Hub : Genes

PFKFB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Left Ventricle 0.1206 0.0512 3.9e-03 0.026 NA 0.005 NA -0.005 0.01500 NA 0.17000 NA 0.9300
2 GTEx Nerve Tibial 0.0815 0.0362 9.3e-03 -0.003 NA -0.004 NA -0.004 0.63000 NA 0.98000 NA 0.8800
3 YFS Blood 0.0186 0.0096 2.4e-02 0.011 0.002 0.005 0.007 0.007 0.00013 8.9e-02 0.00520 0.0015 0.0017
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0568 0.0265 1.4e-05 0.011 0.037 0.025 NA 0.019 0.02000 5.1e-05 0.00072 NA 0.0031

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.0 1.6 5.1 -0.6 2.3 -0.4 0.9
Bipolar Disorder or Schizophrenia 1.8 4.3 12.5 -1.0 3.5 -0.8 1.8
Depressed Affect (Nagel 2018) 0.3 0.7 1.1 1.1 -0.7 -0.2 -1.0
Depression (Nagel 2018) 1.8 2.7 5.5 -1.1 -2.3 0.8 -1.9
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.9 0.6 -0.3 -0.4 -1.0
Neuroticism (Nagel 2018) 0.6 1.5 2.6 1.4 -1.1 -0.3 -1.6
Schizophrenia (2018) 1.2 2.5 6.4 -0.8 2.5 -0.7 1.5
Schizophrenia vs Biploar Disorder 0.3 0.4 1.2 -0.2 0.6 -1.1 0.3
Worry (Nagel 2018) 1.1 2.3 3.9 1.3 -2.0 0.3 -1.8
Alzheimer’s Disease (in mother) 0.8 1.0 1.5 -0.1 1.2 -0.9 1.2
Alzheimer’s Disease (in father) 2.2 2.4 5.0 -1.2 -1.7 -0.5 -2.2
Alzheimer’s Disease (including proxy) 0.5 0.7 1.4 -1.2 0.7 -1.0 0.2
Crohns Disease (2017) 0.3 0.6 1.1 0.6 -0.0 0.9 1.0
Irritable Bowel Disease (IBD) 0.6 1.4 2.9 0.0 0.7 1.5 1.7
Ulcerative Colitis (UC) 1.3 2.5 4.2 -0.7 1.3 1.9 2.0
Major Depression (MDD) 0.3 0.4 1.0 0.4 1.0 -0.2 0.5
Reaction Time 2.9 5.6 10.1 2.7 1.9 1.4 3.2
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.0 1.7 -0.5 -0.1 -1.3
Breast Cancer 0.3 0.8 2.3 -1.5 0.1 0.7 0.6
Ovarian Cancer 0.5 0.7 1.4 1.0 -0.6 1.2 0.2
Prostate Cancer 1.4 1.9 4.4 -1.0 2.1 -1.4 0.5
Age at First Birth 0.7 1.0 1.3 1.1 -1.1 -0.5 -1.1
Bipolar Disorder (2011) 0.1 0.1 0.2 0.1 0.4 -0.4 -0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 -0.4 0.0 0.9 0.5
Coronary Artery Disease (CAD) 0.2 0.2 0.5 -0.6 0.4 0.1 -0.7
Crohns Disease (2012) 0.6 0.9 2.4 0.6 0.4 0.8 1.5
Mean Putamen Volume 1.0 1.1 2.0 -1.1 1.2 0.1 1.4
Fasting Glucose 1.4 1.7 3.7 0.1 1.9 -1.0 1.4
HbA1C 0.3 0.4 0.7 0.1 0.7 -0.8 0.5
HDL Cholesterol 0.5 0.9 1.6 -1.3 0.3 1.2 0.7
LDL Cholesterol 0.6 0.9 2.3 -1.1 -0.3 0.1 -1.5
Lupus 0.5 0.8 1.7 1.1 -0.4 1.3 0.1
Neuroticism (2016) 0.6 0.9 2.4 0.8 -0.3 -0.8 -1.5
Primary Biliary Cirrhosis 2.3 3.3 10.2 -0.3 1.6 0.6 3.2
Rheumatoid Arthritis 1.0 1.4 5.0 0.3 0.3 0.5 2.2
Schizophrenia (2014) 1.1 2.5 5.5 -0.8 2.4 -0.5 1.8
Triglycerides 0.6 1.0 3.0 -1.7 0.3 0.6 0.8
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.9 -1.7 -0.9 0.5 -0.3
