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chr15:63,687,200-66,011,630

Best TWAS P=3.79e-24 · Best GWAS P=4.6e-27 conditioned to 0.00372

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Cells Transformed fibroblasts	CSNK1G1	0.17	0.17	lasso	1	0.15	1.3e-11	-10.14	-10.1	3.8e-24	0.65	0.49	0.51	TRUE
9	GTEx	Cells EBV-transformed lymphocytes	SNX1	0.26	0.24	enet	8	0.23	4.6e-08	-4.22	-5.4	7.0e-08	0.14	0.77	0.04	TRUE
8	GTEx	Breast Mammary Tissue (Female)	SNX1	0.04	-0.01	lasso	3	0.04	3.0e-02	-10.04	-10.0	1.1e-23	0.65	0.03	0.09	FALSE
38	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIP4	0.05	0.01	blup	41	0.03	1.2e-02	-10.10	-9.9	3.7e-23	0.67	0.03	0.33	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRIP4	0.08	0.05	enet	10	0.07	3.3e-08	-10.10	-9.3	1.4e-20	0.65	0.50	0.49	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PPIB	0.06	0.04	lasso	5	0.03	9.8e-05	-9.36	9.2	2.7e-20	-0.55	0.08	0.69	FALSE
40	The Cancer Genome Atlas	Glioblastoma Multiforme	SNX1	0.17	0.04	blup	34	0.04	2.0e-02	-6.00	-9.0	2.5e-19	0.59	0.02	0.24	FALSE
4	GTEx	Adrenal Gland	TRIP4	0.09	0.02	lasso	6	0.00	2.9e-01	-6.08	-8.9	5.6e-19	0.72	0.10	0.23	FALSE
18	GTEx	Heart Atrial Appendage	TRIP4	0.13	0.01	lasso	5	0.04	4.9e-03	-7.26	-8.0	1.0e-15	0.54	0.21	0.15	FALSE
20	GTEx	Lung	TRIP4	0.15	0.05	enet	26	0.14	1.2e-10	-7.23	-7.8	6.5e-15	0.50	0.86	0.13	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX22	0.04	0.03	blup	26	0.03	2.0e-04	-9.36	7.8	7.2e-15	-0.48	0.04	0.40	FALSE
19	GTEx	Heart Left Ventricle	TRIP4	0.09	0.00	enet	8	0.02	1.9e-02	-7.22	-7.7	1.3e-14	0.60	0.21	0.17	FALSE
27	GTEx	Whole Blood	RBPMS2	0.32	0.25	lasso	12	0.24	5.9e-22	-7.40	-7.6	2.4e-14	0.74	1.00	0.00	FALSE
29	METSIM	Adipose	SNX1	0.04	0.03	enet	27	0.03	1.3e-05	-7.24	-7.5	5.1e-14	0.41	0.98	0.02	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRIP4	0.21	0.15	lasso	9	0.12	1.2e-05	-7.24	-7.5	8.4e-14	0.43	0.64	0.07	FALSE
31	NTR	Blood	RBPMS2	0.09	0.18	bslmm	276	0.18	1.2e-56	-7.50	-7.4	1.3e-13	0.76	1.00	0.00	FALSE
34	YFS	Blood	RBPMS2	0.16	0.29	bslmm	268	0.29	1.1e-96	-7.52	-7.4	1.3e-13	0.76	1.00	0.00	FALSE
17	GTEx	Esophagus Muscularis	TRIP4	0.17	0.18	lasso	10	0.16	7.3e-10	-7.19	-7.3	2.0e-13	0.45	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	TRIP4	0.05	0.00	enet	6	0.03	1.9e-03	-7.16	-7.3	2.7e-13	0.45	0.04	0.13	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIP4	0.04	0.06	lasso	2	0.05	7.9e-07	-7.24	-7.2	4.5e-13	0.40	0.92	0.05	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIP4	0.04	0.02	lasso	4	0.01	1.7e-02	-7.24	-7.2	4.7e-13	0.40	0.29	0.03	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIP4	0.06	0.04	enet	7	0.06	8.2e-05	-7.24	-7.2	5.1e-13	0.41	0.67	0.02	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBPMS2	0.04	0.00	blup	33	0.02	5.0e-03	-7.24	-7.2	6.0e-13	0.45	0.02	0.21	FALSE
3	GTEx	Adipose Visceral Omentum	TRIP4	0.13	0.09	lasso	2	0.06	5.9e-04	-7.19	-7.2	8.1e-13	0.43	0.53	0.09	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIP4	0.08	0.03	blup	41	0.04	1.3e-03	-2.47	-7.2	8.6e-13	0.40	0.12	0.11	FALSE
30	METSIM	Adipose	TRIP4	0.10	0.18	lasso	12	0.18	9.0e-26	-7.24	-7.1	9.7e-13	0.39	1.00	0.00	FALSE
21	GTEx	Muscle Skeletal	TRIP4	0.03	0.01	enet	3	0.01	1.5e-02	-7.19	-7.1	1.2e-12	0.32	0.44	0.12	FALSE
33	YFS	Blood	CSNK1G1	0.01	0.00	bslmm	330	0.00	3.0e-02	-8.91	-7.1	1.2e-12	0.47	0.08	0.06	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	TRIP4	0.17	0.21	lasso	3	0.16	4.7e-06	-7.19	-7.1	1.7e-12	0.39	0.58	0.11	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	TRIP4	0.22	0.09	lasso	3	0.06	8.4e-03	-7.19	-7.0	1.8e-12	0.42	0.11	0.23	FALSE
