Hub : Genes

ACKR2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.0938 0.0370 4.0e-03 0.011 NA 0.014 NA 0.027 4.5e-02 NA 2.9e-02 NA 3.7e-03
2 METSIM Adipose 0.0481 0.0197 4.0e-04 0.023 0.030 0.041 0.032 0.033 2.1e-04 2e-05 6.7e-07 1.1e-05 7.9e-06
3 ROSMAP Brain Pre-frontal Cortex 0.2084 0.0404 2.6e-14 0.128 0.141 0.131 0.144 0.146 3.5e-16 1e-17 1.7e-16 4.9e-18 2.6e-18

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.5 3.9 -0.7 -0.2 2.0
Bipolar Disorder or Schizophrenia 0.5 1.1 3.2 -0.3 -0.4 1.8
Depressed Affect (Nagel 2018) 1.1 2.4 4.1 2.0 1.7 -0.3
Depression (Nagel 2018) 2.8 4.2 7.4 1.7 1.5 -2.7
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.1 0.4 -0.1 0.2
Neuroticism (Nagel 2018) 0.7 1.6 3.0 1.7 1.4 -0.3
Schizophrenia (2018) 0.1 0.2 0.5 0.2 -0.3 0.7
Schizophrenia vs Biploar Disorder 0.3 0.4 0.9 -0.4 -1.0 -0.4
Worry (Nagel 2018) 0.0 0.1 0.2 0.3 -0.4 -0.1
Alzheimer’s Disease (in mother) 0.1 0.2 0.3 -0.6 -0.3 0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.0 0.4 0.7
Alzheimer’s Disease (including proxy) 0.2 0.3 0.5 -0.7 0.4 0.6
Crohns Disease (2017) 0.8 1.7 4.6 2.1 -0.8 -0.0
Irritable Bowel Disease (IBD) 0.5 1.3 2.6 1.1 -1.6 0.1
Ulcerative Colitis (UC) 0.6 1.1 3.1 -0.5 -1.8 -0.1
Major Depression (MDD) 1.2 1.4 2.2 0.0 -1.5 1.5
Reaction Time 1.2 2.3 4.1 1.6 -2.0 0.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.6 -0.2 -0.8 0.5
Breast Cancer 0.4 0.9 2.1 -1.4 -0.0 0.8
Ovarian Cancer 0.6 0.8 2.2 1.5 -0.2 0.3
Prostate Cancer 1.5 2.1 6.0 2.5 0.5 0.1
Age at First Birth 1.4 2.1 3.3 -1.3 -1.8 1.1
Bipolar Disorder (2011) 1.7 1.7 4.1 -0.6 -0.7 2.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.0 -0.5 1.4 0.4
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.1 0.1 0.0
Crohns Disease (2012) 1.3 2.1 6.1 2.5 -0.2 0.1
Mean Putamen Volume 1.5 1.7 4.7 -0.7 2.2 -0.1
Fasting Glucose 1.6 1.9 3.6 0.9 1.1 -1.9
HbA1C 1.5 1.7 2.4 1.5 0.9 -1.4
HDL Cholesterol 0.1 0.1 0.2 0.4 0.1 -0.4
LDL Cholesterol 1.2 2.0 5.9 0.1 2.4 0.1
Lupus 0.1 0.2 0.3 -0.3 0.6 -0.5
Neuroticism (2016) 0.4 0.5 1.5 1.2 -0.4 -0.1
Primary Biliary Cirrhosis 1.7 2.4 6.9 -2.6 -0.7 -0.1
Rheumatoid Arthritis 0.7 0.9 1.5 -1.2 -1.0 -0.4
Schizophrenia (2014) 0.5 1.0 1.7 1.1 0.4 1.3
Triglycerides 1.0 1.7 2.7 -0.5 1.6 -1.5
Type 2 Diabetes (T2D) (2012) 1.3 1.5 4.3 -2.1 -0.5 0.0
Ulcerative Colitis 0.0 0.1 0.1 -0.1 -0.4 -0.3
Blood Eosinophil Count 5.2 40.3 78.2 3.4 5.6 -8.8
Blood Platelet Count 0.1 0.7 1.1 1.0 -0.5 0.8
Blood Red Count 0.2 1.8 4.3 1.0 2.1 0.2
Blood White Count 5.9 43.5 73.3 2.7 7.1 -8.6
Heel T-Score 0.0 0.2 0.4 0.2 0.6 0.5
BMI 0.4 2.0 5.3 2.3 0.1 0.9
Height 0.2 4.6 13.0 -0.5 -3.6 -0.8
Waist Hip Ratio (WHR) 0.7 3.1 5.3 1.9 -0.6 -2.3
Systolic Blood Pressure 0.0 0.2 0.3 0.3 -0.4 -0.6
