Hub : Genes

SKAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.127 0.0256 0.0e+00 0.071 0.144 0.138 0.146 0.133 2.5e-22 1.2e-44 6.9e-43 2.1e-45 2.9e-41
2 TCGA Thyroid Carcinoma 0.165 0.0600 7.4e-06 0.067 0.059 0.063 NA 0.066 4.5e-07 2.1e-06 8.7e-07 NA 4.8e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.0 1.5 2.9 1.7 0.3
Bipolar Disorder or Schizophrenia 0.3 0.7 1.1 1.0 -0.5
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 -0.7 0.0
Depression (Nagel 2018) 0.6 0.9 1.6 -0.3 1.3
Intelligence (Savage-Jansen 2018) 0.0 0.0 0.1 0.2 -0.2
Neuroticism (Nagel 2018) 0.3 0.8 0.8 0.9 0.9
Schizophrenia (2018) 0.2 0.4 0.7 -0.1 -0.9
Schizophrenia vs Biploar Disorder 0.7 0.9 1.6 -0.4 -1.2
Worry (Nagel 2018) 0.8 1.7 2.4 1.5 1.1
Alzheimer’s Disease (in mother) 0.4 0.4 0.8 -0.9 -0.2
Alzheimer’s Disease (in father) 0.6 0.6 1.3 0.1 -1.1
Alzheimer’s Disease (including proxy) 0.5 0.7 1.2 -0.5 -1.1
Crohns Disease (2017) 2.4 5.3 10.0 3.2 0.7
Irritable Bowel Disease (IBD) 2.1 5.0 9.9 3.1 0.3
Ulcerative Colitis (UC) 1.6 3.0 6.0 2.4 -0.1
Major Depression (MDD) 0.5 0.6 0.8 -0.9 -0.7
Reaction Time 0.7 1.3 2.6 1.6 -0.1
Verbal and Numeric Reasoning (VNR) 0.0 0.0 0.1 -0.2 -0.1
Breast Cancer 0.9 2.1 4.2 -0.3 -2.0
Ovarian Cancer 5.3 7.1 11.8 3.4 -1.5
Prostate Cancer 1.4 2.0 2.6 -1.6 -1.2
Age at First Birth 0.0 0.0 0.1 -0.3 -0.1
Bipolar Disorder (2011) 1.3 1.2 2.0 1.4 0.7
Body Mass Index (BMI) (2010) 0.7 1.0 2.0 -0.1 -1.4
Coronary Artery Disease (CAD) 2.7 3.2 3.9 1.6 2.0
Crohns Disease (2012) 1.9 3.0 6.0 2.4 0.2
Mean Putamen Volume 0.2 0.2 0.3 -0.3 -0.6
Fasting Glucose 0.8 1.0 1.5 -0.7 -1.2
HbA1C 0.5 0.6 1.2 0.1 1.1
HDL Cholesterol 0.1 0.1 0.2 0.4 -0.3
LDL Cholesterol 3.4 5.4 10.7 3.3 -0.2
Lupus 1.8 2.8 2.9 1.6 -1.7
Neuroticism (2016) 0.0 0.1 0.1 -0.2 0.3
Primary Biliary Cirrhosis 2.1 2.9 5.8 2.4 -0.3
Rheumatoid Arthritis 0.0 0.1 0.1 -0.3 -0.1
Schizophrenia (2014) 0.4 0.8 1.4 -0.4 -1.2
Triglycerides 0.0 0.1 0.1 -0.3 0.0
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.7 -0.5 -0.8
Ulcerative Colitis 0.5 0.8 1.2 0.6 -1.1
Blood Eosinophil Count 0.4 3.0 5.8 -2.4 0.6
Blood Platelet Count 0.1 0.9 1.3 -1.1 0.8
Blood Red Count 3.7 35.4 70.6 8.4 -0.4
Blood White Count 2.0 14.8 29.1 -5.4 0.7
Heel T-Score 0.6 4.4 8.8 -3.0 -0.3
BMI 0.1 0.8 1.5 -1.2 -0.4
Height 0.1 2.2 4.2 -2.1 0.5
Waist Hip Ratio (WHR) 0.4 1.8 3.5 0.2 -1.9
Systolic Blood Pressure 0.7 3.7 7.1 0.6 2.7
Smoking Status 1.5 3.6 6.8 -2.6 0.5
Allergy or Eczema 0.2 0.5 0.6 0.6 0.8
Cardiovascular Disease 5.0 16.5 19.9 3.6 4.5
Hypothyroidism (self reported) 1.3 2.9 3.0 1.7 1.7
Respiratory disease 2.3 5.1 8.4 2.9 -1.3
Type 2 Diabetes (T2D) (2018) 1.0 2.0 3.8 -2.0 -0.3
Lung FEV1/FVC ratio 2.1 10.7 17.3 -2.0 4.2
Lung FVC 3.3 16.9 29.3 5.4 2.1
Neuroticism 0.2 0.6 0.9 1.0 0.5
Chronotype (morning person) 1.5 3.4 4.4 1.6 2.1
Hair Pigment 1.1 30.5 59.6 -7.7 1.2
Tanning 0.0 0.6 1.1 1.0 0.3
Hand grip strength (left) 6.3 16.5 26.5 5.1 2.5
