Hub : Genes

ACADS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0510 0.0260 1.6e-02 0.057 0.019 0.047 0.043 0.055 1.5e-07 1.8e-03 1.8e-06 5.0e-06 3.0e-07
2 GTEx Artery Tibial 0.0889 0.0348 1.5e-03 0.013 NA 0.034 NA 0.041 3.1e-02 NA 1.0e-03 NA 3.6e-04
3 GTEx Brain Cerebellum 0.4500 0.1060 4.3e-06 0.276 NA 0.276 NA 0.267 8.6e-09 NA 8.8e-09 NA 1.7e-08
4 GTEx Brain Cortex 0.3980 0.1060 1.9e-04 0.097 NA 0.298 NA 0.209 1.3e-03 NA 6.3e-09 NA 1.9e-06
5 GTEx Esophagus Muscularis 0.1130 0.0470 3.1e-03 0.041 NA 0.040 NA 0.027 1.6e-03 NA 1.7e-03 NA 8.6e-03
6 GTEx Muscle Skeletal 0.0865 0.0327 4.3e-04 0.020 NA 0.020 NA 0.023 4.3e-03 NA 4.1e-03 NA 2.4e-03
7 GTEx Nerve Tibial 0.1389 0.0436 1.1e-05 0.103 NA 0.083 NA 0.083 9.4e-08 NA 1.7e-06 NA 1.8e-06
8 GTEx Testis 0.1710 0.0570 1.8e-04 0.127 NA 0.074 NA 0.100 2.9e-06 NA 3.4e-04 NA 3.5e-05
9 GTEx Thyroid 0.2890 0.0510 0.0e+00 0.292 NA 0.302 NA 0.329 1.4e-22 NA 1.9e-23 NA 8.1e-26
10 YFS Blood 0.0478 0.0148 2.1e-07 0.032 0.030 0.029 0.030 0.029 1.0e-10 3.3e-10 7.6e-10 3.1e-10 9.0e-10
11 TCGA Head and Neck Squamous Cell Carcinoma 0.0509 0.0249 2.3e-03 0.012 0.035 0.034 NA 0.024 1.5e-02 7.4e-05 1.0e-04 NA 9.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 1.5 2.3 8.3 -1.0 0.3 -0.2 0.9 -1.2 -1.0 -0.5 1.1 2.9 2.1 -2.6
Bipolar Disorder or Schizophrenia 1.9 4.7 14.3 0.5 1.0 1.1 1.5 0.5 -3.4 0.8 3.6 3.8 -0.4 -2.8
Depressed Affect (Nagel 2018) 0.4 0.8 2.6 -0.8 -0.5 -1.0 -1.6 -0.2 -0.8 -0.2 1.0 1.1 0.9 -0.9
Depression (Nagel 2018) 1.4 2.2 5.9 -1.3 -1.1 -1.2 -2.0 -0.5 -1.2 -0.8 0.8 2.4 1.5 -2.1
Intelligence (Savage-Jansen 2018) 1.8 5.6 16.1 -2.1 -1.5 -1.5 -0.0 -4.0 3.0 -2.1 -2.5 -2.3 3.3 -0.2
Neuroticism (Nagel 2018) 0.3 0.6 2.6 -0.1 0.2 -0.7 -1.6 0.7 -0.8 0.2 1.0 0.9 0.9 -0.4
Schizophrenia (2018) 2.2 4.6 13.9 1.4 1.0 1.5 1.2 1.6 -3.5 1.4 3.7 2.5 -2.2 -1.4
Schizophrenia vs Biploar Disorder 1.2 1.6 4.6 1.4 0.7 0.5 -0.8 2.1 -1.4 1.3 1.0 -0.2 -1.8 1.1
Worry (Nagel 2018) 0.4 0.9 3.3 -1.4 -0.3 -0.7 -1.8 -0.1 0.4 -0.4 -0.3 0.9 1.8 -0.5
Alzheimer’s Disease (in mother) 0.4 0.5 1.2 0.9 1.1 -0.2 0.5 0.6 0.6 1.1 -0.1 -1.1 -0.4 -0.0
Alzheimer’s Disease (in father) 0.4 0.4 2.1 -0.6 -0.5 -1.1 -1.4 0.1 -0.3 -0.2 0.7 0.3 0.2 0.5
Alzheimer’s Disease (including proxy) 0.1 0.2 0.6 0.2 0.7 -0.7 -0.3 0.1 0.2 0.6 0.3 -0.5 0.0 -0.4
Crohns Disease (2017) 0.4 0.9 2.3 0.7 0.3 0.3 0.9 1.3 -1.4 0.8 1.5 1.2 -0.4 -0.0
Irritable Bowel Disease (IBD) 0.2 0.6 1.9 0.6 -0.1 0.6 1.4 1.0 -0.9 0.0 0.4 0.6 -0.1 1.2
Ulcerative Colitis (UC) 0.4 0.8 4.0 0.4 -0.6 0.4 1.6 0.5 -0.3 -0.8 -0.7 -0.2 -0.0 2.0
Major Depression (MDD) 1.2 1.5 7.0 -1.0 0.5 0.2 1.0 -1.4 -0.2 -0.0 0.2 1.3 1.9 -2.6
Reaction Time 1.1 2.0 6.8 0.6 0.7 1.5 0.6 0.4 -2.3 0.3 2.3 2.6 -0.2 -1.0
Verbal and Numeric Reasoning (VNR) 1.5 3.6 7.7 -1.9 -1.3 -2.0 -0.4 -2.8 2.3 -1.9 -1.5 -1.8 2.8 -0.5
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.7 0.9 2.1 0.8 0.6 -0.3 -1.1 1.3 -1.5 0.9 1.1 1.3 -0.5 0.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.5 3.6 6.6 -1.4 -2.0 -2.2 -1.9 -2.0 2.4 -1.8 -1.7 -2.6 0.8 1.5
Bipolar Disorder (2011) 1.9 1.8 6.8 -1.0 -0.5 -0.6 0.3 -1.2 -1.1 -0.7 0.9 2.0 2.0 -2.6
Body Mass Index (BMI) (2010) 0.1 0.2 1.0 0.2 0.0 0.1 0.3 -0.0 -0.6 0.1 0.3 1.0 -0.8 0.2
Coronary Artery Disease (CAD) 2.1 2.5 5.3 1.3 0.9 2.2 0.8 2.2 -2.3 1.2 1.5 2.0 -1.1 -0.8
Crohns Disease (2012) 1.0 1.6 4.7 1.1 1.1 1.3 0.5 1.5 -1.7 1.2 2.2 0.9 -0.9 -0.6
Mean Putamen Volume 2.2 2.5 7.5 -1.7 -2.7 -2.3 -1.0 -1.0 1.2 -2.2 -1.7 -0.3 1.0 0.3
Fasting Glucose 0.6 0.7 2.2 -1.5 -1.0 0.0 0.2 -1.5 0.3 -0.7 0.1 -0.1 1.2 -0.6
HbA1C 1.7 1.9 13.3 0.2 1.5 0.7 0.3 -0.1 -1.2 0.9 0.5 1.4 -0.2 -3.6
HDL Cholesterol 1.1 1.8 6.0 1.1 1.2 2.0 2.4 1.1 -0.8 1.2 0.6 1.8 -0.2 -0.6
LDL Cholesterol 0.8 1.2 5.5 -0.7 0.1 1.4 0.4 0.5 -0.8 -0.3 0.3 2.3 1.4 -1.6
Lupus 0.8 1.2 3.4 -1.3 -0.8 -0.8 -0.3 -1.1 0.1 -0.6 -0.5 1.8 1.5 -1.5
Neuroticism (2016) 0.2 0.3 1.8 -0.1 0.3 0.1 -0.6 0.4 -0.8 -0.1 1.3 -0.4 0.4 -0.3
Primary Biliary Cirrhosis 1.8 2.6 9.0 0.4 0.8 0.9 2.3 0.9 -2.3 1.1 1.6 3.0 -0.0 -1.4
