TWAS hub - ACADS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0510	0.0260	1.6e-02	0.057	0.019	0.047	0.043	0.055	1.5e-07	1.8e-03	1.8e-06	5.0e-06	3.0e-07
2	GTEx	Artery Tibial	0.0889	0.0348	1.5e-03	0.013	NA	0.034	NA	0.041	3.1e-02	NA	1.0e-03	NA	3.6e-04
3	GTEx	Brain Cerebellum	0.4500	0.1060	4.3e-06	0.276	NA	0.276	NA	0.267	8.6e-09	NA	8.8e-09	NA	1.7e-08
4	GTEx	Brain Cortex	0.3980	0.1060	1.9e-04	0.097	NA	0.298	NA	0.209	1.3e-03	NA	6.3e-09	NA	1.9e-06
5	GTEx	Esophagus Muscularis	0.1130	0.0470	3.1e-03	0.041	NA	0.040	NA	0.027	1.6e-03	NA	1.7e-03	NA	8.6e-03
6	GTEx	Muscle Skeletal	0.0865	0.0327	4.3e-04	0.020	NA	0.020	NA	0.023	4.3e-03	NA	4.1e-03	NA	2.4e-03
7	GTEx	Nerve Tibial	0.1389	0.0436	1.1e-05	0.103	NA	0.083	NA	0.083	9.4e-08	NA	1.7e-06	NA	1.8e-06
8	GTEx	Testis	0.1710	0.0570	1.8e-04	0.127	NA	0.074	NA	0.100	2.9e-06	NA	3.4e-04	NA	3.5e-05
9	GTEx	Thyroid	0.2890	0.0510	0.0e+00	0.292	NA	0.302	NA	0.329	1.4e-22	NA	1.9e-23	NA	8.1e-26
10	YFS	Blood	0.0478	0.0148	2.1e-07	0.032	0.030	0.029	0.030	0.029	1.0e-10	3.3e-10	7.6e-10	3.1e-10	9.0e-10
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0509	0.0249	2.3e-03	0.012	0.035	0.034	NA	0.024	1.5e-02	7.4e-05	1.0e-04	NA	9.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Blood Red Count	18.3	176.3	292.8	17.1	16.0	15.9	12.3	16.3	-10.4	16.5	10.4	3.1	-15.0	1.6
Lung FVC	6.8	34.6	60.2	7.8	5.2	6.3	5.5	6.2	-6.5	6.1	6.2	3.1	-7.6	0.4
Asthma	5.5	10.8	25.4	-2.3	-2.7	-4.4	-2.9	-3.2	3.8	-3.1	-2.5	-5.0	1.8	3.1
Allergy or Eczema	5.1	13.5	50.7	-2.4	-0.8	-2.9	-2.3	-3.4	5.8	-1.4	-4.3	-7.1	3.0	1.8
Asthma (self-reported)	4.8	9.5	23.4	-2.1	-2.3	-4.1	-2.6	-3.1	3.6	-2.8	-2.4	-4.8	1.7	2.9
Medication: Ventolin 100micrograms inhaler	4.4	5.7	14.5	-2.2	-1.6	-3.8	-3.0	-2.5	2.6	-1.7	-1.6	-2.8	1.7	1.4
Emphysema/chronic bronchitis	4.1	4.6	7.9	1.8	2.7	2.3	1.4	2.2	-2.8	2.4	2.3	1.9	-1.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.1	8.6	20.0	3.3	1.6	2.5	2.1	3.2	-4.5	2.4	3.9	2.7	-3.4	-0.9
Diabetes (father)	4.0	5.0	8.6	-2.9	-2.9	-2.3	-2.4	-2.4	2.2	-2.6	-2.0	-1.8	1.3	1.0
Number of operations (self-reported)	4.0	6.0	15.3	1.6	2.3	1.9	1.2	1.9	-2.6	2.1	2.4	3.9	-1.9	-3.7
Allergy	3.8	8.7	20.2	2.2	0.5	3.2	2.5	2.9	-4.4	1.2	3.6	4.5	-3.5	0.0
Noisy workplace	3.6	4.5	10.4	2.1	2.3	1.7	0.7	1.7	-2.8	2.1	3.2	1.3	-2.0	-2.2
Gout (self-reported)	3.3	4.5	7.2	1.9	2.1	2.7	2.7	2.3	-1.9	2.4	1.9	2.3	-1.5	-1.2
Hayfever, allergic rhinitis or eczema	3.2	7.1	22.4	-1.8	-0.2	-2.5	-1.5	-2.1	4.2	-0.4	-3.4	-4.7	2.9	0.5
Severe depression (siblings)	3.1	3.5	8.4	-1.8	-2.7	-1.9	-2.9	-1.8	0.2	-2.2	-0.6	1.7	1.9	-1.0
Blood Eosinophil Count	3.0	22.9	68.7	-2.8	-4.2	-3.7	-4.2	-4.0	5.7	-4.6	-3.8	-8.3	1.8	6.2
Supplements: Zinc	3.0	3.3	5.3	1.6	2.2	2.0	1.9	1.1	-2.3	1.6	2.3	1.7	-1.0	-1.7
Smoking status: Previous	3.0	4.5	9.4	2.4	2.4	1.4	1.6	2.0	-2.4	2.4	3.1	0.6	-2.4	-1.5
Respiratory disease	2.9	6.5	19.1	-1.6	-1.5	-3.1	-1.6	-2.7	3.3	-2.4	-2.3	-4.4	1.5	2.2
Diabetes (mother)	2.9	3.7	9.5	1.3	2.1	1.8	2.3	1.2	-2.1	0.9	0.9	2.3	-1.8	-3.1
Commuting to job workplace: Public transport	2.9	3.5	6.1	-2.1	-1.7	-2.2	-1.4	-2.2	1.9	-2.2	-2.5	0.3	2.0	-0.6
Relative age of first facial hair	2.8	5.7	17.8	-2.4	-0.2	-1.4	-2.0	-2.8	3.5	-0.7	-2.7	-4.2	2.1	0.6
Pulse rate	2.8	4.8	8.8	-1.9	-1.8	-2.1	-0.9	-1.9	2.8	-2.2	-3.0	-2.9	1.4	2.3
Depression (self-reported)	2.6	3.1	8.1	1.3	1.4	1.1	1.1	0.7	-2.2	1.3	2.7	2.9	-0.8	-2.3
Age at First Birth	2.5	3.6	6.6	-1.4	-2.0	-2.2	-1.9	-2.0	2.4	-1.8	-1.7	-2.6	0.8	1.5
Past tobacco smoking	2.5	4.5	12.8	-2.4	-2.1	-1.7	-1.2	-1.7	2.8	-1.9	-3.6	-1.0	2.3	1.2
Number of children fathered	2.5	2.8	6.6	2.1	0.4	1.6	0.1	2.0	-0.8	1.7	1.3	-2.0	-2.6	2.1
Medication for pain relief, constipation, heartburn	2.5	4.2	6.7	-2.1	-2.2	-0.6	-2.1	-2.4	2.6	-2.4	-2.4	-1.5	2.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	12.8	-1.6	-2.4	-2.5	-1.8	-2.4	3.2	-1.9	-2.0	-3.6	0.6	1.6
Smoking Status	2.4	5.7	18.7	2.0	1.0	1.0	1.2	1.3	-4.2	0.9	4.3	3.1	-2.0	-1.8
Happiness	2.4	2.9	6.5	-1.9	-0.8	-1.2	-1.4	-2.3	2.1	-2.0	-2.6	-0.2	1.9	-0.1
Hypothyroidism (self reported)	2.3	5.2	9.1	-2.3	-1.6	-2.2	-3.0	-2.8	2.3	-1.9	-1.3	-3.0	2.9	0.3
