TWAS hub - CYP8B1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Prostate Adenocarcinoma	0.0361	0.0184	0.00034	0.027	0.035	0.024	NA	0.028	0.00076	0.00013	0.0013	NA	0.00053
2	TCGA	Thyroid Carcinoma	0.0410	0.0230	0.00089	0.010	0.035	0.027	NA	0.030	0.03500	0.00023	0.0010	NA	0.00064

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood White Count	12.9	95.9	110.2	10.5	9.0
Blood Eosinophil Count	12.8	98.5	114.5	10.7	9.1
Hair/balding pattern: Pattern 2	9.6	12.2	14.4	-3.8	-3.2
Illnesses of siblings	4.9	6.8	7.0	2.6	2.6
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	6.9	-1.5	-2.6
Osteoporosis (self-reported)	3.6	4.5	4.8	-2.2	-2.0
High blood pressure (siblings)	3.5	5.0	5.2	-2.2	-2.3
Unable to work because of sickness or disability	3.4	4.4	5.3	1.8	2.3
Diabetes (mother)	3.2	4.1	5.7	-1.5	-2.4
Birth weight of first child	3.2	5.8	6.9	-2.2	-2.6
Breast cancer (self-reported)	3.2	3.8	5.7	2.4	1.4
Major Depression (MDD)	3.1	3.7	3.8	-1.9	-1.9
Illnesses of siblings: Diabetes	3.1	3.8	6.0	-1.2	-2.5
Alzheimer’s Disease (in mother)	3.0	3.5	4.4	-1.6	-2.1
Stomach or abdominal pain in last month	3.0	3.7	4.0	1.8	2.0
Medication: Co-codamol	2.9	3.3	3.4	1.8	1.8
Had major operations	2.8	3.3	3.4	-1.8	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	4.3	2.1	1.7
Pulse rate, automated reading	2.7	8.7	10.2	-3.2	-2.7
Type 2 Diabetes (T2D) (2018)	2.6	4.9	5.0	-2.2	-2.2
Severe depression (siblings)	2.6	2.9	5.4	-0.7	-2.3
Financial difficulties in last 2 years	2.6	3.5	4.3	1.7	2.1
Knee pain experienced in last month	2.5	3.8	5.5	1.5	2.3
Friendships satisfaction	2.5	3.2	4.1	-1.5	-2.0
Depression (self-reported)	2.4	2.9	3.1	1.8	1.6
Average weekly beer plus cider intake	2.3	3.3	3.9	2.0	1.6
Pack years adult smoking proportion	2.2	3.3	3.3	1.8	1.8
Number of live births	2.2	3.2	3.7	1.6	1.9
Number of full brothers	2.2	2.8	4.1	-1.2	-2.0
Angina	2.1	2.7	3.8	1.9	1.3
Angina (self-reported)	2.1	2.8	3.7	1.9	1.4
High cholesterol (Self-reported)	2.1	3.7	4.1	-1.8	-2.0
Ever depressed for a whole week	2.0	2.4	2.8	-1.4	-1.7
Age at First Birth	1.9	2.8	3.7	-1.4	-1.9
Medication: Metformin	1.9	2.7	3.3	-1.4	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	2.9	1.1	1.7
Coronary Artery Disease (CAD)	1.8	2.2	3.2	-1.0	-1.8
Medication: Levothyroxine sodium	1.8	3.1	3.1	-1.8	-1.8
Mouth/teeth dental problems	1.8	2.7	2.8	-1.6	-1.7
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	3.8	-1.9	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	2.5	1.6	1.3
Noisy workplace	1.7	2.1	2.2	1.4	1.5
Number of children fathered	1.7	1.9	2.8	1.7	1.0
Leg pain on walking	1.7	2.1	2.7	1.2	1.6
Supplements: Vitamin C	1.7	2.0	3.5	-1.9	-0.7
Commuting to job workplace: Walk	1.7	1.8	2.7	-1.6	-1.0
Diabetes (self-reported)	1.6	2.4	3.4	-1.2	-1.9
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	3.0	-1.4	-1.7
Emphysema/chronic bronchitis	1.6	1.9	2.0	1.3	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.1	1.8	0.9
Age when periods started (menarche)	1.5	3.7	4.8	2.2	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.0	2.0	0.8
Time employed in main current job	1.5	1.8	2.9	-1.7	-0.8
Pack years of smoking	1.5	2.2	2.2	1.5	1.5
Systolic blood pressure, automated reading	1.4	4.0	4.4	-1.9	-2.1
Diabetes (father)	1.4	1.7	2.8	-0.8	-1.7
Qualifications: None of the above	1.4	3.0	3.3	1.6	1.8
Medication: Lansoprazole	1.4	1.6	2.3	1.0	1.5
Illnesses of mother	1.4	1.7	1.9	1.2	1.4
Hypothyroidism (self reported)	1.3	2.9	3.0	-1.7	-1.7
Average weekly fortified wine intake	1.3	1.5	2.0	1.4	1.0
