Hub : Genes

PRKAB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.5830	0.1470	7.1e-03	0.057	NA	0.084	NA	0.069	1.2e-02	NA	3.0e-03	NA	6.6e-03
2	GTEx	Cells Transformed fibroblasts	0.2350	0.0790	3.8e-04	0.278	NA	0.313	NA	0.313	4.9e-21	NA	6.1e-24	NA	6.0e-24
3	GTEx	Esophagus Mucosa	0.3830	0.0730	4.4e-09	0.323	NA	0.293	NA	0.321	3.6e-22	NA	6.4e-20	NA	5.4e-22
4	GTEx	Nerve Tibial	0.1095	0.0420	4.8e-04	0.098	NA	0.032	NA	0.066	2.1e-07	NA	2.3e-03	NA	2.1e-05
5	GTEx	Whole Blood	0.1040	0.0340	1.3e-05	0.048	NA	0.045	NA	0.073	3.0e-05	NA	5.0e-05	NA	3.0e-07
6	METSIM	Adipose	0.1096	0.0436	2.0e-03	0.091	0.007	0.077	0.089	0.086	1.9e-13	2.8e-02	1.1e-11	2.7e-13	8.0e-13
7	NTR	Blood	0.0225	0.0107	8.5e-03	0.022	0.002	0.015	0.012	0.020	9.5e-08	5.0e-02	1.1e-05	7.0e-05	4.0e-07
8	YFS	Blood	0.4002	0.0400	0.0e+00	0.174	0.176	0.228	0.229	0.234	1.3e-54	3.2e-55	4.2e-73	1.6e-73	3.9e-75
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0236	0.0154	3.6e-03	0.009	0.013	0.009	NA	0.009	3.0e-02	1.1e-02	3.2e-02	NA	3.0e-02
10	TCGA	Thyroid Carcinoma	0.0350	0.0230	1.9e-03	0.018	0.026	0.013	NA	0.015	6.8e-03	1.2e-03	1.9e-02	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.8	1.3	4.0	1.6	-0.1	-0.5	1.8	2.0	-0.3	-0.1	0.2	-1.1	-1.2
Bipolar Disorder or Schizophrenia	2.7	6.6	19.2	1.6	0.4	-0.2	3.6	4.4	0.7	0.1	2.0	-3.7	-3.6
Depressed Affect (Nagel 2018)	2.0	4.1	11.2	-3.4	2.6	2.4	-1.0	-0.6	1.5	2.3	2.0	1.5	1.6
Depression (Nagel 2018)	1.4	2.1	5.1	-1.6	1.9	1.8	0.2	1.3	1.2	1.7	2.3	-0.5	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	3.3	-1.8	0.3	0.3	0.5	0.0	0.9	0.6	0.6	-0.6	-0.7
Neuroticism (Nagel 2018)	1.0	2.3	19.9	-4.5	0.5	0.0	0.6	1.1	-0.6	0.2	0.8	-0.1	-0.0
Schizophrenia (2018)	3.0	6.3	16.2	0.7	0.5	0.1	3.2	4.0	1.1	0.3	2.4	-3.9	-3.7
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	-1.5	0.6	0.7	-0.1	0.3	1.0	0.8	1.1	-1.0	-0.9
Worry (Nagel 2018)	1.6	3.4	14.2	-3.8	-0.9	-1.5	1.9	2.3	-1.7	-1.4	-0.1	-1.2	-1.3
Alzheimer’s Disease (in mother)	1.1	1.3	2.8	0.3	1.2	1.7	-1.0	-1.4	1.5	1.4	1.2	0.3	0.3
Alzheimer’s Disease (in father)	3.5	3.8	7.8	0.7	-2.7	-2.8	1.0	1.3	-2.1	-2.1	-1.9	-1.8	-2.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.9	0.1	-0.6	-0.2	-0.1	-0.3	-0.0	-0.1	-0.0	-0.9	-1.0
Crohns Disease (2017)	4.5	9.8	19.5	-0.4	4.3	4.0	-1.5	-1.4	3.9	4.4	3.5	2.7	2.3
Irritable Bowel Disease (IBD)	3.8	9.0	18.9	-0.1	4.3	4.0	-0.6	-0.8	3.9	4.3	3.8	1.8	1.5
Ulcerative Colitis (UC)	2.4	4.6	10.0	0.2	3.0	3.0	0.0	-0.4	2.9	3.2	2.9	0.8	0.7
Major Depression (MDD)	0.5	0.6	1.4	-0.5	0.8	1.0	-1.2	-0.7	1.0	1.0	0.7	0.2	0.0
Reaction Time	2.1	4.1	10.5	-2.0	-1.5	-1.2	1.9	2.8	-1.0	-0.7	-0.3	-3.2	-3.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.5	-1.2	0.1	0.3	0.4	-0.1	0.6	0.0	0.3	-0.5	-0.6
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.3	1.7	3.4	1.0	-1.7	-1.7	0.8	0.7	-1.7	-1.9	-1.3	-0.7	-0.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.7	1.0	3.1	0.7	-0.2	0.3	-1.5	-1.8	-0.0	-0.2	-0.6	1.3	1.3
Bipolar Disorder (2011)	2.2	2.2	7.5	2.7	-1.6	-1.6	0.0	1.3	-1.5	-1.2	-1.1	-1.1	-1.1
Body Mass Index (BMI) (2010)	0.7	0.9	2.2	-0.5	1.1	1.2	-0.9	-1.0	1.5	1.0	1.0	0.3	-0.0
Coronary Artery Disease (CAD)	3.4	4.1	7.3	0.5	2.4	2.6	0.0	-2.2	1.9	2.7	1.5	2.0	2.5
Crohns Disease (2012)	3.4	5.4	10.8	0.4	3.1	2.9	-1.6	-1.3	2.7	3.3	2.3	2.3	1.8
Mean Putamen Volume	1.0	1.2	2.6	-1.0	-0.2	-0.4	-1.3	-1.5	-0.8	-0.4	-1.0	1.6	1.4
Fasting Glucose	1.2	1.4	3.6	0.3	-1.4	-1.2	-0.1	-0.9	-1.6	-1.5	-1.9	0.6	0.6
HbA1C	0.3	0.3	1.0	-1.0	0.1	0.1	-0.9	-0.4	-0.1	0.3	-0.2	0.8	0.8
HDL Cholesterol	0.4	0.7	1.6	1.1	-0.9	-1.1	1.2	0.4	-1.2	-0.8	-0.7	-0.4	-0.2
LDL Cholesterol	1.5	2.4	4.8	-0.8	1.7	1.6	-1.3	-1.7	1.1	1.7	0.8	2.0	2.2
Lupus	0.2	0.3	0.9	0.9	-0.4	-0.5	-0.1	0.5	-0.2	-0.9	-0.4	-0.1	-0.3
Neuroticism (2016)	0.7	1.0	2.8	-1.3	-0.1	-0.3	1.1	1.7	-0.4	-0.1	0.4	-1.6	-1.3
Primary Biliary Cirrhosis	2.1	3.0	6.7	0.3	2.6	2.3	-0.2	-0.1	2.2	2.3	2.4	1.2	0.8
