Best TWAS P=3e-29 · Best GWAS P=4.98e-29 conditioned to 0
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CD46 | 0.14 | 0.16 | bslmm | 499 | 0.16 | 3.4e-19 | -11.0 | 10.8 | 4.0e-27 | -0.87 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CD46 | 0.07 | 0.05 | lasso | 3 | 0.03 | 7.9e-04 | -10.9 | 10.4 | 2.7e-25 | -0.83 | 0.03 | 0.97 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | CD46 | 0.11 | 0.02 | lasso | 2 | 0.03 | 1.0e-02 | -10.9 | 11.2 | 3.3e-29 | -0.81 | 0.03 | 0.86 | TRUE |
| 4 | GTEx | Artery Aorta | CD46 | 0.20 | 0.18 | enet | 11 | 0.20 | 2.5e-11 | -10.8 | 10.5 | 8.0e-26 | -0.84 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Artery Tibial | CD46 | 0.27 | 0.35 | lasso | 4 | 0.34 | 9.0e-28 | -10.8 | 10.8 | 2.4e-27 | -0.88 | 0.05 | 0.95 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | CD46 | 0.33 | 0.25 | lasso | 4 | 0.24 | 3.2e-08 | -10.9 | 11.2 | 3.0e-29 | -0.86 | 0.02 | 0.98 | TRUE |
| 7 | GTEx | Colon Sigmoid | CD46 | 0.29 | 0.23 | lasso | 2 | 0.21 | 7.6e-08 | -10.9 | 11.0 | 5.5e-28 | -0.88 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | CD46 | 0.29 | 0.24 | lasso | 4 | 0.22 | 2.1e-08 | -10.9 | 10.6 | 4.5e-26 | -0.85 | 0.02 | 0.98 | FALSE |
| 9 | GTEx | Esophagus Muscularis | CD46 | 0.37 | 0.27 | lasso | 12 | 0.28 | 1.5e-17 | -11.0 | 11.1 | 9.8e-29 | -0.93 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | CD46 | 0.12 | 0.10 | enet | 6 | 0.10 | 1.9e-05 | -10.9 | 10.9 | 8.0e-28 | -0.88 | 0.03 | 0.95 | FALSE |
| 11 | GTEx | Nerve Tibial | CD46 | 0.24 | 0.15 | lasso | 6 | 0.20 | 2.1e-14 | -5.9 | 8.8 | 9.4e-19 | -0.73 | 0.69 | 0.31 | FALSE |
| 12 | GTEx | Nerve Tibial | PFKFB2 | 0.08 | 0.00 | lasso | 4 | 0.00 | 8.8e-01 | -6.3 | -6.2 | 4.0e-10 | -0.02 | 0.02 | 0.72 | TRUE |
| 13 | GTEx | Ovary | CD46 | 0.21 | 0.08 | enet | 11 | 0.12 | 7.0e-04 | -5.9 | 8.5 | 2.7e-17 | -0.63 | 0.07 | 0.64 | TRUE |
| 14 | METSIM | Adipose | CD55 | 0.07 | 0.05 | blup | 366 | 0.06 | 1.7e-09 | 2.1 | 5.7 | 1.4e-08 | -0.04 | 1.00 | 0.00 | TRUE |
| 15 | METSIM | Adipose | EIF2D | 0.13 | 0.07 | bslmm | 353 | 0.09 | 3.8e-13 | -3.5 | -5.3 | 1.0e-07 | 0.03 | 1.00 | 0.00 | TRUE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PFKFB2 | 0.06 | 0.01 | blup | 57 | 0.04 | 5.1e-05 | 4.4 | -5.4 | 7.7e-08 | -0.09 | 0.03 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CD46 | 0.10 | 0.12 | lasso | 4 | 0.12 | 5.6e-14 | -11.0 | 11.0 | 2.2e-28 | -0.88 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CR1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 6.4e-07 | -5.3 | -5.3 | 1.1e-07 | 0.16 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C4BPA | 0.11 | 0.00 | blup | 49 | 0.05 | 3.2e-03 | 1.7 | -5.2 | 2.2e-07 | 0.04 | 0.01 | 0.38 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | CD46 | 0.03 | 0.03 | enet | 3 | 0.03 | 6.9e-04 | -6.0 | -5.7 | 1.0e-08 | 0.44 | 0.17 | 0.12 | TRUE |