TWAS hub - AK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.139	0.0520	0.00060	0.114	NA	0.138	NA	0.111	5.2e-08	NA	1.7e-09	NA	7.1e-08
2	METSIM	Adipose	0.055	0.0217	0.00056	0.063	0.018	0.040	0.039	0.050	9.8e-10	8.6e-04	1.0e-06	1.4e-06	5.6e-08
3	YFS	Blood	0.430	0.0424	0.00000	0.219	0.186	0.229	0.217	0.224	4.1e-70	1.6e-58	1.3e-73	2.1e-69	8.4e-72
4	TCGA	Colon Adenocarcinoma	0.103	0.0420	0.00120	0.034	0.031	0.035	NA	0.028	4.7e-03	6.6e-03	4.2e-03	NA	9.8e-03
5	TCGA	Pancreatic Adenocarcinoma	0.167	0.0700	0.00360	0.014	0.014	0.052	NA	0.020	8.5e-02	8.1e-02	3.3e-03	NA	5.0e-02
6	TCGA	Stomach Adenocarcinoma	0.071	0.0270	0.00017	0.030	0.054	0.054	NA	0.054	2.7e-03	8.3e-05	9.1e-05	NA	9.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Risk taking	4.1	6.0	8.5	-2.9	-2.5	-2.2	-2.8	-2.2	-2.0
Fed-up feelings	3.9	7.1	12.8	2.4	2.3	2.1	2.7	3.6	2.6
Blood White Count	3.5	26.1	41.1	-4.7	-4.2	-3.6	-6.4	-6.2	-4.9
Mood swings	3.4	6.2	11.7	1.4	2.6	2.4	2.9	3.4	1.5
Mean Putamen Volume	2.9	3.4	6.1	-2.5	-1.4	-1.1	-2.4	-1.4	-1.7
Ever had prostate specific antigen (PSA) test	2.7	3.1	7.0	-0.3	2.6	2.3	2.0	1.4	-0.0
Depressed Affect (Nagel 2018)	2.5	5.2	9.2	1.5	2.6	2.6	2.3	3.0	1.2
Primary Biliary Cirrhosis	2.5	3.6	6.2	0.8	2.5	2.2	2.2	2.1	0.4
Unable to work because of sickness or disability	2.3	3.0	4.5	-1.7	-1.4	-1.3	-2.1	-2.1	-1.6
Fasting Glucose	2.1	2.5	3.9	-0.9	-1.7	-2.0	-1.6	-1.9	-1.1
Medication: Metformin	2.1	2.9	5.1	-2.3	2.0	1.3	1.3	1.2	-2.0
Supplements: Vitamin C	2.1	2.5	8.8	-3.0	0.4	1.3	-0.7	0.7	-1.8
Irritability	2.1	3.5	6.7	1.3	2.2	2.6	1.7	2.0	1.2
Pain experienced in last month	2.1	3.6	7.6	2.8	-2.0	-2.1	-0.7	-0.8	2.0
Number of children fathered	2.0	2.2	5.0	-2.2	-0.2	0.3	-1.4	-1.1	-2.2
Blood Red Count	1.9	18.1	35.8	-6.0	0.9	2.7	-5.2	-2.0	-5.8
Neck or shoulder pain in last month	1.9	2.6	4.8	-2.1	1.7	1.9	-0.2	-0.1	-2.2
Mean time to correctly identify matches	1.9	3.6	10.5	-3.2	0.1	0.2	-0.8	-1.2	-3.0
Tinnitus: Yes, now most or all of the time	1.9	2.2	5.7	2.4	0.3	0.3	1.1	0.8	2.4
Rheumatoid Arthritis	1.8	2.5	3.7	-0.6	-1.9	-1.7	-1.9	-1.8	-1.0
Heart disease (mother)	1.8	2.2	8.4	1.5	-0.7	-0.6	0.2	1.4	2.9
Commuting to job workplace: Cycle	1.8	2.2	4.7	-1.6	-1.4	-1.0	-2.2	-1.6	-0.8
Alcohol drinker status: Previous	1.8	2.1	4.2	0.5	1.7	2.1	1.4	1.8	-0.2
Schizophrenia (2018)	1.7	3.5	11.5	-3.4	-2.4	-2.0	0.0	0.0	0.0
Maternal smoking around birth	1.7	2.5	7.0	-2.6	0.9	1.8	-1.1	-0.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	5.2	1.6	2.0	1.5	2.2	2.3	1.5
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.8	-0.4	2.1	2.2	1.2	1.5	-0.2
Schizophrenia (2014)	1.5	3.4	9.3	-3.0	-2.3	-2.3	0.0	0.0	0.0
Time employed in main current job	1.5	1.7	5.2	2.3	-1.1	-0.9	0.1	0.4	1.7
Medication: Gliclazide	1.5	1.7	3.2	-1.0	1.6	1.5	0.6	1.8	-1.0
Mother’s age at death	1.5	1.9	3.5	1.9	-1.1	-1.8	0.6	0.2	1.8
Schizophrenia vs Biploar Disorder	1.4	1.9	4.6	-2.1	-2.1	-1.5	0.0	0.0	0.0
Reaction Time	1.4	2.7	8.7	-3.0	-0.1	-0.0	-0.9	-1.0	-2.5
Breast Cancer	1.4	3.3	4.1	1.8	2.0	1.1	1.9	2.0	1.8
