Hub : Genes

TRPM7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0630	0.0200	3.6e-06	0.032	0.064	0.063	0.064	0.058	7.3e-05	2.8e-08	4.0e-08	2.8e-08	1.3e-07
2	GTEx	Brain Cerebellar Hemisphere	0.2780	0.1100	6.9e-04	0.056	NA	0.027	NA	0.020	1.5e-02	NA	7.0e-02	NA	1.0e-01
3	GTEx	Brain Cerebellum	0.1740	0.0710	9.1e-04	0.143	NA	0.106	NA	0.128	5.2e-05	NA	5.0e-04	NA	1.3e-04
4	GTEx	Cells Transformed fibroblasts	0.1090	0.0510	4.1e-03	0.000	NA	0.001	NA	-0.003	2.9e-01	NA	2.6e-01	NA	7.0e-01
5	GTEx	Muscle Skeletal	0.0798	0.0285	9.9e-06	0.054	NA	0.060	NA	0.066	5.2e-06	NA	1.5e-06	NA	4.4e-07
6	METSIM	Adipose	0.0476	0.0200	1.7e-03	0.000	0.026	0.015	0.024	0.002	3.9e-01	7.1e-05	2.3e-03	1.5e-04	1.2e-01
7	TCGA	Esophageal Carcinoma	0.1920	0.1000	1.4e-03	0.024	0.050	0.056	NA	0.034	5.6e-02	1.1e-02	7.3e-03	NA	2.9e-02
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0377	0.0241	8.5e-03	-0.001	0.005	0.012	NA	0.000	4.6e-01	8.6e-02	1.5e-02	NA	3.2e-01
9	TCGA	Brain Lower Grade Glioma	0.0267	0.0153	5.2e-04	0.041	0.030	0.030	NA	0.034	1.6e-05	1.9e-04	2.2e-04	NA	9.2e-05
10	TCGA	Prostate Adenocarcinoma	0.0300	0.0201	1.5e-03	0.035	0.025	0.011	NA	0.031	1.4e-04	1.1e-03	2.4e-02	NA	3.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.8	1.3	3.5	0.7	-1.1	-1.0	0.6	-1.1	-1.9	1.7	-0.0	1.5	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	2.7	1.6	-0.5	-0.1	1.3	-0.5	-0.0	0.5	-1.4	0.9	-0.1
Depressed Affect (Nagel 2018)	0.8	1.7	4.6	2.1	-0.5	-1.0	0.2	-1.3	0.5	1.6	1.5	1.6	1.3
Depression (Nagel 2018)	0.7	1.0	2.3	0.6	1.4	1.5	-0.8	1.5	1.0	-0.1	0.1	-0.5	-1.2
Intelligence (Savage-Jansen 2018)	2.1	6.5	17.2	-0.3	4.2	3.8	-0.2	4.0	0.9	0.2	1.0	-1.4	-3.7
Neuroticism (Nagel 2018)	0.8	2.0	4.9	2.2	-0.3	-0.8	0.9	-1.1	0.7	2.1	1.3	2.0	1.0
Schizophrenia (2018)	0.5	1.1	3.0	1.5	0.2	0.6	1.2	0.2	1.5	-0.8	-1.7	0.0	-0.7
Schizophrenia vs Biploar Disorder	0.5	0.6	1.8	-0.4	0.5	0.5	-1.4	-0.1	0.6	-1.1	-0.5	-1.1	-0.7
Worry (Nagel 2018)	1.0	2.1	5.4	2.0	-1.1	-1.4	1.1	-1.1	0.5	2.0	0.2	2.3	1.4
Alzheimer’s Disease (in mother)	2.0	2.3	6.4	-2.5	0.7	1.3	-0.5	1.4	0.3	-1.8	-1.1	-2.2	-1.6
Alzheimer’s Disease (in father)	1.6	1.7	7.7	-2.8	-0.6	-0.2	-2.3	-0.7	-0.6	-0.7	-1.3	-0.8	0.1
Alzheimer’s Disease (including proxy)	4.0	5.7	22.1	-4.7	1.5	2.0	-2.5	1.5	0.3	-2.0	-1.5	-3.1	-2.2
Crohns Disease (2017)	0.6	1.4	4.6	1.8	1.3	0.6	0.4	0.4	1.5	1.0	2.1	0.6	-0.2
Irritable Bowel Disease (IBD)	0.3	0.7	3.5	1.4	0.7	-0.1	-0.1	-0.2	0.4	0.6	1.9	0.2	0.1
Ulcerative Colitis (UC)	0.3	0.6	1.7	0.4	-0.4	-0.9	-1.0	-1.3	-0.8	-0.4	0.8	-0.7	0.5
Major Depression (MDD)	0.6	0.8	2.2	0.8	-1.1	-1.2	0.6	-1.5	0.1	0.1	0.3	0.1	1.3
Reaction Time	1.1	2.1	4.5	-2.1	-2.1	-1.5	-0.8	-1.7	-1.5	0.0	-1.9	0.3	0.8
Verbal and Numeric Reasoning (VNR)	1.7	4.2	12.5	0.2	3.5	3.0	-0.9	2.8	0.2	0.9	1.8	-0.5	-2.7
Breast Cancer	1.0	2.4	9.6	-0.6	1.8	1.4	0.0	2.4	-3.1	0.1	1.3	-0.4	-0.7
Ovarian Cancer	0.6	0.8	4.2	-0.6	-0.6	0.2	0.2	0.6	1.2	-1.1	-2.0	-0.6	-0.2
Prostate Cancer	2.7	3.9	10.0	-3.2	0.9	1.4	-2.3	0.8	0.0	-2.6	-1.4	-3.1	-1.3
Age at First Birth	0.8	1.1	5.4	-2.3	-0.3	-0.0	0.1	1.0	-0.1	-1.3	-1.2	-1.2	-0.4
Bipolar Disorder (2011)	0.2	0.2	1.1	-0.1	-0.3	0.2	1.1	-0.3	-0.4	0.1	-0.9	0.2	-0.1
Body Mass Index (BMI) (2010)	0.4	0.5	1.6	0.2	0.9	0.6	-0.3	0.9	0.8	-0.2	1.3	-0.3	-0.7
Coronary Artery Disease (CAD)	0.8	0.9	1.5	-1.2	-0.4	-1.0	-1.2	-1.2	-0.5	-0.7	1.1	-0.9	0.8
Crohns Disease (2012)	0.9	1.5	4.5	2.1	0.6	-0.1	1.2	-0.2	1.9	1.0	1.5	1.1	0.4
Mean Putamen Volume	0.2	0.2	0.5	-0.2	-0.6	-0.7	-0.1	-0.5	-0.4	-0.4	0.1	-0.1	0.7
Fasting Glucose	0.4	0.5	2.1	1.5	0.4	0.3	0.4	0.1	1.1	0.4	0.9	0.3	0.1
HbA1C	0.9	1.0	3.7	0.9	-0.1	-0.7	-0.4	-0.5	-1.0	1.2	1.9	0.8	1.1
HDL Cholesterol	1.7	2.9	6.2	-1.6	1.5	2.0	-0.3	1.5	1.4	-2.1	-1.1	-2.5	-2.0
LDL Cholesterol	1.2	1.9	3.5	1.1	-1.0	-1.6	0.0	-0.7	-1.6	1.8	1.3	1.9	1.4
Lupus	0.6	0.9	2.7	1.2	0.5	-0.4	0.7	0.4	-0.3	1.6	1.6	1.4	0.1
