Hub : Genes

TMEM120B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1070 0.0380 7.6e-05 0.044 0.042 0.069 0.046 0.075 3.6e-06 6.0e-06 7.6e-09 2.6e-06 1.9e-09
2 GTEx Artery Aorta 0.2020 0.0730 3.6e-04 0.150 NA 0.161 NA 0.030 1.2e-08 NA 3.5e-09 NA 8.3e-03
3 GTEx Brain Cerebellum 0.2830 0.0960 3.4e-03 0.063 NA 0.039 NA -0.010 6.2e-03 NA 2.6e-02 NA 9.0e-01
4 GTEx Muscle Skeletal 0.0780 0.0299 8.9e-04 0.000 NA -0.002 NA -0.003 3.1e-01 NA 5.1e-01 NA 8.6e-01
5 GTEx Thyroid 0.0950 0.0410 3.2e-03 0.044 NA 0.012 NA 0.041 2.6e-04 NA 3.5e-02 NA 4.2e-04
6 TCGA Brain Lower Grade Glioma 0.0537 0.0282 4.1e-03 -0.002 0.023 0.012 NA 0.000 5.6e-01 1.1e-03 1.4e-02 NA 3.0e-01
7 TCGA Ovarian Serous Cystadenocarcinoma 0.1030 0.0570 6.8e-03 0.025 0.016 0.027 NA 0.022 7.6e-03 2.6e-02 5.9e-03 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.6 0.9 2.0 0.4 1.1 -1.4 0.0 0.2 -1.4 1.0
Bipolar Disorder or Schizophrenia 1.3 3.1 8.0 2.3 2.6 -2.8 0.0 -0.5 -1.0 0.9
Depressed Affect (Nagel 2018) 3.8 8.1 23.0 4.8 4.7 -2.7 0.0 -2.0 0.6 -0.4
Depression (Nagel 2018) 1.5 2.2 4.2 2.1 1.9 -1.9 0.0 -1.5 -0.5 -1.1
Intelligence (Savage-Jansen 2018) 2.1 6.5 19.8 -3.0 -2.4 3.0 0.0 4.5 -0.5 1.3
Neuroticism (Nagel 2018) 2.6 6.0 21.0 3.8 4.6 -1.9 0.0 -1.6 0.2 0.1
Schizophrenia (2018) 1.3 2.6 6.8 2.6 2.4 -2.2 0.0 -0.9 -0.1 0.4
Schizophrenia vs Biploar Disorder 0.7 0.9 4.3 -0.7 0.6 0.0 0.0 -0.0 -1.0 2.1
Worry (Nagel 2018) 0.9 1.8 6.9 1.3 2.6 -1.0 0.0 -0.4 -1.4 1.1
Alzheimer’s Disease (in mother) 0.6 0.8 2.7 0.5 1.6 -1.1 0.0 0.8 -0.3 0.6
Alzheimer’s Disease (in father) 0.9 1.0 2.3 -1.1 -0.2 1.1 0.0 1.5 0.1 1.4
Alzheimer’s Disease (including proxy) 1.0 1.4 4.7 1.6 2.2 -1.4 0.0 0.4 0.5 0.8
Crohns Disease (2017) 0.7 1.5 6.4 -0.0 0.4 2.5 0.0 1.1 1.1 1.1
Irritable Bowel Disease (IBD) 0.6 1.4 4.4 -0.2 -1.3 2.1 0.0 -1.0 1.6 0.1
Ulcerative Colitis (UC) 1.2 2.2 6.8 -0.4 -2.6 1.0 0.0 -2.4 1.2 -0.3
Major Depression (MDD) 0.7 0.8 2.2 -0.9 -1.5 0.3 0.0 -0.3 -1.0 1.2
Reaction Time 0.9 1.7 4.7 -1.3 -1.0 2.2 0.0 1.9 -1.1 0.5
Verbal and Numeric Reasoning (VNR) 2.1 5.1 16.6 -2.5 -0.6 3.1 0.0 4.1 -0.6 1.5
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.0 1.4 5.6 1.6 2.4 -1.1 0.0 0.3 0.3 -0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 1.2 -1.1 0.2 0.5 0.0 1.0 -0.3 0.7
Bipolar Disorder (2011) 1.5 1.5 3.7 1.8 0.0 -1.9 0.0 -1.6 -0.7 -0.5
Body Mass Index (BMI) (2010) 2.2 3.0 8.5 2.5 2.9 -1.8 0.0 -1.5 -0.2 -0.5
Coronary Artery Disease (CAD) 1.9 2.2 7.6 0.0 0.0 0.2 0.0 1.2 -2.6 2.8
Crohns Disease (2012) 0.4 0.7 2.1 0.6 0.9 1.4 0.0 0.8 0.4 0.8
Mean Putamen Volume 4.6 5.3 12.5 3.5 2.3 -2.8 0.0 -3.0 1.3 -0.5
Fasting Glucose 1.0 1.3 5.2 0.8 2.3 -0.9 0.0 0.8 -1.1 0.6
HbA1C 0.3 0.3 1.1 -0.6 0.2 0.2 0.0 0.4 -1.0 0.7
HDL Cholesterol 0.7 1.2 4.1 0.5 0.1 0.1 0.0 1.4 -2.0 1.5
LDL Cholesterol 0.1 0.2 1.0 -0.3 -0.1 0.5 0.0 1.0 -0.5 0.1
Lupus 1.0 1.6 5.0 -1.1 -2.2 1.1 0.0 -1.8 0.0 -0.4
Neuroticism (2016) 0.5 0.7 2.4 1.1 1.6 0.2 0.0 -0.8 -0.4 0.5
Primary Biliary Cirrhosis 0.2 0.3 1.2 -0.6 -0.4 -0.2 0.0 1.1 -0.0 -0.2
Rheumatoid Arthritis 0.1 0.1 0.5 0.2 0.2 -0.2 0.0 0.3 -0.7 -0.4
Schizophrenia (2014) 0.8 1.8 6.3 1.7 1.5 -2.5 0.0 -1.0 -0.2 0.3
Triglycerides 0.5 0.9 1.7 -0.6 -1.0 -0.7 0.0 -1.3 1.2 -1.1
