[Hub]/) : Traits : Blood White Count :

chr17:554,080-3,000,009

Best TWAS P=3.32e-29 · Best GWAS P=4.44e-34 conditioned to 2.08e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adrenal Gland SRR 0.38 0.37 lasso 6 0.38 8.1e-15 3.9 -5.6 2.1e-08 0.42 1.00 0.00 FALSE
2 GTEx Artery Tibial CRK 0.19 0.14 lasso 6 0.18 3.5e-14 -5.5 -6.3 2.3e-10 0.01 0.10 0.90 FALSE
3 GTEx Brain Frontal Cortex BA9 HNRNPA1P16 0.22 -0.01 enet 25 0.06 8.6e-03 4.4 -7.7 1.6e-14 0.28 0.06 0.28 FALSE
4 GTEx Brain Hypothalamus SCARF1 0.38 -0.01 enet 14 0.04 3.4e-02 -6.0 -5.8 6.4e-09 0.27 0.06 0.12 FALSE
5 GTEx Cells Transformed fibroblasts RTN4RL1 0.13 0.04 lasso 4 0.04 2.9e-04 -2.9 -5.5 4.8e-08 0.18 0.26 0.22 TRUE
6 GTEx Cells Transformed fibroblasts RP11-667K14.4 0.12 0.12 lasso 5 0.11 2.1e-08 -8.2 -8.1 5.4e-16 0.49 0.97 0.03 FALSE
7 GTEx Esophagus Gastroesophageal Junction CRK 0.24 0.08 lasso 4 0.06 4.2e-03 -5.4 -5.4 6.5e-08 -0.02 0.07 0.32 FALSE
8 GTEx Esophagus Mucosa SGSM2 0.28 0.32 lasso 5 0.32 6.9e-22 -5.9 5.2 2.4e-07 -0.23 1.00 0.00 FALSE
9 GTEx Esophagus Mucosa RP1-59D14.5 0.14 0.15 lasso 2 0.14 1.3e-09 -5.9 5.8 6.6e-09 -0.25 1.00 0.00 FALSE
10 GTEx Esophagus Muscularis CRK 0.20 0.20 enet 16 0.21 4.0e-13 -5.5 -5.8 5.0e-09 0.03 0.83 0.17 FALSE
11 GTEx Nerve Tibial CRK 0.23 0.12 lasso 6 0.17 2.5e-12 -5.4 -6.3 3.4e-10 0.00 0.31 0.69 FALSE
12 GTEx Skin Sun Exposed Lower leg MNT 0.10 0.09 enet 16 0.08 5.1e-07 -3.7 -5.3 1.3e-07 0.16 0.97 0.00 FALSE
13 GTEx Spleen SRR 0.21 0.10 lasso 4 0.04 3.1e-02 3.9 -5.5 3.6e-08 0.42 0.05 0.67 FALSE
14 GTEx Stomach CRK 0.18 0.06 lasso 5 0.08 1.8e-04 4.1 -5.9 3.1e-09 0.00 0.02 0.97 FALSE
15 GTEx Thyroid YWHAE 0.10 0.01 lasso 5 0.01 4.9e-02 -7.1 -6.7 2.0e-11 0.03 0.00 0.98 TRUE
16 GTEx Thyroid CRK 0.12 0.05 enet 10 0.10 5.9e-08 -5.3 -6.3 3.7e-10 0.02 0.02 0.98 FALSE
17 METSIM Adipose SRR 0.07 0.07 enet 21 0.06 4.4e-09 3.9 -6.2 5.0e-10 0.46 1.00 0.00 FALSE
18 ROSMAP Brain Pre-frontal Cortex CRK 0.08 0.08 lasso 7 0.07 1.3e-09 -5.7 -5.8 5.4e-09 0.03 0.94 0.06 FALSE
19 The Cancer Genome Atlas Breast Invasive Carcinoma SMG6 0.03 0.01 blup 144 0.01 4.8e-03 -4.8 -11.2 3.3e-29 0.68 0.15 0.37 TRUE
20 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SMG6 0.08 0.05 blup 144 0.07 1.3e-04 -8.1 -10.8 4.9e-27 0.72 0.11 0.83 FALSE
21 The Cancer Genome Atlas Pancreatic Adenocarcinoma CRK 0.13 0.00 blup 49 0.05 3.7e-03 -3.8 -6.5 1.1e-10 -0.01 0.01 0.75 FALSE
22 The Cancer Genome Atlas Skin Cutaneous Melanoma SRR 0.16 0.03 blup 61 0.02 8.7e-02 4.2 -7.1 1.2e-12 0.48 0.01 0.62 FALSE
23 The Cancer Genome Atlas Testicular Germ Cell Tumors SGSM2 0.13 0.01 blup 81 0.01 1.1e-01 -8.2 5.9 3.7e-09 -0.45 0.01 0.67 FALSE