Hub : Genes

PRR15L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0923	0.0411	3.7e-04	0.001	0.016	0.024	NA	0.004	0.16000	2.2e-04	9.6e-06	NA	3.9e-02
2	TCGA	Colon Adenocarcinoma	0.1450	0.0590	1.4e-05	0.051	0.084	0.099	NA	0.101	0.00067	1.4e-05	2.4e-06	NA	2.0e-06
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0410	0.0250	9.3e-03	0.023	0.035	0.036	NA	0.030	0.01700	4.1e-03	3.9e-03	NA	7.4e-03
4	TCGA	Brain Lower Grade Glioma	0.0785	0.0337	1.4e-05	0.007	0.030	0.026	NA	0.024	0.05000	1.9e-04	5.8e-04	NA	8.2e-04
5	TCGA	Lung Squamous Cell Carcinoma	0.0482	0.0284	7.2e-03	0.017	0.012	0.025	NA	0.027	0.00400	1.4e-02	7.0e-04	NA	3.9e-04
6	TCGA	Prostate Adenocarcinoma	0.0343	0.0172	1.2e-04	0.017	0.033	0.032	NA	0.023	0.00590	2.0e-04	2.4e-04	NA	1.7e-03
7	TCGA	Thyroid Carcinoma	0.0620	0.0320	4.5e-04	0.023	0.042	0.025	NA	0.021	0.00250	5.2e-05	1.5e-03	NA	3.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.5	2.4	4.1	-0.8	-1.5	-1.8	1.6	-2.0	-2.0	-0.0
Bipolar Disorder or Schizophrenia	0.6	1.4	4.2	-0.4	-0.9	-1.6	0.5	-1.4	-2.0	-0.1
Depressed Affect (Nagel 2018)	0.5	1.0	1.9	0.2	1.4	-0.1	-1.2	0.5	-1.3	1.2
Depression (Nagel 2018)	1.3	1.9	4.6	0.7	1.7	1.5	-2.1	1.2	0.5	1.3
Intelligence (Savage-Jansen 2018)	1.3	4.1	11.8	2.1	-0.2	3.4	-1.8	0.2	2.7	-1.3
Neuroticism (Nagel 2018)	0.5	1.1	4.8	-0.5	-0.1	-1.2	0.2	-0.9	-2.2	0.3
Schizophrenia (2018)	0.1	0.3	1.0	0.2	0.1	-0.6	-0.7	-0.2	-1.0	-0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	0.8	0.4	1.0	-1.1	0.6	0.6	-0.2
Worry (Nagel 2018)	2.0	4.3	7.5	-2.2	-2.4	-1.5	1.8	-2.7	-2.3	-1.1
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	-1.1	0.8	-0.6	-0.4	0.8	0.2	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.3	0.3	0.3	-0.3	0.3	-0.3	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.8	-0.8	0.5	-1.3	0.1	0.5	-0.8	-0.1
Crohns Disease (2017)	2.4	5.2	10.3	-1.3	-2.9	-1.7	1.5	-2.9	-1.8	-3.2
Irritable Bowel Disease (IBD)	3.7	8.8	17.6	-0.7	-3.9	-1.2	1.8	-4.2	-2.7	-4.1
Ulcerative Colitis (UC)	3.1	5.9	12.6	-0.1	-3.2	-0.5	1.7	-3.5	-2.6	-2.9
Major Depression (MDD)	0.5	0.7	2.0	-0.7	0.3	0.9	-1.4	0.6	0.7	-0.6
Reaction Time	1.8	3.4	9.7	-0.5	-0.9	-2.6	3.1	-1.1	-2.0	0.9
Verbal and Numeric Reasoning (VNR)	2.2	5.2	14.6	3.0	0.6	3.8	-2.3	0.8	2.5	-0.8
Breast Cancer	0.6	1.5	4.6	2.1	0.8	-1.1	-1.7	0.9	-0.2	-0.1
Ovarian Cancer	10.5	13.8	27.9	-2.8	-3.1	-5.3	4.4	-1.8	-5.0	-2.2
Prostate Cancer	1.7	2.4	7.1	0.8	-0.8	2.7	-1.4	-0.1	1.0	-2.4
Age at First Birth	0.5	0.8	2.8	0.9	-0.4	1.7	-0.3	-0.9	0.6	-0.6
Bipolar Disorder (2011)	2.3	2.3	4.8	-1.0	-1.1	-2.0	2.2	-1.5	-1.5	0.3
Body Mass Index (BMI) (2010)	1.2	1.6	4.2	1.9	0.9	-1.0	-2.0	1.1	-0.6	-0.4
Coronary Artery Disease (CAD)	0.8	1.0	2.3	-1.4	-1.0	-0.4	1.5	-0.9	-0.9	-0.0
Crohns Disease (2012)	2.0	3.2	5.5	-1.2	-2.4	-1.4	1.9	-1.9	-1.1	-2.3
Mean Putamen Volume	0.5	0.6	2.2	-0.7	-0.7	0.3	-0.6	0.1	0.6	-1.5
Fasting Glucose	0.5	0.6	2.7	-1.6	-0.1	0.4	0.3	-0.2	1.0	-0.4
HbA1C	1.6	1.7	3.4	1.1	1.5	1.1	-0.4	0.9	1.8	1.8
HDL Cholesterol	1.9	3.2	8.4	-1.8	-2.9	-0.1	2.1	-1.5	-0.4	-1.8
LDL Cholesterol	1.6	2.6	3.9	-0.8	-1.9	-1.9	2.0	-1.7	-1.8	-0.7
Lupus	2.3	3.5	9.6	0.0	-2.7	0.2	3.1	-2.5	-0.5	-1.0
Neuroticism (2016)	0.4	0.5	0.9	0.8	0.5	-0.2	-1.0	0.5	-0.9	0.7
Primary Biliary Cirrhosis	3.5	5.0	11.2	-1.1	-2.7	-2.2	1.2	-1.8	-2.3	-3.3
