TWAS hub - AUH

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1410	0.0300	7.0e-11	0.064	0.092	0.113	0.096	0.113	3.0e-08	3.0e-11	1.2e-13	9e-12	1.3e-13
2	GTEx	Muscle Skeletal	0.0745	0.0291	5.9e-03	0.007	NA	0.013	NA	0.010	5.6e-02	NA	1.8e-02	NA	3.3e-02
3	TCGA	Brain Lower Grade Glioma	0.0485	0.0213	2.4e-05	0.060	0.051	0.047	NA	0.054	2.2e-07	1.7e-06	3.9e-06	NA	8.5e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Eosinophil Count	10.6	81.6	151.3	-12.3	-0.7	-9.6
Hayfever, allergic rhinitis or eczema	5.4	11.8	18.2	3.9	1.4	4.3
Hypothyroidism/myxoedema (self-reported)	5.4	10.6	13.2	3.6	-2.9	3.2
Smoking status: Current	5.3	8.4	12.4	-3.5	-0.7	-3.5
Ulcerative Colitis	5.0	7.3	12.8	-3.6	-0.1	-3.0
Current tobacco smoking	5.0	8.1	12.3	-3.5	-0.4	-3.5
Waist Hip Ratio (WHR)	4.6	20.6	32.5	5.7	-1.6	5.2
Cholesterol lowering medication	4.6	6.8	10.8	-2.2	-3.3	-2.1
Medication: Levothyroxine sodium	4.4	7.4	10.3	3.2	-2.0	2.8
Irritable Bowel Disease (IBD)	4.2	10.1	19.3	-4.4	-0.2	-3.3
Allergy or Eczema	4.1	10.7	16.3	3.6	1.7	4.0
Medication: Gliclazide	3.9	4.4	6.6	2.5	0.4	2.6
Crohns Disease (2012)	3.7	6.0	9.6	-3.1	-0.9	-2.8
Medication for cholesterol	3.7	5.6	14.4	1.1	3.8	1.0
Ulcerative Colitis (UC)	3.6	6.7	12.6	-3.6	-0.1	-2.8
Other serious medical condition/disability diagnosed by doctor	3.6	4.6	10.6	1.1	-3.2	1.4
Long-standing illness, disability or infirmity	3.4	5.2	14.8	0.0	-3.8	0.8
Prospective memory result	2.9	3.6	5.9	-2.4	-1.2	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	4.9	2.2	-0.6	2.2
Myopia	2.8	4.0	10.2	-0.9	-3.2	-1.0
Family relationship satisfaction	2.7	3.3	6.4	-2.5	0.5	-1.8
Commuting to job workplace: Walk	2.7	2.9	5.0	-1.9	-0.4	-2.2
Wheeze or whistling in the chest in last year	2.5	4.5	6.2	-2.4	-1.3	-2.5
Had major operations	2.5	3.0	4.8	2.2	0.0	2.0
Multivitamins +/- minerals	2.4	3.0	4.7	2.2	-0.3	2.1
Alzheimer’s Disease (in mother)	2.3	2.7	6.2	1.0	-2.5	0.9
Crohns Disease (2017)	2.2	4.9	9.5	-3.1	-0.2	-2.3
Back pain experienced in last month	2.2	3.2	4.3	2.1	-1.1	2.0
Mineral and other dietary supplements	2.2	3.0	4.8	-2.2	1.0	-1.8
Supplements: Fish oil (including cod liver oil)	2.2	2.9	4.7	2.2	-0.6	1.9
Medication: Paracetamol	2.2	3.4	4.9	2.2	0.7	2.2
Alzheimer’s Disease (including proxy)	2.1	3.1	4.2	1.7	-1.5	2.0
Blood White Count	2.0	14.8	26.7	-5.2	-1.2	-4.0
Birth weight	2.0	4.3	6.5	2.5	-1.5	2.1
Sensitivity / hurt feelings	1.9	3.2	5.4	2.0	-0.7	2.3
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	5.9	0.4	2.4	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	3.5	1.9	0.7	1.9
Heart disease (siblings)	1.9	2.3	6.7	-0.3	-2.6	-0.4
Mean Putamen Volume	1.8	2.0	5.0	-0.8	-2.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.3	-1.0	1.8	-1.7
Mouth/teeth dental problems	1.8	2.8	6.1	1.2	2.5	0.9