Neuroticism (2016)	0.1	0.2	0.8	-0.5	-0.1	-0.1	-0.4	-0.5	0.9	0.4	-0.1	0.6	-0.2
Primary Biliary Cirrhosis	0.7	1.0	3.0	-1.5	0.6	0.6	-0.1	0.0	-0.1	-1.6	-0.7	-1.7	-0.7
Rheumatoid Arthritis	1.8	2.5	4.3	-0.9	1.8	1.7	-1.9	1.9	1.2	-1.3	-0.2	-1.8	-2.1
Schizophrenia (2014)	0.3	0.7	2.7	1.6	-0.2	-0.2	1.4	-0.7	0.8	0.4	-0.7	0.5	0.2
Triglycerides	0.8	1.3	3.9	0.7	0.6	0.1	0.3	0.6	-2.0	1.7	1.4	1.6	0.1
Type 2 Diabetes (T2D) (2012)	4.2	4.9	9.6	-1.7	1.7	2.4	-1.2	2.1	2.6	-3.1	-1.6	-2.6	-2.4
Ulcerative Colitis	0.2	0.3	0.8	0.5	0.0	-0.6	-0.2	-0.9	-0.4	-0.1	0.9	-0.3	0.2
Blood Eosinophil Count	0.5	4.0	16.9	-2.5	2.0	0.7	-4.1	1.1	-0.9	1.1	3.0	-0.5	-0.6
Blood Platelet Count	0.4	4.7	7.8	-1.5	2.7	2.6	2.8	2.7	-2.8	1.3	0.6	-0.0	-2.3
Blood Red Count	1.1	10.2	31.5	-5.6	-3.2	-2.2	-2.0	-3.5	-2.7	-3.6	-2.6	-3.0	1.9
Blood White Count	3.1	23.2	47.5	-6.9	6.0	5.3	-4.4	5.6	-3.5	-0.7	2.5	-4.9	-5.1
Heel T-Score	0.3	2.7	11.8	-0.8	0.7	0.9	-3.4	1.4	-0.8	1.3	2.7	-1.2	0.2
BMI	0.4	2.2	6.9	2.3	0.1	-0.7	-0.4	-0.3	-0.7	1.8	2.6	1.7	1.4
Height	2.4	46.3	83.2	8.1	-8.0	-7.0	3.5	-7.7	5.8	6.7	-1.6	9.1	7.0
Waist Hip Ratio (WHR)	1.3	5.9	13.3	-1.5	-3.3	-3.6	-1.9	-2.8	-3.3	1.1	0.0	1.1	2.9
Systolic Blood Pressure	6.0	30.0	54.5	-3.6	6.5	7.1	-2.6	6.3	2.1	-5.8	-2.1	-7.1	-7.4
Smoking Status	2.4	5.8	9.6	2.6	-2.7	-2.7	0.8	-3.1	-1.7	2.5	0.9	3.1	2.6
Allergy or Eczema	0.3	0.8	1.6	0.5	1.3	0.8	-0.4	1.0	-1.0	1.1	1.3	0.5	-0.8
Cardiovascular Disease	1.5	4.9	14.0	-1.2	2.6	2.6	-1.9	1.6	-0.6	-2.6	-0.0	-3.7	-2.6
Hypothyroidism (self reported)	0.4	1.0	2.3	1.5	0.8	0.4	0.4	1.5	0.8	1.1	1.2	0.9	0.3
Respiratory disease	0.7	1.5	3.1	-0.7	1.5	1.8	0.4	1.6	0.3	-1.5	-0.5	-1.2	-1.5
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.5	0.7	1.3	1.4	-1.5	1.6	0.5	-0.3	-0.0	-0.6	-1.4
Lung FEV1/FVC ratio	1.5	7.4	20.4	-4.0	2.0	2.4	-3.3	1.7	-4.5	-0.6	-1.0	-2.4	-2.7
Lung FVC	1.6	8.0	25.1	-0.5	-4.4	-3.7	1.5	-5.0	-1.0	1.2	-0.7	2.0	3.5
Neuroticism	0.7	1.7	4.9	2.2	-0.0	-0.5	0.1	-0.5	0.9	2.1	1.4	1.9	0.9
Chronotype (morning person)	0.3	0.6	1.4	-0.6	0.4	0.5	-1.0	0.5	-0.5	-1.2	-0.6	-1.1	-1.1
Hair Pigment	0.0	0.5	4.6	-0.2	0.5	0.6	2.1	0.3	0.0	0.1	-0.2	0.2	0.2
Tanning	0.1	1.6	4.6	1.5	-1.4	-1.2	0.8	-1.0	-2.1	0.8	0.1	1.4	1.4
Hand grip strength (left)	0.9	2.5	11.1	2.0	-0.1	0.5	1.7	-0.0	3.3	-1.8	-1.7	-0.4	-0.5
Number of treatments/medications taken	0.8	1.5	7.8	0.8	0.4	-0.8	0.4	-0.5	-2.1	0.7	2.8	0.1	0.4
Average weekly spirits intake	1.4	1.7	4.9	2.2	-0.2	-0.4	2.1	0.0	-0.1	1.7	0.8	1.8	0.9
Sensitivity / hurt feelings	1.0	1.7	6.2	1.5	1.1	0.4	1.1	-0.3	2.5	1.4	1.7	1.0	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.7	0.9	-0.3	-0.1	0.0	0.3	-0.1	0.2	-0.3	0.4	0.3
Hearing difficulty/problems: Yes	1.2	1.8	6.5	2.6	1.2	1.1	0.4	1.1	0.5	1.9	0.9	1.5	-0.4
Relative age of first facial hair	0.3	0.6	3.5	-0.5	-0.5	-0.3	-1.9	-0.4	1.0	-0.4	-0.7	-0.2	0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.8	1.1	-0.0	-0.1	1.1	0.0	-1.4	1.7	1.4	1.3	0.7
Ever used hormone-replacement therapy (HRT)	2.2	2.9	5.9	2.3	-0.6	-1.4	1.1	-1.2	-0.8	2.3	2.4	2.2	1.3
Ever had hysterectomy (womb removed)	1.1	1.3	4.1	0.9	-0.6	-0.5	-2.0	-0.6	1.1	1.5	0.7	1.5	0.6
Systolic blood pressure, automated reading	4.2	12.1	23.7	-2.2	4.1	4.4	-1.3	4.3	1.3	-3.8	-1.2	-4.3	-4.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	3.1	0.9	0.4	-0.2	-1.1	-0.3	-0.6	-0.0	1.8	-0.6	0.5
Angina	2.9	3.8	10.0	-0.1	1.8	2.2	3.2	2.6	0.4	-1.7	-1.5	-1.4	-2.2
Medication for hormone replacement therapy	0.8	0.9	2.4	1.5	-0.6	-0.7	0.2	-1.1	-1.3	1.0	0.6	0.8	0.6
Vitamin and mineral supplements	1.5	2.0	5.6	0.9	1.2	0.5	-2.4	1.4	-1.0	1.8	2.2	0.8	0.2
Supplements: Zinc	1.1	1.2	4.0	0.8	-0.8	-0.4	2.0	-1.2	1.7	-0.4	-1.3	0.6	0.3
Medication: Co-codamol	2.3	2.6	5.5	-1.5	2.1	2.3	1.0	1.9	0.2	-1.2	-1.2	-1.6	-2.0
Medication: Metformin	0.2	0.3	1.2	0.3	-0.8	-0.6	-0.0	-1.1	-0.4	-0.4	-0.7	-0.1	0.3
Diabetes (father)	1.3	1.6	2.8	1.6	-1.3	-1.7	-0.9	-1.6	1.0	0.5	0.6	1.0	1.7
