TWAS hub - JAK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0230	3.9e-07	0.104	0.075	0.096	0.101	0.108	1.4e-12	2.1e-09	1.0e-11	3.1e-12	4.7e-13
2	GTEx	Brain Cerebellar Hemisphere	0.4410	0.0860	1.7e-06	0.241	NA	0.230	NA	0.207	7.0e-07	NA	1.3e-06	NA	4.9e-06
3	GTEx	Brain Cerebellum	0.4840	0.0820	9.9e-09	0.268	NA	0.388	NA	0.361	1.5e-08	NA	1.6e-12	NA	1.5e-11
4	GTEx	Brain Cortex	0.3380	0.0900	3.0e-04	0.211	NA	0.172	NA	0.232	1.7e-06	NA	1.7e-05	NA	4.6e-07
5	GTEx	Thyroid	0.1370	0.0470	7.4e-04	0.000	NA	0.025	NA	0.002	2.9e-01	NA	5.0e-03	NA	2.0e-01
6	NTR	Blood	0.0192	0.0082	4.6e-03	0.002	0.006	0.003	0.007	0.001	6.8e-02	4.0e-03	3.5e-02	2.1e-03	1.1e-01
7	ROSMAP	Brain Pre-frontal Cortex	0.1192	0.0268	6.1e-11	0.126	0.088	0.112	0.120	0.117	6.2e-16	2.1e-11	3.2e-14	3.6e-15	7.4e-15
8	YFS	Blood	0.0215	0.0080	9.1e-04	0.006	0.009	0.004	0.009	0.009	4.6e-03	3.1e-04	1.4e-02	4.3e-04	3.5e-04
9	TCGA	Cervical Squamous Cell Carcinoma	0.0940	0.0520	2.9e-03	0.082	0.025	0.053	NA	0.073	7.5e-05	2.2e-02	1.3e-03	NA	1.8e-04
10	TCGA	Brain Lower Grade Glioma	0.0820	0.0292	5.1e-09	0.081	0.076	0.061	NA	0.075	1.8e-09	5.2e-09	1.9e-07	NA	6.5e-09
11	TCGA	Prostate Adenocarcinoma	0.0398	0.0210	2.5e-03	0.005	0.015	0.011	NA	0.005	8.0e-02	9.2e-03	2.4e-02	NA	9.5e-02
12	TCGA	Thyroid Carcinoma	0.0760	0.0310	1.2e-06	0.063	0.051	0.059	NA	0.054	1.0e-06	1.0e-05	2.0e-06	NA	5.7e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Medication: Lansoprazole	9.4	10.7	18.8	4.2	4.3	3.8	4.3	1.8	2.2	3.8	3.1	3.0	4.1	-0.7	0.2
Commuting to job workplace: Car/motor vehicle	5.1	5.9	13.9	3.7	2.2	3.2	3.3	2.9	-0.4	3.5	0.1	1.3	2.4	0.6	1.5
Commuting to job workplace: Public transport	5.1	6.0	11.6	-2.8	-3.3	-3.0	-2.6	-0.9	-1.0	-2.7	0.2	-2.9	-3.4	2.5	1.7
Blood Eosinophil Count	4.6	35.7	98.8	-7.0	-8.6	-5.8	-6.1	-4.5	3.7	-6.7	-9.9	0.7	-7.5	-0.3	-0.1
Alcohol usually taken with meals	4.0	6.5	13.9	-3.1	-2.2	-3.2	-3.0	0.3	-3.7	-3.0	-1.4	-2.2	-3.5	1.0	0.9
Ever depressed for a whole week	2.9	3.6	9.0	-3.0	-1.5	-2.3	-3.0	-0.7	-0.8	-2.6	-0.5	-1.6	-2.4	-0.3	-0.8
Loud music exposure frequency	2.7	3.0	7.6	-1.7	-1.6	-2.0	-2.2	-2.1	0.1	-2.2	1.4	-2.8	-1.0	-0.3	-1.2
Ulcerative Colitis	2.6	3.8	10.5	-2.4	-2.3	-1.8	-2.1	-1.6	0.3	-2.3	-3.2	0.0	-2.3	-0.8	-1.6
Neuroticism (2016)	2.5	3.5	7.5	2.5	1.3	2.4	2.5	1.9	0.2	2.2	2.7	1.3	1.6	0.7	1.4
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	4.8	-2.0	-2.2	-1.8	-2.1	-1.8	0.8	-2.1	-0.4	-1.9	-1.8	0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	5.6	-2.0	-1.7	-2.4	-2.1	-2.1	0.6	-2.2	0.1	-1.6	-1.5	-0.7	-0.9
Age at first live birth	2.3	4.1	7.8	-2.1	-1.7	-2.1	-2.1	-0.5	-2.8	-2.0	-0.6	-2.6	-2.6	2.0	1.8
Back pain experienced in last month	2.2	3.3	6.2	2.1	1.8	2.5	2.1	0.3	2.3	2.3	1.5	1.6	2.4	-0.3	-0.2
Heart attack/myocardial infarction (self-reported)	2.2	2.8	7.2	-0.8	-1.9	-1.0	-0.8	2.4	-2.5	-0.3	-1.2	-0.8	-1.7	2.1	2.7
Blood Platelet Count	2.1	24.0	46.8	6.6	4.2	6.8	6.8	4.7	1.2	6.8	2.4	5.2	5.6	-0.1	0.5
Shortness of breath walking on level ground	2.1	2.5	6.2	1.3	1.3	1.5	1.5	-0.2	1.7	1.3	0.8	2.5	2.0	-2.1	-1.6
Average weekly champagne plus white wine intake	2.1	2.8	6.6	-1.9	-2.4	-1.7	-2.0	-0.6	0.2	-1.8	-2.6	-1.5	-2.1	0.9	0.4
Lung cancer (father)	2.0	2.3	6.5	0.7	2.0	1.4	1.0	0.3	1.1	0.7	-0.6	1.6	2.0	-2.4	-2.5
Eye problems/disorders: Glaucoma	2.0	2.4	4.5	2.0	1.4	2.0	1.9	1.1	1.1	2.1	1.4	1.3	1.9	0.1	0.4
Pain all over the body in last month	1.9	2.0	7.8	-0.5	-0.6	-0.4	-0.3	-2.0	2.2	-0.5	-0.1	0.6	0.7	-2.4	-2.8
Hearing difficulty/problems: Yes	1.8	2.7	14.4	-0.1	-0.7	0.5	0.1	-2.4	3.8	-0.1	-0.5	1.2	0.9	-2.3	-2.0
Qualifications: None of the above	1.8	3.9	12.4	-0.2	-0.3	-0.2	-0.3	-3.0	3.5	-0.7	1.2	0.0	1.8	-2.8	-3.4
