Hub : Genes

PRR15L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0923 0.0411 3.7e-04 0.001 0.016 0.024 NA 0.004 0.16000 2.2e-04 9.6e-06 NA 3.9e-02
2 TCGA Colon Adenocarcinoma 0.1450 0.0590 1.4e-05 0.051 0.084 0.099 NA 0.101 0.00067 1.4e-05 2.4e-06 NA 2.0e-06
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.0410 0.0250 9.3e-03 0.023 0.035 0.036 NA 0.030 0.01700 4.1e-03 3.9e-03 NA 7.4e-03
4 TCGA Brain Lower Grade Glioma 0.0785 0.0337 1.4e-05 0.007 0.030 0.026 NA 0.024 0.05000 1.9e-04 5.8e-04 NA 8.2e-04
5 TCGA Lung Squamous Cell Carcinoma 0.0482 0.0284 7.2e-03 0.017 0.012 0.025 NA 0.027 0.00400 1.4e-02 7.0e-04 NA 3.9e-04
6 TCGA Prostate Adenocarcinoma 0.0343 0.0172 1.2e-04 0.017 0.033 0.032 NA 0.023 0.00590 2.0e-04 2.4e-04 NA 1.7e-03
7 TCGA Thyroid Carcinoma 0.0620 0.0320 4.5e-04 0.023 0.042 0.025 NA 0.021 0.00250 5.2e-05 1.5e-03 NA 3.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.5 2.4 4.1 -0.8 -1.5 -1.8 1.6 -2.0 -2.0 -0.0
Bipolar Disorder or Schizophrenia 0.6 1.4 4.2 -0.4 -0.9 -1.6 0.5 -1.4 -2.0 -0.1
Depressed Affect (Nagel 2018) 0.5 1.0 1.9 0.2 1.4 -0.1 -1.2 0.5 -1.3 1.2
Depression (Nagel 2018) 1.3 1.9 4.6 0.7 1.7 1.5 -2.1 1.2 0.5 1.3
Intelligence (Savage-Jansen 2018) 1.3 4.1 11.8 2.1 -0.2 3.4 -1.8 0.2 2.7 -1.3
Neuroticism (Nagel 2018) 0.5 1.1 4.8 -0.5 -0.1 -1.2 0.2 -0.9 -2.2 0.3
Schizophrenia (2018) 0.1 0.3 1.0 0.2 0.1 -0.6 -0.7 -0.2 -1.0 -0.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.2 0.8 0.4 1.0 -1.1 0.6 0.6 -0.2
Worry (Nagel 2018) 2.0 4.3 7.5 -2.2 -2.4 -1.5 1.8 -2.7 -2.3 -1.1
Alzheimer’s Disease (in mother) 0.4 0.4 1.2 -1.1 0.8 -0.6 -0.4 0.8 0.2 0.3
Alzheimer’s Disease (in father) 0.1 0.1 0.3 0.3 0.3 0.3 -0.3 0.3 -0.3 -0.5
Alzheimer’s Disease (including proxy) 0.4 0.5 1.8 -0.8 0.5 -1.3 0.1 0.5 -0.8 -0.1
Crohns Disease (2017) 2.4 5.2 10.3 -1.3 -2.9 -1.7 1.5 -2.9 -1.8 -3.2
Irritable Bowel Disease (IBD) 3.7 8.8 17.6 -0.7 -3.9 -1.2 1.8 -4.2 -2.7 -4.1
Ulcerative Colitis (UC) 3.1 5.9 12.6 -0.1 -3.2 -0.5 1.7 -3.5 -2.6 -2.9
Major Depression (MDD) 0.5 0.7 2.0 -0.7 0.3 0.9 -1.4 0.6 0.7 -0.6
Reaction Time 1.8 3.4 9.7 -0.5 -0.9 -2.6 3.1 -1.1 -2.0 0.9
Verbal and Numeric Reasoning (VNR) 2.2 5.2 14.6 3.0 0.6 3.8 -2.3 0.8 2.5 -0.8
Breast Cancer 0.6 1.5 4.6 2.1 0.8 -1.1 -1.7 0.9 -0.2 -0.1
Ovarian Cancer 10.5 13.8 27.9 -2.8 -3.1 -5.3 4.4 -1.8 -5.0 -2.2
Prostate Cancer 1.7 2.4 7.1 0.8 -0.8 2.7 -1.4 -0.1 1.0 -2.4
Age at First Birth 0.5 0.8 2.8 0.9 -0.4 1.7 -0.3 -0.9 0.6 -0.6
Bipolar Disorder (2011) 2.3 2.3 4.8 -1.0 -1.1 -2.0 2.2 -1.5 -1.5 0.3
Body Mass Index (BMI) (2010) 1.2 1.6 4.2 1.9 0.9 -1.0 -2.0 1.1 -0.6 -0.4
Coronary Artery Disease (CAD) 0.8 1.0 2.3 -1.4 -1.0 -0.4 1.5 -0.9 -0.9 -0.0
Crohns Disease (2012) 2.0 3.2 5.5 -1.2 -2.4 -1.4 1.9 -1.9 -1.1 -2.3
Mean Putamen Volume 0.5 0.6 2.2 -0.7 -0.7 0.3 -0.6 0.1 0.6 -1.5
Fasting Glucose 0.5 0.6 2.7 -1.6 -0.1 0.4 0.3 -0.2 1.0 -0.4
HbA1C 1.6 1.7 3.4 1.1 1.5 1.1 -0.4 0.9 1.8 1.8
HDL Cholesterol 1.9 3.2 8.4 -1.8 -2.9 -0.1 2.1 -1.5 -0.4 -1.8
LDL Cholesterol 1.6 2.6 3.9 -0.8 -1.9 -1.9 2.0 -1.7 -1.8 -0.7
Lupus 2.3 3.5 9.6 0.0 -2.7 0.2 3.1 -2.5 -0.5 -1.0
Neuroticism (2016) 0.4 0.5 0.9 0.8 0.5 -0.2 -1.0 0.5 -0.9 0.7
Primary Biliary Cirrhosis 3.5 5.0 11.2 -1.1 -2.7 -2.2 1.2 -1.8 -2.3 -3.3