Smoking Status 0.1 0.3 0.8 0.9 0.4 -0.1
Allergy or Eczema 0.0 0.1 0.3 -0.5 -0.2 -0.1
Cardiovascular Disease 0.2 0.7 1.0 1.0 1.0 0.1
Hypothyroidism (self reported) 0.5 1.1 2.7 -0.4 -0.7 1.6
Respiratory disease 0.5 1.1 2.5 -0.8 -0.2 1.6
Type 2 Diabetes (T2D) (2018) 0.7 1.4 2.9 1.7 -0.9 0.6
Lung FEV1/FVC ratio 0.5 2.8 4.4 -0.6 -2.1 1.9
Lung FVC 0.0 0.1 0.1 0.4 -0.3 0.0
Neuroticism 0.9 2.3 4.6 2.1 0.6 -1.4
Chronotype (morning person) 0.2 0.4 0.9 0.5 0.2 -0.9
Hair Pigment 0.1 1.7 5.0 -2.2 -0.0 -0.1
Tanning 0.0 0.4 1.1 -0.2 0.3 -1.0
Hand grip strength (left) 0.0 0.1 0.2 0.3 0.3 -0.5
Number of treatments/medications taken 0.3 0.5 1.1 0.7 1.0 0.0
Average weekly spirits intake 0.6 0.7 2.1 1.4 0.4 -0.1
Sensitivity / hurt feelings 0.7 1.2 2.2 1.5 1.2 -0.0
Frequency of depressed mood in last 2 weeks 1.8 2.6 4.6 1.5 0.9 -2.1
Hearing difficulty/problems: Yes 0.9 1.3 2.3 1.5 0.3 1.3
Relative age of first facial hair 0.5 1.0 1.5 1.2 1.1 -0.6
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 3.1 1.8 0.2 -1.1
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 0.5 -0.1 0.1
Ever had hysterectomy (womb removed) 0.9 1.1 1.6 1.2 1.2 -0.2
Systolic blood pressure, automated reading 0.6 1.6 4.1 0.4 -2.0 0.7
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 2.3 1.4 -0.3 -1.5
Angina 1.1 1.4 3.2 0.6 1.8 -0.8
Medication for hormone replacement therapy 0.5 0.6 1.0 0.9 -0.0 1.0
Vitamin and mineral supplements 0.1 0.1 0.3 -0.5 -0.3 -0.2
Supplements: Zinc 0.7 0.8 1.4 1.2 0.0 1.0
Medication: Co-codamol 0.8 1.0 2.9 -0.1 1.7 0.2
Medication: Metformin 1.7 2.4 3.4 1.6 -1.9 1.1
Diabetes (father) 1.2 1.5 2.2 -1.5 -0.8 1.3
Diabetes (mother) 1.2 1.6 4.2 0.7 -0.3 2.0
Severe depression (siblings) 0.0 0.0 0.0 -0.1 0.2 0.1
Pack years adult smoking proportion 1.9 2.9 6.8 -0.3 1.4 -2.6
Impedance of leg (right) 1.3 6.4 16.2 -4.0 -1.7 0.3
Leg fat-free mass (left) 0.3 1.7 4.9 2.2 0.3 -0.2
Trunk fat percentage 0.3 1.2 2.5 -1.6 -1.1 -0.3
Hand grip strength (right) 0.2 0.6 1.0 0.8 1.0 -0.4
Townsend deprivation index at recruitment 0.6 0.9 1.8 0.0 1.3 -0.9
Current tobacco smoking 0.5 0.8 1.6 -0.4 -0.7 -1.2
Average weekly fortified wine intake 0.2 0.2 0.4 -0.3 0.6 -0.3
Maternal smoking around birth 1.6 2.3 5.6 -0.9 -2.4 0.7
Fed-up feelings 0.6 1.2 1.9 1.4 1.3 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.6 4.5 0.2 1.8 -2.1
Relative age voice broke 0.2 0.4 0.8 0.5 0.3 0.9
Taking other prescription medications 0.7 1.0 2.1 -0.0 1.5 -1.0
Age when periods started (menarche) 0.1 0.3 0.8 0.0 0.9 -0.3
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 1.6 -0.2 1.3 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.3 -0.1 1.5 0.3
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 3.4 1.8 1.3 -0.7