Number of treatments/medications taken 1.8 3.2 4.7 2.2 1.3
Average weekly spirits intake 2.6 3.2 3.6 1.9 1.6
Sensitivity / hurt feelings 0.2 0.3 0.3 0.5 0.5
Frequency of depressed mood in last 2 weeks 0.4 0.6 0.8 0.6 0.9
Hearing difficulty/problems: Yes 3.1 4.7 9.4 3.1 -0.0
Relative age of first facial hair 0.6 1.2 1.5 -1.2 -0.9
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 -0.8 0.3
Ever used hormone-replacement therapy (HRT) 2.9 3.7 6.2 -2.5 -1.0
Ever had hysterectomy (womb removed) 0.6 0.7 1.3 -1.1 0.3
Systolic blood pressure, automated reading 0.3 0.8 1.6 -0.1 1.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 0.7 0.0
Angina 1.2 1.6 2.8 0.5 1.7
Medication for hormone replacement therapy 2.3 2.5 2.8 -1.5 -1.7
Vitamin and mineral supplements 0.5 0.6 0.7 -0.7 0.8
Supplements: Zinc 0.3 0.4 0.6 -0.8 -0.3
Medication: Co-codamol 0.5 0.6 1.1 -0.5 -1.0
Medication: Metformin 1.0 1.4 2.7 -1.6 -0.5
Diabetes (father) 0.4 0.6 0.9 0.5 0.9
Diabetes (mother) 1.4 1.8 2.9 -1.7 -0.9
Severe depression (siblings) 1.4 1.6 2.2 -1.5 1.0
Pack years adult smoking proportion 0.1 0.2 0.3 0.4 0.6
Impedance of leg (right) 0.4 1.8 3.6 -1.9 0.1
Leg fat-free mass (left) 0.0 0.1 0.2 0.1 0.4
Trunk fat percentage 0.8 3.4 3.8 -1.9 -1.7
Hand grip strength (right) 5.7 15.6 25.8 5.1 2.3
Townsend deprivation index at recruitment 1.1 1.6 1.9 -1.1 -1.4
Current tobacco smoking 0.8 1.4 2.7 -1.6 0.1
Average weekly fortified wine intake 0.3 0.3 0.7 0.8 0.2
Maternal smoking around birth 1.8 2.6 4.9 -2.2 -0.4
Fed-up feelings 0.0 0.1 0.2 0.1 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 3.3 0.2 1.8
Relative age voice broke 0.1 0.2 0.3 0.3 -0.5
Taking other prescription medications 0.6 0.9 1.0 1.0 0.9
Age when periods started (menarche) 0.7 1.8 2.2 1.5 1.2
Bilateral oophorectomy (both ovaries removed) 3.8 4.4 7.0 -2.6 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.2 0.3 0.4
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.0 0.1 0.2
Qualifications: CSEs or equivalent 1.8 2.3 4.7 -0.1 2.2
Serious illness, injury or assault to yourself 1.0 1.2 2.1 0.6 1.4
High blood pressure 1.8 5.1 5.6 2.4 2.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.6 1.2 -0.2
Multivitamins +/- minerals 0.4 0.6 1.1 0.2 -1.1
Stomach or abdominal pain in last month 0.5 0.7 1.0 -1.0 0.6
Supplements: Glucosamine 1.0 1.3 2.1 -0.7 -1.4
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 4.9 -0.2 2.2
Medication: Atenolol 2.3 2.9 3.9 1.4 2.0
Medication: Levothyroxine sodium 1.1 1.9 3.7 1.9 0.4
Sitting height 0.1 0.5 0.8 -0.4 0.9
Chronic bronchitis/emphysema (father) 4.1 4.8 9.6 -3.1 -0.3
High blood pressure (mother) 4.8 6.7 7.1 2.5 2.7
Body mass index (BMI) 0.1 0.6 0.6 -0.8 -0.8
Impedance of leg (left) 0.4 1.8 3.5 -1.9 0.2
Leg predicted mass (left) 0.0 0.1 0.2 0.2 0.5
Trunk fat mass 0.7 2.9 4.2 -2.0 -1.3
Waist circumference 0.2 0.8 1.0 -1.0 -0.8
Number of incorrect matches in round 0.0 0.0 0.0 0.1 -0.1
