Hub : Genes

PFKFB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.1206	0.0512	3.9e-03	0.026	NA	0.005	NA	-0.005	0.01500	NA	0.17000	NA	0.9300
2	GTEx	Nerve Tibial	0.0815	0.0362	9.3e-03	-0.003	NA	-0.004	NA	-0.004	0.63000	NA	0.98000	NA	0.8800
3	YFS	Blood	0.0186	0.0096	2.4e-02	0.011	0.002	0.005	0.007	0.007	0.00013	8.9e-02	0.00520	0.0015	0.0017
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0568	0.0265	1.4e-05	0.011	0.037	0.025	NA	0.019	0.02000	5.1e-05	0.00072	NA	0.0031

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.6	5.1	-0.6	2.3	-0.4	0.9
Bipolar Disorder or Schizophrenia	1.8	4.3	12.5	-1.0	3.5	-0.8	1.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	1.1	-0.7	-0.2	-1.0
Depression (Nagel 2018)	1.8	2.7	5.5	-1.1	-2.3	0.8	-1.9
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	0.6	-0.3	-0.4	-1.0
Neuroticism (Nagel 2018)	0.6	1.5	2.6	1.4	-1.1	-0.3	-1.6
Schizophrenia (2018)	1.2	2.5	6.4	-0.8	2.5	-0.7	1.5
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	-0.2	0.6	-1.1	0.3
Worry (Nagel 2018)	1.1	2.3	3.9	1.3	-2.0	0.3	-1.8
Alzheimer’s Disease (in mother)	0.8	1.0	1.5	-0.1	1.2	-0.9	1.2
Alzheimer’s Disease (in father)	2.2	2.4	5.0	-1.2	-1.7	-0.5	-2.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-1.2	0.7	-1.0	0.2
Crohns Disease (2017)	0.3	0.6	1.1	0.6	-0.0	0.9	1.0
Irritable Bowel Disease (IBD)	0.6	1.4	2.9	0.0	0.7	1.5	1.7
Ulcerative Colitis (UC)	1.3	2.5	4.2	-0.7	1.3	1.9	2.0
Major Depression (MDD)	0.3	0.4	1.0	0.4	1.0	-0.2	0.5
Reaction Time	2.9	5.6	10.1	2.7	1.9	1.4	3.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.0	1.7	-0.5	-0.1	-1.3
Breast Cancer	0.3	0.8	2.3	-1.5	0.1	0.7	0.6
Ovarian Cancer	0.5	0.7	1.4	1.0	-0.6	1.2	0.2
Prostate Cancer	1.4	1.9	4.4	-1.0	2.1	-1.4	0.5
Age at First Birth	0.7	1.0	1.3	1.1	-1.1	-0.5	-1.1
Bipolar Disorder (2011)	0.1	0.1	0.2	0.1	0.4	-0.4	-0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.4	0.0	0.9	0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.5	-0.6	0.4	0.1	-0.7
Crohns Disease (2012)	0.6	0.9	2.4	0.6	0.4	0.8	1.5
Mean Putamen Volume	1.0	1.1	2.0	-1.1	1.2	0.1	1.4
Fasting Glucose	1.4	1.7	3.7	0.1	1.9	-1.0	1.4
HbA1C	0.3	0.4	0.7	0.1	0.7	-0.8	0.5
HDL Cholesterol	0.5	0.9	1.6	-1.3	0.3	1.2	0.7
LDL Cholesterol	0.6	0.9	2.3	-1.1	-0.3	0.1	-1.5
Lupus	0.5	0.8	1.7	1.1	-0.4	1.3	0.1
Neuroticism (2016)	0.6	0.9	2.4	0.8	-0.3	-0.8	-1.5
Primary Biliary Cirrhosis	2.3	3.3	10.2	-0.3	1.6	0.6	3.2
Rheumatoid Arthritis	1.0	1.4	5.0	0.3	0.3	0.5	2.2
Schizophrenia (2014)	1.1	2.5	5.5	-0.8	2.4	-0.5	1.8
Triglycerides	0.6	1.0	3.0	-1.7	0.3	0.6	0.8
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.9	-1.7	-0.9	0.5	-0.3