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.6 0.5 0.8 -1.3 0.0 -1.0 0.4 -0.5
Ulcerative Colitis 1.5 2.2 8.1 0.0 -2.9 0.7 0.0 -2.1 1.3 -0.6
Blood Eosinophil Count 0.8 5.8 20.8 0.6 1.5 -0.4 0.0 3.1 -4.6 2.7
Blood Platelet Count 6.8 78.4 210.2 14.5 9.6 -11.0 0.0 -7.9 5.5 -5.7
Blood Red Count 0.8 7.5 28.5 0.9 -2.8 -1.9 0.0 -3.0 5.3 -1.9
Blood White Count 1.3 9.6 47.5 0.2 1.4 -3.3 0.0 0.8 -6.9 2.5
Heel T-Score 0.7 5.4 17.8 -4.2 -3.6 1.6 0.0 0.4 1.3 -1.5
BMI 1.3 7.8 20.0 4.5 4.0 -3.3 0.0 -2.4 -0.4 1.4
Height 1.5 29.0 61.8 6.9 7.5 -7.9 0.0 -5.7 0.7 2.0
Waist Hip Ratio (WHR) 0.4 1.7 4.5 2.1 -0.1 -1.1 0.0 -1.6 0.9 -1.6
Systolic Blood Pressure 1.1 5.5 13.8 -3.1 -3.0 3.7 0.0 1.8 -1.6 0.7
Smoking Status 3.8 9.0 21.5 4.6 3.9 -4.2 0.0 -3.0 -0.2 0.4
Allergy or Eczema 0.3 0.8 3.2 1.4 1.8 -0.4 0.0 -0.2 -0.3 -0.3
Cardiovascular Disease 0.7 2.4 5.6 0.0 1.3 2.4 0.0 2.0 -1.5 1.8
Hypothyroidism (self reported) 0.7 1.6 3.7 1.3 1.9 0.7 0.0 -1.3 0.3 1.8
Respiratory disease 1.3 2.9 9.0 2.5 1.3 -3.0 0.0 -1.9 0.3 -0.5
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.3 1.8 1.4 -1.7 0.0 -0.8 -1.0 0.8
Lung FEV1/FVC ratio 0.0 0.2 0.7 -0.2 0.4 0.3 0.0 0.7 0.4 0.8
Lung FVC 0.6 3.1 9.9 -2.2 -2.2 0.8 0.0 -1.2 3.1 0.2
Neuroticism 2.2 5.3 15.6 3.7 4.0 -2.1 0.0 -1.7 -0.6 0.3
Chronotype (morning person) 0.7 1.5 3.3 -0.8 -1.8 1.6 0.0 -1.6 1.1 -0.4
Hair Pigment 0.1 1.5 3.8 1.9 1.4 -1.2 0.0 -1.3 0.4 -1.3
Tanning 0.0 0.5 1.8 1.2 1.3 0.2 0.0 -0.6 -0.0 0.3
Hand grip strength (left) 0.4 1.1 5.7 0.1 0.4 -2.4 0.0 -1.2 0.2 -0.3
Number of treatments/medications taken 2.7 4.9 14.1 3.8 3.1 -2.5 0.0 -1.6 -1.3 0.3
Average weekly spirits intake 1.2 1.5 3.7 1.9 1.0 -1.5 0.0 -1.1 1.0 -1.3
Sensitivity / hurt feelings 1.2 2.0 7.4 2.0 2.7 -1.1 0.0 -0.5 -1.0 -0.2
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.8 0.9 1.9 -0.9 0.0 -0.4 -1.1 -0.6
Hearing difficulty/problems: Yes 0.1 0.2 1.0 0.5 0.0 -0.4 0.0 -0.3 -1.0 0.1
Relative age of first facial hair 0.5 1.0 3.9 -0.5 -2.0 1.4 0.0 -0.0 -0.2 -1.0
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 3.4 1.8 1.8 -1.2 0.0 -0.2 0.5 -0.6
Ever used hormone-replacement therapy (HRT) 2.0 2.6 7.3 2.5 2.7 -1.5 0.0 -0.7 -1.2 0.1
Ever had hysterectomy (womb removed) 1.3 1.5 3.6 0.6 -0.5 -1.9 0.0 -1.9 1.2 -1.1
Systolic blood pressure, automated reading 0.4 1.1 3.3 -0.8 -0.6 1.8 0.0 0.3 -1.3 1.1
Eye problems/disorders: Diabetes related eye disease 2.5 2.7 10.3 2.1 3.2 -0.8 0.0 0.5 0.3 1.8
Angina 1.5 1.9 5.2 2.0 2.3 0.0 0.0 0.1 -0.5 2.0
Medication for hormone replacement therapy 2.3 2.6 5.6 2.2 2.4 -2.0 0.0 -0.5 -1.3 -1.2
Vitamin and mineral supplements 0.4 0.5 1.1 -1.0 -0.7 0.5 0.0 0.1 -0.9 1.0
Supplements: Zinc 0.4 0.5 1.6 1.2 1.0 -0.6 0.0 -0.6 -0.1 0.0
Medication: Co-codamol 0.6 0.7 1.8 -0.2 1.2 0.4 0.0 0.3 -1.3 1.3
Medication: Metformin 1.5 2.2 5.7 2.4 0.5 -2.0 0.0 -2.2 -0.1 0.4
Diabetes (father) 0.7 0.9 2.6 0.8 1.6 -1.6 0.0 0.4 -0.4 0.5
Diabetes (mother) 0.2 0.3 0.8 -0.9 -0.6 0.3 0.0 0.5 -0.2 0.6
Severe depression (siblings) 0.5 0.5 1.8 0.1 0.2 0.2 0.0 0.9 -1.3 1.0
Pack years adult smoking proportion 1.2 1.8 4.4 1.5 0.5 -2.1 0.0 -2.1 1.0 -0.7
Impedance of leg (right) 1.0 4.9 15.7 -2.7 -1.6 4.0 0.0 2.9 -0.5 -0.5
