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chr1:149,672,809-151,793,174

Best TWAS P=1.3e-18 · Best GWAS P=2.29e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Esophagus Muscularis	MRPS21	0.14	0.15	enet	13	0.16	7.2e-10	-8.24	8.8	1.3e-18	-0.47	0.71	0.29	TRUE
29	GTEx	Ovary	MRPS21	0.29	0.07	lasso	3	0.06	1.6e-02	-8.06	7.9	2.5e-15	-0.41	0.07	0.14	TRUE
12	GTEx	Cells Transformed fibroblasts	RP11-54A4.2	0.08	0.01	lasso	8	0.02	1.8e-02	-7.93	7.9	3.0e-15	-0.39	0.47	0.18	TRUE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRPS21	0.13	0.13	enet	10	0.13	1.7e-14	-7.57	7.4	1.2e-13	-0.43	0.03	0.97	TRUE
11	GTEx	Cells Transformed fibroblasts	MRPS21	0.12	0.05	enet	9	0.08	2.6e-06	-7.57	7.1	1.3e-12	-0.46	0.69	0.25	TRUE
39	METSIM	Adipose	ADAMTSL4	0.11	0.03	enet	14	0.05	1.9e-08	4.06	-5.5	3.4e-08	0.11	0.95	0.00	TRUE
1	GTEx	Adipose Subcutaneous	SV2A	0.08	0.00	lasso	5	0.02	5.2e-03	0.72	-5.5	4.5e-08	0.20	0.02	0.60	TRUE
44	YFS	Blood	PRUNE	0.05	0.00	enet	33	0.02	5.8e-06	2.31	5.2	1.7e-07	-0.40	0.02	0.79	TRUE
41	METSIM	Adipose	MRPS21	0.06	0.07	lasso	7	0.06	5.1e-10	-8.08	8.2	2.6e-16	-0.45	0.74	0.26	FALSE
37	GTEx	Thyroid	MRPS21	0.21	0.22	lasso	7	0.24	2.2e-18	-8.03	8.2	3.3e-16	-0.45	0.74	0.26	FALSE
24	GTEx	Muscle Skeletal	TARS2	0.11	0.09	lasso	1	0.07	8.5e-08	-8.12	-8.1	4.7e-16	0.43	0.78	0.22	FALSE
3	GTEx	Artery Aorta	MRPS21	0.09	0.08	lasso	4	0.06	5.1e-04	-8.18	8.1	7.1e-16	-0.46	0.24	0.10	FALSE
21	GTEx	Heart Atrial Appendage	MRPS21	0.16	0.08	lasso	11	0.11	9.3e-06	-8.03	7.9	2.3e-15	-0.39	0.68	0.20	FALSE
22	GTEx	Heart Left Ventricle	MRPS21	0.15	0.09	lasso	6	0.10	7.3e-06	-8.19	7.9	2.6e-15	-0.40	0.57	0.28	FALSE
23	GTEx	Lung	MRPS21	0.19	0.09	enet	12	0.17	4.3e-13	-8.19	7.9	3.0e-15	-0.39	0.72	0.28	FALSE
28	GTEx	Nerve Tibial	MRPS21	0.13	0.02	lasso	9	0.02	9.4e-03	-8.06	7.9	3.0e-15	-0.42	0.42	0.40	FALSE
25	GTEx	Muscle Skeletal	MRPS21	0.06	0.02	lasso	7	0.02	4.6e-03	-8.18	7.8	4.7e-15	-0.39	0.38	0.16	FALSE
30	GTEx	Pituitary	MRPS21	0.37	0.36	enet	19	0.37	2.7e-10	-8.24	7.8	5.8e-15	-0.45	0.71	0.27	FALSE
38	GTEx	Uterus	MRPS21	0.28	0.03	lasso	10	0.05	3.2e-02	-8.24	7.7	1.2e-14	-0.36	0.07	0.07	FALSE
8	GTEx	Breast Mammary Tissue	MRPS21	0.12	0.04	lasso	4	0.06	7.6e-04	-8.19	7.6	2.5e-14	-0.38	0.29	0.20	FALSE
34	GTEx	Skin Sun Exposed Lower leg	MRPS21	0.07	0.06	enet	9	0.08	1.6e-07	-8.03	7.6	4.0e-14	-0.47	0.71	0.26	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	MRPS21	0.09	0.06	lasso	3	0.06	2.6e-04	-5.37	7.2	7.5e-13	-0.29	0.34	0.22	FALSE
10	GTEx	Cells Transformed fibroblasts	ADAMTSL4	0.08	0.01	lasso	4	0.01	2.6e-02	-4.69	7.1	1.5e-12	-0.26	0.39	0.20	FALSE
40	METSIM	Adipose	ENSA	0.05	0.00	bslmm	291	0.02	1.5e-03	-7.92	-7.0	3.5e-12	0.30	0.30	0.10	FALSE
35	GTEx	Spleen	MRPS21	0.23	0.02	enet	27	0.07	7.8e-03	-8.19	6.7	2.2e-11	-0.31	0.11	0.07	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	MRPS21	0.07	0.01	blup	15	0.02	1.7e-03	4.55	6.7	2.8e-11	-0.36	0.00	0.97	FALSE
15	GTEx	Esophagus Mucosa	ECM1	0.14	0.10	lasso	10	0.12	2.2e-08	-5.37	6.6	3.7e-11	-0.23	0.82	0.18	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	ADAMTSL4	0.02	0.00	blup	33	0.02	4.7e-03	-8.08	6.6	3.9e-11	-0.59	0.01	0.63	FALSE
36	GTEx	Testis	MRPS21	0.26	0.15	lasso	12	0.15	2.4e-07	4.64	6.5	6.4e-11	-0.30	0.97	0.01	FALSE
