TWAS hub - C9orf16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1280	0.0420	0.00022	0.046	NA	0.054	NA	0.039	0.00047	NA	0.00018	NA	0.0013
2	ROSMAP	Brain Pre-frontal Cortex	0.0323	0.0193	0.03400	0.001	0.00	0.000	0.002	-0.002	0.26000	0.3600	0.36000	0.16	0.6700
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0940	0.0460	0.00026	0.034	0.04	0.012	NA	0.019	0.00500	0.0025	0.06200	NA	0.0270

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Long-standing illness, disability or infirmity	9.0	13.8	15.0	3.8	3.9	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.8	8.0	9.2	3.0	2.5	2.9
Hearing difficulty/problems with background noise	5.8	9.2	10.6	3.2	2.6	3.3
Stomach or abdominal pain in last month	5.7	7.1	12.6	3.5	2.0	2.2
Noisy workplace	5.5	6.8	8.9	2.4	2.4	3.0
Vitamin and mineral supplements	5.3	7.2	16.8	0.8	4.1	2.0
Multivitamins +/- minerals	5.3	6.7	13.6	-1.3	-3.7	-2.2
Ever unenthusiastic/disinterested for a whole week	4.7	5.7	7.5	2.5	2.7	1.8
Falls in the last year	4.5	6.1	8.3	2.7	1.8	2.9
Medication: Paracetamol	4.3	6.7	9.0	3.0	2.0	2.6
Ever depressed for a whole week	3.9	4.8	5.2	2.3	2.0	2.3
Major Depression (MDD)	3.8	4.7	11.4	3.4	1.6	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	7.1	2.7	-0.1	2.5
Eye problems/disorders: Cataract	3.7	4.3	5.2	1.9	2.0	2.3
Tinnitus: Yes, now most or all of the time	3.6	4.2	6.1	1.8	1.7	2.5
Hearing difficulty/problems: Yes	3.5	5.4	7.6	2.3	1.9	2.8
Medication: Ventolin 100micrograms inhaler	3.5	4.5	9.4	3.1	0.6	1.9
Medication: Seretide 50 evohaler	3.5	4.0	8.6	2.9	0.6	1.8
Deep venous thrombosis (DVT) (self-reported)	3.5	4.5	5.8	2.0	2.4	1.9
Heart disease (siblings)	3.5	4.3	11.3	0.3	3.4	1.2
Gout (self-reported)	3.3	4.5	6.1	2.3	2.5	1.4
Medication: Metformin	3.2	4.5	7.5	-2.3	-0.8	-2.7
Illnesses of siblings	3.2	4.6	10.0	-1.2	-3.2	-1.5
Blood clot in the leg (DVT)	3.2	4.1	6.0	1.9	2.4	1.6
Mouth/teeth dental problems: Dentures	3.1	5.2	7.2	2.3	2.7	1.8
Loneliness, isolation	3.1	4.3	10.5	-1.5	3.2	-0.4
Chronic bronchitis/emphysema (mother)	3.0	3.5	4.6	-2.1	2.1	-1.2
Eye problems/disorders: None of the above	3.0	3.5	6.3	-1.4	-2.5	-1.5
Serious illness, injury or assault to yourself	2.8	3.4	5.8	2.1	2.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	10.5	1.5	3.2	0.9
Medication: Omeprazole	2.8	3.3	7.1	1.3	2.7	1.0
Age started oral contraceptive pill	2.7	3.4	8.3	2.9	-0.4	1.4
Pain type(s) experienced in last month: Hip pain	2.5	3.2	8.2	0.7	2.9	1.0
Body Mass Index (BMI) (2010)	2.4	3.3	8.9	0.3	3.0	0.9
Allergy or Eczema	2.4	6.4	9.5	3.1	2.3	2.1
Pain all over the body in last month	2.4	2.6	4.1	-2.0	1.0	-1.6
Medication: Allopurinol	2.4	3.1	4.3	2.1	1.8	1.4
Leg pain on walking	2.4	3.1	4.9	2.2	0.9	1.9
Supplements: Vitamin C	2.4	2.9	7.0	-0.9	-2.6	-0.9
