Hub : Genes

RAVER2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0710 0.0230 1.4e-04 0.063 0.034 0.058 0.041 0.060 3.8e-08 5.1e-05 1.3e-07 8.5e-06 8.6e-08
2 GTEx Brain Caudate basal ganglia 0.3460 0.0920 6.7e-04 -0.009 NA -0.010 NA -0.007 7.0e-01 NA 8.5e-01 NA 5.5e-01
3 GTEx Thyroid 0.1960 0.0520 3.7e-05 0.053 NA 0.027 NA 0.028 6.4e-05 NA 3.5e-03 NA 2.9e-03
4 METSIM Adipose 0.0329 0.0195 3.7e-02 -0.001 0.003 0.001 0.004 -0.001 6.3e-01 9.4e-02 2.1e-01 6.5e-02 5.8e-01
5 ROSMAP Brain Pre-frontal Cortex 0.3344 0.0403 0.0e+00 0.325 0.369 0.369 0.380 0.368 8.5e-43 8.6e-50 6.8e-50 1.0e-51 1.2e-49
6 TCGA Esophageal Carcinoma 0.1520 0.0750 3.4e-03 0.062 0.062 0.046 NA 0.069 5.0e-03 5.1e-03 1.4e-02 NA 3.3e-03
7 TCGA Brain Lower Grade Glioma 0.0441 0.0196 8.3e-06 0.025 0.053 0.045 NA 0.042 6.1e-04 1.0e-06 7.7e-06 NA 1.4e-05
8 TCGA Prostate Adenocarcinoma 0.0363 0.0201 1.8e-03 0.047 0.026 0.021 NA 0.038 9.7e-06 9.5e-04 2.3e-03 NA 6.4e-05
9 TCGA Thyroid Carcinoma 0.1150 0.0380 3.2e-12 0.079 0.133 0.140 NA 0.139 3.8e-08 6.2e-13 1.7e-13 NA 2.1e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.6 1.0 3.3 0.4 0.6 -0.9 0.7 0.4 1.3 1.8 1.2 -0.5
Bipolar Disorder or Schizophrenia 0.5 1.3 3.2 -1.6 1.8 -1.0 -1.6 -1.2 0.5 0.4 -0.5 -0.7
Depressed Affect (Nagel 2018) 0.3 0.7 2.0 0.2 1.4 -0.6 0.9 1.3 0.5 0.5 0.2 -0.6
Depression (Nagel 2018) 0.3 0.4 1.5 0.2 0.3 -1.2 0.1 0.4 1.1 0.5 0.0 -0.7
Intelligence (Savage-Jansen 2018) 2.6 8.0 16.7 3.5 -1.1 1.6 3.5 3.3 -0.4 3.2 4.1 2.2
Neuroticism (Nagel 2018) 0.6 1.4 3.4 1.0 0.5 -1.7 0.9 0.6 1.9 1.3 0.4 -1.2
Schizophrenia (2018) 1.2 2.5 6.6 -2.3 1.8 -0.5 -2.6 -1.8 -0.4 -0.9 -1.6 -0.5
Schizophrenia vs Biploar Disorder 1.6 2.1 4.9 -2.2 -1.0 0.1 -1.2 -2.0 -0.4 -2.0 -1.6 -1.1
Worry (Nagel 2018) 0.3 0.6 1.8 0.7 -0.1 -1.3 0.5 -0.4 1.2 0.5 -0.2 -0.9
Alzheimer’s Disease (in mother) 2.1 2.5 7.8 0.2 -0.2 -2.7 -0.1 -1.4 2.8 -0.2 -0.8 -2.1
Alzheimer’s Disease (in father) 0.6 0.7 1.7 0.7 -1.0 1.3 0.6 0.9 -0.5 0.3 1.1 0.3
Alzheimer’s Disease (including proxy) 0.8 1.2 4.2 0.8 -0.9 -1.4 0.2 -0.4 2.0 0.0 -0.0 -1.7
Crohns Disease (2017) 0.8 1.7 5.0 0.8 -0.1 2.2 0.8 0.2 -1.8 1.1 0.6 2.2
Irritable Bowel Disease (IBD) 1.4 3.3 10.2 -1.1 -0.5 3.2 -0.2 -1.7 -2.8 -0.2 -1.1 2.4
Ulcerative Colitis (UC) 1.9 3.5 7.4 -2.3 -0.1 2.7 -0.7 -2.2 -2.6 -1.0 -1.8 1.5
Major Depression (MDD) 1.3 1.6 4.1 1.3 0.9 -2.0 -0.1 0.5 2.0 1.4 0.7 -0.9
Reaction Time 0.4 0.7 4.2 -0.0 2.1 -0.5 -0.1 0.3 0.8 -0.5 -0.4 -0.7
Verbal and Numeric Reasoning (VNR) 1.8 4.2 9.2 2.4 -0.9 2.0 2.4 2.0 -0.7 2.0 3.0 1.8
Breast Cancer 1.4 3.5 8.1 1.6 -1.8 2.3 2.9 1.5 -0.8 1.2 1.9 2.0
Ovarian Cancer 0.2 0.3 1.1 0.3 -1.1 -0.6 0.5 0.0 0.8 0.3 -0.0 -0.5
Prostate Cancer 0.1 0.2 0.5 0.2 -0.4 0.1 0.0 0.4 -0.7 -0.2 -0.5 0.5
Age at First Birth 0.6 0.8 2.2 -1.5 0.6 0.2 -0.5 -0.6 -0.6 -1.5 -1.3 -0.1
Bipolar Disorder (2011) 0.3 0.3 1.0 0.8 0.3 -0.4 -0.4 0.2 0.5 1.0 0.8 0.1
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 -0.6 0.9 -0.2 0.2 0.2 0.2 -0.7 -0.3 -0.8
Coronary Artery Disease (CAD) 0.7 0.8 2.9 -0.5 1.7 -1.1 -0.5 0.2 0.8 1.1 -0.3 -0.8
Crohns Disease (2012) 1.2 1.9 6.1 0.2 -1.3 2.5 -0.4 -0.4 -2.1 -0.2 0.5 2.1
Mean Putamen Volume 1.2 1.4 3.9 -1.0 0.6 -2.0 -1.0 -0.4 1.4 0.0 -0.5 -2.0
Fasting Glucose 0.3 0.3 0.9 -0.2 0.1 -0.1 0.5 0.8 0.7 -1.0 0.1 -0.6
HbA1C 1.0 1.2 3.8 -0.4 1.1 1.9 -0.3 0.1 -1.8 -0.3 -0.1 1.3
HDL Cholesterol 0.4 0.6 2.2 0.0 -0.1 -1.4 -0.4 0.1 1.5 0.7 -0.1 -0.9
LDL Cholesterol 0.6 1.0 3.5 -1.0 -1.6 0.3 0.6 -1.9 -0.0 -0.9 -0.8 -0.2
Lupus 0.5 0.8 2.1 -1.4 0.3 0.0 -0.3 -1.1 -0.3 -1.2 -1.4 -0.2
Neuroticism (2016) 2.0 2.8 5.4 2.3 0.9 -1.9 0.3 1.9 2.0 2.2 1.7 -0.6