Systolic Blood Pressure	1.4	7.0	14.1	-2.4	-1.9	-1.8	-3.8	-3.1	-2.3
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.1	1.6	0.4	0.8	0.8	2.0	1.6
Systolic blood pressure, automated reading	1.4	4.0	7.2	-1.3	-1.9	-2.6	-2.0	-2.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.4	-0.8	1.8	1.8	1.5	1.3	-0.6
Diabetes (self-reported)	1.4	2.2	3.9	-1.3	2.0	1.8	0.7	1.9	-0.3
Pulse wave Arterial Stiffness index	1.4	1.6	3.8	1.9	-0.8	-1.5	0.7	0.0	1.6
Pulse wave peak to peak time	1.4	1.7	3.8	-1.9	1.0	1.6	-0.6	-0.0	-1.5
Overall health rating	1.4	3.1	6.5	-1.3	2.4	2.5	0.9	1.3	-1.5
Age started oral contraceptive pill	1.4	1.8	4.5	1.6	0.2	-0.1	2.1	0.9	1.6
Miserableness	1.3	2.3	4.9	0.8	1.7	1.8	1.4	2.2	0.5
Depression (Nagel 2018)	1.2	1.8	4.0	-0.3	2.0	1.8	1.0	1.2	-0.7
Smoking Status	1.2	2.9	6.1	-1.9	-1.0	-0.6	-2.5	-1.8	-1.8
Medication: Co-codamol	1.2	1.4	2.8	-0.8	1.4	1.7	0.3	0.5	-1.7
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	6.2	2.5	-0.8	-0.7	-0.0	0.4	2.0
Medication: Amlodipine	1.2	1.6	3.9	-1.8	0.4	0.6	-1.0	-1.1	-2.0
Medication: Blood pressure	1.2	2.1	6.2	-2.4	0.4	0.4	-0.5	-0.5	-2.5
Ever had bowel cancer screening	1.2	1.4	2.7	-1.6	-1.0	-0.8	-0.8	-1.6	-0.9
Breast cancer (self-reported)	1.2	1.5	3.0	1.3	0.7	0.3	1.4	1.3	1.7
Average weekly champagne plus white wine intake	1.2	1.7	3.3	0.6	1.6	1.2	1.8	1.3	0.8
Medication: Levothyroxine sodium	1.1	1.8	3.5	-1.1	-1.9	-1.6	-1.6	-1.1	0.0
Hair/balding pattern: Pattern 2	1.1	1.4	3.1	0.4	1.3	1.6	0.9	1.8	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.0	-0.9	2.0	1.9	1.6	1.9	0.2
Mouth/teeth dental problems: Dentures	1.1	1.9	4.1	-0.0	-1.6	-1.2	-2.0	-1.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.9	-0.3	1.8	2.2	0.8	1.2	-0.2
Headache pain in last month	1.1	1.8	3.2	-1.6	1.4	1.8	0.3	-0.0	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	5.8	2.4	0.2	-0.2	1.3	1.2	2.3
Neuroticism (Nagel 2018)	1.0	2.4	5.1	0.8	1.6	1.5	1.9	2.3	0.7
Body Mass Index (BMI) (2010)	1.0	1.3	2.4	-0.7	1.6	1.5	1.1	1.2	-0.4
Heel T-Score	1.0	7.6	13.5	-1.6	3.2	3.4	2.8	3.7	0.1
Angina (self-reported)	1.0	1.3	3.4	-1.7	-0.4	0.1	-1.8	-0.8	-0.6
Diabetes diagnosed by doctor	1.0	1.6	5.2	-2.3	1.1	0.9	-0.5	0.7	-1.4
Pack years of smoking	1.0	1.5	3.5	-1.6	-0.2	-0.2	-1.3	-1.0	-1.9
Cardiovascular Disease	0.9	3.1	7.6	-2.8	-0.1	-0.6	-1.7	-1.0	-2.6
Diabetes (father)	0.9	1.1	2.1	0.9	0.8	1.1	0.4	1.4	1.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.5	0.9	0.8	1.2	1.2	1.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.0	-1.4	1.2	0.2	0.6	-0.7	-1.4
Waist circumference	0.9	3.5	5.6	-2.0	2.4	2.2	0.8	1.3	-1.9
Past tobacco smoking	0.9	1.6	3.6	1.5	0.3	-0.3	1.9	1.2	1.5
Allergy	0.9	2.0	3.2	1.8	1.6	0.9	1.5	1.5	0.9
Fluid intelligence score	0.9	1.9	5.2	2.2	-0.1	-0.0	0.9	0.7	2.3
Falls in the last year	0.9	1.2	3.0	-0.1	-1.4	-1.7	-1.3	-0.4	0.7
Noisy workplace	0.9	1.1	1.9	-1.0	-1.0	-0.4	-1.3	-1.0	-1.4
Breastfed as a baby	0.9	1.1	3.1	0.9	-1.1	-1.8	0.7	0.2	1.0
Birth weight of first child	0.9	1.6	4.2	-1.8	0.1	-0.1	-0.6	-1.1	-2.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.4	-0.2	1.6	1.8	0.3	0.3	-0.1