Rheumatoid Arthritis 1.5 2.0 11.6 0.5 -1.6 -0.9 -1.9 0.2 0.5 -0.8 0.1 -1.7 -0.4 3.4
Schizophrenia (2014) 2.0 4.4 9.8 1.3 1.7 1.7 1.4 2.2 -3.1 2.0 3.0 2.7 -1.5 -1.6
Triglycerides 0.4 0.6 3.3 -0.4 -0.2 -0.1 -1.5 0.0 -0.7 -0.0 0.4 0.7 -0.1 -1.8
Type 2 Diabetes (T2D) (2012) 1.9 2.2 9.3 -0.2 0.2 0.2 -0.4 0.8 -2.0 0.2 0.8 3.1 0.4 -3.0
Ulcerative Colitis 0.4 0.6 1.4 0.6 -0.0 1.2 1.1 1.0 -0.9 -0.1 -0.0 0.6 -0.6 0.8
Blood Eosinophil Count 3.0 22.9 68.7 -2.8 -4.2 -3.7 -4.2 -4.0 5.7 -4.6 -3.8 -8.3 1.8 6.2
Blood Platelet Count 1.1 12.6 53.4 -1.6 -2.9 -0.6 -0.9 -3.1 4.0 -3.0 -2.6 -7.3 -1.4 5.5
Blood Red Count 18.3 176.3 292.8 17.1 16.0 15.9 12.3 16.3 -10.4 16.5 10.4 3.1 -15.0 1.6
Blood White Count 1.7 12.3 30.8 -2.3 -3.5 -3.3 -2.9 -2.3 4.3 -3.5 -3.0 -4.5 1.5 5.5
Heel T-Score 0.2 1.9 7.2 1.0 0.8 1.4 0.8 0.8 0.4 0.1 -0.8 -2.3 -1.6 2.7
BMI 0.0 0.3 1.2 -0.5 -0.4 -1.1 -0.3 -0.8 0.1 -0.2 0.6 -0.4 0.5 -0.3
Height 1.2 23.1 95.8 -3.0 -4.0 -3.5 -5.1 -1.6 5.0 -3.4 -1.8 -9.8 1.2 7.1
Waist Hip Ratio (WHR) 0.5 2.5 7.9 -2.0 -0.4 -0.7 -0.9 -2.5 0.2 -1.2 -0.9 0.6 2.1 -2.8
Systolic Blood Pressure 1.3 6.3 17.5 -2.9 -1.4 -1.1 -1.0 -2.4 4.2 -1.7 -3.8 -2.6 3.0 0.9
Smoking Status 2.4 5.7 18.7 2.0 1.0 1.0 1.2 1.3 -4.2 0.9 4.3 3.1 -2.0 -1.8
Allergy or Eczema 5.1 13.5 50.7 -2.4 -0.8 -2.9 -2.3 -3.4 5.8 -1.4 -4.3 -7.1 3.0 1.8
Cardiovascular Disease 0.6 1.8 7.5 -1.2 0.7 0.2 1.4 -0.2 0.1 0.3 -0.5 2.7 1.9 -2.2
Hypothyroidism (self reported) 2.3 5.2 9.1 -2.3 -1.6 -2.2 -3.0 -2.8 2.3 -1.9 -1.3 -3.0 2.9 0.3
Respiratory disease 2.9 6.5 19.1 -1.6 -1.5 -3.1 -1.6 -2.7 3.3 -2.4 -2.3 -4.4 1.5 2.2
Type 2 Diabetes (T2D) (2018) 1.8 3.4 9.3 -2.2 -1.5 -1.0 -0.4 -1.9 -0.2 -2.5 -1.2 2.2 1.9 -3.0
Lung FEV1/FVC ratio 0.1 0.6 3.1 -1.0 -1.0 -0.5 -1.8 0.0 -0.2 -0.3 -0.3 0.9 0.8 -0.2
Lung FVC 6.8 34.6 60.2 7.8 5.2 6.3 5.5 6.2 -6.5 6.1 6.2 3.1 -7.6 0.4
Neuroticism 0.6 1.4 5.6 -1.3 -0.3 -1.4 -2.4 -0.4 -0.3 -0.2 0.9 1.4 1.6 -0.3
Chronotype (morning person) 0.5 1.2 4.6 0.7 0.8 1.3 2.2 1.4 0.3 1.6 -1.0 -0.3 -0.6 -0.3
Hair Pigment 0.1 1.9 7.2 -0.3 0.6 -0.2 -0.3 -0.6 2.5 -0.6 -2.7 -2.5 0.2 0.0
Tanning 0.1 1.7 4.0 1.7 0.7 1.4 0.8 2.0 -1.5 1.1 1.0 0.2 -1.6 1.5
Hand grip strength (left) 0.4 1.1 4.0 0.9 -0.2 0.3 0.1 0.4 0.7 0.2 -0.4 -2.0 -2.0 1.6
Number of treatments/medications taken 0.3 0.5 3.2 -0.6 -0.1 -0.4 -0.5 -0.5 -0.3 -0.1 0.7 1.8 0.8 -0.7
Average weekly spirits intake 0.6 0.8 2.0 -0.6 -1.0 -1.1 0.5 -1.0 1.4 -1.0 -0.9 -0.5 0.6 0.7
Sensitivity / hurt feelings 0.5 0.9 4.1 -0.7 -0.6 -1.0 -2.0 -0.5 0.5 -0.6 0.2 -0.5 1.2 1.1
Frequency of depressed mood in last 2 weeks 1.3 1.8 9.0 -0.3 0.1 -0.6 -0.6 0.5 -1.4 0.0 0.8 3.0 0.9 -2.6
Hearing difficulty/problems: Yes 0.5 0.8 2.2 -0.8 -0.7 -0.2 -1.4 -1.0 0.8 -1.5 -0.5 -0.1 1.3 -0.3
Relative age of first facial hair 2.8 5.7 17.8 -2.4 -0.2 -1.4 -2.0 -2.8 3.5 -0.7 -2.7 -4.2 2.1 0.6
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 3.9 0.4 1.8 1.3 2.0 0.2 -0.7 0.8 0.9 1.0 -0.5 -1.8
Ever used hormone-replacement therapy (HRT) 1.7 2.1 5.5 1.6 2.3 0.8 0.4 2.0 -0.5 2.2 1.2 -0.3 -1.5 1.0
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.4 0.3 -0.8 -0.3 -0.0 -0.1 0.1 -0.2 0.2 -0.5 -0.7
Systolic blood pressure, automated reading 0.9 2.7 9.1 -1.4 -0.0 -0.3 -0.6 -0.5 3.0 -0.1 -2.3 -2.8 1.2 1.8
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 4.6 -2.1 -1.4 -0.3 -1.2 -1.6 0.7 -1.8 -0.7 0.6 1.8 -1.3
Angina 0.3 0.4 1.5 0.8 0.5 0.7 0.3 1.2 -0.5 0.3 0.6 1.0 -0.4 -0.1
Medication for hormone replacement therapy 0.4 0.4 1.2 0.6 -0.1 -0.7 -1.0 0.8 0.2 -0.0 -0.2 -0.6 -0.7 1.1
Vitamin and mineral supplements 0.1 0.2 0.5 0.4 -0.2 0.2 0.0 0.1 0.4 -0.3 -0.7 -0.5 -0.6 0.1
Supplements: Zinc 3.0 3.3 5.3 1.6 2.2 2.0 1.9 1.1 -2.3 1.6 2.3 1.7 -1.0 -1.7
Medication: Co-codamol 1.5 1.8 6.3 0.2 0.6 0.7 -0.2 1.1 -1.9 0.6 1.4 2.5 -0.0 -2.2
Medication: Metformin 0.8 1.1 4.5 -1.1 -1.4 -1.4 -0.2 -1.4 0.0 -2.1 -0.8 -0.2 0.3 -0.2
Diabetes (father) 4.0 5.0 8.6 -2.9 -2.9 -2.3 -2.4 -2.4 2.2 -2.6 -2.0 -1.8 1.3 1.0
Diabetes (mother) 2.9 3.7 9.5 1.3 2.1 1.8 2.3 1.2 -2.1 0.9 0.9 2.3 -1.8 -3.1
Severe depression (siblings) 3.1 3.5 8.4 -1.8 -2.7 -1.9 -2.9 -1.8 0.2 -2.2 -0.6 1.7 1.9 -1.0