Past tobacco smoking 1.2 2.3 4.4 2.1 0.4
Alcohol usually taken with meals 0.4 0.6 0.8 0.6 0.9
Nervous feelings 1.5 2.8 3.7 1.9 1.4
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.3 5.1 1.3 2.2
Hearing difficulty/problems with background noise 2.0 3.2 6.4 2.5 0.1
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 -0.6 -0.1
Had menopause 3.5 4.3 5.0 -1.9 -2.2
Had other major operations 0.3 0.4 0.4 -0.7 -0.6
Forced vital capacity (FVC) 1.8 6.9 10.6 3.2 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.5 0.2 0.7
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.3 -0.6 -0.4
Qualifications: None of the above 0.1 0.2 0.2 -0.5 -0.4
Financial difficulties in last 2 years 2.2 3.0 5.8 -0.3 2.4
Mouth/teeth dental problems 0.2 0.3 0.4 0.5 -0.6
Heart attack 3.1 4.0 6.0 1.4 2.4
Allergy 1.7 3.9 7.6 -2.8 -0.4
Pain all over the body in last month 0.7 0.7 0.8 0.9 0.8
Diabetes (self-reported) 0.1 0.2 0.4 -0.6 -0.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 0.6 -0.2
Medication: Ramipril 1.4 1.8 3.5 1.9 0.3
Medication: Simvastatin 8.0 11.8 20.1 4.5 1.9
Fluid intelligence score 0.1 0.2 0.5 -0.0 -0.7
Illnesses of siblings 0.3 0.4 0.7 -0.9 0.1
Neuroticism score 0.5 1.0 1.7 1.3 0.6
Weight 0.2 0.9 1.7 -1.3 -0.1
Impedance of arm (right) 0.3 1.2 1.7 -0.8 -1.3
Arm fat percentage (right) 0.6 2.2 2.6 -1.3 -1.6
Trunk fat-free mass 0.1 0.6 0.8 -0.6 0.9
Hip circumference 0.1 0.4 0.8 -0.9 0.3
Time employed in main current job 0.1 0.1 0.1 -0.4 0.0
Alcohol intake versus 10 years previously 0.1 0.1 0.2 0.4 0.2
Father’s age at death 1.4 1.9 3.5 -1.9 0.5
Worrier / anxious feelings 0.4 0.8 1.4 1.2 0.3
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 4.2 -0.1 2.1
Falls in the last year 0.6 0.8 1.1 -1.1 0.7
Hair/balding pattern: Pattern 3 4.8 7.2 12.1 1.5 3.5
Number of live births 1.7 2.4 2.5 -1.5 -1.6
Forced expiratory volume in 1-second (FEV1) 3.0 10.2 10.6 3.2 3.1
Pulse rate 1.4 2.4 2.7 1.5 1.6
Happiness 2.2 2.6 5.1 2.3 -0.3
Noisy workplace 0.4 0.5 0.9 0.3 1.0
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.9 0.1 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.6 -0.5 0.8
Mouth/teeth dental problems: Dentures 0.7 1.2 2.3 1.5 0.3
Asthma 3.5 6.9 11.6 3.4 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 0.1 0.8
Medication: Cholesterol lowering 6.2 9.6 18.4 4.3 0.9
Depression (self-reported) 0.8 1.0 1.8 -0.2 1.4
Medication: Lansoprazole 1.5 1.7 3.0 -0.6 1.7
Prospective memory result 0.5 0.6 0.9 -0.5 -1.0
Lung cancer (father) 0.7 0.8 1.2 -1.1 -0.6
Illnesses of mother 1.3 1.6 3.1 0.3 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 4.8 15.4 16.5 3.8 4.1
Pulse wave Arterial Stiffness index 0.1 0.2 0.2 -0.3 0.5
Impedance of arm (left) 0.2 0.9 1.6 -0.4 -1.3
Arm fat mass (right) 0.4 1.7 1.9 -1.4 -1.2
Trunk predicted mass 0.1 0.6 0.9 -0.6 1.0
Standing height 0.1 1.4 1.5 -1.2 1.2
Length of working week for main job 0.1 0.1 0.2 -0.4 -0.3