Qualifications: CSEs or equivalent 0.9 1.2 3.2 0.2 -1.8 0.7
Serious illness, injury or assault to yourself 0.7 0.9 1.5 0.5 0.9 -1.2
High blood pressure 0.1 0.3 0.7 0.8 0.1 0.3
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 -0.2 -0.3 0.4
Multivitamins +/- minerals 0.0 0.0 0.0 0.1 0.0 -0.2
Stomach or abdominal pain in last month 2.5 3.1 7.7 0.3 1.2 -2.8
Supplements: Glucosamine 0.9 1.2 2.9 -1.7 -0.5 0.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 0.2 -1.0 -0.6
Medication: Atenolol 0.3 0.4 0.9 0.4 0.9 -0.3
Medication: Levothyroxine sodium 0.8 1.4 3.1 -0.9 0.5 1.8
Sitting height 0.3 2.3 4.3 -0.7 -2.1 1.5
Chronic bronchitis/emphysema (father) 0.5 0.6 1.7 1.3 -0.4 -0.2
High blood pressure (mother) 0.4 0.5 1.1 -0.2 -1.1 -0.6
Body mass index (BMI) 0.5 2.1 3.1 1.8 1.7 -0.5
Impedance of leg (left) 1.2 5.6 12.9 -3.6 -2.0 0.2
Leg predicted mass (left) 0.3 1.7 4.9 2.2 0.2 -0.2
Trunk fat mass 0.1 0.5 0.9 -0.8 -0.9 -0.2
Waist circumference 0.4 1.3 1.9 1.4 0.9 -1.1
Number of incorrect matches in round 0.3 0.6 1.5 -1.2 -0.1 0.4
Past tobacco smoking 1.5 2.7 3.7 -1.7 -1.2 -1.9
Alcohol usually taken with meals 2.3 3.7 6.2 -2.5 -1.7 1.4
Nervous feelings 0.1 0.1 0.2 0.3 -0.3 0.4
Frequency of tenseness / restlessness in last 2 weeks 1.9 3.0 4.9 1.6 2.2 -1.2
Hearing difficulty/problems with background noise 0.3 0.4 1.0 0.3 0.5 1.0
Hair/balding pattern: Pattern 2 4.3 5.4 8.4 0.4 -2.8 2.9
Had menopause 0.4 0.5 0.9 -1.0 0.6 -0.5
Had other major operations 2.4 2.9 4.8 2.2 1.4 -1.3
Forced vital capacity (FVC) 0.3 1.1 1.3 -1.1 -1.1 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.7 -0.1 1.3 0.8
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 0.6 -0.8 -0.8 -0.3
Qualifications: None of the above 0.7 1.6 3.4 0.7 1.9 -0.8
Financial difficulties in last 2 years 3.2 4.3 4.9 1.8 2.2 -2.1
Mouth/teeth dental problems 2.3 3.5 6.6 -1.5 -1.4 2.6
Heart attack 0.6 0.8 1.2 1.1 1.1 -0.0
Allergy 0.1 0.2 0.4 -0.1 -0.6 -0.6
Pain all over the body in last month 0.6 0.6 1.1 -0.7 0.4 1.1
Diabetes (self-reported) 1.3 2.0 3.1 1.8 -1.4 1.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 0.9 0.9 -0.8 -0.9
Medication: Ramipril 1.0 1.3 2.9 1.7 0.9 0.5
Medication: Simvastatin 1.3 1.9 5.4 2.3 0.2 0.6
Fluid intelligence score 0.5 1.1 1.7 -1.0 -1.3 -0.7
Illnesses of siblings 2.0 2.9 8.3 0.5 -0.1 -2.9
Neuroticism score 1.0 2.0 5.4 2.3 0.6 -0.5
Weight 0.1 0.7 1.6 1.3 0.5 -0.3
Impedance of arm (right) 2.4 11.3 21.4 -4.6 -3.5 0.6
Arm fat percentage (right) 0.0 0.2 0.3 -0.6 -0.5 -0.1
Trunk fat-free mass 0.5 3.0 7.8 2.8 1.1 -0.2
Hip circumference 0.0 0.1 0.4 0.6 0.1 -0.0
Time employed in main current job 2.0 2.3 6.7 -0.4 -2.6 0.5
Alcohol intake versus 10 years previously 1.2 1.7 3.8 1.0 2.0 0.6