Rheumatoid Arthritis	0.2	0.2	0.6	-0.2	0.4	0.5	-0.1	-0.1	0.7	0.6
Schizophrenia (2014)	0.2	0.4	1.3	0.0	0.1	-1.1	-0.4	-0.1	-1.0	0.5
Triglycerides	0.4	0.7	2.4	-0.6	1.0	-0.0	-1.6	0.6	0.8	0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.5	-0.2	1.2	0.1	-1.6	-0.2	0.2	-0.9
Ulcerative Colitis	2.0	2.9	6.3	0.2	-2.5	0.2	1.2	-2.4	-1.2	-2.3
Blood Eosinophil Count	0.7	5.5	14.2	-0.1	1.6	3.4	-1.2	1.3	3.8	2.6
Blood Platelet Count	0.7	8.3	22.0	0.6	-0.2	4.7	-4.5	-0.8	1.8	-3.4
Blood Red Count	5.1	49.3	112.4	-3.1	-6.0	-10.1	6.6	-5.3	-10.6	-3.7
Blood White Count	4.2	31.0	57.2	4.1	6.6	6.0	-7.6	4.8	5.4	3.2
Heel T-Score	2.6	20.5	42.5	1.5	6.5	0.6	-4.6	4.8	3.5	6.5
BMI	1.4	8.0	22.7	1.7	3.7	-0.7	-4.8	3.6	-1.1	1.5
Height	1.0	20.2	64.5	-1.9	-6.5	4.4	-0.4	-3.3	-1.0	-8.0
Waist Hip Ratio (WHR)	0.4	1.9	7.6	-0.2	-0.4	-2.8	0.6	-1.1	-1.4	-1.4
Systolic Blood Pressure	1.3	6.3	15.0	0.7	2.9	3.9	-3.1	0.6	2.9	1.3
Smoking Status	2.8	6.8	15.7	1.3	4.0	0.4	-3.1	3.0	1.1	3.2
Allergy or Eczema	0.6	1.5	3.8	0.4	1.4	1.1	-0.3	2.0	0.8	1.6
Cardiovascular Disease	0.8	2.5	6.2	-0.6	-0.9	-1.9	0.6	-1.9	-2.5	-1.7
Hypothyroidism (self reported)	1.5	3.4	10.2	-2.1	-1.5	-3.2	1.9	-0.5	-1.4	-1.1
Respiratory disease	0.3	0.6	1.5	-1.1	-0.8	0.2	1.2	-0.9	-0.2	-0.0
Type 2 Diabetes (T2D) (2018)	1.4	2.6	4.2	1.9	2.0	0.9	-1.7	1.5	1.7	1.2
Lung FEV1/FVC ratio	4.1	20.9	37.6	3.8	6.1	1.6	-4.5	5.0	4.2	5.3
Lung FVC	1.8	9.2	42.8	-1.6	-2.2	-1.4	6.5	-2.5	-1.7	1.8
Neuroticism	0.5	1.2	5.3	-0.3	-0.5	-1.2	0.2	-1.0	-2.3	-0.3
Chronotype (morning person)	1.6	3.6	14.7	-0.5	-0.3	-3.8	2.1	0.8	-2.2	0.7
Hair Pigment	5.8	165.1	436.8	1.2	16.1	-1.4	-1.0	20.9	11.6	17.9
Tanning	0.3	3.1	6.4	-0.7	-2.3	-0.1	0.7	-1.9	-2.5	-2.4
Hand grip strength (left)	2.6	6.8	17.2	-0.9	-2.1	-3.3	4.1	-1.4	-3.6	0.0
Number of treatments/medications taken	1.1	2.0	5.8	-0.5	-1.0	-1.7	0.1	-0.6	-1.8	-2.4
Average weekly spirits intake	0.9	1.1	3.8	-0.6	0.7	-1.9	0.0	1.3	-0.9	0.8
Sensitivity / hurt feelings	0.8	1.4	3.4	0.1	1.3	-1.9	0.5	0.2	-1.1	1.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	1.1	0.5	-0.1	-1.2	0.5	-0.9	0.1
Hearing difficulty/problems: Yes	1.2	1.8	9.8	3.1	0.5	-0.8	-0.4	0.2	-1.3	-0.2
Relative age of first facial hair	1.9	4.0	7.5	1.8	2.2	0.1	0.4	2.7	2.3	2.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.5	-0.3	0.2	0.9	-1.6	1.2	-0.4	-0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.4	-0.2	1.6	-0.0	-1.3	1.0	1.1	1.4
Ever had hysterectomy (womb removed)	0.0	0.1	0.2	0.3	0.1	-0.3	-0.0	-0.0	-0.2	-0.4
Systolic blood pressure, automated reading	2.1	6.1	11.0	1.8	3.3	2.5	-2.8	1.6	2.7	2.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.0	1.2	0.6	-1.4	0.3	1.3	-1.2	0.3
Angina	0.2	0.2	0.5	0.7	0.7	0.4	-0.3	0.6	0.3	0.3
Medication for hormone replacement therapy	0.6	0.7	1.3	-0.5	1.2	-0.1	-1.0	0.3	1.1	1.1
Vitamin and mineral supplements	1.2	1.7	3.0	1.1	1.7	1.0	-0.8	1.6	0.8	1.7
Supplements: Zinc	0.5	0.5	1.4	0.7	0.6	0.8	-0.2	0.0	0.8	1.2
Medication: Co-codamol	1.7	1.9	5.4	0.2	1.8	0.1	-2.3	2.0	0.8	-0.2
Medication: Metformin	1.9	2.7	5.1	1.2	2.2	0.1	-2.1	2.1	1.2	1.4
Diabetes (father)	1.5	1.8	6.0	-2.5	-0.8	-0.8	-0.0	0.0	-1.5	-1.8
Diabetes (mother)	1.2	1.5	3.3	-0.0	1.8	0.2	-1.8	0.9	1.3	1.2
Severe depression (siblings)	0.8	0.9	1.7	0.6	0.9	0.8	-0.7	0.6	1.2	1.3
