Best TWAS P=1.8e-15 · Best GWAS P=1.43e-11 conditioned to 2.44e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AUH | 0.14 | 0.06 | enet | 15 | 0.11 | 1.2e-13 | -5.2 | -5.2 | 2.3e-07 | 0.55 | 0.68 | 0.32 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | IPPK | 0.11 | 0.09 | lasso | 8 | 0.07 | 7.8e-06 | -5.5 | -6.0 | 1.9e-09 | 0.07 | 0.24 | 0.75 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | IPPK | 0.17 | 0.07 | enet | 8 | 0.07 | 2.7e-06 | 6.3 | -6.8 | 1.4e-11 | -0.01 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Uterus | ZNF484 | 0.23 | 0.05 | lasso | 3 | 0.05 | 3.0e-02 | -5.8 | 6.2 | 4.1e-10 | -0.01 | 0.07 | 0.15 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IPPK | 0.06 | 0.03 | blup | 49 | 0.04 | 5.8e-03 | 6.3 | -8.0 | 1.8e-15 | 0.05 | 0.01 | 0.69 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BICD2 | 0.06 | 0.02 | blup | 52 | 0.05 | 2.9e-06 | 5.3 | 6.8 | 8.5e-12 | -0.05 | 0.03 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ECM2 | 0.10 | 0.04 | lasso | 2 | 0.04 | 4.2e-05 | 6.2 | 6.7 | 2.3e-11 | -0.05 | 0.00 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IPPK | 0.03 | 0.02 | blup | 51 | 0.01 | 3.2e-02 | 6.2 | -6.5 | 7.4e-11 | 0.07 | 0.02 | 0.74 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CENPP | 0.19 | 0.09 | blup | 158 | 0.08 | 7.1e-04 | 5.3 | -6.1 | 8.4e-10 | 0.09 | 0.04 | 0.46 | FALSE |