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.3	0.2	1.2	1.0	1.5	1.1	0.1
Qualifications: nursing, teaching	0.9	1.5	3.3	1.7	-0.3	-0.9	1.2	0.7	1.8
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.7	-1.3	0.8	1.3	-0.9	-0.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.1	-0.1	1.4	1.4	1.1	1.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.7	-1.6	-0.5	-0.5	-1.4	-1.1	-0.9
Crohns Disease (2012)	0.8	1.3	2.9	1.2	-1.1	-1.4	-0.2	-0.1	1.7
Blood Eosinophil Count	0.8	6.3	13.8	-0.4	3.7	3.7	1.9	2.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.8	0.8	0.7	0.6	1.3	1.3	1.2
Pack years adult smoking proportion	0.8	1.2	3.5	-1.5	0.2	0.1	-0.8	-0.7	-1.9
Medication: Atenolol	0.8	0.9	2.1	-1.5	0.9	0.8	0.4	0.1	-1.4
Illnesses of siblings	0.8	1.2	3.6	1.9	-0.3	-0.4	0.6	0.5	1.6
Neuroticism score	0.8	1.6	2.9	0.6	1.5	1.7	1.3	1.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.9	-0.1	1.4	1.0	1.3	1.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.5	-0.7	1.3	1.6	0.5	0.9	-0.3
Depression (self-reported)	0.8	1.0	2.8	0.1	1.5	1.7	0.2	0.8	-0.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.8	0.2	1.5	1.7	0.6	0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	0.1	1.3	1.2	1.5	1.1	0.0
Shortness of breath walking on level ground	0.8	0.9	1.9	-1.3	0.8	1.4	-0.2	0.7	-0.8
Medication: Seretide 50 evohaler	0.8	0.9	2.0	0.6	-1.4	-1.4	-0.3	-1.0	0.4
Leg pain on walking	0.8	0.9	2.2	-0.1	-1.2	-1.5	-1.0	-0.8	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.1	-1.4	0.3	0.2	-0.6	-0.5	-1.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.2	0.3	-1.4	-1.5	-0.3	-1.1	0.7
Medication: Aspirin	0.8	1.0	2.6	-1.6	-0.2	-0.3	-1.3	-0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.0	-0.4	1.1	1.7	0.8	0.9	-0.4
Hearing aid user	0.8	0.9	1.8	0.5	0.9	0.6	0.7	1.4	1.3
Illnesses of father: High blood pressure	0.8	1.0	1.7	0.7	1.1	1.3	0.7	1.3	0.7
Ever smoked	0.8	1.3	2.8	-1.2	-0.3	0.3	-1.6	-1.0	-1.7
Age at First Birth	0.7	1.0	3.0	1.4	-0.3	-0.2	0.6	0.9	1.7
HbA1C	0.7	0.8	2.1	-1.4	-0.3	-0.5	-0.7	-0.9	-0.9
Lupus	0.7	1.1	2.7	1.5	-0.6	-0.6	-0.2	0.8	1.6
Blood Platelet Count	0.7	8.3	22.2	1.5	-3.6	-4.7	-2.1	-2.6	0.6
Waist Hip Ratio (WHR)	0.7	3.1	6.5	1.1	2.6	2.1	2.3	1.0	0.5
Allergy or Eczema	0.7	1.9	4.3	-0.1	-2.1	-1.5	-1.6	-0.7	1.4
Hypothyroidism (self reported)	0.7	1.5	4.2	-1.8	-0.9	-0.3	-2.0	-0.5	-0.8
Chronotype (morning person)	0.7	1.7	3.8	1.1	-1.2	-1.6	0.6	0.9	1.9
Angina	0.7	0.9	2.7	-1.5	-0.4	0.0	-1.6	-0.7	-0.4
Average weekly fortified wine intake	0.7	0.8	2.0	-0.1	1.0	0.3	1.4	1.3	-0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	0.0	1.4	1.0	1.2	0.5	0.2
Pain all over the body in last month	0.7	0.8	2.3	1.5	-0.6	-0.9	-0.2	-0.1	1.1
Worrier / anxious feelings	0.7	1.2	2.5	0.5	1.6	1.3	1.5	0.9	0.3
Prospective memory result	0.7	0.8	1.7	0.7	1.3	1.2	0.9	0.6	0.6
Lung cancer (father)	0.7	0.8	2.0	-1.4	-0.5	-0.3	-0.3	-0.9	-1.2