Pack years adult smoking proportion 0.3 0.5 1.7 -0.9 -0.4 0.4 -0.1 -1.1 0.1 -1.3 -0.4 0.7 0.4 -1.0
Impedance of leg (right) 0.3 1.4 4.9 0.9 0.7 0.9 0.6 1.3 -2.2 0.8 1.7 1.6 -0.2 -0.7
Leg fat-free mass (left) 1.0 5.3 17.0 -1.8 -2.2 -2.3 -1.8 -1.6 3.2 -1.8 -1.7 -4.1 1.1 2.1
Trunk fat percentage 0.2 0.8 3.3 0.3 0.3 -0.8 -1.2 1.0 -0.9 0.8 1.8 -0.4 0.5 0.3
Hand grip strength (right) 0.4 1.1 4.5 -0.0 -0.6 -0.6 0.0 -0.2 1.3 -0.2 -1.3 -2.1 -0.9 1.5
Townsend deprivation index at recruitment 0.6 0.9 2.5 1.0 0.8 0.6 1.1 0.8 -1.6 0.6 1.2 1.1 -0.7 -0.1
Current tobacco smoking 0.7 1.1 2.8 -1.0 -1.7 -0.6 -1.1 -1.3 -0.7 -1.6 0.4 1.1 0.8 -0.3
Average weekly fortified wine intake 0.8 0.9 2.3 -0.8 -0.9 -1.3 -0.4 -0.4 1.1 -1.1 -1.0 0.2 1.5 1.0
Maternal smoking around birth 1.1 1.6 5.1 -0.9 -1.6 -1.4 -2.2 0.1 0.4 -0.8 -0.1 -1.2 0.2 2.3
Fed-up feelings 0.5 0.9 2.4 -0.8 -0.8 -1.1 -1.5 -0.2 -0.9 -0.5 1.0 1.5 0.8 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 4.7 -1.9 -2.0 -1.8 -2.2 -1.1 -0.0 -1.3 0.0 1.5 1.9 -0.7
Relative age voice broke 1.5 2.3 11.3 -1.2 0.1 -1.0 -0.4 -1.5 2.4 -0.2 -1.4 -3.4 0.5 1.3
Taking other prescription medications 0.6 0.9 3.7 -0.6 0.6 -0.9 -0.3 -0.8 -0.6 -0.3 0.9 0.8 1.3 -1.9
Age when periods started (menarche) 1.9 4.5 16.0 -1.8 -1.5 -0.4 -0.4 -2.5 2.8 -1.7 -1.4 -4.0 0.7 2.9
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.0 1.0 1.2 0.3 1.0 1.3 -0.2 1.2 0.1 0.1 -1.4 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 3.0 0.2 -0.9 0.4 -0.6 0.3 0.4 -0.3 -0.7 -1.2 -0.1 1.7
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.7 1.4 0.8 1.0 1.3 0.7 -1.8 1.3 1.9 1.3 -1.5 -0.9
Qualifications: CSEs or equivalent 1.1 1.5 6.1 -1.1 -1.3 -2.5 -2.2 -0.5 -0.0 -0.3 -0.0 0.6 1.2 -0.5
Serious illness, injury or assault to yourself 0.4 0.5 2.1 -0.2 -0.1 0.9 1.4 -0.1 -0.3 -0.5 -0.2 0.5 0.5 -1.3
High blood pressure 0.2 0.6 1.7 -1.1 0.1 -0.8 0.2 -0.3 0.8 -0.1 -0.7 1.3 1.0 -1.1
Hayfever, allergic rhinitis or eczema 3.2 7.1 22.4 -1.8 -0.2 -2.5 -1.5 -2.1 4.2 -0.4 -3.4 -4.7 2.9 0.5
Multivitamins +/- minerals 0.3 0.3 1.3 -0.7 -0.4 -0.7 -0.2 -0.6 0.1 -0.5 -0.2 0.5 1.2 0.0
Stomach or abdominal pain in last month 0.7 0.9 2.4 0.3 0.5 -0.6 -0.2 0.6 -1.3 0.3 1.5 1.5 -0.3 -1.4
Supplements: Glucosamine 0.8 1.1 4.0 0.9 1.7 1.3 1.0 0.5 -0.3 2.0 0.7 0.5 -0.2 -0.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.1 -0.4 0.4 0.5 0.2 0.2 -1.0 0.2 1.1 0.3 0.5 -0.8
Medication: Atenolol 1.0 1.2 5.8 -0.1 0.1 1.3 0.7 1.1 -1.5 0.2 0.9 2.4 -0.0 -1.2
Medication: Levothyroxine sodium 1.0 1.8 3.6 -1.2 -0.9 -1.1 -1.1 -1.2 1.9 -1.1 -1.8 -1.7 1.6 0.5
Sitting height 0.3 2.3 6.3 -0.6 -2.2 -2.2 -1.0 0.1 1.4 -1.2 -0.6 -2.0 -0.3 2.5
Chronic bronchitis/emphysema (father) 0.4 0.4 0.9 0.3 0.6 -0.2 -0.0 0.8 -0.9 0.9 0.9 0.9 0.4 -0.4
High blood pressure (mother) 0.4 0.6 1.6 0.0 0.7 1.3 1.1 0.1 0.1 0.8 -0.4 0.7 0.8 -1.1
Body mass index (BMI) 0.2 0.8 1.9 0.9 1.0 0.5 0.9 1.1 -0.8 1.3 1.4 0.2 -0.5 -0.5
Impedance of leg (left) 0.4 2.0 6.4 1.1 1.2 0.9 0.8 1.6 -2.5 1.1 1.8 1.9 -0.1 -0.8
Leg predicted mass (left) 1.0 5.5 17.3 -1.8 -2.2 -2.3 -1.9 -1.6 3.3 -1.9 -1.8 -4.2 1.1 2.1
Trunk fat mass 0.2 0.7 2.1 -0.3 -0.4 -1.1 -1.2 0.5 0.2 0.2 1.0 -1.5 0.8 0.8
Waist circumference 0.2 0.7 2.9 -0.7 -0.4 -1.2 -0.8 -0.6 0.9 -0.4 -0.1 -1.7 0.9 0.5
Number of incorrect matches in round 2.2 3.6 6.1 2.4 1.8 1.6 0.8 2.2 -1.9 2.3 2.5 1.0 -2.4 -0.3
Past tobacco smoking 2.5 4.5 12.8 -2.4 -2.1 -1.7 -1.2 -1.7 2.8 -1.9 -3.6 -1.0 2.3 1.2
Alcohol usually taken with meals 0.6 1.0 4.4 0.6 0.3 0.8 0.7 0.0 1.4 -0.1 -0.9 -2.1 -0.2 1.2
Nervous feelings 1.7 3.2 6.2 -2.0 -0.8 -1.7 -2.1 -1.6 2.5 -1.2 -2.4 -1.3 2.4 -0.2
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 5.2 -2.2 -1.2 -0.7 -1.7 -1.3 0.3 -1.1 -0.5 1.3 2.3 -1.6
Hearing difficulty/problems with background noise 0.5 0.8 1.8 -0.9 -0.6 -0.1 -1.4 -1.2 1.0 -1.2 -0.5 -0.8 1.1 0.2
Hair/balding pattern: Pattern 2 0.4 0.6 2.8 -0.6 0.6 -1.1 0.5 -0.4 0.4 0.6 0.1 0.1 0.7 -1.7
Had menopause 0.5 0.7 2.4 0.1 0.2 -0.1 -1.5 -0.5 0.5 -0.0 0.5 -1.5 -0.3 1.4
