Hub : Genes

ACADS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0510	0.0260	1.6e-02	0.057	0.019	0.047	0.043	0.055	1.5e-07	1.8e-03	1.8e-06	5.0e-06	3.0e-07
2	GTEx	Artery Tibial	0.0889	0.0348	1.5e-03	0.013	NA	0.034	NA	0.041	3.1e-02	NA	1.0e-03	NA	3.6e-04
3	GTEx	Brain Cerebellum	0.4500	0.1060	4.3e-06	0.276	NA	0.276	NA	0.267	8.6e-09	NA	8.8e-09	NA	1.7e-08
4	GTEx	Brain Cortex	0.3980	0.1060	1.9e-04	0.097	NA	0.298	NA	0.209	1.3e-03	NA	6.3e-09	NA	1.9e-06
5	GTEx	Esophagus Muscularis	0.1130	0.0470	3.1e-03	0.041	NA	0.040	NA	0.027	1.6e-03	NA	1.7e-03	NA	8.6e-03
6	GTEx	Muscle Skeletal	0.0865	0.0327	4.3e-04	0.020	NA	0.020	NA	0.023	4.3e-03	NA	4.1e-03	NA	2.4e-03
7	GTEx	Nerve Tibial	0.1389	0.0436	1.1e-05	0.103	NA	0.083	NA	0.083	9.4e-08	NA	1.7e-06	NA	1.8e-06
8	GTEx	Testis	0.1710	0.0570	1.8e-04	0.127	NA	0.074	NA	0.100	2.9e-06	NA	3.4e-04	NA	3.5e-05
9	GTEx	Thyroid	0.2890	0.0510	0.0e+00	0.292	NA	0.302	NA	0.329	1.4e-22	NA	1.9e-23	NA	8.1e-26
10	YFS	Blood	0.0478	0.0148	2.1e-07	0.032	0.030	0.029	0.030	0.029	1.0e-10	3.3e-10	7.6e-10	3.1e-10	9.0e-10
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0509	0.0249	2.3e-03	0.012	0.035	0.034	NA	0.024	1.5e-02	7.4e-05	1.0e-04	NA	9.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.5	2.3	8.3	-1.0	0.3	-0.2	0.9	-1.2	-1.0	-0.5	1.1	2.9	2.1	-2.6
Bipolar Disorder or Schizophrenia	1.9	4.7	14.3	0.5	1.0	1.1	1.5	0.5	-3.4	0.8	3.6	3.8	-0.4	-2.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.6	-0.8	-0.5	-1.0	-1.6	-0.2	-0.8	-0.2	1.0	1.1	0.9	-0.9
Depression (Nagel 2018)	1.4	2.2	5.9	-1.3	-1.1	-1.2	-2.0	-0.5	-1.2	-0.8	0.8	2.4	1.5	-2.1
Intelligence (Savage-Jansen 2018)	1.8	5.6	16.1	-2.1	-1.5	-1.5	-0.0	-4.0	3.0	-2.1	-2.5	-2.3	3.3	-0.2
Neuroticism (Nagel 2018)	0.3	0.6	2.6	-0.1	0.2	-0.7	-1.6	0.7	-0.8	0.2	1.0	0.9	0.9	-0.4
Schizophrenia (2018)	2.2	4.6	13.9	1.4	1.0	1.5	1.2	1.6	-3.5	1.4	3.7	2.5	-2.2	-1.4
Schizophrenia vs Biploar Disorder	1.2	1.6	4.6	1.4	0.7	0.5	-0.8	2.1	-1.4	1.3	1.0	-0.2	-1.8	1.1
Worry (Nagel 2018)	0.4	0.9	3.3	-1.4	-0.3	-0.7	-1.8	-0.1	0.4	-0.4	-0.3	0.9	1.8	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	0.9	1.1	-0.2	0.5	0.6	0.6	1.1	-0.1	-1.1	-0.4	-0.0
Alzheimer’s Disease (in father)	0.4	0.4	2.1	-0.6	-0.5	-1.1	-1.4	0.1	-0.3	-0.2	0.7	0.3	0.2	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.2	0.7	-0.7	-0.3	0.1	0.2	0.6	0.3	-0.5	0.0	-0.4
Crohns Disease (2017)	0.4	0.9	2.3	0.7	0.3	0.3	0.9	1.3	-1.4	0.8	1.5	1.2	-0.4	-0.0
Irritable Bowel Disease (IBD)	0.2	0.6	1.9	0.6	-0.1	0.6	1.4	1.0	-0.9	0.0	0.4	0.6	-0.1	1.2
Ulcerative Colitis (UC)	0.4	0.8	4.0	0.4	-0.6	0.4	1.6	0.5	-0.3	-0.8	-0.7	-0.2	-0.0	2.0
Major Depression (MDD)	1.2	1.5	7.0	-1.0	0.5	0.2	1.0	-1.4	-0.2	-0.0	0.2	1.3	1.9	-2.6
Reaction Time	1.1	2.0	6.8	0.6	0.7	1.5	0.6	0.4	-2.3	0.3	2.3	2.6	-0.2	-1.0
Verbal and Numeric Reasoning (VNR)	1.5	3.6	7.7	-1.9	-1.3	-2.0	-0.4	-2.8	2.3	-1.9	-1.5	-1.8	2.8	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.7	0.9	2.1	0.8	0.6	-0.3	-1.1	1.3	-1.5	0.9	1.1	1.3	-0.5	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.5	3.6	6.6	-1.4	-2.0	-2.2	-1.9	-2.0	2.4	-1.8	-1.7	-2.6	0.8	1.5
Bipolar Disorder (2011)	1.9	1.8	6.8	-1.0	-0.5	-0.6	0.3	-1.2	-1.1	-0.7	0.9	2.0	2.0	-2.6
Body Mass Index (BMI) (2010)	0.1	0.2	1.0	0.2	0.0	0.1	0.3	-0.0	-0.6	0.1	0.3	1.0	-0.8	0.2
Coronary Artery Disease (CAD)	2.1	2.5	5.3	1.3	0.9	2.2	0.8	2.2	-2.3	1.2	1.5	2.0	-1.1	-0.8
Crohns Disease (2012)	1.0	1.6	4.7	1.1	1.1	1.3	0.5	1.5	-1.7	1.2	2.2	0.9	-0.9	-0.6
Mean Putamen Volume	2.2	2.5	7.5	-1.7	-2.7	-2.3	-1.0	-1.0	1.2	-2.2	-1.7	-0.3	1.0	0.3
Fasting Glucose	0.6	0.7	2.2	-1.5	-1.0	0.0	0.2	-1.5	0.3	-0.7	0.1	-0.1	1.2	-0.6
HbA1C	1.7	1.9	13.3	0.2	1.5	0.7	0.3	-0.1	-1.2	0.9	0.5	1.4	-0.2	-3.6
HDL Cholesterol	1.1	1.8	6.0	1.1	1.2	2.0	2.4	1.1	-0.8	1.2	0.6	1.8	-0.2	-0.6
LDL Cholesterol	0.8	1.2	5.5	-0.7	0.1	1.4	0.4	0.5	-0.8	-0.3	0.3	2.3	1.4	-1.6
Lupus	0.8	1.2	3.4	-1.3	-0.8	-0.8	-0.3	-1.1	0.1	-0.6	-0.5	1.8	1.5	-1.5
Neuroticism (2016)	0.2	0.3	1.8	-0.1	0.3	0.1	-0.6	0.4	-0.8	-0.1	1.3	-0.4	0.4	-0.3
Primary Biliary Cirrhosis	1.8	2.6	9.0	0.4	0.8	0.9	2.3	0.9	-2.3	1.1	1.6	3.0	-0.0	-1.4