High blood pressure (mother)	2.3	3.3	9.1	-0.5	3.0	0.7
Arm fat percentage (right)	2.3	9.1	12.2	2.1	3.2	3.5
High blood pressure (siblings)	2.3	3.3	4.5	1.1	2.1	2.0
Blood White Count	2.2	16.4	28.6	3.0	3.4	5.3
Financial difficulties in last 2 years	2.2	3.0	4.3	2.1	1.1	1.8
Illnesses of mother	2.2	2.7	5.8	-0.3	-2.4	-1.5
Number of full brothers	2.2	2.8	5.0	1.5	2.2	1.2
Wheeze or whistling in the chest in last year	2.2	4.0	5.4	1.5	2.3	2.1
Number of self-reported non-cancer illnesses	2.2	3.8	7.6	2.8	1.7	1.0
Body mass index (BMI)	2.1	9.0	13.0	1.3	3.5	3.6
Ever highly irritable/argumentative for 2 days	2.1	2.6	4.6	0.4	2.1	1.7
Illnesses of father: High blood pressure	2.0	2.5	4.4	1.7	-0.5	2.1
Risk taking	2.0	3.0	5.9	1.5	0.8	2.4
Alzheimer’s Disease (in mother)	1.9	2.3	3.8	2.0	0.7	1.6
Coronary Artery Disease (CAD)	1.9	2.3	3.5	1.8	1.9	0.0
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.9	1.2	2.2	1.0
Diabetes (self-reported)	1.9	2.9	5.3	-2.3	-0.1	-1.8
Arm fat percentage (left)	1.9	7.4	10.0	1.9	3.0	3.2
Commuting to job workplace: Public transport	1.9	2.3	5.3	-0.5	-2.3	-1.1
Vascular/heart problems diagnosed by doctor	1.9	5.1	7.6	2.8	-2.1	1.7
BMI	1.8	10.7	17.0	1.5	4.1	3.6
Health satisfaction	1.8	2.3	3.9	2.0	1.4	1.1
Leg fat mass (right)	1.8	7.0	9.7	1.3	3.1	3.1
Overall health rating	1.8	3.9	7.4	1.9	2.7	0.9
Mineral and other dietary supplements	1.8	2.4	6.7	-0.0	2.6	0.6
Average weekly champagne plus white wine intake	1.8	2.5	5.8	-1.1	-2.4	-0.8
Age at First Birth	1.7	2.5	7.2	0.3	-2.7	0.5
Age when periods started (menarche)	1.7	4.1	5.6	-2.4	-1.9	-1.7
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	5.0	0.7	2.2	0.6
Arm fat mass (right)	1.7	7.0	10.8	1.3	3.0	3.3
Leg fat percentage (right)	1.7	6.1	10.9	1.1	3.3	2.5
Hypertension (Self-reported)	1.7	4.8	8.9	-3.0	1.4	-1.9
Leg fat mass (left)	1.7	6.5	9.4	1.2	3.1	3.0
Prospective memory result	1.6	1.9	4.1	-0.1	-2.0	-1.3
Medication: Gliclazide	1.6	1.8	2.8	-1.4	0.8	-1.7
Arm fat mass (left)	1.6	6.6	10.5	1.3	2.7	3.2
Leg fat percentage (left)	1.6	5.9	10.9	1.0	3.3	2.4
Depressed Affect (Nagel 2018)	1.5	3.2	8.5	-0.6	2.9	1.0
Number of treatments/medications taken	1.5	2.7	3.7	1.9	1.6	1.3
Supplements: Zinc	1.5	1.7	4.5	0.6	-2.1	0.2
Relative age voice broke	1.5	2.3	3.0	-1.0	-1.7	-1.7
High blood pressure	1.5	4.2	8.2	-2.9	1.2	-1.7
Waist circumference	1.5	5.6	9.1	1.0	3.0	2.6
Mouth/teeth dental problems	1.5	2.3	5.7	-0.6	-2.4	-0.9
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.0	-1.7	-1.3	-1.1
Worry too long after embarrassment	1.5	2.5	4.3	1.6	2.1	0.6
Number of children fathered	1.5	1.7	2.7	1.7	0.2	1.5
Medication: Bendroflumethiazide	1.5	2.2	3.3	-1.4	1.8	-1.2
Alzheimer’s Disease (in father)	1.4	1.6	3.6	-0.8	-1.9	-0.6