Diabetes (mother)	0.4	0.5	4.0	0.7	-0.2	-0.1	2.0	0.6	0.2	-0.2	-0.2	0.3	0.1
Severe depression (siblings)	0.3	0.4	1.2	0.5	0.5	0.2	0.4	0.7	0.9	0.7	1.1	0.4	0.2
Pack years adult smoking proportion	2.9	4.5	9.8	-0.2	-2.7	-3.0	-0.2	-2.4	-3.1	1.0	0.7	1.3	3.0
Impedance of leg (right)	0.6	3.0	16.5	-4.1	-0.7	-0.3	-1.1	-1.1	-2.2	-0.6	-1.8	-1.3	-0.6
Leg fat-free mass (left)	1.7	8.9	21.1	4.6	-2.8	-3.1	0.8	-2.7	1.8	3.0	1.3	3.9	3.6
Trunk fat percentage	1.0	3.9	6.5	1.8	-1.8	-2.5	-1.3	-2.3	0.1	1.9	2.1	2.0	2.5
Hand grip strength (right)	0.7	1.9	14.0	1.6	-0.2	0.1	0.5	-0.4	3.7	-0.7	-1.1	0.4	-0.0
Townsend deprivation index at recruitment	2.0	2.9	5.9	1.2	-1.6	-2.0	-0.4	-1.7	-2.4	1.3	1.5	1.4	2.4
Current tobacco smoking	1.8	2.9	7.7	2.8	-1.4	-1.6	1.9	-0.8	-1.1	1.6	0.6	2.4	1.8
Average weekly fortified wine intake	3.1	3.6	8.1	2.0	-1.7	-2.1	-0.2	-1.7	-0.8	2.8	1.4	2.7	1.9
Maternal smoking around birth	1.5	2.2	6.3	2.5	-1.3	-1.4	-0.6	-1.6	2.1	0.4	0.5	1.3	1.7
Fed-up feelings	1.0	1.9	4.8	1.7	-1.3	-1.5	-1.1	-2.2	-0.6	0.8	1.2	1.0	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.5	0.1	0.6	-0.3	0.5	0.3	-0.0	-0.8	-0.2	-0.6
Relative age voice broke	1.7	2.6	9.0	-1.6	-1.0	0.2	-2.1	-0.2	1.4	-2.3	-3.0	-1.4	-0.1
Taking other prescription medications	0.3	0.4	2.5	0.3	0.2	-0.3	1.0	-0.4	0.1	0.1	1.6	-0.1	0.3
Age when periods started (menarche)	0.2	0.6	2.9	-1.7	0.2	0.6	0.2	-0.0	-0.9	-0.0	-1.0	-0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	5.5	2.2	-1.2	-1.6	-0.7	-0.5	0.0	2.3	1.9	2.3	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	6.1	2.1	0.2	-0.2	-1.2	0.4	-0.4	1.9	2.5	0.7	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.9	0.6	-0.4	-0.0	1.1	-0.4	0.2	-0.4	-1.7	0.8	-0.2
Qualifications: CSEs or equivalent	1.0	1.4	3.8	-0.8	-1.5	-1.4	-1.4	-1.4	-2.0	0.1	0.0	0.1	1.0
Serious illness, injury or assault to yourself	0.7	0.9	4.5	0.3	0.6	0.4	0.4	1.1	-2.1	1.0	0.9	0.4	-0.2
High blood pressure	1.9	5.2	11.4	-0.8	3.4	2.9	-0.8	2.7	-0.7	-2.1	0.8	-3.1	-2.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	4.1	0.0	1.1	0.9	-2.0	0.6	0.0	0.7	0.5	0.1	-0.9
Multivitamins +/- minerals	3.6	4.5	9.0	-2.1	1.0	1.7	1.5	1.0	2.2	-3.0	-2.9	-2.4	-2.5
Stomach or abdominal pain in last month	1.5	1.9	5.4	1.1	-1.4	-1.7	0.2	-1.7	-2.3	1.3	0.3	1.3	1.1
Supplements: Glucosamine	3.0	4.0	6.4	1.2	-1.6	-2.5	1.7	-2.5	-0.3	2.5	1.8	2.4	2.0
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.1	0.7	-1.0	-1.4	0.9	-1.3	-0.8	1.4	0.7	1.1	1.0
Medication: Atenolol	2.4	3.0	6.4	-0.9	2.4	2.2	-0.1	2.0	1.1	-1.5	-0.3	-2.1	-2.5
Medication: Levothyroxine sodium	0.4	0.7	1.8	1.1	1.0	0.4	0.8	1.3	0.4	0.6	1.3	0.4	-0.1
Sitting height	1.3	9.1	33.1	5.8	0.6	-0.1	-0.3	0.0	5.7	3.2	2.1	3.3	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	3.2	0.4	0.2	-0.5	-1.0	0.1	0.9	1.0	1.8	0.4	0.5
High blood pressure (mother)	0.5	0.7	2.2	1.1	0.3	-0.2	0.1	-0.5	-0.6	1.4	1.5	1.0	0.3
Body mass index (BMI)	0.6	2.7	7.4	2.2	-0.5	-1.5	-0.2	-0.9	-1.0	1.9	2.7	1.8	1.8
Impedance of leg (left)	0.5	2.2	12.2	-3.5	-0.6	-0.3	-1.2	-1.2	-1.2	-0.8	-1.5	-1.3	-0.6
Leg predicted mass (left)	1.7	9.0	21.5	4.6	-2.7	-3.1	0.8	-2.7	1.9	3.0	1.4	3.9	3.6
Trunk fat mass	1.4	6.1	9.6	2.8	-2.3	-3.0	-0.9	-2.8	0.6	2.6	2.2	2.9	3.1
Waist circumference	1.2	4.5	7.5	2.3	-1.7	-2.6	-0.3	-2.0	-0.7	2.6	2.2	2.6	2.7
Number of incorrect matches in round	0.3	0.5	1.3	1.0	-1.0	-0.9	-0.4	-0.6	-0.5	0.4	0.2	0.6	1.1
Past tobacco smoking	1.2	2.2	4.2	-1.7	1.4	1.4	0.2	2.1	1.5	-1.9	-0.4	-2.0	-1.0
Alcohol usually taken with meals	1.3	2.1	5.7	-1.0	2.4	2.0	-0.6	2.2	0.6	-0.1	0.3	-0.8	-2.0
Nervous feelings	1.4	2.7	7.8	2.5	-0.6	-1.1	1.3	-0.7	-0.1	2.5	1.1	2.8	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.8	0.8	0.2	-0.4	0.2	-0.2	0.7	0.9	0.4	0.0
Hearing difficulty/problems with background noise	1.9	3.1	13.5	3.7	0.2	0.2	-0.1	0.1	1.2	2.7	0.7	2.8	0.2
Hair/balding pattern: Pattern 2	0.5	0.6	2.8	-0.5	1.0	0.8	-1.7	-0.3	-0.2	0.1	0.3	-0.4	-1.0
