TWAS hub - EIF2D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.066	0.0260	3.8e-03	0.023	0.019	-0.002	0.020	0.005	7.6e-04	2.2e-03	8.9e-01	1.4e-03	7.1e-02
2	GTEx	Artery Tibial	0.210	0.0485	4.4e-06	0.125	NA	0.090	NA	0.105	5.0e-10	NA	1.6e-07	NA	1.4e-08
3	GTEx	Cells Transformed fibroblasts	0.177	0.0460	3.3e-05	0.092	NA	0.092	NA	0.100	2.0e-07	NA	2.2e-07	NA	6.0e-08
4	GTEx	Esophagus Muscularis	0.200	0.0640	1.3e-03	0.127	NA	0.084	NA	0.107	3.9e-08	NA	8.9e-06	NA	4.8e-07
5	GTEx	Lung	0.132	0.0437	1.4e-03	0.116	NA	0.110	NA	0.118	3.3e-09	NA	9.7e-09	NA	2.5e-09
6	GTEx	Nerve Tibial	0.134	0.0434	4.0e-04	0.128	NA	0.093	NA	0.106	2.3e-09	NA	4.3e-07	NA	6.0e-08
7	METSIM	Adipose	0.134	0.0318	1.9e-08	0.071	0.078	0.082	0.088	0.088	8.2e-11	1.1e-11	2.7e-12	3.8e-13	3.8e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Asthma (self-reported)	4.5	9.0	9.7	-3.1	-3.1	-3.0	-3.0	-3.0	-3.0	-2.8
Had other major operations	4.3	5.3	10.6	-3.3	-2.3	-2.0	-2.1	-2.3	-2.1	-1.8
Asthma	4.0	7.9	9.7	-3.1	-2.9	-2.8	-2.8	-2.8	-2.8	-2.5
Ovarian Cancer	3.3	4.4	8.2	-0.2	2.2	2.2	2.0	2.2	2.0	2.9
Mood swings	3.3	6.0	7.5	-2.3	-2.5	-2.5	-2.5	-2.7	-2.5	-2.0
Age at first live birth	3.0	5.3	9.3	-0.9	-2.3	-2.2	-2.4	-2.3	-2.4	-3.1
High cholesterol (Self-reported)	3.0	5.3	6.9	-2.5	-2.1	-2.6	-2.3	-2.3	-2.3	-1.8
Rheumatoid Arthritis	2.9	3.9	8.5	-2.9	-1.9	-1.7	-2.0	-1.8	-2.1	-0.8
Respiratory disease	2.9	6.5	9.6	-3.1	-2.5	-2.6	-2.5	-2.6	-2.5	-2.0
Age started oral contraceptive pill	2.9	3.6	4.2	-1.8	-1.9	-2.0	-1.9	-2.1	-1.9	-1.8
Migraine (self-reported)	2.8	3.5	4.7	-0.9	-2.0	-2.2	-2.1	-2.0	-2.1	-1.4
Relative age voice broke	2.7	4.1	5.1	1.9	2.2	2.3	2.1	2.1	2.1	1.4
Medication: Seretide 50 evohaler	2.7	3.1	4.5	-1.9	-1.5	-2.1	-1.8	-1.6	-1.8	-1.6
Type 2 Diabetes (T2D) (2018)	2.6	4.8	5.8	-2.4	-2.3	-2.4	-2.2	-2.4	-2.2	-1.3
Eye problems/disorders: Glaucoma	2.6	3.1	4.0	-0.4	-1.8	-2.0	-2.0	-1.9	-2.0	-1.5
Wheeze or whistling in the chest in last year	2.5	4.5	8.1	-2.8	-2.0	-2.2	-1.9	-2.0	-1.9	-1.9
Family relationship satisfaction	2.5	3.0	4.1	0.4	1.9	1.7	1.9	1.7	1.9	2.0
Taking other prescription medications	2.4	3.7	8.4	-2.9	-1.9	-1.7	-1.7	-2.0	-1.8	-0.9
Diabetes diagnosed by doctor	2.4	4.0	9.0	-3.0	-1.8	-2.1	-1.8	-1.9	-1.9	-0.8
Alcohol drinker status: Never	2.3	2.8	3.2	1.0	1.8	1.8	1.8	1.8	1.8	1.7
Gout (self-reported)	2.2	3.1	4.2	-0.0	-2.0	-1.7	-2.0	-2.1	-2.0	-1.4
Blood White Count	2.0	14.8	28.3	-1.4	-3.3	-4.2	-3.8	-4.0	-3.7	-5.3
Headache pain in last month	2.0	3.5	4.4	-1.6	-1.9	-2.1	-1.8	-2.0	-1.9	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.5	-1.1	-1.4	-1.6	-1.5	-1.6	-1.6	-1.9
Neuroticism	1.9	4.5	5.8	-2.3	-1.9	-2.4	-1.9	-2.1	-2.0	-2.3
Medication for hormone replacement therapy	1.9	2.1	3.2	-0.9	-1.8	-1.4	-1.6	-1.6	-1.6	-0.9
Number of children fathered	1.9	2.1	3.1	-1.8	-1.6	-1.3	-1.4	-1.7	-1.4	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	2.9	0.2	1.7	1.5	1.6	1.7	1.6	1.4
Long-standing illness, disability or infirmity	1.9	2.9	5.5	-2.4	-1.8	-1.6	-1.6	-1.8	-1.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	2.4	1.5	1.1	1.6	1.5	1.3	1.5	1.4
Number of self-reported non-cancer illnesses	1.9	3.3	6.7	-2.6	-1.8	-1.7	-1.8	-1.9	-1.8	-0.6
Age when periods started (menarche)	1.8	4.4	9.2	-0.5	-1.9	-2.1	-2.0	-2.2	-2.1	-3.0
