TWAS hub - TMEM120B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1070	0.0380	7.6e-05	0.044	0.042	0.069	0.046	0.075	3.6e-06	6.0e-06	7.6e-09	2.6e-06	1.9e-09
2	GTEx	Artery Aorta	0.2020	0.0730	3.6e-04	0.150	NA	0.161	NA	0.030	1.2e-08	NA	3.5e-09	NA	8.3e-03
3	GTEx	Brain Cerebellum	0.2830	0.0960	3.4e-03	0.063	NA	0.039	NA	-0.010	6.2e-03	NA	2.6e-02	NA	9.0e-01
4	GTEx	Muscle Skeletal	0.0780	0.0299	8.9e-04	0.000	NA	-0.002	NA	-0.003	3.1e-01	NA	5.1e-01	NA	8.6e-01
5	GTEx	Thyroid	0.0950	0.0410	3.2e-03	0.044	NA	0.012	NA	0.041	2.6e-04	NA	3.5e-02	NA	4.2e-04
6	TCGA	Brain Lower Grade Glioma	0.0537	0.0282	4.1e-03	-0.002	0.023	0.012	NA	0.000	5.6e-01	1.1e-03	1.4e-02	NA	3.0e-01
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.1030	0.0570	6.8e-03	0.025	0.016	0.027	NA	0.022	7.6e-03	2.6e-02	5.9e-03	NA	1.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5	6	7
Blood Platelet Count	6.8	78.4	210.2	14.5	9.6	-11.0	-7.9	5.5	-5.7
Mood swings	5.3	9.6	27.9	5.3	5.1	-2.5	-2.1	1.2	-1.0
Mean Putamen Volume	4.6	5.3	12.5	3.5	2.3	-2.8	-3.0	1.3	-0.5
Qualifications: None of the above	4.2	8.9	17.8	4.2	1.9	-3.5	-4.0	2.5	-2.5
Fluid intelligence score	4.1	8.5	21.8	-4.2	-2.7	3.1	4.7	-1.1	1.6
Waist circumference	4.0	14.6	38.2	6.2	4.1	-5.2	-4.4	-0.2	1.2
Reason for reducing amount of alcohol drunk: Health precaution	3.9	4.5	12.1	1.7	-0.4	-1.2	-3.5	2.1	-3.2
Depressed Affect (Nagel 2018)	3.8	8.1	23.0	4.8	4.7	-2.7	-2.0	0.6	-0.4
Smoking Status	3.8	9.0	21.5	4.6	3.9	-4.2	-3.0	-0.2	0.4
Taking other prescription medications	3.7	5.8	17.1	4.1	2.6	-2.5	-3.1	-0.1	-0.7
Qualifications: A levels/AS levels or equivalent	3.3	7.3	17.6	-4.2	-3.1	3.1	3.1	-1.7	1.2
Prospective memory result	3.3	4.1	7.6	2.8	1.7	-1.9	-2.7	2.0	-1.8
Weight	3.1	15.4	31.0	5.6	4.4	-5.5	-4.7	0.1	2.2
Shortness of breath walking on level ground	3.1	3.7	17.1	2.6	4.1	-1.1	-0.3	0.9	-0.0
Arm fat-free mass (right)	3.0	15.4	46.3	4.6	3.3	-6.8	-5.1	1.1	1.5
Arm fat-free mass (left)	3.0	15.2	45.3	4.4	3.0	-6.7	-5.4	1.0	1.6
Leg fat mass (left)	3.0	11.9	28.8	5.4	4.2	-4.3	-3.5	-0.1	2.3
Heart attack/myocardial infarction (self-reported)	2.9	3.7	10.9	3.3	1.8	-2.7	-1.6	-1.4	0.1
Trunk fat mass	2.8	12.0	32.1	5.7	4.6	-3.8	-3.4	-0.3	1.8
Whole body fat mass	2.8	11.9	30.6	5.5	4.5	-4.0	-3.4	-0.4	2.1
Leg fat mass (right)	2.8	10.9	25.0	5.0	4.2	-4.0	-3.2	-0.5	2.6
Ever smoked	2.8	4.9	13.8	3.6	3.7	-1.7	-1.4	-1.3	0.7
Number of treatments/medications taken	2.7	4.9	14.1	3.8	3.1	-2.5	-1.6	-1.3	0.3
Heart attack	2.7	3.5	10.2	3.2	1.9	-2.5	-1.8	-1.2	0.2
Arm predicted mass (right)	2.7	13.7	41.4	4.3	3.1	-6.4	-4.8	1.0	1.7
Whole body fat-free mass	2.7	15.2	46.5	4.3	3.2	-6.8	-5.2	0.6	1.8
Leg fat-free mass (right)	2.7	14.3	41.2	4.7	3.4	-6.4	-4.7	0.5	1.5
Loneliness, isolation	2.7	3.8	13.1	3.1	3.6	-1.6	-1.1	-0.1	-0.3
Whole body water mass	2.7	15.3	47.1	4.3	3.2	-6.9	-5.2	0.7	1.9
Leg predicted mass (right)	2.7	14.2	40.9	4.7	3.3	-6.4	-4.7	0.5	1.5
Arm fat mass (left)	2.7	11.3	25.6	5.1	4.5	-4.0	-3.2	-0.3	2.5
Basal metabolic rate	2.7	15.2	43.3	4.6	3.4	-6.6	-5.1	0.5	2.0