Ulcerative Colitis 1.4 2.0 2.9 1.7 0.4 1.7 1.4
Blood Eosinophil Count 0.8 6.4 23.3 -4.8 -0.8 -0.8 -1.1
Blood Platelet Count 0.6 6.7 10.9 -1.5 -3.3 2.6 -2.6
Blood Red Count 0.4 3.8 7.3 -2.7 -1.7 0.1 -2.2
Blood White Count 2.8 20.4 39.1 -1.2 -6.2 3.5 -5.4
Heel T-Score 0.1 1.1 1.8 0.4 -1.1 1.2 -1.4
BMI 1.2 6.9 9.7 -2.9 -3.1 1.1 -2.8
Height 0.8 15.7 31.5 3.5 -2.8 -3.4 -5.6
Waist Hip Ratio (WHR) 0.0 0.2 0.4 0.6 0.1 -0.6 -0.1
Systolic Blood Pressure 1.7 8.7 21.0 1.1 -4.6 1.8 -3.1
Smoking Status 1.5 3.6 11.0 0.6 1.7 0.0 3.3
Allergy or Eczema 1.4 3.7 8.2 0.8 2.4 -0.5 2.9
Cardiovascular Disease 0.8 2.8 7.1 0.8 -2.7 1.5 -0.9
Hypothyroidism (self reported) 0.8 1.7 3.8 -2.0 -0.1 -0.8 1.6
Respiratory disease 1.6 3.5 9.2 -1.6 -1.5 3.0 0.0
Type 2 Diabetes (T2D) (2018) 0.7 1.3 3.6 -1.9 0.5 0.5 1.1
Lung FEV1/FVC ratio 0.1 0.3 0.7 -0.3 0.6 0.2 0.8
Lung FVC 0.5 2.4 4.1 -1.1 2.0 0.6 2.0
Neuroticism 0.6 1.6 3.8 2.0 -0.8 -0.1 -1.3
Chronotype (morning person) 0.3 0.7 1.2 0.7 -1.0 1.1 -0.2
Hair Pigment 0.0 0.0 0.1 -0.0 0.1 -0.1 -0.3
Tanning 0.1 0.6 1.7 0.9 -0.1 1.3 -0.1
Hand grip strength (left) 0.9 2.4 5.3 -0.6 -0.8 -1.8 -2.3
Number of treatments/medications taken 0.6 1.0 2.1 0.4 -0.2 1.3 1.4
Average weekly spirits intake 0.5 0.6 1.1 -0.0 -0.7 1.0 -1.1
Sensitivity / hurt feelings 0.6 1.1 3.5 0.6 0.5 -1.9 -0.5
Frequency of depressed mood in last 2 weeks 1.4 2.0 3.9 1.3 -2.0 0.3 -1.5
Hearing difficulty/problems: Yes 0.9 1.4 2.8 0.7 1.7 -1.2 0.9
Relative age of first facial hair 0.9 1.8 3.6 -0.8 -1.6 -0.6 -1.9
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.8 -1.7 0.4 0.6 1.2
Ever used hormone-replacement therapy (HRT) 1.8 2.3 7.8 -0.3 1.0 0.6 2.8
Ever had hysterectomy (womb removed) 1.9 2.2 5.3 0.3 2.3 -0.0 1.8
Systolic blood pressure, automated reading 1.1 3.3 8.6 0.3 -2.9 1.4 -1.6
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 0.9 0.7 0.0 1.0 0.7
Angina 2.5 3.2 8.5 -0.4 1.9 0.9 2.9
Medication for hormone replacement therapy 1.8 2.0 4.3 0.7 1.8 -0.3 2.1
Vitamin and mineral supplements 1.4 1.9 3.7 0.6 -1.7 0.8 -1.9
Supplements: Zinc 3.6 3.9 7.9 -1.1 -2.8 2.2 -1.4
Medication: Co-codamol 0.8 0.9 2.9 -0.8 -0.1 0.2 1.7
Medication: Metformin 2.0 2.9 7.9 -0.9 1.6 0.6 2.8
Diabetes (father) 0.8 0.9 2.4 -0.7 1.5 -0.7 0.7
Diabetes (mother) 0.2 0.3 0.6 0.1 0.6 -0.8 0.3
Severe depression (siblings) 0.8 0.8 1.4 1.2 -0.6 0.6 -1.2
Pack years adult smoking proportion 0.1 0.1 0.3 -0.4 -0.3 0.2 0.6
Impedance of leg (right) 0.4 1.8 5.9 2.4 -0.9 0.2 -0.8
Leg fat-free mass (left) 0.6 2.9 6.3 -1.6 -1.5 -0.7 -2.5
Trunk fat percentage 0.4 1.6 3.9 -0.5 -1.3 2.0 -0.7