Rheumatoid Arthritis	1.5	2.0	11.6	0.5	-1.6	-0.9	-1.9	0.2	0.5	-0.8	0.1	-1.7	-0.4	3.4
Schizophrenia (2014)	2.0	4.4	9.8	1.3	1.7	1.7	1.4	2.2	-3.1	2.0	3.0	2.7	-1.5	-1.6
Triglycerides	0.4	0.6	3.3	-0.4	-0.2	-0.1	-1.5	0.0	-0.7	-0.0	0.4	0.7	-0.1	-1.8
Type 2 Diabetes (T2D) (2012)	1.9	2.2	9.3	-0.2	0.2	0.2	-0.4	0.8	-2.0	0.2	0.8	3.1	0.4	-3.0
Ulcerative Colitis	0.4	0.6	1.4	0.6	-0.0	1.2	1.1	1.0	-0.9	-0.1	-0.0	0.6	-0.6	0.8
Blood Eosinophil Count	3.0	22.9	68.7	-2.8	-4.2	-3.7	-4.2	-4.0	5.7	-4.6	-3.8	-8.3	1.8	6.2
Blood Platelet Count	1.1	12.6	53.4	-1.6	-2.9	-0.6	-0.9	-3.1	4.0	-3.0	-2.6	-7.3	-1.4	5.5
Blood Red Count	18.3	176.3	292.8	17.1	16.0	15.9	12.3	16.3	-10.4	16.5	10.4	3.1	-15.0	1.6
Blood White Count	1.7	12.3	30.8	-2.3	-3.5	-3.3	-2.9	-2.3	4.3	-3.5	-3.0	-4.5	1.5	5.5
Heel T-Score	0.2	1.9	7.2	1.0	0.8	1.4	0.8	0.8	0.4	0.1	-0.8	-2.3	-1.6	2.7
BMI	0.0	0.3	1.2	-0.5	-0.4	-1.1	-0.3	-0.8	0.1	-0.2	0.6	-0.4	0.5	-0.3
Height	1.2	23.1	95.8	-3.0	-4.0	-3.5	-5.1	-1.6	5.0	-3.4	-1.8	-9.8	1.2	7.1
Waist Hip Ratio (WHR)	0.5	2.5	7.9	-2.0	-0.4	-0.7	-0.9	-2.5	0.2	-1.2	-0.9	0.6	2.1	-2.8
Systolic Blood Pressure	1.3	6.3	17.5	-2.9	-1.4	-1.1	-1.0	-2.4	4.2	-1.7	-3.8	-2.6	3.0	0.9
Smoking Status	2.4	5.7	18.7	2.0	1.0	1.0	1.2	1.3	-4.2	0.9	4.3	3.1	-2.0	-1.8
Allergy or Eczema	5.1	13.5	50.7	-2.4	-0.8	-2.9	-2.3	-3.4	5.8	-1.4	-4.3	-7.1	3.0	1.8
Cardiovascular Disease	0.6	1.8	7.5	-1.2	0.7	0.2	1.4	-0.2	0.1	0.3	-0.5	2.7	1.9	-2.2
Hypothyroidism (self reported)	2.3	5.2	9.1	-2.3	-1.6	-2.2	-3.0	-2.8	2.3	-1.9	-1.3	-3.0	2.9	0.3
Respiratory disease	2.9	6.5	19.1	-1.6	-1.5	-3.1	-1.6	-2.7	3.3	-2.4	-2.3	-4.4	1.5	2.2
Type 2 Diabetes (T2D) (2018)	1.8	3.4	9.3	-2.2	-1.5	-1.0	-0.4	-1.9	-0.2	-2.5	-1.2	2.2	1.9	-3.0
Lung FEV1/FVC ratio	0.1	0.6	3.1	-1.0	-1.0	-0.5	-1.8	0.0	-0.2	-0.3	-0.3	0.9	0.8	-0.2
Lung FVC	6.8	34.6	60.2	7.8	5.2	6.3	5.5	6.2	-6.5	6.1	6.2	3.1	-7.6	0.4
Neuroticism	0.6	1.4	5.6	-1.3	-0.3	-1.4	-2.4	-0.4	-0.3	-0.2	0.9	1.4	1.6	-0.3
Chronotype (morning person)	0.5	1.2	4.6	0.7	0.8	1.3	2.2	1.4	0.3	1.6	-1.0	-0.3	-0.6	-0.3
Hair Pigment	0.1	1.9	7.2	-0.3	0.6	-0.2	-0.3	-0.6	2.5	-0.6	-2.7	-2.5	0.2	0.0
Tanning	0.1	1.7	4.0	1.7	0.7	1.4	0.8	2.0	-1.5	1.1	1.0	0.2	-1.6	1.5
Hand grip strength (left)	0.4	1.1	4.0	0.9	-0.2	0.3	0.1	0.4	0.7	0.2	-0.4	-2.0	-2.0	1.6
Number of treatments/medications taken	0.3	0.5	3.2	-0.6	-0.1	-0.4	-0.5	-0.5	-0.3	-0.1	0.7	1.8	0.8	-0.7
Average weekly spirits intake	0.6	0.8	2.0	-0.6	-1.0	-1.1	0.5	-1.0	1.4	-1.0	-0.9	-0.5	0.6	0.7
Sensitivity / hurt feelings	0.5	0.9	4.1	-0.7	-0.6	-1.0	-2.0	-0.5	0.5	-0.6	0.2	-0.5	1.2	1.1
Frequency of depressed mood in last 2 weeks	1.3	1.8	9.0	-0.3	0.1	-0.6	-0.6	0.5	-1.4	0.0	0.8	3.0	0.9	-2.6
Hearing difficulty/problems: Yes	0.5	0.8	2.2	-0.8	-0.7	-0.2	-1.4	-1.0	0.8	-1.5	-0.5	-0.1	1.3	-0.3
Relative age of first facial hair	2.8	5.7	17.8	-2.4	-0.2	-1.4	-2.0	-2.8	3.5	-0.7	-2.7	-4.2	2.1	0.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.9	0.4	1.8	1.3	2.0	0.2	-0.7	0.8	0.9	1.0	-0.5	-1.8
Ever used hormone-replacement therapy (HRT)	1.7	2.1	5.5	1.6	2.3	0.8	0.4	2.0	-0.5	2.2	1.2	-0.3	-1.5	1.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.4	0.3	-0.8	-0.3	-0.0	-0.1	0.1	-0.2	0.2	-0.5	-0.7
Systolic blood pressure, automated reading	0.9	2.7	9.1	-1.4	-0.0	-0.3	-0.6	-0.5	3.0	-0.1	-2.3	-2.8	1.2	1.8
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.6	-2.1	-1.4	-0.3	-1.2	-1.6	0.7	-1.8	-0.7	0.6	1.8	-1.3
Angina	0.3	0.4	1.5	0.8	0.5	0.7	0.3	1.2	-0.5	0.3	0.6	1.0	-0.4	-0.1
Medication for hormone replacement therapy	0.4	0.4	1.2	0.6	-0.1	-0.7	-1.0	0.8	0.2	-0.0	-0.2	-0.6	-0.7	1.1
Vitamin and mineral supplements	0.1	0.2	0.5	0.4	-0.2	0.2	0.0	0.1	0.4	-0.3	-0.7	-0.5	-0.6	0.1
Supplements: Zinc	3.0	3.3	5.3	1.6	2.2	2.0	1.9	1.1	-2.3	1.6	2.3	1.7	-1.0	-1.7
Medication: Co-codamol	1.5	1.8	6.3	0.2	0.6	0.7	-0.2	1.1	-1.9	0.6	1.4	2.5	-0.0	-2.2
Medication: Metformin	0.8	1.1	4.5	-1.1	-1.4	-1.4	-0.2	-1.4	0.0	-2.1	-0.8	-0.2	0.3	-0.2
Diabetes (father)	4.0	5.0	8.6	-2.9	-2.9	-2.3	-2.4	-2.4	2.2	-2.6	-2.0	-1.8	1.3	1.0
Diabetes (mother)	2.9	3.7	9.5	1.3	2.1	1.8	2.3	1.2	-2.1	0.9	0.9	2.3	-1.8	-3.1