Father’s age at death 1.5 2.1 3.0 1.7 0.7 -1.7
Worrier / anxious feelings 0.4 0.8 1.7 1.3 -0.1 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.9 -0.4 0.9 0.1
Falls in the last year 0.2 0.3 0.4 0.6 0.6 0.2
Hair/balding pattern: Pattern 3 1.1 1.7 3.6 -1.9 1.0 -0.6
Number of live births 2.7 3.9 6.0 1.5 2.4 -1.9
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 2.3 -1.5 -1.5 1.5
Pulse rate 0.2 0.3 0.3 0.6 -0.3 -0.6
Happiness 0.7 0.8 1.5 -1.2 0.4 0.9
Noisy workplace 0.4 0.5 1.1 0.4 1.1 0.5
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 0.4 -0.3 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.1 0.2 0.4 -1.1
Mouth/teeth dental problems: Dentures 0.6 1.1 2.1 1.0 -0.4 -1.4
Asthma 0.5 1.0 2.6 0.7 0.1 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.0 -0.7 1.0 0.6
Medication: Cholesterol lowering 0.9 1.4 2.8 1.7 -0.1 1.2
Depression (self-reported) 1.7 2.0 3.4 -0.2 1.9 -1.6
Medication: Lansoprazole 1.0 1.1 2.7 0.5 1.7 -0.7
Prospective memory result 1.3 1.7 2.9 1.7 1.1 -0.8
Lung cancer (father) 0.1 0.1 0.2 0.4 0.4 -0.1
Illnesses of mother 0.6 0.8 0.9 0.7 0.9 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 1.0 -0.8 -1.0 0.8
Pulse wave Arterial Stiffness index 0.7 0.9 1.7 0.8 -0.5 1.3
Impedance of arm (left) 2.5 11.5 22.7 -4.8 -3.4 -0.0
Arm fat mass (right) 0.0 0.1 0.2 0.5 0.0 -0.0
Trunk predicted mass 0.5 3.1 7.6 2.8 1.2 -0.3
Standing height 0.3 2.5 6.7 -0.9 -2.6 0.2
Length of working week for main job 0.3 0.3 0.7 0.1 -0.9 0.4
Exposure to tobacco smoke at home 0.1 0.1 0.3 -0.0 0.1 -0.5
Breastfed as a baby 0.4 0.5 0.9 0.3 0.6 -0.9
Tense / ‘highly strung’ 0.1 0.1 0.4 0.2 0.6 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.9 0.4 -0.4 -1.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.5 0.7 0.0 -0.1
Birth weight of first child 1.2 2.3 4.4 1.5 -0.5 2.1
Peak expiratory flow (PEF) 0.8 1.8 3.6 -1.2 -0.6 1.9
Pulse wave reflection index 0.8 0.9 1.4 0.9 0.8 1.2
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.0 0.5 1.0 0.6
Loud music exposure frequency 0.5 0.5 1.5 0.0 1.2 0.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.8 -0.4 -1.4 1.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 0.6 1.1 -0.0
Blood clot in the leg (DVT) 0.7 0.9 1.5 1.0 1.2 -0.4
Medication: Paracetamol 0.5 0.8 2.5 0.0 0.1 1.6
Headache pain in last month 0.2 0.4 0.7 0.8 0.7 0.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.0 -1.0 -0.5 -1.0
Glaucoma (self-reported) 0.6 0.7 1.5 -0.5 1.2 -0.5
Gout (self-reported) 0.2 0.3 0.5 -0.3 -0.7 0.5
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.5 0.1 -0.4 1.6
Medication: Amlodipine 0.1 0.1 0.2 0.4 -0.2 -0.4
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 0.8 1.1 0.1