Primary Biliary Cirrhosis 0.4 0.6 2.0 -0.2 -0.9 -0.5 0.2 -0.7 0.9 -1.0 -0.3 -1.4
Rheumatoid Arthritis 1.0 1.4 7.1 1.4 -2.7 0.8 0.2 0.4 -0.4 0.9 1.0 0.7
Schizophrenia (2014) 1.7 3.7 9.0 -2.7 2.2 -1.0 -3.0 -1.9 0.2 -1.1 -2.0 -1.4
Triglycerides 0.2 0.3 0.8 -0.1 -0.8 0.7 0.5 -0.4 -0.9 -0.5 -0.4 0.4
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.7 0.4 0.3 -0.2 0.9 -0.0 0.5 0.5 0.9 0.1
Ulcerative Colitis 3.2 4.7 10.9 -2.1 -0.5 2.8 -1.6 -3.3 -2.6 -1.8 -2.0 1.7
Blood Eosinophil Count 1.6 12.5 41.9 -1.0 -6.5 -1.1 -1.7 -5.8 3.6 -2.0 -1.6 -3.5
Blood Platelet Count 1.2 14.3 41.9 4.2 1.6 -1.3 2.3 5.5 1.7 6.5 5.0 0.6
Blood Red Count 0.2 1.8 4.2 2.0 -0.6 -1.7 1.2 0.1 1.6 1.9 0.8 -0.1
Blood White Count 0.7 5.2 11.8 -3.1 3.4 -0.7 -3.2 -2.7 -0.4 0.0 -2.5 -0.7
Heel T-Score 0.9 7.4 21.2 1.0 -2.2 4.6 2.6 1.9 -3.4 0.6 2.1 3.7
BMI 0.6 3.4 6.1 2.1 2.2 0.6 2.4 2.5 -0.5 2.4 1.4 0.9
Height 0.1 1.6 4.4 0.4 -1.3 2.1 0.4 1.1 -2.0 -1.2 0.5 1.0
Waist Hip Ratio (WHR) 0.3 1.3 2.9 1.2 -0.4 0.8 0.8 1.7 -1.2 1.0 1.0 1.6
Systolic Blood Pressure 0.2 0.8 2.9 -0.5 0.8 -0.7 -1.7 -1.1 0.2 -0.4 -1.0 -0.9
Smoking Status 0.5 1.2 3.4 -1.5 0.6 -0.5 -1.8 -0.7 0.1 -0.9 -1.7 -0.9
Allergy or Eczema 1.2 3.2 9.4 0.0 -1.9 -3.0 -0.9 0.3 3.1 -0.1 -0.4 -2.4
Cardiovascular Disease 0.3 1.1 4.0 0.8 2.0 0.9 0.7 1.3 -0.9 0.4 0.7 0.8
Hypothyroidism (self reported) 2.7 6.2 23.7 2.6 -4.9 -1.8 1.4 -1.0 3.2 1.9 1.9 -1.2
Respiratory disease 1.3 2.9 9.8 0.4 -3.1 -2.0 -0.2 -1.1 2.5 -0.3 -0.6 -2.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 6.9 0.2 2.6 -0.0 -0.3 0.4 0.2 0.7 0.3 -0.3
Lung FEV1/FVC ratio 0.1 0.6 2.5 0.6 0.9 -0.7 -0.5 1.6 0.1 0.9 0.2 -0.0
Lung FVC 0.2 0.8 5.6 -0.0 0.1 -0.5 -2.4 -0.0 0.5 -0.4 -0.5 -0.6
Neuroticism 1.0 2.5 7.6 0.8 0.5 -2.8 0.4 -0.2 2.7 0.7 -0.3 -2.4
Chronotype (morning person) 1.3 3.0 7.2 0.7 -0.1 2.4 2.6 1.0 -2.0 0.8 1.2 2.7
Hair Pigment 0.1 2.5 6.9 0.2 1.8 1.7 2.3 2.6 -1.6 0.4 0.9 1.0
Tanning 0.1 1.1 3.5 0.6 0.1 -1.9 -1.0 -0.2 1.6 1.2 0.2 -0.8
Hand grip strength (left) 0.1 0.4 1.1 -0.1 -0.9 0.8 -1.1 0.4 -0.7 0.1 0.5 0.1
Number of treatments/medications taken 0.5 0.9 3.8 0.7 -0.2 0.0 2.0 1.0 0.7 0.9 1.1 0.4
Average weekly spirits intake 0.2 0.3 0.9 0.3 -0.4 -0.0 1.0 0.6 0.2 0.8 0.5 0.0
Sensitivity / hurt feelings 0.1 0.1 0.6 0.0 0.8 0.2 0.1 0.1 0.3 0.1 0.2 -0.5
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.0 0.9 -0.6 -1.7 0.3 0.0 1.6 0.7 0.0 -1.1
Hearing difficulty/problems: Yes 0.6 0.9 3.7 -0.5 0.3 -0.6 -1.9 -1.1 0.3 0.1 -1.3 -0.4
Relative age of first facial hair 0.1 0.2 0.7 0.5 -0.9 0.2 -0.1 0.0 0.3 -0.1 0.5 0.2
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 2.8 0.7 -0.6 0.3 1.7 1.6 0.6 -0.3 1.4 -0.0
Ever used hormone-replacement therapy (HRT) 0.8 1.1 2.4 1.3 -0.8 0.5 0.5 0.5 -0.3 1.5 1.3 1.5
Ever had hysterectomy (womb removed) 0.5 0.6 1.8 0.6 -1.3 -0.8 -1.3 -0.5 0.4 0.6 -0.3 -0.2
Systolic blood pressure, automated reading 0.2 0.6 1.4 0.3 0.7 -1.1 -1.2 -0.1 1.0 0.7 -0.2 -0.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 2.4 0.1 1.6 0.3 0.1 0.0 -0.2 0.6 0.2 0.3
Angina 0.3 0.4 1.7 0.1 1.2 0.6 0.5 0.0 -0.2 -1.3 -0.3 0.0
Medication for hormone replacement therapy 1.5 1.7 4.5 1.8 -1.2 -0.9 0.7 0.9 1.4 2.1 1.4 -0.1
Vitamin and mineral supplements 0.3 0.4 1.6 0.9 -0.1 0.2 1.2 0.6 0.4 0.0 0.7 0.0
Supplements: Zinc 1.4 1.5 2.6 0.5 -0.5 1.3 1.2 1.3 -1.0 1.3 1.6 1.6
Medication: Co-codamol 0.7 0.8 2.7 0.6 -1.6 0.5 0.9 1.0 0.1 1.1 1.0 0.2
Medication: Metformin 0.4 0.6 4.2 0.1 2.1 0.6 0.6 0.4 -0.4 0.3 0.2 0.3
Diabetes (father) 0.3 0.4 0.9 0.7 0.9 -0.7 -0.6 0.4 0.3 0.9 -0.2 -0.2
Diabetes (mother) 0.3 0.3 1.0 0.1 -0.1 -0.6 -0.1 -0.6 1.0 0.4 0.1 -1.0