Severe depression (siblings)	3.1	3.5	8.4	-1.8	-2.7	-1.9	-2.9	-1.8	0.2	-2.2	-0.6	1.7	1.9	-1.0
Pack years adult smoking proportion	0.3	0.5	1.7	-0.9	-0.4	0.4	-0.1	-1.1	0.1	-1.3	-0.4	0.7	0.4	-1.0
Impedance of leg (right)	0.3	1.4	4.9	0.9	0.7	0.9	0.6	1.3	-2.2	0.8	1.7	1.6	-0.2	-0.7
Leg fat-free mass (left)	1.0	5.3	17.0	-1.8	-2.2	-2.3	-1.8	-1.6	3.2	-1.8	-1.7	-4.1	1.1	2.1
Trunk fat percentage	0.2	0.8	3.3	0.3	0.3	-0.8	-1.2	1.0	-0.9	0.8	1.8	-0.4	0.5	0.3
Hand grip strength (right)	0.4	1.1	4.5	-0.0	-0.6	-0.6	0.0	-0.2	1.3	-0.2	-1.3	-2.1	-0.9	1.5
Townsend deprivation index at recruitment	0.6	0.9	2.5	1.0	0.8	0.6	1.1	0.8	-1.6	0.6	1.2	1.1	-0.7	-0.1
Current tobacco smoking	0.7	1.1	2.8	-1.0	-1.7	-0.6	-1.1	-1.3	-0.7	-1.6	0.4	1.1	0.8	-0.3
Average weekly fortified wine intake	0.8	0.9	2.3	-0.8	-0.9	-1.3	-0.4	-0.4	1.1	-1.1	-1.0	0.2	1.5	1.0
Maternal smoking around birth	1.1	1.6	5.1	-0.9	-1.6	-1.4	-2.2	0.1	0.4	-0.8	-0.1	-1.2	0.2	2.3
Fed-up feelings	0.5	0.9	2.4	-0.8	-0.8	-1.1	-1.5	-0.2	-0.9	-0.5	1.0	1.5	0.8	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.7	-1.9	-2.0	-1.8	-2.2	-1.1	-0.0	-1.3	0.0	1.5	1.9	-0.7
Relative age voice broke	1.5	2.3	11.3	-1.2	0.1	-1.0	-0.4	-1.5	2.4	-0.2	-1.4	-3.4	0.5	1.3
Taking other prescription medications	0.6	0.9	3.7	-0.6	0.6	-0.9	-0.3	-0.8	-0.6	-0.3	0.9	0.8	1.3	-1.9
Age when periods started (menarche)	1.9	4.5	16.0	-1.8	-1.5	-0.4	-0.4	-2.5	2.8	-1.7	-1.4	-4.0	0.7	2.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	1.0	1.2	0.3	1.0	1.3	-0.2	1.2	0.1	0.1	-1.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.0	0.2	-0.9	0.4	-0.6	0.3	0.4	-0.3	-0.7	-1.2	-0.1	1.7
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.7	1.4	0.8	1.0	1.3	0.7	-1.8	1.3	1.9	1.3	-1.5	-0.9
Qualifications: CSEs or equivalent	1.1	1.5	6.1	-1.1	-1.3	-2.5	-2.2	-0.5	-0.0	-0.3	-0.0	0.6	1.2	-0.5
Serious illness, injury or assault to yourself	0.4	0.5	2.1	-0.2	-0.1	0.9	1.4	-0.1	-0.3	-0.5	-0.2	0.5	0.5	-1.3
High blood pressure	0.2	0.6	1.7	-1.1	0.1	-0.8	0.2	-0.3	0.8	-0.1	-0.7	1.3	1.0	-1.1
Hayfever, allergic rhinitis or eczema	3.2	7.1	22.4	-1.8	-0.2	-2.5	-1.5	-2.1	4.2	-0.4	-3.4	-4.7	2.9	0.5
Multivitamins +/- minerals	0.3	0.3	1.3	-0.7	-0.4	-0.7	-0.2	-0.6	0.1	-0.5	-0.2	0.5	1.2	0.0
Stomach or abdominal pain in last month	0.7	0.9	2.4	0.3	0.5	-0.6	-0.2	0.6	-1.3	0.3	1.5	1.5	-0.3	-1.4
Supplements: Glucosamine	0.8	1.1	4.0	0.9	1.7	1.3	1.0	0.5	-0.3	2.0	0.7	0.5	-0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.1	-0.4	0.4	0.5	0.2	0.2	-1.0	0.2	1.1	0.3	0.5	-0.8
Medication: Atenolol	1.0	1.2	5.8	-0.1	0.1	1.3	0.7	1.1	-1.5	0.2	0.9	2.4	-0.0	-1.2
Medication: Levothyroxine sodium	1.0	1.8	3.6	-1.2	-0.9	-1.1	-1.1	-1.2	1.9	-1.1	-1.8	-1.7	1.6	0.5
Sitting height	0.3	2.3	6.3	-0.6	-2.2	-2.2	-1.0	0.1	1.4	-1.2	-0.6	-2.0	-0.3	2.5
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	0.3	0.6	-0.2	-0.0	0.8	-0.9	0.9	0.9	0.9	0.4	-0.4
High blood pressure (mother)	0.4	0.6	1.6	0.0	0.7	1.3	1.1	0.1	0.1	0.8	-0.4	0.7	0.8	-1.1
Body mass index (BMI)	0.2	0.8	1.9	0.9	1.0	0.5	0.9	1.1	-0.8	1.3	1.4	0.2	-0.5	-0.5
Impedance of leg (left)	0.4	2.0	6.4	1.1	1.2	0.9	0.8	1.6	-2.5	1.1	1.8	1.9	-0.1	-0.8
Leg predicted mass (left)	1.0	5.5	17.3	-1.8	-2.2	-2.3	-1.9	-1.6	3.3	-1.9	-1.8	-4.2	1.1	2.1
Trunk fat mass	0.2	0.7	2.1	-0.3	-0.4	-1.1	-1.2	0.5	0.2	0.2	1.0	-1.5	0.8	0.8
Waist circumference	0.2	0.7	2.9	-0.7	-0.4	-1.2	-0.8	-0.6	0.9	-0.4	-0.1	-1.7	0.9	0.5
Number of incorrect matches in round	2.2	3.6	6.1	2.4	1.8	1.6	0.8	2.2	-1.9	2.3	2.5	1.0	-2.4	-0.3
Past tobacco smoking	2.5	4.5	12.8	-2.4	-2.1	-1.7	-1.2	-1.7	2.8	-1.9	-3.6	-1.0	2.3	1.2
Alcohol usually taken with meals	0.6	1.0	4.4	0.6	0.3	0.8	0.7	0.0	1.4	-0.1	-0.9	-2.1	-0.2	1.2
Nervous feelings	1.7	3.2	6.2	-2.0	-0.8	-1.7	-2.1	-1.6	2.5	-1.2	-2.4	-1.3	2.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.2	-2.2	-1.2	-0.7	-1.7	-1.3	0.3	-1.1	-0.5	1.3	2.3	-1.6
Hearing difficulty/problems with background noise	0.5	0.8	1.8	-0.9	-0.6	-0.1	-1.4	-1.2	1.0	-1.2	-0.5	-0.8	1.1	0.2
Hair/balding pattern: Pattern 2	0.4	0.6	2.8	-0.6	0.6	-1.1	0.5	-0.4	0.4	0.6	0.1	0.1	0.7	-1.7
Had menopause	0.5	0.7	2.4	0.1	0.2	-0.1	-1.5	-0.5	0.5	-0.0	0.5	-1.5	-0.3	1.4