Had other major operations 1.8 2.2 7.1 1.2 0.9 1.0 1.1 1.9 -1.9 1.2 1.2 2.7 -0.5 -1.6
Forced vital capacity (FVC) 1.5 5.9 17.6 3.4 1.3 1.6 1.8 2.5 -2.1 1.6 2.9 -0.9 -4.2 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 3.1 0.0 -1.2 0.9 0.0 0.4 0.1 -0.6 -0.5 -0.9 -0.1 1.8
Ever unenthusiastic/disinterested for a whole week 2.3 2.8 14.7 -0.4 1.1 0.4 0.9 -0.1 -1.6 0.8 1.5 2.7 0.6 -3.8
Qualifications: None of the above 1.1 2.4 5.7 1.7 0.8 0.5 -0.6 1.9 -2.4 1.3 2.2 1.3 -2.1 0.3
Financial difficulties in last 2 years 1.3 1.8 5.9 -1.0 -1.1 -0.8 -1.5 -0.4 -0.9 -0.9 0.3 2.4 1.4 -2.2
Mouth/teeth dental problems 0.5 0.8 2.6 1.4 0.5 0.2 0.4 1.0 -0.1 0.8 0.5 -1.3 -1.6 0.3
Heart attack 1.7 2.2 4.4 1.8 1.3 1.1 -0.2 2.0 -2.0 1.4 2.1 1.0 -1.7 0.0
Allergy 3.8 8.7 20.2 2.2 0.5 3.2 2.5 2.9 -4.4 1.2 3.6 4.5 -3.5 0.0
Pain all over the body in last month 0.4 0.4 1.1 -0.6 -0.6 -1.0 -0.3 -0.5 -0.2 -0.8 -0.3 0.7 0.5 -0.8
Diabetes (self-reported) 1.8 2.8 5.4 -2.2 -1.6 -1.2 -0.2 -2.1 0.9 -2.3 -1.9 0.4 1.4 -2.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.2 0.0 0.8 0.6 -0.2 0.2 1.7 0.4 -1.1 -1.8 0.0 -0.2
Medication: Ramipril 0.5 0.6 1.5 -0.7 -0.8 -1.2 -1.0 -1.0 0.4 -1.2 -0.0 -0.3 0.3 0.2
Medication: Simvastatin 0.7 1.0 4.6 0.5 0.7 1.1 0.9 0.4 -1.0 0.7 0.7 2.1 -0.4 -1.2
Fluid intelligence score 1.6 3.3 6.0 -1.9 -1.4 -1.4 -0.4 -2.4 2.4 -2.0 -2.1 -1.7 2.3 0.3
Illnesses of siblings 1.0 1.3 3.2 -1.3 0.7 -0.2 0.8 -1.3 1.8 0.4 -1.5 -1.6 1.5 -0.1
Neuroticism score 0.5 1.0 4.8 -0.9 -0.5 -1.1 -2.2 -0.4 0.1 -0.5 0.5 0.6 1.6 0.0
Weight 0.3 1.3 7.1 -0.4 -0.7 -1.2 -0.8 -0.0 1.5 -0.3 0.1 -2.7 0.5 1.5
Impedance of arm (right) 0.4 2.0 11.0 -1.1 -1.1 -2.0 -3.3 -0.8 0.3 -1.0 0.2 -0.5 1.4 0.8
Arm fat percentage (right) 0.1 0.4 1.3 0.3 0.4 -0.7 -0.9 0.7 -0.4 0.8 1.1 -0.1 0.5 -0.3
Trunk fat-free mass 1.0 5.6 17.6 -1.9 -2.1 -1.7 -0.9 -1.7 3.8 -1.9 -2.5 -4.2 1.2 2.0
Hip circumference 0.2 1.0 4.3 0.7 0.2 -0.0 0.3 1.1 0.7 0.5 0.6 -2.1 -0.2 2.0
Time employed in main current job 0.4 0.4 1.6 0.4 -0.7 -0.5 -0.9 0.3 0.1 -0.3 -0.5 0.3 -1.2 1.0
Alcohol intake versus 10 years previously 1.7 2.5 9.1 1.4 0.4 1.3 0.3 0.5 -2.6 -0.1 3.0 2.2 -1.7 -0.1
Father’s age at death 0.7 1.0 4.0 0.9 0.6 1.2 0.8 0.5 0.4 0.8 -0.0 -2.0 -0.5 1.4
Worrier / anxious feelings 1.0 1.9 5.0 1.0 1.4 0.4 -0.4 1.9 -1.5 1.9 1.8 2.2 -0.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 2.9 -1.6 -1.6 -1.4 -1.7 -1.0 0.1 -1.7 -0.6 1.4 1.6 -1.1
Falls in the last year 0.5 0.7 3.5 -1.0 0.0 -0.6 -0.4 -0.4 1.2 -0.4 -1.2 -0.0 1.9 0.0
Hair/balding pattern: Pattern 3 0.1 0.2 0.6 0.4 -0.1 0.2 0.1 0.2 -0.7 0.1 0.2 0.7 -0.3 0.8
Number of live births 1.7 2.4 4.4 -1.5 -1.6 -1.5 -1.7 -1.5 1.2 -1.5 -1.1 -1.5 2.1 1.7
Forced expiratory volume in 1-second (FEV1) 1.6 5.5 16.1 3.3 1.2 1.5 1.7 2.8 -2.2 2.0 2.6 -0.5 -4.0 1.8
Pulse rate 2.8 4.8 8.8 -1.9 -1.8 -2.1 -0.9 -1.9 2.8 -2.2 -3.0 -2.9 1.4 2.3
Happiness 2.4 2.9 6.5 -1.9 -0.8 -1.2 -1.4 -2.3 2.1 -2.0 -2.6 -0.2 1.9 -0.1
Noisy workplace 3.6 4.5 10.4 2.1 2.3 1.7 0.7 1.7 -2.8 2.1 3.2 1.3 -2.0 -2.2
Qualifications: A levels/AS levels or equivalent 0.6 1.3 4.6 -0.2 -0.0 0.0 0.3 -1.5 2.1 -1.4 -2.1 -0.7 0.8 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.4 -0.3 -0.5 -0.8 0.2 -1.3 0.2 -0.9 -0.3 1.6 0.7 -1.0
Mouth/teeth dental problems: Dentures 0.8 1.3 3.5 -1.9 -0.5 -0.7 -0.3 -1.3 0.2 -0.6 -0.5 1.7 1.7 -1.5
Asthma 5.5 10.8 25.4 -2.3 -2.7 -4.4 -2.9 -3.2 3.8 -3.1 -2.5 -5.0 1.8 3.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.9 0.2 -0.3 0.0 1.0 0.8 -0.3 0.4 0.4 -0.4 -0.6 1.7
Medication: Cholesterol lowering 0.3 0.5 2.7 -0.2 -0.0 0.6 0.3 0.1 -0.7 0.1 1.2 1.6 0.0 -0.2
Depression (self-reported) 2.6 3.1 8.1 1.3 1.4 1.1 1.1 0.7 -2.2 1.3 2.7 2.9 -0.8 -2.3
Medication: Lansoprazole 0.7 0.8 2.7 0.1 0.6 0.2 0.2 0.9 -1.2 0.8 1.1 1.7 -0.7 -0.7
Prospective memory result 1.0 1.2 4.0 -0.9 -1.7 -2.0 -1.6 -0.6 0.5 -1.2 -0.6 0.4 0.8 0.3
Lung cancer (father) 1.0 1.2 2.6 0.7 1.3 0.8 0.1 1.5 -1.6 1.2 1.1 1.3 -0.0 -0.9