Pack years adult smoking proportion	1.2	1.9	3.5	1.9	1.7	0.6	-0.9	1.5	0.9	1.6
Impedance of leg (right)	0.7	3.5	7.1	-1.9	-1.8	2.5	0.4	-2.7	0.4	-2.0
Leg fat-free mass (left)	0.2	1.2	2.9	0.9	-0.1	-0.8	-1.6	0.8	-1.7	-0.9
Trunk fat percentage	0.9	3.6	9.1	-1.4	0.0	-1.1	-3.0	0.7	-2.4	-2.5
Hand grip strength (right)	2.3	6.2	14.8	-0.7	-2.2	-2.6	3.8	-1.3	-3.9	-0.7
Townsend deprivation index at recruitment	0.5	0.7	1.6	1.1	0.6	-0.5	-1.3	0.7	0.5	0.7
Current tobacco smoking	2.6	4.3	8.5	1.2	2.9	1.0	-2.1	2.6	0.9	2.7
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	0.3	-0.2	-0.3	0.4	-0.2	0.1
Maternal smoking around birth	1.3	1.8	3.3	0.1	1.5	1.5	-1.6	1.8	1.5	0.7
Fed-up feelings	0.8	1.5	3.6	0.2	1.5	-0.2	-1.9	1.7	-0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	4.6	1.3	2.1	1.0	-1.8	2.0	0.3	1.9
Relative age voice broke	0.4	0.6	1.3	0.5	-1.1	0.5	1.1	-0.1	0.5	-0.8
Taking other prescription medications	0.2	0.4	1.2	-0.3	-0.3	-0.6	0.1	-0.3	-0.9	-1.1
Age when periods started (menarche)	2.0	4.8	10.6	-1.7	-2.6	1.1	0.7	-3.0	-1.4	-3.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.5	-0.3	1.9	1.5	-2.3	1.1	1.6	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.3	-0.2	1.8	0.1	-1.6	0.6	0.9	1.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.1	-1.1	0.9	0.8	-0.8	0.9	0.8	0.4
Qualifications: CSEs or equivalent	0.4	0.5	2.8	-1.7	0.1	0.1	-0.0	-0.4	-0.3	0.6
Serious illness, injury or assault to yourself	0.8	1.0	3.7	1.9	0.8	1.3	-0.7	0.7	0.1	0.1
High blood pressure	0.6	1.7	5.3	1.3	-0.1	-0.6	-1.2	-1.0	-1.4	-2.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	1.0	0.2	-0.1	0.3	1.0	0.2	-0.1	0.1
Multivitamins +/- minerals	1.2	1.6	4.4	-1.0	-1.7	-0.5	0.6	-1.2	-0.8	-2.1
Stomach or abdominal pain in last month	0.8	1.0	3.0	-0.5	-0.9	0.1	-0.5	-1.2	-1.0	-1.7
Supplements: Glucosamine	1.1	1.4	4.6	2.1	0.3	1.1	-1.6	-0.2	1.1	0.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	3.3	-0.4	-1.3	0.4	-0.1	-1.1	-0.9	-1.8
Medication: Atenolol	0.5	0.7	1.7	1.3	0.8	0.1	-0.8	1.0	-0.7	-0.6
Medication: Levothyroxine sodium	0.8	1.3	5.3	-1.0	-0.4	-2.3	1.2	0.5	-1.0	0.1
Sitting height	0.3	2.0	5.7	0.7	-1.5	2.4	-0.9	-0.7	0.4	-2.0
Chronic bronchitis/emphysema (father)	2.2	2.6	7.3	-0.8	1.6	0.7	-2.2	2.7	1.3	0.8
High blood pressure (mother)	0.3	0.4	2.1	0.6	0.4	-0.0	-0.1	-0.1	-1.5	-0.0
Body mass index (BMI)	1.5	6.2	11.0	1.9	3.3	-1.6	-3.2	3.3	-1.1	1.9
Impedance of leg (left)	0.5	2.5	6.6	-1.9	-1.3	2.6	0.2	-1.7	1.0	-1.4
Leg predicted mass (left)	0.2	1.2	3.1	0.9	-0.1	-0.9	-1.6	0.8	-1.8	-0.9
Trunk fat mass	0.7	3.1	10.6	-0.7	0.4	-0.8	-3.3	1.1	-2.2	-2.0
Waist circumference	1.1	4.0	11.3	0.8	1.8	-1.7	-3.4	2.5	-1.7	-0.6
Number of incorrect matches in round	0.3	0.5	1.9	-0.9	-0.5	-0.4	-0.2	-0.2	-0.4	-1.4
Past tobacco smoking	0.7	1.3	3.1	-0.3	-1.5	0.7	1.0	-1.5	-0.2	-1.8
Alcohol usually taken with meals	0.2	0.3	0.5	-0.3	-0.7	0.7	0.5	-0.6	0.5	-0.7
Nervous feelings	3.0	5.5	9.7	-1.9	-3.1	-1.6	2.1	-3.1	-2.0	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.5	1.9	0.9	1.1	-1.4	1.5	0.0	0.7
Hearing difficulty/problems with background noise	0.4	0.7	2.1	1.4	-0.3	-0.0	-0.5	-0.5	-1.2	-0.9
Hair/balding pattern: Pattern 2	0.9	1.2	2.8	1.3	1.3	-0.2	-0.5	1.1	0.8	1.7
Had menopause	0.5	0.6	1.3	0.6	0.8	0.4	-0.6	1.1	1.1	0.5