Had other major operations	1.8	2.2	7.1	1.2	0.9	1.0	1.1	1.9	-1.9	1.2	1.2	2.7	-0.5	-1.6
Forced vital capacity (FVC)	1.5	5.9	17.6	3.4	1.3	1.6	1.8	2.5	-2.1	1.6	2.9	-0.9	-4.2	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	3.1	0.0	-1.2	0.9	0.0	0.4	0.1	-0.6	-0.5	-0.9	-0.1	1.8
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	14.7	-0.4	1.1	0.4	0.9	-0.1	-1.6	0.8	1.5	2.7	0.6	-3.8
Qualifications: None of the above	1.1	2.4	5.7	1.7	0.8	0.5	-0.6	1.9	-2.4	1.3	2.2	1.3	-2.1	0.3
Financial difficulties in last 2 years	1.3	1.8	5.9	-1.0	-1.1	-0.8	-1.5	-0.4	-0.9	-0.9	0.3	2.4	1.4	-2.2
Mouth/teeth dental problems	0.5	0.8	2.6	1.4	0.5	0.2	0.4	1.0	-0.1	0.8	0.5	-1.3	-1.6	0.3
Heart attack	1.7	2.2	4.4	1.8	1.3	1.1	-0.2	2.0	-2.0	1.4	2.1	1.0	-1.7	0.0
Allergy	3.8	8.7	20.2	2.2	0.5	3.2	2.5	2.9	-4.4	1.2	3.6	4.5	-3.5	0.0
Pain all over the body in last month	0.4	0.4	1.1	-0.6	-0.6	-1.0	-0.3	-0.5	-0.2	-0.8	-0.3	0.7	0.5	-0.8
Diabetes (self-reported)	1.8	2.8	5.4	-2.2	-1.6	-1.2	-0.2	-2.1	0.9	-2.3	-1.9	0.4	1.4	-2.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.2	0.0	0.8	0.6	-0.2	0.2	1.7	0.4	-1.1	-1.8	0.0	-0.2
Medication: Ramipril	0.5	0.6	1.5	-0.7	-0.8	-1.2	-1.0	-1.0	0.4	-1.2	-0.0	-0.3	0.3	0.2
Medication: Simvastatin	0.7	1.0	4.6	0.5	0.7	1.1	0.9	0.4	-1.0	0.7	0.7	2.1	-0.4	-1.2
Fluid intelligence score	1.6	3.3	6.0	-1.9	-1.4	-1.4	-0.4	-2.4	2.4	-2.0	-2.1	-1.7	2.3	0.3
Illnesses of siblings	1.0	1.3	3.2	-1.3	0.7	-0.2	0.8	-1.3	1.8	0.4	-1.5	-1.6	1.5	-0.1
Neuroticism score	0.5	1.0	4.8	-0.9	-0.5	-1.1	-2.2	-0.4	0.1	-0.5	0.5	0.6	1.6	0.0
Weight	0.3	1.3	7.1	-0.4	-0.7	-1.2	-0.8	-0.0	1.5	-0.3	0.1	-2.7	0.5	1.5
Impedance of arm (right)	0.4	2.0	11.0	-1.1	-1.1	-2.0	-3.3	-0.8	0.3	-1.0	0.2	-0.5	1.4	0.8
Arm fat percentage (right)	0.1	0.4	1.3	0.3	0.4	-0.7	-0.9	0.7	-0.4	0.8	1.1	-0.1	0.5	-0.3
Trunk fat-free mass	1.0	5.6	17.6	-1.9	-2.1	-1.7	-0.9	-1.7	3.8	-1.9	-2.5	-4.2	1.2	2.0
Hip circumference	0.2	1.0	4.3	0.7	0.2	-0.0	0.3	1.1	0.7	0.5	0.6	-2.1	-0.2	2.0
Time employed in main current job	0.4	0.4	1.6	0.4	-0.7	-0.5	-0.9	0.3	0.1	-0.3	-0.5	0.3	-1.2	1.0
Alcohol intake versus 10 years previously	1.7	2.5	9.1	1.4	0.4	1.3	0.3	0.5	-2.6	-0.1	3.0	2.2	-1.7	-0.1
Father’s age at death	0.7	1.0	4.0	0.9	0.6	1.2	0.8	0.5	0.4	0.8	-0.0	-2.0	-0.5	1.4
Worrier / anxious feelings	1.0	1.9	5.0	1.0	1.4	0.4	-0.4	1.9	-1.5	1.9	1.8	2.2	-0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.9	-1.6	-1.6	-1.4	-1.7	-1.0	0.1	-1.7	-0.6	1.4	1.6	-1.1
Falls in the last year	0.5	0.7	3.5	-1.0	0.0	-0.6	-0.4	-0.4	1.2	-0.4	-1.2	-0.0	1.9	0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.4	-0.1	0.2	0.1	0.2	-0.7	0.1	0.2	0.7	-0.3	0.8
Number of live births	1.7	2.4	4.4	-1.5	-1.6	-1.5	-1.7	-1.5	1.2	-1.5	-1.1	-1.5	2.1	1.7
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	16.1	3.3	1.2	1.5	1.7	2.8	-2.2	2.0	2.6	-0.5	-4.0	1.8
Pulse rate	2.8	4.8	8.8	-1.9	-1.8	-2.1	-0.9	-1.9	2.8	-2.2	-3.0	-2.9	1.4	2.3
Happiness	2.4	2.9	6.5	-1.9	-0.8	-1.2	-1.4	-2.3	2.1	-2.0	-2.6	-0.2	1.9	-0.1
Noisy workplace	3.6	4.5	10.4	2.1	2.3	1.7	0.7	1.7	-2.8	2.1	3.2	1.3	-2.0	-2.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.6	-0.2	-0.0	0.0	0.3	-1.5	2.1	-1.4	-2.1	-0.7	0.8	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.4	-0.3	-0.5	-0.8	0.2	-1.3	0.2	-0.9	-0.3	1.6	0.7	-1.0
Mouth/teeth dental problems: Dentures	0.8	1.3	3.5	-1.9	-0.5	-0.7	-0.3	-1.3	0.2	-0.6	-0.5	1.7	1.7	-1.5
Asthma	5.5	10.8	25.4	-2.3	-2.7	-4.4	-2.9	-3.2	3.8	-3.1	-2.5	-5.0	1.8	3.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.9	0.2	-0.3	0.0	1.0	0.8	-0.3	0.4	0.4	-0.4	-0.6	1.7
Medication: Cholesterol lowering	0.3	0.5	2.7	-0.2	-0.0	0.6	0.3	0.1	-0.7	0.1	1.2	1.6	0.0	-0.2
Depression (self-reported)	2.6	3.1	8.1	1.3	1.4	1.1	1.1	0.7	-2.2	1.3	2.7	2.9	-0.8	-2.3
Medication: Lansoprazole	0.7	0.8	2.7	0.1	0.6	0.2	0.2	0.9	-1.2	0.8	1.1	1.7	-0.7	-0.7
Prospective memory result	1.0	1.2	4.0	-0.9	-1.7	-2.0	-1.6	-0.6	0.5	-1.2	-0.6	0.4	0.8	0.3
Lung cancer (father)	1.0	1.2	2.6	0.7	1.3	0.8	0.1	1.5	-1.6	1.2	1.1	1.3	-0.0	-0.9