Arm predicted mass (left)	2.7	14.0	40.5	4.2	2.9	-6.4	-5.2	1.1	1.6
Neuroticism (Nagel 2018)	2.6	6.0	21.0	3.8	4.6	-1.9	-1.6	0.2	0.1
Trunk predicted mass	2.6	14.7	48.0	3.9	2.9	-6.9	-5.2	0.6	1.9
Wheeze or whistling in the chest in last year	2.6	4.6	10.7	3.3	3.2	-1.8	-2.7	0.7	-0.5
Medication: Aspirin	2.6	3.5	8.7	2.8	1.6	-2.9	-2.1	-0.5	0.5
Long-standing illness, disability or infirmity	2.6	4.0	11.0	3.3	1.0	-3.2	-2.3	-0.0	-0.8
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	10.3	2.1	3.2	-0.8	0.5	0.3	1.8
Trunk fat-free mass	2.5	14.3	46.8	3.8	2.8	-6.8	-5.2	0.6	1.9
Pulse rate	2.5	4.2	13.3	2.5	2.5	-3.6	-1.3	-1.0	0.7
Arm fat mass (right)	2.5	10.4	23.7	4.9	4.4	-3.7	-3.1	-0.4	2.6
Leg fat-free mass (left)	2.4	12.6	36.1	4.3	3.3	-6.0	-4.3	-0.0	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.1	6.0	2.5	2.1	-2.1	-2.2	-0.6	-1.3
Leg predicted mass (left)	2.4	12.7	36.1	4.3	3.3	-6.0	-4.3	0.1	2.1
Supplements: Fish oil (including cod liver oil)	2.4	3.2	11.6	2.2	0.4	-0.8	-1.6	3.4	-1.6
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	10.8	1.0	3.3	-0.4	1.5	-1.1	2.2
Medication for hormone replacement therapy	2.3	2.6	5.6	2.2	2.4	-2.0	-0.5	-1.3	-1.2
Alcohol usually taken with meals	2.3	3.6	10.3	-3.1	-3.2	1.6	0.8	-0.2	1.5
Medication: Simvastatin	2.3	3.4	10.5	3.2	2.1	-2.4	-1.7	0.5	-0.3
Medication: Aspirin	2.3	3.0	7.2	2.7	1.5	-2.7	-2.0	-0.4	0.2
Body Mass Index (BMI) (2010)	2.2	3.0	8.5	2.5	2.9	-1.8	-1.5	-0.2	-0.5
Neuroticism	2.2	5.3	15.6	3.7	4.0	-2.1	-1.7	-0.6	0.3
Fed-up feelings	2.2	3.9	9.2	3.0	2.3	-2.3	-2.2	0.6	-1.7
Overall health rating	2.2	4.8	15.6	4.0	2.5	-2.5	-2.4	-0.2	-0.1
Intelligence (Savage-Jansen 2018)	2.1	6.5	19.8	-3.0	-2.4	3.0	4.5	-0.5	1.3
Verbal and Numeric Reasoning (VNR)	2.1	5.1	16.6	-2.5	-0.6	3.1	4.1	-0.6	1.5
Pulse wave Arterial Stiffness index	2.1	2.4	5.4	1.9	1.6	-2.0	-0.1	-1.2	2.3
Blood clot in the leg (DVT)	2.1	2.7	6.3	2.4	1.2	-2.5	-1.8	1.3	0.4
Exposure to tobacco smoke outside home	2.1	2.8	10.4	2.0	3.2	0.7	0.7	0.2	2.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	6.1	2.4	1.4	-2.5	-1.7	1.4	0.7
Ever used hormone-replacement therapy (HRT)	2.0	2.6	7.3	2.5	2.7	-1.5	-0.7	-1.2	0.1
Past tobacco smoking	2.0	3.7	10.7	-3.0	-3.3	1.4	1.3	1.5	-0.7
Hip circumference	2.0	8.5	17.9	4.2	3.4	-3.8	-2.9	-1.2	2.3
Commuting to job workplace: Car/motor vehicle	2.0	2.2	5.3	2.3	1.8	-1.1	-1.5	1.9	-0.5
Commuting to job workplace: Walk	2.0	2.2	7.3	-1.9	-1.7	2.7	0.8	-0.5	-0.9
Back pain experienced in last month	2.0	2.9	5.6	2.4	1.7	-1.7	-1.8	2.2	-0.8
Number of self-reported non-cancer illnesses	2.0	3.4	11.2	3.3	2.9	-1.1	-0.0	-1.3	1.1
Coronary Artery Disease (CAD)	1.9	2.2	7.6	0.0	0.0	0.2	1.2	-2.6	2.8
Trunk fat percentage	1.9	7.8	24.9	5.0	4.2	-2.2	-2.1	-0.5	1.4
Current tobacco smoking	1.9	3.2	8.2	2.4	1.8	-2.9	-2.2	-0.2	-0.1
Body mass index (BMI)	1.9	8.1	19.6	4.4	3.3	-3.6	-3.1	-0.3	1.9
Number of incorrect matches in round	1.9	3.2	6.4	2.1	2.4	-2.5	-2.1	-1.1	-0.9
Body fat percentage	1.9	7.4	22.6	4.8	4.0	-2.3	-2.2	-0.5	1.7
Health satisfaction	1.9	2.5	7.2	1.8	1.7	-1.6	-2.7	1.0	-0.7