Sensitivity / hurt feelings	1.4	2.4	4.3	0.2	2.1	1.6
Hayfever, allergic rhinitis or eczema	1.4	3.1	4.9	2.2	1.2	1.7
Hip circumference	1.4	6.0	9.0	1.4	3.0	2.6
Medication: Lansoprazole	1.4	1.6	2.5	1.6	1.0	1.1
Pulse wave reflection index	1.4	1.7	3.7	-1.9	-0.1	1.2
Medication: Paracetamol	1.4	2.3	2.9	1.5	1.7	1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.5	2.3	1.0	1.5	1.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.5	-1.2	-1.9	-0.4
Mood swings	1.4	2.5	4.7	-0.1	2.2	1.7
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.6	-0.6	-2.1	-0.8
Fractured/broken bones in last 5 years	1.4	1.8	2.4	1.0	1.5	1.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.7	1.0	1.9	0.6
Diabetes (father)	1.3	1.7	4.7	-2.2	-0.5	-0.2
Alcohol intake versus 10 years previously	1.3	2.0	5.2	0.6	2.3	-0.6
Depression (self-reported)	1.3	1.6	4.1	0.7	2.0	0.4
Body fat percentage	1.3	5.1	7.7	1.0	2.8	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	5.0	2.2	-0.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.2	-0.2	2.0	0.7
Qualifications: nursing, teaching	1.3	2.1	4.4	2.1	0.6	1.2
Medication: Atorvastatin	1.3	1.6	4.2	-0.7	2.0	0.3
Pulse rate	1.2	2.1	4.2	1.3	2.1	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.6	1.6	0.3	1.1
Hearing aid user	1.2	1.4	2.9	0.5	1.7	1.0
Medication: Blood pressure	1.2	2.3	2.9	-1.6	1.2	-1.7
Unable to work because of sickness or disability	1.2	1.6	2.4	1.3	1.6	0.9
Neuroticism (2016)	1.1	1.6	4.8	-2.2	0.1	-0.3
Chronic bronchitis/emphysema (father)	1.1	1.3	3.1	0.2	-0.9	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	2.9	1.7	1.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.8	1.4	1.7	0.6
Emphysema/chronic bronchitis	1.1	1.3	3.3	1.8	-0.1	0.7
Whole body fat mass	1.1	4.5	7.3	0.8	2.3	2.7
Ever taken oral contraceptive pill	1.1	1.2	1.7	0.9	1.1	1.3
Ovarian Cancer	1.0	1.3	2.7	-1.0	0.6	-1.6
Diabetes (mother)	1.0	1.2	3.4	0.6	1.8	-0.1
Fed-up feelings	1.0	1.9	5.1	-0.7	2.3	0.4
Had menopause	1.0	1.2	2.2	-1.5	0.5	-1.1
Tense / ‘highly strung’	1.0	1.6	4.0	0.8	0.2	-2.0
Peak expiratory flow (PEF)	1.0	2.2	4.6	-2.2	1.3	-0.5
Family relationship satisfaction	1.0	1.2	1.7	1.3	0.8	1.1
Financial situation satisfaction	1.0	1.3	2.0	0.6	1.4	1.2
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.3	0.1	-1.8	0.5
Hypothyroidism (self reported)	0.9	2.1	3.3	1.6	-0.7	1.8
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.6	0.4	1.9	-0.4
Trunk fat percentage	0.9	3.6	5.2	0.9	2.2	2.3
Allergy	0.9	2.0	3.2	-1.8	-1.2	-1.2
Hair/balding pattern: Pattern 3	0.9	1.3	2.3	-1.1	-0.6	-1.5
Medication: Ibuprofen	0.9	1.1	2.2	0.8	1.5	0.6
Pulse rate, automated reading	0.9	3.0	5.7	1.8	0.5	2.4
Age at last live birth	0.9	1.3	2.3	1.5	-1.3	-0.1