Rheumatoid Arthritis 0.2 0.2 0.6 -0.2 0.4 0.5 -0.1 -0.1 0.7 0.6
Schizophrenia (2014) 0.2 0.4 1.3 0.0 0.1 -1.1 -0.4 -0.1 -1.0 0.5
Triglycerides 0.4 0.7 2.4 -0.6 1.0 -0.0 -1.6 0.6 0.8 0.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.5 -0.2 1.2 0.1 -1.6 -0.2 0.2 -0.9
Ulcerative Colitis 2.0 2.9 6.3 0.2 -2.5 0.2 1.2 -2.4 -1.2 -2.3
Blood Eosinophil Count 0.7 5.5 14.2 -0.1 1.6 3.4 -1.2 1.3 3.8 2.6
Blood Platelet Count 0.7 8.3 22.0 0.6 -0.2 4.7 -4.5 -0.8 1.8 -3.4
Blood Red Count 5.1 49.3 112.4 -3.1 -6.0 -10.1 6.6 -5.3 -10.6 -3.7
Blood White Count 4.2 31.0 57.2 4.1 6.6 6.0 -7.6 4.8 5.4 3.2
Heel T-Score 2.6 20.5 42.5 1.5 6.5 0.6 -4.6 4.8 3.5 6.5
BMI 1.4 8.0 22.7 1.7 3.7 -0.7 -4.8 3.6 -1.1 1.5
Height 1.0 20.2 64.5 -1.9 -6.5 4.4 -0.4 -3.3 -1.0 -8.0
Waist Hip Ratio (WHR) 0.4 1.9 7.6 -0.2 -0.4 -2.8 0.6 -1.1 -1.4 -1.4
Systolic Blood Pressure 1.3 6.3 15.0 0.7 2.9 3.9 -3.1 0.6 2.9 1.3
Smoking Status 2.8 6.8 15.7 1.3 4.0 0.4 -3.1 3.0 1.1 3.2
Allergy or Eczema 0.6 1.5 3.8 0.4 1.4 1.1 -0.3 2.0 0.8 1.6
Cardiovascular Disease 0.8 2.5 6.2 -0.6 -0.9 -1.9 0.6 -1.9 -2.5 -1.7
Hypothyroidism (self reported) 1.5 3.4 10.2 -2.1 -1.5 -3.2 1.9 -0.5 -1.4 -1.1
Respiratory disease 0.3 0.6 1.5 -1.1 -0.8 0.2 1.2 -0.9 -0.2 -0.0
Type 2 Diabetes (T2D) (2018) 1.4 2.6 4.2 1.9 2.0 0.9 -1.7 1.5 1.7 1.2
Lung FEV1/FVC ratio 4.1 20.9 37.6 3.8 6.1 1.6 -4.5 5.0 4.2 5.3
Lung FVC 1.8 9.2 42.8 -1.6 -2.2 -1.4 6.5 -2.5 -1.7 1.8
Neuroticism 0.5 1.2 5.3 -0.3 -0.5 -1.2 0.2 -1.0 -2.3 -0.3
Chronotype (morning person) 1.6 3.6 14.7 -0.5 -0.3 -3.8 2.1 0.8 -2.2 0.7
Hair Pigment 5.8 165.1 436.8 1.2 16.1 -1.4 -1.0 20.9 11.6 17.9
Tanning 0.3 3.1 6.4 -0.7 -2.3 -0.1 0.7 -1.9 -2.5 -2.4
Hand grip strength (left) 2.6 6.8 17.2 -0.9 -2.1 -3.3 4.1 -1.4 -3.6 0.0
Number of treatments/medications taken 1.1 2.0 5.8 -0.5 -1.0 -1.7 0.1 -0.6 -1.8 -2.4
Average weekly spirits intake 0.9 1.1 3.8 -0.6 0.7 -1.9 0.0 1.3 -0.9 0.8
Sensitivity / hurt feelings 0.8 1.4 3.4 0.1 1.3 -1.9 0.5 0.2 -1.1 1.6
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.4 1.1 0.5 -0.1 -1.2 0.5 -0.9 0.1
Hearing difficulty/problems: Yes 1.2 1.8 9.8 3.1 0.5 -0.8 -0.4 0.2 -1.3 -0.2
Relative age of first facial hair 1.9 4.0 7.5 1.8 2.2 0.1 0.4 2.7 2.3 2.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.5 -0.3 0.2 0.9 -1.6 1.2 -0.4 -0.7
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.4 -0.2 1.6 -0.0 -1.3 1.0 1.1 1.4
Ever had hysterectomy (womb removed) 0.0 0.1 0.2 0.3 0.1 -0.3 -0.0 -0.0 -0.2 -0.4
Systolic blood pressure, automated reading 2.1 6.1 11.0 1.8 3.3 2.5 -2.8 1.6 2.7 2.2
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.0 1.2 0.6 -1.4 0.3 1.3 -1.2 0.3
Angina 0.2 0.2 0.5 0.7 0.7 0.4 -0.3 0.6 0.3 0.3
Medication for hormone replacement therapy 0.6 0.7 1.3 -0.5 1.2 -0.1 -1.0 0.3 1.1 1.1
Vitamin and mineral supplements 1.2 1.7 3.0 1.1 1.7 1.0 -0.8 1.6 0.8 1.7
Supplements: Zinc 0.5 0.5 1.4 0.7 0.6 0.8 -0.2 0.0 0.8 1.2
Medication: Co-codamol 1.7 1.9 5.4 0.2 1.8 0.1 -2.3 2.0 0.8 -0.2
Medication: Metformin 1.9 2.7 5.1 1.2 2.2 0.1 -2.1 2.1 1.2 1.4
Diabetes (father) 1.5 1.8 6.0 -2.5 -0.8 -0.8 -0.0 0.0 -1.5 -1.8
Diabetes (mother) 1.2 1.5 3.3 -0.0 1.8 0.2 -1.8 0.9 1.3 1.2
Severe depression (siblings) 0.8 0.9 1.7 0.6 0.9 0.8 -0.7 0.6 1.2 1.3