Asthma (self-reported)	1.9	3.8	12.4	2.5	0.7	-3.5	-2.6	0.1	-1.0
Guilty feelings	1.9	2.9	8.0	2.8	2.1	-1.1	-2.3	0.6	-0.7
Multivitamins +/- minerals	1.8	2.3	5.4	2.3	1.0	-2.2	-1.4	1.1	-1.2
Qualifications: College or University degree	1.8	5.5	11.8	-3.0	-0.7	1.8	3.4	-2.5	2.8
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	8.9	2.5	1.4	-2.6	-3.0	1.1	-1.3
Arm fat percentage (left)	1.8	7.1	19.2	4.4	4.2	-2.1	-1.9	-0.6	2.2
Medication: Bendroflumethiazide	1.8	2.7	9.7	-0.8	0.3	0.7	3.1	-2.7	0.9
Age when periods started (menarche)	1.7	4.1	11.7	-2.5	-2.4	3.4	2.2	0.1	0.2
Arm fat percentage (right)	1.7	6.5	17.6	4.2	3.8	-2.0	-2.2	-0.6	2.0
Falls in the last year	1.7	2.3	6.5	2.5	2.2	-2.1	-0.6	-0.4	0.3
Breastfed as a baby	1.7	2.2	6.8	0.1	1.9	-0.3	2.6	-1.1	1.9
Smoking status: Current	1.7	2.6	7.1	2.1	1.8	-2.7	-1.9	-0.4	0.4
Average weekly champagne plus white wine intake	1.7	2.3	7.2	-2.7	-2.4	1.1	0.7	-0.4	1.3
Neuroticism score	1.6	3.4	13.6	2.7	3.7	-1.1	-1.2	-0.6	0.2
Asthma	1.6	3.2	10.9	2.2	0.5	-3.3	-2.4	-0.1	-0.8
Length of working week for main job	1.6	1.8	3.7	-1.9	-1.8	0.2	1.9	-1.3	-0.5
Medication: Amlodipine	1.6	2.3	5.1	-1.2	0.6	2.2	1.8	-1.5	1.8
Pulse wave peak to peak time	1.6	1.9	5.3	-1.7	-1.4	1.5	-0.1	1.1	-2.3
Medication: Ibuprofen	1.6	1.9	6.7	0.4	1.5	-1.4	1.0	-2.6	1.1
Comparative height size at age 10	1.6	8.8	28.3	3.3	4.4	-5.3	-1.7	-0.5	-0.1
Suffer from ‘nerves’	1.6	2.6	7.9	2.1	2.8	-1.5	-1.8	0.1	0.3
Mineral and other dietary supplements	1.6	2.2	5.9	-2.1	-0.9	0.8	1.6	-2.4	1.1
Commuting to job workplace: Public transport	1.6	1.9	6.2	-1.8	-1.5	2.5	0.4	-1.1	0.3
Leg fat percentage (left)	1.6	5.9	16.8	4.1	3.1	-2.6	-2.2	-0.2	1.9
Depression (Nagel 2018)	1.5	2.2	4.2	2.1	1.9	-1.9	-1.5	-0.5	-1.1
Bipolar Disorder (2011)	1.5	1.5	3.7	1.8	0.0	-1.9	-1.6	-0.7	-0.5
Ulcerative Colitis	1.5	2.2	8.1	0.0	-2.9	0.7	-2.1	1.3	-0.6
Height	1.5	29.0	61.8	6.9	7.5	-7.9	-5.7	0.7	2.0
Angina	1.5	1.9	5.2	2.0	2.3	0.0	0.1	-0.5	2.0
Medication: Metformin	1.5	2.2	5.7	2.4	0.5	-2.0	-2.2	-0.1	0.4
Financial difficulties in last 2 years	1.5	2.0	8.6	1.2	1.0	-1.0	0.9	-2.9	1.0
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.2	2.1	2.0	-1.4	-1.3	0.3	0.8
Pulse rate, automated reading	1.5	4.7	11.1	2.1	2.2	-2.5	-1.4	-2.1	3.3
Smoking status: Previous	1.5	2.2	7.1	2.5	2.7	-0.9	-1.0	-0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	4.2	-1.9	-1.4	2.0	1.9	-1.3	1.0
Hearing aid user	1.5	1.7	5.6	1.5	1.7	-2.4	0.1	-0.6	0.7
Townsend deprivation index at recruitment	1.4	1.9	5.4	1.8	0.3	-1.7	-2.3	-1.3	-0.3
Sitting height	1.4	10.1	38.6	3.0	2.8	-6.2	-3.7	0.7	1.1
Illnesses of siblings	1.4	1.9	7.3	-1.1	-1.2	0.2	-1.0	1.5	-2.7
Lung cancer (father)	1.4	1.7	4.3	0.8	0.4	-1.4	-2.0	0.8	-2.1
Leg fat percentage (right)	1.4	5.1	12.6	3.6	3.1	-2.1	-1.7	-0.9	2.4
Emphysema/chronic bronchitis	1.4	1.6	4.6	1.6	0.3	-1.4	-2.1	0.7	-1.1
Angina (self-reported)	1.4	1.9	5.0	2.0	2.2	-0.3	-0.1	-0.6	2.0
Medication: Omeprazole	1.4	1.6	6.9	1.1	2.6	-0.6	1.1	-0.4	1.2
Age at last live birth	1.4	2.0	5.9	0.1	-1.4	-1.9	-1.6	-0.2	-2.4
Irritability	1.4	2.4	6.2	1.5	1.6	0.7	-1.2	2.5	-1.8
