Hub : Genes

RP1-59D14.5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.070	0.0360	5.8e-03	0.018	NA	0.054	NA	0.043	1.2e-02	NA	3.1e-05	NA	2.0e-04
2	GTEx	Artery Aorta	0.182	0.0680	4.8e-03	0.021	NA	0.066	NA	0.042	2.5e-02	NA	1.7e-04	NA	2.2e-03
3	GTEx	Artery Tibial	0.172	0.0534	1.2e-05	0.132	NA	0.084	NA	0.086	1.8e-10	NA	3.8e-07	NA	2.9e-07
4	GTEx	Colon Transverse	0.222	0.0880	6.5e-03	0.135	NA	0.108	NA	0.114	5.6e-07	NA	8.4e-06	NA	4.5e-06
5	GTEx	Esophagus Mucosa	0.144	0.0570	6.9e-04	0.153	NA	0.132	NA	0.140	2.2e-10	NA	4.3e-09	NA	1.3e-09
6	GTEx	Esophagus Muscularis	0.169	0.0640	1.8e-03	0.020	NA	0.091	NA	0.072	2.2e-02	NA	3.4e-06	NA	3.6e-05
7	GTEx	Lung	0.250	0.0651	2.1e-04	-0.003	NA	0.016	NA	0.002	6.9e-01	NA	1.9e-02	NA	2.0e-01
8	GTEx	Nerve Tibial	0.195	0.0653	9.7e-04	0.058	NA	0.028	NA	0.069	6.3e-05	NA	4.2e-03	NA	1.2e-05
9	GTEx	Skin Not Sun Exposed Suprapubic	0.293	0.0740	1.9e-05	0.247	NA	0.295	NA	0.277	9.0e-14	NA	1.3e-16	NA	1.6e-15
10	GTEx	Skin Sun Exposed Lower leg	0.319	0.0780	1.1e-06	0.277	NA	0.271	NA	0.303	4.5e-23	NA	1.7e-22	NA	1.8e-25
11	GTEx	Stomach	0.137	0.0570	2.8e-03	0.039	NA	0.059	NA	0.056	5.7e-03	NA	8.5e-04	NA	1.2e-03
12	GTEx	Thyroid	0.232	0.0650	3.1e-04	0.044	NA	0.109	NA	0.063	2.5e-04	NA	1.1e-08	NA	1.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.2	0.4	1.2	-0.9	0.1	-0.4	-0.1	0.6	0.0	-0.1	-1.1	0.4	0.6	0.0	-1.1
Bipolar Disorder or Schizophrenia	1.4	3.3	6.3	-2.5	0.2	-1.4	-1.1	2.5	-0.8	0.9	-1.7	2.4	2.3	-2.2	-1.9
Depressed Affect (Nagel 2018)	1.3	2.8	10.9	0.6	-3.3	-1.4	-1.2	-0.4	-1.3	1.9	-1.2	-0.8	-1.2	-2.6	-1.7
Depression (Nagel 2018)	0.7	1.1	4.0	1.3	-2.0	-0.8	-0.7	-0.8	-0.3	1.0	-0.6	-0.1	-1.2	-1.6	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.0	0.2	1.2	0.8	0.7	0.4	1.6	0.3	0.6	1.5	0.9	2.0	1.0
Neuroticism (Nagel 2018)	1.9	4.4	15.4	0.2	-3.9	-2.2	-2.0	0.2	-0.8	2.4	-1.7	-1.5	-1.0	-3.3	-2.4
Schizophrenia (2018)	1.9	3.9	8.7	-3.0	-0.1	-1.5	-1.3	2.7	-1.1	0.6	-1.3	2.8	2.5	-2.9	-1.3
Schizophrenia vs Biploar Disorder	1.2	1.5	3.8	-0.8	-1.6	-1.9	-2.0	1.1	0.0	1.7	-0.6	0.2	0.4	-1.7	-0.4
Worry (Nagel 2018)	1.1	2.3	10.2	0.4	-3.2	-0.7	-0.6	-0.3	0.5	1.8	-0.6	-2.3	-1.4	-1.4	-1.8
Alzheimer’s Disease (in mother)	0.1	0.2	0.8	-0.1	-0.2	0.3	0.1	0.3	0.6	0.1	0.1	0.9	0.4	0.3	0.3
Alzheimer’s Disease (in father)	1.0	1.1	3.9	0.5	2.0	1.0	0.9	0.3	0.7	1.0	1.1	0.2	0.3	1.4	1.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.5	0.1	1.2	0.9	0.7	-0.1	0.6	0.8	0.8	0.2	-0.1	1.2	0.7
Crohns Disease (2017)	0.8	1.8	6.5	0.0	0.3	-1.4	-1.6	1.7	-0.1	-1.5	-0.6	2.5	2.0	-0.8	-0.7
Irritable Bowel Disease (IBD)	1.3	3.0	11.5	-1.0	0.3	-1.2	-0.9	2.4	-0.1	-1.7	-1.9	3.4	2.9	-0.6	-1.1
Ulcerative Colitis (UC)	1.0	1.8	6.9	-1.1	0.4	-0.5	-0.1	1.8	0.2	-1.0	-1.6	2.6	2.4	0.4	-0.6
Major Depression (MDD)	0.2	0.2	1.6	0.3	0.2	-0.1	-0.0	-0.6	-0.7	0.0	0.2	0.4	-0.3	0.0	1.3
Reaction Time	0.5	0.9	2.2	-0.6	0.1	1.3	1.5	-1.1	1.4	-1.3	0.4	-0.2	-0.9	0.9	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	3.1	0.7	-0.6	0.7	0.6	-0.0	0.5	0.9	0.0	-0.1	-0.1	1.8	0.1
Breast Cancer	0.2	0.6	4.3	-0.2	-0.3	-0.1	-0.5	0.2	-1.0	0.6	0.6	0.1	0.0	-2.1	0.9
Ovarian Cancer	1.2	1.6	4.4	-1.8	-0.2	-0.9	-0.5	-0.8	-1.8	-2.1	-1.7	-0.4	-0.6	-1.0	-1.5
Prostate Cancer	0.4	0.6	2.1	0.5	0.6	0.9	0.7	-0.5	1.1	-0.6	0.7	-0.4	-0.3	1.5	-0.4
Age at First Birth	1.1	1.6	6.4	0.7	0.6	1.2	0.7	0.0	0.9	2.5	1.4	-0.2	0.1	1.9	1.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.0	0.5	-1.0	0.4	0.6	-1.2	-0.9	-1.0	-0.9	-0.9	-1.4	-0.1	0.0
Coronary Artery Disease (CAD)	0.6	0.7	3.5	1.9	-0.5	1.0	1.2	-1.0	0.0	0.2	0.2	-0.6	-0.9	0.5	0.3
Crohns Disease (2012)	0.8	1.3	3.4	0.4	0.6	-0.9	-1.1	1.7	-0.4	-1.0	-0.3	1.8	1.9	-0.9	-1.0
Mean Putamen Volume	0.5	0.6	1.8	-0.6	-0.7	-0.2	0.2	0.8	-1.3	0.2	-0.9	-0.1	0.6	-1.0	-1.1
Fasting Glucose	0.2	0.3	1.1	-0.2	1.0	-0.7	-0.5	-0.0	-0.7	0.2	-0.6	-0.7	-0.3	-0.3	0.3
HbA1C	0.7	0.7	3.9	0.5	0.3	0.5	0.2	0.1	0.1	2.0	0.8	0.7	0.0	0.7	1.7
HDL Cholesterol	1.3	2.1	5.1	-0.8	-1.1	-1.9	-2.2	2.3	-1.3	-0.1	-0.5	1.2	2.0	-1.5	-0.7
LDL Cholesterol	2.0	3.2	7.0	-2.1	-2.6	-2.1	-2.0	1.8	-1.5	-1.1	-1.4	0.8	1.3	-1.4	-2.4
Lupus	0.5	0.8	2.2	-0.7	-1.5	-0.6	-0.5	-0.0	-1.0	1.0	-0.5	1.0	0.1	-1.4	-0.8
Neuroticism (2016)	2.9	4.2	13.0	-1.2	-2.5	-3.0	-2.7	1.1	-2.0	0.6	-2.3	0.6	0.5	-3.6	-1.3
Primary Biliary Cirrhosis	0.7	1.1	3.4	-1.2	0.4	-0.9	-0.3	0.0	-1.7	-0.4	-1.8	1.2	0.7	-1.0	-0.8