Medication: Simvastatin	1.3	1.9	2.3	-1.3	-1.5
Asthma	1.3	2.5	3.0	-1.7	-1.4
Family relationship satisfaction	1.3	1.6	1.6	-1.2	-1.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.6	1.6	0.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.4	0.3	1.5
Glaucoma (self-reported)	1.2	1.4	1.7	1.3	1.0
Pulse wave peak to peak time	1.2	1.4	2.4	0.7	1.6
Had other major operations	1.1	1.4	1.6	1.1	1.3
Worrier / anxious feelings	1.1	2.0	2.7	-1.6	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.4	0.6	1.5
Qualifications: nursing, teaching	1.1	1.6	2.2	-1.5	-1.0
Alcohol intake versus 10 years previously	1.0	1.5	2.0	1.4	0.9
Pulse wave Arterial Stiffness index	1.0	1.2	2.0	-0.6	-1.4
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.6	1.6	0.9
Medication: Amlodipine	1.0	1.5	1.7	-1.1	-1.3
Exposure to tobacco smoke outside home	1.0	1.3	1.8	0.9	1.3
Neck or shoulder pain in last month	1.0	1.4	2.1	0.9	1.4
Bipolar Disorder or Schizophrenia	0.9	2.1	2.5	-1.4	-1.6
Rheumatoid Arthritis	0.9	1.3	2.4	-0.3	-1.6
Triglycerides	0.9	1.5	1.7	1.1	1.3
Respiratory disease	0.9	2.1	2.4	-1.3	-1.6
Hearing difficulty/problems: Yes	0.9	1.4	2.5	-0.5	-1.6
Ever had hysterectomy (womb removed)	0.9	1.0	1.3	1.2	0.8
Alcohol usually taken with meals	0.9	1.5	1.9	-1.4	-1.1
Nervous feelings	0.9	1.6	2.1	-1.1	-1.5
Medication: Cholesterol lowering	0.9	1.4	1.4	-1.2	-1.2
Wheeze or whistling in the chest in last year	0.9	1.7	2.2	1.5	1.0
Comparative height size at age 10	0.9	4.7	7.6	-2.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.1	0.8	1.4
Illnesses of father: None of the above (group 1)	0.9	1.1	1.4	1.2	0.9
Medication: Bendroflumethiazide	0.9	1.4	1.9	-1.4	-1.0
Depression (Nagel 2018)	0.8	1.2	2.1	1.5	0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	1.9	-0.7	-1.4
Mean Putamen Volume	0.8	0.9	1.7	1.3	0.4
Happiness	0.8	0.9	1.1	-1.0	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.4	0.6	1.2
Qualifications: College or University degree	0.8	2.6	2.9	-1.7	-1.6
Eye problems/disorders: None of the above	0.8	0.9	1.5	1.2	0.6
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.1	1.0	0.9
Back pain experienced in last month	0.8	1.1	1.2	1.0	1.1
Mother’s age at death	0.8	1.0	1.7	-0.4	-1.3
Medication: Atorvastatin	0.8	0.9	1.1	-0.9	-1.0
Number of operations (self-reported)	0.8	1.2	1.3	-1.1	-1.2
Chronotype (morning person)	0.7	1.7	2.3	1.0	1.5
Loud music exposure frequency	0.7	0.8	1.3	0.6	1.1
Health satisfaction	0.7	0.9	1.5	0.6	1.2
Heart disease (mother)	0.7	0.9	1.6	0.4	1.3
Asthma (self-reported)	0.7	1.4	1.6	-1.3	-1.1
Ever taken oral contraceptive pill	0.7	0.8	1.2	-1.1	-0.6
Commuting to job workplace: Public transport	0.7	0.8	1.5	-1.2	-0.3
Risk taking	0.7	1.0	1.0	1.0	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	-0.4	-1.2
Bipolar Disorder (2018)	0.6	1.0	1.1	-0.9	-1.1
Schizophrenia (2018)	0.6	1.2	1.3	-1.0	-1.2
Cardiovascular Disease	0.6	2.0	3.5	-1.9	-0.7
Medication for hormone replacement therapy	0.6	0.7	1.1	-1.1	-0.5
Taking other prescription medications	0.6	1.0	1.5	1.2	0.7
Serious illness, injury or assault to yourself	0.6	0.8	1.4	0.4	1.2
Hair/balding pattern: Pattern 3	0.6	0.9	1.3	1.2	0.7
Breastfed as a baby	0.6	0.8	1.2	0.6	1.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.0	1.0	0.7
Migraine (self-reported)	0.6	0.8	1.4	-1.2	-0.4
Hypertension (Self-reported)	0.6	1.7	2.9	-1.7	-0.7
Diabetes diagnosed by doctor	0.6	1.0	1.8	-0.5	-1.3
Eye problems/disorders: Glaucoma	0.6	0.7	0.9	1.0	0.7
