TWAS hub - RHOF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.1003	0.0445	4.6e-03	0.055	NA	0.051	NA	0.077	7.0e-04	NA	1.0e-03	NA	6.4e-05
2	YFS	Blood	0.0928	0.0236	6.7e-14	0.065	0.054	0.065	0.066	0.066	2.0e-20	3.5e-17	2.2e-20	1.4e-20	8.5e-21
3	TCGA	Thyroid Carcinoma	0.0480	0.0210	1.2e-05	0.060	0.056	0.053	NA	0.056	1.8e-06	4.0e-06	6.0e-06	NA	3.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Coronary Artery Disease (CAD)	8.7	10.4	18.1	4.3	-0.9	3.5
Overall health rating	5.8	12.5	17.5	4.2	1.9	4.0
Long-standing illness, disability or infirmity	5.6	8.6	10.8	3.1	2.3	3.3
Number of self-reported non-cancer illnesses	5.6	9.6	16.6	4.1	-0.4	3.5
Financial difficulties in last 2 years	5.4	7.3	11.5	3.0	-1.3	3.4
Heart attack/myocardial infarction (self-reported)	5.3	6.8	13.2	2.6	0.4	3.6
Blood White Count	5.0	36.9	55.7	7.0	-2.3	7.5
Taking other prescription medications	5.0	7.7	9.0	3.0	2.5	2.8
Diverticular disease/diverticulitis (self-reported)	4.9	5.8	9.5	3.1	-0.1	2.8
Pulse wave Arterial Stiffness index	4.8	5.6	8.9	2.8	-0.0	3.0
Loneliness, isolation	4.7	6.4	12.1	3.5	1.2	2.4
Illnesses of siblings	4.6	6.5	10.2	-2.8	1.1	-3.2
Hearing aid user	4.4	4.9	8.1	2.9	-0.4	2.6
Number of treatments/medications taken	4.3	7.8	13.0	3.6	0.5	3.2
Pulse wave peak to peak time	4.3	5.1	8.2	-2.7	0.1	-2.9
HDL Cholesterol	4.2	7.1	13.4	2.7	-0.8	3.7
Heart attack	4.2	5.4	10.5	2.4	0.5	3.2
Supplements: Fish oil (including cod liver oil)	4.1	5.4	5.6	-2.3	2.4	-2.3
Medication: Omeprazole (e.g. Zanprol)	4.1	5.0	7.4	2.7	-2.1	1.8
Alcohol usually taken with meals	3.9	6.2	8.1	-2.8	-2.2	-2.4
Smoking Status	3.8	9.0	12.1	3.5	2.1	3.2
Medication: Ibuprofen	3.8	4.5	7.3	2.7	-1.2	2.2
Medication: Blood pressure	3.7	6.5	9.8	3.1	-0.0	3.1
Angina	3.6	4.7	7.7	2.5	-0.2	2.8
Waist circumference	3.6	13.0	18.3	4.3	2.1	4.0
Medication: Ramipril	3.6	4.6	7.4	2.5	0.0	2.7
Birth weight of first child	3.6	6.5	12.6	-3.5	-0.8	-2.5
High blood pressure (siblings)	3.6	5.3	8.1	2.8	-0.2	2.8
Comparative body size at age 10	3.6	9.8	16.7	4.1	0.4	3.5
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.3	7.2	-2.0	2.7	-1.3
Mean Putamen Volume	3.5	4.0	4.8	2.0	2.2	1.8
Trunk fat percentage	3.5	13.9	22.8	4.8	1.3	4.2
Ever unenthusiastic/disinterested for a whole week	3.5	4.2	8.5	2.9	-0.3	2.0
Happiness	3.5	4.3	7.1	2.7	-1.4	1.9
Body fat percentage	3.5	13.9	23.4	4.8	1.4	4.0
Angina (self-reported)	3.5	4.6	7.6	2.5	-0.2	2.8
Alcohol drinker status: Never	3.5	4.1	6.4	-2.5	0.6	-2.4
Basal cell carcinoma (self-reported)	3.5	4.2	10.8	1.1	3.3	0.8
Arm fat percentage (left)	3.4	13.4	24.5	5.0	0.9	3.8
Ever smoked	3.4	6.0	8.9	2.8	1.0	3.0
Blood Platelet Count	3.3	38.4	45.3	6.5	5.3	6.7
Ever used hormone-replacement therapy (HRT)	3.3	4.2	5.8	2.4	-1.2	2.3