Hand grip strength (right) 1.6 4.3 11.3 -0.4 -1.9 -1.4 -3.4
Townsend deprivation index at recruitment 3.1 4.3 7.8 1.5 2.8 -1.1 2.4
Current tobacco smoking 1.4 2.3 5.9 0.8 1.6 0.1 2.4
Average weekly fortified wine intake 1.4 1.6 3.1 1.8 1.3 -0.1 1.3
Maternal smoking around birth 3.9 5.6 11.6 0.9 3.4 -0.8 3.1
Fed-up feelings 1.7 3.1 5.1 2.2 -1.6 -0.6 -2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.6 0.4 -1.6 0.2 -1.6
Relative age voice broke 1.0 1.5 2.1 -1.1 -1.3 1.5 -0.9
Taking other prescription medications 1.0 1.5 3.8 -0.8 -0.1 1.3 2.0
Age when periods started (menarche) 0.4 1.0 2.1 -0.9 -1.0 1.4 -0.4
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.8 -0.2 1.3 -0.4 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 2.9 1.1 -1.2 -1.0 -1.7
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.1 0.2 0.2 -0.1 -0.1
Qualifications: CSEs or equivalent 1.2 1.6 2.6 1.6 1.2 -1.5 0.5
Serious illness, injury or assault to yourself 2.8 3.4 7.6 -0.3 2.8 -0.2 2.4
High blood pressure 1.5 4.0 8.4 -0.1 -2.9 2.7 -0.8
Hayfever, allergic rhinitis or eczema 1.9 4.1 7.7 1.0 2.6 -0.9 2.8
Multivitamins +/- minerals 0.4 0.6 0.9 -0.9 0.8 -0.1 0.8
Stomach or abdominal pain in last month 0.2 0.2 0.5 0.5 0.3 0.7 -0.2
Supplements: Glucosamine 1.4 1.9 3.8 -1.9 -0.2 -1.9 -0.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 2.9 1.0 1.7 -0.5 0.6
Medication: Atenolol 2.4 3.0 8.9 0.3 -1.8 3.0 -0.0
Medication: Levothyroxine sodium 0.5 0.8 1.5 -1.1 0.4 -0.7 1.2
Sitting height 0.5 3.8 9.5 1.7 -1.0 -1.3 -3.1
Chronic bronchitis/emphysema (father) 0.3 0.3 1.0 0.2 -0.2 -1.0 -0.4
High blood pressure (mother) 3.3 4.6 7.2 0.3 -2.6 2.1 -2.7
Body mass index (BMI) 0.8 3.3 8.2 -2.9 -1.7 1.0 -1.1
Impedance of leg (left) 0.4 1.9 7.2 2.7 -0.4 0.5 -0.1
Leg predicted mass (left) 0.6 3.0 6.5 -1.7 -1.5 -0.8 -2.5
Trunk fat mass 0.5 2.1 3.3 -0.8 -1.8 1.2 -1.7
Waist circumference 0.6 2.4 3.6 -1.7 -1.9 0.5 -1.6
Number of incorrect matches in round 1.2 2.0 6.6 -0.6 1.0 0.3 2.6
Past tobacco smoking 0.5 1.0 2.2 -0.7 -0.4 1.0 -1.5
Alcohol usually taken with meals 1.2 1.9 4.0 0.4 1.8 -2.0 0.5
Nervous feelings 1.4 2.7 5.7 0.9 -2.4 0.7 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 0.7 -0.8 -0.2 -0.1
Hearing difficulty/problems with background noise 0.6 0.9 2.0 1.4 0.6 -1.1 0.6
Hair/balding pattern: Pattern 2 1.5 2.0 6.0 -0.6 -0.1 2.4 1.2
Had menopause 2.1 2.6 7.1 -1.5 0.5 0.9 2.7
Had other major operations 2.0 2.5 7.7 -0.0 -0.9 2.8 1.2
Forced vital capacity (FVC) 0.4 1.4 4.0 0.0 0.4 -2.0 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.3 0.9 -1.0 -0.3 -1.8
Ever unenthusiastic/disinterested for a whole week 2.9 3.5 6.6 -0.6 2.6 -2.0 1.9