Pain experienced in last month	0.9	1.4	2.8	-0.6	-1.7	-1.1
Mean Putamen Volume	0.8	0.9	2.4	0.2	0.5	1.6
Systolic Blood Pressure	0.8	4.1	11.8	0.7	3.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.1	-0.8	1.1	1.1
Weight	0.8	3.9	7.0	0.6	2.1	2.6
Age at first live birth	0.8	1.4	2.0	1.4	-1.4	0.4
Neck or shoulder pain in last month	0.8	1.2	2.2	0.3	1.5	1.1
Alcohol intake frequency.	0.8	1.9	5.7	-0.0	2.4	-0.2
Guilty feelings	0.8	1.1	3.1	0.3	1.8	0.5
Ever smoked	0.8	1.4	3.8	-0.6	1.9	0.1
Bipolar Disorder (2018)	0.7	1.0	2.0	1.4	-0.6	0.9
LDL Cholesterol	0.7	1.1	1.9	1.4	0.1	1.2
Ulcerative Colitis	0.7	1.0	1.3	-1.2	0.8	-0.9
Blood Red Count	0.7	6.8	19.4	-0.8	4.4	0.6
Smoking Status	0.7	1.8	2.4	0.7	1.5	1.5
Systolic blood pressure, automated reading	0.7	1.9	5.6	0.2	2.4	-0.1
Current tobacco smoking	0.7	1.2	1.8	0.5	1.4	1.2
Supplements: Glucosamine	0.7	0.9	1.7	0.9	-1.3	0.4
Trunk fat mass	0.7	2.9	5.2	0.6	1.8	2.3
Nervous feelings	0.7	1.4	1.9	1.4	0.8	-1.3
Loud music exposure frequency	0.7	0.8	1.2	-0.9	0.6	1.1
Birth weight	0.7	1.5	4.2	0.3	-0.2	2.1
Heart disease (mother)	0.7	0.8	2.3	-0.5	1.5	0.1
Friendships satisfaction	0.7	0.8	2.3	-0.3	1.5	-0.3
Miserableness	0.7	1.2	2.5	-0.6	1.6	0.8
Number of operations (self-reported)	0.7	1.0	1.8	1.4	0.5	0.9
Impedance of whole body	0.7	3.7	9.1	-0.4	-1.4	-3.0
Bipolar Disorder or Schizophrenia	0.6	1.4	4.2	2.1	-0.2	-0.2
Depression (Nagel 2018)	0.6	0.9	1.4	1.2	1.2	-0.2
Neuroticism (Nagel 2018)	0.6	1.3	3.8	0.2	1.9	0.3
Rheumatoid Arthritis	0.6	0.8	2.0	0.1	0.7	1.4
Height	0.6	11.3	22.2	-2.5	-4.7	-2.3
Cardiovascular Disease	0.6	2.0	3.2	-1.6	1.8	-0.6
Respiratory disease	0.6	1.3	3.1	1.8	0.7	0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.2	0.8	0.7	1.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.0	0.4	1.4	-0.1
Angina	0.6	0.7	1.7	-0.4	1.3	0.6
Impedance of leg (right)	0.6	2.8	6.6	-1.0	-0.9	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.1	1.0	1.1	0.4
Impedance of leg (left)	0.6	3.0	7.3	-0.8	-1.0	-2.7
Past tobacco smoking	0.6	1.1	2.9	0.2	-1.7	-0.7
Happiness	0.6	0.7	1.9	0.2	1.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	1.2	0.7	0.5
Breastfed as a baby	0.6	0.7	0.9	-0.7	-0.8	-1.0
Pulse wave peak to peak time	0.6	0.8	1.6	-0.0	-0.8	-1.3
Shortness of breath walking on level ground	0.6	0.8	1.2	0.5	1.1	-1.0
Qualifications: College or University degree	0.6	1.8	3.9	0.4	-2.0	-1.2
Migraine (self-reported)	0.6	0.8	1.7	0.5	0.5	-1.3
Knee pain experienced in last month	0.6	0.9	2.3	0.3	1.5	0.4
Ever had bowel cancer screening	0.6	0.7	1.6	1.3	-0.7	0.4
Medication for cholesterol	0.6	0.9	1.8	0.8	-1.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.5	-0.2	-0.9	1.2
Breast cancer (self-reported)	0.6	0.7	1.4	-0.0	-1.2	-0.9
Commuting to job workplace: Cycle	0.6	0.8	1.6	-0.8	0.2	-1.3