Illnesses of mother 1.5 1.9 3.9 -1.2 -2.0 -1.9 -1.4 -1.0 0.7 -1.4 -0.5 -1.5 0.4 2.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 6.9 20.4 3.9 1.7 2.2 2.2 2.8 -2.4 2.1 2.6 -0.3 -4.5 1.7
Pulse wave Arterial Stiffness index 1.5 1.7 6.5 -1.7 -0.1 -0.8 -0.9 -1.6 1.6 -0.6 -1.5 -0.5 2.5 -0.6
Impedance of arm (left) 0.2 0.8 4.5 -0.2 0.1 -1.3 -2.1 -0.1 -0.6 0.0 0.9 0.3 0.9 -0.4
Arm fat mass (right) 0.1 0.5 1.6 -0.3 -0.4 -1.1 -1.0 0.2 0.6 0.2 0.5 -1.3 0.7 0.6
Trunk predicted mass 1.0 5.7 17.5 -2.0 -2.0 -1.8 -0.9 -1.8 3.8 -2.0 -2.5 -4.2 1.3 1.9
Standing height 1.3 12.6 39.7 -2.6 -3.2 -3.3 -3.4 -2.2 4.7 -2.9 -2.4 -6.3 1.8 4.0
Length of working week for main job 0.7 0.8 2.8 -0.7 -0.4 -0.8 0.5 -0.8 1.6 -0.6 -1.7 -0.8 0.4 0.1
Exposure to tobacco smoke at home 0.1 0.1 0.5 -0.3 -0.3 0.1 -0.2 0.4 0.1 0.4 0.2 -0.2 -0.3 0.7
Breastfed as a baby 0.5 0.6 1.7 -0.3 0.4 -0.3 0.3 -1.1 0.8 -0.4 -1.3 -0.1 0.6 -1.3
Tense / ‘highly strung’ 0.2 0.4 1.9 -0.2 0.6 0.4 -0.9 -0.1 -0.5 0.3 1.4 0.4 0.4 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 10.8 0.1 0.1 -0.5 -0.5 0.0 -2.9 0.1 3.3 2.8 0.2 -1.2
Hair/balding pattern: Pattern 4 0.3 0.8 2.8 0.5 0.6 1.0 -0.0 0.2 -1.2 0.4 1.5 1.7 0.4 -0.6
Birth weight of first child 0.2 0.4 1.6 -0.4 -1.1 -0.5 -0.5 0.3 -0.4 -0.1 1.2 -0.4 -0.3 0.6
Peak expiratory flow (PEF) 0.5 1.2 3.2 0.9 0.9 0.7 1.1 1.7 -0.7 1.8 1.2 -0.3 -1.3 0.3
Pulse wave reflection index 0.1 0.2 1.3 -0.3 0.4 -0.1 -0.1 0.0 0.0 0.5 0.1 0.3 1.1 0.1
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.4 -1.1 -0.6 -0.9 -0.6 -1.6 0.0 -1.2 -0.2 1.4 1.1 -1.5
Loud music exposure frequency 1.0 1.1 5.4 1.0 1.2 1.2 2.3 0.9 0.3 0.4 -0.5 0.4 -1.0 0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 4.7 -0.7 -0.7 -0.4 0.3 -1.1 2.1 -0.9 -2.2 -1.1 0.8 0.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 2.0 -0.3 0.7 0.6 0.6 0.4 0.0 0.2 -0.3 1.4 1.1 -0.1
Blood clot in the leg (DVT) 0.9 1.2 6.8 -0.1 -1.0 -0.8 -2.6 -0.3 -0.8 -0.8 1.2 0.9 0.8 -0.3
Medication: Paracetamol 1.5 2.4 5.1 1.3 1.7 -0.2 1.5 1.8 -2.0 1.8 1.3 2.3 -1.2 -1.2
Headache pain in last month 0.3 0.4 1.6 0.7 -0.4 -1.3 0.0 0.5 -0.0 -0.1 -0.2 -0.4 -1.0 1.1
Medication for cholesterol, blood pressure or diabetes 1.1 1.7 3.5 1.9 1.8 1.2 1.2 1.3 -0.6 1.6 0.5 -1.7 -1.4 0.2
Glaucoma (self-reported) 0.3 0.4 1.4 -0.9 -0.5 -1.2 -0.7 -0.7 -0.2 -0.2 0.1 -0.1 0.7 -0.7
Gout (self-reported) 3.3 4.5 7.2 1.9 2.1 2.7 2.7 2.3 -1.9 2.4 1.9 2.3 -1.5 -1.2
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 6.5 -1.6 -0.8 -1.4 -2.2 -2.1 1.9 -1.0 -1.4 -1.8 2.5 -0.5
Medication: Amlodipine 0.3 0.4 1.0 -1.0 -0.3 -0.6 0.3 -0.9 0.5 0.2 -0.6 -0.3 0.7 -1.0
Medication: Ventolin 100micrograms inhaler 4.4 5.7 14.5 -2.2 -1.6 -3.8 -3.0 -2.5 2.6 -1.7 -1.6 -2.8 1.7 1.4
Birth weight 0.4 0.8 1.8 1.2 0.9 0.4 0.3 1.1 0.1 0.8 -0.3 -1.4 -1.3 0.6
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.6 0.0 -0.6 -0.7 -0.8 -0.5 0.3 -0.7 0.5 -0.7 -0.2 0.7
High blood pressure (siblings) 0.4 0.6 1.4 1.0 0.1 -0.5 -0.6 1.1 -1.0 0.4 1.2 1.0 -1.0 -0.1
Forced vital capacity (FVC), Best measure 2.1 7.7 22.7 4.1 1.7 2.3 2.5 2.6 -2.3 1.8 3.1 -0.9 -4.8 2.2
Body fat percentage 0.2 0.8 3.2 0.7 0.6 -0.4 -0.5 1.3 -1.1 1.1 1.8 -0.1 0.3 0.0
Leg fat percentage (right) 0.3 1.2 3.7 1.0 0.7 0.3 0.3 1.7 -1.7 1.2 1.9 0.7 -0.2 -0.5
Arm fat-free mass (right) 0.4 2.2 9.9 -0.7 -1.2 -0.9 -0.1 -0.4 2.3 -0.9 -1.1 -3.1 0.3 1.9
Exposure to tobacco smoke outside home 0.2 0.2 0.5 -0.5 0.2 -0.5 -0.1 -0.7 0.7 -0.4 -0.5 -0.5 0.3 -0.2
Comparative body size at age 10 0.8 2.1 6.2 1.5 0.6 0.5 1.0 1.4 -2.0 0.5 1.1 2.5 -1.5 -1.9
Number of full brothers 2.2 2.7 6.3 2.5 1.0 1.2 1.2 2.1 -2.0 1.6 1.6 0.5 -2.4 -0.4
Worry too long after embarrassment 0.4 0.7 4.5 0.4 0.0 -0.2 -0.8 0.8 0.6 0.1 -0.4 -1.1 0.2 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 4.1 -1.7 -0.8 -1.2 -1.5 -1.7 -0.9 -1.4 1.0 2.0 1.5 -2.0
Wheeze or whistling in the chest in last year 0.5 0.8 1.9 -1.0 0.6 -0.7 -1.0 -1.4 -0.1 0.1 1.1 -0.8 0.8 -1.3
Number of children fathered 2.5 2.8 6.6 2.1 0.4 1.6 0.1 2.0 -0.8 1.7 1.3 -2.0 -2.6 2.1
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 6.6 -1.7 -2.2 -2.6 -1.5 -1.4 -0.1 -1.7 0.5 -0.3 0.8 -0.6