Had menopause	0.9	1.2	2.7	1.4	-0.4	-0.8	1.4	-0.5	-1.0	1.4	0.9	1.6	0.5
Had other major operations	0.2	0.3	1.1	1.1	0.4	0.1	-0.4	0.9	-0.0	0.5	0.6	0.2	-0.2
Forced vital capacity (FVC)	1.4	5.3	14.7	0.4	-3.6	-3.0	0.5	-3.8	0.7	1.3	-1.6	2.2	2.6
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	9.3	2.0	0.7	0.1	-0.5	0.7	-0.7	2.6	3.1	1.3	0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	1.2	-0.9	-1.1	1.6	-0.6	-0.6	0.5	0.2	1.0	1.2
Qualifications: None of the above	1.0	2.1	5.3	1.6	-0.3	-1.5	1.6	-1.1	-0.6	1.3	2.3	1.7	1.6
Financial difficulties in last 2 years	0.8	1.0	4.9	2.2	0.6	0.2	-0.8	-0.4	-0.7	1.0	1.5	0.6	0.3
Mouth/teeth dental problems	1.2	1.8	3.0	-1.4	1.4	1.6	-1.3	1.5	0.3	-1.4	-0.4	-1.7	-1.6
Heart attack	0.5	0.6	2.0	-1.4	0.5	0.8	-0.6	1.1	-0.8	0.0	-0.6	-0.3	-0.6
Allergy	0.4	1.0	2.7	0.3	-1.7	-1.5	0.3	-1.3	-1.0	0.1	-0.1	0.3	1.4
Pain all over the body in last month	0.9	1.0	1.9	0.9	-0.7	-1.1	0.6	-0.8	0.8	1.0	1.4	0.9	1.4
Diabetes (self-reported)	0.6	0.9	2.8	0.4	1.2	1.2	-1.4	1.7	0.1	-0.3	0.6	-0.7	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	0.3	1.3	1.1	-1.1	0.8	1.0	0.0	0.7	-0.4	-0.8
Medication: Ramipril	2.3	3.0	5.6	-1.4	1.8	1.9	-1.2	1.4	-1.9	-1.8	-0.9	-2.4	-2.1
Medication: Simvastatin	1.4	2.1	5.0	-0.5	1.4	1.6	-0.1	1.7	-0.3	-2.1	-1.0	-2.2	-1.6
Fluid intelligence score	2.2	4.6	13.8	-0.1	3.7	2.9	-1.4	2.9	1.4	0.8	2.1	-0.6	-2.6
Illnesses of siblings	0.4	0.6	1.6	0.4	-1.3	-0.9	1.1	-0.7	-0.3	-0.2	-0.9	0.3	0.6
Neuroticism score	0.5	1.1	3.1	1.7	-0.4	-0.4	0.5	-0.7	0.7	1.6	0.5	1.8	0.8
Weight	1.7	8.5	14.1	3.7	-2.6	-3.4	0.1	-3.0	1.0	3.3	2.0	3.8	3.6
Impedance of arm (right)	0.4	1.9	8.0	-2.8	-1.3	-0.6	0.0	-1.3	0.8	-1.2	-1.8	-1.4	0.2
Arm fat percentage (right)	0.5	1.9	4.1	1.1	-1.2	-1.9	-0.5	-1.2	-0.8	1.1	1.9	1.0	2.0
Trunk fat-free mass	1.2	6.7	13.7	3.7	-2.7	-2.8	1.0	-2.6	1.9	2.4	0.2	3.3	3.0
Hip circumference	1.0	4.4	16.4	4.0	-0.7	-1.2	0.7	-0.8	2.4	2.2	1.8	2.8	1.8
Time employed in main current job	0.7	0.8	2.1	0.1	0.7	0.9	1.1	1.3	-1.4	-0.4	-0.2	-0.6	-0.9
Alcohol intake versus 10 years previously	0.6	0.9	1.5	0.5	1.2	1.2	1.1	0.7	0.3	-1.1	0.2	-1.1	-1.1
Father’s age at death	0.6	0.8	2.4	-1.1	0.6	0.9	-1.6	1.2	0.8	0.1	-0.7	-0.2	-1.0
Worrier / anxious feelings	1.0	1.9	4.9	1.3	-1.1	-0.9	1.9	-1.0	1.1	1.6	-0.8	2.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	5.6	1.8	-0.9	-1.3	0.7	-0.8	-1.3	2.4	1.6	1.9	1.3
Falls in the last year	0.4	0.5	2.2	0.3	0.3	0.3	1.5	-0.2	-0.1	-0.6	-1.2	-0.5	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.6	0.5	0.6	0.2	0.5	0.6	-0.1	-0.3	0.2	-0.6
Number of live births	0.6	0.9	2.4	1.6	-0.4	-0.9	0.4	-0.9	-0.3	1.0	0.6	1.4	0.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	11.3	-0.8	-3.0	-2.3	0.0	-3.4	-0.8	1.2	-1.6	1.4	1.9
Pulse rate	0.5	0.9	3.6	-0.0	0.4	-0.3	-0.5	-0.3	-1.9	1.2	1.9	0.1	0.1
Happiness	0.2	0.2	0.8	0.4	-0.2	-0.0	0.9	-0.1	-0.5	0.2	-0.4	0.6	-0.1
Noisy workplace	1.7	2.1	4.1	1.0	-1.3	-2.0	-0.2	-1.6	-1.4	1.9	1.6	1.5	1.4
Qualifications: A levels/AS levels or equivalent	1.4	3.1	6.0	-1.6	2.0	2.4	-0.3	2.1	0.3	-1.7	-1.2	-2.5	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.9	0.7	-1.0	-0.4	-1.1	-1.0	-0.6	-0.5	-1.7	-0.1	0.3
Mouth/teeth dental problems: Dentures	2.5	4.3	9.4	1.2	-3.1	-2.7	1.6	-2.8	1.4	0.2	-1.7	1.8	2.5
Asthma	0.9	1.7	5.2	-0.1	2.1	2.0	0.3	2.3	0.9	-0.3	0.3	-0.4	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	5.6	1.0	0.0	-1.1	-1.2	-1.2	-1.4	1.2	2.4	0.9	1.3
Medication: Cholesterol lowering	1.0	1.6	3.5	1.8	1.7	1.6	0.1	1.9	-0.0	-0.9	0.1	-0.8	-1.6
Depression (self-reported)	1.4	1.7	3.1	1.0	1.6	1.6	1.7	0.8	1.1	-1.1	0.3	-1.4	-1.6
Medication: Lansoprazole	0.4	0.4	1.8	-0.8	-0.1	0.1	0.2	0.3	-0.1	-1.4	-0.8	-0.9	-0.3
Prospective memory result	0.2	0.3	0.9	-0.6	-0.1	0.4	-0.9	0.6	-0.1	-0.5	-0.2	-0.7	-0.1
Lung cancer (father)	0.2	0.3	0.9	0.1	-0.3	-0.7	0.1	0.0	0.5	0.6	1.0	0.7	0.5