Medication: Simvastatin	1.8	2.6	7.8	0.2	-2.8	0.2
Mouth/teeth dental problems: Dentures	1.8	3.1	9.3	-0.2	-3.0	-0.1
Medication: Seretide 50 evohaler	1.8	2.1	2.5	-1.2	1.6	-1.5
Commuting to job workplace: Car/motor vehicle	1.8	2.0	2.2	1.5	1.5	1.3
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.3	1.8	0.2	1.8
Handedness (chirality/laterality): Left-handed	1.8	2.1	6.2	0.2	2.5	0.4
Wears glasses or contact lenses	1.8	2.0	6.0	-0.3	-2.4	-0.2
Hypothyroidism (self reported)	1.7	4.0	5.0	2.2	-2.2	1.5
Diabetes (father)	1.7	2.1	2.9	-1.7	-1.4	-1.1
Medication for pain relief, constipation, heartburn	1.7	2.9	5.1	-2.3	-0.0	-1.9
Verbal and Numeric Reasoning (VNR)	1.6	3.9	5.9	2.3	0.9	2.4
Peak expiratory flow (PEF)	1.6	3.6	5.6	2.4	1.0	2.1
Worry too long after embarrassment	1.6	2.7	4.2	2.0	0.3	1.9
Migraine (self-reported)	1.6	2.0	2.7	1.6	1.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	2.8	-1.7	-1.0	-1.4
Supplements: Vitamin C	1.6	1.9	4.7	-0.5	0.9	-2.2
Ever depressed for a whole week	1.6	2.0	5.9	-0.1	2.4	0.4
Breast Cancer	1.5	3.7	5.7	2.4	0.5	2.3
Respiratory disease	1.5	3.4	4.4	-2.1	-1.6	-1.8
Medication for hormone replacement therapy	1.5	1.7	3.0	1.1	-1.7	0.8
Average weekly fortified wine intake	1.5	1.7	1.9	-1.3	-1.3	-1.4
Heart attack	1.5	2.0	4.7	-1.0	-2.2	-0.5
Allergy	1.5	3.5	5.1	-2.1	-1.0	-2.2
Worrier / anxious feelings	1.5	2.8	4.1	1.3	2.0	1.6
Medication: Paracetamol	1.5	2.5	4.0	2.0	0.9	1.7
Knee pain experienced in last month	1.5	2.3	5.9	-0.8	-2.4	-0.6
Alcohol drinker status: Never	1.5	1.8	2.0	-1.4	-1.2	-1.4
Smoking Status	1.4	3.5	6.2	-2.5	0.7	-1.9
Pain all over the body in last month	1.4	1.5	1.8	-1.1	1.3	-1.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.1	0.4	2.0	1.0
Health satisfaction	1.4	1.8	4.7	-2.2	-0.3	-0.8
Number of self-reported non-cancer illnesses	1.4	2.4	7.0	0.3	-2.6	-0.2
Schizophrenia (2018)	1.3	2.7	3.8	-1.2	2.0	-1.6
Illnesses of siblings	1.3	1.8	4.9	0.6	2.2	0.2
Pulse rate	1.3	2.2	3.1	-1.8	1.4	-1.2
Pulse wave Arterial Stiffness index	1.3	1.5	3.2	-1.2	-0.2	-1.8
Eye problems/disorders: None of the above	1.3	1.5	3.2	1.8	0.5	1.0
Illnesses of siblings: Diabetes	1.3	1.6	2.0	1.4	-1.3	1.1
Eye problems/disorders: Cataract	1.3	1.5	2.7	-1.6	-1.0	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	6.1	0.1	2.5	-0.0
Eye problems/disorders: Glaucoma	1.3	1.6	2.2	1.0	1.5	1.2
Fasting Glucose	1.2	1.4	2.4	1.1	1.6	0.9
Schizophrenia (2014)	1.2	2.6	3.1	-1.3	1.8	-1.7
Age when periods started (menarche)	1.2	2.8	4.6	1.7	-2.1	1.0
Had menopause	1.2	1.5	2.8	-0.6	-1.2	-1.7
Financial difficulties in last 2 years	1.2	1.7	3.5	-1.9	0.8	-0.9
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	1.9	1.4	1.3	1.1
Alcohol intake versus 10 years previously	1.2	1.7	2.0	1.4	-1.3	1.3