Heart attack	1.8	2.3	5.5	-0.7	-1.9	-0.9	-0.6	2.2	-2.4	-0.3	-1.2	-0.5	-1.5	1.7	2.3
Leg fat percentage (right)	1.8	6.6	15.5	2.9	1.7	2.5	2.9	-0.6	3.9	2.5	0.8	2.7	3.6	-2.4	-2.2
Mouth/teeth dental problems: Loose teeth	1.8	2.2	5.2	-2.1	-1.0	-1.5	-1.6	-2.1	0.9	-2.3	-0.8	0.1	-1.3	-1.0	-1.4
Suffer from ‘nerves’	1.8	2.8	7.8	1.9	1.7	2.0	2.0	0.8	2.0	1.7	2.8	0.9	1.9	0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	5.0	1.8	2.2	1.7	1.7	1.6	0.3	1.8	0.9	1.4	1.8	-0.5	-0.1
Leg fat percentage (left)	1.8	6.5	16.5	2.6	1.5	2.3	2.5	-1.0	4.1	2.2	0.4	2.6	3.5	-2.9	-2.7
Average weekly beer plus cider intake	1.8	2.6	5.8	2.1	0.7	2.0	2.1	1.2	1.5	2.4	1.6	1.1	2.2	0.5	0.2
Basal cell carcinoma (self-reported)	1.8	2.2	9.2	-1.4	-0.4	-1.6	-1.6	1.0	-3.0	-1.4	-0.2	-1.8	-1.5	0.7	0.7
Coronary Artery Disease (CAD)	1.7	2.1	7.6	1.0	1.6	0.9	0.7	-0.6	0.3	1.1	0.7	1.0	1.9	-2.8	-2.4
Mean Putamen Volume	1.7	1.9	5.3	0.8	1.7	1.2	0.7	-0.4	0.8	0.5	1.4	0.2	1.9	-2.3	-2.3
Primary Biliary Cirrhosis	1.7	2.4	8.5	-1.4	-1.0	-1.8	-1.3	-0.2	-0.3	-1.5	-2.9	-1.1	-2.2	1.6	0.9
Illnesses of siblings	1.7	2.3	7.1	-0.3	-1.1	-0.2	-0.3	1.9	-2.3	-0.1	-1.3	-0.3	-1.6	2.5	2.7
Exposure to tobacco smoke at home	1.7	1.9	5.7	1.5	0.5	1.8	1.7	0.5	2.4	1.3	0.3	1.7	1.8	-0.9	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	10.4	0.1	-0.1	0.5	0.2	-2.2	2.3	-0.5	0.1	0.9	1.2	-3.2	-2.9
Blood White Count	1.6	11.5	45.6	-0.4	-3.0	0.4	-0.1	-3.4	4.5	-0.2	1.7	2.5	2.1	-6.8	-6.1
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.8	0.9	2.2	1.4	0.7	-0.3	0.8	1.1	0.6	1.2	1.6	-1.8	-1.8
Angina (self-reported)	1.6	2.1	3.7	-1.7	-1.5	-1.9	-1.8	-0.5	0.3	-1.5	-0.5	-1.7	-1.7	1.3	1.5
Myopia	1.6	2.4	5.4	-2.0	-1.6	-1.4	-1.6	1.1	-2.0	-1.8	-1.3	-0.3	-2.3	0.6	1.3
Intelligence (Savage-Jansen 2018)	1.5	4.5	12.1	2.3	-0.0	2.2	2.3	3.5	-2.1	2.5	-0.8	1.1	0.3	2.4	2.7
Diabetes (father)	1.5	1.9	5.6	1.2	0.8	1.8	1.3	0.5	2.4	1.6	1.8	1.0	1.6	-0.2	-0.5
Financial difficulties in last 2 years	1.5	2.0	5.8	1.0	-1.4	0.9	0.8	2.0	1.2	1.2	-1.1	-0.0	-0.4	2.4	2.4
Father’s age at death	1.5	2.0	4.5	-1.6	-1.2	-1.4	-1.5	0.6	-2.1	-1.6	-1.1	-1.0	-1.9	1.0	1.2
Headache pain in last month	1.5	2.6	11.0	1.3	1.1	1.3	1.3	3.3	-1.3	1.6	0.1	0.4	0.1	2.0	2.2
Illnesses of siblings: Diabetes	1.5	1.8	4.0	0.8	1.4	1.1	0.9	-0.5	1.8	0.7	0.5	1.4	1.7	-2.0	-2.0
Major Depression (MDD)	1.4	1.7	3.7	1.7	1.1	1.6	1.8	1.0	1.9	1.5	0.6	1.1	1.5	0.5	0.3
Pack years adult smoking proportion	1.4	2.2	5.6	2.0	1.1	1.4	1.7	2.4	-0.9	1.9	0.9	0.2	1.2	1.3	1.3
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	5.5	-2.3	-0.6	-1.2	-2.1	0.5	-0.9	-1.6	-1.0	0.2	-1.6	-0.5	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	3.9	1.9	1.5	2.0	1.9	0.7	2.0	1.7	1.5	1.1	1.6	-0.2	-0.0
Falls in the last year	1.4	1.9	4.6	1.9	1.2	1.6	1.7	0.7	1.2	1.9	0.9	1.0	2.1	-0.9	-0.5
Medication: Levothyroxine sodium	1.3	2.1	7.4	-0.9	-2.7	-0.9	-0.8	-1.9	1.9	-0.9	-1.6	0.2	-1.6	1.0	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	6.2	2.2	0.9	1.9	2.0	2.5	0.3	2.3	-0.7	0.3	0.7	2.1	2.4
Fluid intelligence score	1.3	2.6	6.8	1.1	-0.1	1.3	1.2	2.4	-2.0	1.6	-1.5	0.8	-0.6	2.3	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	9.2	2.8	3.0	3.0	2.8	-0.0	1.5	2.2	1.4	0.6	2.6	-0.2	-1.0
Length of working week for main job	1.3	1.4	3.2	1.6	0.4	1.8	1.7	0.9	1.3	1.6	0.1	1.0	1.3	0.2	0.6
Body fat percentage	1.3	5.1	11.8	2.5	0.6	2.0	2.4	-0.8	3.4	2.1	1.3	1.8	3.2	-2.6	-2.5
Number of full brothers	1.3	1.7	4.4	-0.3	0.5	0.7	0.0	-1.1	2.0	0.2	-0.5	2.1	1.1	-2.0	-2.0
Medication: Allopurinol	1.3	1.7	4.0	1.1	1.2	1.9	1.5	1.6	1.0	1.2	-0.6	2.0	1.3	-1.0	0.0
Miserableness	1.3	2.3	5.6	1.2	2.0	1.9	1.4	0.9	1.6	0.9	2.4	0.7	1.9	-1.1	-1.1
Medication: Lisinopril	1.3	1.7	3.8	1.8	1.1	1.6	1.9	0.4	0.8	2.0	0.5	1.1	1.8	-0.4	0.5