Pack years adult smoking proportion 1.2 1.9 3.5 1.9 1.7 0.6 -0.9 1.5 0.9 1.6
Impedance of leg (right) 0.7 3.5 7.1 -1.9 -1.8 2.5 0.4 -2.7 0.4 -2.0
Leg fat-free mass (left) 0.2 1.2 2.9 0.9 -0.1 -0.8 -1.6 0.8 -1.7 -0.9
Trunk fat percentage 0.9 3.6 9.1 -1.4 0.0 -1.1 -3.0 0.7 -2.4 -2.5
Hand grip strength (right) 2.3 6.2 14.8 -0.7 -2.2 -2.6 3.8 -1.3 -3.9 -0.7
Townsend deprivation index at recruitment 0.5 0.7 1.6 1.1 0.6 -0.5 -1.3 0.7 0.5 0.7
Current tobacco smoking 2.6 4.3 8.5 1.2 2.9 1.0 -2.1 2.6 0.9 2.7
Average weekly fortified wine intake 0.1 0.1 0.2 -0.3 0.3 -0.2 -0.3 0.4 -0.2 0.1
Maternal smoking around birth 1.3 1.8 3.3 0.1 1.5 1.5 -1.6 1.8 1.5 0.7
Fed-up feelings 0.8 1.5 3.6 0.2 1.5 -0.2 -1.9 1.7 -0.7 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 4.6 1.3 2.1 1.0 -1.8 2.0 0.3 1.9
Relative age voice broke 0.4 0.6 1.3 0.5 -1.1 0.5 1.1 -0.1 0.5 -0.8
Taking other prescription medications 0.2 0.4 1.2 -0.3 -0.3 -0.6 0.1 -0.3 -0.9 -1.1
Age when periods started (menarche) 2.0 4.8 10.6 -1.7 -2.6 1.1 0.7 -3.0 -1.4 -3.3
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 5.5 -0.3 1.9 1.5 -2.3 1.1 1.6 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 3.3 -0.2 1.8 0.1 -1.6 0.6 0.9 1.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.1 -1.1 0.9 0.8 -0.8 0.9 0.8 0.4
Qualifications: CSEs or equivalent 0.4 0.5 2.8 -1.7 0.1 0.1 -0.0 -0.4 -0.3 0.6
Serious illness, injury or assault to yourself 0.8 1.0 3.7 1.9 0.8 1.3 -0.7 0.7 0.1 0.1
High blood pressure 0.6 1.7 5.3 1.3 -0.1 -0.6 -1.2 -1.0 -1.4 -2.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 1.0 0.2 -0.1 0.3 1.0 0.2 -0.1 0.1
Multivitamins +/- minerals 1.2 1.6 4.4 -1.0 -1.7 -0.5 0.6 -1.2 -0.8 -2.1
Stomach or abdominal pain in last month 0.8 1.0 3.0 -0.5 -0.9 0.1 -0.5 -1.2 -1.0 -1.7
Supplements: Glucosamine 1.1 1.4 4.6 2.1 0.3 1.1 -1.6 -0.2 1.1 0.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 3.3 -0.4 -1.3 0.4 -0.1 -1.1 -0.9 -1.8
Medication: Atenolol 0.5 0.7 1.7 1.3 0.8 0.1 -0.8 1.0 -0.7 -0.6
Medication: Levothyroxine sodium 0.8 1.3 5.3 -1.0 -0.4 -2.3 1.2 0.5 -1.0 0.1
Sitting height 0.3 2.0 5.7 0.7 -1.5 2.4 -0.9 -0.7 0.4 -2.0
Chronic bronchitis/emphysema (father) 2.2 2.6 7.3 -0.8 1.6 0.7 -2.2 2.7 1.3 0.8
High blood pressure (mother) 0.3 0.4 2.1 0.6 0.4 -0.0 -0.1 -0.1 -1.5 -0.0
Body mass index (BMI) 1.5 6.2 11.0 1.9 3.3 -1.6 -3.2 3.3 -1.1 1.9
Impedance of leg (left) 0.5 2.5 6.6 -1.9 -1.3 2.6 0.2 -1.7 1.0 -1.4
Leg predicted mass (left) 0.2 1.2 3.1 0.9 -0.1 -0.9 -1.6 0.8 -1.8 -0.9
Trunk fat mass 0.7 3.1 10.6 -0.7 0.4 -0.8 -3.3 1.1 -2.2 -2.0
Waist circumference 1.1 4.0 11.3 0.8 1.8 -1.7 -3.4 2.5 -1.7 -0.6
Number of incorrect matches in round 0.3 0.5 1.9 -0.9 -0.5 -0.4 -0.2 -0.2 -0.4 -1.4
Past tobacco smoking 0.7 1.3 3.1 -0.3 -1.5 0.7 1.0 -1.5 -0.2 -1.8
Alcohol usually taken with meals 0.2 0.3 0.5 -0.3 -0.7 0.7 0.5 -0.6 0.5 -0.7
Nervous feelings 3.0 5.5 9.7 -1.9 -3.1 -1.6 2.1 -3.1 -2.0 -2.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 3.5 1.9 0.9 1.1 -1.4 1.5 0.0 0.7
Hearing difficulty/problems with background noise 0.4 0.7 2.1 1.4 -0.3 -0.0 -0.5 -0.5 -1.2 -0.9
Hair/balding pattern: Pattern 2 0.9 1.2 2.8 1.3 1.3 -0.2 -0.5 1.1 0.8 1.7
Had menopause 0.5 0.6 1.3 0.6 0.8 0.4 -0.6 1.1 1.1 0.5
Had other major operations 1.1 1.4 3.8 0.6 0.8 1.1 -1.9 1.7 0.8 0.1