Glaucoma (self-reported)	1.2	1.5	2.3	1.4	0.5	1.5
Medication: Allopurinol	1.2	1.6	3.4	1.2	-0.2	1.8
Medication: Aspirin	1.2	1.6	3.9	0.4	-2.0	0.9
Miserableness	1.2	2.1	4.1	1.4	-0.4	2.0
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.1	0.6	-2.0	0.4
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.7	-0.9	-1.9	-0.4
Impedance of arm (right)	1.1	4.9	7.8	2.8	2.1	1.7
Medication: Cholesterol lowering	1.1	1.7	4.0	0.6	-2.0	0.8
Angina (self-reported)	1.1	1.5	3.9	-0.7	-2.0	0.2
Suffer from ‘nerves’	1.1	1.7	2.8	1.4	-0.5	1.7
Qualifications: nursing, teaching	1.1	1.7	2.8	-1.4	-0.5	-1.7
Average weekly champagne plus white wine intake	1.1	1.5	1.7	-1.3	1.1	-1.3
Hearing aid user	1.1	1.3	1.9	1.4	0.2	1.4
High cholesterol (Self-reported)	1.1	1.9	4.4	-1.0	-2.1	-0.6
Intelligence (Savage-Jansen 2018)	1.0	3.0	4.7	1.9	0.9	2.2
HDL Cholesterol	1.0	1.6	1.8	-1.3	-1.3	-1.2
LDL Cholesterol	1.0	1.6	4.7	0.4	-2.2	0.2
Average weekly spirits intake	1.0	1.2	2.0	-1.4	-0.8	-1.0
Vitamin and mineral supplements	1.0	1.4	3.5	-1.9	-0.1	-0.9
Hip circumference	1.0	4.4	8.7	-2.9	-0.9	-1.9
Illnesses of mother	1.0	1.3	1.7	-1.2	0.9	-1.3
Impedance of arm (left)	1.0	4.7	9.0	3.0	1.5	1.7
Pulse wave peak to peak time	1.0	1.2	2.7	1.0	0.2	1.6
Mean time to correctly identify matches	1.0	2.0	5.0	0.6	-2.2	0.8
Chest pain or discomfort	1.0	1.4	2.0	-1.4	-0.6	-1.4
Asthma (self-reported)	1.0	1.9	4.0	-2.0	-0.7	-1.1
Alcohol drinker status: Previous	1.0	1.2	2.0	-1.3	0.0	-1.4
Depression (Nagel 2018)	0.9	1.4	3.4	0.1	1.8	-0.9
Cardiovascular Disease	0.9	3.1	5.6	-1.8	-2.4	-0.8
Number of treatments/medications taken	0.9	1.7	2.9	1.3	-0.7	1.7
Qualifications: CSEs or equivalent	0.9	1.2	2.6	-1.6	0.6	-0.8
Stomach or abdominal pain in last month	0.9	1.2	2.1	0.6	1.5	1.0
Alcohol usually taken with meals	0.9	1.5	4.2	-0.6	0.3	-2.0
Noisy workplace	0.9	1.2	1.5	1.2	1.2	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.0	1.0	0.1	1.4
Birth weight of first child	0.9	1.6	2.7	1.5	-0.1	1.6
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.8	1.3	-0.1	1.7
Medication: Ibuprofen	0.9	1.1	1.6	1.1	0.6	1.3
Smoking status: Previous	0.9	1.4	2.7	1.2	0.1	1.6
Medication: Aspirin	0.9	1.1	2.9	0.2	-1.7	0.7
Medication: Atorvastatin	0.9	1.2	3.4	-0.1	-1.8	0.2
Diastolic blood pressure, automated reading	0.9	2.7	4.6	-2.1	0.3	-1.8
Triglycerides	0.8	1.2	2.6	1.6	-0.2	1.1
Blood Red Count	0.8	8.0	23.8	-0.2	-4.9	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	1.4	-0.1	1.0
Angina	0.8	1.1	2.9	-0.5	-1.7	0.3
Supplements: Zinc	0.8	0.9	1.3	0.7	1.0	1.1
Pack years adult smoking proportion	0.8	1.2	2.8	-0.8	1.7	-0.6
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.6	1.3	0.8	0.7
Number of incorrect matches in round	0.8	1.4	1.9	-0.9	-1.2	-1.4
Time employed in main current job	0.8	0.9	1.7	0.2	1.3	-1.0