Illnesses of mother	0.7	0.9	4.1	-1.0	-0.1	0.1	-0.2	-0.3	-2.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	3.5	-1.9	-1.2	-0.5	-1.7	-0.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	0.7	1.3	1.5	1.0	0.4	0.3
Qualifications: College or University degree	0.7	2.2	5.4	1.8	-0.7	-0.5	1.2	1.5	2.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.3	-0.3	-0.8	-1.1	-1.1	-0.6	-1.1
Medication: Blood pressure	0.7	1.4	2.9	-1.7	-0.3	-0.9	-1.1	-0.8	-1.7
Leg fat percentage (left)	0.7	2.4	3.9	-1.8	1.8	1.9	0.2	0.9	-2.0
Bipolar Disorder or Schizophrenia	0.6	1.4	6.9	-2.6	-0.7	-0.9	0.0	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	6.3	1.7	-1.3	-0.5	-0.7	0.1	2.5
Crohns Disease (2017)	0.6	1.3	3.7	1.9	-0.8	-0.7	0.2	0.0	1.6
HDL Cholesterol	0.6	1.0	3.2	0.1	-1.4	-1.8	-0.5	-0.8	0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.4	-1.8	0.0	0.7	0.0	0.0	0.0
Supplements: Zinc	0.6	0.7	1.1	-0.7	0.9	1.0	0.6	0.5	-1.0
Trunk fat percentage	0.6	2.3	3.5	-1.5	1.9	1.8	0.2	1.2	-1.9
High blood pressure	0.6	1.7	4.3	-2.1	0.1	-0.4	-1.1	-0.6	-2.1
Trunk fat mass	0.6	2.6	3.7	-1.8	1.9	1.7	0.5	1.3	-1.9
Number of incorrect matches in round	0.6	1.0	1.9	-1.4	1.0	1.1	0.9	0.7	-0.8
Alcohol usually taken with meals	0.6	1.0	2.5	0.9	-1.0	-1.6	-0.2	-1.0	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.5	1.2	0.2	0.8	0.4	1.1	1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	0.4	1.3	1.3	0.5	0.5	0.0
Mouth/teeth dental problems	0.6	0.9	2.7	0.5	1.1	0.5	1.6	0.9	0.6
Heart attack	0.6	0.8	1.8	-1.3	-0.5	-0.5	-1.2	-0.8	-0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	0.1	-1.2	-1.0	-1.0	-0.1	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.1	2.0	0.2	1.4	1.2	0.9	1.4	0.2
Peak expiratory flow (PEF)	0.6	1.4	2.6	0.3	-1.6	-1.6	-1.5	-0.8	0.3
Blood clot in the leg (DVT)	0.6	0.7	0.9	-0.9	-0.7	-0.7	-0.9	-0.9	-1.0
High blood pressure (siblings)	0.6	0.8	2.2	-1.5	-0.5	-0.1	-1.3	-0.5	-0.7
Body fat percentage	0.6	2.3	3.6	-1.6	1.8	1.8	0.2	1.0	-1.9
Leg fat percentage (right)	0.6	2.3	3.6	-1.7	1.9	1.8	0.2	0.7	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.7	-1.6	-0.6	-0.3	-0.6	-0.7	-0.7
Leg fat mass (right)	0.6	2.4	3.6	-1.8	1.9	1.8	0.5	1.3	-1.5
Hypertension (Self-reported)	0.6	1.7	4.8	-2.1	0.5	0.1	-0.9	-0.4	-2.2
Illnesses of siblings: Diabetes	0.6	0.7	1.5	-1.2	0.9	0.6	1.0	0.7	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.1	1.4	-0.4	-0.2	0.9	1.0	1.4
Back pain experienced in last month	0.6	0.9	3.5	-1.9	-0.2	-0.1	0.0	-0.2	-1.3
Medication: Aspirin	0.6	0.8	2.0	-1.4	-0.1	-0.3	-1.1	-0.7	-1.0
Diastolic blood pressure, automated reading	0.6	1.7	3.5	-0.8	-0.3	-0.4	-1.8	-1.9	-1.6
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.3	1.8	0.2	0.7	1.5	0.8	1.6
Cholesterol lowering medication	0.6	0.9	2.6	-1.6	-0.5	-0.7	-1.1	-0.3	-0.6
Leg fat mass (left)	0.6	2.3	3.3	-1.8	1.7	1.7	0.4	1.3	-1.6
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	-0.8	-0.2	-0.3	-0.8	-1.2	-0.8
Alzheimer’s Disease (in father)	0.5	0.6	1.4	-0.2	-1.2	-1.1	-0.5	-0.7	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.9	1.3	0.1	0.8	0.2	1.1	1.7