Ulcerative Colitis	1.4	2.0	2.9	1.7	0.4	1.7	1.4
Blood Eosinophil Count	0.8	6.4	23.3	-4.8	-0.8	-0.8	-1.1
Blood Platelet Count	0.6	6.7	10.9	-1.5	-3.3	2.6	-2.6
Blood Red Count	0.4	3.8	7.3	-2.7	-1.7	0.1	-2.2
Blood White Count	2.8	20.4	39.1	-1.2	-6.2	3.5	-5.4
Heel T-Score	0.1	1.1	1.8	0.4	-1.1	1.2	-1.4
BMI	1.2	6.9	9.7	-2.9	-3.1	1.1	-2.8
Height	0.8	15.7	31.5	3.5	-2.8	-3.4	-5.6
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.6	0.1	-0.6	-0.1
Systolic Blood Pressure	1.7	8.7	21.0	1.1	-4.6	1.8	-3.1
Smoking Status	1.5	3.6	11.0	0.6	1.7	0.0	3.3
Allergy or Eczema	1.4	3.7	8.2	0.8	2.4	-0.5	2.9
Cardiovascular Disease	0.8	2.8	7.1	0.8	-2.7	1.5	-0.9
Hypothyroidism (self reported)	0.8	1.7	3.8	-2.0	-0.1	-0.8	1.6
Respiratory disease	1.6	3.5	9.2	-1.6	-1.5	3.0	0.0
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.6	-1.9	0.5	0.5	1.1
Lung FEV1/FVC ratio	0.1	0.3	0.7	-0.3	0.6	0.2	0.8
Lung FVC	0.5	2.4	4.1	-1.1	2.0	0.6	2.0
Neuroticism	0.6	1.6	3.8	2.0	-0.8	-0.1	-1.3
Chronotype (morning person)	0.3	0.7	1.2	0.7	-1.0	1.1	-0.2
Hair Pigment	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.3
Tanning	0.1	0.6	1.7	0.9	-0.1	1.3	-0.1
Hand grip strength (left)	0.9	2.4	5.3	-0.6	-0.8	-1.8	-2.3
Number of treatments/medications taken	0.6	1.0	2.1	0.4	-0.2	1.3	1.4
Average weekly spirits intake	0.5	0.6	1.1	-0.0	-0.7	1.0	-1.1
Sensitivity / hurt feelings	0.6	1.1	3.5	0.6	0.5	-1.9	-0.5
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.9	1.3	-2.0	0.3	-1.5
Hearing difficulty/problems: Yes	0.9	1.4	2.8	0.7	1.7	-1.2	0.9
Relative age of first facial hair	0.9	1.8	3.6	-0.8	-1.6	-0.6	-1.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.8	-1.7	0.4	0.6	1.2
Ever used hormone-replacement therapy (HRT)	1.8	2.3	7.8	-0.3	1.0	0.6	2.8
Ever had hysterectomy (womb removed)	1.9	2.2	5.3	0.3	2.3	-0.0	1.8
Systolic blood pressure, automated reading	1.1	3.3	8.6	0.3	-2.9	1.4	-1.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	0.7	0.0	1.0	0.7
Angina	2.5	3.2	8.5	-0.4	1.9	0.9	2.9
Medication for hormone replacement therapy	1.8	2.0	4.3	0.7	1.8	-0.3	2.1
Vitamin and mineral supplements	1.4	1.9	3.7	0.6	-1.7	0.8	-1.9
Supplements: Zinc	3.6	3.9	7.9	-1.1	-2.8	2.2	-1.4
Medication: Co-codamol	0.8	0.9	2.9	-0.8	-0.1	0.2	1.7
Medication: Metformin	2.0	2.9	7.9	-0.9	1.6	0.6	2.8
Diabetes (father)	0.8	0.9	2.4	-0.7	1.5	-0.7	0.7
Diabetes (mother)	0.2	0.3	0.6	0.1	0.6	-0.8	0.3
Severe depression (siblings)	0.8	0.8	1.4	1.2	-0.6	0.6	-1.2
Pack years adult smoking proportion	0.1	0.1	0.3	-0.4	-0.3	0.2	0.6
Impedance of leg (right)	0.4	1.8	5.9	2.4	-0.9	0.2	-0.8
Leg fat-free mass (left)	0.6	2.9	6.3	-1.6	-1.5	-0.7	-2.5
