Best TWAS P=1.98e-41 · Best GWAS P=1.29e-43 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDAN1 | 0.04 | 0.02 | blup | 278 | 0.02 | 7.8e-04 | -4.42 | -5.4 | 7.0e-08 | 0.12 | 0.03 | 0.90 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | EHD4 | 0.25 | 0.00 | enet | 39 | 0.07 | 2.0e-06 | -2.10 | -8.3 | 6.6e-17 | 0.37 | 0.17 | 0.19 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RP11-23P13.7 | 0.44 | 0.09 | enet | 77 | 0.12 | 1.0e-09 | -0.53 | -5.5 | 3.3e-08 | 0.29 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adrenal Gland | LTK | 0.21 | 0.05 | enet | 21 | 0.06 | 3.9e-03 | -3.10 | 7.0 | 2.7e-12 | -0.27 | 0.16 | 0.21 | TRUE |
| 5 | GTEx | Artery Tibial | EHD4 | 0.14 | 0.03 | enet | 21 | 0.06 | 1.0e-05 | 4.24 | -8.0 | 1.4e-15 | 0.17 | 0.80 | 0.01 | FALSE |
| 6 | GTEx | Brain Cerebellum | MAPKBP1 | 0.23 | 0.09 | lasso | 8 | 0.12 | 2.2e-04 | 2.65 | -5.2 | 2.2e-07 | 0.07 | 0.34 | 0.23 | FALSE |
| 7 | GTEx | Brain Nucleus accumbens basal ganglia | SPTBN5 | 0.37 | 0.21 | lasso | 5 | 0.27 | 5.4e-08 | -2.04 | -6.2 | 4.8e-10 | 0.54 | 0.09 | 0.66 | FALSE |
| 8 | GTEx | Esophagus Mucosa | CHP1 | 0.19 | 0.10 | lasso | 7 | 0.09 | 1.4e-06 | -5.57 | 5.8 | 8.4e-09 | -0.19 | 0.11 | 0.89 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | RP11-23P13.6 | 0.26 | -0.01 | enet | 13 | 0.01 | 8.6e-02 | 4.20 | -6.3 | 3.6e-10 | 0.15 | 0.09 | 0.06 | FALSE |
| 10 | GTEx | Nerve Tibial | EHD4 | 0.20 | 0.04 | lasso | 7 | 0.08 | 2.4e-06 | 3.02 | -9.2 | 3.2e-20 | 0.21 | 0.92 | 0.04 | TRUE |
| 11 | GTEx | Thyroid | RTF1 | 0.28 | 0.27 | lasso | 3 | 0.26 | 8.4e-20 | 6.37 | 6.4 | 1.7e-10 | -0.20 | 1.00 | 0.00 | TRUE |
| 12 | GTEx | Thyroid | PLA2G4B | 0.14 | 0.09 | enet | 11 | 0.08 | 1.6e-06 | 2.45 | 5.4 | 7.9e-08 | -0.05 | 0.99 | 0.00 | FALSE |
| 13 | METSIM | Adipose | EHD4 | 0.10 | 0.05 | lasso | 2 | 0.03 | 1.0e-05 | -13.62 | -13.5 | 2.0e-41 | 0.95 | 0.00 | 1.00 | TRUE |
| 14 | METSIM | Adipose | PLCB2 | 0.14 | 0.09 | bslmm | 401 | 0.09 | 6.2e-13 | -5.14 | -5.6 | 2.5e-08 | -0.01 | 0.00 | 1.00 | TRUE |
| 15 | NTR | Blood | RTF1 | 0.04 | 0.02 | blup | 338 | 0.03 | 6.9e-09 | 5.74 | -5.5 | 4.2e-08 | 0.13 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EHD4 | 0.04 | 0.02 | blup | 102 | 0.02 | 1.4e-04 | 11.02 | -8.9 | 8.2e-19 | 0.52 | 0.04 | 0.72 | FALSE |
| 17 | The Cancer Genome Atlas | Colon Adenocarcinoma | PLCB2 | 0.11 | 0.14 | lasso | 1 | 0.13 | 6.5e-08 | -5.14 | -5.1 | 2.8e-07 | 0.01 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EHD4 | 0.17 | 0.09 | blup | 101 | 0.09 | 6.8e-10 | 5.17 | -9.2 | 5.4e-20 | 0.56 | 0.97 | 0.02 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | RTF1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.0e-03 | 6.37 | 6.1 | 8.4e-10 | -0.21 | 0.00 | 0.98 | FALSE |