Forced vital capacity (FVC) 1.8 6.9 18.6 -2.4 -3.6 -0.2 4.3 -2.7 -1.2 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.3 7.9 0.9 2.4 1.0 -1.8 1.3 1.7 2.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.3 -0.4 0.1 -0.5 -0.1 0.0 -0.3 -0.2
Qualifications: None of the above 0.9 1.9 5.5 0.6 2.3 -0.8 -0.8 1.1 -0.6 2.1
Financial difficulties in last 2 years 0.5 0.7 2.4 -0.2 1.0 0.1 -0.8 0.9 0.2 1.5
Mouth/teeth dental problems 0.3 0.5 1.5 1.0 0.7 0.6 0.2 -0.1 0.5 1.2
Heart attack 0.5 0.6 1.8 1.4 0.0 0.7 1.1 0.0 0.2 0.7
Allergy 0.3 0.6 3.4 -0.2 0.3 0.1 -1.8 0.0 0.8 -0.1
Pain all over the body in last month 0.2 0.2 0.8 0.1 -0.0 -0.1 -0.5 0.9 -0.4 -0.1
Diabetes (self-reported) 1.4 2.2 4.1 1.9 1.8 0.1 -1.1 2.0 1.0 1.6
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.8 -0.1 0.5 -0.8 0.7 0.5 -0.2 1.3
Medication: Ramipril 1.2 1.6 5.2 1.1 -0.6 -0.7 -0.8 -0.6 -1.7 -2.3
Medication: Simvastatin 3.0 4.5 7.6 0.7 -2.3 -2.8 2.1 -1.7 -2.1 -2.4
Fluid intelligence score 1.4 2.9 6.3 2.5 0.0 2.5 -1.6 0.1 1.3 -1.9
Illnesses of siblings 0.4 0.5 1.5 -0.7 -0.4 1.2 -0.3 0.1 1.2 -0.4
Neuroticism score 0.7 1.5 5.5 -0.2 -0.3 -1.9 0.3 -0.8 -2.3 0.4
Weight 0.6 2.7 10.6 1.1 1.1 -0.3 -3.3 1.9 -1.5 -0.6
Impedance of arm (right) 2.7 12.7 29.3 -4.3 -4.4 1.1 0.6 -4.4 -1.1 -5.4
Arm fat percentage (right) 0.9 3.5 13.4 0.1 1.6 -1.2 -3.7 1.9 -1.8 -0.6
Trunk fat-free mass 0.3 1.8 4.7 2.2 0.9 0.7 -1.9 1.7 -0.1 0.5
Hip circumference 0.7 3.1 12.2 0.3 0.9 -0.2 -3.5 2.2 -1.5 -1.2
Time employed in main current job 0.3 0.3 0.9 -0.9 0.3 -0.8 0.3 0.3 0.1 0.6
Alcohol intake versus 10 years previously 0.4 0.6 1.3 -1.1 -0.8 -0.5 1.0 -0.7 -0.4 -0.6
Father’s age at death 1.2 1.6 3.3 1.3 0.6 1.8 -1.4 1.6 0.9 0.5
Worrier / anxious feelings 1.1 2.0 3.2 -1.6 -0.9 -1.8 1.1 -1.8 -1.7 0.5
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 7.1 0.4 1.5 1.7 -2.7 2.5 0.6 0.3
Falls in the last year 0.9 1.2 2.9 0.6 1.0 1.2 -1.7 1.6 -0.2 -0.3
Hair/balding pattern: Pattern 3 0.7 1.1 4.1 -0.5 -1.0 -0.1 0.4 -1.4 -2.0 -0.5
Number of live births 0.4 0.6 1.9 0.6 0.8 0.3 -1.4 1.1 0.4 0.3
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 9.1 -1.8 -2.0 -0.8 3.0 -1.1 -0.4 0.3
Pulse rate 0.3 0.5 2.2 -0.1 -0.4 -0.9 0.6 0.1 -1.5 0.4
Happiness 2.2 2.7 5.4 -0.8 -1.7 -1.9 1.4 -1.4 -2.3 -1.6
Noisy workplace 0.4 0.5 1.6 -1.0 -0.6 -0.2 1.2 -0.3 -0.7 0.3
Qualifications: A levels/AS levels or equivalent 1.0 2.1 4.1 0.9 -1.5 2.0 -1.4 -0.6 1.1 -2.0
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 6.8 2.6 0.4 1.6 -0.5 -0.0 1.6 -0.5
Mouth/teeth dental problems: Dentures 3.4 5.7 18.6 -1.3 -2.6 -1.8 0.3 -0.7 -3.0 -4.3
Asthma 0.5 1.0 3.8 -1.1 -0.8 -0.3 2.0 -1.0 -0.7 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.0 0.2 -0.8 -0.6 0.3 -0.8 -1.4 -0.7
Medication: Cholesterol lowering 1.4 2.2 5.5 0.6 -0.9 -2.4 1.9 -0.9 -1.9 -0.9
Depression (self-reported) 0.2 0.3 1.1 0.3 0.5 0.3 -1.1 0.2 -0.4 -0.3
Medication: Lansoprazole 1.5 1.7 4.6 -0.1 1.6 0.1 -0.3 1.6 1.5 2.1
Prospective memory result 0.4 0.4 1.9 -1.4 -0.1 -0.8 0.5 -0.3 -0.3 0.3
Lung cancer (father) 0.1 0.1 0.2 -0.3 -0.0 -0.5 -0.2 -0.1 -0.0 0.3
Illnesses of mother 0.6 0.8 2.7 -0.1 -1.6 0.1 1.4 -0.5 0.5 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 7.3 -1.6 -2.1 -0.5 2.7 -1.8 -0.7 -0.2