Severe depression (siblings) 0.6 0.6 1.3 -1.1 0.4 -0.1 -1.0 -1.1 -0.3 -0.9 -1.1 0.3
Pack years adult smoking proportion 1.4 2.1 4.4 1.6 -1.3 0.3 2.0 2.1 -0.4 1.3 1.9 0.9
Impedance of leg (right) 0.9 4.6 9.7 -1.6 -0.6 -2.7 -3.1 -3.1 2.0 -0.6 -1.4 -2.3
Leg fat-free mass (left) 1.1 5.6 12.7 2.3 0.5 2.6 3.1 3.6 -2.2 1.4 2.1 2.1
Trunk fat percentage 0.2 0.9 3.7 0.8 1.9 -0.7 -0.2 -0.1 0.3 1.6 0.1 0.3
Hand grip strength (right) 0.1 0.3 1.5 -0.0 -1.2 0.5 -0.3 0.4 -0.1 -0.3 0.7 -0.1
Townsend deprivation index at recruitment 0.4 0.6 2.3 1.1 -1.5 -0.7 -0.6 0.1 0.6 0.7 0.2 -0.4
Current tobacco smoking 0.3 0.4 1.0 -0.9 0.4 1.0 -0.3 0.4 -0.9 -0.9 -0.4 0.3
Average weekly fortified wine intake 0.4 0.5 1.4 0.3 0.8 0.0 0.4 0.8 0.7 0.8 1.2 0.0
Maternal smoking around birth 0.7 1.0 2.4 0.9 1.5 -0.9 0.8 0.9 0.8 1.6 0.7 -0.1
Fed-up feelings 0.6 1.1 2.7 -1.0 -0.0 -1.4 -0.1 -0.7 1.3 -0.6 -1.4 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 0.3 -0.3 -1.0 -0.9 -0.2 0.6 0.9 -0.3 -0.5
Relative age voice broke 0.2 0.3 0.7 -0.8 0.3 -0.3 -0.1 -0.3 0.5 -0.5 -0.5 -0.8
Taking other prescription medications 0.8 1.2 2.1 1.5 -0.8 -0.5 1.4 0.9 1.4 1.1 1.3 -0.3
Age when periods started (menarche) 0.6 1.6 7.6 -0.2 -2.8 1.0 0.2 -1.9 -0.5 -1.2 -0.3 0.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 3.7 0.2 -1.9 -0.4 0.5 -0.1 0.9 -0.3 -0.3 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 6.3 2.4 -1.3 2.2 2.3 2.1 -1.6 1.6 2.5 2.5
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.3 -0.1 0.7 -1.5 -1.1 -1.0 1.0 1.3 0.1 -0.5
Qualifications: CSEs or equivalent 0.6 0.8 1.7 -0.9 -0.3 0.9 -0.2 -1.3 -0.9 -1.1 -1.1 0.4
Serious illness, injury or assault to yourself 1.0 1.3 3.9 1.1 -0.1 -1.8 -0.2 0.0 2.0 0.5 0.3 -1.7
High blood pressure 0.5 1.3 3.7 0.8 1.9 0.9 1.2 0.6 -1.1 1.1 0.9 1.4
Hayfever, allergic rhinitis or eczema 1.0 2.2 6.4 -0.3 -1.3 -2.5 -1.1 0.2 2.4 -0.3 -0.7 -2.1
Multivitamins +/- minerals 0.5 0.7 1.4 -0.7 0.0 1.0 -1.2 -1.1 -1.1 -0.2 -0.7 0.7
Stomach or abdominal pain in last month 0.3 0.4 2.3 0.5 -1.5 -0.1 0.1 0.7 -0.2 0.4 0.6 0.1
Supplements: Glucosamine 0.6 0.7 2.3 0.3 0.2 0.8 0.8 -0.4 -1.0 1.0 0.7 1.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.4 0.5 0.9 -1.6 -0.2 0.1 1.2 0.4 0.6 -0.8
Medication: Atenolol 1.9 2.4 6.2 2.1 -0.5 -0.2 2.0 1.2 1.1 2.0 2.5 -0.1
Medication: Levothyroxine sodium 1.6 2.7 8.8 1.1 -2.2 -2.1 0.2 -1.2 3.0 0.3 0.3 -1.8
Sitting height 0.4 2.5 7.1 0.2 0.7 2.7 1.1 1.6 -2.5 -0.6 0.9 1.9
Chronic bronchitis/emphysema (father) 1.0 1.2 3.4 0.9 -1.8 -0.9 1.3 -0.2 1.5 0.7 0.7 -1.0
High blood pressure (mother) 0.3 0.4 2.2 -0.2 0.9 0.1 1.5 0.4 0.4 0.2 0.5 -0.5
Body mass index (BMI) 0.5 1.9 5.0 1.6 1.5 0.2 1.8 1.8 0.1 2.2 1.1 0.6
Impedance of leg (left) 1.0 4.8 12.8 -1.8 0.1 -2.7 -3.6 -3.0 1.8 -0.6 -1.7 -2.1
Leg predicted mass (left) 1.1 5.8 12.8 2.4 0.5 2.6 3.1 3.6 -2.2 1.4 2.2 2.2
Trunk fat mass 0.3 1.3 3.8 1.3 2.0 0.2 0.7 1.0 -0.3 1.8 0.8 0.8
Waist circumference 0.9 3.2 6.6 1.9 1.7 1.0 2.1 2.6 -1.0 2.3 1.6 1.5
Number of incorrect matches in round 0.2 0.3 1.3 -0.5 0.3 0.4 -1.1 -0.2 -0.5 -0.3 -0.3 0.3
Past tobacco smoking 0.3 0.5 1.3 0.5 -0.1 0.3 1.1 1.1 -0.1 0.4 1.1 -0.3
Alcohol usually taken with meals 0.9 1.5 6.6 -2.1 0.1 1.1 0.3 -0.6 -0.5 -2.6 -0.8 -0.3
Nervous feelings 0.4 0.7 2.5 0.3 0.8 -1.6 0.2 0.2 1.3 0.5 -0.4 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.6 0.9 -0.1 -0.9 0.4 1.6 0.8 0.7 0.5 -0.6
Hearing difficulty/problems with background noise 0.3 0.4 1.0 -0.7 -0.4 0.9 -0.5 -0.5 -0.8 -0.6 -1.0 0.1
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 -0.2 -0.1 0.8 -0.7 0.3 -1.1 -0.2 -0.3 0.7