Trunk fat percentage	0.4	1.6	3.9	-0.5	-1.3	2.0	-0.7
Hand grip strength (right)	1.6	4.3	11.3	-0.4	-1.9	-1.4	-3.4
Townsend deprivation index at recruitment	3.1	4.3	7.8	1.5	2.8	-1.1	2.4
Current tobacco smoking	1.4	2.3	5.9	0.8	1.6	0.1	2.4
Average weekly fortified wine intake	1.4	1.6	3.1	1.8	1.3	-0.1	1.3
Maternal smoking around birth	3.9	5.6	11.6	0.9	3.4	-0.8	3.1
Fed-up feelings	1.7	3.1	5.1	2.2	-1.6	-0.6	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.6	0.4	-1.6	0.2	-1.6
Relative age voice broke	1.0	1.5	2.1	-1.1	-1.3	1.5	-0.9
Taking other prescription medications	1.0	1.5	3.8	-0.8	-0.1	1.3	2.0
Age when periods started (menarche)	0.4	1.0	2.1	-0.9	-1.0	1.4	-0.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.8	-0.2	1.3	-0.4	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.9	1.1	-1.2	-1.0	-1.7
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.2	0.2	-0.1	-0.1
Qualifications: CSEs or equivalent	1.2	1.6	2.6	1.6	1.2	-1.5	0.5
Serious illness, injury or assault to yourself	2.8	3.4	7.6	-0.3	2.8	-0.2	2.4
High blood pressure	1.5	4.0	8.4	-0.1	-2.9	2.7	-0.8
Hayfever, allergic rhinitis or eczema	1.9	4.1	7.7	1.0	2.6	-0.9	2.8
Multivitamins +/- minerals	0.4	0.6	0.9	-0.9	0.8	-0.1	0.8
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.5	0.3	0.7	-0.2
Supplements: Glucosamine	1.4	1.9	3.8	-1.9	-0.2	-1.9	-0.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.9	1.0	1.7	-0.5	0.6
Medication: Atenolol	2.4	3.0	8.9	0.3	-1.8	3.0	-0.0
Medication: Levothyroxine sodium	0.5	0.8	1.5	-1.1	0.4	-0.7	1.2
Sitting height	0.5	3.8	9.5	1.7	-1.0	-1.3	-3.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	0.2	-0.2	-1.0	-0.4
High blood pressure (mother)	3.3	4.6	7.2	0.3	-2.6	2.1	-2.7
Body mass index (BMI)	0.8	3.3	8.2	-2.9	-1.7	1.0	-1.1
Impedance of leg (left)	0.4	1.9	7.2	2.7	-0.4	0.5	-0.1
Leg predicted mass (left)	0.6	3.0	6.5	-1.7	-1.5	-0.8	-2.5
Trunk fat mass	0.5	2.1	3.3	-0.8	-1.8	1.2	-1.7
Waist circumference	0.6	2.4	3.6	-1.7	-1.9	0.5	-1.6
Number of incorrect matches in round	1.2	2.0	6.6	-0.6	1.0	0.3	2.6
Past tobacco smoking	0.5	1.0	2.2	-0.7	-0.4	1.0	-1.5
Alcohol usually taken with meals	1.2	1.9	4.0	0.4	1.8	-2.0	0.5
Nervous feelings	1.4	2.7	5.7	0.9	-2.4	0.7	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.7	-0.8	-0.2	-0.1
Hearing difficulty/problems with background noise	0.6	0.9	2.0	1.4	0.6	-1.1	0.6
Hair/balding pattern: Pattern 2	1.5	2.0	6.0	-0.6	-0.1	2.4	1.2
Had menopause	2.1	2.6	7.1	-1.5	0.5	0.9	2.7
Had other major operations	2.0	2.5	7.7	-0.0	-0.9	2.8	1.2
Forced vital capacity (FVC)	0.4	1.4	4.0	0.0	0.4	-2.0	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.3	0.9	-1.0	-0.3	-1.8