Qualifications: None of the above 1.2 2.5 6.1 0.3 0.3 2.5 1.9
Financial difficulties in last 2 years 1.4 1.9 4.2 0.3 1.7 0.5 2.1
Mouth/teeth dental problems 0.4 0.7 2.2 -0.0 0.2 -1.5 -0.7
Heart attack 0.8 1.1 2.2 -0.2 1.2 -0.8 1.5
Allergy 0.5 1.1 2.9 0.0 -1.2 -0.1 -1.7
Pain all over the body in last month 1.9 2.0 4.9 0.0 1.8 -0.2 2.2
Diabetes (self-reported) 0.9 1.4 4.1 -0.3 1.1 0.4 2.0
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 3.1 -0.0 0.9 0.4 1.8
Medication: Ramipril 0.1 0.2 0.3 -0.4 -0.5 0.2 -0.5
Medication: Simvastatin 0.4 0.6 1.4 -0.4 -0.1 1.2 0.8
Fluid intelligence score 1.2 2.4 5.0 1.5 -1.1 -1.1 -2.2
Illnesses of siblings 0.7 1.0 3.1 -0.0 -0.7 -0.6 -1.8
Neuroticism score 1.0 2.0 5.2 2.3 -1.2 0.1 -1.2
Weight 0.9 4.3 8.1 -1.8 -2.4 -0.2 -2.8
Impedance of arm (right) 1.2 5.6 19.7 4.4 1.3 -0.1 1.0
Arm fat percentage (right) 0.1 0.6 1.1 -0.8 -0.6 1.0 -0.4
Trunk fat-free mass 1.1 6.2 13.0 -1.6 -1.9 -2.3 -3.6
Hip circumference 0.9 4.0 5.7 -2.0 -2.4 0.7 -2.4
Time employed in main current job 0.7 0.8 2.7 -0.4 -0.1 -0.4 -1.6
Alcohol intake versus 10 years previously 0.8 1.3 1.8 -1.1 1.3 -0.7 1.2
Father’s age at death 0.6 0.8 1.6 0.2 -1.0 -0.7 -1.3
Worrier / anxious feelings 1.2 2.3 3.5 1.9 -1.9 0.6 -1.4
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 3.0 1.7 0.5 0.2 0.4
Falls in the last year 1.0 1.3 2.6 -0.5 1.5 -0.5 1.6
Hair/balding pattern: Pattern 3 0.4 0.5 1.0 -1.0 -0.7 -0.2 -0.8
Number of live births 1.6 2.3 3.0 1.5 -1.5 1.7 -1.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 4.2 -0.3 0.4 -2.0 -1.1
Pulse rate 0.2 0.3 0.6 0.1 0.6 -0.8 -0.6
Happiness 0.4 0.5 1.0 0.6 0.1 -0.8 -1.0
Noisy workplace 0.4 0.5 1.1 1.0 -0.8 0.4 -0.2
Qualifications: A levels/AS levels or equivalent 2.6 5.9 13.8 -0.2 -1.8 -2.5 -3.7
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 2.9 0.5 0.4 1.7 0.8
Mouth/teeth dental problems: Dentures 1.0 1.8 3.3 -0.8 -1.8 -0.1 -1.8
Asthma 1.2 2.4 4.9 -1.9 -1.0 2.2 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 2.0 1.4 0.1 0.8 0.1
Medication: Cholesterol lowering 0.2 0.3 0.4 -0.6 -0.6 0.4 -0.6
Depression (self-reported) 0.1 0.1 0.4 0.7 -0.1 -0.2 0.1
Medication: Lansoprazole 2.2 2.5 3.3 1.8 0.8 1.8 1.7
Prospective memory result 1.4 1.7 6.4 -0.3 -0.5 2.5 0.4
Lung cancer (father) 0.2 0.3 0.5 -0.6 0.4 -0.2 0.7
Illnesses of mother 1.3 1.6 5.1 -0.0 1.2 -2.3 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.0 0.1 -0.1 -1.7 -1.1
Pulse wave Arterial Stiffness index 3.1 3.6 10.8 0.6 -1.8 3.3 0.2
Impedance of arm (left) 0.9 4.3 14.6 3.8 1.3 -0.1 1.0