Exposure to tobacco smoke at home 0.2 0.2 0.4 -0.2 -0.7
Breastfed as a baby 0.6 0.7 1.4 -1.2 -0.2
Tense / ‘highly strung’ 2.1 3.5 3.8 2.0 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.1 -0.3 -0.3
Hair/balding pattern: Pattern 4 0.4 0.9 1.0 -1.0 -0.9
Birth weight of first child 2.8 5.0 7.5 -1.6 -2.7
Peak expiratory flow (PEF) 2.2 5.1 5.6 -2.1 2.4
Pulse wave reflection index 0.2 0.3 0.3 -0.6 0.5
Ever highly irritable/argumentative for 2 days 1.1 1.3 1.9 -0.9 -1.4
Loud music exposure frequency 3.0 3.2 4.1 -1.6 -2.0
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 0.6 0.2
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 1.2 -0.8 1.1
Blood clot in the leg (DVT) 1.8 2.3 3.8 0.9 2.0
Medication: Paracetamol 0.3 0.5 0.5 0.7 0.7
Headache pain in last month 0.1 0.1 0.3 0.5 -0.0
Medication for cholesterol, blood pressure or diabetes 2.7 4.5 7.1 -2.7 -1.4
Glaucoma (self-reported) 1.4 1.7 2.7 1.6 0.8
Gout (self-reported) 0.2 0.2 0.4 -0.7 0.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 1.3 1.1 1.0
Medication: Amlodipine 1.3 1.8 3.3 0.6 1.8
Medication: Ventolin 100micrograms inhaler 0.8 1.0 1.4 0.8 -1.2
Birth weight 0.2 0.4 0.8 -0.2 -0.9
Chronic bronchitis/emphysema (mother) 3.1 3.6 5.9 -2.4 1.2
High blood pressure (siblings) 0.2 0.3 0.6 0.8 0.1
Forced vital capacity (FVC), Best measure 3.0 11.0 16.0 4.0 2.4
Body fat percentage 0.8 3.0 4.4 -2.1 -1.3
Leg fat percentage (right) 0.9 3.3 6.2 -2.5 -0.6
Arm fat-free mass (right) 0.1 0.6 1.1 -0.4 1.1
Exposure to tobacco smoke outside home 0.9 1.2 1.3 1.1 -1.1
Comparative body size at age 10 0.9 2.4 3.3 -1.8 -1.2
Number of full brothers 1.0 1.2 1.7 1.3 0.9
Worry too long after embarrassment 3.1 5.2 6.9 2.6 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.5 0.2
Wheeze or whistling in the chest in last year 0.7 1.3 2.5 1.6 0.4
Number of children fathered 0.8 0.9 0.9 0.9 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 1.8 -1.4 -1.0
Age at first live birth 0.5 0.9 1.7 1.3 -0.2
Pulse wave peak to peak time 0.1 0.1 0.2 0.2 -0.4
Health satisfaction 1.4 1.8 3.0 1.7 0.7
Shortness of breath walking on level ground 1.8 2.2 4.3 0.1 2.1
Qualifications: College or University degree 0.2 0.5 0.8 0.4 0.9
Eye problems/disorders: None of the above 1.6 1.9 3.5 -1.9 -0.5
Mouth/teeth dental problems: Loose teeth 2.4 2.9 4.0 -2.0 1.3
Emphysema/chronic bronchitis 0.2 0.2 0.5 -0.7 0.1
Medication for pain relief, constipation, heartburn 1.0 1.8 2.5 -1.0 -1.6
Neck or shoulder pain in last month 1.0 1.4 1.8 -1.0 1.3
Medication: Blood pressure 1.2 2.2 3.5 0.9 1.9
Angina (self-reported) 0.9 1.2 2.2 0.4 1.5
Migraine (self-reported) 2.2 2.8 3.1 1.8 1.6
Medication: Ibuprofen 0.1 0.1 0.2 0.5 0.1
Medication: Allopurinol 0.3 0.4 0.5 -0.5 -0.7
Medication: Omeprazole 1.0 1.2 1.6 -1.3 -0.9
Medication: Seretide 50 evohaler 0.9 1.0 1.8 -0.4 -1.3
Mean time to correctly identify matches 0.6 1.2 2.5 1.6 0.0