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	14.7	-0.4	1.1	0.4	0.9	-0.1	-1.6	0.8	1.5	2.7	0.6	-3.8
Osteoporosis (self-reported)	2.3	2.9	6.2	1.7	1.3	0.7	0.6	2.2	-2.3	1.0	2.2	2.5	-2.2	-0.5
Schizophrenia (2018)	2.2	4.6	13.9	1.4	1.0	1.5	1.2	1.6	-3.5	1.4	3.7	2.5	-2.2	-1.4
Mean Putamen Volume	2.2	2.5	7.5	-1.7	-2.7	-2.3	-1.0	-1.0	1.2	-2.2	-1.7	-0.3	1.0	0.3
Number of incorrect matches in round	2.2	3.6	6.1	2.4	1.8	1.6	0.8	2.2	-1.9	2.3	2.5	1.0	-2.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	6.9	20.4	3.9	1.7	2.2	2.2	2.8	-2.4	2.1	2.6	-0.3	-4.5	1.7
Number of full brothers	2.2	2.7	6.3	2.5	1.0	1.2	1.2	2.1	-2.0	1.6	1.6	0.5	-2.4	-0.4
Mean time to correctly identify matches	2.2	4.1	9.7	1.3	1.9	2.2	0.7	1.1	-2.9	1.6	3.1	3.1	-0.6	-1.7
Family relationship satisfaction	2.2	2.7	6.4	-2.0	-0.8	-1.0	-1.4	-1.9	1.9	-1.7	-2.4	0.0	2.5	-0.6
Coronary Artery Disease (CAD)	2.1	2.5	5.3	1.3	0.9	2.2	0.8	2.2	-2.3	1.2	1.5	2.0	-1.1	-0.8
Forced vital capacity (FVC), Best measure	2.1	7.7	22.7	4.1	1.7	2.3	2.5	2.6	-2.3	1.8	3.1	-0.9	-4.8	2.2
Osteoarthritis (self-reported)	2.1	2.7	5.3	1.8	1.8	1.5	0.5	1.6	-2.0	2.0	2.3	1.7	-1.5	-0.7
Schizophrenia (2014)	2.0	4.4	9.8	1.3	1.7	1.7	1.4	2.2	-3.1	2.0	3.0	2.7	-1.5	-1.6
Bipolar Disorder or Schizophrenia	1.9	4.7	14.3	0.5	1.0	1.1	1.5	0.5	-3.4	0.8	3.6	3.8	-0.4	-2.8
Bipolar Disorder (2011)	1.9	1.8	6.8	-1.0	-0.5	-0.6	0.3	-1.2	-1.1	-0.7	0.9	2.0	2.0	-2.6
Type 2 Diabetes (T2D) (2012)	1.9	2.2	9.3	-0.2	0.2	0.2	-0.4	0.8	-2.0	0.2	0.8	3.1	0.4	-3.0
Age when periods started (menarche)	1.9	4.5	16.0	-1.8	-1.5	-0.4	-0.4	-2.5	2.8	-1.7	-1.4	-4.0	0.7	2.9
Health satisfaction	1.9	2.5	6.2	-1.6	-2.0	-1.0	-1.4	-1.5	1.6	-2.5	-1.5	-1.6	1.2	0.9
Back pain experienced in last month	1.9	2.8	7.6	1.4	1.0	1.2	1.5	1.3	-2.8	0.8	2.7	1.7	-2.0	-0.4
Myopia	1.9	2.8	4.4	-1.5	-1.5	-1.3	-1.9	-1.9	1.8	-1.9	-2.1	-2.0	1.6	0.5
Intelligence (Savage-Jansen 2018)	1.8	5.6	16.1	-2.1	-1.5	-1.5	-0.0	-4.0	3.0	-2.1	-2.5	-2.3	3.3	-0.2
Primary Biliary Cirrhosis	1.8	2.6	9.0	0.4	0.8	0.9	2.3	0.9	-2.3	1.1	1.6	3.0	-0.0	-1.4
Type 2 Diabetes (T2D) (2018)	1.8	3.4	9.3	-2.2	-1.5	-1.0	-0.4	-1.9	-0.2	-2.5	-1.2	2.2	1.9	-3.0
Had other major operations	1.8	2.2	7.1	1.2	0.9	1.0	1.1	1.9	-1.9	1.2	1.2	2.7	-0.5	-1.6
Diabetes (self-reported)	1.8	2.8	5.4	-2.2	-1.6	-1.2	-0.2	-2.1	0.9	-2.3	-1.9	0.4	1.4	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	6.6	-1.7	-2.2	-2.6	-1.5	-1.4	-0.1	-1.7	0.5	-0.3	0.8	-0.6
HbA1C	1.7	1.9	13.3	0.2	1.5	0.7	0.3	-0.1	-1.2	0.9	0.5	1.4	-0.2	-3.6
Blood White Count	1.7	12.3	30.8	-2.3	-3.5	-3.3	-2.9	-2.3	4.3	-3.5	-3.0	-4.5	1.5	5.5
Ever used hormone-replacement therapy (HRT)	1.7	2.1	5.5	1.6	2.3	0.8	0.4	2.0	-0.5	2.2	1.2	-0.3	-1.5	1.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.6	-2.1	-1.4	-0.3	-1.2	-1.6	0.7	-1.8	-0.7	0.6	1.8	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.7	-1.9	-2.0	-1.8	-2.2	-1.1	-0.0	-1.3	0.0	1.5	1.9	-0.7
Nervous feelings	1.7	3.2	6.2	-2.0	-0.8	-1.7	-2.1	-1.6	2.5	-1.2	-2.4	-1.3	2.4	-0.2
Heart attack	1.7	2.2	4.4	1.8	1.3	1.1	-0.2	2.0	-2.0	1.4	2.1	1.0	-1.7	0.0
Alcohol intake versus 10 years previously	1.7	2.5	9.1	1.4	0.4	1.3	0.3	0.5	-2.6	-0.1	3.0	2.2	-1.7	-0.1
Number of live births	1.7	2.4	4.4	-1.5	-1.6	-1.5	-1.7	-1.5	1.2	-1.5	-1.1	-1.5	2.1	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	10.8	0.1	0.1	-0.5	-0.5	0.0	-2.9	0.1	3.3	2.8	0.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.1	-1.7	-0.8	-1.2	-1.5	-1.7	-0.9	-1.4	1.0	2.0	1.5	-2.0
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.4	1.3	1.4	2.0	0.7	1.4	-1.0	1.9	2.1	-0.5	-1.2	0.7
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.7	1.4	0.8	1.0	1.3	0.7	-1.8	1.3	1.9	1.3	-1.5	-0.9
Fluid intelligence score	1.6	3.3	6.0	-1.9	-1.4	-1.4	-0.4	-2.4	2.4	-2.0	-2.1	-1.7	2.3	0.3
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	16.1	3.3	1.2	1.5	1.7	2.8	-2.2	2.0	2.6	-0.5	-4.0	1.8
Eye problems/disorders: None of the above	1.6	1.8	3.0	1.7	1.4	0.8	1.3	1.0	-1.5	1.4	1.2	1.4	-1.5	-1.2
Diabetes diagnosed by doctor	1.6	2.7	6.1	-2.1	-1.6	-1.1	-0.3	-1.9	0.6	-2.5	-1.7	1.0	1.2	-2.4