Illnesses of mother	1.5	1.9	3.9	-1.2	-2.0	-1.9	-1.4	-1.0	0.7	-1.4	-0.5	-1.5	0.4	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	6.9	20.4	3.9	1.7	2.2	2.2	2.8	-2.4	2.1	2.6	-0.3	-4.5	1.7
Pulse wave Arterial Stiffness index	1.5	1.7	6.5	-1.7	-0.1	-0.8	-0.9	-1.6	1.6	-0.6	-1.5	-0.5	2.5	-0.6
Impedance of arm (left)	0.2	0.8	4.5	-0.2	0.1	-1.3	-2.1	-0.1	-0.6	0.0	0.9	0.3	0.9	-0.4
Arm fat mass (right)	0.1	0.5	1.6	-0.3	-0.4	-1.1	-1.0	0.2	0.6	0.2	0.5	-1.3	0.7	0.6
Trunk predicted mass	1.0	5.7	17.5	-2.0	-2.0	-1.8	-0.9	-1.8	3.8	-2.0	-2.5	-4.2	1.3	1.9
Standing height	1.3	12.6	39.7	-2.6	-3.2	-3.3	-3.4	-2.2	4.7	-2.9	-2.4	-6.3	1.8	4.0
Length of working week for main job	0.7	0.8	2.8	-0.7	-0.4	-0.8	0.5	-0.8	1.6	-0.6	-1.7	-0.8	0.4	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.5	-0.3	-0.3	0.1	-0.2	0.4	0.1	0.4	0.2	-0.2	-0.3	0.7
Breastfed as a baby	0.5	0.6	1.7	-0.3	0.4	-0.3	0.3	-1.1	0.8	-0.4	-1.3	-0.1	0.6	-1.3
Tense / ‘highly strung’	0.2	0.4	1.9	-0.2	0.6	0.4	-0.9	-0.1	-0.5	0.3	1.4	0.4	0.4	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	10.8	0.1	0.1	-0.5	-0.5	0.0	-2.9	0.1	3.3	2.8	0.2	-1.2
Hair/balding pattern: Pattern 4	0.3	0.8	2.8	0.5	0.6	1.0	-0.0	0.2	-1.2	0.4	1.5	1.7	0.4	-0.6
Birth weight of first child	0.2	0.4	1.6	-0.4	-1.1	-0.5	-0.5	0.3	-0.4	-0.1	1.2	-0.4	-0.3	0.6
Peak expiratory flow (PEF)	0.5	1.2	3.2	0.9	0.9	0.7	1.1	1.7	-0.7	1.8	1.2	-0.3	-1.3	0.3
Pulse wave reflection index	0.1	0.2	1.3	-0.3	0.4	-0.1	-0.1	0.0	0.0	0.5	0.1	0.3	1.1	0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.4	-1.1	-0.6	-0.9	-0.6	-1.6	0.0	-1.2	-0.2	1.4	1.1	-1.5
Loud music exposure frequency	1.0	1.1	5.4	1.0	1.2	1.2	2.3	0.9	0.3	0.4	-0.5	0.4	-1.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.7	-0.7	-0.7	-0.4	0.3	-1.1	2.1	-0.9	-2.2	-1.1	0.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.0	-0.3	0.7	0.6	0.6	0.4	0.0	0.2	-0.3	1.4	1.1	-0.1
Blood clot in the leg (DVT)	0.9	1.2	6.8	-0.1	-1.0	-0.8	-2.6	-0.3	-0.8	-0.8	1.2	0.9	0.8	-0.3
Medication: Paracetamol	1.5	2.4	5.1	1.3	1.7	-0.2	1.5	1.8	-2.0	1.8	1.3	2.3	-1.2	-1.2
Headache pain in last month	0.3	0.4	1.6	0.7	-0.4	-1.3	0.0	0.5	-0.0	-0.1	-0.2	-0.4	-1.0	1.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.7	3.5	1.9	1.8	1.2	1.2	1.3	-0.6	1.6	0.5	-1.7	-1.4	0.2
Glaucoma (self-reported)	0.3	0.4	1.4	-0.9	-0.5	-1.2	-0.7	-0.7	-0.2	-0.2	0.1	-0.1	0.7	-0.7
Gout (self-reported)	3.3	4.5	7.2	1.9	2.1	2.7	2.7	2.3	-1.9	2.4	1.9	2.3	-1.5	-1.2
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	6.5	-1.6	-0.8	-1.4	-2.2	-2.1	1.9	-1.0	-1.4	-1.8	2.5	-0.5
Medication: Amlodipine	0.3	0.4	1.0	-1.0	-0.3	-0.6	0.3	-0.9	0.5	0.2	-0.6	-0.3	0.7	-1.0
Medication: Ventolin 100micrograms inhaler	4.4	5.7	14.5	-2.2	-1.6	-3.8	-3.0	-2.5	2.6	-1.7	-1.6	-2.8	1.7	1.4
Birth weight	0.4	0.8	1.8	1.2	0.9	0.4	0.3	1.1	0.1	0.8	-0.3	-1.4	-1.3	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.0	-0.6	-0.7	-0.8	-0.5	0.3	-0.7	0.5	-0.7	-0.2	0.7
High blood pressure (siblings)	0.4	0.6	1.4	1.0	0.1	-0.5	-0.6	1.1	-1.0	0.4	1.2	1.0	-1.0	-0.1
Forced vital capacity (FVC), Best measure	2.1	7.7	22.7	4.1	1.7	2.3	2.5	2.6	-2.3	1.8	3.1	-0.9	-4.8	2.2
Body fat percentage	0.2	0.8	3.2	0.7	0.6	-0.4	-0.5	1.3	-1.1	1.1	1.8	-0.1	0.3	0.0
Leg fat percentage (right)	0.3	1.2	3.7	1.0	0.7	0.3	0.3	1.7	-1.7	1.2	1.9	0.7	-0.2	-0.5
Arm fat-free mass (right)	0.4	2.2	9.9	-0.7	-1.2	-0.9	-0.1	-0.4	2.3	-0.9	-1.1	-3.1	0.3	1.9
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.5	0.2	-0.5	-0.1	-0.7	0.7	-0.4	-0.5	-0.5	0.3	-0.2
Comparative body size at age 10	0.8	2.1	6.2	1.5	0.6	0.5	1.0	1.4	-2.0	0.5	1.1	2.5	-1.5	-1.9
Number of full brothers	2.2	2.7	6.3	2.5	1.0	1.2	1.2	2.1	-2.0	1.6	1.6	0.5	-2.4	-0.4
Worry too long after embarrassment	0.4	0.7	4.5	0.4	0.0	-0.2	-0.8	0.8	0.6	0.1	-0.4	-1.1	0.2	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.1	-1.7	-0.8	-1.2	-1.5	-1.7	-0.9	-1.4	1.0	2.0	1.5	-2.0
Wheeze or whistling in the chest in last year	0.5	0.8	1.9	-1.0	0.6	-0.7	-1.0	-1.4	-0.1	0.1	1.1	-0.8	0.8	-1.3
Number of children fathered	2.5	2.8	6.6	2.1	0.4	1.6	0.1	2.0	-0.8	1.7	1.3	-2.0	-2.6	2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	6.6	-1.7	-2.2	-2.6	-1.5	-1.4	-0.1	-1.7	0.5	-0.3	0.8	-0.6