Knee pain experienced in last month	3.3	5.1	6.8	2.6	1.6	2.4
Smoking status: Current	3.3	5.2	7.7	2.8	1.4	2.4
Trunk fat mass	3.2	13.6	21.5	4.6	1.7	4.0
Whole body fat mass	3.2	13.4	21.5	4.6	1.6	4.0
Leg fat mass (right)	3.2	12.2	20.9	4.6	1.3	3.7
Medication: Aspirin	3.2	4.2	7.2	2.3	0.3	2.7
Townsend deprivation index at recruitment	3.1	4.3	5.7	2.2	1.5	2.4
Current tobacco smoking	3.1	5.0	6.4	2.5	1.9	2.3
Leg fat percentage (right)	3.1	11.1	19.5	4.4	0.9	3.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	5.9	2.4	0.6	2.1
Medication: Aspirin	3.1	4.1	6.9	2.3	0.4	2.6
Bipolar Disorder or Schizophrenia	3.0	7.4	12.5	3.5	-0.3	3.1
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	7.4	-2.7	0.6	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	9.3	-2.6	-1.8	-3.1
Leg fat mass (left)	3.0	11.8	19.6	4.4	1.6	3.6
Lung FVC	2.9	14.5	21.7	-4.7	0.4	-4.7
Neuroticism	2.9	7.1	13.7	3.7	1.3	2.4
Hip circumference	2.9	12.5	21.0	4.6	1.0	3.9
Medication: Bendroflumethiazide	2.9	4.4	5.4	2.3	-1.7	2.2
Medication for hormone replacement therapy	2.8	3.1	4.8	2.1	0.5	2.2
Severe depression (siblings)	2.8	3.1	5.4	2.3	0.0	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.7	5.4	2.3	1.7	1.7
Arm fat mass (left)	2.8	11.6	20.4	4.5	1.3	3.6
Depressed Affect (Nagel 2018)	2.7	5.8	10.7	3.3	1.8	1.9
Schizophrenia (2018)	2.7	5.6	9.0	3.0	0.3	2.8
Hearing difficulty/problems: Yes	2.7	4.2	6.6	2.3	0.8	2.6
Fed-up feelings	2.7	5.0	7.0	2.5	2.6	1.2
Had menopause	2.7	3.4	5.4	1.5	-2.3	1.6
Arm fat percentage (right)	2.7	10.8	19.5	4.4	1.1	3.4
Pulse rate	2.7	4.5	8.1	2.9	0.4	2.3
Hypertension (Self-reported)	2.7	7.5	9.7	3.1	-1.8	3.1
Neuroticism score	2.6	5.4	11.1	3.3	1.0	2.1
Arm fat mass (right)	2.6	10.6	18.6	4.3	1.3	3.4
Breastfed as a baby	2.6	3.2	8.5	0.5	-2.9	0.9
Vascular/heart problems diagnosed by doctor	2.6	7.0	10.0	-3.0	1.3	-3.2
Leg fat percentage (left)	2.5	9.0	15.1	3.9	1.3	3.2
Blood Eosinophil Count	2.4	18.5	28.6	4.5	-2.5	5.3
Sensitivity / hurt feelings	2.4	4.1	7.9	2.8	-0.0	2.1
Hearing difficulty/problems with background noise	2.4	3.8	6.9	2.6	0.4	2.0
Falls in the last year	2.4	3.2	4.8	2.2	-0.0	2.2
Medication for pain relief, constipation, heartburn	2.4	4.1	7.0	-2.6	1.2	-2.0
Pulse rate, automated reading	2.4	7.8	13.6	3.7	-0.6	3.1
Triglycerides	2.3	3.7	5.6	-1.8	1.5	-2.4
Past tobacco smoking	2.3	4.2	6.3	-2.5	-0.5	-2.5
Medication: Amlodipine	2.3	3.3	9.1	0.7	-3.0	0.5
Health satisfaction	2.3	3.0	6.1	1.5	2.5	0.8
Average weekly champagne plus white wine intake	2.3	3.2	4.1	-2.0	-1.5	-1.8
Guilty feelings	2.3	3.4	5.4	1.7	2.3	1.4
Body mass index (BMI)	2.2	9.3	16.1	4.0	1.4	3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	6.2	2.5	-0.4	2.0
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	5.2	2.3	-0.2	1.8