Depression (self-reported)	0.8	1.0	1.1	1.0	0.9	1.0
Length of working week for main job	0.8	0.8	2.3	0.1	1.5	-0.5
Breastfed as a baby	0.8	1.0	2.9	0.0	-1.7	0.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.5	-0.5	1.6	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.6	0.9	1.3	0.6
Illnesses of father: High blood pressure	0.8	1.0	2.0	-0.9	-0.2	-1.4
Number of operations (self-reported)	0.8	1.1	2.8	0.4	-1.7	0.6
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.5	-0.8	-1.2	-0.9
Fractured/broken bones in last 5 years	0.8	1.0	1.4	-1.2	-0.6	-1.1
Commuting to job workplace: Cycle	0.8	1.0	1.6	-1.2	-0.0	-1.2
Neuroticism (Nagel 2018)	0.7	1.6	2.6	1.5	0.4	1.6
Worry (Nagel 2018)	0.7	1.5	3.5	0.6	1.9	0.8
Alzheimer’s Disease (in father)	0.7	0.8	2.1	0.5	-0.1	1.4
BMI	0.7	4.3	8.1	-2.8	-1.5	-1.6
Hand grip strength (left)	0.7	1.9	4.0	0.7	2.0	1.1
Diabetes (mother)	0.7	0.9	1.6	1.3	-0.9	0.5
Hand grip strength (right)	0.7	1.8	2.4	1.1	1.5	1.4
Serious illness, injury or assault to yourself	0.7	0.8	1.1	-0.8	-1.1	-0.8
Hair/balding pattern: Pattern 2	0.7	0.9	1.5	1.2	-0.8	0.7
Father’s age at death	0.7	1.0	1.3	-1.1	0.7	-1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	3.7	1.1	1.9	1.3
Happiness	0.7	0.8	2.2	-1.5	-0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.3	-0.0	1.8	-0.3
Gout (self-reported)	0.7	1.0	1.6	0.8	-0.9	1.3
Number of full brothers	0.7	0.9	2.3	0.5	-1.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.1	-1.1	-0.6	-1.0
Leg pain on walking	0.7	0.8	1.5	-0.9	-1.2	-0.5
Osteoporosis (self-reported)	0.7	0.9	2.5	0.5	1.6	0.1
Guilty feelings	0.7	1.1	2.1	0.9	-0.5	1.5
Mother’s age at death	0.7	0.9	2.0	0.8	1.4	0.1
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.3	0.9	2.1	0.5
Reaction Time	0.6	1.2	2.5	0.3	-1.6	1.0
Neuroticism	0.6	1.4	1.9	1.1	1.4	1.1
Hearing difficulty/problems: Yes	0.6	0.9	2.0	-0.8	-1.4	-0.1
Systolic blood pressure, automated reading	0.6	1.8	2.0	-1.4	-1.4	-1.2
Taking other prescription medications	0.6	0.9	1.2	0.9	-0.7	1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	0.5	0.4	1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	-0.5	1.0	-0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	0.4	1.1	0.8
Nervous feelings	0.6	1.1	3.1	-0.4	1.8	-0.0
Neuroticism score	0.6	1.3	2.8	0.9	0.4	1.7
Falls in the last year	0.6	0.8	1.9	1.4	-0.4	0.5
Asthma	0.6	1.2	2.8	-1.7	-0.7	-0.6
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.2	-0.8	1.1	-0.6
Shortness of breath walking on level ground	0.6	0.8	1.7	-0.7	1.3	-0.2
Pulse rate, automated reading	0.6	2.1	3.0	-1.7	0.5	-1.7
Alcohol intake frequency.	0.6	1.5	2.6	-1.6	-0.8	-1.1
Commuting to job workplace: Public transport	0.6	0.8	1.0	-0.9	-1.0	-0.7
Medication: Blood pressure	0.6	1.1	1.9	-0.7	-1.4	-1.0