Arm fat mass (right) 0.4 1.7 2.4 -1.5 -1.5 0.8 -1.3
Trunk predicted mass 1.0 5.9 12.5 -1.6 -1.9 -2.2 -3.5
Standing height 0.8 8.0 16.6 2.3 -1.9 -2.6 -4.1
Length of working week for main job 0.2 0.2 0.4 -0.6 0.4 0.4 -0.4
Exposure to tobacco smoke at home 2.2 2.4 4.4 1.1 2.1 0.8 1.9
Breastfed as a baby 0.7 0.8 1.2 -1.1 1.0 -0.4 0.9
Tense / ‘highly strung’ 0.2 0.3 0.7 0.5 -0.6 0.3 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.4 0.7 0.3 0.8 1.2
Hair/balding pattern: Pattern 4 0.7 1.6 3.3 -1.5 1.0 -1.8 0.1
Birth weight of first child 0.6 1.2 2.0 0.5 1.4 -1.1 1.1
Peak expiratory flow (PEF) 1.2 2.8 7.4 -1.2 1.3 -2.7 -0.6
Pulse wave reflection index 2.9 3.6 7.3 1.8 -1.9 2.7 0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 -0.7 0.3 -0.2 0.4
Loud music exposure frequency 1.0 1.1 2.0 0.9 1.0 0.7 1.4
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 7.1 -0.1 -1.1 -1.9 -2.7
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.8 0.8 1.7 0.3 1.2
Blood clot in the leg (DVT) 0.4 0.5 0.6 0.7 0.5 -0.8 -0.8
Medication: Paracetamol 0.6 1.0 1.7 1.3 1.3 0.4 0.7
Headache pain in last month 0.7 1.2 4.4 0.5 -0.5 2.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.1 0.1 1.5 -0.9 0.9
Glaucoma (self-reported) 2.5 2.9 8.2 -2.9 -1.0 1.4 0.6
Gout (self-reported) 0.3 0.4 0.6 0.6 -0.8 0.8 -0.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.8 -1.3 -0.5 -0.5 0.8
Medication: Amlodipine 0.6 0.8 2.2 -1.5 0.2 0.7 0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 0.4 -0.6 1.0 -0.1
Birth weight 0.3 0.7 1.7 0.4 0.2 1.3 0.9
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.8 0.0 -1.3 0.1 0.0
High blood pressure (siblings) 0.8 1.1 2.1 1.4 -0.6 -0.4 -1.4
Forced vital capacity (FVC), Best measure 0.3 1.2 3.3 0.4 -0.1 -1.8 -1.2
Body fat percentage 0.4 1.4 2.8 -0.8 -1.3 1.7 -0.8
Leg fat percentage (right) 0.7 2.5 3.8 -1.7 -1.9 1.3 -1.4
Arm fat-free mass (right) 1.2 6.1 10.2 -2.6 -2.6 -1.0 -3.2
Exposure to tobacco smoke outside home 5.7 7.6 16.7 -0.5 3.6 0.9 4.1
Comparative body size at age 10 0.5 1.5 2.2 -0.7 1.5 -1.4 1.1
Number of full brothers 0.3 0.4 1.5 -1.2 -0.1 -0.2 -0.4
Worry too long after embarrassment 0.4 0.7 2.1 1.5 -0.4 -0.2 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.3 0.1 0.3 0.9
Wheeze or whistling in the chest in last year 1.3 2.4 9.6 -3.1 0.1 0.1 0.1
Number of children fathered 0.8 0.9 1.5 -1.2 -0.9 1.2 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.3 0.0 -1.1 0.2 0.4
Age at first live birth 1.6 2.9 8.8 0.7 -1.4 -0.5 -3.0
Pulse wave peak to peak time 3.3 3.8 11.7 -0.5 1.8 -3.4 -0.3
Health satisfaction 0.6 0.8 2.5 -1.6 0.8 -0.1 0.5