Chronic bronchitis/emphysema (mother)	2.2	2.6	4.2	-2.1	0.7	-1.7
Depression (Nagel 2018)	2.1	3.1	4.5	2.1	1.4	1.7
Body Mass Index (BMI) (2010)	2.1	2.9	4.3	2.1	1.0	1.9
Type 2 Diabetes (T2D) (2018)	2.1	3.9	6.5	2.5	0.1	2.3
Medication: Levothyroxine sodium	2.1	3.5	5.5	2.4	0.1	2.2
Alcohol intake versus 10 years previously	2.1	3.1	3.7	-1.7	1.6	-1.9
Medication: Omeprazole	2.1	2.5	4.5	2.1	-1.3	1.1
Commuting to job workplace: Cycle	2.1	2.5	4.4	2.1	-1.4	1.2
Ever had hysterectomy (womb removed)	2.0	2.2	2.9	-1.7	1.6	-1.2
High blood pressure	2.0	5.6	6.9	2.6	-1.8	2.6
Qualifications: None of the above	2.0	4.2	11.6	0.8	3.4	0.7
Medication: Cholesterol lowering	2.0	3.2	5.4	2.0	0.4	2.3
Ever highly irritable/argumentative for 2 days	2.0	2.4	4.3	2.1	0.4	1.6
Neck or shoulder pain in last month	2.0	2.8	4.3	-1.5	-1.4	-2.1
Mood swings	2.0	3.6	5.7	2.4	1.8	1.4
Medication: Co-codamol	1.9	2.2	3.3	1.8	-1.3	1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	6.1	-2.5	1.3	-2.3
Fluid intelligence score	1.9	4.0	8.5	-1.3	-2.9	-1.4
Weight	1.9	9.4	14.4	3.8	1.8	3.2
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	3.9	2.0	-0.5	1.8
Qualifications: O levels/GCSEs or equivalent	1.9	3.1	3.4	-1.9	-1.8	-1.6
Exposure to tobacco smoke outside home	1.9	2.6	2.9	1.7	-1.7	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	3.3	1.6	1.2	1.8
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.3	1.3	-0.5	2.3
Blood Red Count	1.8	17.5	26.6	-5.2	2.1	-4.6
Medication: Atenolol	1.8	2.2	3.0	1.7	-1.0	1.6
Diabetes (self-reported)	1.8	2.7	4.5	2.1	-0.2	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.7	2.2	-0.4	1.2
Mineral and other dietary supplements	1.8	2.4	3.1	1.8	-1.6	1.3
Cardiovascular Disease	1.7	5.6	8.1	2.8	-2.2	2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.7	4.6	-2.1	1.5	-2.1
Shortness of breath walking on level ground	1.7	2.0	5.0	2.2	0.1	1.0
Ever depressed for a whole week	1.7	2.1	4.1	2.0	-0.4	1.4
Myopia	1.7	2.5	4.1	2.0	1.3	1.3
Chronotype (morning person)	1.6	3.7	6.1	-2.5	0.8	-2.1
Illnesses of father: Heart disease	1.6	2.3	3.8	1.3	-2.0	1.2
Diabetes diagnosed by doctor	1.6	2.7	4.4	2.1	0.8	1.7
Medication: Atorvastatin	1.6	2.0	2.8	1.4	-1.1	1.7
Neuroticism (2016)	1.5	2.2	3.8	2.0	0.8	1.4
Heel T-Score	1.5	11.9	20.7	-4.5	0.6	-3.8
Frequency of depressed mood in last 2 weeks	1.5	2.2	3.6	1.9	1.2	1.2
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.7	1.0	1.6	1.4
Medication: Metformin	1.5	2.1	2.7	1.6	1.1	1.6
Migraine (self-reported)	1.5	1.9	2.8	-1.7	0.9	-1.5
Medication: Gliclazide	1.5	1.7	2.7	1.0	1.6	1.1
BMI	1.4	8.3	15.1	3.9	1.2	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.3	5.9	-2.4	-1.2	-2.4
Medication: Paracetamol	1.4	2.4	3.8	1.7	-1.9	0.7
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	5.3	2.3	0.3	1.7