Age at first live birth	0.9	1.6	3.5	-1.2	-0.8	-0.2	-0.3	-1.4	1.9	-1.6	-1.7	-1.9	0.7	-0.3
Pulse wave peak to peak time	1.2	1.5	6.1	1.6	-0.0	0.7	0.7	1.5	-1.3	0.4	1.3	0.0	-2.5	0.8
Health satisfaction	1.9	2.5	6.2	-1.6	-2.0	-1.0	-1.4	-1.5	1.6	-2.5	-1.5	-1.6	1.2	0.9
Shortness of breath walking on level ground	0.8	1.0	1.6	-0.8	-1.0	-1.0	-0.7	-1.0	1.2	-1.1	-0.5	-1.3	0.8	1.3
Qualifications: College or University degree	0.9	2.8	6.4	-1.8	-0.7	-0.6	1.2	-2.5	2.4	-1.5	-2.3	-1.0	2.1	-0.5
Eye problems/disorders: None of the above	1.6	1.8	3.0	1.7	1.4	0.8	1.3	1.0	-1.5	1.4	1.2	1.4	-1.5	-1.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.0	-1.1	-1.1	-0.1	-0.8	-1.3	1.0	-1.4	-1.0	-0.9	0.6	0.4
Emphysema/chronic bronchitis	4.1	4.6	7.9	1.8	2.7	2.3	1.4	2.2	-2.8	2.4	2.3	1.9	-1.1	-2.0
Medication for pain relief, constipation, heartburn	2.5	4.2	6.7	-2.1	-2.2	-0.6	-2.1	-2.4	2.6	-2.4	-2.4	-1.5	2.4	0.6
Neck or shoulder pain in last month	1.0	1.4	5.7	-0.4	0.8	-0.3	0.3	0.6	-1.7	0.4	1.5	2.4	0.1	-1.9
Medication: Blood pressure	0.9	1.5	3.1	-1.8	-1.5	-0.7	-0.7	-1.2	0.6	-1.5	-0.7	1.6	1.5	-0.8
Angina (self-reported)	0.5	0.6	1.7	0.9	0.8	0.9	0.4	1.3	-0.7	0.6	0.6	1.1	-0.4	-0.3
Migraine (self-reported)	0.4	0.6	2.0	0.7	0.0	-0.5	0.2	0.6	-0.8	0.5	0.5	1.4	-1.0	-0.9
Medication: Ibuprofen	0.3	0.4	2.6	0.2	-0.1	-0.0	0.9	0.4	-0.1	0.2	0.4	-0.6	-0.3	1.6
Medication: Allopurinol	1.2	1.6	4.1	1.1	1.2	1.9	2.0	1.6	-0.7	1.4	0.8	0.8	-0.7	-0.2
Medication: Omeprazole	0.4	0.5	1.3	0.1	0.3	-0.9	0.8	0.8	-0.9	0.6	1.1	0.4	-0.6	0.5
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.0	0.1	-0.3	0.8	0.9	-0.8	0.6	0.6	0.6	-0.5	0.5
Mean time to correctly identify matches	2.2	4.1	9.7	1.3	1.9	2.2	0.7	1.1	-2.9	1.6	3.1	3.1	-0.6	-1.7
Heart disease (mother)	0.5	0.6	2.2	0.4	0.2	0.6	0.3	1.0	-1.0	0.6	0.9	1.5	0.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.5	0.8	1.0	-0.2	0.3	1.4	-1.6	1.9	1.2	1.1	-0.4	-0.8
Whole body fat mass	0.1	0.5	2.2	-0.0	-0.2	-1.0	-0.8	0.6	0.2	0.3	0.8	-1.5	0.5	0.9
Leg fat mass (right)	0.1	0.3	1.3	0.3	0.0	-0.4	-0.0	1.0	-0.4	0.5	1.1	-0.7	0.1	0.4
Arm predicted mass (right)	0.4	2.2	9.0	-0.9	-1.2	-1.0	0.1	-0.6	2.4	-0.9	-1.3	-3.0	0.6	1.6
Pulse rate, automated reading	0.3	1.0	2.6	-1.1	-0.9	-1.2	-0.4	-1.1	1.1	-1.0	-1.6	-0.1	1.2	0.4
Alcohol intake frequency.	0.6	1.3	6.5	0.8	0.3	0.2	-1.2	0.6	-1.4	-0.3	1.3	2.6	-1.2	-0.6
Comparative height size at age 10	0.1	0.5	1.2	-0.6	-0.8	-0.2	-1.1	0.4	0.1	-1.0	0.7	-1.0	0.5	0.7
Number of full sisters	0.6	0.7	2.2	1.3	0.7	1.1	0.4	0.2	-0.6	0.1	1.1	-0.5	-1.5	0.4
Suffer from ‘nerves’	0.4	0.6	2.3	-0.5	0.6	0.3	0.2	0.7	-0.5	0.7	-0.1	1.5	0.8	-1.3
Overall health rating	0.8	1.7	3.9	-2.0	-1.4	-1.3	-2.0	-1.0	-0.2	-1.4	0.2	0.6	1.9	-1.0
Chest pain or discomfort	1.3	1.8	4.6	0.8	1.0	1.2	-0.1	0.7	-1.9	0.8	2.1	1.8	-1.2	-1.6
Had major operations	0.9	1.1	3.7	0.5	0.0	0.0	0.1	0.7	-1.2	-0.1	0.8	1.9	-1.4	-1.7
Age at last live birth	0.3	0.4	2.0	0.3	0.3	0.9	0.9	-0.0	-0.0	-0.2	-0.1	-0.3	-0.9	-1.4
Family relationship satisfaction	2.2	2.7	6.4	-2.0	-0.8	-1.0	-1.4	-1.9	1.9	-1.7	-2.4	0.0	2.5	-0.6
Leg pain on walking	1.3	1.6	2.9	-1.5	-1.7	-1.1	-1.3	-1.2	1.1	-1.6	-0.6	-0.7	1.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	0.6	-0.3	-0.1	-0.7	0.8	-0.2	-0.3	1.0	-1.4	-1.4	1.2
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.4	1.3	1.4	2.0	0.7	1.4	-1.0	1.9	2.1	-0.5	-1.2	0.7
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	5.6	0.9	0.9	0.6	0.2	1.0	0.2	1.4	0.6	-2.4	-1.7	1.5
Medication: Aspirin	1.1	1.5	2.6	1.1	1.6	1.0	0.7	1.2	-1.4	1.2	1.2	1.5	-0.4	-1.6
Supplements: Vitamin C	0.4	0.4	1.4	0.8	0.2	-0.4	-0.7	0.5	-0.8	0.3	1.2	-0.2	-0.5	0.7
Knee pain experienced in last month	0.2	0.3	1.3	-0.6	0.2	-0.9	-0.3	-0.1	0.2	0.8	0.6	-0.3	1.2	-0.1
Hypertension (Self-reported)	0.3	0.9	1.9	-1.4	-0.0	-1.0	-0.1	-0.5	1.1	-0.3	-1.1	1.0	1.3	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.3	-0.3	0.2	-0.2	0.3	-0.3	0.7	-0.1	-0.6	-1.1	-0.2	1.0
Illnesses of father: Heart disease	0.4	0.6	1.4	0.5	-0.6	0.3	-0.7	0.9	-1.0	0.5	1.2	0.9	-0.8	0.2
