Best TWAS P=3.46e-20 · Best GWAS P=2.91e-49 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | OLFML3 | 0.12 | 0.00 | enet | 23 | 0.00 | 3.0e-01 | -2.0 | 9.2 | 3.5e-20 | -0.39 | 0.04 | 0.49 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PTPN22 | 0.02 | 0.01 | blup | 67 | 0.01 | 9.6e-03 | -8.3 | -8.8 | 1.6e-18 | 0.57 | 0.11 | 0.37 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | PHTF1 | 0.22 | 0.09 | lasso | 5 | 0.19 | 2.2e-14 | -8.8 | 8.5 | 1.3e-17 | -0.47 | 1.00 | 0.00 | TRUE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | DCLRE1B | 0.06 | 0.04 | enet | 11 | 0.04 | 4.3e-05 | -8.3 | 7.8 | 8.2e-15 | -0.58 | 0.04 | 0.92 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PHTF1 | 0.36 | 0.09 | lasso | 8 | 0.12 | 3.5e-13 | 4.3 | 7.5 | 6.0e-14 | -0.35 | 1.00 | 0.00 | TRUE |
| 12 | The Cancer Genome Atlas | Glioblastoma Multiforme | DCLRE1B | 0.20 | -0.01 | blup | 39 | 0.04 | 3.0e-02 | -7.9 | 7.3 | 2.9e-13 | -0.54 | 0.00 | 0.37 | TRUE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PHTF1 | 0.08 | 0.03 | blup | 62 | 0.05 | 2.1e-06 | -7.6 | 7.2 | 6.1e-13 | -0.39 | 0.75 | 0.01 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHTF1 | 0.05 | 0.02 | enet | 7 | 0.03 | 3.1e-07 | -8.8 | 9.2 | 3.5e-20 | -0.48 | 0.22 | 0.63 | FALSE |
| 4 | METSIM | Adipose | PHTF1 | 0.10 | 0.03 | blup | 517 | 0.04 | 1.1e-06 | 4.2 | 8.2 | 3.0e-16 | -0.36 | 0.83 | 0.09 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | AP4B1 | 0.13 | 0.00 | lasso | 4 | 0.01 | 2.0e-01 | 7.1 | 8.0 | 1.6e-15 | -0.47 | 0.10 | 0.19 | FALSE |
| 11 | The Cancer Genome Atlas | Esophageal Carcinoma | DCLRE1B | 0.13 | 0.02 | blup | 39 | 0.08 | 1.8e-03 | 4.7 | 7.0 | 2.9e-12 | -0.46 | 0.01 | 0.36 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | DCLRE1B | 0.08 | 0.04 | enet | 14 | 0.05 | 2.6e-07 | -7.9 | 6.6 | 4.6e-11 | -0.50 | 0.97 | 0.03 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DCLRE1B | 0.02 | 0.00 | blup | 39 | 0.01 | 5.2e-03 | -4.6 | 5.7 | 1.3e-08 | -0.47 | 0.01 | 0.13 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RP4-730K3.3 | 0.08 | 0.01 | blup | 477 | 0.04 | 8.4e-06 | 4.7 | -5.4 | 8.2e-08 | 0.18 | 0.43 | 0.02 | FALSE |
| 7 | YFS | Blood | PTPN22 | 0.17 | 0.02 | bslmm | 497 | 0.10 | 3.8e-30 | -1.2 | -5.3 | 1.3e-07 | 0.25 | 1.00 | 0.00 | FALSE |