Rheumatoid Arthritis	0.3	0.4	1.3	-0.0	-1.1	-0.1	-0.1	-0.1	-0.9	-1.1	-0.2	0.2	-0.4	-0.6	-0.7
Schizophrenia (2014)	2.1	4.6	8.9	-2.9	-0.7	-2.0	-1.8	2.8	-1.2	0.7	-1.5	2.5	2.3	-3.0	-2.4
Triglycerides	0.2	0.4	2.4	-0.7	-0.5	-0.0	-0.1	0.5	0.4	-1.6	0.2	0.1	0.3	0.6	-0.9
Type 2 Diabetes (T2D) (2012)	1.8	2.1	7.7	0.9	2.0	1.9	1.8	-0.9	2.8	0.0	1.4	0.3	-0.5	1.5	0.8
Ulcerative Colitis	2.0	2.9	10.4	-1.3	1.5	-0.6	0.0	2.2	-0.4	-0.4	-2.3	3.2	2.9	0.1	-0.8
Blood Eosinophil Count	1.2	9.4	20.9	3.6	2.2	4.0	3.6	-1.6	4.0	2.5	3.2	-0.5	-1.0	4.6	2.7
Blood Platelet Count	2.2	25.5	97.6	-5.8	-3.7	-5.6	-6.0	9.9	-1.0	4.6	-0.7	3.0	7.0	-3.2	-2.0
Blood Red Count	0.3	2.6	10.8	1.4	1.4	1.0	0.6	-3.3	0.5	-1.6	0.4	-1.1	-2.5	2.3	0.1
Blood White Count	1.1	8.1	33.6	-2.4	-0.2	-2.2	-2.3	5.8	0.9	2.4	-0.7	3.8	5.1	-0.5	-0.8
Heel T-Score	2.6	20.5	65.8	8.1	2.9	4.6	5.1	-7.7	2.9	-1.9	1.3	-2.9	-5.7	1.3	2.9
BMI	0.8	4.6	14.0	3.7	-0.9	1.6	2.1	-3.0	0.6	0.1	0.7	-3.0	-3.6	0.5	1.3
Height	0.1	1.1	2.6	0.6	-1.1	1.6	1.4	-0.5	0.7	-0.1	1.6	1.0	0.0	-0.3	1.6
Waist Hip Ratio (WHR)	1.1	5.0	15.5	2.8	-0.2	2.1	2.1	-3.9	1.4	-0.7	1.4	-2.0	-3.6	2.0	1.3
Systolic Blood Pressure	1.8	8.9	31.5	3.0	-2.0	1.2	0.7	-1.0	4.5	5.6	3.7	-4.1	-2.5	-0.3	1.2
Smoking Status	1.5	3.6	16.0	-0.5	1.4	-1.6	-1.9	1.7	-2.4	-0.9	-0.8	4.0	2.7	-1.1	0.1
Allergy or Eczema	2.3	6.0	16.4	-3.5	0.7	-1.4	-1.1	3.1	-3.2	-1.1	-2.1	4.0	3.6	-1.0	-0.8
Cardiovascular Disease	0.4	1.2	3.2	1.7	-1.8	-1.1	-1.3	-0.5	0.8	-0.6	0.2	-1.4	-0.9	-1.4	-0.2
Hypothyroidism (self reported)	0.3	0.7	2.1	-1.1	-0.2	-0.7	-0.5	0.2	-1.4	-0.2	-1.1	0.7	0.3	-0.5	-1.5
Respiratory disease	0.6	1.4	3.8	1.5	0.9	1.7	1.6	-1.9	0.1	0.1	1.2	-0.0	-1.4	1.2	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.8	0.3	0.7	0.6	0.7	0.1	0.7	0.6	0.6	1.1	0.3	0.5	1.7
Lung FEV1/FVC ratio	1.7	8.7	22.0	-3.7	-1.6	-3.4	-2.9	4.7	-1.8	0.5	-2.0	3.4	4.1	-1.9	-2.5
Lung FVC	1.3	6.5	16.7	3.1	0.8	2.2	2.1	-2.3	4.1	3.1	2.4	-3.3	-2.7	0.9	1.4
Neuroticism	2.3	5.5	15.6	-1.1	-3.8	-3.0	-2.6	0.7	-1.4	1.0	-3.0	-0.2	-0.2	-4.0	-2.4
Chronotype (morning person)	0.1	0.2	0.8	0.2	0.4	0.2	0.3	0.0	0.3	0.1	0.9	0.5	0.2	-0.5	0.5
Hair Pigment	0.1	2.5	5.9	1.5	1.1	2.4	2.4	-2.0	1.1	-1.2	1.6	-0.5	-1.4	2.0	0.2
Tanning	0.1	1.7	4.1	1.7	0.5	1.3	0.9	-0.4	1.1	0.7	2.0	-2.0	-0.8	0.6	2.0
Hand grip strength (left)	2.7	7.0	15.6	3.7	2.2	3.0	2.9	-1.8	4.0	2.0	2.9	-2.2	-1.8	1.3	2.8
Number of treatments/medications taken	0.3	0.5	1.7	0.3	-1.3	-1.0	-1.2	-0.3	-0.5	-0.0	-0.1	0.0	-0.6	-0.8	-0.3
Average weekly spirits intake	1.0	1.3	4.9	1.7	1.1	0.2	-0.2	0.0	0.1	2.0	0.9	0.7	0.3	1.1	2.2
Sensitivity / hurt feelings	1.7	2.9	10.0	-1.3	-2.6	-1.9	-1.8	1.0	-1.1	1.7	-1.7	0.5	0.5	-3.2	-0.9
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.1	1.5	-1.8	-0.3	-0.3	-0.8	-0.7	1.4	0.0	-0.6	-1.3	-1.3	0.7
Hearing difficulty/problems: Yes	2.2	3.3	9.2	0.4	-1.6	-2.8	-2.9	1.5	-1.5	-1.3	-1.4	0.9	1.1	-3.0	-1.3
Relative age of first facial hair	1.5	3.2	6.6	-1.8	-0.9	-2.5	-2.6	1.8	-1.7	-0.9	-1.2	1.6	1.6	-2.5	-1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.6	-0.4	-0.2	0.3	0.4	0.1	-0.2	1.1	0.4	0.2	0.2	-0.4	1.3
Ever used hormone-replacement therapy (HRT)	1.8	2.3	7.6	-0.7	-1.6	-1.5	-2.1	1.6	-1.0	-0.7	0.2	2.8	1.6	-1.8	0.6
Ever had hysterectomy (womb removed)	0.8	0.9	4.0	-0.0	-0.9	-1.3	-1.1	0.1	-0.7	0.7	-1.4	0.5	0.1	-2.0	-0.5
Systolic blood pressure, automated reading	2.3	6.8	21.6	3.3	-1.8	1.9	1.4	-1.2	4.6	3.6	3.2	-2.8	-2.3	0.5	1.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.3	0.3	0.8	0.6	0.6	-0.3	1.1	0.3	0.8	0.2	0.0	-0.0	0.8
Angina	2.0	2.7	8.7	2.9	0.9	1.0	0.9	-1.9	1.8	1.9	1.4	-1.2	-1.7	1.0	1.8
Medication for hormone replacement therapy	0.7	0.8	2.0	1.0	-1.0	-0.8	-1.4	-0.4	0.1	0.8	1.2	-1.0	-0.9	-0.8	0.5
Vitamin and mineral supplements	0.4	0.6	3.6	1.1	-0.7	-0.1	0.1	-0.6	0.3	-1.9	-0.7	-0.5	-0.7	-0.0	-0.1
Supplements: Zinc	0.6	0.6	3.6	-1.9	0.9	-0.7	-0.7	0.1	-1.0	-0.2	-0.8	0.5	0.4	-0.2	-0.4
Medication: Co-codamol	2.7	3.1	5.9	-1.7	-0.5	-2.4	-2.2	1.9	-2.2	0.6	-1.3	2.4	1.8	-1.7	-0.2
Medication: Metformin	0.8	1.1	5.6	0.6	1.8	0.2	0.0	0.4	0.5	0.4	1.3	0.6	0.5	1.2	2.4
Diabetes (father)	1.6	2.0	5.3	-1.8	-1.1	-1.4	-1.3	1.5	-1.1	-2.3	-1.1	1.1	1.4	-0.6	-1.7
Diabetes (mother)	0.2	0.3	1.0	0.3	-0.4	-0.7	-0.6	-0.2	0.4	0.3	-0.7	-1.0	-0.3	0.7	0.1