12	GTEx	Cells Transformed fibroblasts	RBPMS2	0.07	0.01	lasso	7	0.01	4.3e-02	-6.08	-7.0	2.7e-12	0.63	0.30	0.10	FALSE
57	The Cancer Genome Atlas	Rectum Adenocarcinoma	SNX1	0.11	0.12	blup	34	0.13	7.2e-04	-5.59	-7.0	2.9e-12	0.52	0.05	0.26	FALSE
22	GTEx	Nerve Tibial	TRIP4	0.09	0.08	lasso	2	0.07	8.9e-06	-7.19	-7.0	3.6e-12	0.40	0.98	0.00	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	SNX22	0.05	0.07	blup	26	0.06	1.3e-06	-4.53	-6.9	4.1e-12	0.57	0.96	0.02	FALSE
2	GTEx	Adipose Subcutaneous	TRIP4	0.12	0.08	lasso	2	0.06	5.6e-06	-7.19	-6.8	8.8e-12	0.39	0.99	0.00	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RBPMS2	0.05	0.03	lasso	7	0.04	1.6e-05	-7.65	-6.8	8.8e-12	0.69	0.01	0.99	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	TRIP4	0.11	0.04	lasso	2	0.04	2.5e-03	-7.19	-6.7	1.9e-11	0.36	0.21	0.10	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TRIP4	0.07	0.06	bslmm	316	0.06	2.2e-07	-6.69	-6.7	2.5e-11	0.27	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIP4	0.10	0.07	enet	7	0.10	2.1e-11	-2.47	-6.7	2.6e-11	0.31	0.79	0.21	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRIP4	0.13	0.07	enet	10	0.08	1.5e-08	-7.24	-6.6	3.8e-11	0.30	0.99	0.01	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TRIP4	0.11	0.06	lasso	5	0.05	2.4e-05	-7.19	-6.5	7.0e-11	0.32	0.69	0.25	FALSE
7	GTEx	Breast Mammary Tissue	TRIP4	0.14	0.05	enet	6	0.03	6.9e-03	-7.23	-6.5	8.3e-11	0.32	0.88	0.02	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRIP4	0.16	0.04	blup	41	0.10	4.7e-05	-10.07	-6.4	1.3e-10	0.21	0.18	0.17	FALSE
14	GTEx	Colon Transverse	TRIP4	0.12	0.10	lasso	2	0.08	9.8e-05	-7.19	-6.4	1.4e-10	0.33	0.90	0.01	FALSE
32	NTR	Blood	SNX1	0.03	0.02	lasso	1	0.02	6.7e-07	-6.40	-6.4	1.6e-10	0.40	0.98	0.01	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX1	0.04	0.05	enet	8	0.04	1.1e-03	-5.59	-6.3	3.4e-10	0.37	0.08	0.07	FALSE
36	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIP4	0.08	0.06	enet	5	0.06	1.0e-05	-7.16	-6.2	6.8e-10	0.29	0.91	0.04	FALSE
25	GTEx	Testis	TRIP4	0.12	0.06	lasso	5	0.06	1.6e-03	-7.14	-6.0	1.5e-09	0.29	0.16	0.06	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIP4	0.16	0.08	lasso	5	0.08	2.3e-09	-7.23	-6.0	1.9e-09	0.26	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIP4	0.10	0.05	enet	10	0.06	3.4e-12	-7.23	-6.0	2.7e-09	0.21	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TRIP4	0.08	0.00	enet	9	0.05	3.3e-03	-10.10	-5.8	5.3e-09	0.47	0.02	0.15	FALSE
16	GTEx	Esophagus Mucosa	TRIP4	0.15	0.08	lasso	6	0.12	1.6e-08	-7.23	-5.8	7.4e-09	0.28	1.00	0.00	FALSE
26	GTEx	Whole Blood	SNX1	0.09	0.02	lasso	2	0.02	1.3e-02	-4.01	-5.8	8.6e-09	0.34	0.11	0.03	FALSE
41	The Cancer Genome Atlas	Glioblastoma Multiforme	TRIP4	0.37	0.21	enet	9	0.26	1.8e-08	-7.24	-5.8	8.7e-09	0.24	0.97	0.01	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	TRIP4	0.17	0.14	lasso	6	0.15	3.4e-06	-7.14	-5.7	9.2e-09	0.24	0.76	0.02	FALSE
5	GTEx	Brain Caudate basal ganglia	TRIP4	0.18	0.05	lasso	5	0.07	3.7e-03	-7.19	-5.6	1.8e-08	0.26	0.31	0.11	FALSE
35	YFS	Blood	TRIP4	0.08	0.08	blup	301	0.08	2.0e-24	-7.26	-5.6	2.6e-08	0.26	1.00	0.00	FALSE
28	METSIM	Adipose	MTFMT	0.03	0.01	bslmm	305	0.01	2.6e-02	-1.73	-5.4	6.9e-08	0.16	0.15	0.20	FALSE
58	The Cancer Genome Atlas	Soft Tissue Sarcoma	PIF1	0.16	0.02	blup	33	0.10	1.1e-06	0.17	-5.2	1.6e-07	0.22	0.36	0.08	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX1	0.11	0.05	blup	34	0.05	1.7e-06	-5.59	-5.2	1.7e-07	0.29	0.70	0.26	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	SNX1	0.09	0.13	lasso	5	0.12	5.8e-12	-4.53	-5.2	1.9e-07	0.40	1.00	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	TRIP4	0.47	0.36	lasso	3	0.47	1.7e-39	-7.19	-5.2	2.2e-07	0.20	1.00	0.00	FALSE