Shortness of breath walking on level ground 1.2 1.5 2.2 -1.5 1.2 -1.0 1.1
Qualifications: College or University degree 0.8 2.5 5.4 0.1 -1.0 -1.9 -2.3
Eye problems/disorders: None of the above 0.4 0.4 0.7 0.5 0.7 -0.9 0.3
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.6 -0.7 0.8 -0.8 0.4
Emphysema/chronic bronchitis 0.6 0.7 1.5 -0.5 0.6 -0.7 1.2
Medication for pain relief, constipation, heartburn 0.6 1.0 2.1 -1.4 -1.1 0.5 -0.6
Neck or shoulder pain in last month 0.5 0.6 1.8 -0.8 0.3 0.3 1.3
Medication: Blood pressure 0.5 0.9 1.7 0.6 -1.2 1.3 -0.6
Angina (self-reported) 2.3 3.1 8.0 -0.2 2.0 0.7 2.8
Migraine (self-reported) 0.3 0.4 1.3 -1.1 0.3 -0.2 0.1
Medication: Ibuprofen 0.8 1.0 2.4 1.6 -0.6 0.8 -0.7
Medication: Allopurinol 0.7 0.9 2.0 1.4 1.1 -0.2 0.7
Medication: Omeprazole 1.4 1.7 4.0 -1.2 1.1 0.3 2.0
Medication: Seretide 50 evohaler 1.6 1.8 3.9 0.8 -1.5 0.7 -2.0
Mean time to correctly identify matches 3.3 6.3 14.1 2.0 1.9 1.9 3.8
Heart disease (mother) 1.1 1.3 2.1 -1.3 1.5 -0.1 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 -0.7 0.4 -0.5 0.4
Whole body fat mass 0.5 2.1 3.1 -1.2 -1.8 1.0 -1.7
Leg fat mass (right) 1.0 3.8 5.7 -1.8 -2.4 1.2 -2.1
Arm predicted mass (right) 1.1 5.4 8.4 -2.9 -2.0 -1.1 -2.8
Pulse rate, automated reading 0.2 0.7 1.6 -0.1 -1.0 0.1 -1.3
Alcohol intake frequency. 0.6 1.4 2.9 -1.4 -0.7 1.7 0.3
Comparative height size at age 10 0.9 4.9 8.9 2.6 -1.6 -1.1 -3.0
Number of full sisters 0.7 0.9 2.3 -1.5 0.9 -0.5 0.4
Suffer from ‘nerves’ 0.5 0.8 1.6 -0.5 -1.3 -0.6 -0.9
Overall health rating 0.8 1.8 5.1 -0.2 1.2 0.9 2.3
Chest pain or discomfort 0.4 0.6 1.4 0.9 0.1 1.2 -0.0
Had major operations 1.5 1.7 4.6 0.9 -0.5 2.1 1.1
Age at last live birth 1.6 2.4 6.0 1.2 -1.4 0.4 -2.4
Family relationship satisfaction 0.2 0.2 0.7 0.8 -0.1 -0.4 -0.2
Leg pain on walking 1.5 1.8 4.5 -2.1 0.2 1.5 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.0 -1.4 0.7 0.2 0.1
Commuting to job workplace: Car/motor vehicle 2.4 2.7 5.7 0.9 -2.4 0.4 -2.1
Illness, injury, bereavement, stress in last 2 years 3.8 4.7 10.7 0.3 -2.6 -0.9 -3.3
Medication: Aspirin 0.0 0.0 0.1 0.0 -0.3 -0.2 -0.0
Supplements: Vitamin C 0.5 0.6 1.1 -0.2 0.9 -0.7 1.1
Knee pain experienced in last month 0.6 1.0 2.0 -1.0 0.9 0.4 1.4
Hypertension (Self-reported) 1.0 2.8 6.2 -0.3 -2.5 2.2 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 3.5 0.2 -1.6 1.9 -0.2
Illnesses of father: Heart disease 0.5 0.7 2.3 -0.1 0.6 0.4 1.5
Illnesses of siblings: Diabetes 0.8 0.9 2.6 0.3 1.0 -0.3 1.6
Smoking status: Previous 0.3 0.5 1.0 -0.3 -0.0 -0.8 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 4.7 0.8 -1.0 -1.3 -2.2