Heart disease (mother) 1.8 2.1 2.5 1.3 1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 2.3 1.5 1.5
Whole body fat mass 0.6 2.5 3.7 -1.9 -1.1
Leg fat mass (right) 0.5 1.8 3.4 -1.8 -0.4
Arm predicted mass (right) 0.1 0.4 0.7 -0.3 0.8
Pulse rate, automated reading 2.8 9.0 10.4 3.2 2.8
Alcohol intake frequency. 0.5 1.2 2.3 -1.5 -0.3
Comparative height size at age 10 0.2 0.8 1.7 0.1 -1.3
Number of full sisters 0.5 0.6 1.2 0.0 1.1
Suffer from ‘nerves’ 0.8 1.3 2.5 -1.6 0.4
Overall health rating 0.5 1.1 1.6 1.3 0.8
Chest pain or discomfort 0.5 0.7 0.8 0.9 0.7
Had major operations 1.5 1.8 2.9 1.7 -0.8
Age at last live birth 1.1 1.6 3.1 1.8 0.3
Family relationship satisfaction 0.9 1.1 2.3 1.5 0.1
Leg pain on walking 1.1 1.4 1.6 -1.3 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.1 0.5 1.0
Commuting to job workplace: Car/motor vehicle 2.8 3.2 4.9 1.2 2.2
Illness, injury, bereavement, stress in last 2 years 2.9 3.5 7.0 0.0 -2.6
Medication: Aspirin 3.4 4.5 5.5 1.9 2.3
Supplements: Vitamin C 0.4 0.4 0.9 0.9 -0.0
Knee pain experienced in last month 0.4 0.7 1.1 -0.4 -1.1
Hypertension (Self-reported) 2.1 5.8 6.6 2.6 2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 -0.3 0.8
Illnesses of father: Heart disease 0.4 0.6 1.1 1.0 -0.3
Illnesses of siblings: Diabetes 1.0 1.3 1.9 -0.8 -1.4
Smoking status: Previous 0.6 0.9 1.7 -1.3 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.2 1.1 1.0
Whole body fat-free mass 0.0 0.3 0.5 -0.2 0.7
Leg fat-free mass (right) 0.0 0.3 0.3 0.5 0.5
Arm fat percentage (left) 0.5 1.8 2.2 -1.2 -1.5
Average weekly red wine intake 0.3 0.5 0.8 -0.4 -0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.7 0.3 -0.8
Mood swings 0.2 0.4 0.6 0.4 -0.7
Loneliness, isolation 0.2 0.3 0.4 -0.6 0.6
Long-standing illness, disability or infirmity 0.2 0.3 0.5 -0.7 -0.1
Ever had bowel cancer screening 3.1 3.7 4.2 -2.0 -1.8
Diabetes diagnosed by doctor 0.2 0.4 0.8 -0.9 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.7 -0.8 0.6
Friendships satisfaction 1.2 1.4 2.8 1.7 0.3
Qualifications: nursing, teaching 1.3 2.0 4.0 -0.1 2.0
Commuting to job workplace: Walk 1.0 1.1 1.3 1.1 1.0
Eye problems/disorders: Cataract 1.4 1.6 2.9 1.7 0.5
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.4 -1.6 0.5
Medication for cholesterol 0.4 0.6 0.9 -1.0 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.3 -1.5 0.6
Back pain experienced in last month 2.3 3.4 6.6 -0.4 2.6
Mineral and other dietary supplements 0.5 0.7 1.2 -1.1 0.5
Breast cancer (self-reported) 0.9 1.1 2.2 0.2 1.5
Asthma (self-reported) 3.4 6.8 12.6 3.5 -1.0
Osteoporosis (self-reported) 0.3 0.3 0.6 0.8 -0.2
Osteoarthritis (self-reported) 0.1 0.1 0.3 -0.0 -0.5
Medication: Aspirin 1.7 2.3 3.5 1.1 1.9
Medication: Gliclazide 0.1 0.1 0.1 0.2 -0.3
Illnesses of father: None of the above (group 1) 0.9 1.1 1.4 0.9 -1.2
Smoking status: Current 1.5 2.3 4.6 -2.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.4 6.8 2.0 2.6