Wheeze or whistling in the chest in last year	1.4	2.5	3.4	1.8	1.7	1.1
Irritability	1.4	2.4	3.8	-1.0	1.9	-1.6
Multivitamins +/- minerals	1.3	1.6	3.9	0.7	2.0	0.6
Medication: Simvastatin	1.3	1.9	3.3	1.6	0.4	1.8
Exposure to tobacco smoke at home	1.3	1.5	2.2	1.5	0.9	1.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.4	0.6	1.8	1.0
Financial situation satisfaction	1.3	1.7	3.1	1.8	-0.2	1.4
Bipolar Disorder (2018)	1.2	1.9	2.7	1.7	-0.8	1.5
Alzheimer’s Disease (in mother)	1.2	1.4	3.2	1.8	-0.1	1.0
Age when periods started (menarche)	1.2	2.9	5.7	-2.4	-1.3	-1.1
Schizophrenia (2014)	1.1	2.5	4.1	2.0	0.3	1.8
High blood pressure (mother)	1.1	1.6	1.7	1.1	-1.3	1.3
Number of incorrect matches in round	1.1	1.8	3.8	2.0	0.2	1.3
Worrier / anxious feelings	1.1	2.1	2.8	1.7	-1.5	1.2
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	5.6	-2.2	-0.4	-2.4
Noisy workplace	1.1	1.3	3.2	-0.8	1.8	-0.4
Asthma	1.1	2.1	4.1	1.3	2.0	0.6
Loud music exposure frequency	1.1	1.3	3.7	0.1	1.9	-0.0
Qualifications: nursing, teaching	1.1	1.6	2.0	-1.4	-1.1	-1.3
Asthma (self-reported)	1.1	2.3	5.3	1.1	2.3	0.5
Neuroticism (Nagel 2018)	1.0	2.4	5.4	2.3	0.8	1.1
Worry (Nagel 2018)	1.0	2.1	4.1	2.0	-0.6	1.3
HbA1C	1.0	1.1	1.2	1.1	-1.0	1.0
Mouth/teeth dental problems	1.0	1.5	3.0	-1.0	1.7	-0.7
Allergy	1.0	2.4	5.6	0.6	-2.4	1.1
Prospective memory result	1.0	1.2	3.6	0.3	1.9	0.1
Hair/balding pattern: Pattern 4	1.0	2.4	4.7	0.9	-2.2	1.2
Family relationship satisfaction	1.0	1.2	2.0	1.4	-0.9	0.9
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.0	-1.1	-1.7	-0.8
Eye problems/disorders: Glaucoma	1.0	1.2	2.6	-1.6	0.9	-0.5
Medication: Paracetamol	1.0	1.6	2.9	1.7	-1.2	0.6
Fasting Glucose	0.9	1.1	2.6	1.6	-0.5	0.6
Lupus	0.9	1.4	2.7	-1.6	0.6	-1.1
Ulcerative Colitis	0.9	1.2	2.9	-0.9	1.7	0.2
Pack years adult smoking proportion	0.9	1.3	2.8	0.9	1.7	0.7
Leg fat-free mass (left)	0.9	4.5	6.6	2.6	1.2	2.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.9	0.9	-0.5	1.4
Nervous feelings	0.9	1.7	3.4	1.8	-0.4	1.3
Forced vital capacity (FVC), Best measure	0.9	3.2	5.0	-2.0	-0.7	-2.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.4	-1.2	0.8	-1.0
Commuting to job workplace: Walk	0.9	1.0	1.5	1.2	0.6	1.0
Osteoporosis (self-reported)	0.9	1.1	2.6	-0.8	1.6	0.1
Osteoarthritis (self-reported)	0.9	1.2	1.8	0.6	1.1	1.3
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.9	-0.3	-2.2	-1.0
Crohns Disease (2012)	0.8	1.3	2.3	1.3	0.0	1.5
Hypothyroidism (self reported)	0.8	1.7	3.1	1.8	1.0	1.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.8	0.2	2.2	-0.6
Supplements: Glucosamine	0.8	1.0	1.6	-1.2	0.3	-1.2
Leg predicted mass (left)	0.8	4.3	6.3	2.5	1.2	2.3
Forced vital capacity (FVC)	0.8	3.2	5.5	-2.0	0.5	-2.3