Rheumatoid Arthritis	0.6	0.8	2.1	-1.2	-1.1	-1.0	-0.8	-0.2	-0.9	-0.7	-1.4	0.6	0.1
Schizophrenia (2014)	1.8	4.0	9.6	0.7	0.6	0.2	2.3	3.1	1.0	0.4	2.0	-3.1	-3.0
Triglycerides	0.1	0.2	1.3	-1.1	0.2	0.3	-0.5	-0.1	0.3	0.3	0.1	0.2	-0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.2	-0.1	-0.5	-0.7	-0.6	0.3	-0.0
Ulcerative Colitis	1.7	2.5	5.2	0.9	2.0	2.1	0.6	0.3	2.1	2.3	2.3	-0.2	-0.4
Blood Eosinophil Count	0.3	2.5	5.2	-1.0	-2.3	-2.2	0.4	0.9	-2.1	-1.5	-2.0	-1.0	-0.8
Blood Platelet Count	0.2	2.2	5.6	0.4	-2.1	-1.6	-0.7	-1.1	-2.0	-1.7	-2.4	0.5	0.4
Blood Red Count	0.1	1.2	3.5	1.3	0.8	1.1	-1.3	-0.4	1.9	1.2	1.1	-0.3	-0.7
Blood White Count	3.6	27.0	63.2	-0.4	-7.4	-7.0	0.2	-0.7	-7.4	-6.8	-8.0	-0.2	0.1
Heel T-Score	0.3	2.4	4.8	1.7	-2.1	-1.9	-0.3	-0.8	-1.8	-2.0	-2.2	-0.1	-0.1
BMI	0.4	2.6	5.3	0.0	1.7	1.7	-1.5	-1.7	1.9	1.5	0.6	1.7	2.3
Height	0.1	2.4	7.2	-1.5	-1.2	-1.0	1.5	2.0	-0.5	-0.6	-0.1	-2.2	-2.7
Waist Hip Ratio (WHR)	0.2	0.8	1.4	0.8	-1.0	-0.6	0.9	1.2	-1.0	-0.7	-0.4	-1.0	-0.9
Systolic Blood Pressure	1.7	8.7	21.4	-0.2	1.7	2.2	-4.3	-4.6	1.5	1.6	-0.1	4.3	4.1
Smoking Status	0.9	2.2	4.9	0.5	1.9	1.7	1.4	1.8	1.3	1.3	2.2	-1.4	-0.6
Allergy or Eczema	0.5	1.3	3.1	-1.2	1.5	1.3	-0.1	0.2	1.8	1.2	1.5	0.6	0.2
Cardiovascular Disease	1.3	4.2	9.7	-1.3	1.2	1.5	-2.5	-3.1	0.7	1.1	-0.3	3.1	3.1
Hypothyroidism (self reported)	0.1	0.2	0.6	-0.2	-0.2	-0.6	0.4	-0.1	-0.6	-0.8	-0.5	-0.3	0.2
Respiratory disease	1.1	2.5	5.8	-1.0	1.9	1.9	-1.0	-0.2	2.4	2.1	2.2	0.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.4	0.6	0.4	0.3	0.4	0.4	0.4	0.1	0.4	-0.1	-0.1
Lung FEV1/FVC ratio	0.3	1.7	3.4	0.9	1.1	1.3	-1.9	-1.4	1.2	1.1	0.2	1.8	1.4
Lung FVC	0.4	1.8	5.4	-0.6	0.9	0.5	2.3	1.3	0.7	-0.1	1.7	-2.0	-1.5
Neuroticism	0.6	1.6	11.5	-3.4	0.1	-0.6	0.8	1.5	-0.8	-0.4	0.2	-0.4	-0.2
Chronotype (morning person)	0.4	0.9	2.4	-0.5	-0.9	-0.9	-1.5	-1.0	-0.6	-0.3	-1.3	1.2	0.4
Hair Pigment	0.0	0.5	1.0	-0.9	-0.7	-0.9	0.2	0.5	-1.0	-1.0	-0.8	-0.3	-0.1
Tanning	0.1	1.1	3.9	-2.0	0.3	0.5	-1.6	-1.4	0.4	0.1	-0.1	1.0	0.8
Hand grip strength (left)	0.2	0.6	1.6	1.3	0.9	0.7	-0.5	-1.0	0.9	0.4	0.6	0.1	0.3
Number of treatments/medications taken	0.2	0.4	1.0	-1.0	0.4	0.2	-0.9	-0.7	0.0	0.1	-0.3	1.0	1.0
Average weekly spirits intake	2.1	2.6	6.9	1.1	0.6	0.9	-2.0	-2.6	0.6	0.4	-0.6	2.4	2.4
Sensitivity / hurt feelings	0.9	1.5	2.3	-1.3	-1.4	-1.3	0.9	1.2	-1.5	-0.7	-0.9	-1.5	-1.1
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.0	-1.7	0.4	0.3	1.0	1.7	-0.1	0.6	1.0	-1.3	-0.8
Hearing difficulty/problems: Yes	0.4	0.7	2.6	-1.2	0.4	0.3	-0.1	-0.9	0.1	0.2	-0.0	1.3	1.6
Relative age of first facial hair	0.6	1.3	3.2	-0.0	-1.1	-1.1	1.2	1.3	-0.8	-0.9	-0.2	-1.6	-1.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.9	1.7	-0.2	-0.0	0.0	0.4	0.0	-0.7	-0.0	-0.7	-0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.7	-0.7	-1.2	-1.0	-0.1	0.1	-1.3	-1.0	-1.2	0.1	-0.0
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	0.1	-0.5	-0.2	-1.0	-0.8	-0.5	0.0	-0.6	0.5	0.2
Systolic blood pressure, automated reading	4.7	13.5	22.8	-0.2	3.5	3.8	-4.5	-4.8	3.5	3.5	1.7	4.5	4.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	-0.7	0.1	0.2	-0.3	0.1	0.2	1.0	0.2	0.4	-0.1
Angina	0.4	0.6	1.7	-0.6	-1.1	-0.9	-0.1	-0.1	-1.0	-0.7	-1.3	-0.2	-0.2
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.2	-0.8	-0.6	0.3	0.3	-0.7	-0.8	-0.6	-0.6	-0.3
Vitamin and mineral supplements	1.7	2.3	4.9	0.7	-0.7	-0.6	-2.1	-2.1	-0.9	-0.7	-1.7	2.1	2.2
Supplements: Zinc	0.7	0.7	1.8	-1.4	0.9	0.9	0.3	0.6	1.0	0.5	1.2	-0.5	-0.2
Medication: Co-codamol	0.1	0.1	0.3	-0.2	0.4	0.3	0.5	0.3	-0.1	-0.2	0.1	0.0	0.5
Medication: Metformin	0.4	0.6	1.8	0.1	0.0	0.2	-1.0	-1.3	-0.2	-0.1	-0.5	1.0	1.2
Diabetes (father)	1.4	1.8	4.3	0.7	1.9	1.7	0.5	0.5	1.8	1.5	2.1	-0.5	-0.2
Diabetes (mother)	0.3	0.4	0.9	0.7	0.9	0.6	0.4	0.5	0.7	0.6	1.0	0.2	0.2
Severe depression (siblings)	1.5	1.7	4.7	0.8	1.4	1.3	0.2	0.7	2.2	1.7	1.8	-0.4	-0.8