Commuting to job workplace: Cycle	1.3	1.6	3.6	-1.6	-1.9	-1.9	-1.3	-0.4	-0.7	-1.5	-1.0	-0.3	-1.8	0.8	0.4
Pain experienced in last month	1.3	2.1	6.4	-1.6	-2.5	-1.9	-1.5	-1.0	-1.0	-1.4	-0.8	-1.3	-1.6	1.0	0.6
Verbal and Numeric Reasoning (VNR)	1.2	2.8	7.4	1.1	0.2	1.1	1.2	2.7	-2.4	1.5	-1.2	0.6	-0.4	2.5	2.6
Mouth/teeth dental problems	1.2	1.8	7.7	-0.9	-0.4	-0.9	-1.0	1.4	-2.8	-0.5	0.3	-1.7	-1.5	1.6	1.2
Arm fat percentage (right)	1.2	4.8	12.1	2.6	0.8	2.1	2.4	-0.8	3.5	2.1	1.0	1.6	3.0	-2.3	-2.3
Time employed in main current job	1.2	1.4	6.1	-0.3	1.0	-0.2	-0.1	-1.2	1.0	-0.2	1.2	1.0	1.2	-2.5	-1.9
Noisy workplace	1.2	1.4	4.0	1.6	1.1	1.4	1.4	-0.6	1.3	1.3	-0.0	1.0	2.0	-0.6	-0.8
Asthma	1.2	2.5	8.3	-1.1	-2.9	-1.7	-1.3	-2.2	1.2	-1.0	-0.1	-1.5	-1.6	1.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.5	1.0	0.3	0.8	1.0	0.0	1.2	0.4	1.4	1.3	1.8	-2.1	-1.3
Qualifications: nursing, teaching	1.2	1.8	7.1	0.7	-1.1	0.3	1.1	1.1	-0.2	0.9	-2.7	1.3	-0.8	1.8	2.0
Asthma (self-reported)	1.2	2.4	8.2	-1.2	-2.9	-1.8	-1.3	-2.1	1.0	-1.0	-0.2	-1.5	-1.6	1.6	0.9
Osteoporosis (self-reported)	1.2	1.5	6.0	0.1	-0.9	-0.5	-0.2	0.8	-1.2	-0.1	0.7	-1.9	-0.7	2.5	2.1
Mother’s age at death	1.2	1.5	3.8	-1.7	-0.6	-1.2	-1.2	-1.2	-0.1	-1.9	-0.1	0.3	-1.2	-1.4	-1.6
Financial situation satisfaction	1.2	1.5	4.3	-0.9	-0.7	-0.6	-0.7	1.8	-1.1	-0.7	-1.0	-0.5	-1.4	1.7	2.1
Ulcerative Colitis (UC)	1.1	2.1	5.8	-1.8	-1.4	-1.2	-1.4	-1.1	-0.6	-1.3	-2.4	1.1	-1.5	-1.3	-1.3
Hypothyroidism (self reported)	1.1	2.6	7.8	-0.1	-2.8	-0.3	-0.1	-0.4	1.1	0.3	-2.8	1.1	-1.8	2.0	2.4
Neuroticism	1.1	2.6	9.7	1.6	1.3	1.9	1.6	-0.4	2.7	1.1	3.1	0.5	1.6	-0.0	-0.3
Angina	1.1	1.4	2.7	-1.4	-1.3	-1.7	-1.4	-0.8	0.8	-1.3	-0.3	-1.4	-1.3	1.0	1.1
Medication for hormone replacement therapy	1.1	1.2	3.1	1.6	0.6	1.2	1.8	0.7	-0.3	1.5	-0.7	1.6	0.9	0.6	0.4
Maternal smoking around birth	1.1	1.6	5.3	1.3	2.3	1.7	1.4	0.5	0.4	1.3	0.3	1.4	1.6	-0.7	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.3	1.2	1.8	1.8	1.1	0.0	0.9	1.2	1.0	0.8	1.8	-0.8	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.8	1.4	2.2	1.6	1.2	1.3	0.4	1.2	2.0	0.2	1.5	0.2	-0.5
Qualifications: A levels/AS levels or equivalent	1.1	2.5	11.7	-0.3	-1.7	-0.9	-0.5	0.6	-3.4	0.1	-1.2	-1.1	-1.5	2.0	2.2
Glaucoma (self-reported)	1.1	1.3	2.7	1.5	0.9	1.2	1.3	1.6	0.3	1.6	1.1	0.3	1.2	0.7	0.8
Worry too long after embarrassment	1.1	1.8	4.7	1.4	0.9	1.7	1.8	1.2	1.7	1.6	-0.2	2.2	1.0	0.4	0.2
Leg fat mass (right)	1.1	4.1	8.6	2.7	1.8	2.4	2.6	0.3	2.4	2.3	0.8	1.7	2.9	-1.4	-1.2
Pulse rate, automated reading	1.1	3.7	7.0	2.2	0.3	1.5	2.2	-1.5	1.5	1.9	1.5	2.3	2.6	-2.1	-2.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.9	-1.1	-1.4	-1.5	-1.1	0.6	-1.7	-1.0	-1.0	-0.6	-1.7	0.6	0.9
Long-standing illness, disability or infirmity	1.1	1.6	10.1	1.3	0.0	1.1	1.1	-1.0	3.2	1.1	0.2	0.8	1.3	-0.8	0.0
Supplements: Calcium	1.1	1.2	4.0	-0.2	0.2	0.1	0.0	1.6	-2.0	0.1	-1.6	0.6	-0.8	1.0	1.8
Schizophrenia (2014)	1.0	2.2	9.8	-0.6	0.6	0.1	-0.6	-1.4	0.6	-0.9	1.0	0.3	1.0	-3.1	-3.1
BMI	1.0	5.7	10.8	3.2	2.9	2.9	3.0	0.8	2.8	3.0	0.8	1.5	3.3	-1.0	-0.7
Lung FEV1/FVC ratio	1.0	5.0	15.3	3.0	2.5	2.4	2.7	1.3	-0.4	2.5	3.9	-0.1	2.8	0.0	0.1
Frequency of depressed mood in last 2 weeks	1.0	1.4	6.2	1.3	1.6	1.3	0.9	0.1	0.6	1.2	2.5	-0.1	1.4	0.6	-0.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	6.2	-0.3	-0.5	-0.6	-0.4	0.3	-0.7	-0.4	0.6	-1.4	-1.0	1.9	2.5
Severe depression (siblings)	1.0	1.1	2.4	-1.5	-1.4	-1.1	-1.2	-1.1	0.5	-1.5	-0.3	0.1	-0.9	-1.0	-0.9
Serious illness, injury or assault to yourself	1.0	1.2	9.0	1.0	-0.3	0.7	0.9	-1.3	3.0	0.8	0.7	-0.2	0.7	0.2	0.3
Number of live births	1.0	1.4	5.6	1.0	0.3	0.9	0.6	-0.9	2.4	0.9	0.3	0.6	1.6	-1.5	-1.6