Pulse wave Arterial Stiffness index 2.0 2.4 8.6 0.0 1.6 1.4 -2.9 1.6 1.0 -0.2
Impedance of arm (left) 3.1 14.4 30.5 -4.8 -4.8 0.4 1.3 -4.3 -1.7 -5.5
Arm fat mass (right) 0.8 3.3 11.9 0.5 1.5 -1.1 -3.5 2.1 -1.8 -0.5
Trunk predicted mass 0.3 1.9 4.9 2.2 0.9 0.7 -2.0 1.7 -0.1 0.5
Standing height 1.1 10.6 31.6 -1.9 -4.8 2.4 -0.2 -3.0 -1.1 -5.6
Length of working week for main job 1.4 1.6 4.4 -0.1 -1.0 -1.5 2.1 -1.6 -0.9 -0.3
Exposure to tobacco smoke at home 0.2 0.2 0.8 -0.5 0.1 -0.9 -0.5 0.4 -0.3 -0.0
Breastfed as a baby 1.1 1.4 4.4 -2.1 -0.0 0.2 -1.2 1.8 0.8 -0.5
Tense / ‘highly strung’ 1.0 1.7 4.6 -0.4 -1.4 -1.7 0.6 -0.9 -2.2 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.5 -0.3 -0.3 -0.2 0.2 -0.7 -0.4 -0.4
Hair/balding pattern: Pattern 4 0.5 1.3 6.7 -2.6 0.1 0.3 -1.0 0.3 -1.0 -0.5
Birth weight of first child 0.4 0.8 2.6 1.0 -0.7 0.5 -0.8 -0.4 0.2 -1.6
Peak expiratory flow (PEF) 3.0 7.0 16.2 0.2 2.0 3.2 -3.2 2.2 4.0 1.7
Pulse wave reflection index 0.6 0.8 2.1 -1.2 0.8 -0.5 -1.4 0.9 0.2 0.3
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.5 0.7 0.5 0.5 -0.5 0.1 0.7 0.4
Loud music exposure frequency 0.2 0.2 0.9 -0.8 0.0 0.0 0.2 -0.9 0.0 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.6 -0.2 -1.2 -0.2 -0.3 -0.3 0.1 -0.9
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 4.9 2.0 1.3 -0.1 -0.7 0.8 0.7 2.2
Blood clot in the leg (DVT) 1.0 1.2 3.5 -1.9 -0.7 -1.0 1.6 0.9 -0.6 -0.1
Medication: Paracetamol 1.0 1.6 4.1 0.1 -1.1 -1.5 0.7 -0.9 -1.5 -2.0
Headache pain in last month 0.7 1.2 4.5 0.1 -0.9 -1.3 0.4 0.2 -2.1 -0.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.3 -1.1 -0.1 0.2 0.0 0.3 0.5 1.1
Glaucoma (self-reported) 1.4 1.6 3.4 -1.4 -0.8 -1.6 1.2 -1.0 -1.8 -0.6
Gout (self-reported) 0.2 0.2 1.1 -0.4 -0.3 -0.1 -0.4 -0.0 1.0 0.3
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 8.5 -2.2 -0.6 -2.9 1.7 0.6 -1.3 0.2
Medication: Amlodipine 1.4 1.9 6.4 -2.2 -0.4 0.0 -1.3 0.2 -0.6 -2.5
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.2 0.2 1.1 0.2 -0.8 0.4 0.1 0.1
Birth weight 0.9 1.9 3.2 1.6 -1.6 -1.0 0.2 -1.4 -1.5 -1.8
Chronic bronchitis/emphysema (mother) 3.6 4.2 7.2 1.5 2.5 2.6 -2.7 1.2 2.2 0.9
High blood pressure (siblings) 0.6 0.9 2.7 -1.6 0.3 -1.3 -0.3 0.3 -0.8 -0.8
Forced vital capacity (FVC), Best measure 1.9 7.0 14.5 -2.5 -3.6 -0.3 3.8 -3.3 -1.4 -1.6
Body fat percentage 0.8 3.2 12.4 -0.6 1.3 -0.9 -3.5 1.5 -1.9 -1.2
Leg fat percentage (right) 1.4 5.0 15.1 1.1 3.1 -0.2 -3.9 2.4 -1.2 1.2
Arm fat-free mass (right) 0.4 2.0 4.6 2.1 1.2 -0.1 -1.7 2.0 -0.7 0.8
Exposure to tobacco smoke outside home 1.3 1.7 5.5 0.1 0.4 -2.3 1.1 1.1 -1.6 1.2
Comparative body size at age 10 2.1 5.9 7.6 2.3 2.7 2.0 -2.7 1.8 2.8 2.5
Number of full brothers 1.0 1.2 5.2 2.3 0.7 1.0 0.0 1.0 -0.0 0.8
Worry too long after embarrassment 1.7 2.8 6.3 -1.2 -1.6 -2.4 1.4 -0.7 -2.5 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.6 0.8 0.5 0.0 -0.6 0.3 0.3 0.2
Wheeze or whistling in the chest in last year 0.3 0.6 2.0 -1.4 -0.1 -0.3 1.0 -0.0 -0.5 0.8
Number of children fathered 0.8 0.9 2.7 0.4 1.0 -0.4 1.1 0.9 -0.4 1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.9 -0.7 -1.0 -1.7 0.7 -0.4 -0.6 -1.3