Pack years adult smoking proportion	0.1	0.1	0.4	0.2	-0.2	-0.2	-0.2	0.6	-0.5	-0.3	-0.3	-0.1	0.2
Impedance of leg (right)	0.4	2.1	3.4	-1.8	1.3	1.7	-1.8	-1.4	1.3	1.6	1.0	1.5	0.7
Leg fat-free mass (left)	0.3	1.3	2.6	-0.9	-1.2	-1.6	1.0	1.2	-1.2	-1.5	-1.1	-1.0	-0.3
Trunk fat percentage	0.8	3.2	9.0	-0.8	0.1	0.5	-3.0	-2.6	0.2	0.4	-1.3	2.6	2.5
Hand grip strength (right)	0.1	0.3	0.8	0.5	0.8	0.5	-0.1	-0.5	0.9	0.5	0.7	0.2	0.1
Townsend deprivation index at recruitment	1.2	1.6	3.9	0.5	-1.3	-1.2	1.5	1.3	-1.3	-0.9	-0.8	-2.0	-1.3
Current tobacco smoking	0.6	1.0	2.6	1.3	0.5	0.5	1.0	1.2	0.6	0.4	1.0	-1.6	-1.1
Average weekly fortified wine intake	0.3	0.3	1.3	0.0	-0.9	-0.5	-0.7	-0.5	-0.4	0.0	-1.1	0.3	0.1
Maternal smoking around birth	2.3	3.4	12.4	1.1	-0.3	-0.3	1.7	2.8	0.2	-0.1	1.0	-2.9	-3.5
Fed-up feelings	1.1	1.9	4.9	-2.2	0.0	0.0	-1.3	-1.4	-0.8	-0.2	-0.9	2.2	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	-0.1	-0.1	-0.2	1.0	1.4	-0.8	-0.6	0.2	-0.8	-0.5
Relative age voice broke	0.3	0.4	1.7	1.3	-0.2	-0.1	0.7	0.5	-0.2	-0.0	0.3	-0.8	-1.0
Taking other prescription medications	0.4	0.7	2.0	-1.4	-0.0	-0.3	-0.6	-0.7	-0.5	-0.3	-0.7	1.1	1.2
Age when periods started (menarche)	0.3	0.8	4.4	2.1	-0.2	-0.1	0.8	0.9	-0.3	-0.2	0.2	-1.1	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	0.5	-1.0	-0.9	-0.4	-0.3	-0.7	-0.5	-1.0	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.1	0.9	-1.6	-1.6	-1.1	-0.9	-1.2	-1.5	-2.0	0.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.0	-0.3	-0.1	-0.1	-0.3	-0.1	-0.2	-0.3	-0.2	0.1
Qualifications: CSEs or equivalent	0.2	0.3	2.6	1.6	-0.2	-0.1	0.3	0.0	0.1	0.2	-0.1	-0.6	-0.4
Serious illness, injury or assault to yourself	1.6	2.0	6.2	-0.8	0.3	0.1	-1.6	-2.2	-0.1	-0.5	-0.9	2.5	2.1
High blood pressure	2.1	5.9	12.7	-1.8	1.6	2.1	-3.2	-3.6	1.2	1.5	0.2	3.3	3.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	-1.2	0.8	0.7	-0.0	0.3	1.3	0.6	1.0	0.1	-0.3
Multivitamins +/- minerals	2.0	2.6	6.3	-1.7	0.7	1.0	1.6	1.8	1.1	1.0	1.8	-2.0	-2.5
Stomach or abdominal pain in last month	0.2	0.2	0.8	0.5	0.0	-0.3	0.3	0.9	-0.2	-0.8	-0.2	-0.1	-0.3
Supplements: Glucosamine	0.8	1.1	6.7	-2.6	-0.2	-0.2	-0.3	-0.6	-0.7	-0.4	-0.4	1.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	0.5	0.8	0.9	-0.8	-0.7	0.6	1.2	0.3	0.9	1.1
Medication: Atenolol	0.7	0.9	1.7	-0.1	0.9	0.9	-0.7	-1.3	1.0	1.1	0.4	1.2	1.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.0	0.2	-0.2	0.1	-0.2	0.1	-0.2	0.2	-0.1	0.0
Sitting height	0.1	0.5	2.6	-1.6	0.4	0.4	-0.6	-0.6	0.4	0.2	0.1	0.7	0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-0.1	0.6	0.7	-0.9	-1.1	0.4	0.1	0.2	1.0	0.9
High blood pressure (mother)	0.9	1.3	2.1	-1.5	-0.9	-0.8	-0.9	-1.2	-1.4	-0.7	-1.4	1.0	1.1
Body mass index (BMI)	0.4	1.6	5.0	0.3	0.3	0.4	-1.9	-1.9	0.5	0.4	-0.7	1.7	2.2
Impedance of leg (left)	0.5	2.6	4.8	-1.3	1.4	1.8	-2.2	-1.7	1.3	1.8	1.0	1.9	1.0
Leg predicted mass (left)	0.2	1.3	2.6	-0.8	-1.2	-1.6	1.0	1.2	-1.1	-1.4	-1.1	-1.0	-0.3
Trunk fat mass	0.6	2.7	7.0	-1.1	0.0	0.3	-2.7	-2.3	0.1	0.3	-1.2	2.3	2.4
Waist circumference	0.1	0.4	1.2	-0.3	-0.4	-0.2	-0.8	-0.6	-0.3	-0.3	-1.0	0.7	1.1
Number of incorrect matches in round	0.7	1.1	1.9	0.0	-1.2	-1.4	0.6	0.8	-1.4	-1.4	-1.0	-1.1	-0.9
Past tobacco smoking	0.4	0.7	1.6	-0.3	-1.3	-1.1	-0.5	-1.0	-0.5	-0.6	-1.3	0.6	0.2
Alcohol usually taken with meals	0.3	0.5	1.3	-0.3	-1.2	-1.0	0.0	0.1	-0.7	-0.9	-1.0	-0.4	-0.6
Nervous feelings	1.0	1.9	7.8	-2.8	-0.4	-1.1	1.6	1.8	-1.1	-0.4	-0.0	-1.3	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.9	-1.5	-1.4	-1.4	1.2	1.5	-1.7	-1.7	-1.1	-1.1	-0.8
Hearing difficulty/problems with background noise	1.4	2.2	4.9	-1.6	-1.4	-1.9	1.5	0.8	-2.0	-2.2	-1.5	-0.5	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	2.0	-1.4	0.7	0.6	-0.8	-0.2	0.4	0.4	0.5	1.0	0.4
Had menopause	0.7	0.9	2.5	-1.2	0.7	0.7	-1.1	-1.1	0.4	0.2	0.2	1.6	1.3