Triglycerides	0.5	0.8	0.9	0.9	0.9	0.9	1.0	1.0	0.7
Respiratory disease	0.5	1.2	3.4	-1.8	0.3	0.8	-0.6	-0.8	-1.4
Neuroticism	0.5	1.2	2.2	0.6	1.5	1.2	1.2	1.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.9	-0.8	1.2	1.2	0.9	1.4	0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.2	1.1	-0.2	0.0	-0.2	1.0	1.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.6	-0.2	-1.6	-0.8	-1.3	-0.9	0.8
Body mass index (BMI)	0.5	2.2	4.8	-2.2	1.3	1.3	0.2	1.2	-1.8
Qualifications: None of the above	0.5	1.1	3.0	-1.7	0.9	0.8	0.3	-0.4	-1.4
Financial difficulties in last 2 years	0.5	0.7	1.4	-1.0	0.7	0.7	-0.1	0.9	-1.2
Weight	0.5	2.2	3.3	-1.8	1.7	1.5	0.8	1.5	-1.4
Hip circumference	0.5	2.2	5.4	-2.3	1.0	1.1	-0.5	0.9	-2.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	0.7	-1.1	-1.3	-0.2	-0.5	1.0
Pulse rate	0.5	0.8	1.8	1.4	-0.0	-0.6	1.1	0.8	1.0
Asthma	0.5	0.9	1.7	-1.3	0.8	1.0	0.6	-0.6	-1.3
Arm fat mass (right)	0.5	2.2	3.7	-1.9	1.6	1.4	0.4	1.3	-1.7
Loud music exposure frequency	0.5	0.5	1.6	0.4	0.1	0.1	0.8	1.3	0.8
Gout (self-reported)	0.5	0.7	2.3	-1.0	0.0	0.1	-0.7	-0.6	-1.5
Health satisfaction	0.5	0.6	1.0	0.1	0.8	1.0	0.9	1.0	0.4
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	1.3	-0.9	-0.9	-0.8	-1.1	0.3
Medication: Ibuprofen	0.5	0.6	1.4	-0.6	1.0	1.2	0.3	0.7	-0.4
Medication: Allopurinol	0.5	0.7	1.2	-0.5	-0.9	-0.9	-1.1	-0.7	-1.0
Whole body fat mass	0.5	2.3	3.4	-1.9	1.8	1.6	0.4	1.2	-1.7
Pulse rate, automated reading	0.5	1.6	3.6	1.9	1.1	0.5	1.5	1.0	1.2
Knee pain experienced in last month	0.5	0.7	1.8	-0.5	0.8	1.0	0.3	1.3	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	0.6	-0.8	-0.6	-0.2	0.7	1.2
Smoking status: Previous	0.5	0.8	1.8	-1.4	-0.1	0.3	-1.2	-0.6	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	-1.2	-0.3	-0.0	-1.0	-0.5	-0.8
Mineral and other dietary supplements	0.5	0.7	1.2	0.4	-0.9	-1.0	-0.9	-1.1	0.1
Asthma (self-reported)	0.5	1.1	2.2	-1.4	0.8	1.0	0.3	-0.6	-1.5
Arm fat mass (left)	0.5	2.2	4.0	-2.0	1.6	1.4	0.4	1.2	-1.8
Ever taken oral contraceptive pill	0.5	0.5	0.6	0.6	0.6	0.8	0.8	0.8	0.8
High cholesterol (Self-reported)	0.5	0.9	2.4	-1.6	-0.5	-1.0	-0.6	-0.5	-1.0
Myopia	0.5	0.7	1.5	1.1	-0.7	-0.8	0.7	0.3	1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	0.6	0.7	1.0	0.1	0.8	0.9
Supplements: Calcium	0.5	0.6	1.0	-1.0	0.6	0.4	0.9	0.3	-1.0
Bipolar Disorder (2018)	0.4	0.7	3.1	0.0	1.8	1.1	0.0	0.0	0.0
Alzheimer’s Disease (including proxy)	0.4	0.5	0.8	-0.8	-0.6	-0.5	-0.7	-0.9	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.2	-1.5	-0.2	-0.3	-0.9	0.4	-0.8
Number of treatments/medications taken	0.4	0.7	1.7	-1.3	0.9	0.4	0.6	0.9	-0.8
Average weekly spirits intake	0.4	0.5	1.2	-0.1	-0.9	-0.4	-1.1	-0.6	-0.3
Stomach or abdominal pain in last month	0.4	0.5	1.7	0.2	0.1	-0.5	1.3	0.5	0.7
Nervous feelings	0.4	0.7	1.6	-0.5	1.2	1.3	0.7	0.4	-0.5
Arm fat percentage (right)	0.4	1.4	2.8	-1.5	1.3	1.1	0.2	0.8	-1.7
Number of live births	0.4	0.6	2.4	-0.0	-0.7	-0.5	-1.6	-0.8	-0.2
Medication: Cholesterol lowering	0.4	0.7	2.3	-1.5	0.4	-0.0	-0.1	-0.8	-1.0