Had other major operations	1.1	1.4	3.8	0.6	0.8	1.1	-1.9	1.7	0.8	0.1
Forced vital capacity (FVC)	1.8	6.9	18.6	-2.4	-3.6	-0.2	4.3	-2.7	-1.2	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.3	7.9	0.9	2.4	1.0	-1.8	1.3	1.7	2.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.4	0.1	-0.5	-0.1	0.0	-0.3	-0.2
Qualifications: None of the above	0.9	1.9	5.5	0.6	2.3	-0.8	-0.8	1.1	-0.6	2.1
Financial difficulties in last 2 years	0.5	0.7	2.4	-0.2	1.0	0.1	-0.8	0.9	0.2	1.5
Mouth/teeth dental problems	0.3	0.5	1.5	1.0	0.7	0.6	0.2	-0.1	0.5	1.2
Heart attack	0.5	0.6	1.8	1.4	0.0	0.7	1.1	0.0	0.2	0.7
Allergy	0.3	0.6	3.4	-0.2	0.3	0.1	-1.8	0.0	0.8	-0.1
Pain all over the body in last month	0.2	0.2	0.8	0.1	-0.0	-0.1	-0.5	0.9	-0.4	-0.1
Diabetes (self-reported)	1.4	2.2	4.1	1.9	1.8	0.1	-1.1	2.0	1.0	1.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	-0.1	0.5	-0.8	0.7	0.5	-0.2	1.3
Medication: Ramipril	1.2	1.6	5.2	1.1	-0.6	-0.7	-0.8	-0.6	-1.7	-2.3
Medication: Simvastatin	3.0	4.5	7.6	0.7	-2.3	-2.8	2.1	-1.7	-2.1	-2.4
Fluid intelligence score	1.4	2.9	6.3	2.5	0.0	2.5	-1.6	0.1	1.3	-1.9
Illnesses of siblings	0.4	0.5	1.5	-0.7	-0.4	1.2	-0.3	0.1	1.2	-0.4
Neuroticism score	0.7	1.5	5.5	-0.2	-0.3	-1.9	0.3	-0.8	-2.3	0.4
Weight	0.6	2.7	10.6	1.1	1.1	-0.3	-3.3	1.9	-1.5	-0.6
Impedance of arm (right)	2.7	12.7	29.3	-4.3	-4.4	1.1	0.6	-4.4	-1.1	-5.4
Arm fat percentage (right)	0.9	3.5	13.4	0.1	1.6	-1.2	-3.7	1.9	-1.8	-0.6
Trunk fat-free mass	0.3	1.8	4.7	2.2	0.9	0.7	-1.9	1.7	-0.1	0.5
Hip circumference	0.7	3.1	12.2	0.3	0.9	-0.2	-3.5	2.2	-1.5	-1.2
Time employed in main current job	0.3	0.3	0.9	-0.9	0.3	-0.8	0.3	0.3	0.1	0.6
Alcohol intake versus 10 years previously	0.4	0.6	1.3	-1.1	-0.8	-0.5	1.0	-0.7	-0.4	-0.6
Father’s age at death	1.2	1.6	3.3	1.3	0.6	1.8	-1.4	1.6	0.9	0.5
Worrier / anxious feelings	1.1	2.0	3.2	-1.6	-0.9	-1.8	1.1	-1.8	-1.7	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	7.1	0.4	1.5	1.7	-2.7	2.5	0.6	0.3
Falls in the last year	0.9	1.2	2.9	0.6	1.0	1.2	-1.7	1.6	-0.2	-0.3
Hair/balding pattern: Pattern 3	0.7	1.1	4.1	-0.5	-1.0	-0.1	0.4	-1.4	-2.0	-0.5
Number of live births	0.4	0.6	1.9	0.6	0.8	0.3	-1.4	1.1	0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	9.1	-1.8	-2.0	-0.8	3.0	-1.1	-0.4	0.3
Pulse rate	0.3	0.5	2.2	-0.1	-0.4	-0.9	0.6	0.1	-1.5	0.4
Happiness	2.2	2.7	5.4	-0.8	-1.7	-1.9	1.4	-1.4	-2.3	-1.6
Noisy workplace	0.4	0.5	1.6	-1.0	-0.6	-0.2	1.2	-0.3	-0.7	0.3
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.1	0.9	-1.5	2.0	-1.4	-0.6	1.1	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	6.8	2.6	0.4	1.6	-0.5	-0.0	1.6	-0.5
Mouth/teeth dental problems: Dentures	3.4	5.7	18.6	-1.3	-2.6	-1.8	0.3	-0.7	-3.0	-4.3
Asthma	0.5	1.0	3.8	-1.1	-0.8	-0.3	2.0	-1.0	-0.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	0.2	-0.8	-0.6	0.3	-0.8	-1.4	-0.7
Medication: Cholesterol lowering	1.4	2.2	5.5	0.6	-0.9	-2.4	1.9	-0.9	-1.9	-0.9
Depression (self-reported)	0.2	0.3	1.1	0.3	0.5	0.3	-1.1	0.2	-0.4	-0.3
Medication: Lansoprazole	1.5	1.7	4.6	-0.1	1.6	0.1	-0.3	1.6	1.5	2.1
Prospective memory result	0.4	0.4	1.9	-1.4	-0.1	-0.8	0.5	-0.3	-0.3	0.3
Lung cancer (father)	0.1	0.1	0.2	-0.3	-0.0	-0.5	-0.2	-0.1	-0.0	0.3
Illnesses of mother	0.6	0.8	2.7	-0.1	-1.6	0.1	1.4	-0.5	0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	7.3	-1.6	-2.1	-0.5	2.7	-1.8	-0.7	-0.2
