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chr3:49,598,064-51,398,958

Best TWAS P=6.52e-11 · Best GWAS P=1.93e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HYAL1	0.09	0.06	lasso	1	0.05	4.3e-05	6.1	6.1	1.2e-09	0.93	0.02	0.97	FALSE
2	GTEx	Adipose Visceral Omentum	CYB561D2	0.20	0.08	lasso	8	0.11	4.0e-06	5.5	-5.4	7.2e-08	-0.77	0.19	0.70	FALSE
3	GTEx	Brain Cortex	SEMA3B-AS1	0.67	-0.01	lasso	13	0.01	1.7e-01	6.4	5.2	1.6e-07	0.75	0.01	0.92	FALSE
4	GTEx	Cells Transformed fibroblasts	SEMA3B-AS1	0.15	0.01	enet	3	0.00	3.9e-01	5.8	6.3	2.3e-10	0.98	0.01	0.96	FALSE
5	GTEx	Esophagus Gastroesophageal Junction	HYAL1	0.30	0.13	lasso	9	0.10	2.1e-04	6.1	6.2	6.2e-10	0.95	0.01	0.98	FALSE
6	GTEx	Esophagus Mucosa	CYB561D2	0.07	0.02	lasso	4	0.02	3.1e-02	6.7	-6.1	9.2e-10	-0.93	0.02	0.95	FALSE
7	GTEx	Esophagus Muscularis	RASSF1	0.10	0.00	lasso	7	0.01	8.7e-02	5.6	5.8	7.0e-09	0.85	0.04	0.73	FALSE
8	GTEx	Esophagus Muscularis	HYAL1	0.11	0.08	lasso	5	0.05	3.3e-04	6.1	6.3	3.0e-10	0.96	0.01	0.98	FALSE
9	GTEx	Muscle Skeletal	HYAL1	0.08	0.08	lasso	3	0.06	7.6e-07	6.4	6.4	1.5e-10	0.96	0.01	0.99	FALSE
10	GTEx	Muscle Skeletal	CYB561D2	0.13	0.06	enet	14	0.07	1.4e-07	5.5	-5.4	6.7e-08	-0.83	0.06	0.93	FALSE
11	GTEx	Muscle Skeletal	SEMA3B-AS1	0.17	0.01	lasso	7	0.02	8.3e-03	6.7	5.9	3.7e-09	0.78	0.02	0.97	FALSE
12	GTEx	Nerve Tibial	RASSF1	0.05	0.03	enet	19	0.02	1.0e-02	5.8	5.3	9.3e-08	0.78	0.05	0.91	FALSE
13	GTEx	Nerve Tibial	U73166.2	0.07	0.03	lasso	3	0.03	2.8e-03	6.5	-6.5	6.5e-11	-0.95	0.01	0.97	TRUE
14	GTEx	Skin Not Sun Exposed Suprapubic	CYB561D2	0.08	0.01	enet	7	0.02	2.3e-02	5.5	-5.9	4.9e-09	-0.73	0.06	0.77	FALSE
15	GTEx	Skin Sun Exposed Lower leg	HYAL1	0.08	0.04	lasso	4	0.04	3.4e-04	6.4	-5.8	6.9e-09	-0.79	0.02	0.94	FALSE
16	GTEx	Skin Sun Exposed Lower leg	CYB561D2	0.13	0.02	lasso	3	0.05	5.7e-05	2.9	-5.5	3.2e-08	-0.75	0.02	0.98	FALSE
17	GTEx	Thyroid	CYB561D2	0.08	0.02	enet	9	0.03	2.3e-03	5.4	-5.6	2.4e-08	-0.82	0.03	0.95	FALSE
18	GTEx	Thyroid	U73166.2	0.05	0.02	enet	6	0.01	5.9e-02	6.3	-6.3	2.9e-10	-0.91	0.02	0.95	FALSE
19	GTEx	Uterus	RP11-804H8.6	0.55	0.00	lasso	3	-0.01	4.8e-01	6.1	5.6	2.2e-08	0.89	0.02	0.56	FALSE
20	METSIM	Adipose	CYB561D2	0.09	0.08	lasso	5	0.07	3.8e-10	6.1	-6.4	1.5e-10	-0.94	0.02	0.98	FALSE
21	METSIM	Adipose	HYAL1	0.07	0.04	enet	31	0.03	1.5e-05	6.1	6.0	2.0e-09	0.94	0.01	0.99	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	CACNA2D2	0.05	0.02	lasso	3	0.02	3.6e-03	6.4	-6.4	1.4e-10	-0.96	0.01	0.98	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	SEMA3B	0.05	0.03	lasso	6	0.02	8.3e-04	6.1	6.3	2.2e-10	0.97	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CYB561D2	0.10	0.02	lasso	3	0.01	1.9e-02	5.5	-5.4	8.7e-08	-0.73	0.00	0.17	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM115	0.06	0.04	lasso	3	0.05	9.7e-04	5.5	5.2	2.4e-07	0.75	0.03	0.46	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	HYAL1	0.10	0.06	lasso	3	0.05	1.2e-06	6.4	6.2	6.1e-10	0.95	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C3orf45	0.07	0.05	enet	4	0.05	2.9e-03	6.3	-6.0	2.2e-09	-0.88	0.00	0.92	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYB561D2	0.08	0.07	lasso	2	0.09	1.7e-09	5.5	-6.2	5.5e-10	-0.88	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CYB561D2	0.08	0.04	blup	17	0.08	9.3e-04	6.4	-5.8	7.3e-09	-0.79	0.01	0.75	FALSE