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.9	-0.5	-2.4	-0.4	-0.3	-0.7	0.8	-0.1	-2.4	0.7	-1.7	1.7	2.2
Supplements: Vitamin C	1.0	1.1	2.3	1.0	0.9	1.5	1.3	1.1	0.5	1.4	-0.5	1.5	1.2	-0.6	-0.4
Arm fat percentage (left)	1.0	4.1	8.5	2.6	0.8	2.0	2.4	-0.3	2.8	2.1	1.1	1.3	2.9	-2.0	-2.1
Average weekly red wine intake	1.0	1.4	2.9	-1.7	-1.2	-1.6	-1.6	-0.1	-1.6	-1.5	0.5	-1.0	-1.2	-0.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.9	-0.2	-0.1	0.1	-0.4	0.2	0.7	-0.4	-0.6	-1.4	-1.2	2.2	1.6
Friendships satisfaction	1.0	1.2	2.7	-1.4	-0.8	-1.0	-1.1	0.1	-1.3	-1.5	-1.1	-0.9	-1.6	0.7	0.6
Osteoarthritis (self-reported)	1.0	1.4	4.4	0.6	0.5	0.8	0.8	2.1	-1.9	0.8	-0.8	0.9	-0.1	1.2	1.7
Arm fat mass (left)	1.0	4.1	8.6	2.9	1.8	2.5	2.7	0.7	1.8	2.5	0.9	1.2	2.9	-1.2	-1.2
Alcohol drinker status: Never	1.0	1.2	4.5	0.4	0.9	0.7	0.8	-0.6	1.4	0.7	-1.2	2.1	1.1	-1.1	-1.2
Pack years of smoking	1.0	1.4	4.0	1.6	0.6	1.0	1.4	2.0	-0.9	1.6	0.9	0.2	1.1	1.0	1.0
Leg fat mass (left)	1.0	4.1	8.5	2.6	1.9	2.3	2.5	0.2	2.5	2.2	0.6	1.6	2.9	-1.5	-1.4
Neuroticism (Nagel 2018)	0.9	2.0	5.5	1.5	0.5	1.9	1.7	0.1	2.3	1.1	2.3	1.2	1.3	-0.4	-0.1
Schizophrenia vs Biploar Disorder	0.9	1.2	2.8	-1.5	-1.7	-1.4	-1.5	-0.9	-0.4	-1.2	0.8	-0.7	-0.8	-0.8	-1.1
Age at First Birth	0.9	1.3	5.1	-1.2	0.0	-0.7	-1.5	-1.1	-2.2	-1.0	0.9	-1.4	-1.0	0.2	0.1
Age when periods started (menarche)	0.9	2.1	3.8	-1.9	-2.0	-1.7	-1.7	-1.6	-1.1	-1.6	-0.1	-0.7	-1.9	0.8	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.7	1.5	-0.1	1.1	1.3	2.4	-0.3	1.6	-1.3	0.1	-0.0	1.9	2.4
Medication: Atenolol	0.9	1.1	4.1	0.6	0.3	1.0	0.7	2.0	0.7	0.9	-1.5	1.5	0.3	0.9	0.9
Body mass index (BMI)	0.9	3.9	7.6	2.7	1.9	2.3	2.5	0.5	2.3	2.3	0.2	1.8	2.8	-1.2	-0.9
Waist circumference	0.9	3.4	8.1	2.9	1.7	2.3	2.7	1.2	0.6	2.6	0.6	1.5	2.5	-0.5	-0.3
Diabetes (self-reported)	0.9	1.4	3.7	0.5	0.5	0.7	0.3	-1.7	1.8	0.6	0.5	0.5	1.4	-1.9	-1.6
Neuroticism score	0.9	1.9	9.0	1.2	1.5	1.6	1.3	0.4	1.9	0.7	3.0	0.1	1.1	0.2	-0.1
Weight	0.9	4.2	8.9	3.0	2.6	2.8	2.8	1.2	1.2	2.7	0.4	1.3	2.6	-0.2	-0.0
Mouth/teeth dental problems: Dentures	0.9	1.6	4.3	1.4	0.2	1.2	1.6	0.9	1.3	1.5	-1.3	2.1	1.0	0.4	1.0
Medication: Amlodipine	0.9	1.3	4.8	-0.6	-0.3	-0.5	-0.7	-1.8	0.3	-0.9	1.2	-0.6	0.6	-2.2	-1.8
Number of children fathered	0.9	1.0	2.1	-1.2	-0.3	-1.3	-1.2	1.2	-1.4	-1.3	-0.8	-0.8	-0.9	-0.3	-0.1
Pulse wave peak to peak time	0.9	1.1	6.1	-0.8	-2.5	-0.9	-0.8	-0.7	0.0	-0.6	-0.2	-0.3	-1.2	1.0	1.0
Health satisfaction	0.9	1.2	3.1	1.3	0.7	1.6	1.1	1.8	-0.5	1.0	1.4	-0.2	1.3	-0.3	0.5
Whole body fat mass	0.9	4.0	8.3	2.8	1.5	2.3	2.6	0.5	2.2	2.4	1.0	1.4	2.9	-1.2	-1.1
Arm predicted mass (right)	0.9	4.7	11.1	2.6	3.3	2.7	2.4	3.1	-1.3	2.5	0.1	0.6	1.7	1.4	1.6
Overall health rating	0.9	1.8	4.0	1.8	1.9	2.0	1.6	1.1	0.7	1.5	1.2	0.5	1.7	-0.2	0.2
Family relationship satisfaction	0.9	1.2	2.6	-1.6	-0.8	-0.9	-1.2	0.6	-1.5	-1.6	-0.3	-0.8	-1.5	-0.0	0.8
Arm predicted mass (left)	0.9	4.4	12.1	2.6	3.5	2.9	2.4	2.6	-0.6	2.5	-0.0	0.9	1.8	1.1	1.4
Depressed Affect (Nagel 2018)	0.8	1.7	6.7	1.5	0.9	1.5	1.4	1.0	1.1	1.2	2.6	0.2	1.4	0.1	0.1
Schizophrenia (2018)	0.8	1.7	8.2	-0.5	0.7	0.3	-0.5	-1.1	0.3	-0.8	1.1	0.3	0.9	-2.9	-2.7
Fasting Glucose	0.8	1.0	2.1	-0.8	-0.7	-1.0	-0.9	0.2	-1.5	-1.0	0.6	-1.4	-1.2	0.7	1.1
Trunk fat percentage	0.8	3.4	6.9	2.2	-0.1	1.6	2.1	-0.4	2.6	1.9	0.9	1.4	2.6	-2.0	-2.0
Trunk fat mass	0.8	3.5	7.8	2.7	0.9	2.2	2.5	0.3	2.0	2.3	0.7	1.3	2.8	-1.4	-1.3
Nervous feelings	0.8	1.4	6.3	1.2	1.4	1.4	1.1	0.1	1.1	0.8	2.5	0.3	1.3	-0.7	-0.5
Hip circumference	0.8	3.5	6.9	2.3	2.6	2.4	2.1	0.5	1.3	2.0	-0.0	1.5	2.6	-1.6	-1.1
Birth weight of first child	0.8	1.5	6.8	-1.3	1.2	0.0	-0.7	0.5	-0.3	-1.2	-2.6	1.7	-0.5	-1.2	-1.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.0	-0.6	-1.7	-1.0	-0.9	-1.7	1.5	-0.4	-0.3	-1.1	-0.6	0.1	-0.3