Pulse wave Arterial Stiffness index	2.0	2.4	8.6	0.0	1.6	1.4	-2.9	1.6	1.0	-0.2
Impedance of arm (left)	3.1	14.4	30.5	-4.8	-4.8	0.4	1.3	-4.3	-1.7	-5.5
Arm fat mass (right)	0.8	3.3	11.9	0.5	1.5	-1.1	-3.5	2.1	-1.8	-0.5
Trunk predicted mass	0.3	1.9	4.9	2.2	0.9	0.7	-2.0	1.7	-0.1	0.5
Standing height	1.1	10.6	31.6	-1.9	-4.8	2.4	-0.2	-3.0	-1.1	-5.6
Length of working week for main job	1.4	1.6	4.4	-0.1	-1.0	-1.5	2.1	-1.6	-0.9	-0.3
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.5	0.1	-0.9	-0.5	0.4	-0.3	-0.0
Breastfed as a baby	1.1	1.4	4.4	-2.1	-0.0	0.2	-1.2	1.8	0.8	-0.5
Tense / ‘highly strung’	1.0	1.7	4.6	-0.4	-1.4	-1.7	0.6	-0.9	-2.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.5	-0.3	-0.3	-0.2	0.2	-0.7	-0.4	-0.4
Hair/balding pattern: Pattern 4	0.5	1.3	6.7	-2.6	0.1	0.3	-1.0	0.3	-1.0	-0.5
Birth weight of first child	0.4	0.8	2.6	1.0	-0.7	0.5	-0.8	-0.4	0.2	-1.6
Peak expiratory flow (PEF)	3.0	7.0	16.2	0.2	2.0	3.2	-3.2	2.2	4.0	1.7
Pulse wave reflection index	0.6	0.8	2.1	-1.2	0.8	-0.5	-1.4	0.9	0.2	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	0.7	0.5	0.5	-0.5	0.1	0.7	0.4
Loud music exposure frequency	0.2	0.2	0.9	-0.8	0.0	0.0	0.2	-0.9	0.0	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.6	-0.2	-1.2	-0.2	-0.3	-0.3	0.1	-0.9
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.9	2.0	1.3	-0.1	-0.7	0.8	0.7	2.2
Blood clot in the leg (DVT)	1.0	1.2	3.5	-1.9	-0.7	-1.0	1.6	0.9	-0.6	-0.1
Medication: Paracetamol	1.0	1.6	4.1	0.1	-1.1	-1.5	0.7	-0.9	-1.5	-2.0
Headache pain in last month	0.7	1.2	4.5	0.1	-0.9	-1.3	0.4	0.2	-2.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	-1.1	-0.1	0.2	0.0	0.3	0.5	1.1
Glaucoma (self-reported)	1.4	1.6	3.4	-1.4	-0.8	-1.6	1.2	-1.0	-1.8	-0.6
Gout (self-reported)	0.2	0.2	1.1	-0.4	-0.3	-0.1	-0.4	-0.0	1.0	0.3
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	8.5	-2.2	-0.6	-2.9	1.7	0.6	-1.3	0.2
Medication: Amlodipine	1.4	1.9	6.4	-2.2	-0.4	0.0	-1.3	0.2	-0.6	-2.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.2	0.2	1.1	0.2	-0.8	0.4	0.1	0.1
Birth weight	0.9	1.9	3.2	1.6	-1.6	-1.0	0.2	-1.4	-1.5	-1.8
Chronic bronchitis/emphysema (mother)	3.6	4.2	7.2	1.5	2.5	2.6	-2.7	1.2	2.2	0.9
High blood pressure (siblings)	0.6	0.9	2.7	-1.6	0.3	-1.3	-0.3	0.3	-0.8	-0.8
Forced vital capacity (FVC), Best measure	1.9	7.0	14.5	-2.5	-3.6	-0.3	3.8	-3.3	-1.4	-1.6
Body fat percentage	0.8	3.2	12.4	-0.6	1.3	-0.9	-3.5	1.5	-1.9	-1.2
Leg fat percentage (right)	1.4	5.0	15.1	1.1	3.1	-0.2	-3.9	2.4	-1.2	1.2
Arm fat-free mass (right)	0.4	2.0	4.6	2.1	1.2	-0.1	-1.7	2.0	-0.7	0.8
Exposure to tobacco smoke outside home	1.3	1.7	5.5	0.1	0.4	-2.3	1.1	1.1	-1.6	1.2
Comparative body size at age 10	2.1	5.9	7.6	2.3	2.7	2.0	-2.7	1.8	2.8	2.5
Number of full brothers	1.0	1.2	5.2	2.3	0.7	1.0	0.0	1.0	-0.0	0.8
Worry too long after embarrassment	1.7	2.8	6.3	-1.2	-1.6	-2.4	1.4	-0.7	-2.5	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.8	0.5	0.0	-0.6	0.3	0.3	0.2
Wheeze or whistling in the chest in last year	0.3	0.6	2.0	-1.4	-0.1	-0.3	1.0	-0.0	-0.5	0.8
Number of children fathered	0.8	0.9	2.7	0.4	1.0	-0.4	1.1	0.9	-0.4	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.9	-0.7	-1.0	-1.7	0.7	-0.4	-0.6	-1.3