Medication: Paracetamol	0.6	0.9	1.0	-1.0	-0.9
Lupus	0.5	0.8	1.1	1.1	0.7
Schizophrenia (2014)	0.5	1.0	1.1	-1.0	-1.0
Blood Platelet Count	0.5	5.5	5.7	-2.3	-2.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.0	-0.5	-1.0
Relative age voice broke	0.5	0.8	1.4	-0.4	-1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.7	0.7	0.9
High blood pressure	0.5	1.5	2.7	-1.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.3	-1.1
Fluid intelligence score	0.5	1.0	1.9	-0.1	-1.4
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.2	1.1
Medication for cholesterol	0.5	0.7	1.0	0.7	1.0
Osteoarthritis (self-reported)	0.5	0.6	1.1	-1.1	-0.2
Number of self-reported non-cancer illnesses	0.5	0.9	1.2	-1.1	-0.8
Illnesses of father: High blood pressure	0.5	0.7	0.8	-0.7	-0.9
Myopia	0.5	0.8	1.3	1.1	0.6
Pain experienced in last month	0.5	0.9	1.4	-0.6	-1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.9	0.6	0.9
Worry (Nagel 2018)	0.4	0.9	1.0	-1.0	-0.9
Sitting height	0.4	3.1	5.1	-2.3	-1.0
Heart attack	0.4	0.4	0.5	0.7	0.6
Blood clot in the leg (DVT)	0.4	0.5	1.0	-0.1	1.0
Medication: Paracetamol	0.4	0.6	0.8	-0.7	-0.9
Leg fat percentage (right)	0.4	1.5	2.2	0.9	1.5
Medication: Omeprazole	0.4	0.5	0.9	0.1	-0.9
Smoking status: Previous	0.4	0.6	0.6	-0.8	-0.8
Average weekly red wine intake	0.4	0.6	0.7	-0.7	-0.8
Smoking status: Current	0.4	0.6	0.9	1.0	0.5
Cholesterol lowering medication	0.4	0.6	1.1	-0.2	-1.0
Irritable Bowel Disease (IBD)	0.3	0.8	1.1	-0.6	-1.1
Ulcerative Colitis (UC)	0.3	0.5	0.6	-0.6	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	-0.1	-1.1
Ovarian Cancer	0.3	0.3	0.6	-0.4	-0.7
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.3	-0.8
Systolic Blood Pressure	0.3	1.4	1.7	-1.0	-1.3
Neuroticism	0.3	0.8	0.8	-0.9	-0.9
Hair Pigment	0.3	7.5	9.1	2.4	3.0
Number of treatments/medications taken	0.3	0.5	0.5	-0.7	-0.7
Trunk fat percentage	0.3	1.2	2.2	0.5	1.5
Maternal smoking around birth	0.3	0.5	0.9	-1.0	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	0.6	-0.8	0.4
Supplements: Glucosamine	0.3	0.4	0.7	-0.8	-0.2
Hearing difficulty/problems with background noise	0.3	0.4	0.8	-0.2	-0.9
Neuroticism score	0.3	0.6	0.7	-0.8	-0.7
Father’s age at death	0.3	0.3	0.4	0.6	-0.5
Falls in the last year	0.3	0.4	0.5	0.7	0.4
Pulse rate	0.3	0.5	0.7	-0.5	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.7	-0.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.4	0.7	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.8	-0.3
Length of working week for main job	0.3	0.3	0.7	-0.8	-0.1
Body fat percentage	0.3	1.2	2.1	0.5	1.5
Leg fat mass (right)	0.3	1.3	2.4	0.5	1.6
Suffer from ‘nerves’	0.3	0.5	0.5	-0.7	-0.7
Age at last live birth	0.3	0.5	0.8	0.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.0	-0.3	1.0
Arm fat percentage (left)	0.3	1.0	2.0	0.3	1.4
Wears glasses or contact lenses	0.3	0.3	0.6	-0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.8	-0.4
Medication: Lisinopril	0.3	0.4	0.7	0.8	0.3
Ever smoked	0.3	0.5	0.7	-0.6	-0.8
Leg fat percentage (left)	0.3	1.0	1.7	0.4	1.3
Fractured/broken bones in last 5 years	0.3	0.3	0.5	-0.7	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	1.3	0.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.8	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	-0.5	0.7
Heart disease (siblings)	0.3	0.3	0.7	0.1	0.8
Alcohol drinker status: Previous	0.3	0.4	0.6	-0.8	-0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.2	-0.7