Severe depression (siblings)	1.9	2.2	6.3	-2.2	-0.9	-1.3	-0.7	0.3	-2.1	-1.1	-2.5	0.8	0.3	-2.0	-1.2
Pack years adult smoking proportion	1.3	2.0	4.7	-1.2	-2.0	-1.9	-2.2	1.9	-1.5	-0.3	-0.5	0.7	1.3	-1.3	-0.1
Impedance of leg (right)	4.0	19.6	43.7	-4.3	-3.1	-5.6	-6.6	6.6	-2.9	1.6	-1.4	4.8	5.9	-4.0	-1.1
Leg fat-free mass (left)	1.6	8.4	18.7	3.4	1.3	3.9	4.3	-4.1	1.5	-0.1	2.0	-2.8	-3.8	2.0	2.2
Trunk fat percentage	0.6	2.3	15.0	0.8	-3.9	-1.0	-1.0	-0.5	-0.9	1.1	0.3	-1.5	-1.6	-1.8	0.2
Hand grip strength (right)	0.8	2.2	5.9	1.5	1.0	1.6	1.6	-1.2	2.4	1.5	1.3	-1.6	-1.4	-0.4	1.4
Townsend deprivation index at recruitment	2.4	3.4	8.3	-1.0	-0.8	-2.1	-2.2	2.8	-2.2	-0.2	-0.9	2.6	2.9	-0.9	-0.9
Current tobacco smoking	2.5	4.1	11.2	-1.5	0.2	-2.1	-2.5	2.9	-2.3	-0.0	-0.9	3.3	3.1	-1.1	0.4
Average weekly fortified wine intake	1.5	1.7	4.7	-1.8	1.2	-0.7	-0.5	1.2	-1.2	-1.5	-1.1	2.2	1.9	-0.5	-0.5
Maternal smoking around birth	1.0	1.5	4.0	-1.0	1.8	-1.7	-2.0	0.6	-1.5	0.2	-0.5	1.2	1.1	-0.6	0.8
Fed-up feelings	1.3	2.3	8.8	-0.2	-0.8	-1.9	-1.6	0.2	-2.7	1.4	-1.4	0.9	0.0	-3.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.5	0.9	-0.9	-0.9	-1.0	0.2	-0.7	1.6	-0.3	1.3	-0.0	-1.4	0.5
Relative age voice broke	1.3	2.0	6.6	-1.6	-1.9	-1.5	-1.7	1.1	-2.6	-0.2	-0.9	1.3	1.2	-0.8	-0.6
Taking other prescription medications	0.8	1.3	3.7	0.4	-1.3	-1.8	-1.9	0.2	-1.9	-0.2	-0.9	0.5	-0.1	-1.3	-0.5
Age when periods started (menarche)	1.9	4.6	9.8	-2.9	-0.8	-3.1	-3.1	2.2	-2.7	-1.2	-1.8	1.4	2.0	-1.0	-1.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	1.1	-1.1	-0.3	-0.6	-0.5	-0.4	0.2	0.2	0.1	-0.3	0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	10.1	3.2	0.1	0.6	0.8	-2.3	-0.4	-1.7	-0.4	-0.6	-1.5	-0.1	-0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.6	0.1	1.6	0.3	0.2	-0.4	-0.1	0.1	0.7	0.4	-0.0	0.5	-0.2
Qualifications: CSEs or equivalent	1.2	1.6	4.5	-0.7	-0.2	-1.4	-1.7	2.1	-1.1	0.8	-0.2	1.7	2.0	-0.3	0.2
Serious illness, injury or assault to yourself	0.4	0.4	3.2	0.2	-0.7	-0.3	-0.4	0.1	0.1	-0.4	-0.0	0.9	0.2	-0.5	1.8
High blood pressure	0.7	1.8	6.8	1.9	-0.7	-0.2	-0.2	-1.8	0.9	-0.4	0.1	-2.6	-2.4	-1.1	0.3
Hayfever, allergic rhinitis or eczema	1.3	2.7	10.3	-1.9	1.1	-0.4	-0.2	2.1	-1.8	-0.4	-1.3	3.2	2.7	-0.1	-0.6
Multivitamins +/- minerals	0.7	0.9	3.3	-0.3	1.2	1.1	0.8	-0.4	0.6	1.8	1.3	-0.3	-0.1	1.2	0.7
Stomach or abdominal pain in last month	0.6	0.8	2.9	-0.8	0.2	-1.0	-0.7	-0.3	-1.1	-0.0	-1.7	0.8	-0.1	-0.5	-1.3
Supplements: Glucosamine	3.9	5.1	9.2	2.3	0.9	2.4	2.4	-3.0	2.2	2.4	2.0	-2.0	-2.8	2.4	1.7
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.8	-0.3	0.8	-1.0	-1.3	1.7	-0.0	0.9	0.1	1.3	1.6	-0.5	1.1
Medication: Atenolol	0.7	0.9	2.8	0.2	0.2	-0.7	-0.4	-1.7	0.4	-0.8	-1.2	-1.4	-1.7	-0.4	-0.4
Medication: Levothyroxine sodium	0.3	0.5	1.4	0.3	0.3	-0.1	-0.2	1.1	0.7	1.1	-0.1	1.0	1.2	-0.1	-0.6
Sitting height	0.6	4.3	9.4	2.7	0.9	2.3	2.3	-0.4	3.1	2.1	2.6	-2.3	-0.9	1.0	2.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.4	0.3	-0.0	0.0	0.7	0.3	-0.6	0.1	0.1	0.6	-0.6	0.7
High blood pressure (mother)	0.8	1.2	6.1	1.7	0.3	-0.9	-1.3	-0.3	0.4	2.5	1.1	-0.6	-0.4	-0.1	0.3
Body mass index (BMI)	0.6	2.5	7.7	2.8	-1.4	0.8	1.1	-2.4	-0.5	0.2	0.5	-1.9	-2.8	-0.2	1.1
Impedance of leg (left)	4.6	22.4	50.0	-5.0	-3.0	-6.0	-6.9	7.1	-3.2	1.2	-1.9	4.9	6.3	-4.5	-1.4
Leg predicted mass (left)	1.6	8.4	19.1	3.4	1.2	3.9	4.4	-4.1	1.4	-0.1	1.9	-2.8	-3.8	2.0	2.1
Trunk fat mass	0.5	2.0	7.8	1.6	-2.8	0.1	0.1	-1.3	-0.5	1.0	0.8	-1.8	-2.2	-1.2	1.1
Waist circumference	0.7	2.6	7.8	2.4	-1.7	1.2	1.4	-2.5	-0.2	0.5	0.7	-1.7	-2.8	0.2	1.4
Number of incorrect matches in round	0.7	1.2	3.3	-0.8	0.6	-1.3	-1.6	1.8	0.0	-0.0	0.1	1.2	1.6	-1.1	0.3
Past tobacco smoking	0.6	1.0	5.4	-0.9	-1.8	0.2	0.4	-0.1	0.2	-0.5	-0.3	-2.3	-1.1	0.9	-0.8
Alcohol usually taken with meals	2.7	4.4	14.1	1.2	2.6	2.9	3.0	-2.0	2.4	-0.8	0.9	-0.5	-1.0	3.8	-0.1
Nervous feelings	1.4	2.6	12.1	0.6	-3.5	-0.2	-0.3	0.8	1.6	3.5	0.3	-0.9	-0.2	-1.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	6.9	-0.8	-2.6	-1.2	-0.8	0.7	-1.5	0.7	-1.5	0.2	0.0	-2.1	-1.8
Hearing difficulty/problems with background noise	4.1	6.5	12.9	-0.8	-1.6	-3.6	-3.2	2.7	-2.5	-1.0	-3.3	3.0	2.5	-2.9	-1.7
Hair/balding pattern: Pattern 2	2.4	3.0	5.7	-2.3	-1.2	-1.7	-1.5	2.4	-1.4	-0.5	-1.5	1.5	2.0	-1.8	-2.0