Age at first live birth	0.6	1.1	3.8	-0.8	-1.3	0.4	-0.8	-0.8	-0.5	-2.0
Pulse wave peak to peak time	1.9	2.2	7.8	-0.1	-1.7	-1.1	2.8	-1.6	-0.9	0.0
Health satisfaction	0.7	0.9	2.8	0.9	-0.4	-1.0	-0.5	-0.2	-1.7	-1.3
Shortness of breath walking on level ground	0.4	0.5	1.6	-1.2	0.3	0.1	-0.9	0.8	-0.6	-0.1
Qualifications: College or University degree	0.8	2.4	8.4	-0.7	-2.4	0.5	0.2	-1.3	0.3	-2.9
Eye problems/disorders: None of the above	1.2	1.3	4.1	0.5	0.5	1.7	-1.2	-0.3	2.0	0.6
Mouth/teeth dental problems: Loose teeth	3.0	3.5	7.2	1.4	1.8	2.7	-2.3	1.5	1.9	1.0
Emphysema/chronic bronchitis	0.9	1.0	4.2	2.1	-0.4	1.1	-0.1	-0.7	-0.4	-0.7
Medication for pain relief, constipation, heartburn	0.7	1.3	3.8	-0.3	0.9	1.3	-0.3	-0.3	1.6	1.9
Neck or shoulder pain in last month	0.4	0.6	2.0	-0.8	0.6	-0.4	-0.8	1.4	0.4	0.2
Medication: Blood pressure	1.2	2.1	5.5	1.9	1.2	1.6	-2.3	0.3	0.4	-1.3
Angina (self-reported)	0.3	0.4	1.2	1.1	0.8	0.5	-0.6	0.6	0.3	0.3
Migraine (self-reported)	2.6	3.2	6.1	-0.6	-2.5	-1.3	2.4	-2.0	-1.6	-1.4
Medication: Ibuprofen	1.1	1.3	2.5	0.4	-1.3	-0.7	0.6	-1.4	-1.6	-1.3
Medication: Allopurinol	0.1	0.2	0.7	-0.0	-0.4	0.2	-0.5	-0.3	0.8	-0.3
Medication: Omeprazole	0.2	0.2	0.4	-0.5	0.3	-0.3	-0.6	0.6	-0.0	0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.8	0.7	0.1	0.3	-0.5	-0.6	-0.2	-0.9
Mean time to correctly identify matches	1.0	1.9	4.6	0.1	-0.0	-2.1	2.1	0.0	-1.5	1.4
Heart disease (mother)	0.4	0.5	1.2	0.1	-0.1	-1.0	0.3	0.4	-1.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.3	0.9	0.4	-0.6	1.0	-0.3	-0.5	1.5
Whole body fat mass	0.7	2.8	10.2	-0.2	1.0	-0.9	-3.2	1.5	-2.0	-1.1
Leg fat mass (right)	1.0	3.8	12.2	1.2	2.3	-0.4	-3.5	2.3	-1.4	0.6
Arm predicted mass (right)	0.3	1.7	3.9	1.9	0.9	-0.4	-1.4	2.0	-0.9	0.6
Pulse rate, automated reading	0.3	1.1	2.7	1.0	0.8	-0.8	0.5	1.2	-1.0	1.6
Alcohol intake frequency.	0.4	0.9	1.8	-1.4	1.1	-0.2	-0.8	1.2	0.5	1.1
Comparative height size at age 10	0.9	4.8	15.7	-1.1	-3.2	-0.8	0.3	-1.3	-1.9	-4.0
Number of full sisters	0.3	0.4	1.3	-1.1	0.0	-0.5	-0.5	0.5	-0.6	-0.5
Suffer from ‘nerves’	0.4	0.6	2.9	-1.7	-0.6	-0.2	-0.4	-0.8	0.6	-0.1
Overall health rating	0.6	1.4	3.3	-0.6	-0.5	-0.9	-1.3	-0.1	-1.8	-1.8
Chest pain or discomfort	0.2	0.2	1.0	-0.0	-0.2	-0.4	0.1	0.1	-0.6	-1.0
Had major operations	0.7	0.8	1.8	1.2	-0.5	-1.0	0.4	-0.1	-1.3	-0.8
Age at last live birth	1.6	2.3	7.0	-0.9	-2.1	-0.4	-0.1	-1.5	-1.2	-2.6
Family relationship satisfaction	0.9	1.2	2.7	-1.6	-0.4	-1.6	0.4	-0.3	-1.5	-0.7
Leg pain on walking	0.5	0.6	2.0	-0.0	0.9	0.2	-0.0	1.1	0.5	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.7	0.3	0.4	0.1	1.0	0.7	0.2	1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	1.3	0.3	0.5	0.4	-0.7	0.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.5	-1.6	-0.1	-0.3	0.0	0.7	0.6	-0.1
Medication: Aspirin	0.2	0.3	1.5	-0.1	-0.3	0.3	0.1	0.6	0.0	-1.2
Supplements: Vitamin C	0.5	0.6	1.4	1.1	0.1	-0.8	0.3	-1.2	-0.3	0.8
Knee pain experienced in last month	0.5	0.7	1.8	-1.3	0.0	-0.3	-1.2	0.1	-0.9	-1.1
Hypertension (Self-reported)	0.7	1.9	5.3	1.6	0.2	-0.6	-1.6	-0.7	-1.5	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	0.2	1.1	-0.3	-0.3	0.5	0.2	0.9
Illnesses of father: Heart disease	0.1	0.2	1.0	0.3	0.0	-0.2	-0.4	-0.1	0.1	-1.0
Illnesses of siblings: Diabetes	1.9	2.3	9.6	3.1	0.9	0.9	-1.8	0.5	1.2	-0.0