Illnesses of siblings: Diabetes	0.4	0.6	1.8	0.3	-0.8	0.6	0.2	0.9	-1.3	-0.5	0.8	0.9	-0.8	0.1
Smoking status: Previous	3.0	4.5	9.4	2.4	2.4	1.4	1.6	2.0	-2.4	2.4	3.1	0.6	-2.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	12.8	-1.6	-2.4	-2.5	-1.8	-2.4	3.2	-1.9	-2.0	-3.6	0.6	1.6
Whole body fat-free mass	1.0	5.6	18.0	-1.8	-2.2	-2.0	-1.3	-1.7	3.5	-1.9	-2.1	-4.2	1.1	2.2
Leg fat-free mass (right)	0.9	5.1	16.2	-1.7	-2.0	-2.4	-1.8	-1.5	3.2	-1.7	-1.7	-4.0	1.1	2.1
Arm fat percentage (left)	0.2	0.8	2.1	0.7	1.0	-0.4	-0.4	1.0	-0.9	1.3	1.4	0.4	0.4	-0.9
Average weekly red wine intake	0.7	1.0	3.6	-1.4	-0.6	0.1	-0.4	-1.2	0.6	-1.0	-0.4	-0.7	1.9	-1.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.3	-0.4	-1.5	-0.9	-1.1	-0.2	0.2	-1.4	-0.2	-0.1	0.3	1.3
Mood swings	0.2	0.3	0.7	0.0	0.5	0.8	-0.3	0.4	-0.5	0.5	0.9	0.6	0.6	-0.4
Loneliness, isolation	1.5	2.1	5.8	-1.4	-0.7	-1.0	-2.4	-1.0	-1.2	-0.6	1.6	1.3	1.3	-2.1
Long-standing illness, disability or infirmity	0.7	1.1	2.7	1.0	1.4	1.4	1.6	1.1	-0.4	1.0	0.7	0.2	-1.1	-0.7
Ever had bowel cancer screening	0.4	0.5	1.8	-0.4	-0.5	-0.9	-1.1	-0.1	-0.0	-0.7	0.5	-0.7	-0.0	1.4
Diabetes diagnosed by doctor	1.6	2.7	6.1	-2.1	-1.6	-1.1	-0.3	-1.9	0.6	-2.5	-1.7	1.0	1.2	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.9	0.2	-0.3	-1.0	-0.6	0.2	0.3	0.2	-0.2	0.1	-0.3	-0.1
Friendships satisfaction	1.0	1.2	3.8	-1.6	-0.8	-0.6	-0.1	-1.6	0.8	-1.1	-1.1	0.5	1.9	-0.2
Qualifications: nursing, teaching	1.2	1.9	3.8	1.2	0.9	1.6	1.9	1.1	-1.4	1.2	2.0	1.1	-1.5	-0.6
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.0	0.0	-0.7	-0.0	-0.7	0.3	-0.3	0.1	0.1	-0.4	0.1
Eye problems/disorders: Cataract	0.7	0.8	2.5	-0.5	-1.6	-0.6	-0.7	-0.3	0.7	-1.5	-0.3	-0.7	-0.1	1.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	0.3	0.1	0.2	-0.5	0.3	-0.5	-0.0	0.4	0.6	0.2	0.1
Medication for cholesterol	0.3	0.5	1.8	1.0	0.0	0.4	1.3	0.0	-1.0	0.2	1.2	-0.1	-0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.3	0.6	0.0	-0.2	-0.4	-0.2	-0.3	-0.1	0.7	-1.1	-0.8	0.0
Back pain experienced in last month	1.9	2.8	7.6	1.4	1.0	1.2	1.5	1.3	-2.8	0.8	2.7	1.7	-2.0	-0.4
Mineral and other dietary supplements	0.9	1.2	2.5	-0.8	-1.0	-1.6	-1.0	-0.3	0.9	-1.5	-1.4	-1.5	0.5	-0.1
Breast cancer (self-reported)	0.8	0.9	2.4	-1.6	-0.6	-1.0	-0.3	-1.1	0.9	-1.2	-1.0	-0.7	1.0	-0.3
Asthma (self-reported)	4.8	9.5	23.4	-2.1	-2.3	-4.1	-2.6	-3.1	3.6	-2.8	-2.4	-4.8	1.7	2.9
Osteoporosis (self-reported)	2.3	2.9	6.2	1.7	1.3	0.7	0.6	2.2	-2.3	1.0	2.2	2.5	-2.2	-0.5
Osteoarthritis (self-reported)	2.1	2.7	5.3	1.8	1.8	1.5	0.5	1.6	-2.0	2.0	2.3	1.7	-1.5	-0.7
Medication: Aspirin	0.9	1.1	2.2	1.0	1.4	0.9	0.4	1.2	-1.1	1.2	1.0	1.1	-0.3	-1.5
Medication: Gliclazide	0.9	1.0	2.9	-1.3	-0.5	-1.1	0.0	-1.7	0.5	-0.9	-1.2	-0.5	0.4	-1.5
Illnesses of father: None of the above (group 1)	0.1	0.1	0.5	0.0	0.3	0.7	0.2	-0.5	0.1	-0.4	-0.2	-0.5	-0.1	0.1
Smoking status: Current	0.6	0.9	2.0	-0.4	-1.4	0.0	-0.9	-0.8	-1.2	-1.3	1.0	1.4	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.1	8.6	20.0	3.3	1.6	2.5	2.1	3.2	-4.5	2.4	3.9	2.7	-3.4	-0.9
Whole body water mass	1.0	5.5	17.4	-1.8	-2.2	-2.0	-1.3	-1.7	3.6	-1.9	-2.1	-4.2	1.1	2.2
Leg predicted mass (right)	1.0	5.3	16.6	-1.7	-2.0	-2.4	-1.9	-1.5	3.2	-1.7	-1.8	-4.1	1.1	2.1
Arm fat mass (left)	0.1	0.3	1.2	-0.0	0.0	-0.8	-0.6	0.4	0.4	0.4	0.6	-1.1	0.6	0.2
Number of self-reported non-cancer illnesses	0.6	1.0	3.6	-0.4	1.4	0.5	0.6	0.1	-0.7	0.8	0.9	1.8	0.3	-1.9
Average weekly champagne plus white wine intake	0.6	0.8	2.9	0.2	0.7	0.4	1.0	-0.2	1.2	0.5	-1.7	-1.2	0.4	0.1
Miserableness	0.4	0.7	3.1	-0.2	-0.2	-0.5	-1.0	-0.1	-1.0	0.0	1.1	1.8	0.9	-0.9
Guilty feelings	0.6	0.9	2.3	0.7	0.6	1.1	-0.6	1.1	-1.3	0.7	1.2	1.5	0.1	-0.0
Wears glasses or contact lenses	0.5	0.6	1.2	-0.7	-0.6	-1.1	-1.1	-0.6	0.6	-0.9	-0.6	-0.2	0.4	1.0
Ever taken oral contraceptive pill	0.2	0.3	1.2	-0.2	0.1	-0.6	0.7	0.1	0.8	-0.0	-1.1	0.4	-0.4	0.1
Hearing aid user	0.9	1.1	3.9	0.9	0.7	0.2	0.7	0.6	-1.3	0.2	1.8	0.8	-2.0	0.1
Mother’s age at death	0.1	0.2	0.8	-0.2	0.4	0.0	-0.1	-0.9	0.4	0.0	0.0	0.2	0.6	-0.5