Pack years of smoking	1.4	2.0	5.1	1.6	0.7	-2.3	-2.0	1.1	-0.6
Bipolar Disorder or Schizophrenia	1.3	3.1	8.0	2.3	2.6	-2.8	-0.5	-1.0	0.9
Schizophrenia (2018)	1.3	2.6	6.8	2.6	2.4	-2.2	-0.9	-0.1	0.4
Blood White Count	1.3	9.6	47.5	0.2	1.4	-3.3	0.8	-6.9	2.5
BMI	1.3	7.8	20.0	4.5	4.0	-3.3	-2.4	-0.4	1.4
Respiratory disease	1.3	2.9	9.0	2.5	1.3	-3.0	-1.9	0.3	-0.5
Ever had hysterectomy (womb removed)	1.3	1.5	3.6	0.6	-0.5	-1.9	-1.9	1.2	-1.1
High blood pressure (mother)	1.3	1.8	7.0	-1.0	-0.1	1.3	2.6	-1.1	1.2
Medication: Cholesterol lowering	1.3	2.1	5.6	2.4	0.7	-2.4	-1.5	-0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	6.4	1.6	2.5	-1.1	0.4	0.4	-0.3
Illnesses of father: None of the above (group 1)	1.3	1.6	6.2	0.0	-1.3	0.2	-0.8	1.6	-2.5
Average weekly beer plus cider intake	1.3	1.8	3.0	1.7	1.7	-0.7	-1.7	1.2	-1.5
Myopia	1.3	1.9	7.0	2.7	1.8	0.3	-1.4	0.8	-0.8
Pain experienced in last month	1.3	2.2	6.2	-2.1	-2.5	1.7	0.6	-0.9	-1.0
Basal cell carcinoma (self-reported)	1.3	1.5	3.4	1.6	-0.3	-0.9	-1.7	0.7	-1.8
Ulcerative Colitis (UC)	1.2	2.2	6.8	-0.4	-2.6	1.0	-2.4	1.2	-0.3
Average weekly spirits intake	1.2	1.5	3.7	1.9	1.0	-1.5	-1.1	1.0	-1.3
Sensitivity / hurt feelings	1.2	2.0	7.4	2.0	2.7	-1.1	-0.5	-1.0	-0.2
Pack years adult smoking proportion	1.2	1.8	4.4	1.5	0.5	-2.1	-2.1	1.0	-0.7
Relative age voice broke	1.2	1.8	5.2	-1.2	-1.7	2.3	1.3	-0.4	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	6.5	1.8	2.5	-1.1	-1.5	-0.2	-0.1
Had menopause	1.2	1.4	3.7	0.8	1.9	-0.9	1.7	-1.3	0.3
Pain all over the body in last month	1.2	1.3	5.6	1.4	2.4	-0.9	-0.1	-0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	4.8	2.2	2.1	-2.0	-0.5	0.2	0.0
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	7.6	-1.4	-0.8	2.7	1.5	-0.7	0.9
Family relationship satisfaction	1.2	1.5	4.8	1.2	2.2	-0.9	0.7	-0.8	1.5
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	5.8	-2.4	-1.4	1.1	0.5	0.1	0.8
Wears glasses or contact lenses	1.2	1.3	4.0	1.5	1.1	-2.0	-0.7	1.0	-0.6
Commuting to job workplace: Cycle	1.2	1.5	5.1	0.9	2.3	-0.7	0.9	-1.7	0.0
Systolic Blood Pressure	1.1	5.5	13.8	-3.1	-3.0	3.7	1.8	-1.6	0.7
Impedance of arm (right)	1.1	5.2	19.7	-1.8	-0.2	4.4	3.3	-1.4	-0.4
Impedance of arm (left)	1.1	5.0	18.7	-1.6	0.0	4.3	3.5	-1.1	-0.4
Illnesses of father: Heart disease	1.1	1.5	3.6	0.8	1.9	-1.4	0.0	-1.6	1.5
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.8	1.7	0.9	-1.7	-1.5	-0.0	-0.6
Diabetes diagnosed by doctor	1.1	1.8	5.6	2.4	1.7	-1.6	-1.2	0.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.3	0.4	0.5	-1.8	-1.2	-1.3	1.1
Qualifications: nursing, teaching	1.1	1.7	6.1	-1.5	-0.6	2.5	1.7	-0.5	0.6
Ever taken oral contraceptive pill	1.1	1.2	5.0	1.3	1.1	-0.0	-0.8	2.2	0.0
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.8	1.5	0.9	-1.9	-1.5	0.4	-0.2
Alzheimer’s Disease (including proxy)	1.0	1.4	4.7	1.6	2.2	-1.4	0.4	0.5	0.8
Ovarian Cancer	1.0	1.4	5.6	1.6	2.4	-1.1	0.3	0.3	-0.1
Fasting Glucose	1.0	1.3	5.2	0.8	2.3	-0.9	0.8	-1.1	0.6