Average weekly beer plus cider intake	0.6	0.9	1.3	1.0	0.6	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	0.9	1.0	0.5	1.0
Schizophrenia vs Biploar Disorder	0.5	0.6	1.8	0.1	1.3	-0.4
Rheumatoid Arthritis	0.5	0.6	1.4	0.4	-1.2	0.5
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.4	1.2	-0.7	1.1
Chronotype (morning person)	0.5	1.2	2.1	1.4	0.3	1.2
Townsend deprivation index at recruitment	0.5	0.8	1.2	-1.1	-0.7	-0.7
Sitting height	0.5	3.3	5.2	-2.3	1.6	-1.4
High blood pressure (mother)	0.5	0.7	1.3	0.4	-1.1	0.9
Waist circumference	0.5	1.9	5.5	-0.4	-2.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.5	-1.2	0.8	-0.4
Had other major operations	0.5	0.6	0.7	-0.7	0.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.6	-1.3	0.7	-0.2
Number of live births	0.5	0.8	1.1	-1.1	-0.4	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.6	0.6	1.6	0.6
Lung cancer (father)	0.5	0.6	1.0	-1.0	0.5	-0.8
Exposure to tobacco smoke at home	0.5	0.6	0.9	-0.7	1.0	-0.5
Tense / ‘highly strung’	0.5	0.8	2.1	-1.4	-0.0	-0.6
Number of children fathered	0.5	0.6	1.1	0.8	0.4	1.0
Emphysema/chronic bronchitis	0.5	0.6	1.4	-0.4	1.2	-0.4
Medication: Omeprazole	0.5	0.7	1.8	-0.4	1.3	0.1
Hypertension (Self-reported)	0.5	1.3	2.2	-1.0	-1.5	-0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	0.6	-0.8	0.9
Irritability	0.5	0.9	2.2	0.5	-0.5	1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.8	-0.9	0.8	-0.5
Pack years of smoking	0.5	0.8	2.0	-0.5	1.4	-0.4
Impedance of whole body	0.5	2.7	5.7	2.4	1.1	1.2
Bipolar Disorder or Schizophrenia	0.4	1.0	1.4	-0.9	0.9	-1.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.2	1.1	0.6	1.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.9	-0.1	1.0	-0.8
Relative age of first facial hair	0.4	0.8	1.8	-0.5	1.4	-0.5
Impedance of leg (right)	0.4	2.1	4.1	2.0	0.6	1.4
High blood pressure	0.4	1.0	1.8	-0.9	-1.3	-0.7
Supplements: Glucosamine	0.4	0.5	1.3	0.2	-1.1	-0.4
Body mass index (BMI)	0.4	1.7	2.4	-1.5	-1.5	-0.5
Diabetes (self-reported)	0.4	0.5	1.5	0.1	-1.2	0.3
Medication: Lansoprazole	0.4	0.4	1.3	-1.1	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	1.7	1.0	1.3	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.5	0.3	0.2	1.2
Pulse wave reflection index	0.4	0.5	1.0	1.0	-0.8	-0.1
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.9	0.9	0.1
Headache pain in last month	0.4	0.7	1.3	0.7	-1.1	0.6
Age at first live birth	0.4	0.7	1.9	0.0	1.4	0.2
Neck or shoulder pain in last month	0.4	0.6	0.9	1.0	-0.4	0.9
Heart disease (mother)	0.4	0.5	0.9	0.7	-0.9	-0.2
Arm predicted mass (right)	0.4	1.9	3.2	-1.8	-1.3	-0.7
Breast cancer (self-reported)	0.4	0.4	0.7	0.8	0.5	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.1	1.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.4	0.7	1.2	1.0