Whole body water mass 0.1 0.5 1.1 -0.1 1.0
Leg predicted mass (right) 0.0 0.2 0.3 0.5 0.4
Arm fat mass (left) 0.4 1.6 1.6 -1.3 -1.3
Number of self-reported non-cancer illnesses 2.2 3.9 7.1 2.7 0.8
Average weekly champagne plus white wine intake 0.9 1.2 1.9 -1.4 -0.8
Miserableness 0.1 0.1 0.1 -0.3 0.4
Guilty feelings 0.4 0.6 1.0 1.0 0.5
Wears glasses or contact lenses 1.0 1.1 2.1 0.4 -1.4
Ever taken oral contraceptive pill 0.2 0.2 0.3 -0.6 -0.2
Hearing aid user 0.7 0.8 1.5 1.2 0.4
Mother’s age at death 0.6 0.7 0.8 -0.8 -0.9
Financial situation satisfaction 1.0 1.3 1.3 1.1 1.1
Tinnitus: Yes, now most or all of the time 1.5 1.8 3.5 1.9 -0.1
Commuting to job workplace: Public transport 1.4 1.7 3.2 -0.3 -1.8
Eye problems/disorders: Glaucoma 0.9 1.1 2.2 1.5 -0.2
Medication: Blood pressure 0.4 0.7 1.3 1.1 -0.3
Pain type(s) experienced in last month: Hip pain 0.9 1.1 1.5 0.8 1.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 0.8 0.9 -0.8
High cholesterol (Self-reported) 7.9 14.0 22.7 4.8 2.3
Medication: Bendroflumethiazide 1.1 1.6 1.7 1.3 1.3
Medication: Paracetamol 0.5 0.8 1.6 1.3 0.1
Medication: Lisinopril 0.7 0.9 1.7 -0.4 1.3
Medication: Atorvastatin 1.7 2.1 2.6 1.6 1.3
Illnesses of father: High blood pressure 1.4 1.7 3.2 0.3 1.8
Alcohol drinker status: Never 0.9 1.1 2.0 -0.3 1.4
Ever smoked 0.8 1.4 2.5 -1.6 -0.4
Basal metabolic rate 0.0 0.3 0.3 -0.5 0.5
Leg fat percentage (left) 0.8 3.1 6.0 -2.4 -0.4
Arm fat-free mass (left) 0.1 0.6 0.7 -0.6 0.8
Number of operations (self-reported) 1.6 2.4 4.0 -0.9 -2.0
Average weekly beer plus cider intake 0.3 0.5 0.9 -0.9 -0.4
Irritability 0.2 0.4 0.8 0.9 0.1
Risk taking 1.0 1.5 1.8 -1.3 -1.1
Ever had prostate specific antigen (PSA) test 1.5 1.8 1.9 -1.4 -1.3
Fractured/broken bones in last 5 years 0.4 0.5 0.6 -0.7 0.8
Age started oral contraceptive pill 0.1 0.2 0.4 0.0 -0.6
Diastolic blood pressure, automated reading 4.4 13.7 13.7 3.7 3.7
Ever depressed for a whole week 0.9 1.1 1.5 1.2 -0.9
Unable to work because of sickness or disability 0.7 0.8 1.6 0.3 1.3
Commuting to job workplace: Cycle 0.6 0.7 1.0 -1.0 0.7
Myopia 0.4 0.6 0.6 -0.7 -0.8
Vascular/heart problems diagnosed by doctor 2.4 6.4 6.8 -2.5 -2.6
Cholesterol lowering medication 2.9 4.2 4.3 2.1 2.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.9 -1.0 -0.4
Pain experienced in last month 2.2 3.7 7.3 0.2 -2.7
Supplements: Calcium 0.7 0.8 1.4 1.2 0.5
Basal cell carcinoma (self-reported) 0.3 0.3 0.4 0.5 0.6
Heart attack/myocardial infarction (self-reported) 3.9 5.1 7.9 1.5 2.8
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 2.2 0.5 1.5
Heart disease (siblings) 0.3 0.4 0.4 0.6 0.7
Alcohol drinker status: Previous 2.2 2.5 4.4 -2.1 0.8
Pack years of smoking 0.0 0.0 0.0 0.1 0.1
Impedance of whole body 0.1 0.7 0.8 -0.9 -0.8
Leg fat mass (left) 0.5 1.9 3.6 -1.9 -0.4
Arm predicted mass (left) 0.1 0.5 0.6 -0.8 0.7