Lupus	1.0	1.6	5.0	-1.1	-2.2	1.1	-1.8	0.0	-0.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	3.4	1.8	1.8	-1.2	-0.2	0.5	-0.6
Impedance of leg (right)	1.0	4.9	15.7	-2.7	-1.6	4.0	2.9	-0.5	-0.5
Chronic bronchitis/emphysema (father)	1.0	1.1	5.1	0.4	2.3	-0.8	1.0	-0.8	0.5
Happiness	1.0	1.2	2.4	0.7	1.3	-1.4	0.4	-1.5	1.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	5.6	-2.4	-1.4	1.3	0.5	1.3	-0.4
Comparative body size at age 10	1.0	2.9	8.5	2.2	2.3	-2.9	-0.3	-1.2	-0.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.6	0.0	0.3	2.2	0.5	-1.0	1.5
Number of full sisters	1.0	1.2	4.0	-1.0	-2.0	1.4	0.8	0.7	-0.2
Knee pain experienced in last month	1.0	1.6	5.1	2.3	1.4	-1.7	-0.9	0.1	0.7
Alcohol drinker status: Never	1.0	1.2	4.2	-1.5	-2.0	0.3	0.5	1.0	-0.8
Worry (Nagel 2018)	0.9	1.8	6.9	1.3	2.6	-1.0	-0.4	-1.4	1.1
Alzheimer’s Disease (in father)	0.9	1.0	2.3	-1.1	-0.2	1.1	1.5	0.1	1.4
Reaction Time	0.9	1.7	4.7	-1.3	-1.0	2.2	1.9	-1.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	6.6	-2.5	-2.6	0.4	-0.6	0.6	-0.3
Allergy	0.9	2.0	5.2	-1.8	-0.5	1.8	2.3	-0.9	1.1
Mouth/teeth dental problems: Dentures	0.9	1.5	2.7	1.6	1.6	-1.0	-1.6	1.0	-0.5
Hair/balding pattern: Pattern 4	0.9	2.1	4.0	-2.0	-0.9	1.1	1.8	-1.6	1.8
Loud music exposure frequency	0.9	0.9	4.0	0.6	-0.3	-0.9	-2.0	0.3	-1.1
Number of full brothers	0.9	1.2	3.7	-1.6	-1.9	1.3	0.3	-0.3	-0.1
Chest pain or discomfort	0.9	1.3	4.8	1.4	0.5	-1.4	-2.2	0.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.6	-1.4	-2.1	0.1	0.2	0.0	1.0
Osteoporosis (self-reported)	0.9	1.1	2.9	0.3	-1.7	0.1	-1.5	0.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.4	-1.8	0.2	2.1	1.1	1.4	1.7
Financial situation satisfaction	0.9	1.1	3.1	1.0	0.8	-1.8	-1.1	-0.9	0.7
High cholesterol (Self-reported)	0.9	1.7	5.8	2.1	2.4	-0.9	-0.3	0.3	0.6
Illnesses of father: High blood pressure	0.9	1.1	3.0	-1.0	-1.0	1.7	1.3	-0.2	1.2
Risk taking	0.9	1.4	3.8	1.7	0.5	-0.5	-1.6	-0.3	-1.9
Impedance of whole body	0.9	4.8	19.3	-1.6	-0.4	4.4	3.1	-0.4	-1.1
Schizophrenia (2014)	0.8	1.8	6.3	1.7	1.5	-2.5	-1.0	-0.2	0.3
Blood Eosinophil Count	0.8	5.8	20.8	0.6	1.5	-0.4	3.1	-4.6	2.7
Blood Red Count	0.8	7.5	28.5	0.9	-2.8	-1.9	-3.0	5.3	-1.9
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.3	1.8	1.4	-1.7	-0.8	-1.0	0.8
Hand grip strength (right)	0.8	2.1	9.4	0.7	1.1	-3.1	-1.3	1.3	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.0	1.4	1.3	-0.7	0.8	-1.3	-0.1
Mouth/teeth dental problems	0.8	1.3	4.4	-0.9	-1.5	0.1	-0.4	1.2	-2.1
Alcohol intake versus 10 years previously	0.8	1.2	2.7	-0.5	-1.1	-0.2	-1.3	1.6	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	3.0	1.7	1.7	-0.7	-0.7	1.0	-0.6
Standing height	0.8	8.3	23.2	3.1	2.8	-4.8	-4.0	0.9	0.7
Medication: Paracetamol	0.8	1.3	3.3	-0.5	0.4	0.6	1.3	-1.8	1.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-0.4	-1.0	0.9	-1.2	0.9	-1.3
High blood pressure (siblings)	0.8	1.2	3.5	1.0	1.3	-0.3	0.8	-1.1	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.6	1.9	1.4	-0.6	-0.3	-0.1	-1.0
Medication for pain relief, constipation, heartburn	0.8	1.4	4.3	-0.7	-1.2	0.9	-0.8	1.4	-2.1