Allergy	1.8	4.1	5.6	2.4	2.3	1.9	2.0	2.1	2.0	1.2
Glaucoma (self-reported)	1.8	2.2	2.7	-1.0	-1.6	-1.6	-1.6	-1.6	-1.6	-1.0
Commuting to job workplace: Walk	1.8	1.9	2.5	-1.2	-1.4	-1.4	-1.5	-1.6	-1.5	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	9.6	-3.1	1.3	1.1	1.4	1.4	1.4	1.4
Ever depressed for a whole week	1.8	2.2	4.6	2.1	1.2	1.3	1.3	1.2	1.3	1.8
Medication: Metformin	1.6	2.3	6.9	-2.6	-1.4	-1.4	-1.2	-1.4	-1.3	-0.1
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.3	0.7	-1.3	-1.5	-1.5	-1.4	-1.5	-1.3
Lupus	1.5	2.3	3.0	0.7	1.7	1.6	1.7	1.6	1.7	1.3
Sensitivity / hurt feelings	1.5	2.5	3.6	0.4	1.8	1.4	1.7	1.9	1.8	1.5
Breast cancer (self-reported)	1.5	1.8	2.5	-0.4	1.5	1.4	1.6	1.4	1.6	1.2
Body Mass Index (BMI) (2010)	1.4	2.0	6.2	-2.5	-1.2	-1.2	-1.1	-1.2	-1.1	-0.7
Hearing difficulty/problems: Yes	1.4	2.1	3.8	0.1	-1.9	-1.4	-1.6	-1.6	-1.6	-1.3
Relative age of first facial hair	1.4	3.0	4.4	0.8	2.1	1.8	1.9	1.9	1.9	1.1
Qualifications: CSEs or equivalent	1.4	1.9	2.4	-1.5	-1.4	-1.4	-1.3	-1.6	-1.3	-1.1
Diabetes (self-reported)	1.4	2.2	3.3	-1.8	-1.5	-1.6	-1.4	-1.6	-1.5	-0.6
Pulse wave Arterial Stiffness index	1.4	1.7	1.9	-1.2	-1.2	-1.2	-1.3	-1.4	-1.4	-1.3
Birth weight	1.4	3.1	4.4	-2.1	-1.7	-1.9	-1.6	-1.9	-1.6	-1.3
Ever had bowel cancer screening	1.4	1.6	2.3	0.3	1.4	1.2	1.5	1.3	1.4	1.4
Allergy or Eczema	1.3	3.3	4.4	-1.9	-2.1	-1.9	-1.8	-1.8	-1.9	-1.2
Alcohol usually taken with meals	1.3	2.0	2.9	-1.7	-1.6	-1.7	-1.4	-1.3	-1.4	-0.5
Hair/balding pattern: Pattern 2	1.3	1.6	3.3	0.9	1.0	1.5	1.1	1.2	1.2	1.8
Illnesses of siblings	1.3	1.8	5.6	2.4	1.0	1.2	0.8	1.3	0.9	0.9
Number of operations (self-reported)	1.3	1.9	4.9	-2.2	-1.4	-1.1	-1.1	-1.4	-1.1	-0.9
Risk taking	1.3	1.9	3.1	-0.7	-1.8	-1.4	-1.4	-1.5	-1.4	-1.3
Number of treatments/medications taken	1.2	2.2	3.0	-1.2	-1.6	-1.7	-1.6	-1.6	-1.6	-0.7
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.2	-0.8	-0.9	-1.4	-1.2	-1.2	-1.2	-2.0
Hayfever, allergic rhinitis or eczema	1.2	2.5	3.8	-1.5	-1.9	-1.5	-1.6	-1.6	-1.6	-1.0
Noisy workplace	1.2	1.5	2.1	-1.4	-1.3	-1.1	-1.3	-1.3	-1.3	-0.8
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.9	-1.7	-1.3	-1.2	-1.3	-1.0	-1.2	-1.0
Average weekly champagne plus white wine intake	1.2	1.7	3.8	2.0	1.2	1.2	1.3	1.2	1.3	0.5
Average weekly beer plus cider intake	1.2	1.8	4.1	2.0	1.4	1.4	1.2	1.3	1.2	0.1
Diastolic blood pressure, automated reading	1.2	3.8	7.4	0.8	2.7	1.9	2.2	2.0	2.2	1.0
Depressed Affect (Nagel 2018)	1.1	2.4	3.2	-1.2	-1.6	-1.8	-1.6	-1.6	-1.6	-1.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.4	1.0	1.1	1.6	1.0	1.3	1.0	1.4
Mouth/teeth dental problems: Dentures	1.1	1.9	3.9	-0.4	-1.1	-2.0	-1.4	-1.4	-1.5	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.0	-0.6	-1.4	-1.1	-1.3	-1.3	-1.3	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	8.9	-3.0	0.0	-0.5	-0.2	0.0	-0.3	0.4
Stomach or abdominal pain in last month	1.0	1.3	1.8	-1.0	-1.2	-1.2	-1.0	-1.2	-1.0	-1.3
Neuroticism score	1.0	2.1	2.9	-1.7	-1.1	-1.7	-1.3	-1.3	-1.3	-1.7
Worrier / anxious feelings	1.0	1.9	2.7	-1.0	-1.1	-1.5	-1.4	-1.5	-1.4	-1.6
High blood pressure (siblings)	1.0	1.4	2.2	-1.3	-1.0	-1.5	-0.8	-1.4	-0.8	-1.3
Pulse wave peak to peak time	1.0	1.2	1.6	0.9	1.1	1.1	1.1	1.1	1.2	1.3
Miserableness	1.0	1.7	3.3	-0.8	-1.0	-1.6	-1.2	-1.2	-1.3	-1.8