Leg fat percentage (left)	0.4	1.3	2.3	-1.2	-1.5	-0.5
Age started oral contraceptive pill	0.4	0.5	1.2	1.1	-0.6	0.1
Age at First Birth	0.3	0.4	0.8	0.4	-0.5	0.9
Body Mass Index (BMI) (2010)	0.3	0.5	0.8	-0.7	0.5	-0.9
Lupus	0.3	0.5	1.4	-0.2	-1.2	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	-0.6	-0.0	-0.9
Blood Platelet Count	0.3	3.0	5.1	2.2	1.2	1.6
Systolic Blood Pressure	0.3	1.5	4.1	-0.7	-2.0	-0.2
Medication: Metformin	0.3	0.5	1.2	-0.3	-1.1	-0.3
Severe depression (siblings)	0.3	0.3	0.7	-0.5	0.8	0.1
Relative age voice broke	0.3	0.4	0.8	-0.6	0.9	-0.5
Medication: Atenolol	0.3	0.3	0.8	-0.3	-0.5	0.9
Hearing difficulty/problems with background noise	0.3	0.4	1.2	-1.1	0.1	-0.3
Medication: Ramipril	0.3	0.4	0.6	-0.7	-0.8	0.0
Arm fat mass (right)	0.3	1.2	2.6	-1.0	-1.6	-0.2
Leg fat percentage (right)	0.3	0.9	1.9	-0.9	-1.4	-0.1
Arm fat-free mass (right)	0.3	1.8	3.1	-1.8	-1.3	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	-0.4	-0.3	-0.9
Medication: Blood pressure	0.3	0.5	1.2	-0.2	-1.1	0.5
Whole body fat mass	0.3	1.1	2.5	-0.8	-1.6	-0.2
Leg fat mass (right)	0.3	1.0	2.2	-0.9	-1.5	-0.1
Comparative height size at age 10	0.3	1.6	2.3	-1.5	-0.1	-1.5
Overall health rating	0.3	0.7	2.1	-0.2	-1.5	0.1
Age at last live birth	0.3	0.5	1.4	0.3	1.2	0.1
Arm fat percentage (left)	0.3	1.1	3.0	-0.5	-1.7	0.0
Average weekly red wine intake	0.3	0.4	1.0	-0.5	0.0	-1.0
Mood swings	0.3	0.6	1.3	0.5	-0.4	1.1
Osteoarthritis (self-reported)	0.3	0.4	0.9	-0.4	-1.0	-0.1
Arm fat mass (left)	0.3	1.2	2.8	-1.0	-1.7	-0.2
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.5	-0.4	0.8
Medication: Bendroflumethiazide	0.3	0.4	0.7	-0.8	-0.4	-0.6
Ever smoked	0.3	0.5	0.6	-0.6	0.6	-0.8
Risk taking	0.3	0.5	0.9	-1.0	0.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.5	0.9	-0.2
Leg fat mass (left)	0.3	1.4	2.9	-1.1	-1.7	-0.2
Arm predicted mass (left)	0.3	1.4	2.7	-1.6	-1.0	-0.6
Bipolar Disorder (2018)	0.2	0.3	1.0	0.1	-1.0	0.2
Ovarian Cancer	0.2	0.3	0.7	-0.4	0.8	-0.2
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.7	-0.2	-0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.8	-0.0	-0.3	0.9
Lung FVC	0.2	0.9	2.3	0.6	1.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-0.2	0.4	1.0
Impedance of leg (left)	0.2	0.9	2.2	1.5	0.1	0.6
Trunk fat mass	0.2	0.7	1.7	-0.6	-1.3	-0.2
Forced vital capacity (FVC)	0.2	0.9	2.0	0.2	1.4	0.8
Fluid intelligence score	0.2	0.5	0.9	0.9	-0.2	0.7
Weight	0.2	1.2	2.1	-1.4	-1.1	-0.4
Arm fat percentage (right)	0.2	0.8	2.1	-0.4	-1.4	0.0
Trunk fat-free mass	0.2	1.1	2.4	-1.6	-1.0	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	-0.3	0.1	-0.9
Trunk predicted mass	0.2	1.1	2.3	-1.5	-1.0	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	0.4	-1.0	-0.2