Heart disease (mother)	0.8	1.0	3.2	0.3	-0.2	-1.7	-0.8	-0.5	1.8
Age started oral contraceptive pill	0.8	1.0	4.1	-1.5	-2.0	0.7	-0.2	0.1	0.0
Ever depressed for a whole week	0.8	1.0	3.8	0.2	1.3	-0.5	0.3	-2.0	0.9
Unable to work because of sickness or disability	0.8	1.0	3.7	1.7	1.9	0.2	0.4	0.0	-0.3
Cholesterol lowering medication	0.8	1.2	3.3	1.4	1.8	-0.8	-1.3	0.6	0.7
Heart disease (siblings)	0.8	1.0	4.5	-0.4	0.2	0.8	0.4	-1.2	2.1
Schizophrenia vs Biploar Disorder	0.7	0.9	4.3	-0.7	0.6	0.0	-0.0	-1.0	2.1
Crohns Disease (2017)	0.7	1.5	6.4	-0.0	0.4	2.5	1.1	1.1	1.1
Major Depression (MDD)	0.7	0.8	2.2	-0.9	-1.5	0.3	-0.3	-1.0	1.2
HDL Cholesterol	0.7	1.2	4.1	0.5	0.1	0.1	1.4	-2.0	1.5
Heel T-Score	0.7	5.4	17.8	-4.2	-3.6	1.6	0.4	1.3	-1.5
Cardiovascular Disease	0.7	2.4	5.6	0.0	1.3	2.4	2.0	-1.5	1.8
Hypothyroidism (self reported)	0.7	1.6	3.7	1.3	1.9	0.7	-1.3	0.3	1.8
Chronotype (morning person)	0.7	1.5	3.3	-0.8	-1.8	1.6	-1.6	1.1	-0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.8	0.9	1.9	-0.9	-0.4	-1.1	-0.6
Diabetes (father)	0.7	0.9	2.6	0.8	1.6	-1.6	0.4	-0.4	0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.8	0.5	1.1	-0.8	-0.0	-2.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.9	0.1	1.2	0.1	0.8	-1.6	1.7
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.5	1.9	1.4	-0.8	-0.1	-0.5	0.5
Headache pain in last month	0.7	1.3	3.4	1.2	1.0	-1.9	-0.6	0.7	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	1.4	1.5	-1.1	-0.1	-0.1	0.1
Medication: Gliclazide	0.7	0.8	2.6	1.3	0.2	-1.2	-1.6	-0.1	-0.2
Miserableness	0.7	1.3	3.7	1.9	1.7	-0.3	-0.6	-0.6	1.1
Medication: Paracetamol	0.7	1.1	3.5	-1.0	-0.2	0.2	1.2	-1.9	1.3
Bipolar Disorder (2018)	0.6	0.9	2.0	0.4	1.1	-1.4	0.2	-1.4	1.0
Alzheimer’s Disease (in mother)	0.6	0.8	2.7	0.5	1.6	-1.1	0.8	-0.3	0.6
Irritable Bowel Disease (IBD)	0.6	1.4	4.4	-0.2	-1.3	2.1	-1.0	1.6	0.1
Lung FVC	0.6	3.1	9.9	-2.2	-2.2	0.8	-1.2	3.1	0.2
Medication: Co-codamol	0.6	0.7	1.8	-0.2	1.2	0.4	0.3	-1.3	1.3
Average weekly fortified wine intake	0.6	0.7	2.2	-0.7	-0.4	-0.2	1.3	-1.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.5	4.3	-1.8	-2.1	0.9	-1.2	0.6	-0.5
High blood pressure	0.6	1.6	4.3	0.1	0.3	1.7	1.4	-2.1	1.4
Medication: Atenolol	0.6	0.7	2.2	0.8	1.5	-0.5	-0.0	-1.2	0.6
Impedance of leg (left)	0.6	2.8	9.4	-1.6	-1.2	3.1	2.0	0.4	-1.5
Nervous feelings	0.6	1.0	3.4	1.0	1.9	-1.4	-0.4	-0.9	0.1
Diabetes (self-reported)	0.6	0.9	2.0	1.4	1.3	-1.3	-0.3	0.1	0.7
Worrier / anxious feelings	0.6	1.2	3.1	-0.2	1.3	0.8	0.7	-1.8	1.5
Number of live births	0.6	0.9	3.8	0.1	-1.1	-1.9	-1.1	0.0	0.1
Noisy workplace	0.6	0.7	2.9	0.5	-0.2	-0.1	-1.7	1.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.6	0.7	1.1	-0.7	0.7	-1.6	0.7
Depression (self-reported)	0.6	0.7	2.8	1.3	1.7	0.4	0.1	-0.4	-0.1
Tense / ‘highly strung’	0.6	0.9	4.5	0.4	2.1	0.6	-0.7	0.2	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.1	1.1	2.0	0.3	-1.3	-0.4	1.3
Medication: Blood pressure	0.6	1.1	3.8	1.9	1.1	-0.7	-0.1	-1.6	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.8	-0.2	-1.3	-0.8	-0.9	-1.4	0.4