Had menopause 0.3 0.3 0.9 0.1 0.2 -1.0 -0.6 -0.8 0.9 -0.0 -0.1 -0.3
Had other major operations 0.8 1.0 2.5 1.2 1.0 0.5 0.9 1.6 -0.2 0.8 1.1 1.0
Forced vital capacity (FVC) 0.3 1.3 4.2 0.3 -0.2 1.7 -1.6 0.7 -2.0 -0.0 -0.0 1.2
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.4 9.9 3.1 -0.7 1.9 2.3 2.7 -1.7 2.0 2.8 2.8
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 4.5 -0.7 -0.8 2.1 0.7 -1.1 -1.6 -0.6 -0.1 1.0
Qualifications: None of the above 2.6 5.5 10.8 -2.5 1.8 -1.9 -3.3 -2.7 0.9 -1.6 -3.1 -2.3
Financial difficulties in last 2 years 1.8 2.4 5.4 2.3 -1.3 1.1 1.0 1.9 -0.9 1.3 1.7 1.7
Mouth/teeth dental problems 0.7 1.1 3.2 -0.6 0.2 1.7 0.4 0.5 -1.8 -1.2 0.2 1.2
Heart attack 5.5 7.0 19.0 1.3 -0.9 4.4 3.2 1.4 -3.6 0.1 1.7 3.7
Allergy 1.4 3.2 9.1 -0.7 3.0 2.6 0.7 0.0 -2.8 -0.2 0.3 2.0
Pain all over the body in last month 3.0 3.2 9.1 -2.4 1.1 -1.4 -2.4 -1.7 0.6 -0.9 -3.0 -1.1
Diabetes (self-reported) 1.0 1.6 7.1 -0.1 2.7 -1.4 -1.1 -0.4 1.4 0.7 -0.2 -1.1
Hayfever/allergic rhinitis (self-reported) 2.0 2.6 8.2 1.2 -0.8 -2.9 -1.3 0.6 2.7 0.5 0.1 -2.0
Medication: Ramipril 1.2 1.6 3.4 0.8 0.9 1.9 0.8 1.2 -1.8 0.6 0.8 1.8
Medication: Simvastatin 0.4 0.6 1.4 0.5 1.2 -0.6 -0.1 0.7 1.0 1.0 0.9 -0.3
Fluid intelligence score 2.3 4.8 9.0 2.6 -1.2 1.7 2.9 1.8 -0.5 2.4 3.0 2.2
Illnesses of siblings 0.9 1.2 4.6 0.6 -2.1 0.8 1.7 1.0 0.3 0.2 1.2 0.1
Neuroticism score 0.6 1.3 3.8 0.7 0.6 -1.9 0.5 0.7 2.0 0.4 -0.1 -1.5
Weight 0.7 3.2 7.1 1.9 1.8 1.0 2.2 2.7 -0.8 2.1 1.7 1.2
Impedance of arm (right) 1.0 4.8 9.9 -1.2 0.5 -2.8 -3.1 -3.1 2.0 -1.1 -1.8 -2.2
Arm fat percentage (right) 0.3 1.1 4.8 0.8 2.2 -1.1 -0.0 0.3 0.8 1.7 -0.1 -0.3
Trunk fat-free mass 1.0 6.0 16.2 2.0 0.3 2.8 3.1 4.0 -2.3 1.3 2.5 1.9
Hip circumference 0.4 1.9 4.0 1.0 2.0 1.0 1.2 1.7 -0.9 1.8 1.2 1.0
Time employed in main current job 2.0 2.3 10.8 -1.9 3.3 -0.7 -1.4 -0.1 0.8 -0.3 -1.1 -1.4
Alcohol intake versus 10 years previously 0.3 0.5 2.2 -0.6 0.2 0.8 0.6 -0.1 -0.8 -1.5 -0.7 0.2
Father’s age at death 0.1 0.2 0.8 0.0 -0.3 0.6 0.9 -0.2 0.2 -0.6 0.4 0.0
Worrier / anxious feelings 0.3 0.6 1.3 -0.1 0.9 -1.1 0.9 0.5 1.0 0.0 -0.2 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.3 1.4 -0.0 -0.7 0.6 1.1 0.4 1.5 1.1 -0.1
Falls in the last year 1.5 2.1 4.8 1.0 1.1 1.4 2.2 1.4 -1.4 1.4 1.3 1.4
Hair/balding pattern: Pattern 3 0.6 0.8 2.0 -0.8 0.4 -1.3 0.2 -0.9 1.0 -0.9 -0.7 -1.4
Number of live births 1.0 1.4 3.2 -0.9 1.5 -1.8 -1.7 -0.1 0.8 0.0 -1.1 -1.1
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.7 0.6 -0.1 1.2 -1.4 0.5 -1.6 0.5 -0.0 1.1
Pulse rate 0.3 0.6 1.6 0.6 1.0 -0.6 0.7 0.9 0.5 1.3 0.2 -0.2
Happiness 0.5 0.6 1.3 0.6 0.2 1.1 0.9 0.8 -0.7 0.6 0.8 1.0
Noisy workplace 0.8 1.0 3.4 0.5 0.6 -1.5 -1.9 0.6 0.7 1.1 0.2 -0.5
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.3 1.2 -1.0 1.4 1.5 1.0 -0.9 0.3 1.4 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.2 -0.8 -0.5 0.3 -1.0 -1.6 0.5 -1.8 -0.9 -0.4
Mouth/teeth dental problems: Dentures 1.1 1.9 5.5 1.8 -0.8 0.6 1.3 1.0 0.2 2.3 1.8 1.0
Asthma 1.6 3.2 9.5 0.5 -3.1 -2.3 0.1 -1.3 2.5 -0.9 -1.1 -1.9
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 3.8 -0.3 -0.3 1.9 1.5 1.0 -1.6 0.3 0.3 1.9
Medication: Cholesterol lowering 0.4 0.6 2.2 -0.2 0.7 1.5 0.8 0.6 -0.7 -0.5 0.8 0.4
Depression (self-reported) 0.4 0.5 2.8 0.8 -1.7 0.5 0.9 0.4 -0.3 -0.1 0.0 0.1
Medication: Lansoprazole 4.8 5.5 14.8 2.9 0.9 -2.7 1.5 2.5 2.2 3.9 2.0 -0.7
Prospective memory result 0.4 0.5 2.0 -0.2 0.6 -1.4 -0.4 0.0 0.8 0.5 -0.1 -1.0
Lung cancer (father) 1.1 1.3 4.6 -0.5 0.5 1.4 -1.3 0.3 -2.1 0.5 -0.2 1.7