Leg fat-free mass (left) 2.4 12.6 36.1 4.3 3.3 -6.0 0.0 -4.3 -0.0 2.1
Trunk fat percentage 1.9 7.8 24.9 5.0 4.2 -2.2 0.0 -2.1 -0.5 1.4
Hand grip strength (right) 0.8 2.1 9.4 0.7 1.1 -3.1 0.0 -1.3 1.3 0.2
Townsend deprivation index at recruitment 1.4 1.9 5.4 1.8 0.3 -1.7 0.0 -2.3 -1.3 -0.3
Current tobacco smoking 1.9 3.2 8.2 2.4 1.8 -2.9 0.0 -2.2 -0.2 -0.1
Average weekly fortified wine intake 0.6 0.7 2.2 -0.7 -0.4 -0.2 0.0 1.3 -1.5 0.3
Maternal smoking around birth 0.5 0.7 1.9 1.4 1.0 -0.0 0.0 -1.2 0.9 -0.1
Fed-up feelings 2.2 3.9 9.2 3.0 2.3 -2.3 0.0 -2.2 0.6 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.1 6.0 2.5 2.1 -2.1 0.0 -2.2 -0.6 -1.3
Relative age voice broke 1.2 1.8 5.2 -1.2 -1.7 2.3 0.0 1.3 -0.4 -1.2
Taking other prescription medications 3.7 5.8 17.1 4.1 2.6 -2.5 0.0 -3.1 -0.1 -0.7
Age when periods started (menarche) 1.7 4.1 11.7 -2.5 -2.4 3.4 0.0 2.2 0.1 0.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.7 0.4 -0.3 -1.3 0.0 -0.6 -1.0 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.5 4.3 -1.8 -2.1 0.9 0.0 -1.2 0.6 -0.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 0.0 -0.6 -0.2 0.0 -0.9 -0.8 1.1
Qualifications: CSEs or equivalent 0.1 0.1 0.5 -0.2 0.4 -0.2 0.0 -0.7 -0.0 0.5
Serious illness, injury or assault to yourself 0.4 0.5 2.0 -0.5 -0.4 -0.2 0.0 0.9 -0.1 1.4
High blood pressure 0.6 1.6 4.3 0.1 0.3 1.7 0.0 1.4 -2.1 1.4
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.0 0.8 0.5 -0.0 0.0 -1.0 0.4 -1.0
Multivitamins +/- minerals 1.8 2.3 5.4 2.3 1.0 -2.2 0.0 -1.4 1.1 -1.2
Stomach or abdominal pain in last month 0.5 0.6 2.9 0.2 0.9 -0.4 0.0 0.1 -0.5 1.7
Supplements: Glucosamine 0.2 0.3 0.9 0.3 0.7 0.3 0.0 0.6 0.9 -0.3
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.0 1.4 1.3 -0.7 0.0 0.8 -1.3 -0.1
Medication: Atenolol 0.6 0.7 2.2 0.8 1.5 -0.5 0.0 -0.0 -1.2 0.6
Medication: Levothyroxine sodium 0.5 0.9 2.3 0.9 1.4 -0.3 0.0 -1.5 -0.9 0.8
Sitting height 1.4 10.1 38.6 3.0 2.8 -6.2 0.0 -3.7 0.7 1.1
Chronic bronchitis/emphysema (father) 1.0 1.1 5.1 0.4 2.3 -0.8 0.0 1.0 -0.8 0.5
High blood pressure (mother) 1.3 1.8 7.0 -1.0 -0.1 1.3 0.0 2.6 -1.1 1.2
Body mass index (BMI) 1.9 8.1 19.6 4.4 3.3 -3.6 0.0 -3.1 -0.3 1.9
Impedance of leg (left) 0.6 2.8 9.4 -1.6 -1.2 3.1 0.0 2.0 0.4 -1.5
Leg predicted mass (left) 2.4 12.7 36.1 4.3 3.3 -6.0 0.0 -4.3 0.1 2.1
Trunk fat mass 2.8 12.0 32.1 5.7 4.6 -3.8 0.0 -3.4 -0.3 1.8
Waist circumference 4.0 14.6 38.2 6.2 4.1 -5.2 0.0 -4.4 -0.2 1.2
Number of incorrect matches in round 1.9 3.2 6.4 2.1 2.4 -2.5 0.0 -2.1 -1.1 -0.9
Past tobacco smoking 2.0 3.7 10.7 -3.0 -3.3 1.4 0.0 1.3 1.5 -0.7
Alcohol usually taken with meals 2.3 3.6 10.3 -3.1 -3.2 1.6 0.0 0.8 -0.2 1.5
Nervous feelings 0.6 1.0 3.4 1.0 1.9 -1.4 0.0 -0.4 -0.9 0.1
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 6.5 1.8 2.5 -1.1 0.0 -1.5 -0.2 -0.1
Hearing difficulty/problems with background noise 0.2 0.3 1.4 0.2 0.2 -0.4 0.0 0.2 -1.2 0.7
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 -0.1 -0.2 -0.3 0.0 -0.0 -0.9 -1.0
Had menopause 1.2 1.4 3.7 0.8 1.9 -0.9 0.0 1.7 -1.3 0.3
Had other major operations 0.3 0.3 1.5 0.3 0.4 -0.5 0.0 0.4 -0.4 1.2