Hypertension (Self-reported)	0.6	1.6	4.4	0.5	0.9	1.5	1.6	-2.1	1.0
Osteoarthritis (self-reported)	0.6	0.8	3.2	1.8	0.9	-0.9	-0.6	0.7	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	-0.5	-1.4	0.2	-1.0	0.9	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.6	1.2	1.1	-1.1	0.3	-1.3	0.1
Neuroticism (2016)	0.5	0.7	2.4	1.1	1.6	0.2	-0.8	-0.4	0.5
Triglycerides	0.5	0.9	1.7	-0.6	-1.0	-0.7	-1.3	1.2	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.6	0.5	0.8	-1.3	-1.0	0.4	-0.5
Relative age of first facial hair	0.5	1.0	3.9	-0.5	-2.0	1.4	-0.0	-0.2	-1.0
Severe depression (siblings)	0.5	0.5	1.8	0.1	0.2	0.2	0.9	-1.3	1.0
Maternal smoking around birth	0.5	0.7	1.9	1.4	1.0	-0.0	-1.2	0.9	-0.1
Stomach or abdominal pain in last month	0.5	0.6	2.9	0.2	0.9	-0.4	0.1	-0.5	1.7
Medication: Levothyroxine sodium	0.5	0.9	2.3	0.9	1.4	-0.3	-1.5	-0.9	0.8
Time employed in main current job	0.5	0.6	1.6	0.1	1.1	-1.3	0.3	0.5	1.0
Illnesses of mother	0.5	0.6	2.0	0.4	1.4	0.1	-0.9	1.0	-0.7
Age at first live birth	0.5	0.9	5.0	0.3	0.4	0.6	-0.9	0.6	-2.2
Alcohol intake frequency.	0.5	1.2	3.0	-1.5	-1.7	0.1	1.5	-0.9	0.0
Diastolic blood pressure, automated reading	0.5	1.6	4.0	-0.9	-0.9	2.0	1.0	-1.7	1.2
Supplements: Calcium	0.5	0.6	1.9	0.8	0.8	-0.0	-1.4	0.6	-0.8
Alcohol drinker status: Previous	0.5	0.6	2.2	0.3	0.3	-1.5	-0.5	-0.2	1.1
Crohns Disease (2012)	0.4	0.7	2.1	0.6	0.9	1.4	0.8	0.4	0.8
Waist Hip Ratio (WHR)	0.4	1.7	4.5	2.1	-0.1	-1.1	-1.6	0.9	-1.6
Hand grip strength (left)	0.4	1.1	5.7	0.1	0.4	-2.4	-1.2	0.2	-0.3
Systolic blood pressure, automated reading	0.4	1.1	3.3	-0.8	-0.6	1.8	0.3	-1.3	1.1
Vitamin and mineral supplements	0.4	0.5	1.1	-1.0	-0.7	0.5	0.1	-0.9	1.0
Supplements: Zinc	0.4	0.5	1.6	1.2	1.0	-0.6	-0.6	-0.1	0.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	0.4	-0.3	-1.3	-0.6	-1.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.0	-0.6	-0.2	-0.9	-0.8	1.1
Serious illness, injury or assault to yourself	0.4	0.5	2.0	-0.5	-0.4	-0.2	0.9	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.7	-2.2	-0.8	0.9	0.2	0.6	1.3
Neck or shoulder pain in last month	0.4	0.5	1.8	0.0	1.3	0.6	0.4	0.9	0.6
Migraine (self-reported)	0.4	0.5	1.5	-0.1	-1.0	0.5	-0.2	1.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.6	0.1	0.2	0.4	0.2	-1.2	1.1
Had major operations	0.4	0.5	1.9	0.2	-0.1	-1.4	0.9	0.1	0.7
Friendships satisfaction	0.4	0.5	1.3	0.7	1.1	-1.1	-0.6	-0.3	0.3
Eye problems/disorders: Cataract	0.4	0.4	1.1	1.0	0.6	-0.7	-0.6	0.4	-0.6
Medication for cholesterol	0.4	0.7	3.0	-1.0	-1.7	0.6	0.2	0.6	-0.1
Breast cancer (self-reported)	0.4	0.5	1.5	-0.0	-1.2	-0.3	0.0	0.6	1.2
Mother’s age at death	0.4	0.6	2.6	-0.2	0.4	-1.6	-0.4	-1.0	-0.3
Number of operations (self-reported)	0.4	0.6	1.8	-0.4	-0.5	0.2	1.4	-0.5	1.2
Fractured/broken bones in last 5 years	0.4	0.5	1.1	-0.2	1.1	1.1	1.0	-0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.1	-0.9	-0.5	-1.1	-0.6	2.0	-1.3
Age at First Birth	0.3	0.4	1.2	-1.1	0.2	0.5	1.0	-0.3	0.7
HbA1C	0.3	0.3	1.1	-0.6	0.2	0.2	0.4	-1.0	0.7
Allergy or Eczema	0.3	0.8	3.2	1.4	1.8	-0.4	-0.2	-0.3	-0.3