Financial situation satisfaction	0.2	0.2	0.8	-0.4	0.2	-0.5	-0.9	-0.3	0.2	-0.5	-0.2	-0.5	-0.2	-0.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	6.5	0.2	-1.2	-0.3	-1.8	0.3	0.7	-1.0	-0.7	-1.5	-0.4	2.5
Commuting to job workplace: Public transport	2.9	3.5	6.1	-2.1	-1.7	-2.2	-1.4	-2.2	1.9	-2.2	-2.5	0.3	2.0	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.9	-0.1	0.5	-0.1	0.1	0.1	-0.5	0.7	0.3	-0.5	0.1	-1.0
Medication: Blood pressure	0.2	0.4	1.3	-0.8	0.4	-0.4	-1.0	-0.2	1.2	-0.2	-1.0	-0.4	0.5	-0.2
Pain type(s) experienced in last month: Hip pain	1.3	1.6	5.3	-1.1	0.3	-1.0	-0.6	0.3	-1.5	0.4	1.4	2.3	0.6	-2.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.9	0.8	0.3	1.3	0.6	0.3	-0.3	1.1	0.8	0.0	-0.7	1.4
High cholesterol (Self-reported)	1.4	2.4	14.2	0.3	0.3	0.8	1.2	1.1	-2.1	0.7	1.7	3.8	-0.1	-1.2
Medication: Bendroflumethiazide	0.2	0.4	1.2	-0.1	0.7	0.7	0.2	0.5	1.1	0.2	-1.0	0.2	0.3	0.3
Medication: Paracetamol	1.6	2.4	4.3	1.5	1.7	-0.2	1.7	2.1	-1.7	2.0	1.4	1.8	-1.4	-0.4
Medication: Lisinopril	0.6	0.8	1.7	-0.7	-1.2	-0.4	-0.6	-0.7	1.0	-1.3	-1.1	-0.1	0.8	1.0
Medication: Atorvastatin	1.0	1.2	2.8	-1.6	-1.2	-1.0	-1.3	-1.0	-0.3	-0.8	0.4	1.2	1.7	-0.7
Illnesses of father: High blood pressure	0.7	0.8	3.1	1.2	0.8	0.7	0.4	0.9	0.1	1.1	-0.4	0.3	-0.9	-1.8
Alcohol drinker status: Never	0.4	0.4	2.1	0.9	0.7	-0.4	-0.4	0.6	-0.5	0.2	-0.1	0.6	-1.4	0.2
Ever smoked	1.6	2.9	7.8	1.8	1.8	1.5	1.3	1.3	-2.4	1.8	2.8	0.7	-1.6	-0.7
Basal metabolic rate	0.8	4.6	15.8	-1.7	-2.0	-1.9	-1.3	-1.4	3.2	-1.7	-1.7	-4.0	1.1	2.0
Leg fat percentage (left)	0.4	1.4	3.6	1.1	1.0	0.2	0.3	1.8	-1.8	1.4	1.9	0.9	-0.0	-0.6
Arm fat-free mass (left)	0.6	3.0	11.5	-1.1	-1.6	-1.0	-0.6	-0.8	2.6	-1.3	-1.2	-3.4	0.5	2.2
Number of operations (self-reported)	4.0	6.0	15.3	1.6	2.3	1.9	1.2	1.9	-2.6	2.1	2.4	3.9	-1.9	-3.7
Average weekly beer plus cider intake	0.5	0.7	4.1	0.4	-0.3	-1.1	-0.6	0.1	0.0	0.0	0.3	-2.0	-1.2	0.8
Irritability	0.1	0.1	0.4	0.6	0.3	-0.3	0.3	0.2	0.4	-0.0	-0.1	-0.6	0.0	0.6
Risk taking	0.2	0.2	0.6	0.1	-0.2	0.2	-0.8	-0.3	-0.2	-0.7	0.1	-0.5	-0.8	-0.5
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.0	-0.8	-0.1	-0.6	-0.4	-0.7	0.6	-0.6	-1.4	1.2	2.0	-1.9
Fractured/broken bones in last 5 years	0.4	0.6	2.3	-0.6	0.6	0.7	1.5	-0.1	0.5	0.9	-0.7	0.7	0.4	-0.6
Age started oral contraceptive pill	0.6	0.8	2.6	0.4	0.2	-0.4	-1.6	0.1	-0.0	0.4	0.7	-1.6	-1.0	1.3
Diastolic blood pressure, automated reading	0.4	1.2	3.8	-0.9	1.0	0.0	0.3	0.2	1.6	1.4	-1.4	-1.9	0.0	0.6
Ever depressed for a whole week	1.3	1.6	4.9	-1.2	0.4	-0.3	1.5	-0.8	-0.7	-0.1	0.6	2.1	1.6	-2.2
Unable to work because of sickness or disability	0.6	0.7	1.9	1.1	0.2	1.4	0.7	0.7	-1.1	0.4	0.6	0.9	-1.1	-0.5
Commuting to job workplace: Cycle	0.7	0.8	2.7	-1.2	0.3	-0.7	1.6	-0.8	0.5	-0.4	-0.8	0.1	1.1	-1.1
Myopia	1.9	2.8	4.4	-1.5	-1.5	-1.3	-1.9	-1.9	1.8	-1.9	-2.1	-2.0	1.6	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.6	0.6	-0.5	0.0	-0.5	-0.2	-0.2	-0.4	0.1	-1.6	-0.5	1.1
Cholesterol lowering medication	0.8	1.2	4.6	0.2	1.0	0.8	1.3	1.0	-0.9	1.1	0.3	2.1	0.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.7	0.4	1.4	-0.1	1.1	1.3	-1.1	1.6	1.3	0.7	-0.4	-0.8
Pain experienced in last month	0.2	0.3	1.9	0.7	0.1	1.4	0.2	-0.2	-0.3	0.1	0.3	0.4	-0.6	-0.5
Supplements: Calcium	0.2	0.3	1.1	-0.2	0.4	-0.4	-0.4	-1.0	0.1	-0.4	-0.1	-0.3	0.2	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	0.4	-0.7	0.6	-1.2	-0.5	-0.2	-0.2	1.2	-0.9	-0.5	0.8
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.4	1.5	1.1	0.7	-0.5	1.6	-1.4	1.0	1.4	0.6	-1.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	5.6	-0.2	-0.8	-0.5	-2.4	-0.4	-0.9	-0.8	1.2	1.2	0.9	-0.6
Heart disease (siblings)	0.3	0.3	1.0	0.1	-0.3	0.8	-0.5	0.8	-1.0	0.1	0.3	1.0	-0.1	-0.3
Alcohol drinker status: Previous	1.2	1.4	8.0	0.7	0.6	0.9	0.5	0.7	-1.2	0.7	0.5	2.8	0.4	-1.5
Pack years of smoking	0.3	0.5	1.4	-0.9	-0.3	0.1	-0.2	-1.2	0.3	-1.2	-0.3	0.6	0.5	-0.8
Impedance of whole body	0.2	0.8	2.8	0.4	0.7	-0.1	-0.8	0.9	-1.7	0.7	1.6	1.1	0.4	-0.4
Leg fat mass (left)	0.1	0.3	0.8	0.2	0.0	-0.6	-0.1	0.9	-0.2	0.4	0.8	-0.9	0.3	0.5
Arm predicted mass (left)	0.5	2.6	11.0	-0.8	-1.5	-1.1	-0.4	-0.5	2.4	-1.1	-1.0	-3.3	0.2	2.2