Forced vital capacity (FVC) 0.3 1.0 3.4 -0.3 0.2 -0.8 0.0 -1.9 1.5 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 6.6 -2.5 -2.6 0.4 0.0 -0.6 0.6 -0.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.8 0.5 1.1 -0.8 0.0 -0.0 -2.0 0.1
Qualifications: None of the above 4.2 8.9 17.8 4.2 1.9 -3.5 0.0 -4.0 2.5 -2.5
Financial difficulties in last 2 years 1.5 2.0 8.6 1.2 1.0 -1.0 0.0 0.9 -2.9 1.0
Mouth/teeth dental problems 0.8 1.3 4.4 -0.9 -1.5 0.1 0.0 -0.4 1.2 -2.1
Heart attack 2.7 3.5 10.2 3.2 1.9 -2.5 0.0 -1.8 -1.2 0.2
Allergy 0.9 2.0 5.2 -1.8 -0.5 1.8 0.0 2.3 -0.9 1.1
Pain all over the body in last month 1.2 1.3 5.6 1.4 2.4 -0.9 0.0 -0.1 -0.5 -0.3
Diabetes (self-reported) 0.6 0.9 2.0 1.4 1.3 -1.3 0.0 -0.3 0.1 0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.5 -0.5 -1.2 0.2 0.0 0.5 0.5 -0.8
Medication: Ramipril 0.3 0.4 2.8 0.4 -0.3 -0.1 0.0 -0.0 -1.7 -0.1
Medication: Simvastatin 2.3 3.4 10.5 3.2 2.1 -2.4 0.0 -1.7 0.5 -0.3
Fluid intelligence score 4.1 8.5 21.8 -4.2 -2.7 3.1 0.0 4.7 -1.1 1.6
Illnesses of siblings 1.4 1.9 7.3 -1.1 -1.2 0.2 0.0 -1.0 1.5 -2.7
Neuroticism score 1.6 3.4 13.6 2.7 3.7 -1.1 0.0 -1.2 -0.6 0.2
Weight 3.1 15.4 31.0 5.6 4.4 -5.5 0.0 -4.7 0.1 2.2
Impedance of arm (right) 1.1 5.2 19.7 -1.8 -0.2 4.4 0.0 3.3 -1.4 -0.4
Arm fat percentage (right) 1.7 6.5 17.6 4.2 3.8 -2.0 0.0 -2.2 -0.6 2.0
Trunk fat-free mass 2.5 14.3 46.8 3.8 2.8 -6.8 0.0 -5.2 0.6 1.9
Hip circumference 2.0 8.5 17.9 4.2 3.4 -3.8 0.0 -2.9 -1.2 2.3
Time employed in main current job 0.5 0.6 1.6 0.1 1.1 -1.3 0.0 0.3 0.5 1.0
Alcohol intake versus 10 years previously 0.8 1.2 2.7 -0.5 -1.1 -0.2 0.0 -1.3 1.6 -1.5
Father’s age at death 0.1 0.1 0.5 0.1 0.5 0.2 0.0 -0.1 -0.2 0.7
Worrier / anxious feelings 0.6 1.2 3.1 -0.2 1.3 0.8 0.0 0.7 -1.8 1.5
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 4.8 2.2 2.1 -2.0 0.0 -0.5 0.2 0.0
Falls in the last year 1.7 2.3 6.5 2.5 2.2 -2.1 0.0 -0.6 -0.4 0.3
Hair/balding pattern: Pattern 3 0.8 1.2 3.0 1.7 1.7 -0.7 0.0 -0.7 1.0 -0.6
Number of live births 0.6 0.9 3.8 0.1 -1.1 -1.9 0.0 -1.1 0.0 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.4 -0.9 0.0 0.2 0.0 -0.7 1.2 1.1
Pulse rate 2.5 4.2 13.3 2.5 2.5 -3.6 0.0 -1.3 -1.0 0.7
Happiness 1.0 1.2 2.4 0.7 1.3 -1.4 0.0 0.4 -1.5 1.3
Noisy workplace 0.6 0.7 2.9 0.5 -0.2 -0.1 0.0 -1.7 1.2 -0.6
Qualifications: A levels/AS levels or equivalent 3.3 7.3 17.6 -4.2 -3.1 3.1 0.0 3.1 -1.7 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.3 0.5 0.5 -0.3 0.0 -0.4 -0.5 0.3
Mouth/teeth dental problems: Dentures 0.9 1.5 2.7 1.6 1.6 -1.0 0.0 -1.6 1.0 -0.5
Asthma 1.6 3.2 10.9 2.2 0.5 -3.3 0.0 -2.4 -0.1 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.6 0.7 1.1 -0.7 0.0 0.7 -1.6 0.7
Medication: Cholesterol lowering 1.3 2.1 5.6 2.4 0.7 -2.4 0.0 -1.5 -0.9 -0.3
Depression (self-reported) 0.6 0.7 2.8 1.3 1.7 0.4 0.0 0.1 -0.4 -0.1
Medication: Lansoprazole 0.1 0.1 0.3 -0.4 -0.2 -0.2 0.0 0.3 -0.2 0.5
Prospective memory result 3.3 4.1 7.6 2.8 1.7 -1.9 0.0 -2.7 2.0 -1.8
Lung cancer (father) 1.4 1.7 4.3 0.8 0.4 -1.4 0.0 -2.0 0.8 -2.1
Illnesses of mother 0.5 0.6 2.0 0.4 1.4 0.1 0.0 -0.9 1.0 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 4.7 -2.2 -0.8 0.9 0.0 0.2 0.6 1.3
Pulse wave Arterial Stiffness index 2.1 2.4 5.4 1.9 1.6 -2.0 0.0 -0.1 -1.2 2.3