Had other major operations	0.3	0.4	2.7	-1.6	0.5	0.4	0.2	-0.2	0.4	0.3	0.5	0.3	0.2
Forced vital capacity (FVC)	0.2	0.8	2.5	-1.6	0.4	0.3	1.3	0.5	0.5	-0.1	0.8	-1.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	6.9	1.0	-2.2	-2.0	-1.3	-1.5	-1.6	-1.8	-2.6	0.7	0.8
Ever unenthusiastic/disinterested for a whole week	1.9	2.4	7.1	0.8	-0.3	-0.6	2.6	2.7	-0.6	-1.1	0.4	-2.0	-1.7
Qualifications: None of the above	1.1	2.5	5.8	-1.2	1.2	1.7	-2.4	-1.6	1.1	1.9	0.6	1.7	1.5
Financial difficulties in last 2 years	2.0	2.7	8.3	0.8	-0.7	-0.5	2.4	2.2	-0.3	-0.8	0.6	-2.9	-2.4
Mouth/teeth dental problems	1.1	1.6	3.7	-0.7	1.7	1.6	-0.7	-0.4	1.9	1.8	1.5	0.9	0.2
Heart attack	0.2	0.2	1.0	1.0	0.2	0.3	-0.5	-0.4	0.5	0.3	-0.1	0.3	0.2
Allergy	0.1	0.3	1.5	1.2	-0.1	-0.2	0.4	-0.4	-0.6	-0.4	-0.5	0.3	0.6
Pain all over the body in last month	1.2	1.3	2.3	-0.3	-0.8	-0.8	-1.3	-1.0	-1.2	-1.3	-1.5	1.1	1.5
Diabetes (self-reported)	0.4	0.6	1.5	-0.3	0.7	0.7	-0.9	-1.1	0.4	0.4	0.2	1.2	1.1
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	6.6	-2.6	0.7	0.8	-1.3	-1.6	0.8	1.1	0.0	1.9	1.4
Medication: Ramipril	1.1	1.5	6.7	2.6	0.9	1.0	-1.2	-1.3	0.9	1.3	0.6	0.1	0.6
Medication: Simvastatin	0.9	1.3	3.1	-0.5	0.9	1.1	-1.5	-1.3	0.4	1.2	0.2	1.3	1.8
Fluid intelligence score	0.3	0.6	1.6	-1.3	-0.6	-0.8	0.9	0.3	-0.6	-1.0	-0.4	-0.5	-0.3
Illnesses of siblings	0.5	0.6	1.7	0.1	-1.0	-1.1	0.2	-0.1	-1.0	-1.3	-1.0	-0.7	-0.1
Neuroticism score	0.7	1.4	6.6	-2.6	-0.7	-1.0	0.8	1.4	-1.3	-0.8	-0.5	-0.7	-0.5
Weight	0.2	1.0	2.8	-0.9	-0.3	-0.3	-1.4	-1.2	-0.1	-0.1	-1.1	1.2	1.7
Impedance of arm (right)	0.2	0.8	2.6	-1.4	-0.8	-0.3	0.5	1.1	-0.5	-0.3	-0.0	-1.2	-1.6
Arm fat percentage (right)	0.2	1.0	2.9	-0.3	-0.1	0.2	-1.7	-1.4	0.1	0.2	-0.9	1.2	1.6
Trunk fat-free mass	0.1	0.4	1.8	-1.3	-0.5	-0.8	0.4	0.5	-0.3	-0.6	-0.5	-0.5	0.1
Hip circumference	0.2	0.8	1.9	-1.3	-0.1	-0.1	-1.4	-1.0	0.2	-0.1	-0.9	0.8	1.2
Time employed in main current job	0.2	0.3	0.9	-0.9	-0.4	-0.5	0.1	0.5	-0.3	-0.5	-0.3	-0.3	-0.7
Alcohol intake versus 10 years previously	3.7	5.6	9.9	-0.2	-3.1	-2.6	1.8	1.5	-2.7	-2.8	-2.1	-3.0	-2.4
Father’s age at death	0.4	0.6	1.0	-1.0	0.5	0.6	0.3	0.6	0.8	0.9	1.0	-0.5	-0.8
Worrier / anxious feelings	0.8	1.5	7.1	-2.7	-0.5	-1.0	-0.2	0.4	-1.3	-1.1	-0.9	1.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.8	0.7	0.5	0.2	0.3	0.2	0.2	0.5	0.2	0.5
Falls in the last year	0.9	1.2	2.8	-0.1	1.4	1.7	-0.6	-0.4	1.6	1.4	1.2	0.0	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.7	0.2	0.5	-0.3	0.1	0.9	0.7	0.5	-0.9	-0.6
Number of live births	0.4	0.6	1.0	-1.0	-0.8	-0.9	0.6	0.7	-0.9	-0.5	-0.6	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.1	-1.5	0.6	0.5	1.1	0.4	0.7	0.1	0.9	-0.8	-0.6
Pulse rate	0.4	0.6	2.0	-1.0	-0.5	-0.4	0.7	1.4	-0.3	-0.2	0.1	-0.9	-1.1
Happiness	0.4	0.4	1.4	1.2	0.6	0.7	0.8	0.5	0.5	0.3	0.8	-0.4	-0.3
Noisy workplace	0.3	0.4	1.1	0.3	0.1	0.6	-1.1	-0.8	0.2	0.6	-0.3	0.7	0.9
Qualifications: A levels/AS levels or equivalent	1.3	2.9	7.1	0.5	0.3	-0.2	2.7	2.6	0.5	0.2	1.5	-2.5	-2.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.6	-0.4	-0.1	0.0	-0.3	-0.8	0.2	0.0	-0.5	0.3	0.6
Mouth/teeth dental problems: Dentures	1.7	3.0	8.5	0.6	-0.6	-0.3	-1.6	-2.5	-1.1	-0.7	-1.8	2.5	2.9
Asthma	0.6	1.2	3.0	-0.6	0.9	1.3	-1.3	-0.4	1.5	1.7	1.3	-0.5	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.7	1.6	-0.9	-0.9	0.4	0.8	-0.6	-0.9	-0.4	-1.2	-1.1
Medication: Cholesterol lowering	1.9	3.0	5.8	-0.2	1.6	1.8	-2.2	-2.0	1.2	1.6	0.4	2.3	2.4
Depression (self-reported)	0.3	0.4	2.2	-1.5	0.6	0.5	0.1	0.1	0.2	0.7	0.7	0.2	0.6
Medication: Lansoprazole	0.4	0.5	1.1	0.6	-0.9	-0.9	-0.4	0.0	-1.0	-0.8	-1.0	0.4	0.2
Prospective memory result	0.2	0.2	0.8	0.4	0.4	0.5	0.2	-0.3	-0.2	0.1	0.2	0.8	0.9
Lung cancer (father)	0.2	0.2	0.4	0.3	-0.2	-0.4	-0.2	-0.4	-0.6	-0.3	-0.7	0.5	0.6
