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chr15:39,879,981-43,724,646

Best TWAS P=1.98e-41 · Best GWAS P=1.29e-43 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	METSIM	Adipose	EHD4	0.10	0.05	lasso	2	0.03	1.0e-05	-13.62	-13.5	2.0e-41	0.95	0.00	1.00	TRUE
10	GTEx	Nerve Tibial	EHD4	0.20	0.04	lasso	7	0.08	2.4e-06	3.02	-9.2	3.2e-20	0.21	0.92	0.04	TRUE
4	GTEx	Adrenal Gland	LTK	0.21	0.05	enet	21	0.06	3.9e-03	-3.10	7.0	2.7e-12	-0.27	0.16	0.21	TRUE
11	GTEx	Thyroid	RTF1	0.28	0.27	lasso	3	0.26	8.4e-20	6.37	6.4	1.7e-10	-0.20	1.00	0.00	TRUE
14	METSIM	Adipose	PLCB2	0.14	0.09	bslmm	401	0.09	6.2e-13	-5.14	-5.6	2.5e-08	-0.01	0.00	1.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CDAN1	0.04	0.02	blup	278	0.02	7.8e-04	-4.42	-5.4	7.0e-08	0.12	0.03	0.90	TRUE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	EHD4	0.17	0.09	blup	101	0.09	6.8e-10	5.17	-9.2	5.4e-20	0.56	0.97	0.02	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	EHD4	0.04	0.02	blup	102	0.02	1.4e-04	11.02	-8.9	8.2e-19	0.52	0.04	0.72	FALSE
2	GTEx	Adipose Subcutaneous	EHD4	0.25	0.00	enet	39	0.07	2.0e-06	-2.10	-8.3	6.6e-17	0.37	0.17	0.19	FALSE
5	GTEx	Artery Tibial	EHD4	0.14	0.03	enet	21	0.06	1.0e-05	4.24	-8.0	1.4e-15	0.17	0.80	0.01	FALSE
9	GTEx	Heart Atrial Appendage	RP11-23P13.6	0.26	-0.01	enet	13	0.01	8.6e-02	4.20	-6.3	3.6e-10	0.15	0.09	0.06	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	SPTBN5	0.37	0.21	lasso	5	0.27	5.4e-08	-2.04	-6.2	4.8e-10	0.54	0.09	0.66	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	RTF1	0.04	0.02	lasso	3	0.02	4.0e-03	6.37	6.1	8.4e-10	-0.21	0.00	0.98	FALSE
8	GTEx	Esophagus Mucosa	CHP1	0.19	0.10	lasso	7	0.09	1.4e-06	-5.57	5.8	8.4e-09	-0.19	0.11	0.89	FALSE
3	GTEx	Adipose Subcutaneous	RP11-23P13.7	0.44	0.09	enet	77	0.12	1.0e-09	-0.53	-5.5	3.3e-08	0.29	1.00	0.00	FALSE
15	NTR	Blood	RTF1	0.04	0.02	blup	338	0.03	6.9e-09	5.74	-5.5	4.2e-08	0.13	1.00	0.00	FALSE
12	GTEx	Thyroid	PLA2G4B	0.14	0.09	enet	11	0.08	1.6e-06	2.45	5.4	7.9e-08	-0.05	0.99	0.00	FALSE
6	GTEx	Brain Cerebellum	MAPKBP1	0.23	0.09	lasso	8	0.12	2.2e-04	2.65	-5.2	2.2e-07	0.07	0.34	0.23	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	PLCB2	0.11	0.14	lasso	1	0.13	6.5e-08	-5.14	-5.1	2.8e-07	0.01	0.00	1.00	FALSE