Length of working week for main job	0.4	0.4	1.0	-0.1	0.9	0.8	0.0	1.0	-0.1
Exposure to tobacco smoke at home	0.4	0.4	1.8	-0.8	0.1	-0.1	-0.2	-0.2	-1.4
Arm fat-free mass (right)	0.4	2.0	3.3	-1.8	1.4	1.2	1.3	1.8	-0.8
Worry too long after embarrassment	0.4	0.7	1.7	0.4	0.8	1.3	0.9	1.1	0.2
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.9	-0.7	-0.2	-0.9	-0.9	0.1
Medication: Omeprazole	0.4	0.5	1.9	1.0	-0.2	-0.1	-0.2	0.3	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	0.3	0.5	0.4	1.1	0.5	1.1
Arm predicted mass (right)	0.4	2.1	5.1	-2.3	1.4	1.2	1.0	1.4	-1.2
Arm fat percentage (left)	0.4	1.6	2.3	-1.3	1.5	1.4	0.6	1.1	-1.4
Long-standing illness, disability or infirmity	0.4	0.6	2.1	-1.4	0.3	0.1	0.1	-0.1	-1.2
Financial situation satisfaction	0.4	0.5	2.2	-0.5	0.4	0.1	0.0	-0.6	-1.5
Medication: Atorvastatin	0.4	0.5	1.3	-0.9	0.0	0.3	-1.1	-0.7	-0.8
Arm fat-free mass (left)	0.4	2.0	4.2	-2.0	1.3	1.1	0.8	1.7	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	-0.9	-0.5	-0.5	-0.9	-0.5	-0.8
Heart disease (siblings)	0.4	0.5	1.3	-1.1	0.1	0.3	-0.6	-0.5	-0.9
Arm predicted mass (left)	0.4	1.9	5.6	-2.4	1.1	0.9	0.5	1.3	-1.3
Worry (Nagel 2018)	0.3	0.6	1.1	0.2	0.9	1.0	0.8	1.0	-0.2
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	1.3	-0.8	-0.7	0.6	0.3	1.3
LDL Cholesterol	0.3	0.4	1.1	-0.7	-0.5	-0.5	-1.0	-0.4	-0.6
BMI	0.3	1.9	5.7	-2.4	0.6	1.0	-0.7	0.5	-1.8
Hand grip strength (left)	0.3	0.8	2.0	-1.4	-0.8	-0.5	-0.8	-0.8	-0.6
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	-0.9	-0.5	-0.2	-0.6	-0.6	-0.6
Vitamin and mineral supplements	0.3	0.4	0.7	0.9	-0.5	-0.6	-0.4	-0.8	0.1
Severe depression (siblings)	0.3	0.4	0.8	-0.4	0.5	0.9	0.8	0.6	-0.1
Leg fat-free mass (left)	0.3	1.7	4.1	-1.3	1.4	1.2	1.1	2.0	-0.3
Taking other prescription medications	0.3	0.4	1.3	-0.9	0.3	-0.2	0.6	1.1	-0.2
Leg predicted mass (left)	0.3	1.8	4.1	-1.3	1.4	1.2	1.1	2.0	-0.4
Hearing difficulty/problems with background noise	0.3	0.6	2.3	-1.5	-0.5	-0.4	-0.6	-0.4	0.2
Medication: Simvastatin	0.3	0.5	1.7	-1.3	0.8	0.4	0.2	0.3	-0.5
Father’s age at death	0.3	0.3	1.1	1.0	-0.6	-0.0	-0.1	-0.0	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.8	1.7	-0.0	-0.3	0.2	0.7	1.3
Impedance of arm (left)	0.3	1.4	6.3	2.5	0.4	0.2	0.6	-0.2	1.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.7	0.8	-0.8	-0.6	-0.8	-0.2	0.8
Medication: Paracetamol	0.3	0.6	2.2	-0.4	-0.2	-0.2	1.0	1.5	0.3
Glaucoma (self-reported)	0.3	0.3	0.6	0.1	-0.8	-0.6	-0.7	-0.5	0.0
Number of full brothers	0.3	0.4	0.8	-0.9	-0.4	-0.2	-0.9	-0.7	-0.5
Family relationship satisfaction	0.3	0.4	1.2	1.1	-0.6	-0.5	-0.5	-0.2	0.5
Whole body fat-free mass	0.3	1.5	2.8	-1.6	1.2	0.9	1.1	1.7	-0.5
Leg fat-free mass (right)	0.3	1.7	4.3	-1.2	1.3	1.2	1.1	2.1	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	-0.6	-0.2	-0.5	-0.3	-1.0	-0.6
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.3	-0.5	-0.5	-0.9	-0.8	-0.4
Medication for cholesterol	0.3	0.5	1.9	0.5	0.6	1.4	0.5	0.1	-0.3
Osteoporosis (self-reported)	0.3	0.4	1.4	1.2	-0.3	-0.4	0.7	0.3	0.6