Blood Eosinophil Count	0.9	7.1	25.0	-5.0	-2.2	-2.0	-2.5	-2.0	-2.4	-0.6
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	3.2	-1.5	0.4	0.6	0.4	0.3	0.5	1.8
Impedance of leg (right)	0.9	4.6	5.5	2.2	2.3	2.1	2.3	2.1	2.3	1.4
Current tobacco smoking	0.9	1.5	1.8	-1.2	-1.3	-1.3	-1.1	-1.2	-1.1	-1.2
Number of incorrect matches in round	0.9	1.6	2.4	-1.2	-1.3	-1.5	-1.3	-1.0	-1.4	-0.9
Qualifications: None of the above	0.9	2.0	3.3	0.6	1.6	1.5	1.4	1.8	1.3	1.4
Lung cancer (father)	0.9	1.1	2.6	-0.5	0.9	1.1	1.0	0.9	1.0	1.6
Overall health rating	0.9	1.9	4.3	-2.1	-1.2	-1.6	-1.2	-1.3	-1.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	3.0	1.7	1.4	1.4	1.5	1.4	1.5	0.7
Worry (Nagel 2018)	0.8	1.7	2.4	-0.8	-1.1	-1.5	-1.3	-1.5	-1.3	-1.4
Medication: Ramipril	0.8	1.0	1.7	0.3	-1.1	-1.2	-1.0	-1.3	-1.0	-0.7
Impedance of arm (right)	0.8	3.6	6.4	2.5	1.8	1.7	2.0	1.9	1.9	1.2
Number of full sisters	0.8	1.0	1.6	-1.3	-0.9	-1.0	-0.9	-0.9	-0.9	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.1	-0.4	0.9	0.8	1.0	0.9	1.0	1.4
Medication: Aspirin	0.8	1.0	1.3	-0.4	1.2	1.0	1.1	0.9	1.1	1.2
Smoking status: Current	0.8	1.3	1.6	-0.9	-1.2	-1.2	-1.0	-1.2	-1.1	-1.3
Neuroticism (Nagel 2018)	0.7	1.8	2.1	-1.4	-1.2	-1.3	-1.2	-1.4	-1.2	-1.4
Crohns Disease (2012)	0.7	1.1	3.6	1.9	-0.8	-0.6	-0.8	-0.5	-0.8	-1.2
Neuroticism (2016)	0.7	1.0	1.6	1.1	1.3	0.7	1.1	1.1	1.1	0.4
Triglycerides	0.7	1.2	1.5	-1.2	-1.1	-1.2	-0.9	-1.2	-0.9	-1.1
Smoking Status	0.7	1.8	2.6	-1.6	-1.4	-1.3	-1.2	-1.2	-1.3	-1.3
Hand grip strength (right)	0.7	1.9	2.8	-0.4	-1.4	-1.4	-1.6	-1.7	-1.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	1.9	1.1	1.4	1.4	1.3	1.4	1.4	0.7
Medication: Atenolol	0.7	0.9	2.8	-1.7	-0.5	-0.8	-0.8	-0.9	-0.8	-0.8
Chronic bronchitis/emphysema (father)	0.7	0.8	1.6	-0.0	0.9	0.9	0.8	1.0	0.9	1.3
Medication: Simvastatin	0.7	1.0	1.8	-1.3	-0.9	-1.0	-1.0	-1.0	-1.0	-0.6
Number of live births	0.7	0.9	1.4	-0.4	1.1	1.1	1.0	1.2	1.0	0.6
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.4	-1.1	-0.6	-0.8	-1.0	-0.9	-1.2
Medication: Omeprazole	0.7	0.8	4.9	-2.2	-0.1	-0.7	-0.3	-0.0	-0.4	0.2
Chest pain or discomfort	0.7	0.9	1.2	1.0	-1.0	-1.0	-0.9	-1.1	-0.9	-0.8
Medication: Aspirin	0.7	0.9	1.3	-0.6	1.1	0.9	1.0	0.8	1.0	1.1
Osteoporosis (self-reported)	0.7	0.9	2.3	-1.2	0.5	1.0	0.7	0.5	0.7	1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	-1.3	-0.8	-0.7	-0.7	-0.8	-0.6	-1.0
Medication: Paracetamol	0.7	1.0	1.7	-1.3	-0.9	-1.1	-0.8	-0.8	-0.8	-1.1
Commuting to job workplace: Cycle	0.7	0.8	2.2	1.5	0.6	0.9	0.8	0.7	0.9	0.6
Depression (Nagel 2018)	0.6	0.9	1.6	-1.2	-0.6	-0.9	-0.8	-0.9	-0.8	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	-1.5	-0.8	-0.5	-0.5	-0.8	-0.6	0.4
Mean Putamen Volume	0.6	0.6	3.1	1.8	0.1	0.7	0.2	0.4	0.2	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	-1.2	-1.0	-0.8	-0.9	-1.0	-0.9	-0.3
Maternal smoking around birth	0.6	0.9	1.1	-0.9	-1.0	-1.0	-0.9	-1.1	-1.0	-0.5
Multivitamins +/- minerals	0.6	0.8	1.0	1.0	0.7	0.9	0.8	0.8	0.9	1.0
Father’s age at death	0.6	0.7	2.1	-0.2	-0.5	-1.1	-0.9	-0.5	-0.9	-1.4
Prospective memory result	0.6	0.8	1.2	-0.1	-1.1	-0.8	-1.1	-1.0	-1.0	-0.5
Medication: Paracetamol	0.6	0.9	1.2	-0.8	-1.1	-0.9	-1.0	-1.0	-1.0	-1.0
Arm fat-free mass (right)	0.6	3.1	4.9	-2.2	-1.6	-1.5	-1.8	-1.9	-1.8	-1.3