Impedance of arm (left) 1.1 5.0 18.7 -1.6 0.0 4.3 0.0 3.5 -1.1 -0.4
Arm fat mass (right) 2.5 10.4 23.7 4.9 4.4 -3.7 0.0 -3.1 -0.4 2.6
Trunk predicted mass 2.6 14.7 48.0 3.9 2.9 -6.9 0.0 -5.2 0.6 1.9
Standing height 0.8 8.3 23.2 3.1 2.8 -4.8 0.0 -4.0 0.9 0.7
Length of working week for main job 1.6 1.8 3.7 -1.9 -1.8 0.2 0.0 1.9 -1.3 -0.5
Exposure to tobacco smoke at home 0.2 0.3 0.6 0.4 0.7 -0.4 0.0 -0.6 -0.3 0.7
Breastfed as a baby 1.7 2.2 6.8 0.1 1.9 -0.3 0.0 2.6 -1.1 1.9
Tense / ‘highly strung’ 0.6 0.9 4.5 0.4 2.1 0.6 0.0 -0.7 0.2 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.9 0.1 1.2 0.1 0.0 0.8 -1.6 1.7
Hair/balding pattern: Pattern 4 0.9 2.1 4.0 -2.0 -0.9 1.1 0.0 1.8 -1.6 1.8
Birth weight of first child 0.3 0.5 2.2 -0.3 -0.3 -0.3 0.0 -0.2 1.5 0.9
Peak expiratory flow (PEF) 0.2 0.6 2.6 -0.0 1.6 0.5 0.0 0.6 0.4 0.7
Pulse wave reflection index 0.2 0.2 1.2 0.4 -0.3 -0.0 0.0 -0.1 1.1 -0.5
Ever highly irritable/argumentative for 2 days 1.5 1.8 4.2 2.1 2.0 -1.4 0.0 -1.3 0.3 0.8
Loud music exposure frequency 0.9 0.9 4.0 0.6 -0.3 -0.9 0.0 -2.0 0.3 -1.1
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 7.6 -1.4 -0.8 2.7 0.0 1.5 -0.7 0.9
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 3.5 1.9 1.4 -0.8 0.0 -0.1 -0.5 0.5
Blood clot in the leg (DVT) 2.1 2.7 6.3 2.4 1.2 -2.5 0.0 -1.8 1.3 0.4
Medication: Paracetamol 0.8 1.3 3.3 -0.5 0.4 0.6 0.0 1.3 -1.8 1.7
Headache pain in last month 0.7 1.3 3.4 1.2 1.0 -1.9 0.0 -0.6 0.7 1.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 5.6 -2.4 -1.4 1.3 0.0 0.5 1.3 -0.4
Glaucoma (self-reported) 0.3 0.3 1.0 0.1 -0.4 0.6 0.0 -0.7 0.5 -1.0
Gout (self-reported) 0.3 0.4 1.4 0.0 -0.2 1.0 0.0 0.6 -0.0 -1.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 4.1 1.1 2.0 0.3 0.0 -1.3 -0.4 1.3
Medication: Amlodipine 1.6 2.3 5.1 -1.2 0.6 2.2 0.0 1.8 -1.5 1.8
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.5 0.7 0.4 -0.1 0.0 -0.1 -0.2 -0.7
Birth weight 0.3 0.7 1.9 1.4 0.9 0.1 0.0 -0.6 1.3 -0.2
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.8 -0.4 -1.0 0.9 0.0 -1.2 0.9 -1.3
High blood pressure (siblings) 0.8 1.2 3.5 1.0 1.3 -0.3 0.0 0.8 -1.1 1.9
Forced vital capacity (FVC), Best measure 0.3 1.0 3.6 -1.9 -0.9 0.4 0.0 -0.5 0.4 1.5
Body fat percentage 1.9 7.4 22.6 4.8 4.0 -2.3 0.0 -2.2 -0.5 1.7
Leg fat percentage (right) 1.4 5.1 12.6 3.6 3.1 -2.1 0.0 -1.7 -0.9 2.4
Arm fat-free mass (right) 3.0 15.4 46.3 4.6 3.3 -6.8 0.0 -5.1 1.1 1.5
Exposure to tobacco smoke outside home 2.1 2.8 10.4 2.0 3.2 0.7 0.0 0.7 0.2 2.1
Comparative body size at age 10 1.0 2.9 8.5 2.2 2.3 -2.9 0.0 -0.3 -1.2 -0.1
Number of full brothers 0.9 1.2 3.7 -1.6 -1.9 1.3 0.0 0.3 -0.3 -0.1
Worry too long after embarrassment 0.3 0.6 2.7 0.5 1.6 -0.7 0.0 0.1 -0.5 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.6 1.9 1.4 -0.6 0.0 -0.3 -0.1 -1.0
Wheeze or whistling in the chest in last year 2.6 4.6 10.7 3.3 3.2 -1.8 0.0 -2.7 0.7 -0.5
Number of children fathered 0.1 0.1 0.9 -0.0 -0.0 0.2 0.0 -0.0 -0.2 0.9
Reason for reducing amount of alcohol drunk: Health precaution 3.9 4.5 12.1 1.7 -0.4 -1.2 0.0 -3.5 2.1 -3.2
Age at first live birth 0.5 0.9 5.0 0.3 0.4 0.6 0.0 -0.9 0.6 -2.2