Medication: Paracetamol	1.6	2.4	4.3	1.5	1.7	-0.2	1.7	2.1	-1.7	2.0	1.4	1.8	-1.4	-0.4
Ever smoked	1.6	2.9	7.8	1.8	1.8	1.5	1.3	1.3	-2.4	1.8	2.8	0.7	-1.6	-0.7
Bipolar Disorder (2018)	1.5	2.3	8.3	-1.0	0.3	-0.2	0.9	-1.2	-1.0	-0.5	1.1	2.9	2.1	-2.6
Verbal and Numeric Reasoning (VNR)	1.5	3.6	7.7	-1.9	-1.3	-2.0	-0.4	-2.8	2.3	-1.9	-1.5	-1.8	2.8	-0.5
Rheumatoid Arthritis	1.5	2.0	11.6	0.5	-1.6	-0.9	-1.9	0.2	0.5	-0.8	0.1	-1.7	-0.4	3.4
Medication: Co-codamol	1.5	1.8	6.3	0.2	0.6	0.7	-0.2	1.1	-1.9	0.6	1.4	2.5	-0.0	-2.2
Relative age voice broke	1.5	2.3	11.3	-1.2	0.1	-1.0	-0.4	-1.5	2.4	-0.2	-1.4	-3.4	0.5	1.3
Forced vital capacity (FVC)	1.5	5.9	17.6	3.4	1.3	1.6	1.8	2.5	-2.1	1.6	2.9	-0.9	-4.2	2.1
Illnesses of mother	1.5	1.9	3.9	-1.2	-2.0	-1.9	-1.4	-1.0	0.7	-1.4	-0.5	-1.5	0.4	2.0
Pulse wave Arterial Stiffness index	1.5	1.7	6.5	-1.7	-0.1	-0.8	-0.9	-1.6	1.6	-0.6	-1.5	-0.5	2.5	-0.6
Medication: Paracetamol	1.5	2.4	5.1	1.3	1.7	-0.2	1.5	1.8	-2.0	1.8	1.3	2.3	-1.2	-1.2
Loneliness, isolation	1.5	2.1	5.8	-1.4	-0.7	-1.0	-2.4	-1.0	-1.2	-0.6	1.6	1.3	1.3	-2.1
Depression (Nagel 2018)	1.4	2.2	5.9	-1.3	-1.1	-1.2	-2.0	-0.5	-1.2	-0.8	0.8	2.4	1.5	-2.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	6.5	-1.6	-0.8	-1.4	-2.2	-2.1	1.9	-1.0	-1.4	-1.8	2.5	-0.5
High cholesterol (Self-reported)	1.4	2.4	14.2	0.3	0.3	0.8	1.2	1.1	-2.1	0.7	1.7	3.8	-0.1	-1.2
Systolic Blood Pressure	1.3	6.3	17.5	-2.9	-1.4	-1.1	-1.0	-2.4	4.2	-1.7	-3.8	-2.6	3.0	0.9
Frequency of depressed mood in last 2 weeks	1.3	1.8	9.0	-0.3	0.1	-0.6	-0.6	0.5	-1.4	0.0	0.8	3.0	0.9	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.2	-2.2	-1.2	-0.7	-1.7	-1.3	0.3	-1.1	-0.5	1.3	2.3	-1.6
Financial difficulties in last 2 years	1.3	1.8	5.9	-1.0	-1.1	-0.8	-1.5	-0.4	-0.9	-0.9	0.3	2.4	1.4	-2.2
Standing height	1.3	12.6	39.7	-2.6	-3.2	-3.3	-3.4	-2.2	4.7	-2.9	-2.4	-6.3	1.8	4.0
Chest pain or discomfort	1.3	1.8	4.6	0.8	1.0	1.2	-0.1	0.7	-1.9	0.8	2.1	1.8	-1.2	-1.6
Leg pain on walking	1.3	1.6	2.9	-1.5	-1.7	-1.1	-1.3	-1.2	1.1	-1.6	-0.6	-0.7	1.6	0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	5.3	-1.1	0.3	-1.0	-0.6	0.3	-1.5	0.4	1.4	2.3	0.6	-2.2
Ever depressed for a whole week	1.3	1.6	4.9	-1.2	0.4	-0.3	1.5	-0.8	-0.7	-0.1	0.6	2.1	1.6	-2.2
Schizophrenia vs Biploar Disorder	1.2	1.6	4.6	1.4	0.7	0.5	-0.8	2.1	-1.4	1.3	1.0	-0.2	-1.8	1.1
Major Depression (MDD)	1.2	1.5	7.0	-1.0	0.5	0.2	1.0	-1.4	-0.2	-0.0	0.2	1.3	1.9	-2.6
Height	1.2	23.1	95.8	-3.0	-4.0	-3.5	-5.1	-1.6	5.0	-3.4	-1.8	-9.8	1.2	7.1
Pulse wave peak to peak time	1.2	1.5	6.1	1.6	-0.0	0.7	0.7	1.5	-1.3	0.4	1.3	0.0	-2.5	0.8
Medication: Allopurinol	1.2	1.6	4.1	1.1	1.2	1.9	2.0	1.6	-0.7	1.4	0.8	0.8	-0.7	-0.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	5.6	0.9	0.9	0.6	0.2	1.0	0.2	1.4	0.6	-2.4	-1.7	1.5
Qualifications: nursing, teaching	1.2	1.9	3.8	1.2	0.9	1.6	1.9	1.1	-1.4	1.2	2.0	1.1	-1.5	-0.6
Tinnitus: Yes, now most or all of the time	1.2	1.4	6.5	0.2	-1.2	-0.3	-1.8	0.3	0.7	-1.0	-0.7	-1.5	-0.4	2.5
Alcohol drinker status: Previous	1.2	1.4	8.0	0.7	0.6	0.9	0.5	0.7	-1.2	0.7	0.5	2.8	0.4	-1.5
Reaction Time	1.1	2.0	6.8	0.6	0.7	1.5	0.6	0.4	-2.3	0.3	2.3	2.6	-0.2	-1.0
HDL Cholesterol	1.1	1.8	6.0	1.1	1.2	2.0	2.4	1.1	-0.8	1.2	0.6	1.8	-0.2	-0.6
Blood Platelet Count	1.1	12.6	53.4	-1.6	-2.9	-0.6	-0.9	-3.1	4.0	-3.0	-2.6	-7.3	-1.4	5.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.9	0.4	1.8	1.3	2.0	0.2	-0.7	0.8	0.9	1.0	-0.5	-1.8
Maternal smoking around birth	1.1	1.6	5.1	-0.9	-1.6	-1.4	-2.2	0.1	0.4	-0.8	-0.1	-1.2	0.2	2.3
Qualifications: CSEs or equivalent	1.1	1.5	6.1	-1.1	-1.3	-2.5	-2.2	-0.5	-0.0	-0.3	-0.0	0.6	1.2	-0.5
Qualifications: None of the above	1.1	2.4	5.7	1.7	0.8	0.5	-0.6	1.9	-2.4	1.3	2.2	1.3	-2.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.9	-1.6	-1.6	-1.4	-1.7	-1.0	0.1	-1.7	-0.6	1.4	1.6	-1.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.7	3.5	1.9	1.8	1.2	1.2	1.3	-0.6	1.6	0.5	-1.7	-1.4	0.2
Medication: Aspirin	1.1	1.5	2.6	1.1	1.6	1.0	0.7	1.2	-1.4	1.2	1.2	1.5	-0.4	-1.6
Crohns Disease (2012)	1.0	1.6	4.7	1.1	1.1	1.3	0.5	1.5	-1.7	1.2	2.2	0.9	-0.9	-0.6