Illnesses of mother	0.2	0.3	1.1	0.2	-0.3	0.1	-0.2	0.4	1.1	-0.5	-1.0	0.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	11.1	-0.6	-3.0	-2.5	0.2	-3.3	-1.4	1.7	-1.5	1.7	1.9
Pulse wave Arterial Stiffness index	0.8	1.0	3.2	-0.6	0.5	0.3	-1.8	1.1	1.1	1.0	1.6	-0.0	-0.1
Impedance of arm (left)	0.3	1.5	4.7	-2.2	-1.4	-0.7	-0.6	-1.6	1.1	-0.9	-1.2	-1.0	0.5
Arm fat mass (right)	0.8	3.4	6.2	2.3	-1.5	-2.3	-0.3	-1.8	0.1	1.9	2.0	2.0	2.5
Trunk predicted mass	1.2	6.7	13.5	3.7	-2.7	-2.9	1.0	-2.6	1.8	2.4	0.2	3.3	3.1
Standing height	1.5	15.4	25.2	3.6	-4.9	-4.4	1.0	-5.0	4.5	3.2	-1.4	4.5	4.3
Length of working week for main job	0.2	0.3	0.8	0.7	0.6	0.4	-0.4	0.3	-0.3	0.9	0.5	0.4	-0.4
Exposure to tobacco smoke at home	0.5	0.5	1.9	0.6	-1.0	-0.8	0.2	-1.4	-0.9	0.4	-0.5	0.5	0.4
Breastfed as a baby	0.8	1.0	7.5	-0.3	-0.2	0.2	-1.2	0.0	-2.7	0.9	-0.1	0.0	-0.0
Tense / ‘highly strung’	1.1	1.9	4.5	-0.2	-2.1	-1.5	0.8	-2.1	-1.1	-0.1	-1.7	1.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.1	-0.4	2.0	1.9	0.8	1.0	0.8	-1.4	0.3	-2.0	-1.9
Hair/balding pattern: Pattern 4	0.6	1.5	7.9	0.2	1.2	1.3	2.8	1.4	-0.7	-0.3	0.0	-0.7	-1.1
Birth weight of first child	1.5	2.8	6.0	1.6	-2.4	-2.4	-0.9	-2.2	0.7	0.6	0.3	1.2	2.4
Peak expiratory flow (PEF)	1.0	2.4	5.8	1.2	-1.3	-1.1	2.0	-1.0	-1.6	2.4	0.0	2.4	0.8
Pulse wave reflection index	0.6	0.7	3.3	-0.8	-0.2	0.3	-1.8	0.2	1.5	-0.2	-0.6	-0.3	0.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.9	0.1	-1.0	-1.3	0.1	-1.7	-0.1	0.5	0.7	0.5	1.3
Loud music exposure frequency	0.4	0.5	1.7	-0.9	-0.3	-0.5	-1.3	-0.6	0.5	0.1	0.9	-0.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	-0.2	0.8	1.3	-1.2	0.6	0.1	-0.4	-0.2	-0.8	-1.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.1	0.9	0.4	-0.0	1.6	0.2	-1.8	1.3	1.7	0.6	0.4
Blood clot in the leg (DVT)	1.9	2.4	4.0	-1.1	1.8	2.0	0.6	1.8	1.6	-1.4	-0.7	-2.0	-1.9
Medication: Paracetamol	2.8	4.6	7.8	2.2	-1.1	-2.3	0.3	-1.7	-2.0	2.8	2.7	2.6	2.5
Headache pain in last month	0.5	0.9	4.2	0.8	0.9	-0.1	-1.3	0.2	-0.7	0.7	2.0	0.1	0.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.7	-0.8	-1.8	-1.9	-0.2	-1.8	0.6	1.0	-0.1	1.1	1.9
Glaucoma (self-reported)	0.3	0.4	1.3	-0.5	-0.1	0.3	-1.1	-0.1	-0.7	-0.4	-1.1	-0.5	-0.3
Gout (self-reported)	1.3	1.8	4.8	-1.3	1.7	1.6	0.5	2.2	-1.0	-0.7	0.8	-1.4	-1.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	5.4	2.3	0.9	0.5	1.5	1.4	0.5	0.8	1.1	0.9	-0.0
Medication: Amlodipine	1.6	2.3	9.3	-3.1	0.9	1.1	-0.8	0.6	-0.7	-1.5	-0.2	-2.5	-1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.2	-0.9	1.8	1.3	-1.2	1.0	1.1	-0.7	0.7	-1.1	-1.3
Birth weight	2.1	4.5	10.7	2.5	-1.0	-1.8	0.7	-1.1	0.5	3.3	2.7	3.0	2.4
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.4	1.6	-0.7	-1.5	-0.1	-0.8	1.1	1.5	1.5	1.8	1.5
High blood pressure (siblings)	0.3	0.4	1.2	-0.6	1.0	1.1	-0.2	0.5	0.7	0.4	-0.0	-0.2	-0.8
Forced vital capacity (FVC), Best measure	1.6	5.7	15.1	0.6	-3.6	-3.0	0.8	-3.9	0.4	1.5	-2.0	2.4	2.5
Body fat percentage	0.8	3.3	5.4	1.4	-1.5	-2.3	-1.4	-2.0	-0.8	1.8	2.3	1.7	2.3
Leg fat percentage (right)	0.7	2.4	7.5	0.1	-0.6	-1.6	-1.2	-1.1	-2.7	1.6	2.4	1.0	1.3
Arm fat-free mass (right)	1.5	7.5	17.9	4.2	-2.5	-2.9	0.4	-2.9	1.6	2.6	0.8	3.7	3.2
Exposure to tobacco smoke outside home	1.2	1.6	4.2	0.8	-2.0	-1.7	0.3	-1.7	-0.4	0.9	0.2	1.3	1.8
Comparative body size at age 10	0.4	1.2	4.1	0.5	-0.9	-1.1	0.2	-0.7	-1.1	0.9	1.2	1.4	2.0
Number of full brothers	0.1	0.1	0.2	-0.1	-0.0	-0.2	0.2	-0.5	0.1	-0.3	-0.2	-0.5	-0.2
Worry too long after embarrassment	1.2	2.0	6.5	2.5	0.9	0.8	0.2	0.4	2.0	1.7	1.2	1.9	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	4.1	0.0	2.0	1.9	0.9	1.6	1.3	-0.9	0.5	-1.5	-1.7
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.1	-0.2	-0.4	0.4	0.1	0.5	-0.6	0.3	0.0	0.3
Number of children fathered	0.5	0.6	1.7	0.5	1.1	0.9	-1.3	0.7	0.7	-0.1	0.3	-0.4	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.1	-0.2	-0.4	-0.1	-0.9	-0.5	0.8	-1.4	-1.1	-1.2	0.0