Migraine (self-reported)	0.8	1.0	6.0	-0.5	0.0	0.0	-0.5	1.8	-2.5	-0.0	-1.3	0.5	-0.6	0.3	0.5
Commuting to job workplace: Walk	0.8	0.8	2.3	-1.3	-0.9	-1.0	-1.0	-1.5	0.1	-1.2	-0.1	-0.0	-0.4	-0.9	-0.8
Medication for cholesterol	0.8	1.1	2.5	-1.5	0.1	-0.5	-1.6	0.5	-1.4	-1.5	0.1	-1.6	-1.4	0.4	0.1
Medication: Bendroflumethiazide	0.8	1.3	3.0	1.4	0.1	0.6	1.5	-0.3	1.7	1.5	-0.2	1.7	1.1	0.4	0.9
Ever smoked	0.8	1.4	3.2	-1.6	-1.8	-1.1	-1.5	-1.0	0.1	-1.6	0.3	-0.9	-0.9	-0.7	-1.1
Arm fat-free mass (left)	0.8	4.2	11.7	2.6	3.4	2.8	2.4	2.4	-0.4	2.4	0.3	0.8	2.0	0.8	1.2
Fractured/broken bones in last 5 years	0.8	1.1	4.0	-0.1	-1.5	-0.3	-0.0	1.5	0.8	0.2	-2.0	0.7	-0.6	1.0	1.3
Bipolar Disorder (2018)	0.7	1.1	4.2	0.6	1.4	1.1	1.0	0.9	1.1	0.7	-0.6	2.0	1.0	-0.9	-0.5
Bipolar Disorder or Schizophrenia	0.7	1.8	7.8	-0.0	1.5	0.9	0.2	-0.3	0.9	-0.2	0.5	1.5	1.4	-2.8	-2.4
Worry (Nagel 2018)	0.7	1.5	6.4	1.1	0.5	1.5	1.2	-0.3	2.2	0.9	2.5	0.6	1.0	-0.1	0.0
Alzheimer’s Disease (in mother)	0.7	0.8	2.8	-0.5	-1.7	-1.0	-0.5	-1.4	1.5	-0.5	-0.5	-0.4	-0.4	0.7	0.0
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	-0.4	-1.2	-0.5	-0.1	-1.0	1.7	-0.4	-1.7	-0.1	-0.7	1.3	1.0
Irritable Bowel Disease (IBD)	0.7	1.7	8.5	-1.5	-0.9	-1.0	-1.1	-0.4	-0.8	-0.7	-2.9	1.3	-1.8	-0.4	-0.5
Crohns Disease (2012)	0.7	1.1	3.7	-0.7	0.2	-0.4	-0.4	0.8	-0.7	-0.2	-1.4	0.2	-1.9	1.6	1.8
Lupus	0.7	1.0	2.7	-1.6	-0.7	-1.1	-1.4	-0.6	-0.9	-1.6	0.3	-0.6	-1.1	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.7	0.8	1.8	1.2	0.7	1.0	1.1	-1.3	0.0	1.2	0.8	0.4	1.2	-0.4	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.3	1.4	0.4	0.5	1.1	0.5	1.3	1.0	1.5	-1.1	0.7	1.2	0.2
Trunk fat-free mass	0.7	4.0	12.2	2.1	3.5	2.5	2.0	2.5	-1.4	2.0	0.0	0.4	1.3	1.5	1.8
Pulse rate	0.7	1.1	2.2	1.2	-0.2	1.2	1.4	0.0	1.0	1.2	0.9	1.5	1.4	-0.6	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.8	-0.9	-0.3	-0.7	-0.8	1.3	-1.7	-0.5	-1.5	0.3	-0.9	-0.4	-0.4
Arm fat mass (right)	0.7	3.0	6.2	2.5	1.3	2.1	2.3	0.4	1.9	2.1	0.7	1.0	2.5	-1.1	-1.0
Trunk predicted mass	0.7	4.2	13.0	2.2	3.6	2.6	2.1	2.5	-1.4	2.1	0.1	0.4	1.4	1.5	1.8
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.8	-0.4	-0.5	-0.3	-0.3	-1.3	0.7	-0.6	1.2	0.5	1.0	-1.7	-1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.8	0.1	-0.0	0.0	0.3	1.2	-1.9	0.6	-0.4	0.1	-1.2	1.9	1.6
Gout (self-reported)	0.7	0.9	1.9	0.8	1.4	1.4	1.2	1.4	0.8	0.9	0.2	1.1	0.9	-0.1	0.3
Arm fat-free mass (right)	0.7	3.6	10.6	2.2	3.2	2.4	2.0	2.6	-1.2	2.1	0.1	0.3	1.6	1.1	1.3
Medication: Ibuprofen	0.7	0.9	3.4	-1.0	-0.1	-1.0	-0.9	0.5	-1.6	-0.6	-1.8	0.2	-0.9	-0.4	-0.5
Whole body fat-free mass	0.7	4.0	10.6	2.4	3.2	2.6	2.3	2.5	-1.1	2.2	-0.0	0.4	1.5	1.4	1.6
Mineral and other dietary supplements	0.7	0.9	5.2	1.2	-0.4	0.4	0.9	-0.1	0.8	1.2	2.3	0.0	0.9	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.2	1.3	2.1	1.6	1.4	-0.9	1.5	0.9	0.4	0.5	1.5	-0.6	-0.9
Whole body water mass	0.7	4.0	11.1	2.4	3.3	2.6	2.3	2.5	-1.0	2.3	0.0	0.4	1.6	1.3	1.5
Medication: Atorvastatin	0.7	0.9	3.8	0.7	0.1	0.3	0.7	1.2	-0.7	0.8	1.1	-0.0	-0.1	1.4	1.9
Illnesses of father: High blood pressure	0.7	0.9	5.3	0.3	-0.2	0.4	0.1	-0.8	0.9	0.1	2.3	-0.3	0.8	-1.5	-1.0
Basal metabolic rate	0.7	3.8	9.8	2.5	3.1	2.7	2.4	2.2	-0.6	2.3	0.2	0.5	1.8	1.0	1.1
Diastolic blood pressure, automated reading	0.7	2.2	4.6	2.1	1.6	1.5	1.9	-0.9	1.0	1.8	1.2	1.0	2.0	-1.2	-0.9
Alzheimer’s Disease (in father)	0.6	0.6	2.6	-0.1	0.2	0.3	0.1	0.8	0.7	0.0	-1.6	0.2	-0.5	1.4	1.2
Bipolar Disorder (2011)	0.6	0.6	2.6	0.7	1.6	1.1	0.7	0.0	0.3	0.5	0.7	0.5	1.0	-0.6	-0.2
Rheumatoid Arthritis	0.6	0.8	4.1	0.1	-0.6	0.2	0.5	1.2	-0.5	0.1	-2.0	1.0	-0.8	0.8	0.9
Supplements: Zinc	0.6	0.7	2.6	-0.6	0.4	0.0	-0.2	1.5	-0.7	0.0	-1.3	1.6	-0.6	-0.0	0.6