Had menopause	1.1	1.3	3.6	-1.0	-1.3	-1.3	-1.5	1.4	0.1	0.2	-0.7	1.9	1.1	-1.3	-0.1
Had other major operations	1.2	1.5	5.7	0.3	0.5	-2.0	-2.4	0.3	-0.2	-1.3	-1.1	1.8	0.8	-1.1	0.0
Forced vital capacity (FVC)	2.2	8.4	16.9	3.2	2.3	3.5	3.2	-2.6	4.1	2.5	3.0	-2.7	-2.4	2.2	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	12.1	3.5	0.6	1.2	1.0	-2.3	0.2	-1.2	0.8	-0.8	-1.6	0.8	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.8	-1.0	-1.3	-0.7	-0.7	0.7	-0.2	0.2	-1.4	0.7	0.7	-0.9	-1.7
Qualifications: None of the above	0.5	1.1	4.7	0.5	-1.3	-1.1	-1.4	1.0	-0.5	1.1	0.5	-0.4	0.2	-2.2	-0.1
Financial difficulties in last 2 years	3.3	4.4	9.0	-0.8	-2.1	-2.7	-3.0	2.7	-1.3	0.5	-1.2	2.3	2.2	-2.4	-2.3
Mouth/teeth dental problems	0.2	0.3	2.2	-0.8	0.2	0.0	0.2	-0.3	-0.1	0.5	-0.0	-1.5	-0.6	-0.6	-0.3
Heart attack	0.3	0.4	0.9	0.9	0.3	-0.6	-0.6	-0.9	0.5	-0.7	-0.5	-0.3	-0.6	0.6	0.4
Allergy	0.7	1.7	9.7	0.9	-1.0	0.1	-0.1	-1.2	1.3	0.1	1.0	-3.1	-2.1	-0.3	0.5
Pain all over the body in last month	0.3	0.3	0.6	-0.2	-0.7	-0.8	-0.6	-0.2	-0.3	0.4	-0.6	-0.4	-0.5	-0.8	-0.6
Diabetes (self-reported)	0.5	0.7	2.8	0.6	0.3	0.4	0.5	-0.8	0.8	1.1	0.7	-0.4	-0.9	0.8	1.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.8	-1.1	0.2	-0.2	-0.4	0.5	-0.3	-1.3	-0.1	2.0	1.2	0.2	-1.2
Medication: Ramipril	0.3	0.4	1.4	1.2	0.6	-0.3	-0.3	-0.7	1.1	-0.3	-0.1	-0.4	-0.5	0.2	-0.2
Medication: Simvastatin	0.9	1.4	3.9	-0.1	-0.6	-1.7	-2.0	1.0	-0.8	0.0	-0.4	1.7	1.1	-1.6	0.7
Fluid intelligence score	0.2	0.4	2.2	0.6	-0.5	0.4	0.3	-0.7	-0.0	0.6	-0.1	-0.5	-0.8	1.5	-0.0
Illnesses of siblings	0.9	1.3	5.6	-2.4	-0.5	-0.1	0.2	1.8	-0.7	0.0	-0.4	1.6	1.6	-0.2	-0.7
Neuroticism score	1.5	3.2	11.0	-0.3	-2.7	-2.3	-2.3	1.1	-1.1	1.8	-1.8	0.1	0.3	-3.3	-0.7
Weight	0.6	3.2	8.0	2.7	-0.8	1.6	1.9	-2.6	-0.2	0.4	1.1	-2.0	-2.8	0.0	1.9
Impedance of arm (right)	0.4	1.8	6.0	-1.4	-2.4	-1.3	-1.8	1.2	0.6	1.4	0.1	-1.1	0.0	-0.0	-1.8
Arm fat percentage (right)	1.0	3.8	12.2	2.9	-2.5	0.5	0.4	-2.7	-0.0	1.0	0.9	-3.0	-3.5	-0.2	0.7
Trunk fat-free mass	1.0	5.7	13.5	3.0	2.6	3.3	3.7	-3.2	0.9	-0.6	1.3	-1.1	-2.2	1.6	2.6
Hip circumference	0.2	1.0	3.0	1.0	-1.7	0.4	0.6	-0.9	-1.0	1.0	0.2	-1.3	-1.5	-0.5	0.7
Time employed in main current job	0.7	0.8	2.1	0.9	0.9	0.9	0.6	-1.0	0.9	1.3	1.4	-0.1	-0.7	0.3	0.8
Alcohol intake versus 10 years previously	1.8	2.7	4.6	1.2	2.1	1.9	2.1	-2.1	2.1	-0.9	1.5	-1.2	-1.7	1.3	0.9
Father’s age at death	1.1	1.4	6.7	-2.6	-0.1	-0.1	-0.1	1.6	-1.3	0.2	-0.8	1.6	1.7	-0.1	0.2
Worrier / anxious feelings	1.0	1.8	9.1	-0.3	-3.0	-1.3	-1.3	0.7	-0.1	0.7	-1.2	-0.2	0.0	-2.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	5.3	8.7	23.6	-1.4	-3.5	-4.0	-3.6	1.3	-4.1	0.6	-3.5	1.1	0.3	-4.9	-2.1
Falls in the last year	0.6	0.8	3.0	-0.6	-1.2	-0.7	-0.8	0.2	-1.2	-1.7	-0.9	-0.7	-0.0	0.2	-1.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.8	-0.6	-0.2	-0.2	-0.5	0.0	0.6	-0.9	-0.6	-0.4	0.1	-0.0
Number of live births	0.3	0.4	1.1	0.7	0.9	-0.8	-1.0	-0.4	-0.0	-0.4	-0.0	1.0	0.2	0.0	0.5
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	10.8	1.9	1.7	2.3	2.3	-1.7	3.3	3.1	2.2	-2.2	-1.7	1.5	1.4
Pulse rate	0.7	1.1	3.4	-0.5	0.3	-0.6	-0.8	1.8	0.5	1.7	-0.4	1.5	1.9	-0.0	0.2
Happiness	4.7	5.7	11.7	-2.3	-1.8	-3.4	-3.2	2.0	-2.5	-0.0	-2.9	1.4	1.7	-3.1	-2.3
Noisy workplace	0.5	0.6	3.4	-0.1	-0.6	-0.9	-1.0	0.7	-0.3	-0.4	-0.4	0.5	0.3	-1.9	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.0	-2.0	1.0	-0.1	-0.1	1.4	-0.4	0.7	-1.0	1.6	1.8	0.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	7.1	0.6	1.4	0.6	0.4	0.4	0.8	-0.3	1.0	2.7	1.3	0.7	1.3
Mouth/teeth dental problems: Dentures	0.2	0.3	1.4	0.8	-0.8	-0.1	-0.2	0.3	0.5	-1.2	0.3	0.6	0.3	-0.6	0.4
Asthma	0.4	0.8	2.7	1.4	1.3	0.9	0.9	-1.6	0.0	-0.6	0.4	0.3	-0.9	0.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.3	-1.8	0.1	-0.6	-0.8	1.8	-0.5	0.6	-0.2	1.1	1.5	0.7	-1.2
Medication: Cholesterol lowering	0.5	0.7	2.3	0.4	-1.1	-1.2	-1.4	-0.3	-0.4	0.2	0.0	0.2	-0.2	-1.5	1.0
Depression (self-reported)	0.6	0.7	3.3	0.1	0.1	-0.5	-0.8	0.8	-1.0	-1.8	-0.4	1.1	0.9	-0.3	-0.5
Medication: Lansoprazole	0.5	0.6	1.5	0.7	-0.9	-0.4	-0.2	-0.3	-1.0	-0.9	-1.0	0.1	-0.3	-0.9	-1.2
Prospective memory result	0.3	0.3	1.1	0.3	-0.3	0.6	0.8	-0.1	-0.3	-0.5	0.4	-1.1	-0.4	0.7	0.5
Lung cancer (father)	0.1	0.1	0.4	-0.1	0.5	0.4	0.5	-0.5	-0.4	-0.7	0.1	0.1	-0.1	0.5	-0.1