Osteoarthritis (self-reported)	0.3	0.4	1.2	-0.4	1.1	0.6	0.4	0.7	-0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.5	-0.2	-0.1	0.3	-0.2	-1.0	-1.2
Whole body water mass	0.3	1.5	2.7	-1.6	1.2	0.9	1.1	1.6	-0.5
Leg predicted mass (right)	0.3	1.8	4.3	-1.3	1.3	1.2	1.1	2.1	-0.3
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.8	-0.1	-0.2	0.6	0.5	0.8
Basal metabolic rate	0.3	1.8	3.3	-1.6	1.4	1.2	1.1	1.8	-0.6
Number of operations (self-reported)	0.3	0.4	1.0	0.7	0.4	1.0	0.4	0.5	0.4
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.9	-0.6	-0.9	-0.1	-0.4	0.6
Major Depression (MDD)	0.2	0.3	1.1	0.7	1.1	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.2	0.7	-0.3	-0.8	-0.8	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.2	1.0	3.6	0.5	-1.1	-1.9	-0.2	-0.6	0.7
Lung FVC	0.2	1.1	2.5	1.6	1.0	1.0	0.5	1.0	0.8
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.2	-0.7	-0.8	-0.7	-0.4	-0.3
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.2	0.1	0.4	0.1	0.8	0.7
Relative age voice broke	0.2	0.3	0.9	-0.4	0.6	1.0	0.5	0.2	-0.5
Age when periods started (menarche)	0.2	0.5	0.8	0.8	-0.4	-0.9	-0.2	-0.6	0.8
Supplements: Glucosamine	0.2	0.3	0.7	-0.6	0.6	0.4	0.8	0.4	0.3
High blood pressure (mother)	0.2	0.3	0.6	0.2	-0.5	-0.8	-0.4	-0.4	0.4
Had menopause	0.2	0.2	1.1	-0.3	0.0	0.5	-1.0	0.1	-0.1
Had other major operations	0.2	0.3	0.6	0.8	-0.3	0.2	-0.7	-0.1	0.5
Forced vital capacity (FVC)	0.2	0.7	1.0	1.0	0.9	0.7	0.9	1.0	0.5
Impedance of arm (right)	0.2	0.9	4.5	2.1	0.1	-0.1	-0.2	-0.7	0.6
Trunk fat-free mass	0.2	0.9	2.3	-1.5	0.8	0.5	0.9	1.0	-0.4
Alcohol intake versus 10 years previously	0.2	0.2	0.8	-0.9	-0.4	-0.2	-0.4	0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.5	1.2	0.1	-0.4	0.5	0.8	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	0.2	-1.1	-0.8	-0.6	0.2	0.4
Medication: Lansoprazole	0.2	0.3	1.1	0.1	-0.2	0.1	0.2	1.1	0.6
Trunk predicted mass	0.2	0.9	2.4	-1.6	0.8	0.5	0.9	1.1	-0.4
Pulse wave reflection index	0.2	0.2	0.6	0.5	-0.5	-0.8	-0.2	-0.4	0.4
Birth weight	0.2	0.5	1.3	0.4	-0.8	-1.1	0.1	-0.8	-0.2
Exposure to tobacco smoke outside home	0.2	0.3	0.9	-0.4	1.0	0.6	0.1	-0.1	0.3
Comparative body size at age 10	0.2	0.6	2.0	0.8	-0.4	-0.3	0.5	0.8	1.4
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	-1.1	-0.3	-0.1	-0.1	-0.3	-0.6
Age at first live birth	0.2	0.4	0.7	0.4	0.0	0.1	0.9	0.8	0.8
Migraine (self-reported)	0.2	0.3	0.6	0.3	0.4	0.7	-0.0	-0.8	-0.5
Suffer from ‘nerves’	0.2	0.3	0.8	0.2	0.9	0.7	0.7	0.4	-0.2
Had major operations	0.2	0.2	0.4	0.7	0.1	0.3	0.1	0.4	0.6
Age at last live birth	0.2	0.3	0.9	-0.9	-0.2	0.2	-0.3	-0.3	-0.8
Average weekly red wine intake	0.2	0.3	0.7	-0.6	0.6	0.3	0.8	0.1	-0.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.8	-0.9	0.7	0.3	0.3	0.6	-0.4
Guilty feelings	0.2	0.3	0.6	-0.3	-0.8	-0.6	-0.4	-0.6	0.4
Wears glasses or contact lenses	0.2	0.2	0.7	0.1	0.1	0.5	0.8	0.5	0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.3	-0.1	0.1	-0.8	-0.6	-0.4
Medication: Paracetamol	0.2	0.4	0.7	-0.4	-0.8	-0.8	0.4	0.8	0.0