Age at first live birth 0.6 1.1 3.8 -0.8 -1.3 0.4 -0.8 -0.8 -0.5 -2.0
Pulse wave peak to peak time 1.9 2.2 7.8 -0.1 -1.7 -1.1 2.8 -1.6 -0.9 0.0
Health satisfaction 0.7 0.9 2.8 0.9 -0.4 -1.0 -0.5 -0.2 -1.7 -1.3
Shortness of breath walking on level ground 0.4 0.5 1.6 -1.2 0.3 0.1 -0.9 0.8 -0.6 -0.1
Qualifications: College or University degree 0.8 2.4 8.4 -0.7 -2.4 0.5 0.2 -1.3 0.3 -2.9
Eye problems/disorders: None of the above 1.2 1.3 4.1 0.5 0.5 1.7 -1.2 -0.3 2.0 0.6
Mouth/teeth dental problems: Loose teeth 3.0 3.5 7.2 1.4 1.8 2.7 -2.3 1.5 1.9 1.0
Emphysema/chronic bronchitis 0.9 1.0 4.2 2.1 -0.4 1.1 -0.1 -0.7 -0.4 -0.7
Medication for pain relief, constipation, heartburn 0.7 1.3 3.8 -0.3 0.9 1.3 -0.3 -0.3 1.6 1.9
Neck or shoulder pain in last month 0.4 0.6 2.0 -0.8 0.6 -0.4 -0.8 1.4 0.4 0.2
Medication: Blood pressure 1.2 2.1 5.5 1.9 1.2 1.6 -2.3 0.3 0.4 -1.3
Angina (self-reported) 0.3 0.4 1.2 1.1 0.8 0.5 -0.6 0.6 0.3 0.3
Migraine (self-reported) 2.6 3.2 6.1 -0.6 -2.5 -1.3 2.4 -2.0 -1.6 -1.4
Medication: Ibuprofen 1.1 1.3 2.5 0.4 -1.3 -0.7 0.6 -1.4 -1.6 -1.3
Medication: Allopurinol 0.1 0.2 0.7 -0.0 -0.4 0.2 -0.5 -0.3 0.8 -0.3
Medication: Omeprazole 0.2 0.2 0.4 -0.5 0.3 -0.3 -0.6 0.6 -0.0 0.3
Medication: Seretide 50 evohaler 0.2 0.3 0.8 0.7 0.1 0.3 -0.5 -0.6 -0.2 -0.9
Mean time to correctly identify matches 1.0 1.9 4.6 0.1 -0.0 -2.1 2.1 0.0 -1.5 1.4
Heart disease (mother) 0.4 0.5 1.2 0.1 -0.1 -1.0 0.3 0.4 -1.1 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.3 0.9 0.4 -0.6 1.0 -0.3 -0.5 1.5
Whole body fat mass 0.7 2.8 10.2 -0.2 1.0 -0.9 -3.2 1.5 -2.0 -1.1
Leg fat mass (right) 1.0 3.8 12.2 1.2 2.3 -0.4 -3.5 2.3 -1.4 0.6
Arm predicted mass (right) 0.3 1.7 3.9 1.9 0.9 -0.4 -1.4 2.0 -0.9 0.6
Pulse rate, automated reading 0.3 1.1 2.7 1.0 0.8 -0.8 0.5 1.2 -1.0 1.6
Alcohol intake frequency. 0.4 0.9 1.8 -1.4 1.1 -0.2 -0.8 1.2 0.5 1.1
Comparative height size at age 10 0.9 4.8 15.7 -1.1 -3.2 -0.8 0.3 -1.3 -1.9 -4.0
Number of full sisters 0.3 0.4 1.3 -1.1 0.0 -0.5 -0.5 0.5 -0.6 -0.5
Suffer from ‘nerves’ 0.4 0.6 2.9 -1.7 -0.6 -0.2 -0.4 -0.8 0.6 -0.1
Overall health rating 0.6 1.4 3.3 -0.6 -0.5 -0.9 -1.3 -0.1 -1.8 -1.8
Chest pain or discomfort 0.2 0.2 1.0 -0.0 -0.2 -0.4 0.1 0.1 -0.6 -1.0
Had major operations 0.7 0.8 1.8 1.2 -0.5 -1.0 0.4 -0.1 -1.3 -0.8
Age at last live birth 1.6 2.3 7.0 -0.9 -2.1 -0.4 -0.1 -1.5 -1.2 -2.6
Family relationship satisfaction 0.9 1.2 2.7 -1.6 -0.4 -1.6 0.4 -0.3 -1.5 -0.7
Leg pain on walking 0.5 0.6 2.0 -0.0 0.9 0.2 -0.0 1.1 0.5 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.7 0.3 0.4 0.1 1.0 0.7 0.2 1.6
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.6 1.3 0.3 0.5 0.4 -0.7 0.3 0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.5 -1.6 -0.1 -0.3 0.0 0.7 0.6 -0.1
Medication: Aspirin 0.2 0.3 1.5 -0.1 -0.3 0.3 0.1 0.6 0.0 -1.2
Supplements: Vitamin C 0.5 0.6 1.4 1.1 0.1 -0.8 0.3 -1.2 -0.3 0.8
Knee pain experienced in last month 0.5 0.7 1.8 -1.3 0.0 -0.3 -1.2 0.1 -0.9 -1.1
Hypertension (Self-reported) 0.7 1.9 5.3 1.6 0.2 -0.6 -1.6 -0.7 -1.5 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.2 0.2 1.1 -0.3 -0.3 0.5 0.2 0.9
Illnesses of father: Heart disease 0.1 0.2 1.0 0.3 0.0 -0.2 -0.4 -0.1 0.1 -1.0
Illnesses of siblings: Diabetes 1.9 2.3 9.6 3.1 0.9 0.9 -1.8 0.5 1.2 -0.0
