Best TWAS P=3.32e-29 · Best GWAS P=4.44e-34 conditioned to 2.08e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | SRR | 0.38 | 0.37 | lasso | 6 | 0.38 | 8.1e-15 | 3.9 | -5.6 | 2.1e-08 | 0.42 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | CRK | 0.19 | 0.14 | lasso | 6 | 0.18 | 3.5e-14 | -5.5 | -6.3 | 2.3e-10 | 0.01 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | HNRNPA1P16 | 0.22 | -0.01 | enet | 25 | 0.06 | 8.6e-03 | 4.4 | -7.7 | 1.6e-14 | 0.28 | 0.06 | 0.28 | FALSE |
| 4 | GTEx | Brain Hypothalamus | SCARF1 | 0.38 | -0.01 | enet | 14 | 0.04 | 3.4e-02 | -6.0 | -5.8 | 6.4e-09 | 0.27 | 0.06 | 0.12 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RTN4RL1 | 0.13 | 0.04 | lasso | 4 | 0.04 | 2.9e-04 | -2.9 | -5.5 | 4.8e-08 | 0.18 | 0.26 | 0.22 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | RP11-667K14.4 | 0.12 | 0.12 | lasso | 5 | 0.11 | 2.1e-08 | -8.2 | -8.1 | 5.4e-16 | 0.49 | 0.97 | 0.03 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | CRK | 0.24 | 0.08 | lasso | 4 | 0.06 | 4.2e-03 | -5.4 | -5.4 | 6.5e-08 | -0.02 | 0.07 | 0.32 | FALSE |
| 8 | GTEx | Esophagus Mucosa | SGSM2 | 0.28 | 0.32 | lasso | 5 | 0.32 | 6.9e-22 | -5.9 | 5.2 | 2.4e-07 | -0.23 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Esophagus Mucosa | RP1-59D14.5 | 0.14 | 0.15 | lasso | 2 | 0.14 | 1.3e-09 | -5.9 | 5.8 | 6.6e-09 | -0.25 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Esophagus Muscularis | CRK | 0.20 | 0.20 | enet | 16 | 0.21 | 4.0e-13 | -5.5 | -5.8 | 5.0e-09 | 0.03 | 0.83 | 0.17 | FALSE |
| 11 | GTEx | Nerve Tibial | CRK | 0.23 | 0.12 | lasso | 6 | 0.17 | 2.5e-12 | -5.4 | -6.3 | 3.4e-10 | 0.00 | 0.31 | 0.69 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | MNT | 0.10 | 0.09 | enet | 16 | 0.08 | 5.1e-07 | -3.7 | -5.3 | 1.3e-07 | 0.16 | 0.97 | 0.00 | FALSE |
| 13 | GTEx | Spleen | SRR | 0.21 | 0.10 | lasso | 4 | 0.04 | 3.1e-02 | 3.9 | -5.5 | 3.6e-08 | 0.42 | 0.05 | 0.67 | FALSE |
| 14 | GTEx | Stomach | CRK | 0.18 | 0.06 | lasso | 5 | 0.08 | 1.8e-04 | 4.1 | -5.9 | 3.1e-09 | 0.00 | 0.02 | 0.97 | FALSE |
| 15 | GTEx | Thyroid | YWHAE | 0.10 | 0.01 | lasso | 5 | 0.01 | 4.9e-02 | -7.1 | -6.7 | 2.0e-11 | 0.03 | 0.00 | 0.98 | TRUE |
| 16 | GTEx | Thyroid | CRK | 0.12 | 0.05 | enet | 10 | 0.10 | 5.9e-08 | -5.3 | -6.3 | 3.7e-10 | 0.02 | 0.02 | 0.98 | FALSE |
| 17 | METSIM | Adipose | SRR | 0.07 | 0.07 | enet | 21 | 0.06 | 4.4e-09 | 3.9 | -6.2 | 5.0e-10 | 0.46 | 1.00 | 0.00 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | CRK | 0.08 | 0.08 | lasso | 7 | 0.07 | 1.3e-09 | -5.7 | -5.8 | 5.4e-09 | 0.03 | 0.94 | 0.06 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SMG6 | 0.03 | 0.01 | blup | 144 | 0.01 | 4.8e-03 | -4.8 | -11.2 | 3.3e-29 | 0.68 | 0.15 | 0.37 | TRUE |
| 20 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SMG6 | 0.08 | 0.05 | blup | 144 | 0.07 | 1.3e-04 | -8.1 | -10.8 | 4.9e-27 | 0.72 | 0.11 | 0.83 | FALSE |
| 21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CRK | 0.13 | 0.00 | blup | 49 | 0.05 | 3.7e-03 | -3.8 | -6.5 | 1.1e-10 | -0.01 | 0.01 | 0.75 | FALSE |
| 22 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SRR | 0.16 | 0.03 | blup | 61 | 0.02 | 8.7e-02 | 4.2 | -7.1 | 1.2e-12 | 0.48 | 0.01 | 0.62 | FALSE |
| 23 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SGSM2 | 0.13 | 0.01 | blup | 81 | 0.01 | 1.1e-01 | -8.2 | 5.9 | 3.7e-09 | -0.45 | 0.01 | 0.67 | FALSE |