LDL Cholesterol	0.2	0.3	0.4	0.7	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.5	-0.4
Ulcerative Colitis	0.2	0.3	0.6	0.8	-0.2
BMI	0.2	0.9	1.6	-1.3	-0.3
Waist Hip Ratio (WHR)	0.2	0.9	1.8	-1.3	-0.3
Lung FVC	0.2	0.9	1.2	1.1	-0.8
Sensitivity / hurt feelings	0.2	0.4	0.6	0.4	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	0.6	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	0.4	0.5
Current tobacco smoking	0.2	0.3	0.6	0.8	-0.0
High blood pressure (mother)	0.2	0.3	0.3	0.5	0.5
Body mass index (BMI)	0.2	1.0	1.9	0.4	1.4
Trunk fat mass	0.2	0.9	1.8	-0.1	1.3
Waist circumference	0.2	0.8	1.4	0.4	1.2
Past tobacco smoking	0.2	0.3	0.4	0.5	0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	-0.4	-0.5
Weight	0.2	1.0	1.8	-0.3	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.4	0.7	0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.6	0.4
Headache pain in last month	0.2	0.3	0.6	0.2	0.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.2	-0.6
Comparative body size at age 10	0.2	0.6	1.0	-0.3	-1.0
Medication: Ibuprofen	0.2	0.2	0.5	-0.7	-0.1
Whole body fat mass	0.2	1.0	1.9	0.0	1.4
Number of full sisters	0.2	0.2	0.2	0.4	0.5
Chest pain or discomfort	0.2	0.3	0.4	-0.5	0.6
Medication: Aspirin	0.2	0.3	0.5	0.7	0.3
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.1	0.7
Leg fat-free mass (right)	0.2	0.9	1.5	-1.2	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.2	0.6
Loneliness, isolation	0.2	0.3	0.5	0.2	-0.7
Mineral and other dietary supplements	0.2	0.2	0.3	0.5	0.4
Leg predicted mass (right)	0.2	0.8	1.4	-1.2	0.5
Arm fat mass (left)	0.2	0.7	1.5	-0.1	1.2
Diastolic blood pressure, automated reading	0.2	0.7	0.8	-0.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	0.4	-0.5
Supplements: Calcium	0.2	0.2	0.3	0.2	0.6
Leg fat mass (left)	0.2	0.9	1.7	0.1	1.3
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.6	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.3	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.4	-0.2
Crohns Disease (2017)	0.1	0.2	0.4	-0.2	-0.6
Reaction Time	0.1	0.3	0.3	-0.6	0.5
Prostate Cancer	0.1	0.1	0.3	0.5	-0.1
Fasting Glucose	0.1	0.1	0.1	-0.3	0.2
HDL Cholesterol	0.1	0.1	0.2	-0.5	-0.2
Blood Red Count	0.1	1.1	1.1	-1.1	-1.0
Heel T-Score	0.1	0.9	1.0	-0.9	-1.0
Smoking Status	0.1	0.2	0.2	-0.5	-0.3
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.9	-0.2
Hand grip strength (left)	0.1	0.2	0.2	0.3	0.5
Average weekly spirits intake	0.1	0.1	0.1	-0.3	0.2
Relative age of first facial hair	0.1	0.2	0.4	0.7	-0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	-0.3
Vitamin and mineral supplements	0.1	0.1	0.1	0.3	-0.3
Impedance of leg (right)	0.1	0.7	1.3	1.1	0.2
Leg fat-free mass (left)	0.1	0.7	0.8	-0.9	0.7
Hand grip strength (right)	0.1	0.3	0.5	0.4	0.7
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.5	0.1
Fed-up feelings	0.1	0.2	0.3	0.5	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	0.6	0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.4	0.2
Impedance of leg (left)	0.1	0.3	0.6	0.8	0.0
Leg predicted mass (left)	0.1	0.7	0.9	-1.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	0.2	-0.3
Medication: Ramipril	0.1	0.2	0.2	-0.4	0.4
Arm fat percentage (right)	0.1	0.5	1.0	-0.2	1.0
Trunk fat-free mass	0.1	0.6	1.1	-1.1	0.1
Hip circumference	0.1	0.4	0.8	0.1	0.9
Prospective memory result	0.1	0.2	0.2	0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.5	0.5	0.7
Arm fat mass (right)	0.1	0.6	1.1	-0.4	1.0
Trunk predicted mass	0.1	0.5	0.9	-1.0	0.2
Standing height	0.1	1.2	2.4	-1.6	0.0
