Best TWAS P=1.11e-25 · Best GWAS P=9.86e-28 conditioned to 0.000138
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | POMGNT2 | 0.21 | 0.16 | lasso | 5 | 0.16 | 2.3e-05 | -4.8 | -5.2 | 1.8e-07 | 0.51 | 0.32 | 0.17 | FALSE |
2 | GTEx | Brain Nucleus accumbens basal ganglia | POMGNT2 | 0.36 | 0.28 | lasso | 3 | 0.28 | 4.7e-08 | -5.1 | -5.3 | 1.4e-07 | 0.43 | 0.72 | 0.02 | FALSE |
3 | GTEx | Esophagus Muscularis | HIGD1A | 0.18 | 0.00 | enet | 41 | 0.04 | 9.8e-04 | -7.9 | -6.7 | 1.8e-11 | 0.66 | 0.05 | 0.92 | FALSE |
4 | GTEx | Lung | ZNF662 | 0.10 | 0.00 | lasso | 5 | 0.00 | 2.6e-01 | -10.9 | 10.4 | 1.6e-25 | -0.90 | 0.01 | 0.90 | FALSE |
5 | GTEx | Pituitary | CCDC13 | 0.34 | 0.10 | lasso | 4 | 0.18 | 2.6e-05 | -3.9 | -6.5 | 5.9e-11 | 0.37 | 0.07 | 0.30 | FALSE |
6 | METSIM | Adipose | ACKR2 | 0.05 | 0.02 | enet | 7 | 0.04 | 6.7e-07 | -9.2 | 7.1 | 1.3e-12 | -0.64 | 0.09 | 0.76 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | ACKR2 | 0.21 | 0.13 | lasso | 6 | 0.15 | 2.6e-18 | -9.4 | -8.6 | 1.1e-17 | 0.67 | 0.95 | 0.05 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf39 | 0.03 | 0.02 | blup | 50 | 0.03 | 9.7e-05 | -4.8 | 5.2 | 2.6e-07 | -0.43 | 0.01 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC13 | 0.03 | 0.03 | blup | 59 | 0.03 | 3.8e-04 | 3.6 | 5.5 | 2.8e-08 | -0.42 | 0.37 | 0.03 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CYP8B1 | 0.04 | 0.03 | blup | 45 | 0.04 | 1.3e-04 | -9.4 | 10.5 | 1.1e-25 | -0.85 | 0.02 | 0.93 | TRUE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | CYP8B1 | 0.04 | 0.01 | blup | 46 | 0.03 | 2.3e-04 | -9.4 | 9.0 | 1.8e-19 | -0.72 | 0.07 | 0.40 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | HHATL | 0.09 | 0.01 | enet | 11 | 0.02 | 3.1e-03 | 6.6 | -5.4 | 7.9e-08 | 0.31 | 0.01 | 0.91 | FALSE |