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	6.6	-0.6	2.6	-2.0	1.9
Qualifications: None of the above	1.2	2.5	6.1	0.3	0.3	2.5	1.9
Financial difficulties in last 2 years	1.4	1.9	4.2	0.3	1.7	0.5	2.1
Mouth/teeth dental problems	0.4	0.7	2.2	-0.0	0.2	-1.5	-0.7
Heart attack	0.8	1.1	2.2	-0.2	1.2	-0.8	1.5
Allergy	0.5	1.1	2.9	0.0	-1.2	-0.1	-1.7
Pain all over the body in last month	1.9	2.0	4.9	0.0	1.8	-0.2	2.2
Diabetes (self-reported)	0.9	1.4	4.1	-0.3	1.1	0.4	2.0
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.1	-0.0	0.9	0.4	1.8
Medication: Ramipril	0.1	0.2	0.3	-0.4	-0.5	0.2	-0.5
Medication: Simvastatin	0.4	0.6	1.4	-0.4	-0.1	1.2	0.8
Fluid intelligence score	1.2	2.4	5.0	1.5	-1.1	-1.1	-2.2
Illnesses of siblings	0.7	1.0	3.1	-0.0	-0.7	-0.6	-1.8
Neuroticism score	1.0	2.0	5.2	2.3	-1.2	0.1	-1.2
Weight	0.9	4.3	8.1	-1.8	-2.4	-0.2	-2.8
Impedance of arm (right)	1.2	5.6	19.7	4.4	1.3	-0.1	1.0
Arm fat percentage (right)	0.1	0.6	1.1	-0.8	-0.6	1.0	-0.4
Trunk fat-free mass	1.1	6.2	13.0	-1.6	-1.9	-2.3	-3.6
Hip circumference	0.9	4.0	5.7	-2.0	-2.4	0.7	-2.4
Time employed in main current job	0.7	0.8	2.7	-0.4	-0.1	-0.4	-1.6
Alcohol intake versus 10 years previously	0.8	1.3	1.8	-1.1	1.3	-0.7	1.2
Father’s age at death	0.6	0.8	1.6	0.2	-1.0	-0.7	-1.3
Worrier / anxious feelings	1.2	2.3	3.5	1.9	-1.9	0.6	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	3.0	1.7	0.5	0.2	0.4
Falls in the last year	1.0	1.3	2.6	-0.5	1.5	-0.5	1.6
Hair/balding pattern: Pattern 3	0.4	0.5	1.0	-1.0	-0.7	-0.2	-0.8
Number of live births	1.6	2.3	3.0	1.5	-1.5	1.7	-1.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.2	-0.3	0.4	-2.0	-1.1
Pulse rate	0.2	0.3	0.6	0.1	0.6	-0.8	-0.6
Happiness	0.4	0.5	1.0	0.6	0.1	-0.8	-1.0
Noisy workplace	0.4	0.5	1.1	1.0	-0.8	0.4	-0.2
Qualifications: A levels/AS levels or equivalent	2.6	5.9	13.8	-0.2	-1.8	-2.5	-3.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.9	0.5	0.4	1.7	0.8
Mouth/teeth dental problems: Dentures	1.0	1.8	3.3	-0.8	-1.8	-0.1	-1.8
Asthma	1.2	2.4	4.9	-1.9	-1.0	2.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.0	1.4	0.1	0.8	0.1
Medication: Cholesterol lowering	0.2	0.3	0.4	-0.6	-0.6	0.4	-0.6
Depression (self-reported)	0.1	0.1	0.4	0.7	-0.1	-0.2	0.1
Medication: Lansoprazole	2.2	2.5	3.3	1.8	0.8	1.8	1.7
Prospective memory result	1.4	1.7	6.4	-0.3	-0.5	2.5	0.4
Lung cancer (father)	0.2	0.3	0.5	-0.6	0.4	-0.2	0.7
Illnesses of mother	1.3	1.6	5.1	-0.0	1.2	-2.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.0	0.1	-0.1	-1.7	-1.1
Pulse wave Arterial Stiffness index	3.1	3.6	10.8	0.6	-1.8	3.3	0.2