Birth weight 0.5 1.2 1.7 1.3 1.2 -0.6
Chronic bronchitis/emphysema (mother) 1.3 1.6 3.2 -1.1 -0.5 1.8
High blood pressure (siblings) 2.1 3.1 7.5 -1.3 0.0 2.7
Forced vital capacity (FVC), Best measure 0.2 0.8 1.2 -0.9 -1.1 0.7
Body fat percentage 0.2 0.6 1.5 -1.2 -0.6 -0.3
Leg fat percentage (right) 0.1 0.3 0.6 -0.4 0.8 -0.4
Arm fat-free mass (right) 0.7 3.5 8.4 2.9 1.4 -0.2
Exposure to tobacco smoke outside home 0.3 0.3 0.6 0.5 0.8 -0.3
Comparative body size at age 10 0.1 0.4 0.9 -0.5 0.3 0.9
Number of full brothers 0.2 0.3 0.6 0.8 -0.4 -0.2
Worry too long after embarrassment 0.1 0.2 0.3 0.5 -0.0 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.1 -0.2 -0.2
Wheeze or whistling in the chest in last year 0.5 0.9 2.3 0.1 1.5 -0.5
Number of children fathered 1.0 1.2 2.8 -0.4 0.8 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 3.9 2.0 0.8 -0.4
Age at first live birth 1.2 2.1 5.2 -2.3 -0.9 0.4
Pulse wave peak to peak time 0.8 0.9 1.9 -0.8 0.5 -1.4
Health satisfaction 1.0 1.3 2.3 1.0 1.5 -0.8
Shortness of breath walking on level ground 0.8 1.0 2.0 0.4 1.4 0.8
Qualifications: College or University degree 0.2 0.7 0.9 -0.8 -0.9 0.6
Eye problems/disorders: None of the above 0.9 1.1 1.5 -1.2 -0.9 0.9
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.8 0.4 1.7 -0.8
Emphysema/chronic bronchitis 0.5 0.5 0.9 -0.4 0.9 -0.8
Medication for pain relief, constipation, heartburn 0.4 0.6 1.5 -0.1 -1.2 -0.5
Neck or shoulder pain in last month 0.7 1.0 2.9 0.2 1.7 0.2
Medication: Blood pressure 0.2 0.4 0.7 0.3 0.9 0.6
Angina (self-reported) 1.1 1.5 3.5 0.3 1.9 -0.9
Migraine (self-reported) 0.3 0.4 0.8 0.5 0.3 0.9
Medication: Ibuprofen 0.1 0.2 0.5 -0.0 0.7 -0.0
Medication: Allopurinol 0.3 0.4 0.9 -0.0 -0.9 -0.6
Medication: Omeprazole 0.4 0.5 1.5 0.0 0.3 1.2
Medication: Seretide 50 evohaler 0.7 0.8 1.9 -1.4 -0.5 0.6
Mean time to correctly identify matches 0.8 1.6 3.5 1.1 -1.9 0.1
Heart disease (mother) 0.2 0.2 0.5 0.3 0.7 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.6 -0.5 1.0 1.6
Whole body fat mass 0.0 0.1 0.3 -0.3 -0.6 -0.3
Leg fat mass (right) 0.1 0.2 0.4 0.3 0.3 -0.6
Arm predicted mass (right) 0.6 3.3 7.7 2.8 1.4 -0.4
Pulse rate, automated reading 0.1 0.3 0.8 0.1 -0.4 0.9
Alcohol intake frequency. 0.4 0.9 2.1 0.6 1.5 -0.4
Comparative height size at age 10 0.8 4.4 7.6 1.1 -2.1 2.8
Number of full sisters 1.4 1.7 3.5 1.0 1.9 -0.9
Suffer from ‘nerves’ 0.2 0.4 0.7 -0.6 -0.9 -0.1
Overall health rating 0.9 1.9 4.2 0.9 2.0 -0.9
Chest pain or discomfort 0.7 1.0 2.0 -0.9 1.4 0.2
Had major operations 0.6 0.7 0.7 0.8 -0.8 0.8
Age at last live birth 0.3 0.5 0.9 -0.5 1.0 -0.6
Family relationship satisfaction 0.2 0.2 0.3 -0.3 0.6 0.5