14	GTEx	Colon Transverse	SV2A	0.09	0.00	lasso	9	0.00	2.2e-01	3.63	-6.4	1.4e-10	0.39	0.05	0.07	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1orf54	0.06	0.02	blup	17	0.03	2.5e-03	5.19	-6.4	1.9e-10	0.34	0.00	0.85	FALSE
9	GTEx	Breast Mammary Tissue (Female)	MRPS21	0.18	0.09	lasso	6	0.12	1.9e-04	4.67	6.3	2.7e-10	-0.30	0.21	0.11	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MRPS21	0.14	0.08	enet	14	0.08	2.0e-05	-8.08	6.3	2.7e-10	-0.28	0.00	1.00	FALSE
43	NTR	Blood	MRPS21	0.17	0.10	blup	236	0.12	2.1e-36	2.60	6.3	2.9e-10	-0.29	1.00	0.00	FALSE
17	GTEx	Esophagus Mucosa	MRPS21	0.09	0.06	lasso	2	0.05	3.0e-04	4.74	6.2	4.0e-10	-0.29	0.40	0.05	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ADAMTSL4	0.11	0.07	lasso	4	0.07	1.2e-08	-5.37	6.2	5.9e-10	-0.25	0.57	0.42	FALSE
42	METSIM	Adipose	TARS2	0.09	0.09	enet	8	0.08	1.6e-12	5.67	-6.0	2.0e-09	0.39	1.00	0.00	FALSE
26	GTEx	Nerve Tibial	ARNT	0.25	0.08	enet	23	0.17	4.3e-12	3.34	6.0	2.2e-09	-0.78	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADAMTSL4	0.12	0.09	lasso	5	0.09	6.0e-06	-5.37	6.0	2.2e-09	-0.19	0.16	0.30	FALSE
54	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MRPS21	0.04	0.03	blup	15	0.04	4.0e-05	-7.57	6.0	2.7e-09	-0.40	0.00	0.94	FALSE
2	GTEx	Artery Aorta	ADAMTSL4	0.17	0.14	lasso	4	0.10	3.7e-06	-5.37	5.9	3.1e-09	-0.20	0.91	0.03	FALSE
19	GTEx	Esophagus Muscularis	HIST2H2AA3	0.18	0.02	lasso	4	0.03	5.4e-03	3.63	-5.9	3.3e-09	0.37	0.05	0.05	FALSE
18	GTEx	Esophagus Mucosa	RP11-54A4.2	0.35	0.33	enet	15	0.34	1.6e-23	-5.37	5.9	3.4e-09	-0.17	1.00	0.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	GABPB2	0.12	0.01	enet	16	0.04	1.8e-04	-8.97	5.8	8.6e-09	-0.63	0.01	0.92	FALSE
6	GTEx	Artery Tibial	ARNT	0.09	0.07	lasso	3	0.06	1.5e-05	-5.85	5.7	9.7e-09	-0.82	0.01	0.98	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ECM1	0.04	0.04	blup	26	0.04	4.9e-05	-5.37	5.7	1.2e-08	-0.27	0.02	0.96	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1orf54	0.06	0.02	enet	13	0.02	1.2e-05	5.19	-5.6	2.6e-08	0.26	0.02	0.87	FALSE
16	GTEx	Esophagus Mucosa	ADAMTSL4	0.40	0.40	lasso	5	0.41	5.8e-29	-5.37	5.5	5.2e-08	-0.16	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	SV2A	0.08	0.03	lasso	4	0.04	5.2e-04	4.31	-5.4	5.9e-08	0.21	0.17	0.28	FALSE
4	GTEx	Artery Aorta	RP11-54A4.2	0.12	0.13	lasso	2	0.11	7.7e-07	-5.37	5.4	6.8e-08	-0.15	0.83	0.02	FALSE
5	GTEx	Artery Tibial	ADAMTSL4	0.10	0.06	lasso	4	0.08	6.4e-07	-4.69	5.4	8.5e-08	-0.22	0.87	0.04	FALSE
13	GTEx	Colon Sigmoid	ARNT	0.09	0.00	enet	15	0.03	2.6e-02	1.13	5.3	1.1e-07	-0.40	0.10	0.12	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADAMTSL4	0.07	0.05	blup	33	0.05	5.6e-06	-5.37	5.3	1.3e-07	-0.31	0.36	0.62	FALSE
7	GTEx	Artery Tibial	RP11-54A4.2	0.10	0.07	lasso	4	0.09	1.3e-07	-4.69	5.2	2.2e-07	-0.23	0.85	0.12	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1orf54	0.06	0.03	lasso	1	0.03	1.3e-04	5.19	-5.2	2.2e-07	0.31	0.01	0.73	FALSE
33	GTEx	Skin Sun Exposed Lower leg	SV2A	0.07	0.00	enet	15	0.02	6.0e-03	3.60	-5.2	2.3e-07	0.09	0.05	0.39	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARNT	0.06	0.02	lasso	3	0.02	1.4e-03	-5.85	5.1	2.7e-07	-0.77	0.00	0.99	FALSE