Worry too long after embarrassment	0.6	1.0	1.9	-1.4	-0.9	-1.0	-0.8	-1.0	-0.8	-1.2
Emphysema/chronic bronchitis	0.6	0.7	3.6	-1.9	-0.6	-0.5	-0.4	-0.5	-0.5	0.0
Medication: Ibuprofen	0.6	0.7	0.9	-0.5	-0.9	-1.0	-0.8	-0.8	-0.8	-0.9
Arm predicted mass (right)	0.6	3.3	5.2	-2.3	-1.6	-1.6	-1.9	-1.9	-1.8	-1.5
Medication for cholesterol	0.6	1.0	1.4	1.1	0.9	1.2	1.0	1.1	1.1	0.4
Wears glasses or contact lenses	0.6	0.7	1.3	-0.1	-0.9	-0.8	-0.9	-0.7	-0.9	-1.1
Medication: Bendroflumethiazide	0.6	0.9	3.8	2.0	0.8	0.8	0.6	0.7	0.7	0.4
Illnesses of father: High blood pressure	0.6	0.7	1.4	1.2	-0.4	-0.7	-0.7	-0.8	-0.7	-1.1
Ever smoked	0.6	1.0	1.4	-0.8	-1.1	-1.2	-1.0	-0.9	-1.1	-0.8
Myopia	0.6	0.8	1.4	-0.4	1.1	0.7	1.2	0.8	1.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.1	0.4	-1.0	-0.9	-0.9	-1.0	-0.9	-0.8
Impedance of whole body	0.6	3.1	3.9	2.0	1.8	1.6	1.9	1.8	1.9	0.9
Chronotype (morning person)	0.5	1.1	1.8	1.4	1.1	1.0	0.9	1.1	0.9	0.7
Fed-up feelings	0.5	1.0	3.2	-0.0	-0.6	-1.1	-0.8	-0.7	-0.8	-1.8
Impedance of leg (left)	0.5	2.4	3.0	1.6	1.7	1.6	1.7	1.6	1.7	0.8
Heart attack	0.5	0.7	2.1	-0.3	0.8	0.7	0.8	0.7	0.7	1.4
Trunk fat-free mass	0.5	3.0	4.1	-1.6	-1.7	-1.5	-1.9	-2.0	-1.8	-1.4
Impedance of arm (left)	0.5	2.4	4.3	2.1	1.5	1.3	1.7	1.5	1.6	0.8
Trunk predicted mass	0.5	2.8	3.9	-1.5	-1.6	-1.5	-1.8	-2.0	-1.8	-1.4
Blood clot in the leg (DVT)	0.5	0.6	0.9	0.2	-0.9	-0.8	-0.8	-1.0	-0.8	-0.8
Whole body fat-free mass	0.5	2.6	3.5	-1.6	-1.6	-1.4	-1.7	-1.9	-1.7	-1.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-0.1	-1.1	-0.6	-1.0	-1.0	-0.9	0.2
Cholesterol lowering medication	0.5	0.8	1.6	-1.3	-0.7	-1.0	-0.8	-0.9	-0.9	-0.6
Arm predicted mass (left)	0.5	2.3	3.3	-1.8	-1.4	-1.3	-1.6	-1.7	-1.6	-1.2
Major Depression (MDD)	0.4	0.5	1.6	0.5	0.6	0.6	0.7	0.5	0.7	1.3
Age at First Birth	0.4	0.5	0.6	0.5	-0.8	-0.8	-0.8	-0.8	-0.8	-0.6
HbA1C	0.4	0.5	1.9	-0.1	0.5	1.4	0.6	0.6	0.6	0.5
LDL Cholesterol	0.4	0.6	1.2	-1.1	-0.7	-0.8	-0.5	-0.6	-0.5	-0.9
Diabetes (father)	0.4	0.5	2.7	-1.7	-0.3	-0.5	-0.2	-0.4	-0.2	-0.4
Severe depression (siblings)	0.4	0.4	1.7	1.3	-0.0	-0.4	-0.3	0.1	-0.3	-1.0
Average weekly fortified wine intake	0.4	0.5	2.4	1.6	-0.5	-0.2	-0.4	-0.4	-0.5	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.7	-1.3	-0.4	0.3	-0.1	-0.2	0.0	0.9
Serious illness, injury or assault to yourself	0.4	0.5	0.8	-0.9	-0.8	-0.8	-0.5	-0.8	-0.6	-0.5
Had menopause	0.4	0.5	2.5	-1.6	-0.5	-0.4	-0.4	-0.2	-0.4	0.4
Hair/balding pattern: Pattern 3	0.4	0.7	0.9	-0.8	-0.6	-1.0	-0.7	-0.9	-0.7	-0.9
Medication: Lansoprazole	0.4	0.5	1.0	-0.1	0.7	0.5	1.0	0.6	0.9	0.7
Length of working week for main job	0.4	0.4	0.9	0.7	0.2	1.0	0.4	0.3	0.5	0.9
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	-0.9	0.7	0.3	0.6	0.6	0.5	0.8
Health satisfaction	0.4	0.6	0.9	-0.9	-0.7	-0.9	-0.6	-0.7	-0.7	-0.6
Eye problems/disorders: None of the above	0.4	0.4	0.7	0.8	0.7	0.5	0.8	0.7	0.8	0.2
Neck or shoulder pain in last month	0.4	0.6	0.9	-0.5	1.0	0.7	0.9	0.9	0.9	0.6
Medication: Allopurinol	0.4	0.5	1.1	0.2	-1.1	-0.6	-0.8	-1.0	-0.8	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.2	0.9	1.0	1.1	0.9	0.8	0.9	0.9
Leg fat-free mass (right)	0.4	2.1	2.7	-1.4	-1.4	-1.4	-1.6	-1.6	-1.5	-1.2
Qualifications: nursing, teaching	0.4	0.6	1.2	-0.7	-0.8	-0.6	-0.8	-1.1	-0.7	-0.8