Age at first live birth	0.8	1.4	5.5	-1.5	0.0	0.8	0.8	0.5	1.4	-1.2	-2.3	-0.9	-0.9
Pulse wave peak to peak time	1.0	1.2	3.7	0.8	-0.8	-0.6	1.9	-1.4	-0.9	-0.7	-1.6	0.4	0.4
Health satisfaction	2.0	2.6	6.5	1.9	-0.7	-1.4	0.8	-1.6	-0.3	2.2	2.5	1.9	1.6
Shortness of breath walking on level ground	1.7	2.0	4.7	1.2	-1.0	-1.4	2.2	-1.2	-1.5	0.9	1.6	0.7	1.7
Qualifications: College or University degree	0.6	1.8	4.1	0.3	1.7	1.8	1.7	1.6	2.0	-0.5	-0.3	-0.7	-1.0
Eye problems/disorders: None of the above	1.1	1.3	3.4	-0.1	1.8	1.1	-1.2	1.7	-0.2	0.4	1.3	-0.6	-1.5
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.4	1.2	-0.9	-0.9	1.5	-0.8	-1.8	2.0	0.7	2.3	1.0
Emphysema/chronic bronchitis	1.2	1.3	2.8	-1.3	0.9	1.0	1.7	-0.1	-0.4	-1.4	-0.4	-1.6	-1.4
Medication for pain relief, constipation, heartburn	1.0	1.7	4.4	-1.5	0.0	1.0	-0.3	1.1	2.1	-1.5	-1.8	-1.4	-0.9
Neck or shoulder pain in last month	1.7	2.3	6.2	2.5	0.3	-1.0	-0.6	-0.6	0.3	2.4	2.3	2.0	0.9
Medication: Blood pressure	1.5	2.7	5.7	0.6	2.4	2.4	0.5	2.2	-0.6	-1.2	0.5	-1.6	-2.4
Angina (self-reported)	3.1	4.1	10.1	-0.4	1.9	2.4	3.2	2.6	0.2	-1.8	-1.6	-1.7	-2.4
Migraine (self-reported)	0.6	0.7	2.8	1.7	0.9	1.0	0.0	0.7	-0.8	0.7	0.4	0.3	-0.8
Medication: Ibuprofen	3.1	3.7	11.3	1.9	-0.1	-1.6	-1.7	-1.4	-1.6	2.3	3.4	1.8	1.8
Medication: Allopurinol	1.6	2.1	4.4	-1.3	1.8	1.6	-0.1	1.8	0.5	-1.7	0.6	-2.1	-1.4
Medication: Omeprazole	0.9	1.1	2.1	-0.3	1.5	1.1	1.0	1.2	0.2	-1.1	0.1	-1.4	-1.4
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.8	0.0	-0.1	0.7	0.3	1.1	-0.5	-0.6	0.2	-0.1
Mean time to correctly identify matches	1.1	2.0	6.3	-2.5	-1.7	-1.0	-0.7	-1.4	-1.7	-0.2	-2.1	-0.0	0.3
Heart disease (mother)	0.5	0.6	1.2	0.5	0.9	1.1	0.0	1.0	0.9	-0.4	-0.5	-0.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.2	1.5	0.7	0.6	-0.3	1.4	0.4	0.1	0.2	0.3	-0.5
Whole body fat mass	1.3	5.6	9.0	2.8	-2.0	-2.9	-0.7	-2.5	-0.0	2.6	2.4	2.8	3.0
Leg fat mass (right)	1.3	4.9	7.9	2.3	-1.6	-2.6	-0.9	-2.1	-1.1	2.8	2.7	2.6	2.6
Arm predicted mass (right)	1.5	7.5	17.9	4.2	-2.4	-2.8	0.2	-2.7	1.3	2.9	1.2	3.8	3.2
Pulse rate, automated reading	1.0	3.2	7.5	1.1	-1.5	-2.2	-0.5	-2.3	-2.7	1.5	1.9	1.3	1.8
Alcohol intake frequency.	0.3	0.8	3.4	0.3	-0.2	-0.8	0.8	-0.1	-1.9	0.4	1.4	0.3	0.9
Comparative height size at age 10	1.5	8.1	15.8	1.6	-3.9	-3.7	1.0	-4.0	2.5	1.3	-1.4	2.7	4.0
Number of full sisters	1.4	1.7	4.2	2.0	-0.4	-0.8	1.6	-0.3	0.1	1.7	1.3	2.0	1.0
Suffer from ‘nerves’	0.1	0.2	0.9	-0.1	0.3	0.2	1.0	0.2	-0.5	-0.2	-0.6	-0.2	-0.4
Overall health rating	2.8	6.0	9.0	1.8	-1.8	-2.7	1.7	-2.0	-2.7	3.0	2.8	2.9	2.7
Chest pain or discomfort	0.4	0.6	3.6	0.9	0.4	-0.0	1.9	-0.1	-0.7	0.6	0.3	0.8	-0.2
Had major operations	1.8	2.1	6.0	2.2	2.4	1.6	0.2	1.4	0.9	0.1	1.5	-0.2	-1.5
Age at last live birth	0.8	1.1	3.7	-1.8	0.3	0.8	-0.2	0.5	0.3	-0.9	-1.9	-1.0	-1.0
Family relationship satisfaction	1.6	1.9	4.4	0.1	-2.1	-1.7	1.0	-1.9	-0.8	0.8	-0.4	1.4	1.9
Leg pain on walking	6.3	7.9	14.5	2.2	-1.9	-3.0	-0.1	-2.9	-2.7	3.8	3.2	3.5	3.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	2.0	-0.1	-0.0	0.1	-0.7	0.2	-1.4	-0.1	-0.4	-0.1	-0.5
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.6	1.6	-0.8	-1.3	0.8	-1.6	-0.4	1.9	1.7	1.5	1.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.7	-1.0	0.1	-0.3	-0.2	0.2	1.3	0.3	0.8	0.1	0.2
Medication: Aspirin	0.8	1.0	1.6	-1.3	0.9	1.1	0.0	0.7	-0.7	-1.1	-1.0	-1.3	-1.2
Supplements: Vitamin C	5.4	6.3	15.8	1.0	-3.7	-3.5	1.9	-4.0	-0.2	1.0	-0.0	2.0	3.4
Knee pain experienced in last month	4.5	7.0	11.4	1.4	-2.1	-3.4	0.3	-3.1	-1.4	3.3	3.0	3.0	3.3
Hypertension (Self-reported)	2.1	5.7	11.6	-1.3	3.3	3.0	-1.2	2.8	-0.3	-2.4	0.4	-3.4	-3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	-0.2	-0.7	-0.5	0.6	0.0	0.7	-0.9	-1.0	-0.5	0.1
Illnesses of father: Heart disease	0.5	0.7	2.7	1.2	0.0	-0.3	0.6	-0.3	1.7	0.6	0.7	0.9	0.6
