Best TWAS P=9.62e-19 · Best GWAS P=6.41e-21 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP11-336K24.12 | 0.17 | 0.02 | lasso | 3 | 0.01 | 1.7e-01 | -5.3 | -6.7 | 2.9e-11 | 0.47 | 0.04 | 0.31 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SMG5 | 0.15 | 0.10 | enet | 10 | 0.10 | 1.2e-07 | 4.5 | -5.6 | 2.6e-08 | 0.23 | 0.98 | 0.00 | TRUE |
| 3 | YFS | Blood | LMNA | 0.05 | 0.04 | enet | 8 | 0.05 | 1.1e-14 | -9.0 | -8.8 | 9.6e-19 | 0.97 | 0.01 | 0.99 | TRUE |
| 4 | YFS | Blood | MSTO1 | 0.13 | 0.08 | blup | 282 | 0.10 | 1.9e-29 | -8.9 | 8.2 | 2.6e-16 | -0.80 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | LMNA | 0.07 | 0.00 | blup | 55 | 0.01 | 9.1e-02 | -4.5 | -7.6 | 2.8e-14 | 0.50 | 0.01 | 0.12 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB25 | 0.03 | 0.00 | enet | 8 | 0.01 | 1.8e-02 | -9.4 | 6.7 | 2.1e-11 | -0.69 | 0.00 | 0.73 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBQLN4 | 0.11 | 0.00 | blup | 33 | 0.04 | 3.8e-05 | -5.0 | 6.7 | 1.8e-11 | -0.63 | 0.01 | 0.88 | FALSE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | UBQLN4 | 0.25 | 0.06 | blup | 33 | 0.14 | 3.6e-04 | -4.4 | 5.8 | 9.0e-09 | -0.31 | 0.01 | 0.35 | FALSE |