Leg fat-free mass (left)	1.0	5.3	17.0	-1.8	-2.2	-2.3	-1.8	-1.6	3.2	-1.8	-1.7	-4.1	1.1	2.1
Medication: Atenolol	1.0	1.2	5.8	-0.1	0.1	1.3	0.7	1.1	-1.5	0.2	0.9	2.4	-0.0	-1.2
Medication: Levothyroxine sodium	1.0	1.8	3.6	-1.2	-0.9	-1.1	-1.1	-1.2	1.9	-1.1	-1.8	-1.7	1.6	0.5
Leg predicted mass (left)	1.0	5.5	17.3	-1.8	-2.2	-2.3	-1.9	-1.6	3.3	-1.9	-1.8	-4.2	1.1	2.1
Illnesses of siblings	1.0	1.3	3.2	-1.3	0.7	-0.2	0.8	-1.3	1.8	0.4	-1.5	-1.6	1.5	-0.1
Trunk fat-free mass	1.0	5.6	17.6	-1.9	-2.1	-1.7	-0.9	-1.7	3.8	-1.9	-2.5	-4.2	1.2	2.0
Worrier / anxious feelings	1.0	1.9	5.0	1.0	1.4	0.4	-0.4	1.9	-1.5	1.9	1.8	2.2	-0.2	-0.2
Prospective memory result	1.0	1.2	4.0	-0.9	-1.7	-2.0	-1.6	-0.6	0.5	-1.2	-0.6	0.4	0.8	0.3
Lung cancer (father)	1.0	1.2	2.6	0.7	1.3	0.8	0.1	1.5	-1.6	1.2	1.1	1.3	-0.0	-0.9
Trunk predicted mass	1.0	5.7	17.5	-2.0	-2.0	-1.8	-0.9	-1.8	3.8	-2.0	-2.5	-4.2	1.3	1.9
Loud music exposure frequency	1.0	1.1	5.4	1.0	1.2	1.2	2.3	0.9	0.3	0.4	-0.5	0.4	-1.0	0.5
Neck or shoulder pain in last month	1.0	1.4	5.7	-0.4	0.8	-0.3	0.3	0.6	-1.7	0.4	1.5	2.4	0.1	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.5	0.8	1.0	-0.2	0.3	1.4	-1.6	1.9	1.2	1.1	-0.4	-0.8
Whole body fat-free mass	1.0	5.6	18.0	-1.8	-2.2	-2.0	-1.3	-1.7	3.5	-1.9	-2.1	-4.2	1.1	2.2
Friendships satisfaction	1.0	1.2	3.8	-1.6	-0.8	-0.6	-0.1	-1.6	0.8	-1.1	-1.1	0.5	1.9	-0.2
Whole body water mass	1.0	5.5	17.4	-1.8	-2.2	-2.0	-1.3	-1.7	3.6	-1.9	-2.1	-4.2	1.1	2.2
Leg predicted mass (right)	1.0	5.3	16.6	-1.7	-2.0	-2.4	-1.9	-1.5	3.2	-1.7	-1.8	-4.1	1.1	2.1
Medication: Atorvastatin	1.0	1.2	2.8	-1.6	-1.2	-1.0	-1.3	-1.0	-0.3	-0.8	0.4	1.2	1.7	-0.7
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.0	-0.8	-0.1	-0.6	-0.4	-0.7	0.6	-0.6	-1.4	1.2	2.0	-1.9
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.4	1.5	1.1	0.7	-0.5	1.6	-1.4	1.0	1.4	0.6	-1.3	0.1
Systolic blood pressure, automated reading	0.9	2.7	9.1	-1.4	-0.0	-0.3	-0.6	-0.5	3.0	-0.1	-2.3	-2.8	1.2	1.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.4	-1.1	-0.6	-0.9	-0.6	-1.6	0.0	-1.2	-0.2	1.4	1.1	-1.5
Blood clot in the leg (DVT)	0.9	1.2	6.8	-0.1	-1.0	-0.8	-2.6	-0.3	-0.8	-0.8	1.2	0.9	0.8	-0.3
Age at first live birth	0.9	1.6	3.5	-1.2	-0.8	-0.2	-0.3	-1.4	1.9	-1.6	-1.7	-1.9	0.7	-0.3
Qualifications: College or University degree	0.9	2.8	6.4	-1.8	-0.7	-0.6	1.2	-2.5	2.4	-1.5	-2.3	-1.0	2.1	-0.5
Medication: Blood pressure	0.9	1.5	3.1	-1.8	-1.5	-0.7	-0.7	-1.2	0.6	-1.5	-0.7	1.6	1.5	-0.8
Had major operations	0.9	1.1	3.7	0.5	0.0	0.0	0.1	0.7	-1.2	-0.1	0.8	1.9	-1.4	-1.7
Leg fat-free mass (right)	0.9	5.1	16.2	-1.7	-2.0	-2.4	-1.8	-1.5	3.2	-1.7	-1.7	-4.0	1.1	2.1
Mineral and other dietary supplements	0.9	1.2	2.5	-0.8	-1.0	-1.6	-1.0	-0.3	0.9	-1.5	-1.4	-1.5	0.5	-0.1
Medication: Aspirin	0.9	1.1	2.2	1.0	1.4	0.9	0.4	1.2	-1.1	1.2	1.0	1.1	-0.3	-1.5
Medication: Gliclazide	0.9	1.0	2.9	-1.3	-0.5	-1.1	0.0	-1.7	0.5	-0.9	-1.2	-0.5	0.4	-1.5
Hearing aid user	0.9	1.1	3.9	0.9	0.7	0.2	0.7	0.6	-1.3	0.2	1.8	0.8	-2.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.7	0.4	1.4	-0.1	1.1	1.3	-1.1	1.6	1.3	0.7	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	5.6	-0.2	-0.8	-0.5	-2.4	-0.4	-0.9	-0.8	1.2	1.2	0.9	-0.6
LDL Cholesterol	0.8	1.2	5.5	-0.7	0.1	1.4	0.4	0.5	-0.8	-0.3	0.3	2.3	1.4	-1.6
Lupus	0.8	1.2	3.4	-1.3	-0.8	-0.8	-0.3	-1.1	0.1	-0.6	-0.5	1.8	1.5	-1.5
Medication: Metformin	0.8	1.1	4.5	-1.1	-1.4	-1.4	-0.2	-1.4	0.0	-2.1	-0.8	-0.2	0.3	-0.2
Average weekly fortified wine intake	0.8	0.9	2.3	-0.8	-0.9	-1.3	-0.4	-0.4	1.1	-1.1	-1.0	0.2	1.5	1.0
Supplements: Glucosamine	0.8	1.1	4.0	0.9	1.7	1.3	1.0	0.5	-0.3	2.0	0.7	0.5	-0.2	-0.4
Mouth/teeth dental problems: Dentures	0.8	1.3	3.5	-1.9	-0.5	-0.7	-0.3	-1.3	0.2	-0.6	-0.5	1.7	1.7	-1.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.7	-0.7	-0.7	-0.4	0.3	-1.1	2.1	-0.9	-2.2	-1.1	0.8	0.1
Comparative body size at age 10	0.8	2.1	6.2	1.5	0.6	0.5	1.0	1.4	-2.0	0.5	1.1	2.5	-1.5	-1.9
Shortness of breath walking on level ground	0.8	1.0	1.6	-0.8	-1.0	-1.0	-0.7	-1.0	1.2	-1.1	-0.5	-1.3	0.8	1.3
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.0	-1.1	-1.1	-0.1	-0.8	-1.3	1.0	-1.4	-1.0	-0.9	0.6	0.4