Whole body fat-free mass 0.9 5.0 10.4 -1.8 -1.8 -1.7 -3.2
Leg fat-free mass (right) 0.4 2.3 4.5 -1.6 -1.2 -0.8 -2.1
Arm fat percentage (left) 0.2 0.8 1.4 -1.2 -0.7 1.0 -0.5
Average weekly red wine intake 0.4 0.6 1.6 -1.3 -0.9 -0.3 -0.3
Handedness (chirality/laterality): Left-handed 2.7 3.2 6.6 -0.8 2.6 -0.8 2.2
Mood swings 1.1 1.9 3.9 2.0 -1.2 0.7 -1.4
Loneliness, isolation 0.9 1.3 2.2 1.1 1.0 -0.8 1.5
Long-standing illness, disability or infirmity 3.6 5.6 10.0 -2.9 1.6 1.1 3.2
Ever had bowel cancer screening 1.7 2.0 5.0 2.2 0.5 1.4 0.8
Diabetes diagnosed by doctor 1.3 2.1 5.2 -1.3 1.2 0.1 2.3
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.6 1.4 1.6 0.2 0.7
Friendships satisfaction 0.5 0.6 1.2 -0.5 -0.3 -1.1 -0.9
Qualifications: nursing, teaching 1.1 1.7 3.0 -1.1 -0.4 -1.7 -1.6
Commuting to job workplace: Walk 0.3 0.3 0.7 0.7 0.3 -0.1 0.8
Eye problems/disorders: Cataract 1.2 1.4 2.4 1.4 -1.1 -0.1 -1.6
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 7.7 -0.7 -1.0 2.8 0.3
Medication for cholesterol 0.4 0.6 1.2 0.1 -0.1 -1.0 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.5 5.3 9.8 -1.3 2.9 -1.2 3.1
Back pain experienced in last month 0.5 0.7 1.6 -0.3 -0.8 1.3 0.8
Mineral and other dietary supplements 1.0 1.3 2.0 1.4 -0.9 1.0 -1.2
Breast cancer (self-reported) 0.4 0.4 1.3 1.2 -0.3 -0.2 -0.5
Asthma (self-reported) 1.1 2.2 5.5 -1.4 -1.0 2.3 0.2
Osteoporosis (self-reported) 1.0 1.3 1.8 0.2 1.4 -1.3 1.3
Osteoarthritis (self-reported) 0.5 0.7 1.6 -1.3 -0.1 0.6 0.8
Medication: Aspirin 0.1 0.1 0.3 0.1 0.2 -0.3 0.6
Medication: Gliclazide 0.4 0.4 0.9 -0.1 -0.1 -1.0 0.8
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 0.3 0.6 -0.2 0.7
Smoking status: Current 1.8 2.9 6.4 1.4 1.8 0.1 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.2 -0.4 -0.6 0.1 -1.1
Whole body water mass 0.9 5.2 10.8 -2.0 -1.9 -1.6 -3.3
Leg predicted mass (right) 0.4 2.3 4.6 -1.6 -1.2 -0.8 -2.1
Arm fat mass (left) 0.5 2.1 2.9 -1.7 -1.6 0.7 -1.5
Number of self-reported non-cancer illnesses 0.4 0.7 1.2 -0.9 -0.3 0.9 1.1
Average weekly champagne plus white wine intake 2.1 2.8 8.0 2.8 -0.3 -0.8 -1.6
Miserableness 1.5 2.7 6.8 2.6 -1.4 0.2 -1.4
Guilty feelings 0.3 0.4 0.8 0.9 -0.2 0.9 0.1
Wears glasses or contact lenses 0.1 0.1 0.4 -0.3 -0.0 0.6 0.2
Ever taken oral contraceptive pill 2.2 2.4 3.8 1.3 2.0 1.0 1.8
Hearing aid user 0.0 0.1 0.1 -0.3 0.0 -0.2 -0.3
Mother’s age at death 0.2 0.3 0.6 0.2 0.5 0.5 0.8
Financial situation satisfaction 1.3 1.6 3.6 -0.4 1.9 -0.4 1.5
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 0.4 -0.3 -0.4 -0.6