Loud music exposure frequency	0.2	0.2	0.6	0.0	0.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	-0.3	-0.9	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	1.1	0.5	1.1	1.0
Body fat percentage	0.2	0.7	2.0	-0.3	-1.4	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.1	0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.0	-0.4	0.7
Number of full sisters	0.2	0.3	0.6	-0.4	0.8	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.0	-0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.4	1.0	-0.0
Whole body fat-free mass	0.2	1.1	2.4	-1.6	-0.9	-0.3
Loneliness, isolation	0.2	0.3	0.8	-0.9	-0.4	-0.3
Ever had bowel cancer screening	0.2	0.2	0.3	-0.1	-0.5	-0.6
Friendships satisfaction	0.2	0.2	0.6	-0.7	-0.0	-0.0
Whole body water mass	0.2	1.0	2.3	-1.5	-0.8	-0.2
Basal metabolic rate	0.2	0.9	2.0	-1.4	-0.8	-0.2
Arm fat-free mass (left)	0.2	1.0	2.2	-1.5	-0.9	-0.3
Unable to work because of sickness or disability	0.2	0.3	0.8	-0.9	-0.2	-0.2
Pain experienced in last month	0.2	0.3	0.4	-0.6	0.6	-0.3
Major Depression (MDD)	0.1	0.1	0.2	-0.4	-0.2	0.4
Neuroticism (2016)	0.1	0.2	0.3	0.5	0.2	0.5
Height	0.1	1.3	1.9	0.6	-1.4	1.3
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.0	-0.6	-0.7
Tanning	0.1	0.8	1.2	-0.8	-1.1	-0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.4	-0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	0.2	-0.6	0.2
Medication: Co-codamol	0.1	0.2	0.3	0.5	-0.4	0.2
Leg fat-free mass (left)	0.1	0.3	0.7	-0.8	-0.1	0.4
Trunk fat percentage	0.1	0.5	1.5	-0.1	-1.2	-0.1
Maternal smoking around birth	0.1	0.2	0.5	0.2	0.0	0.7
Past tobacco smoking	0.1	0.1	0.3	-0.2	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.0	0.3	0.6
Qualifications: None of the above	0.1	0.2	0.3	0.2	-0.5	0.5
Medication: Amlodipine	0.1	0.1	0.2	-0.4	-0.3	0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.2	-0.1	0.5
Comparative body size at age 10	0.1	0.4	0.6	0.6	0.8	0.4
Qualifications: College or University degree	0.1	0.2	0.5	-0.2	0.7	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.1	-0.4	0.4	-0.0
Leg fat-free mass (right)	0.1	0.4	1.2	-1.1	-0.2	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.1	-0.8	0.3
Leg predicted mass (right)	0.1	0.4	1.3	-1.1	-0.2	-0.1
Financial situation satisfaction	0.1	0.2	0.3	-0.5	0.6	0.1
Medication: Lisinopril	0.1	0.1	0.2	0.4	0.1	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	-0.1	-0.1	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.2	-0.4	-0.1
Heel T-Score	0.0	0.2	0.3	-0.5	0.5	-0.1
Hair Pigment	0.0	0.5	1.6	-0.0	-1.2	-0.0
Fed-up feelings	0.0	0.1	0.2	0.2	-0.0	0.4
Leg predicted mass (left)	0.0	0.3	0.6	-0.8	-0.1	0.4
Standing height	0.0	0.3	0.4	0.6	0.6	0.5
High blood pressure (siblings)	0.0	0.1	0.1	-0.4	0.0	-0.2
Supplements: Calcium	0.0	0.0	0.0	0.2	0.2	0.1

Hub : Genes

AUH

Models

Trait associations