Illnesses of mother	0.1	0.2	0.4	0.0	0.1	0.1	-0.4	-0.6	0.2	0.5	-0.3	0.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	-0.7	0.5	0.5	0.8	-0.2	0.6	0.2	0.5	-0.4	-0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	0.2	-0.8	-0.7	0.1	0.4	-0.5	-0.8	-0.5	-0.6	-0.8
Impedance of arm (left)	0.1	0.3	1.0	-0.9	-0.5	-0.1	0.1	0.5	-0.2	-0.2	-0.0	-0.4	-1.0
Arm fat mass (right)	0.3	1.4	4.1	-0.7	0.0	0.2	-1.9	-1.6	0.2	0.2	-1.0	1.6	2.0
Trunk predicted mass	0.1	0.4	1.6	-1.3	-0.5	-0.8	0.6	0.7	-0.3	-0.6	-0.4	-0.7	-0.1
Standing height	0.2	1.7	6.0	-2.5	-1.1	-1.3	1.0	1.4	-1.0	-1.1	-0.7	-1.0	-1.1
Length of working week for main job	1.0	1.1	7.8	2.8	0.1	-0.0	0.7	1.2	0.2	-0.1	0.2	-0.8	-0.7
Exposure to tobacco smoke at home	1.2	1.3	3.0	-0.7	-1.7	-1.6	-0.0	0.2	-1.6	-1.2	-1.7	-0.4	-0.4
Breastfed as a baby	1.1	1.3	3.9	0.5	0.2	0.3	1.1	1.5	0.5	0.5	1.2	-2.0	-2.0
Tense / ‘highly strung’	2.8	4.6	11.0	-1.3	-0.7	-1.1	3.3	3.3	-0.7	-1.0	0.8	-3.0	-3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	6.1	-2.5	0.2	0.5	0.3	0.8	0.3	0.3	0.7	-1.1	-0.8
Hair/balding pattern: Pattern 4	0.1	0.3	1.1	0.2	0.6	0.3	0.2	-0.7	0.2	0.2	0.2	1.0	1.1
Birth weight of first child	2.9	5.2	9.4	-2.1	1.7	2.1	-2.6	-3.0	1.7	2.1	0.7	3.1	2.7
Peak expiratory flow (PEF)	1.0	2.2	5.3	-0.5	2.3	2.1	0.3	-0.2	2.2	1.6	2.1	0.3	0.5
Pulse wave reflection index	0.3	0.4	1.0	0.7	0.5	0.5	-1.0	-0.8	0.7	0.3	0.3	0.6	0.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.7	-0.3	-0.6	-0.6	1.4	1.3	-0.4	-0.8	0.1	-1.6	-1.4
Loud music exposure frequency	0.2	0.2	0.4	0.6	0.5	0.4	0.4	0.5	0.3	0.0	0.6	-0.7	-0.2
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	6.8	0.9	-2.4	-2.6	1.5	1.4	-2.1	-2.5	-1.9	-1.2	-1.4
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	5.3	0.5	-1.3	-1.7	2.2	1.8	-1.4	-1.8	-0.7	-2.3	-1.8
Blood clot in the leg (DVT)	0.6	0.7	1.9	0.3	-1.2	-1.2	-0.1	0.4	-1.4	-1.0	-1.0	-0.4	-0.3
Medication: Paracetamol	0.2	0.4	0.8	-0.5	-0.4	-0.3	-0.9	-0.5	-0.6	-0.4	-0.8	0.5	0.9
Headache pain in last month	0.4	0.6	1.9	-0.3	0.9	1.1	-0.2	0.2	1.4	1.0	1.1	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	6.3	0.2	-1.0	-1.2	2.0	2.3	-0.5	-0.8	0.1	-2.5	-2.3
Glaucoma (self-reported)	1.6	1.9	4.4	0.7	-2.1	-1.8	0.5	0.0	-1.8	-1.6	-1.8	-0.9	-0.9
Gout (self-reported)	0.6	0.8	2.0	-1.3	0.8	0.4	-0.5	-0.7	0.4	0.9	0.3	1.2	1.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.9	-0.2	-0.8	-1.1	0.3	-0.2	-0.9	-1.4	-0.9	-0.1	0.1
Medication: Amlodipine	0.2	0.3	1.0	-0.2	1.0	0.6	0.5	0.4	0.7	-0.0	0.7	0.5	0.0
Medication: Ventolin 100micrograms inhaler	0.7	1.0	1.9	-0.7	-1.4	-1.2	-0.0	0.5	-1.2	-0.7	-0.9	-1.1	-1.2
Birth weight	0.2	0.4	1.1	-0.2	0.9	0.7	-0.5	0.1	1.0	1.1	0.9	0.2	0.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.7	0.5	0.2	0.2	0.8	0.3	0.5	0.8	-0.1	-0.3
High blood pressure (siblings)	0.6	0.8	1.3	-0.8	1.0	1.0	-1.1	-0.6	0.8	1.1	0.6	1.1	0.7
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	-1.0	0.4	0.4	1.0	0.1	0.7	0.3	0.8	-0.8	-0.5
Body fat percentage	0.9	3.5	10.0	-0.7	0.5	0.8	-3.2	-2.7	0.6	0.7	-1.0	2.7	2.8
Leg fat percentage (right)	1.5	5.3	11.4	-1.1	1.3	1.5	-3.4	-3.2	1.3	1.6	-0.3	3.2	3.4
Arm fat-free mass (right)	0.0	0.2	1.0	-0.4	-0.0	-0.4	-0.5	-0.4	-0.1	-0.2	-0.5	0.5	1.0
Exposure to tobacco smoke outside home	1.0	1.3	3.7	-0.5	-0.4	-0.2	1.4	1.9	-0.1	-0.2	0.5	-1.8	-1.9
Comparative body size at age 10	0.1	0.2	1.2	0.2	0.3	-0.2	1.1	0.4	0.3	-0.0	0.4	-0.5	-0.3
Number of full brothers	0.8	1.0	2.7	1.6	-0.8	-0.7	1.3	0.9	-0.7	-0.6	-0.2	-1.3	-1.0
Worry too long after embarrassment	0.4	0.6	2.2	-1.5	-0.8	-0.9	-0.4	0.2	-1.1	-0.5	-0.9	0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	4.7	-2.2	1.3	1.0	1.2	1.7	1.0	1.3	2.1	-1.7	-1.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.7	0.8	0.8	-0.2	0.4	0.8	0.8	0.9	-0.3	-0.1
Number of children fathered	6.2	7.0	11.4	-0.8	3.1	3.0	-2.7	-2.4	3.1	3.4	2.1	2.8	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.0	0.1	-0.0	0.5	0.4	0.2	0.1	0.2	-0.5	-0.3
