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chr14:54,715,845-56,575,157

Best TWAS P=1.93e-14 · Best GWAS P=5.86e-12 conditioned to 0.195

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	METSIM	Adipose	ATG14	0.05	0.06	lasso	3	0.07	4.5e-10	6.8	7.7	1.9e-14	0.80	0.02	0.98	TRUE
9	GTEx	Pituitary	LGALS3	0.40	0.34	enet	20	0.43	3.5e-12	6.8	-6.8	8.0e-12	-0.97	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA0831	0.03	0.04	lasso	1	0.03	2.1e-04	6.8	-6.8	1.5e-11	-1.00	0.02	0.94	FALSE
15	YFS	Blood	FBXO34	0.04	0.05	lasso	10	0.05	2.2e-15	6.8	6.6	4.6e-11	0.96	0.02	0.98	FALSE
11	GTEx	Skin Sun Exposed Lower leg	ATG14	0.10	0.10	lasso	3	0.15	1.0e-12	5.5	-6.0	2.6e-09	-0.77	0.95	0.05	FALSE
7	GTEx	Esophagus Mucosa	ATG14	0.13	0.13	lasso	9	0.17	1.2e-11	5.5	-5.9	4.8e-09	-0.86	0.44	0.56	FALSE
8	GTEx	Esophagus Mucosa	WDHD1	0.10	0.01	enet	16	0.03	3.4e-03	5.5	5.8	6.6e-09	0.67	0.12	0.49	FALSE
13	GTEx	Thyroid	FBXO34	0.12	0.09	lasso	6	0.10	4.3e-08	5.5	-5.8	6.8e-09	-0.90	0.06	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FBXO34	0.05	0.10	lasso	4	0.09	2.5e-11	5.5	-5.8	7.7e-09	-0.84	0.72	0.28	FALSE
4	CommonMind	Brain Pre-frontal Cortex	WDHD1	0.06	0.09	enet	24	0.09	5.7e-11	4.9	-5.7	9.9e-09	-0.75	0.76	0.24	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA0831	0.02	0.04	lasso	1	0.04	2.2e-05	5.6	-5.6	1.7e-08	-0.80	0.16	0.38	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	ATG14	0.13	0.08	lasso	7	0.07	1.8e-04	5.5	-5.6	1.8e-08	-0.84	0.10	0.83	FALSE
5	GTEx	Adrenal Gland	LGALS3	0.19	0.17	lasso	2	0.12	3.0e-05	5.5	-5.5	3.0e-08	-0.80	0.21	0.73	FALSE
6	GTEx	Cells Transformed fibroblasts	MAPK1IP1L	0.05	0.05	lasso	1	0.02	8.7e-03	5.5	5.5	3.6e-08	0.84	0.10	0.74	FALSE
16	The Cancer Genome Atlas	Esophageal Carcinoma	KIAA0831	0.10	0.05	blup	66	0.04	1.9e-02	5.5	-5.5	4.6e-08	-0.85	0.05	0.39	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATG14	0.03	0.02	blup	438	0.02	7.6e-04	5.5	5.5	4.8e-08	0.79	0.47	0.51	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA0831	0.03	0.03	blup	63	0.02	1.2e-03	5.3	-5.4	5.8e-08	-0.85	0.06	0.76	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	FBXO34	0.02	0.02	blup	95	0.02	2.4e-03	5.6	5.3	1.3e-07	0.83	0.08	0.70	FALSE
12	GTEx	Testis	ATG14	0.12	0.16	lasso	4	0.15	3.4e-07	5.7	-5.2	2.0e-07	-0.82	0.62	0.35	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SOCS4	0.04	0.03	enet	7	0.03	6.3e-04	5.7	-5.2	2.2e-07	-0.50	0.00	0.92	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LGALS3	0.03	0.03	blup	421	0.02	1.2e-03	5.5	-5.2	2.3e-07	-0.77	0.22	0.73	FALSE