Overall health rating	0.8	1.7	3.9	-2.0	-1.4	-1.3	-2.0	-1.0	-0.2	-1.4	0.2	0.6	1.9	-1.0
Breast cancer (self-reported)	0.8	0.9	2.4	-1.6	-0.6	-1.0	-0.3	-1.1	0.9	-1.2	-1.0	-0.7	1.0	-0.3
Basal metabolic rate	0.8	4.6	15.8	-1.7	-2.0	-1.9	-1.3	-1.4	3.2	-1.7	-1.7	-4.0	1.1	2.0
Cholesterol lowering medication	0.8	1.2	4.6	0.2	1.0	0.8	1.3	1.0	-0.9	1.1	0.3	2.1	0.5	-1.3
Ovarian Cancer	0.7	0.9	2.1	0.8	0.6	-0.3	-1.1	1.3	-1.5	0.9	1.1	1.3	-0.5	0.3
Current tobacco smoking	0.7	1.1	2.8	-1.0	-1.7	-0.6	-1.1	-1.3	-0.7	-1.6	0.4	1.1	0.8	-0.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	1.0	1.2	0.3	1.0	1.3	-0.2	1.2	0.1	0.1	-1.4	0.5
Stomach or abdominal pain in last month	0.7	0.9	2.4	0.3	0.5	-0.6	-0.2	0.6	-1.3	0.3	1.5	1.5	-0.3	-1.4
Medication: Simvastatin	0.7	1.0	4.6	0.5	0.7	1.1	0.9	0.4	-1.0	0.7	0.7	2.1	-0.4	-1.2
Father’s age at death	0.7	1.0	4.0	0.9	0.6	1.2	0.8	0.5	0.4	0.8	-0.0	-2.0	-0.5	1.4
Medication: Lansoprazole	0.7	0.8	2.7	0.1	0.6	0.2	0.2	0.9	-1.2	0.8	1.1	1.7	-0.7	-0.7
Length of working week for main job	0.7	0.8	2.8	-0.7	-0.4	-0.8	0.5	-0.8	1.6	-0.6	-1.7	-0.8	0.4	0.1
Average weekly red wine intake	0.7	1.0	3.6	-1.4	-0.6	0.1	-0.4	-1.2	0.6	-1.0	-0.4	-0.7	1.9	-1.1
Long-standing illness, disability or infirmity	0.7	1.1	2.7	1.0	1.4	1.4	1.6	1.1	-0.4	1.0	0.7	0.2	-1.1	-0.7
Eye problems/disorders: Cataract	0.7	0.8	2.5	-0.5	-1.6	-0.6	-0.7	-0.3	0.7	-1.5	-0.3	-0.7	-0.1	1.5
Illnesses of father: High blood pressure	0.7	0.8	3.1	1.2	0.8	0.7	0.4	0.9	0.1	1.1	-0.4	0.3	-0.9	-1.8
Commuting to job workplace: Cycle	0.7	0.8	2.7	-1.2	0.3	-0.7	1.6	-0.8	0.5	-0.4	-0.8	0.1	1.1	-1.1
Fasting Glucose	0.6	0.7	2.2	-1.5	-1.0	0.0	0.2	-1.5	0.3	-0.7	0.1	-0.1	1.2	-0.6
Cardiovascular Disease	0.6	1.8	7.5	-1.2	0.7	0.2	1.4	-0.2	0.1	0.3	-0.5	2.7	1.9	-2.2
Neuroticism	0.6	1.4	5.6	-1.3	-0.3	-1.4	-2.4	-0.4	-0.3	-0.2	0.9	1.4	1.6	-0.3
Average weekly spirits intake	0.6	0.8	2.0	-0.6	-1.0	-1.1	0.5	-1.0	1.4	-1.0	-0.9	-0.5	0.6	0.7
Townsend deprivation index at recruitment	0.6	0.9	2.5	1.0	0.8	0.6	1.1	0.8	-1.6	0.6	1.2	1.1	-0.7	-0.1
Taking other prescription medications	0.6	0.9	3.7	-0.6	0.6	-0.9	-0.3	-0.8	-0.6	-0.3	0.9	0.8	1.3	-1.9
Alcohol usually taken with meals	0.6	1.0	4.4	0.6	0.3	0.8	0.7	0.0	1.4	-0.1	-0.9	-2.1	-0.2	1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.2	0.0	0.8	0.6	-0.2	0.2	1.7	0.4	-1.1	-1.8	0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.6	-0.2	-0.0	0.0	0.3	-1.5	2.1	-1.4	-2.1	-0.7	0.8	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.4	-0.3	-0.5	-0.8	0.2	-1.3	0.2	-0.9	-0.3	1.6	0.7	-1.0
Alcohol intake frequency.	0.6	1.3	6.5	0.8	0.3	0.2	-1.2	0.6	-1.4	-0.3	1.3	2.6	-1.2	-0.6
Number of full sisters	0.6	0.7	2.2	1.3	0.7	1.1	0.4	0.2	-0.6	0.1	1.1	-0.5	-1.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	0.6	-0.3	-0.1	-0.7	0.8	-0.2	-0.3	1.0	-1.4	-1.4	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.3	-0.4	-1.5	-0.9	-1.1	-0.2	0.2	-1.4	-0.2	-0.1	0.3	1.3
Smoking status: Current	0.6	0.9	2.0	-0.4	-1.4	0.0	-0.9	-0.8	-1.2	-1.3	1.0	1.4	0.4	-0.1
Number of self-reported non-cancer illnesses	0.6	1.0	3.6	-0.4	1.4	0.5	0.6	0.1	-0.7	0.8	0.9	1.8	0.3	-1.9
Average weekly champagne plus white wine intake	0.6	0.8	2.9	0.2	0.7	0.4	1.0	-0.2	1.2	0.5	-1.7	-1.2	0.4	0.1
Guilty feelings	0.6	0.9	2.3	0.7	0.6	1.1	-0.6	1.1	-1.3	0.7	1.2	1.5	0.1	-0.0
Medication: Lisinopril	0.6	0.8	1.7	-0.7	-1.2	-0.4	-0.6	-0.7	1.0	-1.3	-1.1	-0.1	0.8	1.0
Arm fat-free mass (left)	0.6	3.0	11.5	-1.1	-1.6	-1.0	-0.6	-0.8	2.6	-1.3	-1.2	-3.4	0.5	2.2
Age started oral contraceptive pill	0.6	0.8	2.6	0.4	0.2	-0.4	-1.6	0.1	-0.0	0.4	0.7	-1.6	-1.0	1.3
Unable to work because of sickness or disability	0.6	0.7	1.9	1.1	0.2	1.4	0.7	0.7	-1.1	0.4	0.6	0.9	-1.1	-0.5
Waist Hip Ratio (WHR)	0.5	2.5	7.9	-2.0	-0.4	-0.7	-0.9	-2.5	0.2	-1.2	-0.9	0.6	2.1	-2.8
Chronotype (morning person)	0.5	1.2	4.6	0.7	0.8	1.3	2.2	1.4	0.3	1.6	-1.0	-0.3	-0.6	-0.3
Sensitivity / hurt feelings	0.5	0.9	4.1	-0.7	-0.6	-1.0	-2.0	-0.5	0.5	-0.6	0.2	-0.5	1.2	1.1
Hearing difficulty/problems: Yes	0.5	0.8	2.2	-0.8	-0.7	-0.2	-1.4	-1.0	0.8	-1.5	-0.5	-0.1	1.3	-0.3