Pulse wave peak to peak time 1.6 1.9 5.3 -1.7 -1.4 1.5 0.0 -0.1 1.1 -2.3
Health satisfaction 1.9 2.5 7.2 1.8 1.7 -1.6 0.0 -2.7 1.0 -0.7
Shortness of breath walking on level ground 3.1 3.7 17.1 2.6 4.1 -1.1 0.0 -0.3 0.9 -0.0
Qualifications: College or University degree 1.8 5.5 11.8 -3.0 -0.7 1.8 0.0 3.4 -2.5 2.8
Eye problems/disorders: None of the above 0.1 0.1 0.1 -0.3 -0.3 -0.2 0.0 -0.4 -0.2 0.2
Mouth/teeth dental problems: Loose teeth 1.0 1.2 4.6 0.0 0.3 2.2 0.0 0.5 -1.0 1.5
Emphysema/chronic bronchitis 1.4 1.6 4.6 1.6 0.3 -1.4 0.0 -2.1 0.7 -1.1
Medication for pain relief, constipation, heartburn 0.8 1.4 4.3 -0.7 -1.2 0.9 0.0 -0.8 1.4 -2.1
Neck or shoulder pain in last month 0.4 0.5 1.8 0.0 1.3 0.6 0.0 0.4 0.9 0.6
Medication: Blood pressure 0.6 1.1 3.8 1.9 1.1 -0.7 0.0 -0.1 -1.6 -0.2
Angina (self-reported) 1.4 1.9 5.0 2.0 2.2 -0.3 0.0 -0.1 -0.6 2.0
Migraine (self-reported) 0.4 0.5 1.5 -0.1 -1.0 0.5 0.0 -0.2 1.2 -1.0
Medication: Ibuprofen 1.6 1.9 6.7 0.4 1.5 -1.4 0.0 1.0 -2.6 1.1
Medication: Allopurinol 0.3 0.4 1.7 0.1 -0.1 0.9 0.0 0.1 -0.6 -1.3
Medication: Omeprazole 1.4 1.6 6.9 1.1 2.6 -0.6 0.0 1.1 -0.4 1.2
Medication: Seretide 50 evohaler 0.6 0.7 1.8 -0.2 -1.3 -0.8 0.0 -0.9 -1.4 0.4
Mean time to correctly identify matches 0.3 0.7 2.7 -0.4 -0.6 1.6 0.0 1.0 -0.5 0.1
Heart disease (mother) 0.8 1.0 3.2 0.3 -0.2 -1.7 0.0 -0.8 -0.5 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.6 0.1 0.2 0.4 0.0 0.2 -1.2 1.1
Whole body fat mass 2.8 11.9 30.6 5.5 4.5 -4.0 0.0 -3.4 -0.4 2.1
Leg fat mass (right) 2.8 10.9 25.0 5.0 4.2 -4.0 0.0 -3.2 -0.5 2.6
Arm predicted mass (right) 2.7 13.7 41.4 4.3 3.1 -6.4 0.0 -4.8 1.0 1.7
Pulse rate, automated reading 1.5 4.7 11.1 2.1 2.2 -2.5 0.0 -1.4 -2.1 3.3
Alcohol intake frequency. 0.5 1.2 3.0 -1.5 -1.7 0.1 0.0 1.5 -0.9 0.0
Comparative height size at age 10 1.6 8.8 28.3 3.3 4.4 -5.3 0.0 -1.7 -0.5 -0.1
Number of full sisters 1.0 1.2 4.0 -1.0 -2.0 1.4 0.0 0.8 0.7 -0.2
Suffer from ‘nerves’ 1.6 2.6 7.9 2.1 2.8 -1.5 0.0 -1.8 0.1 0.3
Overall health rating 2.2 4.8 15.6 4.0 2.5 -2.5 0.0 -2.4 -0.2 -0.1
Chest pain or discomfort 0.9 1.3 4.8 1.4 0.5 -1.4 0.0 -2.2 0.2 0.2
Had major operations 0.4 0.5 1.9 0.2 -0.1 -1.4 0.0 0.9 0.1 0.7
Age at last live birth 1.4 2.0 5.9 0.1 -1.4 -1.9 0.0 -1.6 -0.2 -2.4
Family relationship satisfaction 1.2 1.5 4.8 1.2 2.2 -0.9 0.0 0.7 -0.8 1.5
Leg pain on walking 0.2 0.2 0.4 -0.4 -0.4 -0.5 0.0 -0.6 -0.3 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 4.6 -1.4 -2.1 0.1 0.0 0.2 0.0 1.0
Commuting to job workplace: Car/motor vehicle 2.0 2.2 5.3 2.3 1.8 -1.1 0.0 -1.5 1.9 -0.5
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 5.8 -2.4 -1.4 1.1 0.0 0.5 0.1 0.8
Medication: Aspirin 2.6 3.5 8.7 2.8 1.6 -2.9 0.0 -2.1 -0.5 0.5
Supplements: Vitamin C 0.3 0.4 0.7 -0.8 -0.8 0.6 0.0 0.3 0.5 -0.9
Knee pain experienced in last month 1.0 1.6 5.1 2.3 1.4 -1.7 0.0 -0.9 0.1 0.7
Hypertension (Self-reported) 0.6 1.6 4.4 0.5 0.9 1.5 0.0 1.6 -2.1 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 6.4 1.6 2.5 -1.1 0.0 0.4 0.4 -0.3
Illnesses of father: Heart disease 1.1 1.5 3.6 0.8 1.9 -1.4 0.0 0.0 -1.6 1.5
Illnesses of siblings: Diabetes 0.2 0.3 0.7 -0.2 -0.8 0.8 0.0 0.7 0.3 0.1