Illnesses of mother 0.4 0.4 2.4 -0.4 -0.4 -0.4 -1.5 -0.2 -0.1 -0.6 -0.8 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 4.8 0.9 0.4 -0.3 -2.2 0.3 -0.5 0.9 -0.2 -0.0
Pulse wave Arterial Stiffness index 1.1 1.3 2.8 0.0 1.7 1.5 -0.5 1.2 -1.5 0.1 0.2 1.6
Impedance of arm (left) 0.8 3.6 8.6 -1.3 0.3 -2.2 -2.9 -2.9 1.4 -1.3 -1.7 -1.6
Arm fat mass (right) 0.3 1.3 3.5 1.2 1.9 0.4 1.0 1.4 -0.4 1.6 0.6 0.8
Trunk predicted mass 1.0 5.8 16.0 2.0 0.4 2.6 3.1 4.0 -2.2 1.4 2.4 1.8
Standing height 0.3 2.7 6.2 0.8 0.5 2.3 0.9 2.3 -2.5 0.0 1.6 1.8
Length of working week for main job 0.9 1.0 2.9 1.2 0.1 -0.2 0.8 1.2 0.4 1.7 1.5 0.3
Exposure to tobacco smoke at home 0.7 0.7 2.7 0.8 0.3 -1.0 0.2 0.2 1.0 1.6 0.9 -0.6
Breastfed as a baby 0.2 0.3 1.6 0.0 -1.3 -0.2 0.1 0.6 0.5 0.3 0.4 -0.0
Tense / ‘highly strung’ 0.1 0.2 0.9 0.2 -0.9 -0.4 0.3 -0.4 0.1 -0.2 -0.5 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.8 -0.4 -0.0 -0.2 -0.0 -0.8 0.0 -0.9 -0.4 -0.6
Hair/balding pattern: Pattern 4 0.2 0.4 1.5 0.1 -1.2 0.5 -0.3 -0.8 -0.3 -0.5 -0.5 0.6
Birth weight of first child 0.4 0.7 1.6 -0.4 0.9 1.2 0.6 -0.8 -0.9 0.6 0.5 1.3
Peak expiratory flow (PEF) 0.8 1.8 5.8 0.8 -1.0 1.8 -0.1 0.7 -2.2 0.5 0.3 2.4
Pulse wave reflection index 1.1 1.3 3.3 -0.7 0.7 1.8 -1.1 0.0 -1.8 -0.9 -0.5 1.5
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.0 -0.1 0.3 -0.8 -1.0 -0.5 0.6 0.1 -0.4 -0.6
Loud music exposure frequency 3.1 3.4 7.6 -1.7 -1.2 -0.5 -1.8 -2.6 0.5 -2.8 -2.4 -1.6
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.0 1.3 -0.3 0.9 1.7 1.6 -0.3 0.8 1.4 0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.1 -0.2 0.4 -1.0 -0.5 -0.9 0.6 -0.1 -0.9 -0.8
Blood clot in the leg (DVT) 0.8 1.0 2.2 1.3 -1.3 0.2 1.1 0.8 0.1 1.0 1.5 0.5
Medication: Paracetamol 0.2 0.3 1.2 -0.7 0.7 -0.3 -1.1 0.1 0.1 -0.2 -0.9 0.2
Headache pain in last month 3.5 6.0 9.5 2.4 -2.1 2.7 3.1 2.5 -2.2 1.5 2.7 2.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 0.3 -0.9 -1.0 -0.7 -0.2 0.7 0.3 -0.1 -0.5
Glaucoma (self-reported) 1.3 1.6 3.4 1.1 0.2 -1.7 -0.1 1.5 1.8 1.3 1.2 -1.0
Gout (self-reported) 1.2 1.7 3.0 1.5 1.7 0.4 1.7 1.7 -0.2 1.3 1.2 0.9
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 11.2 2.0 -3.4 -1.0 1.2 -0.9 2.2 1.1 1.2 -0.8
Medication: Amlodipine 0.9 1.2 2.7 -1.5 0.8 -0.8 -1.6 -1.0 0.2 -1.0 -1.3 -0.9
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.1 -0.8 -0.6 -1.1 -0.9 -1.1 1.0 -1.2 -1.1 -1.5
Birth weight 0.1 0.2 1.1 0.1 1.0 0.3 0.1 0.1 -0.3 -0.3 -0.2 0.3
Chronic bronchitis/emphysema (mother) 0.5 0.6 4.6 0.1 -2.1 0.6 -0.3 0.0 -0.4 0.2 0.2 0.3
High blood pressure (siblings) 0.2 0.4 1.2 -0.2 -0.1 0.4 -1.1 -0.5 -0.8 -0.3 -0.4 0.8
Forced vital capacity (FVC), Best measure 0.2 0.8 3.3 1.1 -0.3 0.5 -1.8 0.8 -1.0 0.5 0.2 0.4
Body fat percentage 0.3 1.3 5.1 0.6 2.2 -1.3 -0.3 -0.0 0.9 1.8 -0.1 -0.3
Leg fat percentage (right) 0.5 1.7 5.6 1.0 2.0 -1.6 -0.1 0.2 1.3 2.4 0.3 -0.7
Arm fat-free mass (right) 1.1 5.6 13.2 1.9 0.5 2.7 2.9 3.6 -2.3 1.4 2.3 2.3
Exposure to tobacco smoke outside home 0.2 0.3 1.0 0.1 -0.3 0.8 1.0 0.3 -0.3 -0.2 0.3 0.6
Comparative body size at age 10 0.6 1.5 3.5 1.9 0.2 1.0 0.9 1.9 -0.6 1.4 1.4 1.0
Number of full brothers 0.5 0.6 1.6 -0.2 0.2 0.5 -0.8 -1.3 -1.0 0.5 -0.9 0.8
Worry too long after embarrassment 1.5 2.5 5.9 1.9 -0.6 -1.1 1.9 1.2 1.5 2.4 1.9 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 2.4 0.6 -1.5 0.1 0.4 -0.2 0.0 -0.4 0.2 0.1
Wheeze or whistling in the chest in last year 0.1 0.1 0.4 -0.1 -0.7 -0.2 0.5 0.2 0.1 0.5 -0.2 -0.4
Number of children fathered 0.6 0.7 2.4 -1.0 0.1 1.5 0.4 -0.1 -1.3 -0.8 0.2 0.8
Reason for reducing amount of alcohol drunk: Health precaution 3.6 4.2 7.7 -1.7 0.1 -1.6 -2.4 -2.5 1.7 -2.3 -2.1 -2.8