Exposure to tobacco smoke at home	0.1	0.2	0.2	0.4	0.4
Tense / ‘highly strung’	0.1	0.1	0.1	-0.3	-0.4
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.7	-0.2
Pulse wave reflection index	0.1	0.1	0.2	0.4	0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.2	0.4
Birth weight	0.1	0.3	0.4	-0.6	0.5
Arm fat-free mass (right)	0.1	0.3	0.6	-0.8	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.1	0.6
Medication: Blood pressure	0.1	0.1	0.2	-0.4	0.1
Medication: Seretide 50 evohaler	0.1	0.2	0.3	-0.5	-0.1
Mean time to correctly identify matches	0.1	0.1	0.2	-0.3	0.4
Arm predicted mass (right)	0.1	0.3	0.3	-0.6	0.4
Alcohol intake frequency.	0.1	0.2	0.4	0.6	-0.2
Whole body fat-free mass	0.1	0.6	1.0	-1.0	0.4
Mood swings	0.1	0.2	0.4	-0.7	-0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.3	-0.4
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	-0.2
Eye problems/disorders: Cataract	0.1	0.2	0.3	-0.1	0.6
Medication: Aspirin	0.1	0.2	0.3	0.6	0.0
Medication: Gliclazide	0.1	0.1	0.1	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.7	0.3
Whole body water mass	0.1	0.7	1.3	-1.1	0.2
Hearing aid user	0.1	0.1	0.2	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.3	0.3
Basal metabolic rate	0.1	0.6	1.0	-1.0	0.5
Arm fat-free mass (left)	0.1	0.4	0.8	-0.9	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.3	-0.4
Arm predicted mass (left)	0.1	0.5	1.0	-1.0	0.0
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.2	-0.3
Breast Cancer	0.0	0.0	0.1	-0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	0.2	0.1
Crohns Disease (2012)	0.0	0.0	0.0	0.0	-0.2
HbA1C	0.0	0.1	0.1	-0.3	-0.2
Neuroticism (2016)	0.0	0.1	0.1	-0.3	0.3
Height	0.0	0.8	1.6	-1.3	-0.1
Allergy or Eczema	0.0	0.1	0.1	0.3	-0.1
Tanning	0.0	0.2	0.3	0.1	-0.5
Supplements: Zinc	0.0	0.0	0.0	0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.3	-0.1
Multivitamins +/- minerals	0.0	0.1	0.1	-0.3	0.2
Medication: Atenolol	0.0	0.1	0.1	-0.3	-0.2
Number of incorrect matches in round	0.0	0.1	0.1	-0.4	-0.1
Had menopause	0.0	0.0	0.0	0.1	0.2
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	0.0	0.1
Allergy	0.0	0.0	0.0	0.0	-0.2
Pain all over the body in last month	0.0	0.0	0.1	-0.2	0.2
Impedance of arm (right)	0.0	0.0	0.1	-0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	-0.2	-0.1
Lung cancer (father)	0.0	0.1	0.1	0.1	-0.3
Impedance of arm (left)	0.0	0.2	0.3	0.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.2	0.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.2	-0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.1	-0.0
Gout (self-reported)	0.0	0.0	0.1	-0.2	0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.3	0.3
Worry too long after embarrassment	0.0	0.1	0.1	-0.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.2	0.1
Age at first live birth	0.0	0.1	0.1	-0.4	0.0
Medication: Allopurinol	0.0	0.0	0.0	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.1	0.3
Overall health rating	0.0	0.1	0.1	-0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	-0.2	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.0	-0.1	-0.2
Miserableness	0.0	0.1	0.1	-0.3	-0.1
Guilty feelings	0.0	0.0	0.0	0.0	-0.1
Financial situation satisfaction	0.0	0.1	0.1	-0.2	0.3
Medication: Blood pressure	0.0	0.0	0.0	0.1	-0.0
Alcohol drinker status: Never	0.0	0.0	0.1	0.0	-0.3
Irritability	0.0	0.0	0.1	-0.3	-0.1
Age started oral contraceptive pill	0.0	0.0	0.1	-0.2	-0.1
Impedance of whole body	0.0	0.0	0.1	0.3	-0.0

Hub : Genes

CYP8B1

Models

Trait associations