Leg fat-free mass (left)	0.6	3.1	5.9	2.4	2.4	2.3	2.1	2.1	-0.8	2.2	0.0	0.1	1.4	1.3	1.3
Supplements: Glucosamine	0.6	0.7	2.6	0.5	1.6	0.9	0.7	0.5	-0.7	0.4	-1.1	1.1	0.6	-1.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.4	1.0	0.1	0.6	0.9	0.5	1.6	0.7	0.9	0.2	0.7	0.8	0.9
Leg predicted mass (left)	0.6	3.1	5.9	2.4	2.4	2.4	2.2	2.1	-0.8	2.2	0.1	0.1	1.4	1.3	1.3
Medication: Simvastatin	0.6	0.9	2.4	1.3	1.6	1.0	1.1	0.3	0.1	1.1	1.1	0.0	1.2	-0.2	0.2
Alcohol intake versus 10 years previously	0.6	0.9	3.1	-0.7	-0.3	-1.2	-0.9	-0.4	-1.3	-1.1	1.2	-1.8	-0.6	0.6	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	8.3	1.7	2.9	2.1	1.8	0.4	-0.1	1.4	1.0	0.2	1.4	0.2	-0.4
Prospective memory result	0.6	0.7	1.8	0.7	-0.1	0.5	0.8	-0.3	0.7	0.6	0.8	1.3	1.3	-1.3	-0.8
Pulse wave reflection index	0.6	0.7	2.3	-0.8	1.5	-0.3	-0.7	-0.1	-0.3	-1.1	-1.1	-0.9	-0.2	-1.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.8	-0.2	-0.4	-0.3	-0.3	-1.6	1.2	-0.4	0.5	0.3	0.4	-1.4	-1.7
Illnesses of father: Heart disease	0.6	0.8	2.3	-0.8	0.4	-1.3	-1.0	-1.5	0.0	-0.8	1.2	-1.2	-0.6	-0.1	-0.7
Loneliness, isolation	0.6	0.8	3.8	0.6	-0.2	0.3	0.4	1.6	-0.2	0.3	0.1	-1.0	-0.5	1.9	1.0
Breast cancer (self-reported)	0.6	0.7	3.0	-0.0	0.6	0.1	0.1	-0.9	1.7	-0.3	0.5	0.2	0.9	-1.4	-1.1
Leg predicted mass (right)	0.6	3.0	5.9	2.3	2.4	2.3	2.1	2.1	-0.9	2.1	-0.2	0.1	1.3	1.2	1.3
Wears glasses or contact lenses	0.6	0.7	2.7	-1.1	-0.7	-0.4	-0.6	-1.6	0.9	-1.3	-0.4	0.3	-0.7	0.2	-0.1
Medication: Paracetamol	0.6	1.0	3.8	-0.3	-0.0	-0.7	-0.4	-1.7	1.1	-0.8	-0.7	-0.0	0.0	-1.9	-1.4
Risk taking	0.6	0.9	1.8	1.0	0.8	0.9	0.9	1.2	-1.3	1.3	-0.5	1.0	0.2	1.0	0.9
Cholesterol lowering medication	0.6	0.9	2.0	1.2	1.2	0.9	1.1	-0.4	0.8	1.0	1.1	0.2	1.4	-0.4	-0.1
Alcohol drinker status: Previous	0.6	0.7	2.2	0.7	0.5	1.0	0.9	-0.2	1.2	0.7	0.4	1.5	0.7	-0.5	0.3
Depression (Nagel 2018)	0.5	0.8	3.9	0.5	0.6	1.1	0.5	0.0	2.0	0.8	1.3	0.5	0.8	0.1	-0.0
Breast Cancer	0.5	1.2	2.9	-0.8	-0.6	-0.5	-0.4	1.2	-1.7	-0.6	-1.2	0.8	-1.6	0.9	1.6
LDL Cholesterol	0.5	0.8	2.0	-1.3	-0.1	-0.9	-1.3	-0.3	-0.2	-1.1	-1.4	-0.6	-1.2	0.1	-0.1
Respiratory disease	0.5	1.2	4.4	-0.5	-2.0	-0.7	-0.6	-2.1	1.6	-0.4	-0.1	-0.6	-0.9	0.8	0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.5	0.9	0.3	0.8	1.0	0.6	-0.2	0.7	-1.6	1.0	0.4	-0.1	0.0
Systolic blood pressure, automated reading	0.5	1.3	2.5	1.3	0.9	0.8	1.2	-1.2	1.2	0.9	1.3	0.7	1.6	-1.6	-0.8
Hand grip strength (right)	0.5	1.4	6.1	0.4	0.5	0.0	0.2	0.5	-1.7	0.6	-0.1	-1.1	-0.9	2.5	2.1
Fed-up feelings	0.5	0.9	5.1	0.1	-0.0	0.2	0.1	-0.4	1.4	-0.2	2.3	-0.1	0.6	-1.0	-1.3
Qualifications: CSEs or equivalent	0.5	0.7	1.4	-1.1	-0.2	-0.9	-1.2	0.4	-1.0	-1.1	0.4	-0.7	-0.7	-0.3	-0.8
Multivitamins +/- minerals	0.5	0.6	1.9	-1.0	0.3	-0.3	-0.7	-0.8	-0.5	-0.9	-0.8	0.7	-0.3	-1.4	-1.0
Hearing difficulty/problems with background noise	0.5	0.8	3.4	-0.7	-0.2	-0.0	-0.5	-1.4	1.9	-0.6	-0.0	0.3	-0.1	-1.3	-1.0
Had other major operations	0.5	0.6	1.8	0.4	0.9	0.8	0.6	0.8	0.6	0.2	-1.1	0.6	-0.3	0.7	1.3
Worrier / anxious feelings	0.5	0.9	5.2	0.7	1.3	0.9	0.7	0.2	1.3	0.5	2.3	-0.0	0.6	-0.2	-0.2
Medication: Cholesterol lowering	0.5	0.8	2.6	-0.4	-0.5	-0.8	-0.7	0.7	-1.6	-0.3	0.6	-1.2	-0.7	0.6	1.3
Pulse wave Arterial Stiffness index	0.5	0.6	4.7	0.3	2.2	0.5	0.3	0.5	-0.4	0.3	0.0	-0.2	0.7	-0.8	-0.8
Medication: Paracetamol	0.5	0.8	3.9	-0.2	0.2	-0.6	-0.5	-1.1	1.1	-0.7	-0.8	-0.4	0.2	-2.0	-1.2
Forced vital capacity (FVC), Best measure	0.5	1.8	5.2	1.8	2.0	2.3	2.0	0.3	0.6	1.4	0.6	0.2	1.3	0.6	0.1
Comparative body size at age 10	0.5	1.3	2.9	1.1	0.8	1.2	1.3	1.7	-0.5	1.3	-0.8	0.8	0.7	1.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.4	-0.5	-0.0	-0.4	-0.3	0.8	-0.9	-0.6	0.5	-0.4	-0.9	1.4	1.5