Had other major operations	0.3	0.3	1.5	0.3	0.4	-0.5	0.4	-0.4	1.2
Forced vital capacity (FVC)	0.3	1.0	3.4	-0.3	0.2	-0.8	-1.9	1.5	0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	-0.5	-1.2	0.2	0.5	0.5	-0.8
Medication: Ramipril	0.3	0.4	2.8	0.4	-0.3	-0.1	-0.0	-1.7	-0.1
Birth weight of first child	0.3	0.5	2.2	-0.3	-0.3	-0.3	-0.2	1.5	0.9
Glaucoma (self-reported)	0.3	0.3	1.0	0.1	-0.4	0.6	-0.7	0.5	-1.0
Gout (self-reported)	0.3	0.4	1.4	0.0	-0.2	1.0	0.6	-0.0	-1.2
Birth weight	0.3	0.7	1.9	1.4	0.9	0.1	-0.6	1.3	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	3.6	-1.9	-0.9	0.4	-0.5	0.4	1.5
Worry too long after embarrassment	0.3	0.6	2.7	0.5	1.6	-0.7	0.1	-0.5	0.6
Medication: Allopurinol	0.3	0.4	1.7	0.1	-0.1	0.9	0.1	-0.6	-1.3
Mean time to correctly identify matches	0.3	0.7	2.7	-0.4	-0.6	1.6	1.0	-0.5	0.1
Supplements: Vitamin C	0.3	0.4	0.7	-0.8	-0.8	0.6	0.3	0.5	-0.9
Medication: Lisinopril	0.3	0.4	1.1	1.0	-0.2	-0.2	-1.0	0.5	-0.8
Medication: Atorvastatin	0.3	0.4	2.0	0.2	0.5	-0.4	0.7	-1.4	0.1
Primary Biliary Cirrhosis	0.2	0.3	1.2	-0.6	-0.4	-0.2	1.1	-0.0	-0.2
Diabetes (mother)	0.2	0.3	0.8	-0.9	-0.6	0.3	0.5	-0.2	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	0.8	0.5	-0.0	-1.0	0.4	-1.0
Supplements: Glucosamine	0.2	0.3	0.9	0.3	0.7	0.3	0.6	0.9	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	1.4	0.2	0.2	-0.4	0.2	-1.2	0.7
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	-0.1	-0.2	-0.3	-0.0	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	-0.9	0.0	0.2	-0.7	1.2	1.1
Exposure to tobacco smoke at home	0.2	0.3	0.6	0.4	0.7	-0.4	-0.6	-0.3	0.7
Peak expiratory flow (PEF)	0.2	0.6	2.6	-0.0	1.6	0.5	0.6	0.4	0.7
Pulse wave reflection index	0.2	0.2	1.2	0.4	-0.3	-0.0	-0.1	1.1	-0.5
Leg pain on walking	0.2	0.2	0.4	-0.4	-0.4	-0.5	-0.6	-0.3	0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.2	-0.8	0.8	0.7	0.3	0.1
Average weekly red wine intake	0.2	0.3	1.8	0.6	1.3	-0.3	0.0	-0.4	-0.2
Ever had bowel cancer screening	0.2	0.2	0.6	-0.2	0.4	0.6	0.7	-0.3	0.5
Medication: Blood pressure	0.2	0.4	1.1	0.0	0.8	1.1	0.8	-0.7	0.2
LDL Cholesterol	0.1	0.2	1.0	-0.3	-0.1	0.5	1.0	-0.5	0.1
Rheumatoid Arthritis	0.1	0.1	0.5	0.2	0.2	-0.2	0.3	-0.7	-0.4
Hair Pigment	0.1	1.5	3.8	1.9	1.4	-1.2	-1.3	0.4	-1.3
Hearing difficulty/problems: Yes	0.1	0.2	1.0	0.5	0.0	-0.4	-0.3	-1.0	0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.5	-0.2	0.4	-0.2	-0.7	-0.0	0.5
Father’s age at death	0.1	0.1	0.5	0.1	0.5	0.2	-0.1	-0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	0.5	0.5	-0.3	-0.4	-0.5	0.3
Medication: Lansoprazole	0.1	0.1	0.3	-0.4	-0.2	-0.2	0.3	-0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.7	0.4	-0.1	-0.1	-0.2	-0.7
Number of children fathered	0.1	0.1	0.9	-0.0	-0.0	0.2	-0.0	-0.2	0.9
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.4	-0.2	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.1	0.3	0.4	-0.2	0.6	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.0	0.2	0.7	-0.2	0.4	0.3	0.7	0.4	0.8
Tanning	0.0	0.5	1.8	1.2	1.3	0.2	-0.6	-0.0	0.3

Hub : Genes

TMEM120B

Models

Trait associations