Age at first live birth 0.6 1.1 4.6 -0.9 -0.8 1.4 0.7 -0.7 -0.7 -2.1 -0.3 0.1
Pulse wave peak to peak time 1.1 1.3 3.6 -0.3 -1.9 -1.2 0.4 -1.4 1.3 -0.6 -0.4 -1.6
Health satisfaction 1.3 1.6 7.0 1.1 -0.1 0.7 1.0 2.6 -0.4 1.1 1.6 1.0
Shortness of breath walking on level ground 0.6 0.8 3.1 0.7 0.6 -0.2 0.7 1.3 0.1 1.8 0.9 0.1
Qualifications: College or University degree 0.3 1.0 2.5 1.3 -1.1 0.2 1.0 1.0 0.3 1.1 1.6 0.4
Eye problems/disorders: None of the above 0.4 0.5 1.4 -0.3 0.3 1.2 -0.4 0.9 -1.1 -0.4 0.1 0.9
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.6 -1.5 -0.6 0.0 -0.3 -1.3 -0.1 -1.1 -1.6 -0.1
Emphysema/chronic bronchitis 0.9 1.0 3.5 0.8 -1.9 -1.0 0.3 -0.1 1.5 1.1 0.5 -0.5
Medication for pain relief, constipation, heartburn 0.2 0.4 1.2 0.3 0.1 -0.9 -0.6 -0.7 0.5 0.3 0.2 -1.1
Neck or shoulder pain in last month 0.6 0.8 2.8 0.8 0.5 0.9 1.7 0.8 -0.8 0.6 0.7 0.6
Medication: Blood pressure 0.6 1.0 3.8 0.2 0.3 1.5 2.0 0.6 -1.0 -0.0 0.4 1.0
Angina (self-reported) 0.5 0.6 2.2 0.2 1.1 1.0 0.9 0.2 -0.4 -1.5 -0.1 0.2
Migraine (self-reported) 1.2 1.5 4.0 0.6 -0.9 1.7 -0.0 0.6 -1.4 0.9 1.5 2.0
Medication: Ibuprofen 0.7 0.9 2.7 -0.7 -0.3 1.6 0.4 0.5 -1.4 -0.1 -0.2 1.5
Medication: Allopurinol 1.8 2.4 3.9 1.4 1.5 1.2 1.2 1.9 -1.1 1.9 1.5 2.0
Medication: Omeprazole 0.2 0.3 0.8 -0.1 -0.6 0.5 -0.2 0.9 -0.7 -0.1 0.1 0.8
Medication: Seretide 50 evohaler 0.4 0.4 2.7 0.1 -0.3 -0.2 1.6 0.9 0.3 0.0 -0.0 -0.2
Mean time to correctly identify matches 0.7 1.3 6.7 0.3 2.6 -1.2 -0.2 0.5 1.6 -0.2 -0.2 -0.9
Heart disease (mother) 0.7 0.8 3.4 1.0 0.4 -0.0 1.8 0.4 0.4 1.2 1.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.8 -0.4 -0.6 0.4 -0.1 -0.6 -0.8 -0.2 -0.2 0.9
Whole body fat mass 0.3 1.4 3.5 1.4 1.9 0.0 1.0 1.3 -0.2 1.9 0.8 0.6
Leg fat mass (right) 0.4 1.4 3.8 1.3 1.7 0.1 1.3 1.3 -0.0 2.0 0.8 0.5
Arm predicted mass (right) 1.5 7.6 17.6 2.4 0.4 2.9 3.5 4.2 -2.4 1.9 2.9 2.6
Pulse rate, automated reading 0.2 0.7 2.9 0.7 0.8 -0.9 -0.7 0.2 0.1 1.7 -0.7 0.7
Alcohol intake frequency. 0.2 0.5 2.0 1.1 0.1 0.3 1.4 0.6 -0.3 0.6 0.4 0.5
Comparative height size at age 10 0.1 0.5 1.8 -0.1 1.2 -0.8 -1.4 -0.1 0.3 0.2 -0.3 -0.6
Number of full sisters 0.5 0.6 1.5 1.2 -1.1 -0.6 -0.3 0.6 0.8 0.8 0.8 -0.2
Suffer from ‘nerves’ 1.2 2.0 4.7 1.4 0.1 -2.1 0.6 0.9 2.2 1.2 0.4 -1.8
Overall health rating 0.9 2.0 4.9 1.5 1.1 0.6 2.2 2.1 -0.5 1.4 1.1 1.1
Chest pain or discomfort 0.2 0.3 0.7 0.5 0.4 -0.7 0.8 -0.7 0.4 0.5 -0.5 -0.1
Had major operations 0.5 0.6 2.9 0.1 0.4 1.1 1.7 0.0 -0.9 0.1 0.2 0.5
Age at last live birth 0.9 1.2 2.0 -1.1 1.0 -0.9 -1.1 -1.2 0.6 -1.4 -1.2 -1.2
Family relationship satisfaction 0.3 0.4 1.4 -0.8 -1.2 0.9 0.1 0.5 -0.3 -0.8 0.2 0.0
Leg pain on walking 0.3 0.4 1.0 1.0 0.7 -0.0 0.8 1.0 0.1 0.3 0.8 0.3
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 3.6 0.9 1.2 0.9 0.9 1.9 -0.7 1.9 1.3 1.6
Commuting to job workplace: Car/motor vehicle 3.9 4.4 10.6 2.8 -0.1 -0.6 1.7 2.6 1.0 3.2 3.2 -0.1
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 5.6 -1.9 0.9 1.8 0.4 -0.2 -2.4 -0.9 -1.1 1.4
Medication: Aspirin 0.5 0.6 2.6 -0.1 0.7 1.6 0.9 0.3 -0.8 -0.4 0.5 0.9
Supplements: Vitamin C 1.0 1.2 3.5 -0.0 0.7 1.0 -0.1 0.8 -1.9 1.2 0.4 1.8
Knee pain experienced in last month 0.7 1.0 3.1 1.4 0.1 0.1 1.8 0.1 0.4 1.6 1.2 0.4
Hypertension (Self-reported) 0.5 1.3 3.6 0.8 1.9 0.8 1.0 0.7 -1.1 1.2 0.9 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.8 -0.3 0.7 -1.4 -0.6 -0.4 0.8 0.8 -0.3 -0.4
Illnesses of father: Heart disease 0.5 0.7 2.8 -0.2 1.7 -0.6 -0.5 -0.9 0.3 -0.9 -0.9 -0.6
Illnesses of siblings: Diabetes 1.0 1.2 7.5 -0.0 2.7 -0.8 -0.6 -0.6 0.5 0.8 -0.3 -1.1