Age at first live birth 0.9 1.6 3.5 -1.2 -0.8 -0.2 -0.3 -1.4 1.9 -1.6 -1.7 -1.9 0.7 -0.3
Pulse wave peak to peak time 1.2 1.5 6.1 1.6 -0.0 0.7 0.7 1.5 -1.3 0.4 1.3 0.0 -2.5 0.8
Health satisfaction 1.9 2.5 6.2 -1.6 -2.0 -1.0 -1.4 -1.5 1.6 -2.5 -1.5 -1.6 1.2 0.9
Shortness of breath walking on level ground 0.8 1.0 1.6 -0.8 -1.0 -1.0 -0.7 -1.0 1.2 -1.1 -0.5 -1.3 0.8 1.3
Qualifications: College or University degree 0.9 2.8 6.4 -1.8 -0.7 -0.6 1.2 -2.5 2.4 -1.5 -2.3 -1.0 2.1 -0.5
Eye problems/disorders: None of the above 1.6 1.8 3.0 1.7 1.4 0.8 1.3 1.0 -1.5 1.4 1.2 1.4 -1.5 -1.2
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.0 -1.1 -1.1 -0.1 -0.8 -1.3 1.0 -1.4 -1.0 -0.9 0.6 0.4
Emphysema/chronic bronchitis 4.1 4.6 7.9 1.8 2.7 2.3 1.4 2.2 -2.8 2.4 2.3 1.9 -1.1 -2.0
Medication for pain relief, constipation, heartburn 2.5 4.2 6.7 -2.1 -2.2 -0.6 -2.1 -2.4 2.6 -2.4 -2.4 -1.5 2.4 0.6
Neck or shoulder pain in last month 1.0 1.4 5.7 -0.4 0.8 -0.3 0.3 0.6 -1.7 0.4 1.5 2.4 0.1 -1.9
Medication: Blood pressure 0.9 1.5 3.1 -1.8 -1.5 -0.7 -0.7 -1.2 0.6 -1.5 -0.7 1.6 1.5 -0.8
Angina (self-reported) 0.5 0.6 1.7 0.9 0.8 0.9 0.4 1.3 -0.7 0.6 0.6 1.1 -0.4 -0.3
Migraine (self-reported) 0.4 0.6 2.0 0.7 0.0 -0.5 0.2 0.6 -0.8 0.5 0.5 1.4 -1.0 -0.9
Medication: Ibuprofen 0.3 0.4 2.6 0.2 -0.1 -0.0 0.9 0.4 -0.1 0.2 0.4 -0.6 -0.3 1.6
Medication: Allopurinol 1.2 1.6 4.1 1.1 1.2 1.9 2.0 1.6 -0.7 1.4 0.8 0.8 -0.7 -0.2
Medication: Omeprazole 0.4 0.5 1.3 0.1 0.3 -0.9 0.8 0.8 -0.9 0.6 1.1 0.4 -0.6 0.5
Medication: Seretide 50 evohaler 0.3 0.3 0.8 0.0 0.1 -0.3 0.8 0.9 -0.8 0.6 0.6 0.6 -0.5 0.5
Mean time to correctly identify matches 2.2 4.1 9.7 1.3 1.9 2.2 0.7 1.1 -2.9 1.6 3.1 3.1 -0.6 -1.7
Heart disease (mother) 0.5 0.6 2.2 0.4 0.2 0.6 0.3 1.0 -1.0 0.6 0.9 1.5 0.2 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.5 0.8 1.0 -0.2 0.3 1.4 -1.6 1.9 1.2 1.1 -0.4 -0.8
Whole body fat mass 0.1 0.5 2.2 -0.0 -0.2 -1.0 -0.8 0.6 0.2 0.3 0.8 -1.5 0.5 0.9
Leg fat mass (right) 0.1 0.3 1.3 0.3 0.0 -0.4 -0.0 1.0 -0.4 0.5 1.1 -0.7 0.1 0.4
Arm predicted mass (right) 0.4 2.2 9.0 -0.9 -1.2 -1.0 0.1 -0.6 2.4 -0.9 -1.3 -3.0 0.6 1.6
Pulse rate, automated reading 0.3 1.0 2.6 -1.1 -0.9 -1.2 -0.4 -1.1 1.1 -1.0 -1.6 -0.1 1.2 0.4
Alcohol intake frequency. 0.6 1.3 6.5 0.8 0.3 0.2 -1.2 0.6 -1.4 -0.3 1.3 2.6 -1.2 -0.6
Comparative height size at age 10 0.1 0.5 1.2 -0.6 -0.8 -0.2 -1.1 0.4 0.1 -1.0 0.7 -1.0 0.5 0.7
Number of full sisters 0.6 0.7 2.2 1.3 0.7 1.1 0.4 0.2 -0.6 0.1 1.1 -0.5 -1.5 0.4
Suffer from ‘nerves’ 0.4 0.6 2.3 -0.5 0.6 0.3 0.2 0.7 -0.5 0.7 -0.1 1.5 0.8 -1.3
Overall health rating 0.8 1.7 3.9 -2.0 -1.4 -1.3 -2.0 -1.0 -0.2 -1.4 0.2 0.6 1.9 -1.0
Chest pain or discomfort 1.3 1.8 4.6 0.8 1.0 1.2 -0.1 0.7 -1.9 0.8 2.1 1.8 -1.2 -1.6
Had major operations 0.9 1.1 3.7 0.5 0.0 0.0 0.1 0.7 -1.2 -0.1 0.8 1.9 -1.4 -1.7
Age at last live birth 0.3 0.4 2.0 0.3 0.3 0.9 0.9 -0.0 -0.0 -0.2 -0.1 -0.3 -0.9 -1.4
Family relationship satisfaction 2.2 2.7 6.4 -2.0 -0.8 -1.0 -1.4 -1.9 1.9 -1.7 -2.4 0.0 2.5 -0.6
Leg pain on walking 1.3 1.6 2.9 -1.5 -1.7 -1.1 -1.3 -1.2 1.1 -1.6 -0.6 -0.7 1.6 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.0 0.6 -0.3 -0.1 -0.7 0.8 -0.2 -0.3 1.0 -1.4 -1.4 1.2
Commuting to job workplace: Car/motor vehicle 1.7 1.9 4.4 1.3 1.4 2.0 0.7 1.4 -1.0 1.9 2.1 -0.5 -1.2 0.7
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 5.6 0.9 0.9 0.6 0.2 1.0 0.2 1.4 0.6 -2.4 -1.7 1.5
Medication: Aspirin 1.1 1.5 2.6 1.1 1.6 1.0 0.7 1.2 -1.4 1.2 1.2 1.5 -0.4 -1.6
Supplements: Vitamin C 0.4 0.4 1.4 0.8 0.2 -0.4 -0.7 0.5 -0.8 0.3 1.2 -0.2 -0.5 0.7
Knee pain experienced in last month 0.2 0.3 1.3 -0.6 0.2 -0.9 -0.3 -0.1 0.2 0.8 0.6 -0.3 1.2 -0.1
Hypertension (Self-reported) 0.3 0.9 1.9 -1.4 -0.0 -1.0 -0.1 -0.5 1.1 -0.3 -1.1 1.0 1.3 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 -0.3 0.2 -0.2 0.3 -0.3 0.7 -0.1 -0.6 -1.1 -0.2 1.0
Illnesses of father: Heart disease 0.4 0.6 1.4 0.5 -0.6 0.3 -0.7 0.9 -1.0 0.5 1.2 0.9 -0.8 0.2