Impedance of arm (left)	0.9	4.3	14.6	3.8	1.3	-0.1	1.0
Arm fat mass (right)	0.4	1.7	2.4	-1.5	-1.5	0.8	-1.3
Trunk predicted mass	1.0	5.9	12.5	-1.6	-1.9	-2.2	-3.5
Standing height	0.8	8.0	16.6	2.3	-1.9	-2.6	-4.1
Length of working week for main job	0.2	0.2	0.4	-0.6	0.4	0.4	-0.4
Exposure to tobacco smoke at home	2.2	2.4	4.4	1.1	2.1	0.8	1.9
Breastfed as a baby	0.7	0.8	1.2	-1.1	1.0	-0.4	0.9
Tense / ‘highly strung’	0.2	0.3	0.7	0.5	-0.6	0.3	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.4	0.7	0.3	0.8	1.2
Hair/balding pattern: Pattern 4	0.7	1.6	3.3	-1.5	1.0	-1.8	0.1
Birth weight of first child	0.6	1.2	2.0	0.5	1.4	-1.1	1.1
Peak expiratory flow (PEF)	1.2	2.8	7.4	-1.2	1.3	-2.7	-0.6
Pulse wave reflection index	2.9	3.6	7.3	1.8	-1.9	2.7	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.7	0.3	-0.2	0.4
Loud music exposure frequency	1.0	1.1	2.0	0.9	1.0	0.7	1.4
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	7.1	-0.1	-1.1	-1.9	-2.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.8	0.8	1.7	0.3	1.2
Blood clot in the leg (DVT)	0.4	0.5	0.6	0.7	0.5	-0.8	-0.8
Medication: Paracetamol	0.6	1.0	1.7	1.3	1.3	0.4	0.7
Headache pain in last month	0.7	1.2	4.4	0.5	-0.5	2.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.1	0.1	1.5	-0.9	0.9
Glaucoma (self-reported)	2.5	2.9	8.2	-2.9	-1.0	1.4	0.6
Gout (self-reported)	0.3	0.4	0.6	0.6	-0.8	0.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.8	-1.3	-0.5	-0.5	0.8
Medication: Amlodipine	0.6	0.8	2.2	-1.5	0.2	0.7	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.4	-0.6	1.0	-0.1
Birth weight	0.3	0.7	1.7	0.4	0.2	1.3	0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.8	0.0	-1.3	0.1	0.0
High blood pressure (siblings)	0.8	1.1	2.1	1.4	-0.6	-0.4	-1.4
Forced vital capacity (FVC), Best measure	0.3	1.2	3.3	0.4	-0.1	-1.8	-1.2
Body fat percentage	0.4	1.4	2.8	-0.8	-1.3	1.7	-0.8
Leg fat percentage (right)	0.7	2.5	3.8	-1.7	-1.9	1.3	-1.4
Arm fat-free mass (right)	1.2	6.1	10.2	-2.6	-2.6	-1.0	-3.2
Exposure to tobacco smoke outside home	5.7	7.6	16.7	-0.5	3.6	0.9	4.1
Comparative body size at age 10	0.5	1.5	2.2	-0.7	1.5	-1.4	1.1
Number of full brothers	0.3	0.4	1.5	-1.2	-0.1	-0.2	-0.4
Worry too long after embarrassment	0.4	0.7	2.1	1.5	-0.4	-0.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.3	0.1	0.3	0.9
Wheeze or whistling in the chest in last year	1.3	2.4	9.6	-3.1	0.1	0.1	0.1
Number of children fathered	0.8	0.9	1.5	-1.2	-0.9	1.2	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.3	0.0	-1.1	0.2	0.4
Age at first live birth	1.6	2.9	8.8	0.7	-1.4	-0.5	-3.0
Pulse wave peak to peak time	3.3	3.8	11.7	-0.5	1.8	-3.4	-0.3