Fed-up feelings	0.5	0.9	2.4	-0.8	-0.8	-1.1	-1.5	-0.2	-0.9	-0.5	1.0	1.5	0.8	-0.7
Hearing difficulty/problems with background noise	0.5	0.8	1.8	-0.9	-0.6	-0.1	-1.4	-1.2	1.0	-1.2	-0.5	-0.8	1.1	0.2
Had menopause	0.5	0.7	2.4	0.1	0.2	-0.1	-1.5	-0.5	0.5	-0.0	0.5	-1.5	-0.3	1.4
Mouth/teeth dental problems	0.5	0.8	2.6	1.4	0.5	0.2	0.4	1.0	-0.1	0.8	0.5	-1.3	-1.6	0.3
Medication: Ramipril	0.5	0.6	1.5	-0.7	-0.8	-1.2	-1.0	-1.0	0.4	-1.2	-0.0	-0.3	0.3	0.2
Neuroticism score	0.5	1.0	4.8	-0.9	-0.5	-1.1	-2.2	-0.4	0.1	-0.5	0.5	0.6	1.6	0.0
Falls in the last year	0.5	0.7	3.5	-1.0	0.0	-0.6	-0.4	-0.4	1.2	-0.4	-1.2	-0.0	1.9	0.0
Breastfed as a baby	0.5	0.6	1.7	-0.3	0.4	-0.3	0.3	-1.1	0.8	-0.4	-1.3	-0.1	0.6	-1.3
Peak expiratory flow (PEF)	0.5	1.2	3.2	0.9	0.9	0.7	1.1	1.7	-0.7	1.8	1.2	-0.3	-1.3	0.3
Wheeze or whistling in the chest in last year	0.5	0.8	1.9	-1.0	0.6	-0.7	-1.0	-1.4	-0.1	0.1	1.1	-0.8	0.8	-1.3
Angina (self-reported)	0.5	0.6	1.7	0.9	0.8	0.9	0.4	1.3	-0.7	0.6	0.6	1.1	-0.4	-0.3
Heart disease (mother)	0.5	0.6	2.2	0.4	0.2	0.6	0.3	1.0	-1.0	0.6	0.9	1.5	0.2	-0.3
Wears glasses or contact lenses	0.5	0.6	1.2	-0.7	-0.6	-1.1	-1.1	-0.6	0.6	-0.9	-0.6	-0.2	0.4	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.9	0.8	0.3	1.3	0.6	0.3	-0.3	1.1	0.8	0.0	-0.7	1.4
Average weekly beer plus cider intake	0.5	0.7	4.1	0.4	-0.3	-1.1	-0.6	0.1	0.0	0.0	0.3	-2.0	-1.2	0.8
Arm predicted mass (left)	0.5	2.6	11.0	-0.8	-1.5	-1.1	-0.4	-0.5	2.4	-1.1	-1.0	-3.3	0.2	2.2
Depressed Affect (Nagel 2018)	0.4	0.8	2.6	-0.8	-0.5	-1.0	-1.6	-0.2	-0.8	-0.2	1.0	1.1	0.9	-0.9
Worry (Nagel 2018)	0.4	0.9	3.3	-1.4	-0.3	-0.7	-1.8	-0.1	0.4	-0.4	-0.3	0.9	1.8	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	0.9	1.1	-0.2	0.5	0.6	0.6	1.1	-0.1	-1.1	-0.4	-0.0
Alzheimer’s Disease (in father)	0.4	0.4	2.1	-0.6	-0.5	-1.1	-1.4	0.1	-0.3	-0.2	0.7	0.3	0.2	0.5
Crohns Disease (2017)	0.4	0.9	2.3	0.7	0.3	0.3	0.9	1.3	-1.4	0.8	1.5	1.2	-0.4	-0.0
Ulcerative Colitis (UC)	0.4	0.8	4.0	0.4	-0.6	0.4	1.6	0.5	-0.3	-0.8	-0.7	-0.2	-0.0	2.0
Triglycerides	0.4	0.6	3.3	-0.4	-0.2	-0.1	-1.5	0.0	-0.7	-0.0	0.4	0.7	-0.1	-1.8
Ulcerative Colitis	0.4	0.6	1.4	0.6	-0.0	1.2	1.1	1.0	-0.9	-0.1	-0.0	0.6	-0.6	0.8
Hand grip strength (left)	0.4	1.1	4.0	0.9	-0.2	0.3	0.1	0.4	0.7	0.2	-0.4	-2.0	-2.0	1.6
Medication for hormone replacement therapy	0.4	0.4	1.2	0.6	-0.1	-0.7	-1.0	0.8	0.2	-0.0	-0.2	-0.6	-0.7	1.1
Hand grip strength (right)	0.4	1.1	4.5	-0.0	-0.6	-0.6	0.0	-0.2	1.3	-0.2	-1.3	-2.1	-0.9	1.5
Serious illness, injury or assault to yourself	0.4	0.5	2.1	-0.2	-0.1	0.9	1.4	-0.1	-0.3	-0.5	-0.2	0.5	0.5	-1.3
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	0.3	0.6	-0.2	-0.0	0.8	-0.9	0.9	0.9	0.9	0.4	-0.4
High blood pressure (mother)	0.4	0.6	1.6	0.0	0.7	1.3	1.1	0.1	0.1	0.8	-0.4	0.7	0.8	-1.1
Impedance of leg (left)	0.4	2.0	6.4	1.1	1.2	0.9	0.8	1.6	-2.5	1.1	1.8	1.9	-0.1	-0.8
Hair/balding pattern: Pattern 2	0.4	0.6	2.8	-0.6	0.6	-1.1	0.5	-0.4	0.4	0.6	0.1	0.1	0.7	-1.7
Pain all over the body in last month	0.4	0.4	1.1	-0.6	-0.6	-1.0	-0.3	-0.5	-0.2	-0.8	-0.3	0.7	0.5	-0.8
Impedance of arm (right)	0.4	2.0	11.0	-1.1	-1.1	-2.0	-3.3	-0.8	0.3	-1.0	0.2	-0.5	1.4	0.8
Time employed in main current job	0.4	0.4	1.6	0.4	-0.7	-0.5	-0.9	0.3	0.1	-0.3	-0.5	0.3	-1.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.9	0.2	-0.3	0.0	1.0	0.8	-0.3	0.4	0.4	-0.4	-0.6	1.7
Birth weight	0.4	0.8	1.8	1.2	0.9	0.4	0.3	1.1	0.1	0.8	-0.3	-1.4	-1.3	0.6
High blood pressure (siblings)	0.4	0.6	1.4	1.0	0.1	-0.5	-0.6	1.1	-1.0	0.4	1.2	1.0	-1.0	-0.1
Arm fat-free mass (right)	0.4	2.2	9.9	-0.7	-1.2	-0.9	-0.1	-0.4	2.3	-0.9	-1.1	-3.1	0.3	1.9
Worry too long after embarrassment	0.4	0.7	4.5	0.4	0.0	-0.2	-0.8	0.8	0.6	0.1	-0.4	-1.1	0.2	2.1
Migraine (self-reported)	0.4	0.6	2.0	0.7	0.0	-0.5	0.2	0.6	-0.8	0.5	0.5	1.4	-1.0	-0.9
Medication: Omeprazole	0.4	0.5	1.3	0.1	0.3	-0.9	0.8	0.8	-0.9	0.6	1.1	0.4	-0.6	0.5
Arm predicted mass (right)	0.4	2.2	9.0	-0.9	-1.2	-1.0	0.1	-0.6	2.4	-0.9	-1.3	-3.0	0.6	1.6
Suffer from ‘nerves’	0.4	0.6	2.3	-0.5	0.6	0.3	0.2	0.7	-0.5	0.7	-0.1	1.5	0.8	-1.3
Supplements: Vitamin C	0.4	0.4	1.4	0.8	0.2	-0.4	-0.7	0.5	-0.8	0.3	1.2	-0.2	-0.5	0.7