Age at first live birth	0.3	0.6	1.3	-1.1	-0.9	-0.8	0.6	0.4	-0.5	-0.6	-0.5	-1.0	-1.1
Pulse wave peak to peak time	0.2	0.2	0.5	-0.3	0.7	0.6	0.1	-0.2	0.4	0.7	0.5	0.3	0.6
Health satisfaction	0.3	0.5	2.0	-0.3	0.2	-0.1	1.4	1.2	-0.2	-0.4	0.5	-0.6	-0.3
Shortness of breath walking on level ground	0.8	0.9	2.5	-1.4	0.5	0.8	-0.8	-0.8	0.2	0.5	0.0	1.6	1.4
Qualifications: College or University degree	0.8	2.5	4.6	-0.2	1.2	0.9	1.8	2.0	1.6	1.2	2.1	-1.9	-2.0
Eye problems/disorders: None of the above	1.3	1.5	2.5	-1.0	-1.3	-1.5	1.0	1.1	-1.6	-1.6	-0.8	-1.1	-0.9
Mouth/teeth dental problems: Loose teeth	2.2	2.6	4.1	1.2	-1.9	-2.0	1.6	1.3	-1.9	-1.7	-1.3	-1.7	-1.4
Emphysema/chronic bronchitis	0.7	0.8	3.3	-0.9	-0.4	-0.3	0.9	1.8	-0.4	-0.3	0.3	-1.2	-1.0
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.7	0.7	0.5	0.2	0.3	0.8	0.9	1.0	0.0	-0.4
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.7	-0.0	0.1	-0.7	-0.5	-0.3	-0.4	-0.5	0.8	0.7
Medication: Blood pressure	1.2	2.0	3.9	-0.2	1.3	1.6	-1.7	-1.8	1.2	1.2	0.4	2.0	1.7
Angina (self-reported)	0.3	0.4	1.0	-0.9	-0.9	-0.7	-0.1	-0.1	-0.7	-0.4	-1.0	-0.3	-0.4
Migraine (self-reported)	1.0	1.2	5.2	2.3	-0.5	0.2	0.2	0.4	0.4	0.6	0.6	-1.7	-1.6
Medication: Ibuprofen	0.8	1.0	3.3	1.8	-0.6	-0.7	0.3	0.9	-0.1	-0.6	-0.1	-1.6	-1.3
Medication: Allopurinol	0.1	0.2	0.5	-0.3	0.6	0.3	0.2	-0.1	0.3	0.7	0.4	0.2	0.5
Medication: Omeprazole	0.8	0.9	2.3	-1.5	-0.4	-0.3	-0.8	-0.9	-1.0	-0.9	-1.0	1.1	1.2
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.6	0.7	0.4	-0.2	0.0	0.8	0.7	0.7	-0.3	-0.1
Mean time to correctly identify matches	2.4	4.5	10.6	-1.9	-1.3	-1.2	2.3	3.1	-1.0	-1.1	-0.1	-3.2	-3.3
Heart disease (mother)	0.4	0.5	1.1	-0.3	1.0	0.9	-0.6	-0.1	1.0	0.8	0.8	0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	-0.1	0.1	-0.2	0.2	0.3	-0.1	-0.7	0.3	0.2	-0.4
Whole body fat mass	0.5	2.3	6.3	-0.9	0.2	0.4	-2.5	-2.0	0.4	0.4	-1.0	2.1	2.3
Leg fat mass (right)	0.5	2.1	5.6	-0.9	0.5	0.5	-2.2	-2.0	0.6	0.6	-0.6	2.0	2.4
Arm predicted mass (right)	0.0	0.2	0.9	-0.3	0.1	-0.3	-0.4	-0.2	0.0	-0.1	-0.4	0.5	0.9
Pulse rate, automated reading	0.2	0.7	4.1	-2.0	-0.3	-0.3	0.5	0.9	-0.2	-0.3	0.0	-0.8	-0.8
Alcohol intake frequency.	2.5	5.8	9.8	-2.2	-3.1	-2.8	1.8	1.7	-2.8	-2.6	-2.3	-2.2	-2.2
Comparative height size at age 10	0.3	1.6	12.1	-3.5	-0.5	-0.5	-0.6	-0.5	-0.6	-0.3	-0.8	0.9	0.5
Number of full sisters	0.4	0.5	1.0	0.5	0.6	0.5	0.5	0.7	0.8	0.8	1.0	-0.8	-0.4
Suffer from ‘nerves’	0.8	1.3	2.5	-1.6	-1.0	-1.2	0.6	1.2	-1.4	-1.1	-0.5	-1.3	-1.2
Overall health rating	0.1	0.2	1.0	-0.3	0.6	0.4	-0.0	0.3	0.1	0.1	0.3	0.7	1.0
Chest pain or discomfort	0.4	0.5	2.0	-0.5	0.0	-0.4	0.7	1.4	0.5	-0.2	0.1	-1.1	-1.0
Had major operations	0.6	0.7	1.6	-1.3	-1.0	-1.1	-0.6	-0.1	-0.9	-1.1	-1.0	0.1	0.1
Age at last live birth	2.4	3.5	9.1	-1.6	-0.5	-0.7	2.5	2.5	-0.2	-0.2	0.8	-3.0	-3.0
Family relationship satisfaction	2.9	3.6	9.9	0.6	0.1	0.2	3.0	2.7	0.4	-0.1	1.4	-3.1	-2.8
Leg pain on walking	0.2	0.3	0.7	0.8	-0.2	0.0	-0.7	-0.7	-0.1	-0.5	-0.4	0.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.3	0.1	-0.2	0.6	0.2	-0.5	-0.6	-0.1	0.2	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.2	-0.6	-0.5	-0.6	-0.4	-0.3	-0.4	-0.9	0.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	-0.1	1.1	0.6	0.0	0.4	0.7	1.0	1.0	0.3	-0.0
Medication: Aspirin	0.1	0.2	0.8	0.9	0.5	0.5	-0.0	-0.2	0.4	0.5	0.3	-0.2	0.1
Supplements: Vitamin C	0.1	0.1	0.3	-0.3	0.6	0.1	-0.0	-0.0	0.2	0.1	0.3	0.3	0.3
Knee pain experienced in last month	0.9	1.5	3.3	0.4	-1.2	-1.0	-0.7	-1.2	-1.4	-1.4	-1.8	1.0	1.3
Hypertension (Self-reported)	2.0	5.7	11.8	-2.0	1.6	2.1	-3.1	-3.4	1.2	1.6	0.2	3.2	3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-1.0	-0.6	-0.5	-0.4	-0.7	-0.9	-0.8	-0.8	0.5	0.5
Illnesses of father: Heart disease	0.7	1.0	2.7	-0.5	1.3	1.4	-0.2	0.4	1.6	1.2	1.5	0.1	-0.0
Illnesses of siblings: Diabetes	1.1	1.3	3.0	-0.4	1.7	1.4	0.5	0.5	1.4	1.5	1.7	0.5	0.2