Leg pain on walking 1.9 2.4 4.6 1.3 0.9 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.7 -1.3 0.6 -0.7
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.6 -0.8 -0.4 0.8
Illness, injury, bereavement, stress in last 2 years 3.4 4.1 7.6 -1.1 -1.9 2.8
Medication: Aspirin 0.4 0.6 0.7 0.6 0.8 -0.8
Supplements: Vitamin C 2.3 2.7 4.2 2.1 -0.8 1.8
Knee pain experienced in last month 2.8 4.3 10.3 0.6 3.2 -1.5
Hypertension (Self-reported) 0.2 0.6 1.0 1.0 0.4 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.9 -0.8 1.4 0.1
Illnesses of father: Heart disease 1.4 1.9 3.3 -0.4 1.5 1.8
Illnesses of siblings: Diabetes 0.3 0.3 0.6 0.4 0.5 0.8
Smoking status: Previous 0.9 1.4 1.9 1.2 0.9 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.7 -0.4 -0.8 0.0
Whole body fat-free mass 0.5 2.8 7.6 2.8 0.9 -0.2
Leg fat-free mass (right) 0.4 1.9 5.6 2.4 0.2 -0.1
Arm fat percentage (left) 0.1 0.2 0.3 -0.5 -0.3 -0.5
Average weekly red wine intake 0.1 0.2 0.5 -0.2 -0.2 0.7
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.0 -0.4 0.5
Mood swings 0.3 0.5 1.4 0.3 1.2 0.1
Loneliness, isolation 0.7 1.0 1.5 1.2 0.3 1.2
Long-standing illness, disability or infirmity 0.2 0.3 0.7 0.2 0.3 -0.8
Ever had bowel cancer screening 0.6 0.7 1.2 0.3 -0.8 -1.1
Diabetes diagnosed by doctor 0.7 1.1 2.7 1.6 -0.8 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.2 -0.5 1.1 -0.4
Friendships satisfaction 2.2 2.8 7.1 -0.8 0.8 2.7
Qualifications: nursing, teaching 2.4 3.7 6.9 -1.2 -1.6 2.6
Commuting to job workplace: Walk 2.2 2.4 5.9 2.4 1.0 0.6
Eye problems/disorders: Cataract 1.5 1.7 2.1 1.5 1.1 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.1 -0.6 0.2 -1.8
Medication for cholesterol 0.6 0.9 1.4 -1.2 -0.6 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.9 0.4 1.2 -1.7
Back pain experienced in last month 1.3 1.9 3.7 1.2 1.9 -0.8
Mineral and other dietary supplements 0.7 1.0 1.7 -1.3 -1.1 -0.2
Breast cancer (self-reported) 3.6 4.3 9.8 1.4 1.1 -3.1
Asthma (self-reported) 0.3 0.6 1.4 0.5 0.4 1.2
Osteoporosis (self-reported) 1.1 1.3 3.6 0.5 -0.4 1.9
Osteoarthritis (self-reported) 0.3 0.4 0.9 -0.4 -0.2 1.0
Medication: Aspirin 0.3 0.3 0.7 0.4 0.8 -0.5
Medication: Gliclazide 1.4 1.6 3.2 1.8 0.0 -1.3
Illnesses of father: None of the above (group 1) 1.8 2.2 5.5 1.0 -0.3 -2.3
Smoking status: Current 0.4 0.6 1.7 -0.3 -0.2 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.2 -0.5 -0.2 0.1
Whole body water mass 0.5 2.7 7.5 2.7 0.8 -0.0
Leg predicted mass (right) 0.4 2.0 5.9 2.4 0.1 -0.2
Arm fat mass (left) 0.0 0.1 0.2 0.3 0.1 -0.4
Number of self-reported non-cancer illnesses 2.0 3.4 8.5 2.9 1.1 -0.6
Average weekly champagne plus white wine intake 0.4 0.5 0.9 0.5 -1.0 -0.6
Miserableness 0.7 1.1 3.1 1.8 0.4 -0.4
Guilty feelings 0.7 1.0 1.8 1.4 1.0 -0.4