Commuting to job workplace: Public transport 0.9 1.1 2.9 -1.7 1.0 -0.3 0.6
Eye problems/disorders: Glaucoma 2.6 3.0 5.8 -2.4 -2.0 1.3 -0.7
Medication: Blood pressure 0.7 1.3 3.4 -0.5 -1.1 1.8 0.6
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.2 -0.6 0.5 1.5 1.1
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.4 -0.3 -0.2 -0.2 -0.6
High cholesterol (Self-reported) 0.1 0.2 0.6 0.2 -0.2 0.8 0.3
Medication: Bendroflumethiazide 2.0 3.1 6.0 0.6 -2.5 0.7 -2.4
Medication: Paracetamol 0.4 0.7 1.5 0.9 1.2 0.1 0.5
Medication: Lisinopril 1.8 2.4 4.3 1.9 1.1 -0.2 2.1
Medication: Atorvastatin 0.9 1.1 3.0 -0.0 -0.3 -1.2 -1.7
Illnesses of father: High blood pressure 2.7 3.4 8.4 0.1 -2.2 -0.4 -2.9
Alcohol drinker status: Never 1.7 2.1 8.2 -2.9 -0.3 -0.1 -0.1
Ever smoked 0.5 0.9 1.4 1.0 0.5 -1.2 0.9
Basal metabolic rate 0.9 5.1 10.6 -2.0 -2.1 -1.3 -3.2
Leg fat percentage (left) 0.5 1.9 2.6 -1.6 -1.6 1.4 -0.8
Arm fat-free mass (left) 1.0 5.2 9.4 -2.2 -2.3 -1.1 -3.1
Number of operations (self-reported) 2.0 2.9 6.2 0.0 0.5 2.5 2.2
Average weekly beer plus cider intake 0.8 1.1 2.4 -1.5 -1.0 0.4 -1.0
Irritability 0.7 1.2 2.0 1.0 -1.4 1.0 -0.9
Risk taking 0.9 1.4 2.8 0.2 1.7 0.5 1.5
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.7 0.9 0.7 1.2 1.9
Fractured/broken bones in last 5 years 0.7 0.9 1.3 1.0 1.1 0.6 0.9
Age started oral contraceptive pill 2.2 2.8 5.9 -1.1 -2.4 1.4 -1.5
Diastolic blood pressure, automated reading 2.2 6.7 14.2 -0.0 -3.8 0.6 -3.5
Ever depressed for a whole week 0.4 0.6 1.1 1.0 0.6 0.2 0.8
Unable to work because of sickness or disability 0.4 0.6 1.3 0.6 -0.3 1.2 0.7
Commuting to job workplace: Cycle 2.9 3.5 9.4 0.6 2.0 -3.1 -0.7
Myopia 0.4 0.7 1.8 1.3 0.5 -0.6 0.4
Vascular/heart problems diagnosed by doctor 0.7 2.0 3.7 0.7 1.9 -1.9 0.3
Cholesterol lowering medication 0.2 0.3 0.7 -0.3 -0.5 0.9 0.2
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.4 -0.7 0.8 0.5 1.8
Pain experienced in last month 0.6 0.9 2.4 -0.6 0.8 -1.5 -0.6
Supplements: Calcium 0.2 0.2 0.5 0.3 0.1 -0.3 0.7
Basal cell carcinoma (self-reported) 0.7 0.8 2.4 0.3 0.7 -1.6 -0.4
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.0 -0.4 1.3 -1.1 1.4
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 0.7 0.8 0.8 -0.9 -0.7
Heart disease (siblings) 1.9 2.4 4.7 -1.7 0.3 2.2 1.4
Alcohol drinker status: Previous 2.1 2.4 4.8 0.6 1.0 1.9 2.2
Pack years of smoking 0.3 0.4 1.0 -0.3 -1.0 0.8 0.0
Impedance of whole body 0.7 3.8 14.1 3.8 0.6 0.3 0.7
Leg fat mass (left) 0.8 3.2 4.9 -1.7 -2.2 1.2 -1.9
Arm predicted mass (left) 1.0 5.0 9.5 -1.9 -2.5 -0.9 -3.1