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.4	-1.2	-1.9	-0.9
Lung cancer (father)	0.8	1.0	2.5	-0.2	1.6	-0.6
Heart disease (mother)	0.8	1.0	1.6	1.3	0.3	1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	1.5	0.1	0.9
Ulcerative Colitis (UC)	0.7	1.3	3.5	0.0	1.9	0.6
Ovarian Cancer	0.7	0.9	1.3	1.2	-0.9	0.9
Stomach or abdominal pain in last month	0.7	0.9	1.8	1.3	-0.8	0.6
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	0.5	-1.4	-0.2
Had other major operations	0.7	0.8	2.0	-0.7	-1.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.3	1.1	0.1	1.1
Qualifications: College or University degree	0.7	2.0	6.1	-0.3	-2.5	-0.1
Mean time to correctly identify matches	0.7	1.3	2.3	1.1	-0.6	1.5
Age at last live birth	0.7	1.0	2.8	-0.5	1.7	-0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.7	-0.8	-0.3	-1.3
Miserableness	0.7	1.2	2.1	1.5	0.6	1.0
Medication: Blood pressure	0.7	1.4	2.0	1.4	-1.0	1.1
Medication: Lisinopril	0.7	1.0	2.4	0.4	1.6	0.6
Average weekly beer plus cider intake	0.7	1.1	2.6	-0.1	1.6	-0.7
Age started oral contraceptive pill	0.7	0.8	0.9	-0.9	-0.9	-0.9
Unable to work because of sickness or disability	0.7	0.8	1.3	1.1	0.4	1.1
Heart disease (siblings)	0.7	0.9	1.4	0.3	-1.1	1.2
Pack years of smoking	0.7	1.0	2.2	0.8	1.5	0.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.0	-0.9	-2.0	-0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.8	0.7	-1.3	-0.3
Bipolar Disorder (2011)	0.6	0.6	1.6	0.0	0.5	1.3
Rheumatoid Arthritis	0.6	0.8	1.4	1.0	0.1	1.2
Respiratory disease	0.6	1.2	2.6	1.0	1.6	0.5
Average weekly spirits intake	0.6	0.8	2.4	-0.0	1.5	-0.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.6	0.8	-0.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.3	1.1	1.0	0.9
Length of working week for main job	0.6	0.7	1.0	0.7	-1.0	0.8
Pulse wave reflection index	0.6	0.8	2.2	-0.3	1.5	-0.1
Age at first live birth	0.6	1.0	1.3	-0.9	1.1	-1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	0.6	-1.2	0.5
Medication: Allopurinol	0.6	0.8	1.2	1.1	0.9	0.6
Leg fat-free mass (right)	0.6	3.3	4.1	2.0	1.5	1.8
Back pain experienced in last month	0.6	0.9	1.4	-0.9	1.2	-0.7
Leg predicted mass (right)	0.6	3.1	3.8	1.9	1.5	1.8
Allergy or Eczema	0.5	1.2	2.1	1.4	1.1	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.8	1.3	0.4	0.8
Illnesses of mother	0.5	0.6	0.9	-0.9	0.4	-1.0
Worry too long after embarrassment	0.5	0.9	2.1	1.4	-0.6	0.4
Emphysema/chronic bronchitis	0.5	0.6	1.3	-0.7	1.1	-0.1
Suffer from ‘nerves’	0.5	0.8	1.3	1.2	0.9	0.4
Supplements: Vitamin C	0.5	0.6	0.7	-0.8	0.6	-0.8
Smoking status: Previous	0.5	0.8	1.2	1.1	0.4	1.1
Medication for cholesterol	0.5	0.8	1.0	-1.0	0.8	-0.8
Ever taken oral contraceptive pill	0.5	0.5	0.6	-0.8	0.6	-0.7