Health satisfaction	0.6	0.8	2.5	-1.6	0.8	-0.1	0.5
Shortness of breath walking on level ground	1.2	1.5	2.2	-1.5	1.2	-1.0	1.1
Qualifications: College or University degree	0.8	2.5	5.4	0.1	-1.0	-1.9	-2.3
Eye problems/disorders: None of the above	0.4	0.4	0.7	0.5	0.7	-0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.6	-0.7	0.8	-0.8	0.4
Emphysema/chronic bronchitis	0.6	0.7	1.5	-0.5	0.6	-0.7	1.2
Medication for pain relief, constipation, heartburn	0.6	1.0	2.1	-1.4	-1.1	0.5	-0.6
Neck or shoulder pain in last month	0.5	0.6	1.8	-0.8	0.3	0.3	1.3
Medication: Blood pressure	0.5	0.9	1.7	0.6	-1.2	1.3	-0.6
Angina (self-reported)	2.3	3.1	8.0	-0.2	2.0	0.7	2.8
Migraine (self-reported)	0.3	0.4	1.3	-1.1	0.3	-0.2	0.1
Medication: Ibuprofen	0.8	1.0	2.4	1.6	-0.6	0.8	-0.7
Medication: Allopurinol	0.7	0.9	2.0	1.4	1.1	-0.2	0.7
Medication: Omeprazole	1.4	1.7	4.0	-1.2	1.1	0.3	2.0
Medication: Seretide 50 evohaler	1.6	1.8	3.9	0.8	-1.5	0.7	-2.0
Mean time to correctly identify matches	3.3	6.3	14.1	2.0	1.9	1.9	3.8
Heart disease (mother)	1.1	1.3	2.1	-1.3	1.5	-0.1	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.7	0.4	-0.5	0.4
Whole body fat mass	0.5	2.1	3.1	-1.2	-1.8	1.0	-1.7
Leg fat mass (right)	1.0	3.8	5.7	-1.8	-2.4	1.2	-2.1
Arm predicted mass (right)	1.1	5.4	8.4	-2.9	-2.0	-1.1	-2.8
Pulse rate, automated reading	0.2	0.7	1.6	-0.1	-1.0	0.1	-1.3
Alcohol intake frequency.	0.6	1.4	2.9	-1.4	-0.7	1.7	0.3
Comparative height size at age 10	0.9	4.9	8.9	2.6	-1.6	-1.1	-3.0
Number of full sisters	0.7	0.9	2.3	-1.5	0.9	-0.5	0.4
Suffer from ‘nerves’	0.5	0.8	1.6	-0.5	-1.3	-0.6	-0.9
Overall health rating	0.8	1.8	5.1	-0.2	1.2	0.9	2.3
Chest pain or discomfort	0.4	0.6	1.4	0.9	0.1	1.2	-0.0
Had major operations	1.5	1.7	4.6	0.9	-0.5	2.1	1.1
Age at last live birth	1.6	2.4	6.0	1.2	-1.4	0.4	-2.4
Family relationship satisfaction	0.2	0.2	0.7	0.8	-0.1	-0.4	-0.2
Leg pain on walking	1.5	1.8	4.5	-2.1	0.2	1.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	-1.4	0.7	0.2	0.1
Commuting to job workplace: Car/motor vehicle	2.4	2.7	5.7	0.9	-2.4	0.4	-2.1
Illness, injury, bereavement, stress in last 2 years	3.8	4.7	10.7	0.3	-2.6	-0.9	-3.3
Medication: Aspirin	0.0	0.0	0.1	0.0	-0.3	-0.2	-0.0
Supplements: Vitamin C	0.5	0.6	1.1	-0.2	0.9	-0.7	1.1
Knee pain experienced in last month	0.6	1.0	2.0	-1.0	0.9	0.4	1.4
Hypertension (Self-reported)	1.0	2.8	6.2	-0.3	-2.5	2.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.5	0.2	-1.6	1.9	-0.2
Illnesses of father: Heart disease	0.5	0.7	2.3	-0.1	0.6	0.4	1.5
Illnesses of siblings: Diabetes	0.8	0.9	2.6	0.3	1.0	-0.3	1.6