Illnesses of siblings: Diabetes 0.4 0.6 1.8 0.3 -0.8 0.6 0.2 0.9 -1.3 -0.5 0.8 0.9 -0.8 0.1
Smoking status: Previous 3.0 4.5 9.4 2.4 2.4 1.4 1.6 2.0 -2.4 2.4 3.1 0.6 -2.4 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.2 12.8 -1.6 -2.4 -2.5 -1.8 -2.4 3.2 -1.9 -2.0 -3.6 0.6 1.6
Whole body fat-free mass 1.0 5.6 18.0 -1.8 -2.2 -2.0 -1.3 -1.7 3.5 -1.9 -2.1 -4.2 1.1 2.2
Leg fat-free mass (right) 0.9 5.1 16.2 -1.7 -2.0 -2.4 -1.8 -1.5 3.2 -1.7 -1.7 -4.0 1.1 2.1
Arm fat percentage (left) 0.2 0.8 2.1 0.7 1.0 -0.4 -0.4 1.0 -0.9 1.3 1.4 0.4 0.4 -0.9
Average weekly red wine intake 0.7 1.0 3.6 -1.4 -0.6 0.1 -0.4 -1.2 0.6 -1.0 -0.4 -0.7 1.9 -1.1
Handedness (chirality/laterality): Left-handed 0.6 0.8 2.3 -0.4 -1.5 -0.9 -1.1 -0.2 0.2 -1.4 -0.2 -0.1 0.3 1.3
Mood swings 0.2 0.3 0.7 0.0 0.5 0.8 -0.3 0.4 -0.5 0.5 0.9 0.6 0.6 -0.4
Loneliness, isolation 1.5 2.1 5.8 -1.4 -0.7 -1.0 -2.4 -1.0 -1.2 -0.6 1.6 1.3 1.3 -2.1
Long-standing illness, disability or infirmity 0.7 1.1 2.7 1.0 1.4 1.4 1.6 1.1 -0.4 1.0 0.7 0.2 -1.1 -0.7
Ever had bowel cancer screening 0.4 0.5 1.8 -0.4 -0.5 -0.9 -1.1 -0.1 -0.0 -0.7 0.5 -0.7 -0.0 1.4
Diabetes diagnosed by doctor 1.6 2.7 6.1 -2.1 -1.6 -1.1 -0.3 -1.9 0.6 -2.5 -1.7 1.0 1.2 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.9 0.2 -0.3 -1.0 -0.6 0.2 0.3 0.2 -0.2 0.1 -0.3 -0.1
Friendships satisfaction 1.0 1.2 3.8 -1.6 -0.8 -0.6 -0.1 -1.6 0.8 -1.1 -1.1 0.5 1.9 -0.2
Qualifications: nursing, teaching 1.2 1.9 3.8 1.2 0.9 1.6 1.9 1.1 -1.4 1.2 2.0 1.1 -1.5 -0.6
Commuting to job workplace: Walk 0.1 0.1 0.5 -0.0 0.0 -0.7 -0.0 -0.7 0.3 -0.3 0.1 0.1 -0.4 0.1
Eye problems/disorders: Cataract 0.7 0.8 2.5 -0.5 -1.6 -0.6 -0.7 -0.3 0.7 -1.5 -0.3 -0.7 -0.1 1.5
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.4 0.3 0.1 0.2 -0.5 0.3 -0.5 -0.0 0.4 0.6 0.2 0.1
Medication for cholesterol 0.3 0.5 1.8 1.0 0.0 0.4 1.3 0.0 -1.0 0.2 1.2 -0.1 -0.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.3 0.6 0.0 -0.2 -0.4 -0.2 -0.3 -0.1 0.7 -1.1 -0.8 0.0
Back pain experienced in last month 1.9 2.8 7.6 1.4 1.0 1.2 1.5 1.3 -2.8 0.8 2.7 1.7 -2.0 -0.4
Mineral and other dietary supplements 0.9 1.2 2.5 -0.8 -1.0 -1.6 -1.0 -0.3 0.9 -1.5 -1.4 -1.5 0.5 -0.1
Breast cancer (self-reported) 0.8 0.9 2.4 -1.6 -0.6 -1.0 -0.3 -1.1 0.9 -1.2 -1.0 -0.7 1.0 -0.3
Asthma (self-reported) 4.8 9.5 23.4 -2.1 -2.3 -4.1 -2.6 -3.1 3.6 -2.8 -2.4 -4.8 1.7 2.9
Osteoporosis (self-reported) 2.3 2.9 6.2 1.7 1.3 0.7 0.6 2.2 -2.3 1.0 2.2 2.5 -2.2 -0.5
Osteoarthritis (self-reported) 2.1 2.7 5.3 1.8 1.8 1.5 0.5 1.6 -2.0 2.0 2.3 1.7 -1.5 -0.7
Medication: Aspirin 0.9 1.1 2.2 1.0 1.4 0.9 0.4 1.2 -1.1 1.2 1.0 1.1 -0.3 -1.5
Medication: Gliclazide 0.9 1.0 2.9 -1.3 -0.5 -1.1 0.0 -1.7 0.5 -0.9 -1.2 -0.5 0.4 -1.5
Illnesses of father: None of the above (group 1) 0.1 0.1 0.5 0.0 0.3 0.7 0.2 -0.5 0.1 -0.4 -0.2 -0.5 -0.1 0.1
Smoking status: Current 0.6 0.9 2.0 -0.4 -1.4 0.0 -0.9 -0.8 -1.2 -1.3 1.0 1.4 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.1 8.6 20.0 3.3 1.6 2.5 2.1 3.2 -4.5 2.4 3.9 2.7 -3.4 -0.9
Whole body water mass 1.0 5.5 17.4 -1.8 -2.2 -2.0 -1.3 -1.7 3.6 -1.9 -2.1 -4.2 1.1 2.2
Leg predicted mass (right) 1.0 5.3 16.6 -1.7 -2.0 -2.4 -1.9 -1.5 3.2 -1.7 -1.8 -4.1 1.1 2.1
Arm fat mass (left) 0.1 0.3 1.2 -0.0 0.0 -0.8 -0.6 0.4 0.4 0.4 0.6 -1.1 0.6 0.2
Number of self-reported non-cancer illnesses 0.6 1.0 3.6 -0.4 1.4 0.5 0.6 0.1 -0.7 0.8 0.9 1.8 0.3 -1.9
Average weekly champagne plus white wine intake 0.6 0.8 2.9 0.2 0.7 0.4 1.0 -0.2 1.2 0.5 -1.7 -1.2 0.4 0.1
Miserableness 0.4 0.7 3.1 -0.2 -0.2 -0.5 -1.0 -0.1 -1.0 0.0 1.1 1.8 0.9 -0.9
Guilty feelings 0.6 0.9 2.3 0.7 0.6 1.1 -0.6 1.1 -1.3 0.7 1.2 1.5 0.1 -0.0
Wears glasses or contact lenses 0.5 0.6 1.2 -0.7 -0.6 -1.1 -1.1 -0.6 0.6 -0.9 -0.6 -0.2 0.4 1.0
Ever taken oral contraceptive pill 0.2 0.3 1.2 -0.2 0.1 -0.6 0.7 0.1 0.8 -0.0 -1.1 0.4 -0.4 0.1
Hearing aid user 0.9 1.1 3.9 0.9 0.7 0.2 0.7 0.6 -1.3 0.2 1.8 0.8 -2.0 0.1
Mother’s age at death 0.1 0.2 0.8 -0.2 0.4 0.0 -0.1 -0.9 0.4 0.0 0.0 0.2 0.6 -0.5
Financial situation satisfaction 0.2 0.2 0.8 -0.4 0.2 -0.5 -0.9 -0.3 0.2 -0.5 -0.2 -0.5 -0.2 -0.5