Illnesses of mother	0.8	0.9	3.9	-2.0	-0.4	0.4	0.8	1.2	-0.6	-0.5	-0.9	1.1	1.1	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	9.7	1.5	1.3	2.3	2.5	-1.8	3.1	2.2	1.6	-2.3	-1.9	1.3	0.4
Pulse wave Arterial Stiffness index	0.3	0.3	1.3	0.2	-0.7	-0.2	-0.2	1.1	-0.3	-0.1	0.1	0.5	1.0	-0.4	0.5
Impedance of arm (left)	0.6	2.8	7.8	-2.3	-2.8	-1.9	-2.5	2.1	-0.2	1.4	-0.3	-0.1	1.0	-0.7	-1.8
Arm fat mass (right)	0.9	3.6	11.2	2.9	-1.7	1.1	1.2	-2.8	0.1	0.8	1.1	-2.5	-3.4	-0.2	1.3
Trunk predicted mass	1.0	5.7	13.1	3.0	2.6	3.2	3.6	-3.2	1.0	-0.5	1.4	-1.1	-2.2	1.6	2.6
Standing height	0.1	1.0	3.4	0.1	0.6	1.8	1.9	-0.7	0.4	0.3	1.2	-0.4	-0.5	0.1	1.6
Length of working week for main job	0.7	0.8	3.1	0.4	1.1	0.2	0.6	-1.2	0.2	0.2	0.1	-1.8	-1.4	-0.8	-0.2
Exposure to tobacco smoke at home	0.7	0.8	2.0	0.8	-0.6	-1.3	-1.4	1.3	0.4	-0.4	-0.4	0.6	1.2	-0.8	-0.3
Breastfed as a baby	4.7	5.9	11.7	3.4	1.9	3.0	2.4	-2.3	2.5	1.5	3.1	-2.0	-1.9	2.7	1.4
Tense / ‘highly strung’	1.0	1.6	7.3	-0.2	-2.7	-1.3	-1.2	0.1	-0.7	0.5	-1.4	-1.3	-0.7	-1.6	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.9	0.1	-0.8	-0.8	-1.0	0.5	-0.6	-1.6	-0.6	1.7	1.1	-1.2	-0.1
Hair/balding pattern: Pattern 4	1.4	3.3	12.8	2.0	-1.4	0.7	0.3	-0.4	1.9	2.4	2.4	-3.6	-1.8	0.0	1.4
Birth weight of first child	0.6	1.1	3.4	-0.4	-0.4	-1.3	-1.5	1.8	-0.2	0.9	-0.0	1.1	1.4	-0.6	1.2
Peak expiratory flow (PEF)	0.8	1.9	6.6	1.6	0.3	1.2	1.1	-1.1	1.5	2.6	1.5	-1.3	-1.1	1.0	1.3
Pulse wave reflection index	0.8	1.0	3.8	-1.1	-0.2	-0.4	-0.1	1.9	-0.6	-1.5	-0.5	0.9	1.8	-0.1	0.3
Ever highly irritable/argumentative for 2 days	2.6	3.1	9.8	-0.9	-0.7	-3.1	-3.1	1.3	-1.9	-0.7	-2.2	0.8	1.2	-1.5	-1.6
Loud music exposure frequency	1.5	1.7	4.0	-0.6	-2.0	-1.4	-1.3	1.6	-0.6	-0.5	-1.1	0.8	1.3	-1.7	-1.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.7	-1.7	0.0	-1.2	-1.4	0.8	-1.9	0.9	-1.2	1.5	1.2	-0.2	-0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.3	0.7	1.0	1.2	-0.9	0.7	0.9	-0.3	-0.1	-0.8	0.6	1.2
Blood clot in the leg (DVT)	0.4	0.6	2.5	0.1	1.3	0.8	0.9	-0.2	0.6	0.4	-0.3	1.6	0.5	0.4	0.4
Medication: Paracetamol	0.9	1.5	6.5	-0.6	-0.4	-0.8	-1.1	1.9	-0.2	0.5	0.2	2.5	2.1	0.4	-0.7
Headache pain in last month	0.7	1.3	3.9	0.1	0.6	-0.0	-0.5	2.0	0.9	1.6	1.3	1.4	1.9	-0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.2	3.7	-0.3	1.9	1.7	1.8	0.3	0.4	1.3	0.7	0.7	0.5	1.4	-0.2
Glaucoma (self-reported)	2.0	2.4	5.0	-2.2	-1.7	-1.2	-1.1	2.0	-0.8	-0.6	-0.9	1.1	1.8	-2.2	-1.6
Gout (self-reported)	1.9	2.6	5.0	2.2	0.8	1.4	1.2	-1.8	1.5	1.4	1.4	-2.0	-1.9	1.7	1.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	-0.9	-0.2	0.0	0.2	1.1	-0.6	0.1	-0.4	1.1	1.1	-0.5	-1.3
Medication: Amlodipine	0.6	0.8	2.6	0.9	-0.6	0.2	0.2	-1.2	-0.5	0.2	0.1	-1.2	-1.6	-1.4	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.5	1.1	0.7	0.1	0.5	-1.6	0.2	-0.1	-0.4	-1.1	-1.4	-0.3	-0.7
Birth weight	1.2	2.6	6.5	1.5	-1.4	1.4	1.1	-0.9	1.2	1.8	2.1	-2.5	-1.9	1.3	1.6
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.9	-1.2	-1.3	-2.1	-2.2	0.9	-2.0	-0.1	-1.3	1.2	0.9	-1.9	-1.0
High blood pressure (siblings)	1.1	1.6	5.1	2.3	0.3	0.5	0.2	-1.7	0.7	0.8	0.8	-1.5	-1.8	-0.6	1.8
Forced vital capacity (FVC), Best measure	1.7	6.1	13.8	2.5	1.8	3.1	3.2	-2.6	3.7	1.8	2.1	-2.6	-2.5	1.6	1.0
Body fat percentage	0.6	2.3	13.1	1.1	-3.6	-1.3	-1.5	-0.2	-1.2	1.2	0.4	-1.1	-1.2	-1.9	0.5
Leg fat percentage (right)	1.0	3.5	10.4	1.1	-3.2	-2.3	-2.6	1.2	-2.1	1.8	0.1	0.7	0.4	-2.7	1.1
Arm fat-free mass (right)	0.4	2.2	7.2	1.4	1.5	2.1	2.7	-1.8	-0.0	-0.8	0.5	-0.3	-1.1	0.2	2.2
Exposure to tobacco smoke outside home	1.1	1.5	5.2	0.0	-1.1	-1.7	-1.7	2.3	-0.7	0.7	-0.3	0.2	1.4	-1.5	0.2
Comparative body size at age 10	3.8	10.5	30.6	4.0	-1.2	2.5	2.6	-4.9	1.5	1.6	1.5	-5.3	-5.5	2.2	1.3
Number of full brothers	1.3	1.7	5.4	0.4	-0.1	-1.2	-1.6	1.9	0.3	2.3	1.1	1.0	1.7	-1.2	0.2
Worry too long after embarrassment	5.9	9.9	31.2	-1.9	-4.6	-3.8	-3.4	2.0	-2.9	-0.9	-3.7	0.1	0.8	-5.6	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.0	-0.2	-1.4	0.7	0.7	-0.8	-0.5	-0.6	0.1	-1.1	-0.8	-0.7	-0.0
Wheeze or whistling in the chest in last year	0.6	1.1	2.6	1.4	1.6	1.4	1.6	-0.3	0.5	1.1	0.4	1.0	0.5	1.1	0.9
Number of children fathered	1.6	1.8	3.4	1.7	1.4	1.3	1.5	-1.6	1.0	1.1	1.0	-1.2	-1.4	0.8	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.1	0.4	-0.3	-0.5	-0.7	0.7	0.7	1.1	0.2	-0.1	0.5	1.4	-1.3