Smoking status: Previous	0.2	0.3	0.7	0.4	0.6	-0.8	-0.3	0.5	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	5.3	-1.1	-2.3	0.3	0.9	-2.2	-1.4	-2.3
Whole body fat-free mass	0.2	1.4	3.3	1.8	0.5	-0.1	-1.8	1.5	-0.9	-0.0
Leg fat-free mass (right)	0.2	1.1	3.0	0.8	-0.3	-1.1	-1.2	1.0	-1.7	-0.9
Arm fat percentage (left)	0.8	3.4	10.7	-0.1	1.5	-1.6	-3.3	1.9	-2.1	-0.5
Average weekly red wine intake	0.3	0.4	1.1	1.0	0.2	-0.8	0.6	0.5	-0.3	0.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.2	-0.7	-1.1	-1.5	-0.4	-0.9	-0.6	-1.3
Mood swings	0.2	0.4	2.0	0.5	0.1	-0.1	-0.4	0.1	-1.4	0.4
Loneliness, isolation	1.3	1.8	5.4	1.1	1.9	0.2	-1.1	0.7	0.6	2.3
Long-standing illness, disability or infirmity	0.4	0.6	2.2	0.3	0.9	-0.1	-1.5	1.1	-0.3	-0.2
Ever had bowel cancer screening	1.4	1.6	4.0	0.6	0.0	2.0	-1.8	0.4	1.9	-0.4
Diabetes diagnosed by doctor	1.6	2.6	4.5	2.0	2.0	0.6	-1.4	2.1	1.4	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.7	-0.1	-0.1	1.6	-0.8	0.7	1.1	0.1
Friendships satisfaction	0.5	0.6	1.7	-0.3	-1.1	-1.0	0.5	0.0	-0.1	-1.3
Qualifications: nursing, teaching	1.9	2.9	7.0	2.2	1.4	2.6	-1.3	1.1	1.9	0.5
Commuting to job workplace: Walk	0.5	0.6	2.2	-0.4	-0.2	-0.5	1.5	-0.0	-0.8	0.9
Eye problems/disorders: Cataract	0.8	0.9	3.4	0.1	-0.2	-1.3	1.9	0.4	-0.9	0.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.7	-2.2	0.5	1.5	-0.8	1.1	1.4	0.3
Medication for cholesterol	0.5	0.8	3.2	0.3	0.1	1.8	-0.1	0.9	0.9	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.2	0.1	1.6	0.2	-1.4	2.0	0.5	0.8
Back pain experienced in last month	0.2	0.3	1.2	-0.6	-0.0	1.1	-0.3	-0.2	0.6	-0.2
Mineral and other dietary supplements	0.9	1.3	3.5	0.1	1.1	0.7	0.1	1.9	1.1	1.6
Breast cancer (self-reported)	0.1	0.1	0.6	-0.3	0.1	0.3	-0.5	0.8	0.1	-0.1
Asthma (self-reported)	0.3	0.6	2.8	-0.6	-0.4	0.0	1.7	-0.8	-0.5	0.1
Osteoporosis (self-reported)	3.8	4.7	12.3	-2.1	-2.6	-0.6	0.4	-1.9	-2.3	-3.5
Osteoarthritis (self-reported)	0.4	0.5	1.5	0.6	-0.9	-0.5	-0.5	-0.7	-0.1	-1.2
Medication: Aspirin	0.4	0.6	1.4	0.4	0.2	0.7	-0.7	1.1	0.5	-1.2
Medication: Gliclazide	0.3	0.4	1.8	-1.4	-0.3	-0.5	-0.0	0.2	0.4	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.4	1.6	0.6	0.4	0.0	0.5	-0.5	0.4	1.3
Smoking status: Current	3.0	4.7	9.4	0.8	3.1	0.9	-2.4	2.8	0.9	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	-0.2	0.7	0.0	1.1	0.5	0.3	1.1
Whole body water mass	0.3	1.5	3.5	1.8	0.7	-0.1	-1.9	1.7	-0.9	0.1
Leg predicted mass (right)	0.2	1.2	3.1	0.8	-0.2	-1.2	-1.2	1.0	-1.8	-0.9
Arm fat mass (left)	0.8	3.4	10.3	0.5	1.5	-1.4	-3.2	2.2	-2.0	-0.4
Number of self-reported non-cancer illnesses	0.9	1.6	4.5	0.9	-0.6	-1.7	0.2	-0.7	-2.1	-1.5
Average weekly champagne plus white wine intake	1.4	1.9	6.1	0.7	-1.0	2.5	-1.0	-0.7	1.0	-1.8
Miserableness	0.8	1.3	3.8	1.9	1.2	-0.2	-0.8	0.6	-0.7	1.6
Guilty feelings	0.3	0.5	2.4	0.4	-0.1	-0.3	-0.6	-0.3	-1.6	0.1
Wears glasses or contact lenses	0.4	0.5	1.2	1.1	0.4	-0.6	-0.6	1.0	-0.3	-0.6
Ever taken oral contraceptive pill	2.3	2.6	9.0	3.0	1.3	1.9	-1.2	-0.2	0.5	1.3
Hearing aid user	1.8	2.0	6.5	-0.4	-1.1	-1.2	0.5	-1.0	-1.9	-2.5
Mother’s age at death	0.8	0.9	2.3	-1.1	0.7	0.2	-1.5	1.4	0.6	-0.1
Financial situation satisfaction	0.6	0.7	3.0	-1.7	0.3	-0.9	0.1	0.8	-0.6	0.6