Smoking status: Previous	0.3	0.4	1.2	0.0	1.0	1.1	-0.7	-0.1	0.5	0.7	0.6	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.0	-0.4	-1.0	-0.6	-0.0	0.2	-0.7	-0.5	-0.8	-0.5	-0.4
Whole body fat-free mass	0.1	0.7	1.5	-1.1	-0.9	-1.2	0.6	0.7	-0.8	-1.0	-0.8	-0.7	0.0
Leg fat-free mass (right)	0.3	1.4	3.0	-0.6	-1.3	-1.7	1.1	1.2	-1.3	-1.5	-1.2	-1.0	-0.3
Arm fat percentage (left)	0.4	1.4	4.1	-0.2	0.1	0.4	-2.0	-1.7	0.3	0.4	-0.9	1.6	1.9
Average weekly red wine intake	0.5	0.7	2.8	0.3	0.7	0.5	-0.6	-0.9	0.5	0.4	0.2	1.4	1.7
Handedness (chirality/laterality): Left-handed	2.3	2.7	4.9	-1.4	-1.8	-2.2	1.4	1.6	-2.2	-2.2	-1.3	-1.1	-0.8
Mood swings	0.6	1.2	8.9	-3.0	0.1	0.0	1.1	0.9	-0.5	0.0	0.2	-0.3	0.3
Loneliness, isolation	0.5	0.6	1.3	0.7	-0.7	-0.6	0.7	1.0	-1.1	-0.9	-0.6	-0.9	-0.6
Long-standing illness, disability or infirmity	1.5	2.2	4.1	0.7	1.8	1.9	-1.2	-1.2	1.6	1.2	1.0	1.7	2.0
Ever had bowel cancer screening	0.5	0.6	1.9	-1.1	-0.1	-0.0	-1.1	-0.7	-0.3	-0.0	-0.5	1.4	0.7
Diabetes diagnosed by doctor	0.2	0.3	1.3	-1.2	0.5	0.6	-0.4	-0.2	0.2	0.4	0.3	0.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	0.1	0.6	0.5	0.5	1.1	0.3	0.4	1.0	-0.9	-0.3
Friendships satisfaction	2.3	2.9	5.3	0.9	0.8	1.1	2.3	2.1	1.0	1.1	1.9	-2.3	-2.3
Qualifications: nursing, teaching	1.2	1.9	5.2	0.4	1.8	1.9	-0.4	-0.8	2.3	1.5	1.8	0.8	0.3
Commuting to job workplace: Walk	1.9	2.1	4.2	-0.8	2.1	1.7	-0.4	-1.0	1.5	1.9	1.7	1.1	1.5
Eye problems/disorders: Cataract	2.8	3.3	6.0	1.3	2.5	2.2	-1.1	-1.2	2.2	2.2	1.6	1.7	1.6
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.4	-2.1	-1.6	-1.7	0.7	1.2	-1.8	-2.1	-1.1	-1.3	-1.1
Medication for cholesterol	1.5	2.3	4.7	1.7	-1.3	-1.3	1.5	2.0	-1.0	-1.0	-0.5	-2.2	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.6	7.8	0.8	-1.9	-2.3	1.9	1.8	-1.9	-2.8	-1.4	-1.7	-1.7
Back pain experienced in last month	0.3	0.4	2.0	1.4	-0.1	-0.2	-0.4	-0.5	-0.1	-0.6	-0.5	0.4	0.9
Mineral and other dietary supplements	0.3	0.4	1.5	0.1	-0.3	-0.3	0.5	0.7	-0.6	-0.6	-0.1	-1.2	-0.7
Breast cancer (self-reported)	0.4	0.4	2.5	-1.6	-0.2	-0.5	0.8	0.7	-0.2	-0.6	-0.1	-0.3	-0.3
Asthma (self-reported)	0.4	0.9	1.9	-0.5	0.8	1.0	-1.2	-0.3	1.3	1.4	1.1	-0.5	-0.5
Osteoporosis (self-reported)	0.6	0.7	1.9	-0.8	0.9	1.0	-0.4	-0.0	1.4	1.2	1.1	0.3	0.0
Osteoarthritis (self-reported)	0.2	0.2	0.5	-0.3	0.4	-0.2	0.6	0.5	-0.4	-0.5	0.0	0.7	0.7
Medication: Aspirin	0.2	0.2	0.6	0.8	0.5	0.6	-0.3	-0.2	0.5	0.5	0.3	-0.3	-0.0
Medication: Gliclazide	1.2	1.3	3.1	-0.9	-1.3	-1.5	0.5	0.8	-1.4	-1.8	-1.3	-0.8	-0.6
Illnesses of father: None of the above (group 1)	2.4	3.0	6.7	-0.2	-2.2	-2.2	-0.1	-0.8	-2.4	-2.6	-2.6	0.4	0.5
Smoking status: Current	0.9	1.4	4.4	0.8	0.4	0.3	1.6	1.8	0.5	0.1	1.1	-2.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.9	0.3	0.4	-0.2	-0.4	0.5	0.3	0.2	-0.1	-0.3
Whole body water mass	0.1	0.6	1.3	-0.9	-0.8	-1.1	0.6	0.7	-0.7	-0.9	-0.8	-0.6	0.0
Leg predicted mass (right)	0.3	1.5	3.1	-0.6	-1.4	-1.8	1.1	1.3	-1.3	-1.5	-1.2	-1.1	-0.3
Arm fat mass (left)	0.4	1.7	4.6	-0.7	0.2	0.4	-2.1	-1.8	0.4	0.5	-0.8	1.8	2.1
Number of self-reported non-cancer illnesses	1.1	1.8	5.2	-2.3	0.6	0.8	-1.6	-1.6	0.5	0.8	-0.1	1.9	1.6
Average weekly champagne plus white wine intake	0.1	0.2	1.1	-1.1	0.1	0.2	0.2	0.1	0.5	0.3	0.4	-0.3	-0.4
Miserableness	0.6	1.0	3.8	-1.9	0.8	0.7	0.9	1.2	0.5	0.5	1.2	-0.7	-0.4
Guilty feelings	1.2	1.8	3.6	-1.8	-1.4	-1.5	0.7	1.5	-1.9	-1.4	-1.1	-0.8	-0.5
Wears glasses or contact lenses	2.4	2.7	4.7	-2.2	1.8	1.8	-1.3	-1.3	1.6	1.6	1.4	1.6	1.8
Ever taken oral contraceptive pill	0.9	1.0	4.1	2.0	-0.6	-0.3	-0.5	-1.1	-0.7	-1.0	-1.1	0.6	1.1
Hearing aid user	0.1	0.1	0.3	0.4	0.3	0.5	-0.1	-0.2	0.3	0.5	0.3	0.3	0.1
Mother’s age at death	2.4	3.0	9.3	0.2	-0.6	-1.1	2.6	3.0	-0.4	-0.9	0.4	-2.2	-2.4
Financial situation satisfaction	1.4	1.8	3.5	1.9	-1.5	-1.1	1.1	1.1	-1.4	-1.3	-1.0	-1.4	-1.2