Smoking status: Previous 0.2 0.3 0.7 0.4 0.6 -0.8 -0.3 0.5 -0.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.8 5.3 -1.1 -2.3 0.3 0.9 -2.2 -1.4 -2.3
Whole body fat-free mass 0.2 1.4 3.3 1.8 0.5 -0.1 -1.8 1.5 -0.9 -0.0
Leg fat-free mass (right) 0.2 1.1 3.0 0.8 -0.3 -1.1 -1.2 1.0 -1.7 -0.9
Arm fat percentage (left) 0.8 3.4 10.7 -0.1 1.5 -1.6 -3.3 1.9 -2.1 -0.5
Average weekly red wine intake 0.3 0.4 1.1 1.0 0.2 -0.8 0.6 0.5 -0.3 0.7
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.2 -0.7 -1.1 -1.5 -0.4 -0.9 -0.6 -1.3
Mood swings 0.2 0.4 2.0 0.5 0.1 -0.1 -0.4 0.1 -1.4 0.4
Loneliness, isolation 1.3 1.8 5.4 1.1 1.9 0.2 -1.1 0.7 0.6 2.3
Long-standing illness, disability or infirmity 0.4 0.6 2.2 0.3 0.9 -0.1 -1.5 1.1 -0.3 -0.2
Ever had bowel cancer screening 1.4 1.6 4.0 0.6 0.0 2.0 -1.8 0.4 1.9 -0.4
Diabetes diagnosed by doctor 1.6 2.6 4.5 2.0 2.0 0.6 -1.4 2.1 1.4 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.7 -0.1 -0.1 1.6 -0.8 0.7 1.1 0.1
Friendships satisfaction 0.5 0.6 1.7 -0.3 -1.1 -1.0 0.5 0.0 -0.1 -1.3
Qualifications: nursing, teaching 1.9 2.9 7.0 2.2 1.4 2.6 -1.3 1.1 1.9 0.5
Commuting to job workplace: Walk 0.5 0.6 2.2 -0.4 -0.2 -0.5 1.5 -0.0 -0.8 0.9
Eye problems/disorders: Cataract 0.8 0.9 3.4 0.1 -0.2 -1.3 1.9 0.4 -0.9 0.7
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.7 -2.2 0.5 1.5 -0.8 1.1 1.4 0.3
Medication for cholesterol 0.5 0.8 3.2 0.3 0.1 1.8 -0.1 0.9 0.9 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 4.2 0.1 1.6 0.2 -1.4 2.0 0.5 0.8
Back pain experienced in last month 0.2 0.3 1.2 -0.6 -0.0 1.1 -0.3 -0.2 0.6 -0.2
Mineral and other dietary supplements 0.9 1.3 3.5 0.1 1.1 0.7 0.1 1.9 1.1 1.6
Breast cancer (self-reported) 0.1 0.1 0.6 -0.3 0.1 0.3 -0.5 0.8 0.1 -0.1
Asthma (self-reported) 0.3 0.6 2.8 -0.6 -0.4 0.0 1.7 -0.8 -0.5 0.1
Osteoporosis (self-reported) 3.8 4.7 12.3 -2.1 -2.6 -0.6 0.4 -1.9 -2.3 -3.5
Osteoarthritis (self-reported) 0.4 0.5 1.5 0.6 -0.9 -0.5 -0.5 -0.7 -0.1 -1.2
Medication: Aspirin 0.4 0.6 1.4 0.4 0.2 0.7 -0.7 1.1 0.5 -1.2
Medication: Gliclazide 0.3 0.4 1.8 -1.4 -0.3 -0.5 -0.0 0.2 0.4 -0.5
Illnesses of father: None of the above (group 1) 0.3 0.4 1.6 0.6 0.4 0.0 0.5 -0.5 0.4 1.3
Smoking status: Current 3.0 4.7 9.4 0.8 3.1 0.9 -2.4 2.8 0.9 2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 -0.2 0.7 0.0 1.1 0.5 0.3 1.1
Whole body water mass 0.3 1.5 3.5 1.8 0.7 -0.1 -1.9 1.7 -0.9 0.1
Leg predicted mass (right) 0.2 1.2 3.1 0.8 -0.2 -1.2 -1.2 1.0 -1.8 -0.9
Arm fat mass (left) 0.8 3.4 10.3 0.5 1.5 -1.4 -3.2 2.2 -2.0 -0.4
Number of self-reported non-cancer illnesses 0.9 1.6 4.5 0.9 -0.6 -1.7 0.2 -0.7 -2.1 -1.5
Average weekly champagne plus white wine intake 1.4 1.9 6.1 0.7 -1.0 2.5 -1.0 -0.7 1.0 -1.8
Miserableness 0.8 1.3 3.8 1.9 1.2 -0.2 -0.8 0.6 -0.7 1.6
Guilty feelings 0.3 0.5 2.4 0.4 -0.1 -0.3 -0.6 -0.3 -1.6 0.1
Wears glasses or contact lenses 0.4 0.5 1.2 1.1 0.4 -0.6 -0.6 1.0 -0.3 -0.6
Ever taken oral contraceptive pill 2.3 2.6 9.0 3.0 1.3 1.9 -1.2 -0.2 0.5 1.3
Hearing aid user 1.8 2.0 6.5 -0.4 -1.1 -1.2 0.5 -1.0 -1.9 -2.5
Mother’s age at death 0.8 0.9 2.3 -1.1 0.7 0.2 -1.5 1.4 0.6 -0.1
Financial situation satisfaction 0.6 0.7 3.0 -1.7 0.3 -0.9 0.1 0.8 -0.6 0.6