Supplements: Calcium	0.6	0.7	1.7	0.5	-1.3	0.1
Schizophrenia (2018)	0.5	1.0	2.2	1.5	0.1	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	1.6	-0.3	1.2	-0.6
Blood Platelet Count	0.5	6.3	14.7	1.0	3.8	1.8
Average weekly spirits intake	0.5	0.6	1.4	-0.0	0.7	1.2
Average weekly fortified wine intake	0.5	0.6	1.5	-0.6	-1.2	0.2
Taking other prescription medications	0.5	0.8	2.0	1.4	0.2	0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.0	-0.8	0.1	-1.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.5	0.5	-1.2	-0.1
Had other major operations	0.5	0.6	0.8	0.7	0.8	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	0.0	0.7	1.1
Impedance of arm (left)	0.5	2.4	4.3	0.6	-1.6	-2.1
Standing height	0.5	5.3	9.2	-1.7	-3.0	-1.9
Length of working week for main job	0.5	0.5	1.0	-1.0	0.3	0.7
Birth weight of first child	0.5	0.9	2.6	-1.6	-0.2	0.1
Headache pain in last month	0.5	0.9	2.4	-0.4	1.6	-0.3
Angina (self-reported)	0.5	0.7	1.5	-0.2	1.2	0.7
Number of full sisters	0.5	0.6	1.6	0.4	1.3	0.2
Suffer from ‘nerves’	0.5	0.8	1.6	0.7	1.3	-0.5
Smoking status: Previous	0.5	0.7	1.1	-0.2	1.1	1.0
Diabetes diagnosed by doctor	0.5	0.9	1.5	-1.2	0.8	-0.7
Asthma (self-reported)	0.5	0.9	2.6	1.6	-0.2	0.3
Mother’s age at death	0.5	0.7	1.5	0.3	-1.2	0.7
Diastolic blood pressure, automated reading	0.5	1.6	4.6	0.4	2.1	0.4
Worry (Nagel 2018)	0.4	0.8	2.4	0.1	-0.2	-1.6
Irritable Bowel Disease (IBD)	0.4	0.9	1.3	-1.1	-0.4	-1.0
Breast Cancer	0.4	0.9	2.6	0.4	1.6	-0.2
Crohns Disease (2012)	0.4	0.6	1.3	-0.3	1.1	-0.6
Lung FEV1/FVC ratio	0.4	1.8	4.6	2.1	-0.9	0.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	-0.4	0.9	-0.6
Medication for hormone replacement therapy	0.4	0.5	1.1	0.5	0.1	1.1
Severe depression (siblings)	0.4	0.4	0.6	0.5	-0.8	-0.7
Pack years adult smoking proportion	0.4	0.5	1.6	1.3	0.2	-0.0
Townsend deprivation index at recruitment	0.4	0.5	0.8	0.2	0.9	0.8
Medication: Atenolol	0.4	0.5	1.5	-0.2	1.2	0.2
Sitting height	0.4	2.9	4.6	-2.1	-1.9	-0.9
Forced vital capacity (FVC)	0.4	1.6	2.4	-1.5	0.0	-1.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.7	0.6	-0.8	-0.6
Fluid intelligence score	0.4	0.7	1.7	-1.3	0.6	-0.3
Neuroticism score	0.4	0.9	2.6	-0.0	1.6	-0.0
Number of live births	0.4	0.5	1.3	0.5	1.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	-1.5	0.0	-1.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.2	0.5	-1.1	0.9
Medication: Amlodipine	0.4	0.5	1.5	0.0	1.2	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.8	0.9	0.4	0.7
Average weekly red wine intake	0.4	0.6	1.2	1.1	0.3	0.7
Commuting to job workplace: Walk	0.4	0.5	0.9	-0.5	1.0	-0.5
Osteoporosis (self-reported)	0.4	0.5	1.1	1.1	0.4	0.4