Whole body water mass	0.4	2.3	3.2	-1.5	-1.4	-1.3	-1.6	-1.8	-1.6	-1.2
Leg predicted mass (right)	0.4	2.2	2.8	-1.4	-1.5	-1.4	-1.6	-1.7	-1.6	-1.2
Ever taken oral contraceptive pill	0.4	0.4	0.6	0.1	0.7	0.7	0.8	0.8	0.7	0.6
Arm fat-free mass (left)	0.4	2.1	2.9	-1.7	-1.3	-1.2	-1.6	-1.6	-1.5	-1.2
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.9	-0.3	0.6	0.6	0.7	0.6	0.6	1.4
Reaction Time	0.3	0.7	1.4	-0.1	-1.2	-0.7	-1.0	-0.8	-1.0	0.2
Ulcerative Colitis	0.3	0.4	2.2	1.5	-0.2	0.0	-0.2	-0.0	-0.3	-0.7
Hand grip strength (left)	0.3	0.8	1.3	-0.2	-1.0	-0.8	-1.0	-1.1	-1.0	-0.8
Medication: Co-codamol	0.3	0.4	1.4	-1.2	-0.5	-0.3	-0.4	-0.4	-0.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.3	-0.4	-0.3	-0.8	-0.3	-0.6	-0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	1.2	0.7	1.0	0.7	0.9	0.8	0.4
Medication: Cholesterol lowering	0.3	0.5	2.4	-1.5	-0.3	-0.5	-0.4	-0.7	-0.4	0.3
Breastfed as a baby	0.3	0.4	1.3	-1.1	-0.6	-0.4	-0.3	-0.6	-0.3	-0.4
Medication: Amlodipine	0.3	0.4	0.6	0.4	-0.7	-0.6	-0.8	-0.6	-0.8	-0.3
Shortness of breath walking on level ground	0.3	0.4	2.0	-1.4	-0.2	-0.5	-0.3	-0.1	-0.3	-0.1
Medication: Blood pressure	0.3	0.4	1.9	0.8	0.4	0.5	0.2	0.3	0.2	1.4
Pulse rate, automated reading	0.3	0.9	6.2	2.5	-0.1	0.1	-0.3	-0.2	-0.3	-0.1
Age at last live birth	0.3	0.5	1.2	-1.1	-0.4	-0.4	-0.4	-0.5	-0.4	-1.1
Knee pain experienced in last month	0.3	0.5	1.3	1.1	0.7	0.6	0.7	0.7	0.6	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-0.1	0.4	0.7	0.5	0.7	0.5	1.0
Osteoarthritis (self-reported)	0.3	0.4	0.6	-0.6	-0.5	-0.6	-0.8	-0.3	-0.8	-0.8
Guilty feelings	0.3	0.5	2.6	-1.6	-0.1	-0.4	-0.1	-0.1	-0.2	-0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.4	0.6	0.6	0.4	0.7	0.6	0.6	0.6
Basal metabolic rate	0.3	1.8	2.4	-1.4	-1.2	-1.2	-1.4	-1.6	-1.4	-1.0
Supplements: Calcium	0.3	0.3	0.6	-0.7	-0.8	-0.3	-0.5	-0.5	-0.5	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.9	0.8	1.0	0.7	0.8	0.7	0.8	0.4
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.6	0.4	0.5	0.5	0.5	0.5	0.5
Schizophrenia (2014)	0.2	0.4	1.9	0.1	0.1	0.5	0.2	0.5	0.3	1.4
Blood Platelet Count	0.2	2.9	7.9	-0.5	-1.4	-1.6	-1.5	-1.7	-1.5	-2.8
Waist Hip Ratio (WHR)	0.2	0.7	1.1	1.0	1.0	0.7	1.1	0.6	1.1	0.3
Cardiovascular Disease	0.2	0.5	1.4	-0.6	-0.7	-0.7	-0.7	-1.2	-0.7	-0.3
Systolic blood pressure, automated reading	0.2	0.7	1.7	0.0	1.3	0.8	1.0	0.8	0.9	0.1
Vitamin and mineral supplements	0.2	0.3	0.9	0.1	-0.4	-0.4	-0.5	-0.4	-0.5	-0.9
Diabetes (mother)	0.2	0.3	1.6	-1.3	0.2	0.1	0.3	0.1	0.3	0.0
Leg fat-free mass (left)	0.2	1.2	1.7	-1.1	-1.0	-1.0	-1.2	-1.3	-1.2	-0.8
High blood pressure	0.2	0.5	0.8	-0.6	-0.6	-0.7	-0.8	-0.9	-0.8	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	1.0	-0.4	0.1	-0.1	-0.2	-0.1	0.5
High blood pressure (mother)	0.2	0.3	1.1	-0.4	-0.3	-0.6	-0.3	-0.5	-0.2	-1.1
Leg predicted mass (left)	0.2	1.3	1.9	-1.1	-1.1	-1.1	-1.3	-1.4	-1.2	-0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.1	-0.5	-0.6	-0.3	-0.4	-0.4	-0.6
Pain all over the body in last month	0.2	0.3	0.7	-0.8	0.3	0.1	0.6	0.3	0.5	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.9	0.5	0.1	0.6	0.4	0.5	0.0
Pulse rate	0.2	0.4	2.6	1.6	-0.2	0.2	-0.2	-0.0	-0.1	-0.0
Happiness	0.2	0.3	0.5	0.3	0.7	0.2	0.6	0.5	0.6	0.7