Tinnitus: Yes, now most or all of the time 3.7 4.4 14.9 -0.5 -1.0 -3.9 1.7 -0.7 -3.3 -0.1
Commuting to job workplace: Public transport 0.6 0.8 2.5 -0.7 -1.3 0.2 0.7 -0.3 0.0 -1.6
Eye problems/disorders: Glaucoma 1.6 1.9 5.0 -1.4 -0.6 -1.9 1.2 -0.7 -2.2 -0.7
Medication: Blood pressure 0.5 1.0 3.5 0.5 -0.4 -0.9 -0.7 -1.1 -1.0 -1.9
Pain type(s) experienced in last month: Hip pain 1.7 2.1 3.2 -1.7 -1.8 -1.2 1.3 -0.4 -1.7 -1.5
Supplements: Fish oil (including cod liver oil) 1.3 1.7 4.5 -0.5 -1.2 -1.1 1.1 -2.1 -1.6 -0.9
High cholesterol (Self-reported) 3.5 6.3 14.9 -1.2 -1.9 -3.9 3.2 -1.9 -2.9 -1.4
Medication: Bendroflumethiazide 1.6 2.4 5.4 2.1 1.7 1.8 -2.3 0.5 1.0 -0.0
Medication: Paracetamol 1.4 2.2 5.8 0.1 -1.4 -1.4 0.6 -1.2 -2.0 -2.4
Medication: Lisinopril 0.6 0.8 2.8 -1.2 0.4 0.9 0.0 0.2 1.7 0.4
Medication: Atorvastatin 0.6 0.7 2.2 0.1 0.2 -1.5 1.2 -0.1 -1.0 0.3
Illnesses of father: High blood pressure 0.4 0.4 1.4 -1.2 -0.1 -0.3 -0.5 0.2 -0.8 -0.8
Alcohol drinker status: Never 0.8 1.0 1.7 -1.1 1.0 -1.3 0.4 1.0 -0.7 1.2
Ever smoked 1.0 1.8 4.8 0.8 1.6 -0.3 -1.3 1.5 0.5 2.2
Basal metabolic rate 0.3 1.7 4.8 1.6 0.7 -0.2 -2.2 1.6 -1.1 -0.1
Leg fat percentage (left) 1.8 6.6 16.7 1.3 3.7 -0.2 -4.1 3.2 -0.8 1.7
Arm fat-free mass (left) 0.4 1.9 4.2 1.8 1.1 -0.4 -2.0 2.0 -0.8 0.5
Number of operations (self-reported) 1.5 2.2 7.5 1.8 0.9 -0.2 -2.7 1.4 -0.7 -1.1
Average weekly beer plus cider intake 0.5 0.7 2.6 -0.1 0.9 -0.6 -0.8 0.5 -0.4 1.6
Irritability 0.7 1.2 3.4 1.7 0.4 -0.6 1.3 -0.5 -0.5 1.8
Risk taking 0.3 0.5 2.6 -1.6 -0.5 -0.6 -0.0 -0.2 -0.4 -0.4
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.8 -1.3 0.0 0.0 -1.2 1.3 0.8 0.1
Fractured/broken bones in last 5 years 1.6 2.1 4.1 1.5 1.0 1.9 -2.0 1.4 1.0 -0.6
Age started oral contraceptive pill 1.0 1.2 3.5 1.9 1.3 0.7 -1.3 0.7 0.2 0.7
Diastolic blood pressure, automated reading 0.3 0.8 2.2 1.5 0.8 -0.1 -0.2 0.0 -1.5 0.7
Ever depressed for a whole week 0.9 1.1 2.9 -0.1 -1.3 -0.9 0.9 -0.8 -1.0 -1.7
Unable to work because of sickness or disability 0.3 0.4 1.0 -0.2 0.7 1.0 -0.8 0.5 -0.2 -0.4
Commuting to job workplace: Cycle 2.0 2.4 6.1 1.9 1.3 2.5 -0.3 0.9 1.3 1.7
Myopia 0.7 1.0 2.0 -1.1 -0.3 0.7 -1.3 -0.2 1.1 -1.4
Vascular/heart problems diagnosed by doctor 0.5 1.5 4.0 -1.4 0.0 0.8 0.9 0.5 1.6 2.0
Cholesterol lowering medication 1.0 1.5 5.0 0.5 -0.8 -2.2 1.0 -0.9 -1.6 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.6 0.2 0.4 -0.2 -0.1 0.8 0.1 0.5
Pain experienced in last month 0.3 0.6 2.7 1.6 0.0 0.0 0.5 -0.8 -0.1 -0.5
Supplements: Calcium 0.8 0.9 2.0 -0.1 -1.4 -0.7 0.7 -1.2 -0.6 -1.2
Basal cell carcinoma (self-reported) 0.3 0.3 1.5 0.1 0.1 -0.6 -0.1 1.2 -0.1 -0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.8 1.7 0.3 0.9 0.8 0.2 0.3 0.8
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 5.1 -2.2 -0.8 -0.9 1.5 1.0 -0.4 -0.0
Heart disease (siblings) 1.1 1.4 3.4 -0.3 -0.1 -1.8 1.7 -0.1 -1.8 0.3
Alcohol drinker status: Previous 1.2 1.4 4.3 -0.0 1.2 0.8 -2.1 1.5 0.9 0.2
Pack years of smoking 1.0 1.5 2.8 1.7 1.5 0.4 -0.9 1.6 0.7 1.3
Impedance of whole body 2.3 11.7 23.7 -4.4 -4.3 1.1 1.4 -4.0 -1.1 -4.9
Leg fat mass (left) 1.1 4.3 12.4 1.2 2.6 -0.4 -3.5 2.7 -1.2 0.9
Arm predicted mass (left) 0.4 2.1 4.3 1.9 1.2 -0.2 -2.1 2.0 -0.6 0.5