Alcohol drinker status: Never	0.2	0.2	0.6	-0.4	-0.2	0.4	-0.8	-0.1	-0.6
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.7	0.2	0.7	-0.1	0.2	-0.9
Impedance of whole body	0.2	0.8	3.8	1.9	0.7	0.6	0.3	-0.3	0.4
Ovarian Cancer	0.1	0.1	0.3	0.3	-0.3	-0.0	-0.2	-0.2	0.6
Neuroticism (2016)	0.1	0.1	0.4	0.1	-0.4	-0.2	-0.1	0.3	0.6
Height	0.1	1.9	4.6	-0.5	2.1	1.8	1.4	1.1	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.6	0.0	-0.2	-0.3	-0.1	-0.2	0.8
Relative age of first facial hair	0.1	0.3	0.5	0.2	0.6	0.5	0.6	0.7	0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.3	-0.3	-0.1	-0.3	0.1	-0.4
Diabetes (mother)	0.1	0.1	0.4	-0.2	0.5	0.2	0.2	-0.3	0.7
Impedance of leg (right)	0.1	0.6	1.4	1.2	0.9	0.8	0.2	-0.7	-0.1
Hand grip strength (right)	0.1	0.2	0.3	-0.5	0.4	0.4	0.6	0.6	-0.0
Townsend deprivation index at recruitment	0.1	0.1	0.5	-0.1	-0.4	-0.2	-0.7	-0.0	-0.4
Current tobacco smoking	0.1	0.1	0.2	0.4	0.4	0.1	-0.3	-0.4	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.1	-0.4	-0.3	-0.4	-0.2	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.4	0.3	0.3	-0.2	0.0	-0.3
Sitting height	0.1	0.6	1.4	-0.2	1.0	0.6	1.2	0.8	-0.4
Impedance of leg (left)	0.1	0.5	1.1	1.0	0.8	0.9	0.0	-0.4	-0.2
Medication: Ramipril	0.1	0.1	0.6	0.1	0.3	0.1	-0.7	0.2	0.1
Happiness	0.1	0.2	0.5	0.7	-0.5	-0.3	0.1	-0.2	0.2
Standing height	0.1	0.6	1.3	0.4	1.1	0.6	1.1	0.6	0.3
Tense / ‘highly strung’	0.1	0.1	0.3	-0.5	0.0	0.5	0.1	0.4	0.0
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	1.0	0.6	0.6	0.3	0.6	0.5
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.5	-0.1	-0.4	0.5	-0.1	0.2
Alcohol intake frequency.	0.1	0.3	1.1	0.7	-0.0	0.3	-0.3	1.1	0.3
Comparative height size at age 10	0.1	0.5	1.8	-1.4	0.7	0.0	0.1	-0.1	-0.9
Number of full sisters	0.1	0.1	0.6	-0.3	-0.0	-0.3	-0.8	-0.0	-0.2
Chest pain or discomfort	0.1	0.1	0.3	-0.6	0.2	0.4	-0.1	0.2	-0.4
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.1	-0.3	-0.7	0.2	0.4	0.5
Loneliness, isolation	0.1	0.1	0.4	0.3	0.2	0.3	-0.1	0.6	0.1
Friendships satisfaction	0.1	0.1	0.3	-0.0	-0.6	-0.4	-0.3	-0.0	-0.0
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.2	-0.0	0.1	-0.5	-0.3	-0.0
Smoking status: Current	0.1	0.2	0.3	0.3	0.5	0.3	-0.4	-0.4	-0.6
Medication: Bendroflumethiazide	0.1	0.2	0.6	0.1	0.2	-0.1	-0.5	-0.4	-0.8
Medication: Lisinopril	0.1	0.2	0.3	-0.6	0.4	0.5	0.2	0.0	-0.6
Ever depressed for a whole week	0.1	0.1	0.4	-0.1	0.4	0.6	0.5	0.1	-0.0
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	-0.2	0.5	0.7	0.5	-0.1	-0.0
Ulcerative Colitis (UC)	0.0	0.1	0.3	0.1	-0.1	0.0	0.5	0.2	-0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.1	0.0	0.3	0.0	0.0	0.0
Hair Pigment	0.0	0.5	1.0	0.0	0.3	0.2	0.9	1.0	0.9
Tanning	0.0	0.1	0.3	0.3	-0.5	-0.3	-0.0	0.2	0.4
Multivitamins +/- minerals	0.0	0.0	0.1	-0.1	0.3	0.0	0.1	-0.1	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.1	0.4	0.5	0.2	0.1	-0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.2	-0.3	-0.1	-0.1	-0.1	0.3	-0.4

Hub : Genes

AK1

Models

Trait associations