Illnesses of mother	0.2	0.2	0.6	0.8	-0.5	-0.3	-0.4	-0.3	-0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.9	-0.9	-0.1	-0.3	-0.1	-0.2	-0.2	0.8
Birth weight of first child	0.2	0.3	0.7	-0.5	-0.7	-0.2	-0.4	-0.6	-0.4	0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.8	0.1	0.5	0.5	0.3	0.4	0.1
Leg fat percentage (right)	0.2	0.7	1.4	0.3	1.2	0.8	1.0	0.9	0.9	0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.6	0.2	0.6	0.4	0.2	0.4	0.8
Comparative body size at age 10	0.2	0.6	2.0	-1.4	-0.6	-0.5	-0.7	-0.4	-0.7	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.1	0.5	0.4	0.5	0.5	0.5	0.8
Qualifications: College or University degree	0.2	0.5	3.1	1.8	0.0	0.0	0.0	-0.2	0.0	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.3	-0.5	-0.5	-0.4	-0.3	-0.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.2	0.7	0.5	0.6	0.5	0.5	0.2
Suffer from ‘nerves’	0.2	0.2	0.4	-0.4	-0.3	-0.7	-0.5	-0.5	-0.5	-0.5
Had major operations	0.2	0.2	0.3	-0.4	-0.3	-0.4	-0.3	-0.5	-0.3	-0.6
Hypertension (Self-reported)	0.2	0.5	0.9	-0.7	-0.6	-0.7	-0.8	-1.0	-0.8	-0.2
Illnesses of father: Heart disease	0.2	0.2	0.6	-0.5	0.5	0.1	0.4	0.4	0.4	-0.8
Illnesses of siblings: Diabetes	0.2	0.3	0.9	-0.9	-0.0	0.2	0.2	-0.0	0.2	0.9
Average weekly red wine intake	0.2	0.2	0.9	-0.9	-0.2	-0.4	-0.2	-0.5	-0.2	-0.4
Friendships satisfaction	0.2	0.2	1.4	-1.2	0.2	-0.4	0.1	-0.1	0.1	-0.3
Mineral and other dietary supplements	0.2	0.3	1.9	1.4	0.3	0.2	0.2	0.2	0.2	0.3
Hearing aid user	0.2	0.2	0.5	-0.1	-0.5	-0.7	-0.4	-0.5	-0.5	-0.2
Mother’s age at death	0.2	0.2	1.2	-1.1	-0.4	-0.3	-0.3	-0.2	-0.3	-0.1
Financial situation satisfaction	0.2	0.2	1.0	-0.2	-0.3	-0.6	-0.3	-0.2	-0.3	-1.0
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.2	0.4	0.6	0.6	0.4	0.6	0.6
Medication: Blood pressure	0.2	0.3	1.5	-1.2	-0.1	-0.7	-0.3	-0.3	-0.4	-0.2
Medication: Lisinopril	0.2	0.2	0.3	-0.4	-0.6	-0.2	-0.5	-0.3	-0.5	0.5
Irritability	0.2	0.3	1.8	-1.3	-0.1	0.0	-0.0	-0.3	0.0	-0.0
Unable to work because of sickness or disability	0.2	0.3	1.4	-1.2	0.3	-0.1	0.3	0.2	0.3	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.8	0.7	0.6	0.7	0.8	0.9	0.8	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.0	0.5	0.5	0.5	0.7	0.6	0.1
Alcohol drinker status: Previous	0.2	0.3	0.4	-0.3	0.5	0.7	0.5	0.5	0.5	0.7
Bipolar Disorder (2018)	0.1	0.2	1.0	1.0	-0.4	0.1	-0.2	0.2	-0.1	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.5	-0.6	-0.1	-0.4	-0.0	-0.3	0.8
Schizophrenia (2018)	0.1	0.2	0.6	-0.2	-0.5	-0.2	-0.3	-0.1	-0.3	0.8
Schizophrenia vs Biploar Disorder	0.1	0.2	1.1	-1.0	0.0	-0.1	0.2	-0.2	0.2	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.2	-0.2	-0.5	-0.3	-0.3	-0.3	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.5	-0.3	-0.2	0.0	-0.3	-0.0	0.6
Crohns Disease (2017)	0.1	0.3	2.0	1.4	-0.2	0.4	-0.1	-0.1	-0.0	0.0
Irritable Bowel Disease (IBD)	0.1	0.3	2.1	1.4	-0.2	0.4	-0.1	0.0	-0.0	-0.4
Prostate Cancer	0.1	0.1	0.6	-0.8	-0.3	0.1	0.0	0.1	0.0	0.3
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	-0.3	-0.1	-0.2	0.0	-0.1	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.1	-0.4	0.4	0.1	0.3	0.3	0.3	-0.0
Fasting Glucose	0.1	0.1	0.3	0.1	0.4	-0.3	0.5	0.6	0.4	-0.3
HDL Cholesterol	0.1	0.2	1.0	1.0	-0.2	-0.1	-0.1	-0.1	-0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.7	-0.8	-0.1	-0.2	-0.1	-0.1	-0.1	-0.1