Illnesses of father: Heart disease	0.4	0.6	1.4	0.5	-0.6	0.3	-0.7	0.9	-1.0	0.5	1.2	0.9	-0.8	0.2
Illnesses of siblings: Diabetes	0.4	0.6	1.8	0.3	-0.8	0.6	0.2	0.9	-1.3	-0.5	0.8	0.9	-0.8	0.1
Ever had bowel cancer screening	0.4	0.5	1.8	-0.4	-0.5	-0.9	-1.1	-0.1	-0.0	-0.7	0.5	-0.7	-0.0	1.4
Miserableness	0.4	0.7	3.1	-0.2	-0.2	-0.5	-1.0	-0.1	-1.0	0.0	1.1	1.8	0.9	-0.9
Alcohol drinker status: Never	0.4	0.4	2.1	0.9	0.7	-0.4	-0.4	0.6	-0.5	0.2	-0.1	0.6	-1.4	0.2
Leg fat percentage (left)	0.4	1.4	3.6	1.1	1.0	0.2	0.3	1.8	-1.8	1.4	1.9	0.9	-0.0	-0.6
Fractured/broken bones in last 5 years	0.4	0.6	2.3	-0.6	0.6	0.7	1.5	-0.1	0.5	0.9	-0.7	0.7	0.4	-0.6
Diastolic blood pressure, automated reading	0.4	1.2	3.8	-0.9	1.0	0.0	0.3	0.2	1.6	1.4	-1.4	-1.9	0.0	0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	0.4	-0.7	0.6	-1.2	-0.5	-0.2	-0.2	1.2	-0.9	-0.5	0.8
Neuroticism (Nagel 2018)	0.3	0.6	2.6	-0.1	0.2	-0.7	-1.6	0.7	-0.8	0.2	1.0	0.9	0.9	-0.4
Number of treatments/medications taken	0.3	0.5	3.2	-0.6	-0.1	-0.4	-0.5	-0.5	-0.3	-0.1	0.7	1.8	0.8	-0.7
Angina	0.3	0.4	1.5	0.8	0.5	0.7	0.3	1.2	-0.5	0.3	0.6	1.0	-0.4	-0.1
Pack years adult smoking proportion	0.3	0.5	1.7	-0.9	-0.4	0.4	-0.1	-1.1	0.1	-1.3	-0.4	0.7	0.4	-1.0
Impedance of leg (right)	0.3	1.4	4.9	0.9	0.7	0.9	0.6	1.3	-2.2	0.8	1.7	1.6	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.0	0.2	-0.9	0.4	-0.6	0.3	0.4	-0.3	-0.7	-1.2	-0.1	1.7
Multivitamins +/- minerals	0.3	0.3	1.3	-0.7	-0.4	-0.7	-0.2	-0.6	0.1	-0.5	-0.2	0.5	1.2	0.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.1	-0.4	0.4	0.5	0.2	0.2	-1.0	0.2	1.1	0.3	0.5	-0.8
Sitting height	0.3	2.3	6.3	-0.6	-2.2	-2.2	-1.0	0.1	1.4	-1.2	-0.6	-2.0	-0.3	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	3.1	0.0	-1.2	0.9	0.0	0.4	0.1	-0.6	-0.5	-0.9	-0.1	1.8
Weight	0.3	1.3	7.1	-0.4	-0.7	-1.2	-0.8	-0.0	1.5	-0.3	0.1	-2.7	0.5	1.5
Medication: Cholesterol lowering	0.3	0.5	2.7	-0.2	-0.0	0.6	0.3	0.1	-0.7	0.1	1.2	1.6	0.0	-0.2
Hair/balding pattern: Pattern 4	0.3	0.8	2.8	0.5	0.6	1.0	-0.0	0.2	-1.2	0.4	1.5	1.7	0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.0	-0.3	0.7	0.6	0.6	0.4	0.0	0.2	-0.3	1.4	1.1	-0.1
Headache pain in last month	0.3	0.4	1.6	0.7	-0.4	-1.3	0.0	0.5	-0.0	-0.1	-0.2	-0.4	-1.0	1.1
Glaucoma (self-reported)	0.3	0.4	1.4	-0.9	-0.5	-1.2	-0.7	-0.7	-0.2	-0.2	0.1	-0.1	0.7	-0.7
Medication: Amlodipine	0.3	0.4	1.0	-1.0	-0.3	-0.6	0.3	-0.9	0.5	0.2	-0.6	-0.3	0.7	-1.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.0	-0.6	-0.7	-0.8	-0.5	0.3	-0.7	0.5	-0.7	-0.2	0.7
Leg fat percentage (right)	0.3	1.2	3.7	1.0	0.7	0.3	0.3	1.7	-1.7	1.2	1.9	0.7	-0.2	-0.5
Medication: Ibuprofen	0.3	0.4	2.6	0.2	-0.1	-0.0	0.9	0.4	-0.1	0.2	0.4	-0.6	-0.3	1.6
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.0	0.1	-0.3	0.8	0.9	-0.8	0.6	0.6	0.6	-0.5	0.5
Pulse rate, automated reading	0.3	1.0	2.6	-1.1	-0.9	-1.2	-0.4	-1.1	1.1	-1.0	-1.6	-0.1	1.2	0.4
Age at last live birth	0.3	0.4	2.0	0.3	0.3	0.9	0.9	-0.0	-0.0	-0.2	-0.1	-0.3	-0.9	-1.4
Hypertension (Self-reported)	0.3	0.9	1.9	-1.4	-0.0	-1.0	-0.1	-0.5	1.1	-0.3	-1.1	1.0	1.3	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.3	-0.3	0.2	-0.2	0.3	-0.3	0.7	-0.1	-0.6	-1.1	-0.2	1.0
Medication for cholesterol	0.3	0.5	1.8	1.0	0.0	0.4	1.3	0.0	-1.0	0.2	1.2	-0.1	-0.4	-0.1
Heart disease (siblings)	0.3	0.3	1.0	0.1	-0.3	0.8	-0.5	0.8	-1.0	0.1	0.3	1.0	-0.1	-0.3
Pack years of smoking	0.3	0.5	1.4	-0.9	-0.3	0.1	-0.2	-1.2	0.3	-1.2	-0.3	0.6	0.5	-0.8
Irritable Bowel Disease (IBD)	0.2	0.6	1.9	0.6	-0.1	0.6	1.4	1.0	-0.9	0.0	0.4	0.6	-0.1	1.2
Neuroticism (2016)	0.2	0.3	1.8	-0.1	0.3	0.1	-0.6	0.4	-0.8	-0.1	1.3	-0.4	0.4	-0.3
Heel T-Score	0.2	1.9	7.2	1.0	0.8	1.4	0.8	0.8	0.4	0.1	-0.8	-2.3	-1.6	2.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.4	0.3	-0.8	-0.3	-0.0	-0.1	0.1	-0.2	0.2	-0.5	-0.7
Trunk fat percentage	0.2	0.8	3.3	0.3	0.3	-0.8	-1.2	1.0	-0.9	0.8	1.8	-0.4	0.5	0.3
High blood pressure	0.2	0.6	1.7	-1.1	0.1	-0.8	0.2	-0.3	0.8	-0.1	-0.7	1.3	1.0	-1.1
Body mass index (BMI)	0.2	0.8	1.9	0.9	1.0	0.5	0.9	1.1	-0.8	1.3	1.4	0.2	-0.5	-0.5
