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chr17:554,080-3,000,009

Best TWAS P=3.32e-29 · Best GWAS P=4.44e-34 conditioned to 2.08e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMG6	0.03	0.01	blup	144	0.01	4.8e-03	-4.8	-11.2	3.3e-29	0.68	0.15	0.37	TRUE
15	GTEx	Thyroid	YWHAE	0.10	0.01	lasso	5	0.01	4.9e-02	-7.1	-6.7	2.0e-11	0.03	0.00	0.98	TRUE
5	GTEx	Cells Transformed fibroblasts	RTN4RL1	0.13	0.04	lasso	4	0.04	2.9e-04	-2.9	-5.5	4.8e-08	0.18	0.26	0.22	TRUE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMG6	0.08	0.05	blup	144	0.07	1.3e-04	-8.1	-10.8	4.9e-27	0.72	0.11	0.83	FALSE
6	GTEx	Cells Transformed fibroblasts	RP11-667K14.4	0.12	0.12	lasso	5	0.11	2.1e-08	-8.2	-8.1	5.4e-16	0.49	0.97	0.03	FALSE
3	GTEx	Brain Frontal Cortex BA9	HNRNPA1P16	0.22	-0.01	enet	25	0.06	8.6e-03	4.4	-7.7	1.6e-14	0.28	0.06	0.28	FALSE
22	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SRR	0.16	0.03	blup	61	0.02	8.7e-02	4.2	-7.1	1.2e-12	0.48	0.01	0.62	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CRK	0.13	0.00	blup	49	0.05	3.7e-03	-3.8	-6.5	1.1e-10	-0.01	0.01	0.75	FALSE
2	GTEx	Artery Tibial	CRK	0.19	0.14	lasso	6	0.18	3.5e-14	-5.5	-6.3	2.3e-10	0.01	0.10	0.90	FALSE
11	GTEx	Nerve Tibial	CRK	0.23	0.12	lasso	6	0.17	2.5e-12	-5.4	-6.3	3.4e-10	0.00	0.31	0.69	FALSE
16	GTEx	Thyroid	CRK	0.12	0.05	enet	10	0.10	5.9e-08	-5.3	-6.3	3.7e-10	0.02	0.02	0.98	FALSE
17	METSIM	Adipose	SRR	0.07	0.07	enet	21	0.06	4.4e-09	3.9	-6.2	5.0e-10	0.46	1.00	0.00	FALSE
14	GTEx	Stomach	CRK	0.18	0.06	lasso	5	0.08	1.8e-04	4.1	-5.9	3.1e-09	0.00	0.02	0.97	FALSE
23	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SGSM2	0.13	0.01	blup	81	0.01	1.1e-01	-8.2	5.9	3.7e-09	-0.45	0.01	0.67	FALSE
10	GTEx	Esophagus Muscularis	CRK	0.20	0.20	enet	16	0.21	4.0e-13	-5.5	-5.8	5.0e-09	0.03	0.83	0.17	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	CRK	0.08	0.08	lasso	7	0.07	1.3e-09	-5.7	-5.8	5.4e-09	0.03	0.94	0.06	FALSE
4	GTEx	Brain Hypothalamus	SCARF1	0.38	-0.01	enet	14	0.04	3.4e-02	-6.0	-5.8	6.4e-09	0.27	0.06	0.12	FALSE
9	GTEx	Esophagus Mucosa	RP1-59D14.5	0.14	0.15	lasso	2	0.14	1.3e-09	-5.9	5.8	6.6e-09	-0.25	1.00	0.00	FALSE
1	GTEx	Adrenal Gland	SRR	0.38	0.37	lasso	6	0.38	8.1e-15	3.9	-5.6	2.1e-08	0.42	1.00	0.00	FALSE
13	GTEx	Spleen	SRR	0.21	0.10	lasso	4	0.04	3.1e-02	3.9	-5.5	3.6e-08	0.42	0.05	0.67	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	CRK	0.24	0.08	lasso	4	0.06	4.2e-03	-5.4	-5.4	6.5e-08	-0.02	0.07	0.32	FALSE
12	GTEx	Skin Sun Exposed Lower leg	MNT	0.10	0.09	enet	16	0.08	5.1e-07	-3.7	-5.3	1.3e-07	0.16	0.97	0.00	FALSE
8	GTEx	Esophagus Mucosa	SGSM2	0.28	0.32	lasso	5	0.32	6.9e-22	-5.9	5.2	2.4e-07	-0.23	1.00	0.00	FALSE