Osteoarthritis (self-reported)	0.4	0.5	1.0	1.0	0.7	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.0	1.1	-0.5
Smoking status: Current	0.4	0.6	1.5	-0.0	1.2	0.6
Average weekly beer plus cider intake	0.4	0.5	1.3	0.3	1.1	0.4
Myopia	0.4	0.5	1.4	0.1	-1.2	-0.5
Alcohol drinker status: Previous	0.4	0.4	1.0	-0.6	0.1	-1.0
Pack years of smoking	0.4	0.6	1.6	1.3	0.0	-0.2
Lupus	0.3	0.4	1.0	0.1	1.0	0.5
Schizophrenia (2014)	0.3	0.6	1.1	1.0	0.5	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.0	-0.1	1.0	0.0
Blood Eosinophil Count	0.3	2.4	3.6	-0.1	1.9	1.9
Neuroticism	0.3	0.7	1.6	-0.5	1.3	-0.2
Hand grip strength (left)	0.3	0.7	1.3	1.1	0.2	0.9
Leg fat-free mass (left)	0.3	1.7	4.4	0.6	0.7	2.1
Maternal smoking around birth	0.3	0.4	0.8	-0.1	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	-1.1	0.8	-0.4
Medication: Levothyroxine sodium	0.3	0.5	1.2	0.4	-1.1	0.3
Leg predicted mass (left)	0.3	1.8	4.5	0.6	0.8	2.1
Impedance of arm (right)	0.3	1.3	2.4	0.9	-0.9	-1.5
Time employed in main current job	0.3	0.4	0.5	-0.7	0.7	-0.4
Father’s age at death	0.3	0.4	1.2	0.1	-1.1	0.2
Asthma	0.3	0.6	1.8	1.3	-0.1	0.2
Exposure to tobacco smoke at home	0.3	0.4	0.9	-0.4	-0.9	0.0
Glaucoma (self-reported)	0.3	0.3	0.6	0.8	0.2	0.5
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-1.0	-0.1	0.4
Medication: Blood pressure	0.3	0.6	1.2	-1.1	0.3	-0.6
Medication: Aspirin	0.3	0.4	0.8	-0.6	-0.2	-0.9
Illnesses of father: Heart disease	0.3	0.4	0.6	0.7	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.5	0.2	-1.2	0.7
Leg fat-free mass (right)	0.3	1.3	3.3	0.5	0.7	1.8
Back pain experienced in last month	0.3	0.5	0.8	0.9	0.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.4	1.2	0.2	0.9
Alcohol drinker status: Never	0.3	0.4	0.6	-0.2	0.7	-0.8
Arm fat-free mass (left)	0.3	1.5	3.8	-0.1	0.9	1.9
Basal cell carcinoma (self-reported)	0.3	0.4	0.5	0.4	-0.7	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.4	0.6	0.7	0.6
Arm predicted mass (left)	0.3	1.7	4.2	0.1	0.9	2.1
Crohns Disease (2017)	0.2	0.5	1.1	-0.7	0.2	-1.1
Ulcerative Colitis (UC)	0.2	0.5	0.9	-1.0	0.1	-0.6
Fasting Glucose	0.2	0.2	0.4	-0.6	0.6	-0.1
HbA1C	0.2	0.2	0.3	0.6	-0.3	0.5
HDL Cholesterol	0.2	0.4	0.7	-0.6	0.1	0.8
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.4	0.7	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.8	0.3	-0.7
Chronotype (morning person)	0.2	0.4	1.1	0.2	0.2	-1.1
Relative age of first facial hair	0.2	0.3	0.5	0.4	-0.7	-0.6
Medication: Co-codamol	0.2	0.2	0.2	0.4	0.5	0.4
Number of incorrect matches in round	0.2	0.3	1.0	1.0	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-1.1	-0.4	-0.2
Medication: Ramipril	0.2	0.2	0.6	-0.8	-0.2	-0.3
Medication: Simvastatin	0.2	0.2	0.5	0.3	-0.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	0.5	-0.3	1.0
