	0.4	1.8	-0.3	0.0	0.2	-0.7	0.2	1.4	-0.6
Wears glasses or contact lenses	0.3	0.3	0.9	-0.4	0.1	-0.6	-0.2	0.9	-0.8	0.2
Hearing aid user	0.3	0.4	0.8	-0.4	-0.9	-0.5	-0.5	-0.4	-0.9	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.5	-0.4	-0.7	-0.7	0.2	-0.6	-0.5	0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.6	-1.2	0.2	0.3	0.5	0.4	-0.3	-0.3
Illnesses of father: High blood pressure	0.3	0.4	1.4	1.2	-0.6	0.3	-0.5	-0.4	-0.4	-0.5
Ever smoked	0.3	0.5	1.5	0.8	0.2	-0.7	0.7	0.1	-0.2	1.2
Leg fat percentage (left)	0.3	1.2	2.4	-1.0	-0.8	-1.5	-0.6	-0.7	-1.6	-1.1
Diastolic blood pressure, automated reading	0.3	1.1	2.1	-1.4	-1.3	-1.4	-1.0	-0.5	0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	-0.7	-0.2	-0.9	-0.9	-0.4	-0.4	-0.2
Supplements: Calcium	0.3	0.3	0.9	-0.5	-0.5	-0.7	-0.9	-0.5	-0.2	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.1	0.5	1.4	0.1	0.1	0.6	0.1	0.5
Bipolar Disorder (2018)	0.2	0.3	1.2	0.0	-1.1	0.3	-0.6	-0.5	0.3	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	1.2	0.4	0.0	-1.1	-0.4	-0.1	0.3	-0.2
BMI	0.2	0.9	3.3	1.8	0.2	-0.4	1.4	0.5	-0.1	0.6
Respiratory disease	0.2	0.4	0.6	0.5	0.7	0.7	0.8	0.8	-0.2	0.6
Lung FVC	0.2	0.8	1.7	-0.9	-1.0	-1.3	-0.6	-1.0	-0.2	-0.7
Hand grip strength (left)	0.2	0.6	2.0	-1.4	-0.8	-0.5	-0.6	-0.9	0.2	0.3
Hand grip strength (right)	0.2	0.6	1.5	-1.2	-0.8	-0.9	-0.6	-0.7	-0.4	0.6
Fed-up feelings	0.2	0.3	0.8	-0.0	-0.9	-0.2	-0.7	-0.8	0.1	0.6
Age when periods started (menarche)	0.2	0.6	1.6	-1.3	0.7	0.7	0.7	0.3	0.7	-0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.7	-0.1	-0.8	-0.4	0.1	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	1.3	0.7	0.0	1.1	0.1	-0.1	-0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.7	0.8	0.3	0.1	-0.8	0.3	0.0	-0.0
Stomach or abdominal pain in last month	0.2	0.3	1.0	-0.1	-0.1	0.1	0.7	0.5	0.2	1.0
Body mass index (BMI)	0.2	0.9	2.5	0.1	-1.2	-1.6	-0.2	-0.5	-0.9	-1.0
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.8	0.3	-0.2	0.7	0.7	-0.0	-0.1
Heart attack	0.2	0.3	1.4	0.3	1.2	-0.3	-0.1	0.3	0.0	0.3
Allergy	0.2	0.5	0.8	-0.1	0.8	0.9	0.8	0.6	0.8	0.1
Arm fat percentage (right)	0.2	0.6	1.8	-1.0	-0.7	-1.3	0.2	-0.2	-1.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.7	0.3	-0.6	0.6	-1.3	0.1	0.2	0.0
Falls in the last year	0.2	0.2	1.1	1.1	0.1	-0.3	0.0	-0.0	-0.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.9	-0.4	1.4	0.0	0.2	1.2	0.9	0.4
