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chr15:50,023,520-52,091,785

Best TWAS P=1.51e-21 · Best GWAS P=6.81e-20 conditioned to 0.0385

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Lung	SPPL2A	0.08	0.08	lasso	4	0.07	6.0e-06	-8.9	-9.5	1.5e-21	0.38	0.06	0.92	TRUE
5	GTEx	Brain Cerebellar Hemisphere	TRPM7	0.28	0.06	enet	17	0.03	7.0e-02	5.3	6.0	2.1e-09	-0.72	0.14	0.49	TRUE
12	GTEx	Heart Atrial Appendage	SPPL2A	0.07	0.10	lasso	3	0.09	6.5e-05	-9.0	-9.3	1.1e-20	0.71	0.04	0.90	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	SPPL2A	0.22	0.13	lasso	1	0.09	9.4e-04	-9.1	-9.1	8.8e-20	0.67	0.01	0.77	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	SPPL2A	0.07	0.06	lasso	2	0.05	9.3e-07	-9.0	-9.1	1.3e-19	0.67	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPPL2A	0.43	0.35	enet	9	0.34	2.1e-14	-9.0	-9.0	1.8e-19	0.62	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP4E1	0.02	0.02	lasso	3	0.01	9.5e-04	-8.9	-9.0	2.2e-19	0.28	0.01	0.98	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100132724	0.03	0.01	blup	31	0.01	1.9e-02	-8.8	-9.0	2.9e-19	0.48	0.01	0.88	FALSE
11	GTEx	Esophagus Muscularis	SPPL2A	0.19	0.13	lasso	5	0.11	2.8e-07	-9.0	-8.8	1.1e-18	0.61	0.02	0.98	FALSE
16	GTEx	Nerve Tibial	SPPL2A	0.12	0.10	lasso	4	0.09	4.8e-07	-9.0	-8.7	3.6e-18	0.58	0.02	0.98	FALSE
19	YFS	Blood	USP8	0.02	0.01	blup	426	0.01	2.4e-05	-7.9	-8.1	5.0e-16	0.77	0.06	0.92	FALSE
8	GTEx	Breast Mammary Tissue (Male)	USP8	0.05	-0.01	enet	9	-0.01	5.6e-01	3.3	-7.8	8.7e-15	0.64	0.04	0.16	FALSE
10	GTEx	Esophagus Muscularis	USP8	0.13	0.00	enet	37	0.08	2.5e-05	-6.6	-7.7	1.5e-14	0.32	0.10	0.56	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP4E1	0.04	0.01	enet	20	0.02	2.2e-03	-8.7	-7.2	6.8e-13	0.40	0.02	0.79	FALSE
7	GTEx	Breast Mammary Tissue	USP8	0.15	0.05	lasso	7	0.09	2.2e-05	3.6	-7.0	2.3e-12	0.53	0.09	0.42	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100132724	0.02	0.01	lasso	3	0.01	1.6e-03	-8.2	-6.9	4.8e-12	0.11	0.05	0.71	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TRPM7	0.06	0.03	bslmm	416	0.06	2.8e-08	-4.0	-6.9	5.5e-12	0.25	0.16	0.84	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	SPPL2A	0.25	0.17	blup	39	0.24	7.3e-23	-9.1	-6.7	2.6e-11	0.22	0.01	0.99	FALSE
15	GTEx	Muscle Skeletal	SPPL2A	0.09	0.04	lasso	5	0.06	1.4e-06	-9.0	-6.6	4.0e-11	0.28	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPPL2A	0.14	0.03	lasso	6	0.08	1.5e-16	-9.1	-6.5	1.1e-10	0.25	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPPL2A	0.32	0.07	enet	9	0.16	2.2e-16	-9.1	-6.4	1.3e-10	0.11	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	SPPL2A	0.12	0.05	blup	39	0.04	2.6e-03	-9.0	-6.2	5.5e-10	0.21	0.01	0.77	FALSE
4	GTEx	Artery Tibial	SPPL2A	0.12	0.05	enet	14	0.12	1.1e-09	-4.9	-5.9	4.4e-09	0.22	0.14	0.86	FALSE
3	GTEx	Artery Tibial	USP8	0.14	0.06	lasso	6	0.11	3.3e-09	2.6	-5.8	6.0e-09	0.50	0.74	0.18	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TNFAIP8L3	0.12	0.07	blup	462	0.09	1.2e-10	4.2	5.7	9.5e-09	-0.12	0.99	0.01	FALSE
18	NTR	Blood	AP4E1	0.02	0.00	blup	499	0.01	7.7e-05	5.8	-5.6	1.8e-08	0.53	0.24	0.25	FALSE
14	GTEx	Muscle Skeletal	TRPM7	0.08	0.05	lasso	7	0.07	4.4e-07	5.3	5.6	2.1e-08	-0.64	0.42	0.56	FALSE
17	METSIM	Adipose	SPPL2A	0.11	0.03	blup	426	0.08	1.5e-12	1.2	-5.6	2.3e-08	0.07	0.40	0.60	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TNFAIP8L3	0.03	0.00	blup	41	0.01	8.3e-03	-4.0	-5.3	9.0e-08	0.10	0.01	0.33	FALSE
6	GTEx	Brain Cerebellum	TRPM7	0.17	0.14	lasso	3	0.13	1.3e-04	5.3	5.3	1.2e-07	-0.61	0.30	0.25	FALSE
9	GTEx	Cells Transformed fibroblasts	SPPL2A	0.28	0.11	enet	23	0.31	9.9e-24	-1.4	-5.2	1.9e-07	0.04	0.14	0.86	FALSE