Smoking status: Previous 0.2 0.3 0.8 0.5 -0.3 -0.9 -0.1 -0.3 0.8 0.9 -0.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.0 1.2 0.6 0.9 -0.3 1.4 -1.1 0.3 1.3 0.6
Whole body fat-free mass 1.1 6.4 16.3 2.2 0.5 2.7 3.3 4.0 -2.3 1.5 2.5 2.1
Leg fat-free mass (right) 1.1 6.1 13.5 2.2 0.8 2.9 3.0 3.7 -2.5 1.4 2.1 2.4
Arm fat percentage (left) 0.2 1.0 4.1 0.9 2.0 -0.7 0.2 0.5 0.5 1.7 0.1 0.1
Average weekly red wine intake 0.5 0.8 2.6 -1.6 0.2 0.9 0.4 -0.5 -0.7 -1.4 -0.7 0.2
Handedness (chirality/laterality): Left-handed 1.6 1.9 6.9 0.4 -2.6 1.4 2.5 0.5 -0.4 -0.5 0.7 0.5
Mood swings 0.5 0.8 2.2 -0.8 1.5 -1.2 0.2 0.3 1.2 -0.1 -0.3 -1.3
Loneliness, isolation 1.0 1.4 2.9 1.7 -1.2 1.3 0.1 1.6 -1.1 -0.0 0.6 1.4
Long-standing illness, disability or infirmity 0.6 0.9 2.3 1.5 0.0 -0.8 0.7 0.3 1.1 1.5 0.8 -0.3
Ever had bowel cancer screening 0.0 0.0 0.1 -0.2 0.3 -0.2 -0.2 -0.1 -0.1 0.1 -0.3 0.2
Diabetes diagnosed by doctor 0.5 0.8 6.3 -0.1 2.5 -0.4 -0.4 -0.0 0.6 0.5 -0.0 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 4.4 0.5 -2.1 -0.4 -0.1 -0.3 0.5 -0.8 -0.0 -0.4
Friendships satisfaction 0.5 0.6 2.3 -0.5 -1.5 0.9 -0.2 -0.6 -0.6 -1.1 -0.5 0.3
Qualifications: nursing, teaching 1.7 2.7 5.9 2.2 -1.4 0.3 2.4 1.6 0.4 1.9 2.1 0.7
Commuting to job workplace: Walk 1.2 1.3 2.8 -1.7 0.9 -0.1 -1.6 -0.9 -0.1 -1.2 -1.6 -0.7
Eye problems/disorders: Cataract 0.4 0.4 1.2 0.9 -0.9 -0.1 0.5 -0.8 0.2 1.1 0.5 0.1
Mouth/teeth dental problems: Mouth ulcers 3.1 5.0 13.3 -1.3 -0.1 -3.0 -3.7 -2.0 2.4 -0.2 -1.9 -2.7
Medication for cholesterol 0.8 1.2 3.5 -1.4 -0.1 1.1 -0.8 -0.4 -1.5 -1.9 -1.0 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.2 0.9 -0.8 -1.1 -0.2 -0.2 0.5 0.6 -0.2 0.4
Back pain experienced in last month 0.6 0.9 2.3 1.3 -0.2 0.5 1.1 0.6 -0.9 1.5 0.9 0.7
Mineral and other dietary supplements 0.6 0.8 1.8 0.9 -0.7 -1.0 -1.1 1.3 0.8 0.5 0.6 -0.7
Breast cancer (self-reported) 1.9 2.3 18.1 -0.8 4.3 -0.8 -0.6 0.5 0.4 -0.3 -0.6 -0.5
Asthma (self-reported) 1.5 3.0 11.8 0.5 -3.4 -2.0 0.2 -1.2 2.2 -0.9 -0.9 -1.7
Osteoporosis (self-reported) 0.6 0.8 2.0 0.8 -1.4 0.9 1.1 0.7 -0.7 -0.8 0.6 0.7
Osteoarthritis (self-reported) 3.1 4.0 7.0 1.7 -1.6 2.0 2.6 2.2 -1.1 1.6 2.4 2.2
Medication: Aspirin 0.4 0.5 1.9 -0.3 0.7 1.4 1.1 0.4 -0.4 -0.4 0.5 0.6
Medication: Gliclazide 0.6 0.7 2.2 0.3 -0.5 1.5 -0.2 0.2 -1.4 -0.1 0.3 1.3
Illnesses of father: None of the above (group 1) 0.5 0.6 2.0 0.7 -0.5 0.2 0.2 1.4 -0.3 1.2 1.0 0.6
Smoking status: Current 0.5 0.8 1.8 -1.2 0.8 1.0 -0.8 0.0 -1.0 -1.3 -0.9 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.6 0.3 0.7 -0.5 -1.6 0.1 0.4 0.4 -0.4 -0.7
Whole body water mass 1.1 6.1 15.7 2.2 0.6 2.7 3.1 4.0 -2.3 1.5 2.4 2.1
Leg predicted mass (right) 1.1 6.0 13.5 2.3 0.7 2.8 3.0 3.7 -2.4 1.4 2.1 2.4
Arm fat mass (left) 0.4 1.6 3.6 1.4 1.8 0.4 1.0 1.6 -0.5 1.9 0.8 1.0
Number of self-reported non-cancer illnesses 1.2 2.1 5.1 2.3 -1.3 -1.2 1.0 1.0 1.8 1.6 1.7 -0.3
Average weekly champagne plus white wine intake 0.4 0.6 2.7 -0.8 0.3 1.0 0.3 -0.4 -0.8 -1.7 -0.4 -0.0
Miserableness 1.0 1.8 7.6 -0.3 2.8 -1.4 0.4 0.9 1.3 0.5 0.1 -1.9
Guilty feelings 0.1 0.2 0.9 0.9 -0.4 0.1 0.2 0.5 0.5 -0.2 0.3 0.1
Wears glasses or contact lenses 0.2 0.2 0.8 0.3 -0.8 0.2 -0.3 0.5 -0.2 -0.1 -0.0 0.9
Ever taken oral contraceptive pill 0.3 0.3 0.7 0.5 -0.3 -0.4 0.4 0.4 0.6 0.4 0.7 -0.8
Hearing aid user 0.8 1.0 2.2 0.8 -0.0 -1.2 0.9 0.7 1.5 1.0 1.2 -0.7
Mother’s age at death 0.9 1.2 3.2 -1.8 -1.1 0.4 -0.4 -1.5 -0.3 -1.1 -1.5 0.0
Financial situation satisfaction 1.8 2.2 5.7 0.7 0.4 1.8 2.4 2.3 -1.1 -0.2 1.3 1.3