Smoking status: Previous	0.3	0.5	1.0	-0.3	-0.0	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.7	0.8	-1.0	-1.3	-2.2
Whole body fat-free mass	0.9	5.0	10.4	-1.8	-1.8	-1.7	-3.2
Leg fat-free mass (right)	0.4	2.3	4.5	-1.6	-1.2	-0.8	-2.1
Arm fat percentage (left)	0.2	0.8	1.4	-1.2	-0.7	1.0	-0.5
Average weekly red wine intake	0.4	0.6	1.6	-1.3	-0.9	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	2.7	3.2	6.6	-0.8	2.6	-0.8	2.2
Mood swings	1.1	1.9	3.9	2.0	-1.2	0.7	-1.4
Loneliness, isolation	0.9	1.3	2.2	1.1	1.0	-0.8	1.5
Long-standing illness, disability or infirmity	3.6	5.6	10.0	-2.9	1.6	1.1	3.2
Ever had bowel cancer screening	1.7	2.0	5.0	2.2	0.5	1.4	0.8
Diabetes diagnosed by doctor	1.3	2.1	5.2	-1.3	1.2	0.1	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.6	1.4	1.6	0.2	0.7
Friendships satisfaction	0.5	0.6	1.2	-0.5	-0.3	-1.1	-0.9
Qualifications: nursing, teaching	1.1	1.7	3.0	-1.1	-0.4	-1.7	-1.6
Commuting to job workplace: Walk	0.3	0.3	0.7	0.7	0.3	-0.1	0.8
Eye problems/disorders: Cataract	1.2	1.4	2.4	1.4	-1.1	-0.1	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	7.7	-0.7	-1.0	2.8	0.3
Medication for cholesterol	0.4	0.6	1.2	0.1	-0.1	-1.0	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.5	5.3	9.8	-1.3	2.9	-1.2	3.1
Back pain experienced in last month	0.5	0.7	1.6	-0.3	-0.8	1.3	0.8
Mineral and other dietary supplements	1.0	1.3	2.0	1.4	-0.9	1.0	-1.2
Breast cancer (self-reported)	0.4	0.4	1.3	1.2	-0.3	-0.2	-0.5
Asthma (self-reported)	1.1	2.2	5.5	-1.4	-1.0	2.3	0.2
Osteoporosis (self-reported)	1.0	1.3	1.8	0.2	1.4	-1.3	1.3
Osteoarthritis (self-reported)	0.5	0.7	1.6	-1.3	-0.1	0.6	0.8
Medication: Aspirin	0.1	0.1	0.3	0.1	0.2	-0.3	0.6
Medication: Gliclazide	0.4	0.4	0.9	-0.1	-0.1	-1.0	0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	0.3	0.6	-0.2	0.7
Smoking status: Current	1.8	2.9	6.4	1.4	1.8	0.1	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.2	-0.4	-0.6	0.1	-1.1
Whole body water mass	0.9	5.2	10.8	-2.0	-1.9	-1.6	-3.3
Leg predicted mass (right)	0.4	2.3	4.6	-1.6	-1.2	-0.8	-2.1
Arm fat mass (left)	0.5	2.1	2.9	-1.7	-1.6	0.7	-1.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.2	-0.9	-0.3	0.9	1.1
Average weekly champagne plus white wine intake	2.1	2.8	8.0	2.8	-0.3	-0.8	-1.6
Miserableness	1.5	2.7	6.8	2.6	-1.4	0.2	-1.4
Guilty feelings	0.3	0.4	0.8	0.9	-0.2	0.9	0.1
Wears glasses or contact lenses	0.1	0.1	0.4	-0.3	-0.0	0.6	0.2
Ever taken oral contraceptive pill	2.2	2.4	3.8	1.3	2.0	1.0	1.8
Hearing aid user	0.0	0.1	0.1	-0.3	0.0	-0.2	-0.3
Mother’s age at death	0.2	0.3	0.6	0.2	0.5	0.5	0.8
Financial situation satisfaction	1.3	1.6	3.6	-0.4	1.9	-0.4	1.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.4	-0.3	-0.4	-0.6