Hair/balding pattern: Pattern 4	0.2	0.4	0.5	-0.7	-0.7	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	0.6	-0.5	0.8
Arm fat-free mass (right)	0.2	0.8	1.9	-0.8	0.2	1.4
Mean time to correctly identify matches	0.2	0.4	0.6	0.8	-0.6	-0.3
Arm predicted mass (right)	0.2	0.8	2.0	-0.7	0.1	1.4
Whole body fat-free mass	0.2	0.9	2.6	-0.2	-0.1	1.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	0.3	0.6	0.6
Whole body water mass	0.2	0.9	2.7	-0.1	0.0	1.6
Leg predicted mass (right)	0.2	1.3	3.4	0.5	0.6	1.8
Wears glasses or contact lenses	0.2	0.2	0.6	0.4	-0.8	-0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.1	0.8	0.2
Basal metabolic rate	0.2	1.3	3.6	0.1	0.5	1.9
Irritability	0.2	0.3	0.6	-0.3	0.8	0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.2	-0.4	0.6
Reaction Time	0.1	0.3	0.6	0.8	-0.4	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.5	-0.6	-0.2
Triglycerides	0.1	0.2	0.4	-0.1	0.5	-0.7
Waist Hip Ratio (WHR)	0.1	0.3	0.6	-0.6	0.8	0.2
Tanning	0.1	0.7	1.0	0.9	-1.0	0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.1	-0.2	0.4	-0.3
Alcohol usually taken with meals	0.1	0.2	0.3	-0.3	-0.5	0.4
Qualifications: None of the above	0.1	0.2	0.2	0.5	-0.4	-0.4
Heart attack	0.1	0.2	0.3	0.4	0.5	0.3
Trunk fat-free mass	0.1	0.8	1.2	-0.7	-0.8	1.1
Worrier / anxious feelings	0.1	0.2	0.3	0.6	-0.3	-0.1
Lung cancer (father)	0.1	0.2	0.3	-0.2	-0.4	0.6
Trunk predicted mass	0.1	0.7	1.2	-0.7	-0.8	1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.0	0.1	0.8
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.9	-0.1	-0.6
Comparative body size at age 10	0.1	0.4	0.6	0.4	-0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	-0.7	-0.2	0.1
Comparative height size at age 10	0.1	0.4	0.8	0.1	-0.5	0.9
Had major operations	0.1	0.2	0.4	0.1	-0.2	0.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.1	-0.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.3	-0.5	-0.1
Medication: Aspirin	0.1	0.1	0.2	-0.2	0.2	-0.4
Medication: Lisinopril	0.1	0.2	0.3	-0.5	0.5	0.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.3	0.3	0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.1	0.1	0.2	-0.2	0.4
Lung FVC	0.0	0.1	0.3	-0.1	0.6	-0.3
Hair Pigment	0.0	0.3	0.5	0.6	0.3	0.7
Hand grip strength (right)	0.0	0.1	0.2	0.3	0.0	0.4
Medication: Cholesterol lowering	0.0	0.0	0.1	-0.0	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.4	-0.7	0.1	-0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.0	-0.0	0.0
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.1	0.4	0.1
Chest pain or discomfort	0.0	0.1	0.1	-0.1	-0.3	-0.3
High cholesterol (Self-reported)	0.0	0.0	0.1	0.0	-0.1	0.3
Cholesterol lowering medication	0.0	0.1	0.1	-0.0	0.2	-0.4

Hub : Genes

C9orf16

Models

Trait associations