Tinnitus: Yes, now most or all of the time 1.0 1.1 2.4 1.6 -1.1 -1.3 -1.5 -0.2 1.2 0.3 0.2 -1.1
Commuting to job workplace: Public transport 1.4 1.7 6.9 -0.5 -2.1 0.7 0.7 -0.8 -0.1 -2.6 -1.3 0.3
Eye problems/disorders: Glaucoma 1.5 1.8 3.5 1.4 0.5 -1.7 0.1 1.4 1.8 1.9 1.5 -0.8
Medication: Blood pressure 0.2 0.4 2.1 0.4 1.4 -0.3 0.0 -0.3 0.0 0.8 0.1 0.3
Pain type(s) experienced in last month: Hip pain 1.8 2.3 5.1 1.2 -1.0 1.9 2.2 0.2 -1.3 1.3 1.3 2.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 2.0 -0.0 -0.4 -0.0 1.4 -0.7 0.5 0.2 -0.0 -0.0
High cholesterol (Self-reported) 0.4 0.8 6.4 0.4 2.5 -0.2 0.0 0.6 0.1 0.4 0.2 0.1
Medication: Bendroflumethiazide 2.3 3.5 6.7 2.6 -0.8 -1.9 1.9 -0.2 2.5 2.3 1.9 -1.2
Medication: Paracetamol 0.4 0.6 2.0 -1.0 0.2 -0.5 -1.2 -0.3 0.3 -0.3 -1.4 -0.1
Medication: Lisinopril 1.7 2.2 4.0 1.4 1.8 -0.7 2.0 1.6 0.5 2.0 1.8 -0.1
Medication: Atorvastatin 1.8 2.2 6.6 1.4 -0.3 1.6 2.6 1.6 -1.2 0.7 1.4 1.4
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.1 0.2 -0.5 -0.2 -0.0 0.4 -0.2 -0.3 -0.3
Alcohol drinker status: Never 0.3 0.4 2.3 0.9 0.1 -0.4 -0.2 -0.1 0.4 1.5 0.3 -0.2
Ever smoked 0.9 1.5 3.8 -1.3 -0.2 0.1 -1.5 -1.9 -0.4 -1.4 -2.0 0.3
Basal metabolic rate 1.0 5.3 13.4 2.1 0.8 2.4 2.9 3.7 -2.0 1.6 2.2 1.9
Leg fat percentage (left) 0.4 1.5 5.6 0.5 2.4 -1.4 -0.5 -0.0 1.0 2.0 -0.1 -0.6
Arm fat-free mass (left) 1.0 5.2 12.7 2.1 1.0 2.2 2.9 3.6 -1.9 1.8 2.3 1.9
Number of operations (self-reported) 0.7 1.0 2.6 -0.2 0.4 1.4 1.2 -0.3 -1.6 -0.7 -0.6 1.6
Average weekly beer plus cider intake 0.7 1.0 3.5 1.2 -0.9 0.3 -0.3 1.9 -0.3 1.4 1.0 0.4
Irritability 1.0 1.7 5.8 0.3 0.2 -2.1 0.7 -0.5 2.4 0.9 -0.3 -1.9
Risk taking 1.6 2.3 5.3 2.3 -2.2 0.2 1.3 0.8 0.3 1.9 1.8 1.0
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.7 -0.6 -0.2 1.2 0.5 0.1 -1.6 -0.5 -0.2 0.8
Fractured/broken bones in last 5 years 0.8 1.1 3.0 0.7 -1.2 1.1 1.7 0.8 -0.6 0.8 1.1 0.9
Age started oral contraceptive pill 0.4 0.5 2.2 -0.5 -0.2 -0.6 -0.8 -1.5 0.8 -0.5 -0.6 -0.5
Diastolic blood pressure, automated reading 0.2 0.6 2.5 1.2 0.1 -0.8 0.1 0.3 0.5 1.6 0.5 0.3
Ever depressed for a whole week 1.9 2.3 5.1 -1.9 -0.4 1.5 -0.0 -2.1 -1.5 -2.3 -1.5 0.4
Unable to work because of sickness or disability 0.3 0.4 1.3 0.8 -0.6 -0.9 -0.0 0.0 0.8 0.3 -0.2 -1.1
Commuting to job workplace: Cycle 1.0 1.2 6.9 -0.9 -2.6 0.2 -0.2 -0.8 0.3 -1.0 -0.6 -0.7
Myopia 0.6 0.9 3.2 -0.2 -1.1 1.8 1.1 -0.3 -1.0 -0.5 0.2 0.9
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.5 -0.9 -1.6 -0.6 -1.3 -0.6 0.7 -1.0 -1.0 -1.1
Cholesterol lowering medication 0.3 0.4 2.1 0.6 1.5 -0.5 -0.1 0.4 0.5 0.8 0.2 0.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.7 -0.3 -0.3 -0.4 -0.8 -0.1 -0.0 -0.2 -0.5 0.0
Pain experienced in last month 0.6 1.0 3.1 -0.7 0.3 -0.7 -1.8 -0.7 1.0 -1.4 -0.8 -0.8
Supplements: Calcium 1.1 1.2 2.6 1.1 -0.5 1.1 0.8 1.4 -0.8 0.9 1.6 1.4
Basal cell carcinoma (self-reported) 1.0 1.2 3.6 -0.5 -0.4 1.9 1.2 -0.3 -1.7 -1.2 0.1 1.1
Heart attack/myocardial infarction (self-reported) 5.3 6.8 18.5 1.4 -1.1 4.3 3.2 1.4 -3.4 -0.1 1.8 3.5
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 3.1 1.5 -1.4 0.4 1.4 0.9 -0.0 1.3 1.8 0.7
Heart disease (siblings) 0.5 0.6 2.4 1.6 0.6 0.0 1.0 0.3 -0.3 0.7 0.4 0.7
Alcohol drinker status: Previous 0.7 0.7 2.3 1.0 -1.5 -0.3 0.6 0.2 0.4 1.5 0.6 0.4
Pack years of smoking 1.1 1.6 3.7 1.2 -1.2 0.4 1.9 1.7 -0.4 1.1 1.6 1.0
Impedance of whole body 1.0 5.0 12.4 -1.4 0.1 -2.8 -3.5 -3.3 1.9 -0.9 -1.7 -2.0
Leg fat mass (left) 0.3 1.3 3.8 1.1 2.0 0.2 1.0 1.2 -0.3 1.8 0.6 0.6
Arm predicted mass (left) 1.1 5.8 14.7 2.3 0.8 2.2 3.1 3.8 -1.8 2.0 2.5 2.0