Age at first live birth	1.6	2.9	7.0	-0.2	1.2	2.4	2.6	-2.3	1.7	-0.7	0.1	-2.1	-1.9	1.9	-0.2
Pulse wave peak to peak time	0.2	0.2	0.9	-0.4	0.7	0.2	0.2	-1.0	0.2	-0.0	-0.1	-0.1	-0.8	0.1	-0.5
Health satisfaction	1.1	1.4	4.0	0.4	-0.9	-1.7	-1.4	-0.5	-0.8	-0.8	-2.0	-0.9	-0.7	-1.8	-1.0
Shortness of breath walking on level ground	1.0	1.2	3.2	-0.1	-0.8	-1.6	-1.5	0.0	-1.8	-1.5	-1.2	-0.1	0.1	-0.9	-0.8
Qualifications: College or University degree	1.1	3.4	14.2	-1.2	1.9	3.2	3.8	-1.1	1.9	-0.2	0.7	-0.6	-0.8	2.2	0.4
Eye problems/disorders: None of the above	1.2	1.4	5.5	2.4	0.1	1.0	0.5	-1.0	1.2	1.0	1.5	-0.7	-1.1	1.3	1.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	0.2	-1.2	-0.4	-0.2	0.2	-1.0	-1.1	-0.7	0.6	0.2	-0.2	0.1
Emphysema/chronic bronchitis	1.1	1.2	3.9	-0.6	-2.0	-1.2	-1.2	0.0	-1.4	0.2	-0.9	0.4	-0.2	-1.3	-1.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.6	-0.0	-0.3	0.4	0.7	-1.5	-0.8	-0.4	-0.5	-1.6	-1.6	-0.8	0.6
Neck or shoulder pain in last month	1.4	2.0	6.6	1.4	0.9	-0.5	-0.9	1.4	1.1	2.6	1.1	2.4	1.7	-0.4	0.9
Medication: Blood pressure	0.4	0.7	2.2	0.1	-1.5	-0.9	-0.7	-0.7	-0.2	-0.8	-1.0	-1.4	-1.0	-0.7	0.1
Angina (self-reported)	2.0	2.6	7.6	2.8	0.8	1.1	1.0	-1.9	1.6	2.2	1.4	-1.1	-1.7	1.1	1.8
Migraine (self-reported)	1.6	1.9	5.6	-0.6	-0.9	-1.8	-2.0	2.4	-0.7	0.8	-0.6	1.2	1.8	-1.7	-0.2
Medication: Ibuprofen	1.0	1.2	3.9	-2.0	0.3	-0.8	-0.8	1.8	-0.8	0.4	-0.8	1.3	1.5	0.2	-0.9
Medication: Allopurinol	0.3	0.4	2.1	1.0	0.4	0.0	-0.0	-0.9	0.3	-0.3	0.1	-1.4	-1.0	0.3	-0.1
Medication: Omeprazole	1.1	1.3	5.7	0.2	0.2	-0.8	-0.9	1.6	-0.8	1.0	0.6	2.4	1.9	-0.8	-0.6
Medication: Seretide 50 evohaler	0.9	1.0	4.0	1.2	0.4	0.2	-0.2	0.5	0.3	1.4	0.8	1.7	0.7	-0.4	2.0
Mean time to correctly identify matches	0.3	0.6	1.4	-0.7	-0.5	0.9	1.0	-1.1	1.2	-1.0	0.3	-0.1	-1.1	0.5	-0.2
Heart disease (mother)	0.9	1.0	6.5	2.6	0.2	-0.5	-1.0	-0.4	0.0	0.4	1.6	-0.7	-0.3	0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.5	1.3	-0.8	1.1	0.5	-0.3	0.7	1.1	1.6	0.0	-0.1	0.6	1.2
Whole body fat mass	0.5	2.0	6.8	1.8	-2.6	-0.0	0.0	-1.4	-0.7	0.9	0.7	-1.6	-2.1	-1.2	1.1
Leg fat mass (right)	0.4	1.6	6.0	1.7	-2.5	-0.8	-0.8	-0.5	-1.3	0.8	0.4	-0.4	-1.1	-1.7	1.3
Arm predicted mass (right)	0.5	2.3	7.5	1.6	1.4	2.2	2.7	-1.9	-0.1	-0.5	0.8	-0.4	-1.2	0.3	2.2
Pulse rate, automated reading	0.9	2.9	5.9	-0.7	-2.4	-2.0	-2.1	2.0	-1.3	0.8	-1.4	1.8	1.7	-2.4	0.1
Alcohol intake frequency.	1.1	2.7	8.6	-1.5	-1.9	-1.8	-2.1	1.8	-0.8	-0.3	-0.1	1.0	1.3	-2.9	-1.7
Comparative height size at age 10	0.9	5.1	13.3	2.1	1.2	3.6	3.6	-2.1	2.6	0.0	2.4	-1.1	-1.6	1.4	2.6
Number of full sisters	2.2	2.6	6.5	-0.5	-0.5	-2.5	-2.4	1.9	-0.8	-0.2	-1.3	1.4	2.0	-2.6	-0.7
Suffer from ‘nerves’	1.7	2.7	7.3	2.7	-1.1	0.9	0.3	-0.6	2.4	2.6	1.8	-1.9	-1.2	1.2	0.5
Overall health rating	3.5	7.5	22.1	-0.5	-3.6	-4.1	-3.8	1.4	-2.7	0.2	-3.0	0.8	0.6	-4.7	-2.0
Chest pain or discomfort	0.2	0.3	1.4	1.0	0.3	0.2	0.4	-0.5	0.1	0.0	0.1	1.0	0.0	0.3	-1.2
Had major operations	1.3	1.5	4.8	1.3	-1.2	0.7	1.0	-2.1	0.7	-0.6	0.2	-1.5	-2.2	0.8	-0.1
Age at last live birth	0.8	1.2	2.7	-0.7	1.6	1.4	1.6	-1.3	1.0	-0.4	-0.0	-1.0	-1.0	1.0	-0.1
Family relationship satisfaction	4.1	5.1	10.9	-3.2	-2.2	-2.8	-2.4	1.1	-2.1	-1.1	-3.3	0.9	0.9	-2.7	-2.3
Leg pain on walking	1.0	1.3	3.6	1.2	1.0	0.0	-0.2	-1.0	0.9	1.4	1.1	-1.9	-1.4	0.5	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.8	-0.2	-0.0	-1.4	-1.7	0.6	0.2	0.1	-0.4	-0.2	0.5	-0.8	-0.6
Commuting to job workplace: Car/motor vehicle	1.3	1.4	5.0	2.2	-0.3	0.2	-0.2	-1.3	-0.0	-0.6	1.8	-1.4	-1.7	1.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.6	-0.1	-0.8	0.7	1.2	-1.3	-0.2	0.2	-0.8	-2.1	-1.6	0.2	-0.4
Medication: Aspirin	2.8	3.7	8.3	2.3	1.6	1.8	1.7	-2.1	2.9	0.4	1.6	-2.4	-2.1	1.8	1.4
Supplements: Vitamin C	0.4	0.5	1.5	-0.6	1.1	1.0	1.2	-1.0	0.0	-0.4	0.4	-0.1	-0.6	0.5	-0.0
Knee pain experienced in last month	1.7	2.6	5.4	2.3	0.9	1.3	1.1	-1.5	1.2	2.3	1.6	-1.7	-1.8	1.7	1.2
Hypertension (Self-reported)	0.6	1.7	5.5	2.0	-1.4	-0.5	-0.6	-1.4	0.5	-0.1	-0.0	-2.3	-2.0	-1.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.8	-0.1	-0.6	-0.9	-0.9	1.0	-0.1	-0.4	-0.2	1.1	0.8	-1.7	-1.4
Illnesses of father: Heart disease	1.1	1.5	5.4	0.1	0.5	1.1	1.5	-2.3	1.1	-1.7	-0.9	-0.5	-1.8	0.3	-0.9