Illnesses of father: High blood pressure	0.5	0.7	0.9	-0.8	-0.9	-0.6
Basal metabolic rate	0.5	2.7	2.9	1.7	1.6	1.6
Major Depression (MDD)	0.4	0.4	0.9	0.9	0.3	0.6
Reaction Time	0.4	0.7	0.8	0.8	-0.9	0.8
Lung FEV1/FVC ratio	0.4	2.0	2.6	-1.6	-1.3	-1.3
Qualifications: CSEs or equivalent	0.4	0.5	1.0	0.3	1.0	-0.7
Mouth/teeth dental problems: Dentures	0.4	0.6	1.6	-0.1	1.3	-0.4
Depression (self-reported)	0.4	0.4	0.8	0.9	0.0	0.7
Peak expiratory flow (PEF)	0.4	1.0	1.4	-1.0	-0.7	-1.2
Blood clot in the leg (DVT)	0.4	0.5	0.9	-1.0	0.5	-0.6
Glaucoma (self-reported)	0.4	0.4	1.1	-1.1	0.4	-0.1
Arm fat-free mass (right)	0.4	1.8	3.1	1.1	1.8	1.0
Number of full brothers	0.4	0.5	1.3	-1.1	-0.0	-0.6
Number of children fathered	0.4	0.5	0.7	-0.8	-0.8	-0.1
Eye problems/disorders: None of the above	0.4	0.5	1.1	0.3	1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.6	0.8	-0.6	0.5
Number of full sisters	0.4	0.5	1.2	-1.1	0.3	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.2	-1.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	0.3	1.5	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	-0.6	1.0	-0.4
Number of operations (self-reported)	0.4	0.6	1.9	-0.1	-1.4	0.2
Supplements: Calcium	0.4	0.4	0.8	-0.9	0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-1.0	0.5	-0.6
Age at First Birth	0.3	0.4	0.5	-0.6	-0.7	-0.6
Height	0.3	6.1	8.5	2.6	1.8	2.9
Systolic Blood Pressure	0.3	1.3	3.4	-0.2	-1.8	-0.6
Hand grip strength (left)	0.3	0.7	1.2	-1.1	-0.1	-1.0
Diabetes (father)	0.3	0.3	0.6	0.8	-0.5	0.3
Diabetes (mother)	0.3	0.4	0.8	0.1	-0.9	-0.7
Relative age voice broke	0.3	0.4	0.7	-0.9	0.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.7	0.6	0.3
Impedance of leg (left)	0.3	1.3	2.1	-1.5	0.3	-1.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	0.1	1.1	-0.4
Pain all over the body in last month	0.3	0.3	0.7	0.8	-0.4	0.1
Impedance of arm (left)	0.3	1.2	1.8	1.0	-1.4	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.8	0.6	0.5
Arm predicted mass (right)	0.3	1.8	2.8	1.2	1.7	1.1
Chest pain or discomfort	0.3	0.5	1.2	1.1	0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.6	-0.5	-0.8	-0.6
Whole body fat-free mass	0.3	1.6	2.4	1.1	1.6	1.1
Ever had bowel cancer screening	0.3	0.3	0.6	0.8	-0.4	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.6	-0.7	0.2
Friendships satisfaction	0.3	0.4	1.2	1.1	0.0	0.3
Whole body water mass	0.3	1.6	2.4	1.1	1.6	1.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.5	0.7	0.3	0.7
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.4	0.8	-0.6
High cholesterol (Self-reported)	0.3	0.6	0.6	0.8	-0.8	0.7
Arm fat-free mass (left)	0.3	1.7	3.5	0.8	1.9	0.9
Risk taking	0.3	0.5	0.7	0.4	0.7	0.8
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.0	-1.0	-0.5
Diastolic blood pressure, automated reading	0.3	1.0	2.4	0.3	-1.5	0.8