Blood Red Count	0.1	0.9	6.2	-2.5	0.2	0.3	0.1	0.2	0.2	0.2
Height	0.1	1.1	2.3	0.1	-0.8	-1.2	-1.1	-1.5	-1.0	-0.8
Systolic Blood Pressure	0.1	0.4	0.8	-0.7	-0.1	-0.4	-0.3	-0.9	-0.4	-0.9
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.3	-0.6	-0.5	-0.6	-0.7	-0.7	0.1
Lung FVC	0.1	0.5	1.2	-0.1	-1.1	-0.8	-0.7	-0.9	-0.7	-0.6
Average weekly spirits intake	0.1	0.1	0.7	0.8	0.3	0.0	0.2	0.1	0.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	1.1	-1.0	-0.2	-0.0	-0.1	-0.0	-0.2	0.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.6	-0.5	-0.2	-0.1	-0.3	-0.1	0.1
Supplements: Zinc	0.1	0.1	0.3	0.5	-0.2	-0.2	-0.2	-0.4	-0.2	-0.5
Pack years adult smoking proportion	0.1	0.2	0.5	0.7	0.5	0.2	0.3	0.3	0.3	-0.4
Trunk fat percentage	0.1	0.3	0.6	0.3	0.8	0.5	0.7	0.5	0.6	0.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.1	0.3	0.5	0.6	0.4	0.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	-0.7	0.0	-0.5	-0.1	-0.2	-0.2	-0.8
Supplements: Glucosamine	0.1	0.2	0.8	-0.9	-0.1	0.1	0.1	-0.1	0.1	-0.5
Medication: Levothyroxine sodium	0.1	0.3	1.1	0.6	0.2	0.3	0.2	0.1	0.2	1.1
Sitting height	0.1	0.4	1.1	1.1	-0.5	-0.0	-0.7	-0.6	-0.6	0.3
Past tobacco smoking	0.1	0.2	1.1	1.1	0.1	0.4	0.1	0.1	0.2	0.2
Nervous feelings	0.1	0.1	0.4	-0.7	0.2	-0.3	-0.2	-0.1	-0.2	-0.4
Mouth/teeth dental problems	0.1	0.2	1.1	1.0	-0.1	0.4	-0.1	-0.1	-0.0	0.2
Fluid intelligence score	0.1	0.1	0.7	0.8	0.1	0.1	-0.0	-0.3	0.0	-0.3
Weight	0.1	0.5	0.9	-1.0	-0.4	-0.7	-0.7	-0.8	-0.7	-0.6
Arm fat percentage (right)	0.1	0.3	0.5	0.5	0.7	0.5	0.6	0.5	0.6	0.4
Time employed in main current job	0.1	0.1	0.3	0.5	0.1	-0.1	-0.1	-0.0	-0.0	-0.4
Falls in the last year	0.1	0.2	0.7	-0.3	-0.4	-0.3	-0.1	-0.3	-0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	0.2	-0.1	-0.3	-0.2	-0.6	-0.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	0.5	0.3	0.6	0.4	0.3	0.3	0.3
Depression (self-reported)	0.1	0.2	0.4	-0.7	-0.2	-0.3	-0.1	-0.3	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.9	1.4	0.2	0.3	0.3	0.1	0.3	0.1
Standing height	0.1	1.2	2.4	-0.4	-1.0	-1.1	-1.2	-1.5	-1.1	-1.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	-0.9	-0.3	-0.5	-0.4	-0.2	-0.4	-0.7
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.3	-0.6	-0.3	-0.5	-0.5	-0.4	-0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	0.0	-0.0	-0.1	-0.2	0.1	-0.1	0.6
Loud music exposure frequency	0.1	0.1	0.3	-0.2	-0.5	-0.1	-0.3	-0.5	-0.3	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.7	0.4	-0.0	-0.0	0.1	0.3	0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.2	-0.4	-0.4	-0.5	-0.6	-0.6	0.3
Body fat percentage	0.1	0.4	0.7	0.3	0.8	0.6	0.7	0.6	0.7	0.4
Medication for pain relief, constipation, heartburn	0.1	0.1	0.5	0.5	-0.2	-0.1	-0.2	-0.3	-0.2	-0.7
Angina (self-reported)	0.1	0.1	0.2	0.0	-0.5	-0.2	-0.3	-0.3	-0.4	-0.1
Mean time to correctly identify matches	0.1	0.3	0.5	-0.2	-0.7	-0.4	-0.5	-0.3	-0.6	0.5
Alcohol intake frequency.	0.1	0.3	1.4	-1.2	0.3	0.2	0.2	0.2	0.1	0.8
Comparative height size at age 10	0.1	0.7	1.7	-0.7	-0.9	-0.6	-0.9	-1.3	-0.8	-0.1
Leg pain on walking	0.1	0.1	0.3	0.3	0.4	0.5	0.4	0.4	0.4	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.4	0.4	0.3	0.3	0.3	0.3	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.3	-0.1	-0.2	-0.3	-0.1	-0.3	-0.6