Trunk fat mass	0.2	0.7	2.1	-0.3	-0.4	-1.1	-1.2	0.5	0.2	0.2	1.0	-1.5	0.8	0.8
Waist circumference	0.2	0.7	2.9	-0.7	-0.4	-1.2	-0.8	-0.6	0.9	-0.4	-0.1	-1.7	0.9	0.5
Hip circumference	0.2	1.0	4.3	0.7	0.2	-0.0	0.3	1.1	0.7	0.5	0.6	-2.1	-0.2	2.0
Impedance of arm (left)	0.2	0.8	4.5	-0.2	0.1	-1.3	-2.1	-0.1	-0.6	0.0	0.9	0.3	0.9	-0.4
Tense / ‘highly strung’	0.2	0.4	1.9	-0.2	0.6	0.4	-0.9	-0.1	-0.5	0.3	1.4	0.4	0.4	-0.7
Birth weight of first child	0.2	0.4	1.6	-0.4	-1.1	-0.5	-0.5	0.3	-0.4	-0.1	1.2	-0.4	-0.3	0.6
Body fat percentage	0.2	0.8	3.2	0.7	0.6	-0.4	-0.5	1.3	-1.1	1.1	1.8	-0.1	0.3	0.0
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.5	0.2	-0.5	-0.1	-0.7	0.7	-0.4	-0.5	-0.5	0.3	-0.2
Knee pain experienced in last month	0.2	0.3	1.3	-0.6	0.2	-0.9	-0.3	-0.1	0.2	0.8	0.6	-0.3	1.2	-0.1
Arm fat percentage (left)	0.2	0.8	2.1	0.7	1.0	-0.4	-0.4	1.0	-0.9	1.3	1.4	0.4	0.4	-0.9
Mood swings	0.2	0.3	0.7	0.0	0.5	0.8	-0.3	0.4	-0.5	0.5	0.9	0.6	0.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.3	0.6	0.0	-0.2	-0.4	-0.2	-0.3	-0.1	0.7	-1.1	-0.8	0.0
Ever taken oral contraceptive pill	0.2	0.3	1.2	-0.2	0.1	-0.6	0.7	0.1	0.8	-0.0	-1.1	0.4	-0.4	0.1
Financial situation satisfaction	0.2	0.2	0.8	-0.4	0.2	-0.5	-0.9	-0.3	0.2	-0.5	-0.2	-0.5	-0.2	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.9	-0.1	0.5	-0.1	0.1	0.1	-0.5	0.7	0.3	-0.5	0.1	-1.0
Medication: Blood pressure	0.2	0.4	1.3	-0.8	0.4	-0.4	-1.0	-0.2	1.2	-0.2	-1.0	-0.4	0.5	-0.2
Medication: Bendroflumethiazide	0.2	0.4	1.2	-0.1	0.7	0.7	0.2	0.5	1.1	0.2	-1.0	0.2	0.3	0.3
Risk taking	0.2	0.2	0.6	0.1	-0.2	0.2	-0.8	-0.3	-0.2	-0.7	0.1	-0.5	-0.8	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.6	0.6	-0.5	0.0	-0.5	-0.2	-0.2	-0.4	0.1	-1.6	-0.5	1.1
Pain experienced in last month	0.2	0.3	1.9	0.7	0.1	1.4	0.2	-0.2	-0.3	0.1	0.3	0.4	-0.6	-0.5
Supplements: Calcium	0.2	0.3	1.1	-0.2	0.4	-0.4	-0.4	-1.0	0.1	-0.4	-0.1	-0.3	0.2	-1.0
Impedance of whole body	0.2	0.8	2.8	0.4	0.7	-0.1	-0.8	0.9	-1.7	0.7	1.6	1.1	0.4	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.2	0.7	-0.7	-0.3	0.1	0.2	0.6	0.3	-0.5	0.0	-0.4
Body Mass Index (BMI) (2010)	0.1	0.2	1.0	0.2	0.0	0.1	0.3	-0.0	-0.6	0.1	0.3	1.0	-0.8	0.2
Lung FEV1/FVC ratio	0.1	0.6	3.1	-1.0	-1.0	-0.5	-1.8	0.0	-0.2	-0.3	-0.3	0.9	0.8	-0.2
Hair Pigment	0.1	1.9	7.2	-0.3	0.6	-0.2	-0.3	-0.6	2.5	-0.6	-2.7	-2.5	0.2	0.0
Tanning	0.1	1.7	4.0	1.7	0.7	1.4	0.8	2.0	-1.5	1.1	1.0	0.2	-1.6	1.5
Vitamin and mineral supplements	0.1	0.2	0.5	0.4	-0.2	0.2	0.0	0.1	0.4	-0.3	-0.7	-0.5	-0.6	0.1
Arm fat percentage (right)	0.1	0.4	1.3	0.3	0.4	-0.7	-0.9	0.7	-0.4	0.8	1.1	-0.1	0.5	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.4	-0.1	0.2	0.1	0.2	-0.7	0.1	0.2	0.7	-0.3	0.8
Arm fat mass (right)	0.1	0.5	1.6	-0.3	-0.4	-1.1	-1.0	0.2	0.6	0.2	0.5	-1.3	0.7	0.6
Exposure to tobacco smoke at home	0.1	0.1	0.5	-0.3	-0.3	0.1	-0.2	0.4	0.1	0.4	0.2	-0.2	-0.3	0.7
Pulse wave reflection index	0.1	0.2	1.3	-0.3	0.4	-0.1	-0.1	0.0	0.0	0.5	0.1	0.3	1.1	0.1
Whole body fat mass	0.1	0.5	2.2	-0.0	-0.2	-1.0	-0.8	0.6	0.2	0.3	0.8	-1.5	0.5	0.9
Leg fat mass (right)	0.1	0.3	1.3	0.3	0.0	-0.4	-0.0	1.0	-0.4	0.5	1.1	-0.7	0.1	0.4
Comparative height size at age 10	0.1	0.5	1.2	-0.6	-0.8	-0.2	-1.1	0.4	0.1	-1.0	0.7	-1.0	0.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.9	0.2	-0.3	-1.0	-0.6	0.2	0.3	0.2	-0.2	0.1	-0.3	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.0	0.0	-0.7	-0.0	-0.7	0.3	-0.3	0.1	0.1	-0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	0.3	0.1	0.2	-0.5	0.3	-0.5	-0.0	0.4	0.6	0.2	0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.5	0.0	0.3	0.7	0.2	-0.5	0.1	-0.4	-0.2	-0.5	-0.1	0.1
Arm fat mass (left)	0.1	0.3	1.2	-0.0	0.0	-0.8	-0.6	0.4	0.4	0.4	0.6	-1.1	0.6	0.2
Mother’s age at death	0.1	0.2	0.8	-0.2	0.4	0.0	-0.1	-0.9	0.4	0.0	0.0	0.2	0.6	-0.5
Irritability	0.1	0.1	0.4	0.6	0.3	-0.3	0.3	0.2	0.4	-0.0	-0.1	-0.6	0.0	0.6
Leg fat mass (left)	0.1	0.3	0.8	0.2	0.0	-0.6	-0.1	0.9	-0.2	0.4	0.8	-0.9	0.3	0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.3	1.2	-0.5	-0.4	-1.1	-0.3	-0.8	0.1	-0.2	0.6	-0.4	0.5	-0.3

Hub : Genes

ACADS

Models

Trait associations