Tinnitus: Yes, now most or all of the time 1.2 1.4 6.5 0.2 -1.2 -0.3 -1.8 0.3 0.7 -1.0 -0.7 -1.5 -0.4 2.5
Commuting to job workplace: Public transport 2.9 3.5 6.1 -2.1 -1.7 -2.2 -1.4 -2.2 1.9 -2.2 -2.5 0.3 2.0 -0.6
Eye problems/disorders: Glaucoma 0.2 0.2 0.9 -0.1 0.5 -0.1 0.1 0.1 -0.5 0.7 0.3 -0.5 0.1 -1.0
Medication: Blood pressure 0.2 0.4 1.3 -0.8 0.4 -0.4 -1.0 -0.2 1.2 -0.2 -1.0 -0.4 0.5 -0.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 5.3 -1.1 0.3 -1.0 -0.6 0.3 -1.5 0.4 1.4 2.3 0.6 -2.2
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.9 0.8 0.3 1.3 0.6 0.3 -0.3 1.1 0.8 0.0 -0.7 1.4
High cholesterol (Self-reported) 1.4 2.4 14.2 0.3 0.3 0.8 1.2 1.1 -2.1 0.7 1.7 3.8 -0.1 -1.2
Medication: Bendroflumethiazide 0.2 0.4 1.2 -0.1 0.7 0.7 0.2 0.5 1.1 0.2 -1.0 0.2 0.3 0.3
Medication: Paracetamol 1.6 2.4 4.3 1.5 1.7 -0.2 1.7 2.1 -1.7 2.0 1.4 1.8 -1.4 -0.4
Medication: Lisinopril 0.6 0.8 1.7 -0.7 -1.2 -0.4 -0.6 -0.7 1.0 -1.3 -1.1 -0.1 0.8 1.0
Medication: Atorvastatin 1.0 1.2 2.8 -1.6 -1.2 -1.0 -1.3 -1.0 -0.3 -0.8 0.4 1.2 1.7 -0.7
Illnesses of father: High blood pressure 0.7 0.8 3.1 1.2 0.8 0.7 0.4 0.9 0.1 1.1 -0.4 0.3 -0.9 -1.8
Alcohol drinker status: Never 0.4 0.4 2.1 0.9 0.7 -0.4 -0.4 0.6 -0.5 0.2 -0.1 0.6 -1.4 0.2
Ever smoked 1.6 2.9 7.8 1.8 1.8 1.5 1.3 1.3 -2.4 1.8 2.8 0.7 -1.6 -0.7
Basal metabolic rate 0.8 4.6 15.8 -1.7 -2.0 -1.9 -1.3 -1.4 3.2 -1.7 -1.7 -4.0 1.1 2.0
Leg fat percentage (left) 0.4 1.4 3.6 1.1 1.0 0.2 0.3 1.8 -1.8 1.4 1.9 0.9 -0.0 -0.6
Arm fat-free mass (left) 0.6 3.0 11.5 -1.1 -1.6 -1.0 -0.6 -0.8 2.6 -1.3 -1.2 -3.4 0.5 2.2
Number of operations (self-reported) 4.0 6.0 15.3 1.6 2.3 1.9 1.2 1.9 -2.6 2.1 2.4 3.9 -1.9 -3.7
Average weekly beer plus cider intake 0.5 0.7 4.1 0.4 -0.3 -1.1 -0.6 0.1 0.0 0.0 0.3 -2.0 -1.2 0.8
Irritability 0.1 0.1 0.4 0.6 0.3 -0.3 0.3 0.2 0.4 -0.0 -0.1 -0.6 0.0 0.6
Risk taking 0.2 0.2 0.6 0.1 -0.2 0.2 -0.8 -0.3 -0.2 -0.7 0.1 -0.5 -0.8 -0.5
Ever had prostate specific antigen (PSA) test 1.0 1.2 4.0 -0.8 -0.1 -0.6 -0.4 -0.7 0.6 -0.6 -1.4 1.2 2.0 -1.9
Fractured/broken bones in last 5 years 0.4 0.6 2.3 -0.6 0.6 0.7 1.5 -0.1 0.5 0.9 -0.7 0.7 0.4 -0.6
Age started oral contraceptive pill 0.6 0.8 2.6 0.4 0.2 -0.4 -1.6 0.1 -0.0 0.4 0.7 -1.6 -1.0 1.3
Diastolic blood pressure, automated reading 0.4 1.2 3.8 -0.9 1.0 0.0 0.3 0.2 1.6 1.4 -1.4 -1.9 0.0 0.6
Ever depressed for a whole week 1.3 1.6 4.9 -1.2 0.4 -0.3 1.5 -0.8 -0.7 -0.1 0.6 2.1 1.6 -2.2
Unable to work because of sickness or disability 0.6 0.7 1.9 1.1 0.2 1.4 0.7 0.7 -1.1 0.4 0.6 0.9 -1.1 -0.5
Commuting to job workplace: Cycle 0.7 0.8 2.7 -1.2 0.3 -0.7 1.6 -0.8 0.5 -0.4 -0.8 0.1 1.1 -1.1
Myopia 1.9 2.8 4.4 -1.5 -1.5 -1.3 -1.9 -1.9 1.8 -1.9 -2.1 -2.0 1.6 0.5
Vascular/heart problems diagnosed by doctor 0.2 0.5 2.6 0.6 -0.5 0.0 -0.5 -0.2 -0.2 -0.4 0.1 -1.6 -0.5 1.1
Cholesterol lowering medication 0.8 1.2 4.6 0.2 1.0 0.8 1.3 1.0 -0.9 1.1 0.3 2.1 0.5 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.7 0.4 1.4 -0.1 1.1 1.3 -1.1 1.6 1.3 0.7 -0.4 -0.8
Pain experienced in last month 0.2 0.3 1.9 0.7 0.1 1.4 0.2 -0.2 -0.3 0.1 0.3 0.4 -0.6 -0.5
Supplements: Calcium 0.2 0.3 1.1 -0.2 0.4 -0.4 -0.4 -1.0 0.1 -0.4 -0.1 -0.3 0.2 -1.0
Basal cell carcinoma (self-reported) 0.4 0.5 1.5 0.4 -0.7 0.6 -1.2 -0.5 -0.2 -0.2 1.2 -0.9 -0.5 0.8
Heart attack/myocardial infarction (self-reported) 1.0 1.2 2.4 1.5 1.1 0.7 -0.5 1.6 -1.4 1.0 1.4 0.6 -1.3 0.1
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 5.6 -0.2 -0.8 -0.5 -2.4 -0.4 -0.9 -0.8 1.2 1.2 0.9 -0.6
Heart disease (siblings) 0.3 0.3 1.0 0.1 -0.3 0.8 -0.5 0.8 -1.0 0.1 0.3 1.0 -0.1 -0.3
Alcohol drinker status: Previous 1.2 1.4 8.0 0.7 0.6 0.9 0.5 0.7 -1.2 0.7 0.5 2.8 0.4 -1.5
Pack years of smoking 0.3 0.5 1.4 -0.9 -0.3 0.1 -0.2 -1.2 0.3 -1.2 -0.3 0.6 0.5 -0.8
Impedance of whole body 0.2 0.8 2.8 0.4 0.7 -0.1 -0.8 0.9 -1.7 0.7 1.6 1.1 0.4 -0.4
Leg fat mass (left) 0.1 0.3 0.8 0.2 0.0 -0.6 -0.1 0.9 -0.2 0.4 0.8 -0.9 0.3 0.5
Arm predicted mass (left) 0.5 2.6 11.0 -0.8 -1.5 -1.1 -0.4 -0.5 2.4 -1.1 -1.0 -3.3 0.2 2.2