Medication for pain relief, constipation, heartburn	0.5	0.9	1.8	1.1	0.0	1.3	1.1	-0.1	1.1	1.4	1.1	0.5	0.9	1.1	0.5
Chest pain or discomfort	0.5	0.7	5.1	0.5	0.0	0.1	0.4	-0.5	2.2	0.5	0.4	0.5	0.9	-0.6	-0.9
Age at last live birth	0.5	0.7	2.9	-0.5	-0.7	-0.6	-0.8	-1.4	-0.2	-0.6	0.9	-1.7	-0.3	0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	4.3	-0.8	0.5	-0.7	-0.5	0.1	-2.1	-0.8	-0.3	0.3	-0.4	-0.7	-0.5
Medication: Aspirin	0.5	0.7	1.8	-1.4	-0.8	-1.0	-1.2	-0.0	-0.4	-1.2	-0.9	-0.1	-0.9	-0.6	-0.0
Knee pain experienced in last month	0.5	0.8	3.1	0.4	0.4	1.1	0.6	0.8	0.9	0.6	-1.2	1.8	0.6	-0.6	-0.6
Leg fat-free mass (right)	0.5	2.9	5.9	2.3	2.4	2.3	2.1	2.1	-0.9	2.1	-0.3	0.1	1.3	1.2	1.2
Medication: Aspirin	0.5	0.7	1.8	-1.3	-0.5	-1.0	-1.1	-0.1	-0.2	-1.2	-0.9	-0.1	-0.9	-0.5	0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	2.3	0.6	0.1	1.0	0.9	1.0	-0.5	0.7	-0.7	1.5	0.6	0.3	0.5
Medication: Blood pressure	0.5	0.9	3.3	0.3	-0.5	-0.2	0.5	-0.8	1.8	0.3	-0.6	1.4	0.8	-1.5	-1.0
Irritability	0.5	0.9	3.0	0.5	0.0	0.5	0.9	-1.2	1.4	0.1	0.9	1.7	0.6	-0.7	-1.0
Heart disease (siblings)	0.5	0.6	2.0	1.2	0.4	0.7	1.1	-0.0	0.5	1.0	1.4	-0.0	1.0	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.5	-0.3	-0.4	-0.3	0.1	1.1	-0.3	0.0	-1.6	0.9	-0.3	0.7	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.2	0.6	0.3	0.7	0.3	-0.2	1.4	0.7	0.3	0.2	1.2	-1.8	-1.2
Medication: Co-codamol	0.4	0.5	3.5	0.2	-0.1	0.8	0.6	0.3	0.5	0.6	-0.6	1.9	0.2	0.2	0.7
Townsend deprivation index at recruitment	0.4	0.6	2.1	1.0	1.4	0.9	0.9	0.2	0.9	0.6	0.2	0.2	0.7	0.2	-0.1
Average weekly fortified wine intake	0.4	0.5	2.2	0.2	0.0	0.5	0.2	1.5	-0.4	0.7	-0.6	0.4	-0.2	0.6	1.2
Relative age voice broke	0.4	0.7	2.2	-0.4	0.2	-0.2	-0.4	-1.0	0.3	-0.4	1.4	-0.3	0.4	-1.4	-1.5
Taking other prescription medications	0.4	0.6	3.6	0.5	-0.0	0.5	0.6	-0.5	1.9	0.1	-0.6	0.4	-0.1	0.6	1.2
Allergy	0.4	0.9	3.6	-0.2	1.9	0.4	-0.3	1.3	-1.5	-0.2	-0.8	0.3	0.6	-1.3	-0.8
Impedance of arm (right)	0.4	1.7	6.7	-0.6	-2.6	-0.7	-0.6	-2.1	2.0	-0.7	1.1	-0.5	-0.3	-0.8	-1.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.8	-0.4	-1.3	-0.8	-1.2	-0.3	-1.1	0.8	-0.5	-0.8	0.1	0.4
Tense / ‘highly strung’	0.4	0.6	4.2	0.6	1.0	0.7	0.6	0.4	-0.2	0.1	2.0	0.2	0.8	-0.3	-0.4
Peak expiratory flow (PEF)	0.4	0.9	2.8	0.9	1.7	1.0	0.9	1.1	-1.3	0.9	-0.4	-0.2	0.0	1.0	0.5
Qualifications: College or University degree	0.4	1.1	3.3	0.7	-0.9	0.2	0.8	0.8	-1.2	0.9	-1.4	0.3	-0.3	1.8	1.8
Emphysema/chronic bronchitis	0.4	0.4	2.3	-0.2	-0.8	0.3	0.1	-0.2	1.4	-0.0	0.3	1.5	0.0	-0.2	0.3
Number of full sisters	0.4	0.5	1.6	1.0	-0.3	0.8	0.9	-0.3	1.3	0.8	0.8	0.2	0.9	-0.1	0.3
Hypertension (Self-reported)	0.4	1.0	3.1	1.0	0.5	0.9	0.9	0.2	0.6	1.1	0.2	0.8	1.6	-1.8	-0.9
Smoking status: Previous	0.4	0.6	1.5	0.8	-0.8	0.2	0.6	-0.2	0.8	0.5	1.2	0.5	1.1	-0.9	-0.7
Diabetes diagnosed by doctor	0.4	0.7	2.7	-0.0	-0.1	0.5	-0.1	-1.1	1.4	0.1	0.1	0.3	0.9	-1.6	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	0.9	0.0	0.7	0.9	-0.6	-0.3	0.3	1.0	0.4	0.9	-0.8	-0.5
Guilty feelings	0.4	0.7	2.7	-0.9	-0.1	-0.2	-0.5	0.1	0.4	-1.0	-0.8	-0.5	-1.1	1.6	1.1
Hearing aid user	0.4	0.4	1.0	0.8	0.6	0.7	0.6	0.3	0.5	1.0	-0.2	0.4	0.6	0.7	0.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.8	-0.4	0.4	0.8	-0.7	0.6	0.7	1.1	-0.2	0.5	1.2	0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	0.4	0.1	0.8	0.4	1.1	-0.1	0.8	-0.8	1.1	-0.0	0.3	0.9
High cholesterol (Self-reported)	0.4	0.7	3.0	0.9	1.0	0.5	0.8	0.6	-0.7	0.7	1.7	-0.4	1.0	-0.3	-0.2
Unable to work because of sickness or disability	0.4	0.5	1.4	1.0	0.9	0.9	0.8	-0.2	1.2	1.0	0.3	0.4	0.6	0.3	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.8	-0.1	1.3	0.4	-0.0	-0.7	0.4	-0.4	0.3	0.5	0.5	-1.3	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.6	0.8	0.4	1.2	1.0	0.9	0.0	0.8	-0.1	0.3	0.1	0.7	1.3