Happiness	0.2	0.2	0.6	-0.4	-0.2	0.2	-0.7	0.5	0.8	0.2
Birth weight of first child	0.2	0.3	0.6	0.8	0.5	0.8	0.7	0.2	0.2	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.8	0.3	0.6	-0.0	0.4	-0.1	0.7
Headache pain in last month	0.2	0.3	0.7	0.3	0.6	0.5	0.8	0.8	0.0	-0.0
Gout (self-reported)	0.2	0.3	0.9	0.6	0.5	0.3	0.5	0.3	-0.2	-0.9
Number of full brothers	0.2	0.3	0.5	0.1	0.7	0.4	0.6	0.4	-0.5	0.7
Health satisfaction	0.2	0.2	0.5	0.3	0.1	0.7	-0.7	0.4	0.4	-0.5
Alcohol intake frequency.	0.2	0.4	1.9	-0.2	-0.6	-0.4	-1.4	-0.1	0.4	-0.1
Comparative height size at age 10	0.2	0.9	2.9	1.1	0.3	0.2	1.7	0.5	0.8	1.1
Family relationship satisfaction	0.2	0.2	0.7	-0.0	-0.2	0.8	-0.7	0.2	0.5	-0.3
Arm fat percentage (left)	0.2	0.7	1.6	-1.2	-0.6	-1.3	0.3	-0.1	-0.9	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.6	-0.4	-0.3	0.2	0.1	0.7	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	0.2	0.3	-0.2	0.5	0.5	-0.4	0.9
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.4	-0.1	0.7	0.6	-0.1	0.4	0.8
Alcohol drinker status: Never	0.2	0.2	0.9	1.0	-0.0	0.3	0.5	0.3	0.4	0.0
Irritability	0.2	0.3	0.6	-0.7	-0.8	-0.6	-0.6	-0.3	0.2	-0.3
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.6	0.4	-0.5	0.5	-0.3	-0.8	0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.9	-0.0	0.2	-0.0	0.0	0.8	-0.5
Worry (Nagel 2018)	0.1	0.3	0.6	0.8	-0.5	-0.1	-0.7	-0.6	0.2	-0.7
Fasting Glucose	0.1	0.1	0.2	-0.5	-0.4	0.1	0.4	-0.1	-0.2	0.2
Triglycerides	0.1	0.2	0.9	0.3	0.2	-0.1	0.2	-0.7	-0.9	-0.4
Blood Platelet Count	0.1	1.7	3.3	0.6	1.2	1.5	1.6	1.0	1.0	1.8
Blood Red Count	0.1	1.1	3.5	1.4	1.0	-0.1	1.9	1.0	0.4	-0.0
Height	0.1	1.4	3.0	-1.7	-1.6	-1.2	-0.4	-1.4	-0.3	-0.6
Smoking Status	0.1	0.3	1.0	0.2	-0.1	-1.0	0.7	-0.3	-0.6	0.2
Neuroticism	0.1	0.1	0.6	0.4	-0.2	0.2	0.1	-0.1	0.1	-0.8
Leg fat-free mass (left)	0.1	0.5	1.5	0.4	-0.6	-1.2	1.2	-0.0	0.2	-0.0
Trunk fat percentage	0.1	0.5	1.9	-1.4	0.0	-0.7	0.8	0.2	-0.3	-0.0
Serious illness, injury or assault to yourself	0.1	0.2	0.4	0.7	0.2	0.4	-0.6	0.3	-0.3	0.1
Sitting height	0.1	0.5	2.1	-0.2	0.9	-0.0	1.5	0.8	0.5	0.2
Leg predicted mass (left)	0.1	0.5	1.5	0.5	-0.6	-1.2	1.2	-0.0	0.3	0.0
Trunk fat mass	0.1	0.4	1.1	-1.0	-0.1	-0.9	1.0	0.1	-0.4	-0.2
Waist circumference	0.1	0.5	1.2	0.4	-0.9	-1.1	0.4	-0.1	-0.7	-1.0
Number of incorrect matches in round	0.1	0.2	0.6	-0.8	0.2	0.1	-0.1	0.1	0.2	0.7
Had menopause	0.1	0.2	0.6	0.4	-0.4	0.1	0.8	-0.0	0.5	0.3