Alzheimer’s Disease (in father)	0.2	0.3	0.8	0.0	-0.9	-0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.4	0.5	0.5
Systolic blood pressure, automated reading	0.2	0.5	1.1	0.4	-1.0	0.5
Vitamin and mineral supplements	0.2	0.3	0.9	-0.2	-0.9	0.0
Supplements: Zinc	0.2	0.2	0.4	0.2	0.7	0.1
Hand grip strength (right)	0.2	0.5	0.7	-0.8	0.3	-0.8
Average weekly fortified wine intake	0.2	0.2	0.4	0.3	-0.6	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.3	-0.6	0.4
Impedance of arm (right)	0.2	0.7	1.7	0.5	-1.3	0.5
Time employed in main current job	0.2	0.2	0.5	0.4	-0.7	0.3
Number of live births	0.2	0.3	0.4	-0.7	0.2	-0.6
Headache pain in last month	0.2	0.4	0.7	-0.4	-0.8	-0.6
Alcohol intake frequency.	0.2	0.5	0.8	0.6	-0.7	0.9
Leg pain on walking	0.2	0.3	0.7	0.2	0.8	0.2
Arm predicted mass (left)	0.2	1.2	3.1	0.6	1.7	0.5
Crohns Disease (2017)	0.1	0.3	0.8	0.2	-0.9	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	0.0	1.0	0.2
LDL Cholesterol	0.1	0.2	0.3	-0.0	-0.6	0.5
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.5	-0.3	0.3
Waist Hip Ratio (WHR)	0.1	0.6	1.5	-0.3	1.2	0.2
Hair Pigment	0.1	2.3	3.1	1.5	1.2	1.8
Relative age of first facial hair	0.1	0.2	0.5	-0.7	0.5	0.3
Impedance of leg (right)	0.1	0.5	0.8	-0.9	-0.5	-0.6
Maternal smoking around birth	0.1	0.1	0.3	-0.6	0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	-0.4	0.6	-0.1
Trunk fat-free mass	0.1	0.7	1.8	0.3	1.4	0.5
Medication: Lansoprazole	0.1	0.1	0.3	0.5	-0.1	0.2
Trunk predicted mass	0.1	0.7	1.9	0.3	1.4	0.5
Standing height	0.1	0.7	1.8	-0.3	1.4	0.3
Tense / ‘highly strung’	0.1	0.1	0.2	-0.0	-0.2	-0.5
Birth weight	0.1	0.1	0.3	-0.1	-0.6	-0.2
Comparative height size at age 10	0.1	0.5	1.1	1.0	0.1	0.6
Had major operations	0.1	0.1	0.3	0.2	0.0	0.5
Average weekly red wine intake	0.1	0.1	0.3	-0.2	-0.3	-0.6
Mother’s age at death	0.1	0.1	0.1	-0.3	0.0	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.3	0.5	-0.1
Pain experienced in last month	0.1	0.2	0.3	-0.5	-0.1	-0.4
Alcohol drinker status: Previous	0.1	0.2	0.3	0.5	-0.3	0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.1	0.3	0.2	-0.5	0.4
Sitting height	0.0	0.1	0.2	0.2	0.4	0.2
Father’s age at death	0.0	0.0	0.1	-0.2	0.1	-0.2
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.3	0.4	0.2
Gout (self-reported)	0.0	0.0	0.0	0.1	-0.0	-0.0
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	0.2	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.2	-0.3	-0.0
Breast cancer (self-reported)	0.0	0.0	0.1	-0.1	-0.1	0.3
Wears glasses or contact lenses	0.0	0.0	0.1	-0.3	0.0	-0.0
Cholesterol lowering medication	0.0	0.0	0.0	0.1	-0.2	-0.0
Impedance of whole body	0.0	0.1	0.4	-0.0	-0.6	-0.1

Hub : Genes

RHOF

Models

Trait associations