Tinnitus: Yes, now most or all of the time	3.7	4.4	14.9	-0.5	-1.0	-3.9	1.7	-0.7	-3.3	-0.1
Commuting to job workplace: Public transport	0.6	0.8	2.5	-0.7	-1.3	0.2	0.7	-0.3	0.0	-1.6
Eye problems/disorders: Glaucoma	1.6	1.9	5.0	-1.4	-0.6	-1.9	1.2	-0.7	-2.2	-0.7
Medication: Blood pressure	0.5	1.0	3.5	0.5	-0.4	-0.9	-0.7	-1.1	-1.0	-1.9
Pain type(s) experienced in last month: Hip pain	1.7	2.1	3.2	-1.7	-1.8	-1.2	1.3	-0.4	-1.7	-1.5
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.5	-0.5	-1.2	-1.1	1.1	-2.1	-1.6	-0.9
High cholesterol (Self-reported)	3.5	6.3	14.9	-1.2	-1.9	-3.9	3.2	-1.9	-2.9	-1.4
Medication: Bendroflumethiazide	1.6	2.4	5.4	2.1	1.7	1.8	-2.3	0.5	1.0	-0.0
Medication: Paracetamol	1.4	2.2	5.8	0.1	-1.4	-1.4	0.6	-1.2	-2.0	-2.4
Medication: Lisinopril	0.6	0.8	2.8	-1.2	0.4	0.9	0.0	0.2	1.7	0.4
Medication: Atorvastatin	0.6	0.7	2.2	0.1	0.2	-1.5	1.2	-0.1	-1.0	0.3
Illnesses of father: High blood pressure	0.4	0.4	1.4	-1.2	-0.1	-0.3	-0.5	0.2	-0.8	-0.8
Alcohol drinker status: Never	0.8	1.0	1.7	-1.1	1.0	-1.3	0.4	1.0	-0.7	1.2
Ever smoked	1.0	1.8	4.8	0.8	1.6	-0.3	-1.3	1.5	0.5	2.2
Basal metabolic rate	0.3	1.7	4.8	1.6	0.7	-0.2	-2.2	1.6	-1.1	-0.1
Leg fat percentage (left)	1.8	6.6	16.7	1.3	3.7	-0.2	-4.1	3.2	-0.8	1.7
Arm fat-free mass (left)	0.4	1.9	4.2	1.8	1.1	-0.4	-2.0	2.0	-0.8	0.5
Number of operations (self-reported)	1.5	2.2	7.5	1.8	0.9	-0.2	-2.7	1.4	-0.7	-1.1
Average weekly beer plus cider intake	0.5	0.7	2.6	-0.1	0.9	-0.6	-0.8	0.5	-0.4	1.6
Irritability	0.7	1.2	3.4	1.7	0.4	-0.6	1.3	-0.5	-0.5	1.8
Risk taking	0.3	0.5	2.6	-1.6	-0.5	-0.6	-0.0	-0.2	-0.4	-0.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	-1.3	0.0	0.0	-1.2	1.3	0.8	0.1
Fractured/broken bones in last 5 years	1.6	2.1	4.1	1.5	1.0	1.9	-2.0	1.4	1.0	-0.6
Age started oral contraceptive pill	1.0	1.2	3.5	1.9	1.3	0.7	-1.3	0.7	0.2	0.7
Diastolic blood pressure, automated reading	0.3	0.8	2.2	1.5	0.8	-0.1	-0.2	0.0	-1.5	0.7
Ever depressed for a whole week	0.9	1.1	2.9	-0.1	-1.3	-0.9	0.9	-0.8	-1.0	-1.7
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.2	0.7	1.0	-0.8	0.5	-0.2	-0.4
Commuting to job workplace: Cycle	2.0	2.4	6.1	1.9	1.3	2.5	-0.3	0.9	1.3	1.7
Myopia	0.7	1.0	2.0	-1.1	-0.3	0.7	-1.3	-0.2	1.1	-1.4
Vascular/heart problems diagnosed by doctor	0.5	1.5	4.0	-1.4	0.0	0.8	0.9	0.5	1.6	2.0
Cholesterol lowering medication	1.0	1.5	5.0	0.5	-0.8	-2.2	1.0	-0.9	-1.6	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.6	0.2	0.4	-0.2	-0.1	0.8	0.1	0.5
Pain experienced in last month	0.3	0.6	2.7	1.6	0.0	0.0	0.5	-0.8	-0.1	-0.5
Supplements: Calcium	0.8	0.9	2.0	-0.1	-1.4	-0.7	0.7	-1.2	-0.6	-1.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.5	0.1	0.1	-0.6	-0.1	1.2	-0.1	-0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.8	1.7	0.3	0.9	0.8	0.2	0.3	0.8
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.1	-2.2	-0.8	-0.9	1.5	1.0	-0.4	-0.0
Heart disease (siblings)	1.1	1.4	3.4	-0.3	-0.1	-1.8	1.7	-0.1	-1.8	0.3
Alcohol drinker status: Previous	1.2	1.4	4.3	-0.0	1.2	0.8	-2.1	1.5	0.9	0.2
Pack years of smoking	1.0	1.5	2.8	1.7	1.5	0.4	-0.9	1.6	0.7	1.3
Impedance of whole body	2.3	11.7	23.7	-4.4	-4.3	1.1	1.4	-4.0	-1.1	-4.9
Leg fat mass (left)	1.1	4.3	12.4	1.2	2.6	-0.4	-3.5	2.7	-1.2	0.9
Arm predicted mass (left)	0.4	2.1	4.3	1.9	1.2	-0.2	-2.1	2.0	-0.6	0.5