Tinnitus: Yes, now most or all of the time	2.1	2.5	4.4	-0.8	-1.7	-1.9	1.7	1.6	-2.0	-2.1	-1.3	-0.9	-0.9
Commuting to job workplace: Public transport	0.7	0.8	1.8	-0.7	-1.0	-1.3	0.9	0.4	-1.2	-1.2	-0.9	-0.6	-0.2
Eye problems/disorders: Glaucoma	0.8	1.0	2.6	0.4	-1.6	-1.3	0.6	-0.2	-1.1	-0.9	-1.4	-0.8	-0.8
Medication: Blood pressure	0.9	1.6	5.0	-2.2	0.7	0.8	-1.4	-1.5	0.4	0.7	-0.0	1.5	1.6
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.5	0.6	1.6	1.3	0.6	0.7	1.5	1.1	1.6	-0.1	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.3	-0.4	-0.4	-0.7	-0.9	-0.0	-0.3	-0.8	1.2	0.4
High cholesterol (Self-reported)	2.9	5.1	13.6	-1.4	0.9	1.1	-3.1	-3.3	0.5	1.0	-0.6	3.7	3.4
Medication: Bendroflumethiazide	2.0	3.0	4.4	-1.5	2.1	2.0	-1.6	-1.2	1.8	1.7	1.5	2.1	1.8
Medication: Paracetamol	0.1	0.2	0.5	-0.1	-0.5	-0.4	-0.7	-0.1	-0.6	-0.5	-0.7	0.2	0.5
Medication: Lisinopril	2.6	3.4	8.2	-0.8	0.5	1.0	-2.8	-2.6	0.2	0.7	-0.8	2.9	2.8
Medication: Atorvastatin	2.7	3.3	9.5	-1.7	0.7	0.6	-1.9	-2.7	0.0	0.3	-0.7	3.1	3.0
Illnesses of father: High blood pressure	0.4	0.5	1.1	1.0	0.8	0.8	0.3	0.6	0.8	0.9	1.0	-0.5	-0.3
Alcohol drinker status: Never	0.9	1.0	2.8	-1.3	-1.7	-1.3	0.1	-0.0	-1.3	-0.6	-1.2	-0.4	-0.8
Ever smoked	0.5	0.8	1.8	0.5	1.0	0.8	1.1	1.3	0.5	0.4	1.4	-1.0	-0.5
Basal metabolic rate	0.1	0.5	1.1	-1.0	-0.7	-1.0	0.2	0.3	-0.6	-0.8	-0.9	-0.2	0.4
Leg fat percentage (left)	1.6	5.7	13.0	-0.8	1.4	1.5	-3.6	-3.4	1.3	1.7	-0.4	3.4	3.5
Arm fat-free mass (left)	0.1	0.4	1.3	-1.1	-0.2	-0.4	-0.6	-0.5	-0.2	-0.3	-0.7	0.6	1.2
Number of operations (self-reported)	0.8	1.2	8.2	-2.9	-0.5	-0.3	-1.4	-1.0	-0.4	-0.1	-0.6	0.5	0.3
Average weekly beer plus cider intake	0.9	1.3	5.8	2.4	0.5	0.4	1.2	1.2	0.5	0.4	1.2	-1.1	-1.1
Irritability	0.5	0.9	3.4	-0.1	0.5	-0.1	1.8	1.8	0.1	-0.1	0.8	-1.0	-0.7
Risk taking	2.4	3.5	9.0	-0.5	1.0	0.6	2.0	2.4	1.4	0.6	2.2	-3.0	-2.7
Ever had prostate specific antigen (PSA) test	1.8	2.0	4.2	1.7	-1.9	-1.7	0.1	-0.4	-1.7	-1.9	-2.1	0.3	0.3
Fractured/broken bones in last 5 years	0.5	0.6	1.7	-0.2	1.2	0.9	0.2	-0.2	1.0	1.3	1.1	0.5	0.2
Age started oral contraceptive pill	1.9	2.4	4.4	0.2	2.1	1.9	-1.1	-1.1	1.9	1.5	1.4	1.7	1.7
Diastolic blood pressure, automated reading	1.6	4.9	13.7	-0.3	1.4	1.7	-3.0	-3.7	1.5	1.5	0.1	3.0	2.9
Ever depressed for a whole week	1.5	1.8	4.3	-1.0	-0.5	-0.6	2.1	2.1	-0.6	-0.8	0.3	-1.9	-1.8
Unable to work because of sickness or disability	0.6	0.8	3.4	1.8	-0.3	-0.4	1.1	1.0	-0.6	-0.6	-0.1	-1.1	-0.1
Commuting to job workplace: Cycle	0.9	1.1	2.0	-1.1	0.9	0.7	1.0	1.4	0.8	0.3	1.3	-1.4	-0.9
Myopia	3.5	5.1	8.6	-0.0	-2.8	-2.7	2.1	1.8	-2.5	-2.9	-1.9	-2.2	-2.2
Vascular/heart problems diagnosed by doctor	2.3	6.2	13.5	1.5	-1.6	-2.2	3.3	3.7	-1.3	-1.7	-0.1	-3.4	-3.3
Cholesterol lowering medication	1.3	2.0	5.2	-0.7	0.3	0.4	-1.9	-2.3	-0.1	0.4	-0.7	2.1	2.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-1.2	-0.5	-0.4	-0.3	-0.4	-1.0	-1.0	-0.9	0.8	0.8
Pain experienced in last month	1.0	1.6	4.8	-0.2	0.4	0.5	1.4	1.6	0.7	1.0	1.4	-1.8	-2.2
Supplements: Calcium	0.4	0.4	0.9	0.1	0.4	0.5	0.8	0.7	0.5	0.8	0.9	-0.5	-0.7
Basal cell carcinoma (self-reported)	1.5	1.7	3.5	-0.8	-0.9	-1.3	1.9	1.7	-1.0	-0.9	-0.3	-1.9	-1.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.9	0.2	0.4	-1.0	-0.8	0.5	0.4	-0.3	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	0.2	-1.3	-1.4	-0.1	0.5	-1.5	-1.2	-1.1	-0.5	-0.4
Heart disease (siblings)	0.6	0.8	2.3	-0.6	-0.0	0.4	-1.4	-1.3	0.2	0.7	-0.5	1.5	0.7
Alcohol drinker status: Previous	2.0	2.3	6.4	-0.9	-1.0	-0.9	1.6	2.1	-0.7	-0.9	-0.2	-2.3	-2.5
Pack years of smoking	0.1	0.1	0.3	0.3	-0.0	-0.2	-0.5	0.3	-0.4	-0.3	-0.3	0.3	0.5
Impedance of whole body	0.1	0.6	1.7	-1.1	0.3	0.8	-1.3	-0.9	0.3	0.7	0.2	1.0	0.3
Leg fat mass (left)	0.6	2.2	6.0	-0.7	0.5	0.5	-2.3	-2.1	0.5	0.6	-0.7	2.1	2.4
Arm predicted mass (left)	0.1	0.3	1.2	-1.1	0.0	-0.3	-0.4	-0.4	-0.0	-0.1	-0.4	0.4	0.9