Illnesses of siblings: Diabetes	0.6	0.8	2.2	-1.0	-0.4	-1.0	-0.5	0.8	-1.5	-0.1	-1.4	0.1	0.6	-1.1	-0.7
Smoking status: Previous	0.4	0.6	2.1	1.1	1.5	0.5	0.4	-1.2	0.5	0.4	0.5	1.0	-0.3	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.7	0.4	1.3	0.7	0.3	0.7	0.7	2.4	1.7	0.7	0.9	-0.0	1.4
Whole body fat-free mass	1.2	6.6	16.2	3.0	2.2	3.6	4.0	-3.5	1.1	-0.5	1.6	-1.7	-2.8	1.8	2.6
Leg fat-free mass (right)	1.5	8.1	20.1	2.9	1.6	3.9	4.5	-4.0	1.4	-0.5	1.7	-2.8	-3.7	2.0	2.0
Arm fat percentage (left)	0.7	2.9	9.4	2.4	-2.6	0.2	0.1	-2.3	-0.3	0.8	0.8	-2.5	-3.1	-0.5	0.6
Average weekly red wine intake	3.0	4.5	11.5	2.1	2.1	2.7	2.9	-1.5	2.7	0.5	1.6	-1.1	-1.0	3.4	1.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.4	0.4	0.9	0.6	0.2	-0.1	1.2	0.2	0.9	0.4	0.2	1.1	-0.2
Mood swings	0.9	1.5	4.9	0.1	-1.9	-1.3	-1.3	0.3	-1.0	1.9	-0.9	0.0	-0.4	-2.2	-1.0
Loneliness, isolation	0.4	0.5	3.8	0.3	-0.9	-0.2	-0.2	0.7	0.1	1.9	0.1	-0.2	0.2	-0.6	0.6
Long-standing illness, disability or infirmity	0.3	0.4	2.2	0.5	-0.8	-0.8	-0.6	-0.4	-1.5	-0.0	-0.7	-0.0	-0.6	-0.3	0.3
Ever had bowel cancer screening	1.4	1.7	4.5	0.9	-1.3	-0.2	-0.2	-2.1	-0.8	-1.8	-0.8	-1.5	-2.1	-0.3	-1.2
Diabetes diagnosed by doctor	0.1	0.2	1.1	0.1	0.2	-0.3	-0.2	0.1	0.4	0.8	0.3	0.6	0.2	0.5	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.2	1.0	0.8	-0.1	-0.3	-0.3	1.1	-0.7	0.5	0.4	0.2	-0.1	-0.5
Friendships satisfaction	1.9	2.4	6.4	-1.3	-1.0	-2.5	-2.3	0.8	-0.8	0.5	-2.2	0.2	0.6	-2.2	-1.6
Qualifications: nursing, teaching	0.9	1.4	5.1	-1.6	-0.6	-0.3	-0.1	1.9	-0.5	0.0	-1.0	1.6	2.3	1.1	-0.7
Commuting to job workplace: Walk	4.0	4.3	10.8	-2.8	-1.5	-2.1	-2.0	3.3	-1.7	0.1	-2.0	1.8	2.6	-2.1	-1.0
Eye problems/disorders: Cataract	0.4	0.5	1.4	-1.1	0.7	-1.0	-0.7	0.2	-0.1	-0.8	-1.2	0.2	0.3	-0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	7.8	0.7	-0.4	-0.5	-0.6	2.4	-0.0	0.5	0.1	2.5	2.8	0.6	-0.7
Medication for cholesterol	0.6	0.9	1.9	-1.4	0.4	0.9	1.3	1.1	-0.5	0.7	-0.3	0.8	1.3	1.1	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	4.0	2.0	0.9	0.1	-0.4	-0.9	0.8	1.1	0.9	-0.1	-0.6	0.6	1.9
Back pain experienced in last month	0.9	1.3	6.3	0.7	1.2	-0.4	-0.7	1.2	-0.4	0.6	1.0	2.5	1.6	-0.5	0.7
Mineral and other dietary supplements	0.4	0.5	4.3	0.1	-0.1	-0.3	-0.2	-0.2	0.1	-2.1	-1.0	0.1	0.0	0.3	-0.7
Breast cancer (self-reported)	0.2	0.3	0.8	0.1	-0.5	-0.7	-0.9	-0.6	-0.2	-0.3	-0.1	-0.4	-0.9	-0.4	-0.0
Asthma (self-reported)	0.4	0.9	2.1	1.3	1.4	1.1	1.0	-1.4	0.2	-0.4	0.7	0.7	-0.6	1.0	-0.3
Osteoporosis (self-reported)	0.2	0.3	2.0	-0.1	0.3	0.1	0.4	0.1	0.5	1.4	0.3	-0.1	-0.1	-0.8	0.1
Osteoarthritis (self-reported)	0.6	0.7	2.2	-0.0	1.5	-1.0	-1.0	-1.0	-1.1	0.2	-1.3	0.7	-0.5	-0.2	0.2
Medication: Aspirin	3.0	4.0	7.9	2.2	1.3	2.0	2.1	-2.6	2.8	-0.1	1.3	-2.5	-2.6	1.6	1.0
Medication: Gliclazide	2.2	2.5	5.0	2.2	1.1	1.1	0.9	-1.2	1.0	1.6	2.1	-2.0	-1.7	-0.0	2.2
Illnesses of father: None of the above (group 1)	0.5	0.6	2.7	0.0	-0.4	-1.3	-1.6	0.8	-1.1	-0.0	0.1	0.1	0.6	0.2	-0.3
Smoking status: Current	2.8	4.5	14.5	-1.4	0.4	-2.1	-2.4	3.0	-2.2	0.1	-0.9	3.8	3.3	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	8.9	1.8	-0.1	1.3	1.8	-2.1	2.4	0.7	0.0	-3.0	-2.6	0.0	-0.9
Whole body water mass	1.1	6.5	16.1	3.0	2.2	3.6	4.0	-3.5	1.1	-0.4	1.6	-1.8	-2.8	1.6	2.6
Leg predicted mass (right)	1.6	8.3	20.2	3.1	1.6	4.0	4.5	-4.0	1.5	-0.5	1.7	-2.9	-3.7	2.1	2.0
Arm fat mass (left)	0.7	2.8	8.7	2.7	-1.6	0.9	1.0	-2.5	-0.1	0.8	1.0	-2.0	-3.0	-0.3	1.3
Number of self-reported non-cancer illnesses	0.7	1.2	2.6	0.9	-0.7	-1.4	-1.4	-0.3	-0.6	-1.4	-1.0	1.6	0.2	-1.1	-1.4
Average weekly champagne plus white wine intake	0.7	1.0	2.7	1.3	0.9	1.0	0.9	-1.7	0.7	-0.2	0.4	-0.9	-1.4	0.9	0.1
Miserableness	1.1	1.9	7.8	1.1	-1.2	-1.4	-1.2	1.0	-1.0	2.8	-0.6	0.5	0.5	-2.4	-0.9
Guilty feelings	2.7	4.1	9.8	-1.1	-2.6	-2.8	-2.3	0.4	-2.2	-0.8	-2.9	0.2	-0.1	-3.1	-1.8
Wears glasses or contact lenses	0.5	0.6	3.0	-0.4	-1.1	-0.8	-0.4	0.1	-0.1	-1.0	-1.0	0.1	-0.0	-1.7	-0.2
Ever taken oral contraceptive pill	0.2	0.2	0.8	-0.1	-0.5	-0.2	-0.3	0.1	0.9	0.2	0.1	0.4	0.0	0.6	-0.8
Hearing aid user	0.7	0.8	3.5	0.5	-1.4	0.4	0.7	-0.3	-1.0	-0.1	0.2	-1.0	-0.8	-1.9	0.4
Mother’s age at death	0.2	0.3	0.9	-0.6	-0.7	0.6	0.5	0.1	0.5	-0.9	0.7	0.5	-0.0	0.4	0.1