Illnesses of siblings: Diabetes	0.7	0.8	2.5	-0.6	0.8	0.6	-0.8	0.1	1.4	-1.3	0.4	-1.6	-0.5
Smoking status: Previous	0.3	0.4	1.3	0.8	-0.4	-0.4	-0.6	-1.2	-0.0	0.9	0.6	0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	7.2	2.7	-0.1	0.0	2.3	-0.2	2.4	0.5	-0.5	1.2	-0.1
Whole body fat-free mass	1.4	7.9	18.7	4.3	-2.7	-3.0	0.9	-2.6	2.1	2.6	0.7	3.7	3.4
Leg fat-free mass (right)	1.7	9.0	23.9	4.9	-2.6	-2.9	0.8	-2.6	2.6	2.7	1.3	3.8	3.5
Arm fat percentage (left)	0.6	2.2	5.3	1.3	-1.1	-1.9	-1.0	-1.3	-0.7	1.1	2.3	1.1	2.1
Average weekly red wine intake	0.5	0.7	2.8	0.6	-0.2	0.1	0.5	-0.5	1.7	-1.1	-1.4	-0.5	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.3	0.0	-0.1	0.6	-0.1	-0.6	0.3	0.5	-0.2	0.2
Mood swings	1.4	2.5	6.4	2.5	-0.6	-0.9	0.3	-0.6	0.0	2.5	1.5	2.5	1.4
Loneliness, isolation	0.4	0.5	1.2	0.2	0.1	-0.3	1.0	-0.2	-0.8	1.0	1.1	1.0	0.6
Long-standing illness, disability or infirmity	0.8	1.2	2.2	1.3	0.0	-0.5	1.4	-0.2	-1.3	1.4	1.5	1.0	0.9
Ever had bowel cancer screening	0.9	1.1	2.7	0.1	-1.6	-1.6	-0.1	-1.1	-1.0	0.9	0.4	1.0	1.2
Diabetes diagnosed by doctor	0.3	0.5	1.0	0.2	0.9	0.8	-0.8	1.0	-0.4	-0.2	0.2	-0.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.2	-1.2	-0.2	-0.1	-0.1	-0.4	-1.5	-0.1	-0.1	-0.1	-0.2
Friendships satisfaction	0.9	1.1	2.9	1.3	-0.2	-0.9	-0.2	-0.6	-0.3	1.7	1.3	1.7	0.9
Qualifications: nursing, teaching	0.1	0.2	1.3	-1.2	0.1	0.4	-0.3	0.1	-0.6	-0.0	-0.2	-0.5	0.2
Commuting to job workplace: Walk	0.3	0.3	1.4	0.5	-0.0	-0.3	0.3	-0.3	0.2	1.0	0.6	1.2	0.4
Eye problems/disorders: Cataract	0.4	0.4	1.4	0.9	-0.3	-0.1	1.2	0.1	-0.7	0.5	0.3	0.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.0	1.1	1.7	1.1	-0.4	0.9	-0.7	0.7	1.7	-0.0	-0.9
Medication for cholesterol	1.0	1.6	6.6	1.5	-0.9	-0.9	0.0	-0.7	2.6	0.6	-0.3	1.9	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	5.1	2.3	0.2	-0.0	0.3	-0.1	1.2	1.1	0.7	1.1	0.3
Back pain experienced in last month	2.1	3.0	5.6	2.1	-1.4	-2.1	1.4	-1.7	-0.8	2.0	1.1	2.4	1.8
Mineral and other dietary supplements	1.2	1.6	10.6	0.1	1.1	0.8	-3.3	1.4	-0.1	0.3	1.1	-0.4	-0.1
Breast cancer (self-reported)	0.9	1.0	2.9	1.1	-0.8	-1.0	-0.7	-0.4	0.4	1.7	0.5	1.6	0.9
Asthma (self-reported)	1.0	2.0	5.5	-0.2	2.2	2.1	0.1	2.4	1.0	-0.6	0.3	-0.7	-1.7
Osteoporosis (self-reported)	0.8	1.0	6.8	0.9	-0.4	-0.4	2.6	-0.6	-0.4	0.2	0.7	0.2	0.9
Osteoarthritis (self-reported)	1.7	2.2	5.9	0.0	-0.8	-1.6	1.0	-1.5	-0.7	2.4	1.1	2.2	1.8
Medication: Aspirin	0.7	0.9	1.5	-1.0	1.1	1.1	0.2	0.7	-1.0	-1.0	-0.6	-1.2	-1.2
Medication: Gliclazide	1.1	1.2	5.0	0.4	0.6	0.5	-0.7	0.9	2.2	-1.4	-0.4	-1.3	-1.0
Illnesses of father: None of the above (group 1)	0.6	0.7	2.8	-1.5	-0.2	0.3	-0.4	-0.0	-1.7	-0.5	-1.1	-0.6	-0.6
Smoking status: Current	1.5	2.4	4.4	2.1	-1.6	-1.6	1.7	-1.1	-1.6	1.3	0.2	2.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.5	-1.2	-0.8	-0.8	-0.2	-1.2	-1.9	1.2	0.2	0.8	0.5
Whole body water mass	1.4	7.9	18.8	4.3	-2.7	-2.9	0.8	-2.7	2.0	2.7	0.7	3.7	3.3
Leg predicted mass (right)	1.7	8.9	24.0	4.9	-2.6	-2.9	0.8	-2.5	2.6	2.7	1.3	3.8	3.5
Arm fat mass (left)	1.1	4.5	8.1	2.7	-1.7	-2.6	-0.4	-2.0	0.3	2.3	2.2	2.5	2.8
Number of self-reported non-cancer illnesses	0.6	1.1	2.5	-0.2	1.3	1.0	0.9	1.6	-1.5	-0.6	0.6	-1.0	-1.0
Average weekly champagne plus white wine intake	0.8	1.1	2.2	-1.3	0.5	0.6	0.3	1.2	1.2	-1.5	-1.4	-1.1	-0.8
Miserableness	0.9	1.6	4.0	2.0	0.2	-0.3	0.8	-0.3	-0.1	2.0	1.7	1.9	0.4
Guilty feelings	0.2	0.3	0.6	-0.1	-0.8	-0.4	-0.0	-0.6	0.7	0.4	-0.5	0.6	0.6
Wears glasses or contact lenses	1.2	1.3	2.9	-0.5	1.7	1.4	-1.2	1.7	1.0	-0.3	0.7	-0.8	-1.4
Ever taken oral contraceptive pill	0.8	0.9	2.7	0.5	-1.4	-0.9	0.4	-1.7	-0.7	-0.7	-1.2	0.3	0.8
Hearing aid user	1.9	2.2	6.5	2.6	0.1	-0.5	-1.2	0.5	-0.2	2.4	1.7	2.1	0.8
Mother’s age at death	1.0	1.2	6.3	-0.6	-0.3	0.5	-0.5	0.3	-1.7	-0.7	-2.5	-0.4	-1.2
Financial situation satisfaction	1.1	1.4	3.8	1.6	-0.8	-1.0	0.6	-0.8	-0.9	1.5	0.8	2.0	1.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.3	0.2	0.8	-0.4	0.7	0.8	0.3	-0.5	-0.3	-0.5