Supplements: Vitamin C	0.1	0.1	0.2	-0.1	0.4	0.3	0.4	0.4	0.3	0.2
Smoking status: Previous	0.1	0.1	0.7	-0.8	0.2	0.0	0.2	0.2	0.1	0.1
Loneliness, isolation	0.1	0.1	0.4	0.0	-0.4	-0.6	-0.3	-0.2	-0.4	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.5	0.3	0.1	-0.0	0.1	0.0	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.4	0.2	0.2	0.4	0.3	0.4	0.5
Back pain experienced in last month	0.1	0.1	0.3	-0.5	0.4	0.2	0.3	0.3	0.3	-0.1
Medication: Gliclazide	0.1	0.1	0.3	-0.5	-0.0	-0.1	-0.0	-0.1	-0.1	0.3
Leg fat percentage (left)	0.1	0.4	0.9	-0.1	1.0	0.6	0.8	0.7	0.7	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.4	-0.5	-0.0	-0.4	-0.3	-0.3	-0.3
Pain experienced in last month	0.1	0.1	0.6	0.8	-0.3	0.4	-0.1	-0.1	-0.0	0.3
Heart disease (siblings)	0.1	0.2	0.5	-0.6	-0.1	-0.1	0.1	-0.4	-0.0	-0.7
Pack years of smoking	0.1	0.2	0.5	0.5	0.7	0.2	0.5	0.4	0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.2	0.3	-0.5	-0.3	-0.2	-0.3	-0.5	-0.3	-0.5
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.3	-0.4	-0.0	-0.3	-0.2	-0.3	-0.4
Breast Cancer	0.0	0.1	0.2	-0.4	-0.3	-0.2	-0.3	-0.3	-0.3	-0.2
Heel T-Score	0.0	0.3	1.4	1.2	-0.0	-0.2	-0.2	0.3	-0.2	-0.7
BMI	0.0	0.1	0.3	-0.2	0.2	0.0	-0.1	-0.0	-0.0	-0.6
Lung FEV1/FVC ratio	0.0	0.2	0.7	0.8	0.4	0.0	0.3	0.4	0.2	-0.0
Hair Pigment	0.0	0.6	0.9	-0.4	-0.9	-0.8	-0.8	-0.9	-0.8	-0.6
Tanning	0.0	0.3	1.3	1.2	0.6	0.1	0.4	0.5	0.4	-0.2
Angina	0.0	0.0	0.1	0.1	-0.3	-0.0	-0.2	-0.2	-0.2	0.1
Body mass index (BMI)	0.0	0.1	0.6	-0.8	-0.0	-0.3	-0.2	-0.2	-0.3	-0.2
Trunk fat mass	0.0	0.1	0.2	0.0	0.4	0.2	0.3	0.1	0.3	0.1
Waist circumference	0.0	0.1	0.3	0.2	0.5	0.3	0.4	0.2	0.4	0.2
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.2	0.2	0.1	0.4	0.3	0.3	-0.1
Forced vital capacity (FVC)	0.0	0.1	0.3	0.5	-0.3	-0.0	-0.2	-0.4	-0.1	0.0
Financial difficulties in last 2 years	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.0	0.0	-0.0	0.2
Hip circumference	0.0	0.1	0.2	0.1	0.4	0.3	0.3	0.2	0.3	0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.0	-0.1	-0.2	-0.0	-0.0	-0.0	0.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.9	1.0	-0.2	0.0	-0.1	-0.3	-0.0	-0.1
Arm fat mass (right)	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1	-0.1	-0.1	-0.0
Tense / ‘highly strung’	0.0	0.1	0.5	0.7	-0.1	-0.0	-0.1	-0.1	-0.1	0.0
Pulse wave reflection index	0.0	0.1	0.1	0.3	0.4	0.0	0.1	0.3	0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.2	-0.0	-0.3	-0.2	-0.4	-0.1	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.2	0.6	0.8	0.2	0.4	0.3	-0.0	0.3	0.2
Number of full brothers	0.0	0.0	0.1	-0.0	-0.0	0.1	0.2	0.0	0.2	0.3
Heart disease (mother)	0.0	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.2	-0.0
Whole body fat mass	0.0	0.0	0.1	-0.1	0.3	0.0	0.1	-0.0	0.1	-0.1
Leg fat mass (right)	0.0	0.2	0.5	-0.1	0.7	0.4	0.4	0.3	0.5	0.3
Arm fat percentage (left)	0.0	0.1	0.3	0.2	0.6	0.3	0.4	0.4	0.4	0.3
Arm fat mass (left)	0.0	0.0	0.2	-0.4	0.1	-0.1	-0.1	-0.2	-0.1	-0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.2	-0.4	0.2	-0.0	0.1	0.2	0.1	-0.2
Medication: Atorvastatin	0.0	0.1	0.1	0.2	0.1	-0.2	-0.1	-0.3	-0.1	0.4
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.0	-0.1	-0.0	0.1	-0.2	-0.0	-0.2
Leg fat mass (left)	0.0	0.1	0.4	-0.2	0.6	0.4	0.4	0.3	0.4	0.2

Hub : Genes

EIF2D

Models

Trait associations