Commuting to job workplace: Public transport	0.9	1.1	2.9	-1.7	1.0	-0.3	0.6
Eye problems/disorders: Glaucoma	2.6	3.0	5.8	-2.4	-2.0	1.3	-0.7
Medication: Blood pressure	0.7	1.3	3.4	-0.5	-1.1	1.8	0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.2	-0.6	0.5	1.5	1.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.6
High cholesterol (Self-reported)	0.1	0.2	0.6	0.2	-0.2	0.8	0.3
Medication: Bendroflumethiazide	2.0	3.1	6.0	0.6	-2.5	0.7	-2.4
Medication: Paracetamol	0.4	0.7	1.5	0.9	1.2	0.1	0.5
Medication: Lisinopril	1.8	2.4	4.3	1.9	1.1	-0.2	2.1
Medication: Atorvastatin	0.9	1.1	3.0	-0.0	-0.3	-1.2	-1.7
Illnesses of father: High blood pressure	2.7	3.4	8.4	0.1	-2.2	-0.4	-2.9
Alcohol drinker status: Never	1.7	2.1	8.2	-2.9	-0.3	-0.1	-0.1
Ever smoked	0.5	0.9	1.4	1.0	0.5	-1.2	0.9
Basal metabolic rate	0.9	5.1	10.6	-2.0	-2.1	-1.3	-3.2
Leg fat percentage (left)	0.5	1.9	2.6	-1.6	-1.6	1.4	-0.8
Arm fat-free mass (left)	1.0	5.2	9.4	-2.2	-2.3	-1.1	-3.1
Number of operations (self-reported)	2.0	2.9	6.2	0.0	0.5	2.5	2.2
Average weekly beer plus cider intake	0.8	1.1	2.4	-1.5	-1.0	0.4	-1.0
Irritability	0.7	1.2	2.0	1.0	-1.4	1.0	-0.9
Risk taking	0.9	1.4	2.8	0.2	1.7	0.5	1.5
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.7	0.9	0.7	1.2	1.9
Fractured/broken bones in last 5 years	0.7	0.9	1.3	1.0	1.1	0.6	0.9
Age started oral contraceptive pill	2.2	2.8	5.9	-1.1	-2.4	1.4	-1.5
Diastolic blood pressure, automated reading	2.2	6.7	14.2	-0.0	-3.8	0.6	-3.5
Ever depressed for a whole week	0.4	0.6	1.1	1.0	0.6	0.2	0.8
Unable to work because of sickness or disability	0.4	0.6	1.3	0.6	-0.3	1.2	0.7
Commuting to job workplace: Cycle	2.9	3.5	9.4	0.6	2.0	-3.1	-0.7
Myopia	0.4	0.7	1.8	1.3	0.5	-0.6	0.4
Vascular/heart problems diagnosed by doctor	0.7	2.0	3.7	0.7	1.9	-1.9	0.3
Cholesterol lowering medication	0.2	0.3	0.7	-0.3	-0.5	0.9	0.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.4	-0.7	0.8	0.5	1.8
Pain experienced in last month	0.6	0.9	2.4	-0.6	0.8	-1.5	-0.6
Supplements: Calcium	0.2	0.2	0.5	0.3	0.1	-0.3	0.7
Basal cell carcinoma (self-reported)	0.7	0.8	2.4	0.3	0.7	-1.6	-0.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.0	-0.4	1.3	-1.1	1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.7	0.8	0.8	-0.9	-0.7
Heart disease (siblings)	1.9	2.4	4.7	-1.7	0.3	2.2	1.4
Alcohol drinker status: Previous	2.1	2.4	4.8	0.6	1.0	1.9	2.2
Pack years of smoking	0.3	0.4	1.0	-0.3	-1.0	0.8	0.0
Impedance of whole body	0.7	3.8	14.1	3.8	0.6	0.3	0.7
Leg fat mass (left)	0.8	3.2	4.9	-1.7	-2.2	1.2	-1.9
Arm predicted mass (left)	1.0	5.0	9.5	-1.9	-2.5	-0.9	-3.1