Forced vital capacity (FVC)	0.1	0.5	1.2	-0.5	1.1	-0.1	0.3	0.9	1.1	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.5	0.3	-0.5	0.5	-0.2	-0.4	-0.6
Mouth/teeth dental problems	0.1	0.2	0.5	-0.6	0.7	0.1	-0.1	0.0	0.3	-0.7
Weight	0.1	0.3	1.1	0.0	-0.6	-1.1	0.9	-0.0	-0.1	-0.2
Trunk fat-free mass	0.1	0.4	1.2	0.9	-0.5	-0.6	1.1	0.0	0.2	0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	0.7	0.3	-0.1	0.1	0.3	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.0	-0.3	-0.7	-0.4	0.0	0.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	1.0	-0.1	1.0	-0.4	-0.1	0.5	0.3	0.1
Arm fat mass (right)	0.1	0.3	1.0	-0.4	-0.4	-1.0	0.8	0.2	-0.4	-0.3
Trunk predicted mass	0.1	0.4	1.1	0.9	-0.5	-0.6	1.1	-0.1	0.1	0.2
Body fat percentage	0.1	0.5	1.7	-1.3	-0.4	-1.1	0.2	-0.1	-0.7	-0.3
Leg fat percentage (right)	0.1	0.5	1.5	-0.6	-0.2	-1.2	-0.1	-0.3	-1.1	-0.5
Arm fat-free mass (right)	0.1	0.3	0.7	0.6	-0.7	-0.8	0.7	-0.2	0.4	0.1
Heart disease (mother)	0.1	0.2	0.9	0.1	0.1	-0.1	-1.0	0.2	0.4	-0.4
Whole body fat mass	0.1	0.4	1.5	-0.7	-0.5	-1.2	0.6	-0.1	-0.6	-0.4
Leg fat mass (right)	0.1	0.3	1.3	-0.2	-0.4	-1.1	0.4	-0.2	-0.7	-0.3
Arm predicted mass (right)	0.1	0.3	0.8	0.5	-0.3	-0.5	0.9	0.2	0.7	0.5
Knee pain experienced in last month	0.1	0.2	0.7	-0.5	-0.5	-0.2	-0.3	0.2	0.8	0.1
Whole body fat-free mass	0.1	0.4	1.1	0.8	-0.7	-0.9	1.1	-0.1	0.2	0.1
Leg fat-free mass (right)	0.1	0.5	1.6	0.3	-1.0	-1.3	0.9	-0.3	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.9	0.1	0.3	-0.7	-1.0	-0.2	-0.3	-0.5
Whole body water mass	0.1	0.5	1.6	0.8	-0.5	-0.7	1.3	0.1	0.4	0.2
Leg predicted mass (right)	0.1	0.5	1.6	0.2	-0.9	-1.3	0.9	-0.3	0.0	-0.2
Arm fat mass (left)	0.1	0.3	0.9	-0.5	-0.4	-1.0	0.9	0.2	-0.5	-0.2
Basal metabolic rate	0.1	0.4	1.4	0.5	-0.5	-0.9	1.2	0.0	0.2	0.1
Arm fat-free mass (left)	0.1	0.5	0.9	0.9	-0.7	-1.0	0.8	-0.1	0.3	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.4	-0.3	0.2	0.4	-0.1	-0.6	0.4
Leg fat mass (left)	0.1	0.6	1.8	-0.5	-0.8	-1.4	0.1	-0.4	-0.9	-0.6
Arm predicted mass (left)	0.1	0.5	1.6	1.0	-0.3	-0.6	1.3	0.2	0.6	0.4
Hair Pigment	0.0	0.2	0.7	-0.5	0.6	0.0	0.9	0.4	-0.0	-0.5
Relative age of first facial hair	0.0	0.1	0.3	0.2	0.1	0.1	0.5	0.1	0.3	0.1
Severe depression (siblings)	0.0	0.0	0.1	0.0	0.0	0.1	0.1	-0.0	-0.3	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.1	0.4	-0.3	0.6	-0.6	-0.2	0.1	0.3	-0.0

Hub : Genes

STXBP3

Models

Trait associations