Smoking status: Previous 1.5 2.2 7.1 2.5 2.7 -0.9 0.0 -1.0 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 8.9 2.5 1.4 -2.6 0.0 -3.0 1.1 -1.3
Whole body fat-free mass 2.7 15.2 46.5 4.3 3.2 -6.8 0.0 -5.2 0.6 1.8
Leg fat-free mass (right) 2.7 14.3 41.2 4.7 3.4 -6.4 0.0 -4.7 0.5 1.5
Arm fat percentage (left) 1.8 7.1 19.2 4.4 4.2 -2.1 0.0 -1.9 -0.6 2.2
Average weekly red wine intake 0.2 0.3 1.8 0.6 1.3 -0.3 0.0 0.0 -0.4 -0.2
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.8 1.7 0.9 -1.7 0.0 -1.5 -0.0 -0.6
Mood swings 5.3 9.6 27.9 5.3 5.1 -2.5 0.0 -2.1 1.2 -1.0
Loneliness, isolation 2.7 3.8 13.1 3.1 3.6 -1.6 0.0 -1.1 -0.1 -0.3
Long-standing illness, disability or infirmity 2.6 4.0 11.0 3.3 1.0 -3.2 0.0 -2.3 -0.0 -0.8
Ever had bowel cancer screening 0.2 0.2 0.6 -0.2 0.4 0.6 0.0 0.7 -0.3 0.5
Diabetes diagnosed by doctor 1.1 1.8 5.6 2.4 1.7 -1.6 0.0 -1.2 0.3 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 3.3 0.4 0.5 -1.8 0.0 -1.2 -1.3 1.1
Friendships satisfaction 0.4 0.5 1.3 0.7 1.1 -1.1 0.0 -0.6 -0.3 0.3
Qualifications: nursing, teaching 1.1 1.7 6.1 -1.5 -0.6 2.5 0.0 1.7 -0.5 0.6
Commuting to job workplace: Walk 2.0 2.2 7.3 -1.9 -1.7 2.7 0.0 0.8 -0.5 -0.9
Eye problems/disorders: Cataract 0.4 0.4 1.1 1.0 0.6 -0.7 0.0 -0.6 0.4 -0.6
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 4.2 -1.9 -1.4 2.0 0.0 1.9 -1.3 1.0
Medication for cholesterol 0.4 0.7 3.0 -1.0 -1.7 0.6 0.0 0.2 0.6 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.3 1.4 1.5 -1.1 0.0 -0.1 -0.1 0.1
Back pain experienced in last month 2.0 2.9 5.6 2.4 1.7 -1.7 0.0 -1.8 2.2 -0.8
Mineral and other dietary supplements 1.6 2.2 5.9 -2.1 -0.9 0.8 0.0 1.6 -2.4 1.1
Breast cancer (self-reported) 0.4 0.5 1.5 -0.0 -1.2 -0.3 0.0 0.0 0.6 1.2
Asthma (self-reported) 1.9 3.8 12.4 2.5 0.7 -3.5 0.0 -2.6 0.1 -1.0
Osteoporosis (self-reported) 0.9 1.1 2.9 0.3 -1.7 0.1 0.0 -1.5 0.5 -1.5
Osteoarthritis (self-reported) 0.6 0.8 3.2 1.8 0.9 -0.9 0.0 -0.6 0.7 -0.4
Medication: Aspirin 2.3 3.0 7.2 2.7 1.5 -2.7 0.0 -2.0 -0.4 0.2
Medication: Gliclazide 0.7 0.8 2.6 1.3 0.2 -1.2 0.0 -1.6 -0.1 -0.2
Illnesses of father: None of the above (group 1) 1.3 1.6 6.2 0.0 -1.3 0.2 0.0 -0.8 1.6 -2.5
Smoking status: Current 1.7 2.6 7.1 2.1 1.8 -2.7 0.0 -1.9 -0.4 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 4.4 -1.8 0.2 2.1 0.0 1.1 1.4 1.7
Whole body water mass 2.7 15.3 47.1 4.3 3.2 -6.9 0.0 -5.2 0.7 1.9
Leg predicted mass (right) 2.7 14.2 40.9 4.7 3.3 -6.4 0.0 -4.7 0.5 1.5
Arm fat mass (left) 2.7 11.3 25.6 5.1 4.5 -4.0 0.0 -3.2 -0.3 2.5
Number of self-reported non-cancer illnesses 2.0 3.4 11.2 3.3 2.9 -1.1 0.0 -0.0 -1.3 1.1
Average weekly champagne plus white wine intake 1.7 2.3 7.2 -2.7 -2.4 1.1 0.0 0.7 -0.4 1.3
Miserableness 0.7 1.3 3.7 1.9 1.7 -0.3 0.0 -0.6 -0.6 1.1
Guilty feelings 1.9 2.9 8.0 2.8 2.1 -1.1 0.0 -2.3 0.6 -0.7
Wears glasses or contact lenses 1.2 1.3 4.0 1.5 1.1 -2.0 0.0 -0.7 1.0 -0.6
Ever taken oral contraceptive pill 1.1 1.2 5.0 1.3 1.1 -0.0 0.0 -0.8 2.2 0.0
Hearing aid user 1.5 1.7 5.6 1.5 1.7 -2.4 0.0 0.1 -0.6 0.7
Mother’s age at death 0.4 0.6 2.6 -0.2 0.4 -1.6 0.0 -0.4 -1.0 -0.3
Financial situation satisfaction 0.9 1.1 3.1 1.0 0.8 -1.8 0.0 -1.1 -0.9 0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.1 0.3 0.4 0.0 -0.2 0.6 -0.3