Financial situation satisfaction	1.2	1.5	3.6	-1.1	0.2	-1.7	-1.4	0.8	-0.9	0.2	-1.9	0.7	0.9	-1.5	-1.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	0.9	0.1	0.4	0.6	0.8	0.4	1.1	0.1	0.8	0.9	0.0	1.3
Commuting to job workplace: Public transport	1.4	1.7	5.1	-2.1	-0.4	-1.3	-0.9	0.6	-1.5	0.2	-2.3	0.6	0.7	-2.1	-0.6
Eye problems/disorders: Glaucoma	0.7	0.9	2.5	-1.1	-0.4	-0.6	-0.5	1.5	-0.4	-0.3	-0.4	1.0	1.6	-0.8	-1.3
Medication: Blood pressure	0.5	1.0	2.4	0.8	0.3	-0.0	0.3	-1.4	0.7	-1.5	-0.8	-0.3	-1.4	-1.2	-1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.5	-1.1	-0.3	-1.2	-1.2	0.4	-0.3	-0.3	-0.7	1.2	0.4	-0.9	-1.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	0.1	0.0	-0.3	-0.3	0.9	0.3	0.9	0.5	0.6	0.7	-0.6	0.0
High cholesterol (Self-reported)	0.4	0.7	2.3	-0.5	-1.0	-0.9	-1.2	0.8	0.3	0.0	0.1	1.5	0.9	-0.9	0.5
Medication: Bendroflumethiazide	0.3	0.5	1.3	1.1	0.7	0.0	-0.6	-0.5	1.0	-0.1	1.1	-0.2	-0.6	0.2	0.9
Medication: Paracetamol	0.5	0.8	4.7	-0.4	-0.8	-0.5	-0.7	1.0	0.1	0.8	0.1	2.2	1.3	0.1	-0.1
Medication: Lisinopril	0.8	1.0	3.9	-0.9	-1.3	-0.3	-0.0	0.5	-0.4	-1.5	-0.9	0.2	0.2	-2.0	-1.3
Medication: Atorvastatin	0.7	0.9	5.3	-0.9	-2.3	-0.8	-0.8	0.3	-1.0	-0.7	-0.2	-0.1	-0.2	-1.2	-0.3
Illnesses of father: High blood pressure	0.9	1.1	2.9	-0.2	-1.1	-0.1	0.4	-1.3	-0.2	-0.1	-1.3	-1.4	-1.7	-1.7	-0.8
Alcohol drinker status: Never	0.4	0.5	3.1	-0.2	-0.7	-0.1	-0.3	-0.3	-0.2	0.7	0.9	-1.7	-0.9	0.0	-0.2
Ever smoked	0.6	1.0	5.2	0.5	1.7	-0.4	-0.7	0.4	-0.4	-0.1	0.0	2.3	1.4	-0.3	0.7
Basal metabolic rate	1.0	5.5	12.4	3.0	1.5	3.1	3.5	-3.2	0.8	-0.1	1.6	-1.8	-2.8	1.3	2.5
Leg fat percentage (left)	1.0	3.5	9.7	0.9	-3.1	-2.4	-2.6	1.3	-2.2	1.6	-0.2	0.6	0.4	-2.9	0.9
Arm fat-free mass (left)	0.7	3.4	8.1	2.5	1.6	2.5	2.8	-2.4	0.4	0.0	1.2	-0.8	-1.7	0.9	2.5
Number of operations (self-reported)	0.5	0.8	4.3	2.1	-0.3	-0.0	-0.3	-1.2	0.6	-0.8	0.2	0.4	-0.9	0.4	1.3
Average weekly beer plus cider intake	0.3	0.5	1.4	0.2	-0.2	-1.0	-1.2	0.1	-0.8	0.8	0.2	-0.7	-0.2	-1.1	-0.2
Irritability	0.8	1.4	5.1	-0.6	0.1	-2.0	-2.3	0.5	-1.7	1.2	-1.0	0.6	0.5	-1.2	0.1
Risk taking	0.6	0.9	3.2	-0.7	1.3	-0.3	-0.4	1.4	0.8	0.3	0.3	1.0	1.8	1.1	-0.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	7.4	0.7	-0.7	-0.1	0.2	-1.0	0.1	-2.7	-1.0	-0.4	-0.7	-0.0	-0.4
Fractured/broken bones in last 5 years	0.2	0.2	1.2	-0.2	1.1	0.2	0.2	-0.1	0.6	0.4	-0.2	0.6	0.3	0.8	0.1
Age started oral contraceptive pill	1.2	1.5	5.6	-2.4	-2.1	-0.7	-0.7	1.2	-1.1	-0.1	-1.1	0.5	0.5	-1.5	0.2
Diastolic blood pressure, automated reading	2.7	8.3	16.5	4.1	-1.2	2.4	2.0	-2.7	3.5	3.5	3.2	-3.7	-3.5	0.8	1.8
Ever depressed for a whole week	1.0	1.2	3.1	-0.4	-0.6	-1.4	-1.4	1.1	-0.2	-0.8	-1.1	1.8	1.4	-1.1	-0.8
Unable to work because of sickness or disability	0.7	0.9	2.9	-0.3	-1.2	-1.4	-1.7	1.0	-0.8	-0.8	-0.5	0.7	0.9	-0.7	0.7
Commuting to job workplace: Cycle	2.1	2.6	8.2	0.4	2.7	2.5	2.9	-0.3	1.0	-0.6	1.2	0.8	0.5	2.3	-0.2
Myopia	1.2	1.7	5.6	-1.1	-2.2	-1.3	-1.0	-0.3	-2.4	-0.8	-1.5	-0.2	-0.5	-1.8	0.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	7.1	-2.7	0.5	0.1	0.2	2.0	-1.4	0.3	-0.5	2.3	2.4	0.6	-0.8
Cholesterol lowering medication	0.3	0.4	1.1	0.2	-0.4	-0.8	-1.1	0.2	0.6	-0.6	0.2	1.0	0.4	-0.8	0.7
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	9.2	-0.3	-0.8	-1.7	-1.8	2.5	-1.6	1.1	-0.4	3.0	2.7	-1.4	-0.8
Pain experienced in last month	0.7	1.1	4.5	-0.7	-1.2	0.6	0.7	-1.0	-0.2	-2.0	-0.3	-2.1	-1.1	0.3	-0.2
Supplements: Calcium	0.8	0.9	2.8	-1.6	-0.1	0.9	0.9	-1.2	0.5	1.7	0.4	-0.4	-1.1	0.3	0.3
Basal cell carcinoma (self-reported)	1.2	1.4	4.6	-1.2	-0.4	-0.8	-1.0	1.8	-0.1	0.0	-0.4	2.0	2.1	-1.0	-0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.7	-0.1	-0.6	-0.5	-0.7	0.3	-0.6	-0.6	-0.3	-0.4	0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.9	-0.0	1.4	0.5	0.7	-0.4	0.2	0.4	-0.5	1.2	0.3	0.3	0.2
Heart disease (siblings)	1.1	1.4	5.3	1.0	0.4	1.0	1.4	-1.2	1.3	-2.3	-0.2	-0.8	-0.8	1.2	-1.2
Alcohol drinker status: Previous	1.0	1.2	4.9	-0.8	-1.5	-0.8	-0.5	0.2	-0.5	-0.8	-0.8	0.1	0.1	-2.2	-1.9
Pack years of smoking	1.3	1.9	5.2	-1.1	-2.3	-1.9	-2.2	1.6	-1.5	-0.2	-0.4	0.5	1.0	-1.5	0.1
Impedance of whole body	2.0	10.2	22.2	-4.0	-3.3	-4.0	-4.7	4.7	-1.5	1.4	-1.1	2.3	3.6	-2.7	-2.0
Leg fat mass (left)	0.4	1.5	5.7	1.7	-2.4	-0.8	-0.8	-0.4	-1.3	0.7	0.4	-0.5	-1.0	-1.8	1.2
Arm predicted mass (left)	0.6	3.2	8.0	2.3	1.8	2.4	2.8	-2.2	0.4	0.1	1.2	-0.7	-1.5	0.9	2.5