Commuting to job workplace: Public transport	0.2	0.3	1.1	-1.1	0.1	0.4	0.0	0.8	0.3	-0.5	-0.6	-0.4	-0.4
Eye problems/disorders: Glaucoma	0.4	0.4	2.7	-0.1	-0.0	0.4	-1.6	-0.4	-0.3	-0.5	-0.8	-0.5	-0.5
Medication: Blood pressure	2.3	4.3	7.6	-2.1	2.5	2.4	-2.0	2.8	-0.8	-1.3	-0.1	-2.6	-2.5
Pain type(s) experienced in last month: Hip pain	4.7	5.9	17.4	3.3	-0.8	-1.6	0.8	-1.1	0.1	4.2	3.0	3.6	1.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.5	-0.5	-1.1	-0.9	2.4	-1.4	0.9	-0.7	-1.3	0.1	0.0
High cholesterol (Self-reported)	1.0	1.8	5.4	-0.2	1.0	1.1	0.0	1.1	1.3	-2.3	-0.8	-2.3	-1.1
Medication: Bendroflumethiazide	0.6	0.9	2.0	-0.7	1.2	1.1	0.2	1.1	-0.3	-0.8	0.0	-1.3	-1.4
Medication: Paracetamol	3.4	5.3	12.3	2.5	-0.5	-1.9	-0.3	-1.4	-2.3	3.3	3.5	2.9	2.0
Medication: Lisinopril	0.8	1.0	3.6	0.0	1.4	1.1	-0.7	1.9	0.5	-0.5	0.4	-1.1	-1.0
Medication: Atorvastatin	0.1	0.1	0.4	0.6	-0.1	-0.3	0.5	-0.4	-0.3	-0.1	0.5	-0.3	0.2
Illnesses of father: High blood pressure	1.2	1.5	4.9	2.2	1.5	0.9	0.5	1.2	0.4	0.9	1.9	0.3	-0.4
Alcohol drinker status: Never	0.6	0.7	2.0	-0.6	-1.0	-1.1	-0.2	-0.4	-0.9	0.6	0.4	0.9	1.4
Ever smoked	1.3	2.3	5.2	2.3	-1.2	-1.2	-0.1	-1.4	-2.1	2.0	0.5	2.1	0.8
Basal metabolic rate	1.5	8.4	17.9	4.2	-2.8	-3.2	0.6	-2.9	1.8	2.9	1.0	3.8	3.5
Leg fat percentage (left)	0.7	2.4	6.2	0.6	-0.8	-1.9	-1.1	-1.4	-2.1	1.5	2.5	1.1	1.5
Arm fat-free mass (left)	1.4	7.2	16.1	4.0	-2.4	-2.9	0.3	-2.5	1.1	3.0	1.2	3.7	3.2
Number of operations (self-reported)	1.3	1.9	4.8	2.1	1.7	1.0	-0.6	1.8	-0.0	1.0	2.2	0.1	-1.0
Average weekly beer plus cider intake	0.3	0.5	2.2	0.3	-0.7	-0.1	0.0	-0.4	0.6	-1.1	-1.5	-0.3	0.3
Irritability	0.4	0.7	2.7	-0.8	-0.5	-0.1	-1.6	-0.7	0.8	-0.7	-1.0	-0.8	0.2
Risk taking	0.8	1.2	2.9	0.1	0.8	1.3	0.1	0.8	0.9	-1.7	-1.7	-1.2	-1.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	6.2	0.7	0.8	0.7	-0.2	1.0	2.5	-0.2	0.2	-0.3	-0.9
Fractured/broken bones in last 5 years	0.8	1.1	3.8	-0.8	0.4	1.0	0.4	0.4	-0.3	-1.9	-1.6	-1.3	-0.8
Age started oral contraceptive pill	0.6	0.7	3.6	-0.8	-0.6	-0.4	-1.2	-0.2	1.9	-0.5	-0.4	-0.1	0.4
Diastolic blood pressure, automated reading	0.7	2.1	4.7	-2.0	1.0	1.0	-1.2	0.6	-2.2	-1.3	-0.1	-1.9	-1.6
Ever depressed for a whole week	1.4	1.7	3.7	1.1	-1.4	-1.5	1.5	-1.9	-0.0	0.9	0.4	1.4	1.7
Unable to work because of sickness or disability	0.3	0.4	1.5	1.2	-0.5	-0.4	0.6	-0.3	0.6	-0.9	-0.7	-0.1	0.5
Commuting to job workplace: Cycle	0.2	0.3	0.9	0.3	-0.2	-0.5	-0.5	-0.6	-1.0	0.6	0.3	0.4	0.2
Myopia	0.3	0.4	2.2	-0.6	-0.4	0.2	0.3	0.1	-1.5	-0.5	-0.7	-0.3	-0.2
Vascular/heart problems diagnosed by doctor	2.2	6.1	11.6	1.3	-3.4	-3.2	0.0	-3.1	0.8	2.4	0.0	3.3	3.2
Cholesterol lowering medication	0.6	0.9	2.9	-1.7	-0.4	0.1	0.5	0.2	0.9	-1.2	-0.8	-1.7	-0.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.4	-0.2	1.5	1.2	1.4	1.3	0.7	-1.4	-0.0	-1.4	-1.5
Pain experienced in last month	4.7	7.8	17.2	-3.2	1.3	2.9	0.8	2.3	1.0	-3.9	-4.2	-3.2	-2.8
Supplements: Calcium	1.3	1.4	3.3	-1.8	0.4	0.6	1.6	0.9	-1.0	-1.4	-1.4	-1.1	-0.8
Basal cell carcinoma (self-reported)	1.9	2.3	5.1	1.7	-1.3	-1.3	0.0	-0.9	1.9	1.9	0.0	2.2	1.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	-1.4	0.6	0.8	-0.6	1.1	-1.1	-0.0	-0.5	-0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	4.0	-1.1	1.8	2.0	0.4	1.8	1.8	-1.6	-0.7	-2.0	-1.9
Heart disease (siblings)	0.6	0.8	3.9	0.2	0.9	0.3	-2.0	1.2	-0.4	0.1	1.0	-0.4	-0.5
Alcohol drinker status: Previous	1.4	1.6	3.9	-0.7	-1.8	-1.8	-0.4	-2.0	-1.5	0.3	-0.4	0.6	1.4
Pack years of smoking	2.6	3.7	10.9	-0.5	-2.3	-2.7	-0.4	-2.2	-3.3	0.7	0.7	0.8	2.7
Impedance of whole body	0.3	1.5	6.9	-2.6	-1.1	-0.6	-0.8	-1.4	0.1	-0.9	-1.5	-1.0	0.0
Leg fat mass (left)	1.3	5.0	7.3	2.5	-1.7	-2.7	-0.7	-2.2	-0.6	2.6	2.6	2.7	2.7
Arm predicted mass (left)	1.5	7.4	15.7	4.0	-2.5	-3.0	0.7	-2.6	1.0	3.0	1.1	3.8	3.3