Commuting to job workplace: Public transport 1.6 1.9 6.2 -1.8 -1.5 2.5 0.0 0.4 -1.1 0.3
Eye problems/disorders: Glaucoma 0.6 0.7 2.0 -0.5 -1.4 0.2 0.0 -1.0 0.9 -1.1
Medication: Blood pressure 0.2 0.4 1.1 0.0 0.8 1.1 0.0 0.8 -0.7 0.2
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.6 1.2 1.1 -1.1 0.0 0.3 -1.3 0.1
Supplements: Fish oil (including cod liver oil) 2.4 3.2 11.6 2.2 0.4 -0.8 0.0 -1.6 3.4 -1.6
High cholesterol (Self-reported) 0.9 1.7 5.8 2.1 2.4 -0.9 0.0 -0.3 0.3 0.6
Medication: Bendroflumethiazide 1.8 2.7 9.7 -0.8 0.3 0.7 0.0 3.1 -2.7 0.9
Medication: Paracetamol 0.7 1.1 3.5 -1.0 -0.2 0.2 0.0 1.2 -1.9 1.3
Medication: Lisinopril 0.3 0.4 1.1 1.0 -0.2 -0.2 0.0 -1.0 0.5 -0.8
Medication: Atorvastatin 0.3 0.4 2.0 0.2 0.5 -0.4 0.0 0.7 -1.4 0.1
Illnesses of father: High blood pressure 0.9 1.1 3.0 -1.0 -1.0 1.7 0.0 1.3 -0.2 1.2
Alcohol drinker status: Never 1.0 1.2 4.2 -1.5 -2.0 0.3 0.0 0.5 1.0 -0.8
Ever smoked 2.8 4.9 13.8 3.6 3.7 -1.7 0.0 -1.4 -1.3 0.7
Basal metabolic rate 2.7 15.2 43.3 4.6 3.4 -6.6 0.0 -5.1 0.5 2.0
Leg fat percentage (left) 1.6 5.9 16.8 4.1 3.1 -2.6 0.0 -2.2 -0.2 1.9
Arm fat-free mass (left) 3.0 15.2 45.3 4.4 3.0 -6.7 0.0 -5.4 1.0 1.6
Number of operations (self-reported) 0.4 0.6 1.8 -0.4 -0.5 0.2 0.0 1.4 -0.5 1.2
Average weekly beer plus cider intake 1.3 1.8 3.0 1.7 1.7 -0.7 0.0 -1.7 1.2 -1.5
Irritability 1.4 2.4 6.2 1.5 1.6 0.7 0.0 -1.2 2.5 -1.8
Risk taking 0.9 1.4 3.8 1.7 0.5 -0.5 0.0 -1.6 -0.3 -1.9
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.8 1.5 0.9 -1.9 0.0 -1.5 0.4 -0.2
Fractured/broken bones in last 5 years 0.4 0.5 1.1 -0.2 1.1 1.1 0.0 1.0 -0.0 -0.1
Age started oral contraceptive pill 0.8 1.0 4.1 -1.5 -2.0 0.7 0.0 -0.2 0.1 0.0
Diastolic blood pressure, automated reading 0.5 1.6 4.0 -0.9 -0.9 2.0 0.0 1.0 -1.7 1.2
Ever depressed for a whole week 0.8 1.0 3.8 0.2 1.3 -0.5 0.0 0.3 -2.0 0.9
Unable to work because of sickness or disability 0.8 1.0 3.7 1.7 1.9 0.2 0.0 0.4 0.0 -0.3
Commuting to job workplace: Cycle 1.2 1.5 5.1 0.9 2.3 -0.7 0.0 0.9 -1.7 0.0
Myopia 1.3 1.9 7.0 2.7 1.8 0.3 0.0 -1.4 0.8 -0.8
Vascular/heart problems diagnosed by doctor 0.4 1.2 4.1 -0.9 -0.5 -1.1 0.0 -0.6 2.0 -1.3
Cholesterol lowering medication 0.8 1.2 3.3 1.4 1.8 -0.8 0.0 -1.3 0.6 0.7
Medication: Omeprazole (e.g. Zanprol) 2.4 2.9 10.8 1.0 3.3 -0.4 0.0 1.5 -1.1 2.2
Pain experienced in last month 1.3 2.2 6.2 -2.1 -2.5 1.7 0.0 0.6 -0.9 -1.0
Supplements: Calcium 0.5 0.6 1.9 0.8 0.8 -0.0 0.0 -1.4 0.6 -0.8
Basal cell carcinoma (self-reported) 1.3 1.5 3.4 1.6 -0.3 -0.9 0.0 -1.7 0.7 -1.8
Heart attack/myocardial infarction (self-reported) 2.9 3.7 10.9 3.3 1.8 -2.7 0.0 -1.6 -1.4 0.1
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 6.1 2.4 1.4 -2.5 0.0 -1.7 1.4 0.7
Heart disease (siblings) 0.8 1.0 4.5 -0.4 0.2 0.8 0.0 0.4 -1.2 2.1
Alcohol drinker status: Previous 0.5 0.6 2.2 0.3 0.3 -1.5 0.0 -0.5 -0.2 1.1
Pack years of smoking 1.4 2.0 5.1 1.6 0.7 -2.3 0.0 -2.0 1.1 -0.6
Impedance of whole body 0.9 4.8 19.3 -1.6 -0.4 4.4 0.0 3.1 -0.4 -1.1
Leg fat mass (left) 3.0 11.9 28.8 5.4 4.2 -4.3 0.0 -3.5 -0.1 2.3
Arm predicted mass (left) 2.7 14.0 40.5 4.2 2.9 -6.4 0.0 -5.2 1.1 1.6