Wears glasses or contact lenses 0.5 0.6 1.7 1.3 0.4 0.1
Ever taken oral contraceptive pill 1.0 1.1 1.6 -1.3 -1.2 0.6
Hearing aid user 1.8 2.0 4.1 2.0 -1.4 0.2
Mother’s age at death 0.8 1.1 2.5 1.6 0.5 0.6
Financial situation satisfaction 0.5 0.6 1.0 1.0 0.9 0.4
Tinnitus: Yes, now most or all of the time 1.4 1.6 3.7 -1.9 0.9 -0.6
Commuting to job workplace: Public transport 0.0 0.0 0.1 -0.1 0.0 0.2
Eye problems/disorders: Glaucoma 0.8 1.0 2.2 0.4 0.7 -1.5
Medication: Blood pressure 1.6 3.1 3.9 2.0 1.3 -1.9
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.0 0.8 0.0 1.4
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.8 0.8 1.3 -0.5
High cholesterol (Self-reported) 0.8 1.5 2.4 1.5 0.4 1.4
Medication: Bendroflumethiazide 0.3 0.4 0.8 0.7 -0.0 0.9
Medication: Paracetamol 0.2 0.3 0.7 0.1 -0.6 0.9
Medication: Lisinopril 0.5 0.7 1.1 -0.8 1.1 -0.6
Medication: Atorvastatin 0.1 0.1 0.2 -0.1 0.4 0.5
Illnesses of father: High blood pressure 3.1 3.8 6.5 -2.1 0.7 2.5
Alcohol drinker status: Never 0.5 0.6 1.6 -1.2 -0.5 0.0
Ever smoked 0.7 1.3 2.5 1.0 0.6 1.6
Basal metabolic rate 0.4 2.0 5.3 2.3 0.7 -0.0
Leg fat percentage (left) 0.0 0.2 0.3 0.1 0.5 -0.5
Arm fat-free mass (left) 0.8 3.8 8.8 3.0 1.6 0.1
Number of operations (self-reported) 2.7 4.0 8.8 3.0 1.3 1.3
Average weekly beer plus cider intake 1.9 2.8 3.1 1.7 1.6 -1.8
Irritability 0.9 1.5 3.1 1.8 0.8 -0.8
Risk taking 0.3 0.5 0.6 -0.6 0.8 -0.6
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.5 0.6 -0.7 -0.2
Fractured/broken bones in last 5 years 0.7 0.9 2.4 0.5 -0.1 1.5
Age started oral contraceptive pill 0.1 0.1 0.4 0.0 0.2 0.6
Diastolic blood pressure, automated reading 0.1 0.3 0.4 -0.5 -0.6 0.6
Ever depressed for a whole week 0.3 0.3 0.8 -0.1 -0.9 -0.5
Unable to work because of sickness or disability 0.7 1.0 1.4 -0.9 1.2 -0.8
Commuting to job workplace: Cycle 0.2 0.2 0.5 -0.4 0.7 0.3
Myopia 1.0 1.4 4.1 -2.0 -0.3 -0.1
Vascular/heart problems diagnosed by doctor 0.2 0.7 1.9 -1.4 -0.3 0.1
Cholesterol lowering medication 0.6 0.9 1.4 1.2 0.8 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.4 0.1 0.2 1.2
Pain experienced in last month 0.5 0.9 1.2 -0.8 -1.1 0.9
Supplements: Calcium 1.4 1.5 3.6 0.1 0.9 1.9
Basal cell carcinoma (self-reported) 1.0 1.2 3.3 -0.1 0.4 1.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.1 0.8 1.0 0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.0 0.6 1.0 0.2
Heart disease (siblings) 0.1 0.1 0.3 -0.1 0.5 0.1
Alcohol drinker status: Previous 0.7 0.8 2.2 -0.4 -0.5 1.5
Pack years of smoking 1.8 2.6 6.0 -0.3 1.3 -2.5
Impedance of whole body 2.1 10.7 22.2 -4.7 -3.1 0.6
Leg fat mass (left) 0.0 0.1 0.3 0.4 0.1 -0.5
Arm predicted mass (left) 0.7 3.7 8.6 2.9 1.6 0.2