Crohns Disease (2017)	0.3	0.7	2.6	0.1	0.7	0.3	0.2	1.0	-0.5	0.7	-1.6	1.2	-0.8	0.6	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	2.4	0.7	0.2	-0.1	0.3	0.5	0.2	0.6	0.6	-1.6	0.6	0.3	-0.6
HbA1C	0.3	0.4	2.2	-0.4	0.5	0.4	-0.1	-0.1	0.8	-0.1	-1.5	0.7	-0.3	0.5	0.0
Heel T-Score	0.3	2.7	11.1	-0.2	-1.6	-0.3	-0.0	3.3	-2.1	0.1	-2.1	0.2	-1.6	1.6	2.2
Waist Hip Ratio (WHR)	0.3	1.5	3.2	1.3	-1.6	0.2	1.4	1.8	-1.2	1.5	0.6	0.4	0.3	1.7	1.4
Allergy or Eczema	0.3	0.8	4.6	-0.2	-2.1	-0.8	-0.0	-0.4	0.1	-0.4	0.6	-0.8	-0.8	1.4	0.7
Chronotype (morning person)	0.3	0.8	3.0	0.5	0.8	0.4	0.5	1.4	-1.7	0.8	-0.7	0.3	0.1	0.9	1.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	0.7	0.9	1.0	0.7	0.2	-0.3	0.6	-0.2	0.5	0.7	0.1	-0.4
Vitamin and mineral supplements	0.3	0.4	1.5	0.0	-0.8	-0.3	-0.1	0.7	-0.2	0.0	0.5	-0.6	-0.6	1.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	-0.0	-0.1	-0.9	-0.1	-0.9	-0.1	-0.0	-0.1	-0.5	-0.7	1.0	0.5
High blood pressure	0.3	0.8	3.1	0.8	0.4	0.6	0.7	0.1	0.1	0.8	0.3	0.6	1.5	-1.8	-1.0
Stomach or abdominal pain in last month	0.3	0.3	0.9	0.9	0.7	0.6	0.7	0.0	-0.0	0.7	0.7	-0.2	0.8	-0.5	0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	1.0	0.0	0.4	0.7	0.5	0.1	1.0	0.1	0.1	0.4	0.4	0.9
Impedance of leg (left)	0.3	1.2	2.9	-0.6	-1.4	-0.4	-0.5	-1.5	1.6	-0.5	1.0	0.6	0.2	-1.5	-1.7
Past tobacco smoking	0.3	0.6	2.0	0.4	1.4	0.6	0.6	0.7	-0.8	0.6	-0.9	0.5	-0.2	1.1	1.0
Forced vital capacity (FVC)	0.3	1.1	4.9	1.2	2.2	1.6	1.3	0.2	-0.4	0.9	0.8	-0.2	0.8	0.3	-0.0
Happiness	0.3	0.4	1.3	-0.8	0.1	0.2	-0.2	0.7	-1.1	-0.7	-0.7	1.0	-0.8	-0.1	0.3
Impedance of arm (left)	0.3	1.4	6.7	-0.7	-2.6	-1.0	-0.8	-1.6	0.7	-0.8	1.3	-1.2	-0.6	-0.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.5	-0.1	-0.7	-0.6	0.8	-0.8	-0.6	0.9	-1.0	-0.3	0.1	-0.2
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.7	0.4	1.0	0.8	0.6	-0.1	0.7	-0.1	0.0	0.1	0.7	1.1
High blood pressure (siblings)	0.3	0.5	1.7	0.0	-0.5	-0.3	-0.2	-1.0	0.6	-0.0	0.8	-0.4	0.7	-1.0	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	1.2	-0.4	-1.1	-0.3	-0.3	0.7	0.7	-0.5	-0.9	-0.2	-0.7	0.9	0.8
Neck or shoulder pain in last month	0.3	0.4	1.3	0.7	0.9	0.4	0.6	0.5	1.2	0.4	0.0	0.4	0.6	-0.4	-0.2
Heart disease (mother)	0.3	0.4	1.1	0.7	0.6	0.6	0.5	0.5	-0.5	1.1	-0.0	0.6	0.8	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.4	0.9	0.7	0.9	0.9	0.8	-0.6	0.8	0.6	-0.5	0.1	1.2	1.1
Mood swings	0.3	0.6	4.0	0.2	0.7	0.7	0.4	0.2	0.6	0.0	2.0	0.3	0.7	-0.6	-0.5
Eye problems/disorders: Cataract	0.3	0.3	1.6	0.3	0.6	0.3	0.3	0.3	0.3	0.6	-0.3	1.3	0.1	-0.2	-0.8
Medication: Gliclazide	0.3	0.3	1.8	-0.1	-0.3	-0.5	-0.3	-0.2	-1.3	-0.1	-0.6	-0.6	-0.3	-0.5	0.1
Smoking status: Current	0.3	0.4	1.0	-1.0	-0.0	-0.4	-1.0	0.1	-0.5	-0.9	0.2	-0.7	-0.9	0.6	0.1
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	0.9	-0.3	0.6	1.0	0.3	0.9	0.8	0.6	0.5	0.4	0.8	1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	3.0	-0.4	0.5	0.2	-0.1	0.4	0.6	-0.5	-1.7	0.1	-0.4	0.3	0.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	2.0	-0.3	-0.1	-0.8	-0.3	0.4	-0.8	-0.1	1.4	-0.1	0.1	-0.4	-0.3
Age started oral contraceptive pill	0.3	0.4	1.6	-0.5	-0.2	0.0	-0.5	-1.0	-0.3	-0.7	-1.3	-0.5	-0.3	-0.6	-0.7
Impedance of whole body	0.3	1.5	6.0	-0.7	-2.5	-0.8	-0.7	-1.7	1.4	-0.7	1.3	-0.4	-0.2	-1.0	-1.5
Ovarian Cancer	0.2	0.3	1.4	0.6	0.3	0.4	0.5	-0.6	1.2	0.4	-0.1	0.6	0.2	-0.2	0.2
HDL Cholesterol	0.2	0.3	2.3	0.1	0.5	0.5	0.4	-0.2	0.4	0.0	0.5	1.5	0.4	-0.6	-0.2
Blood Red Count	0.2	2.0	6.0	2.1	-0.3	1.0	1.8	-0.5	2.4	1.9	0.8	1.2	1.7	-0.6	-0.1
Systolic Blood Pressure	0.2	0.8	3.0	0.0	-0.2	-0.3	-0.1	-1.7	1.0	-0.2	0.8	-0.1	0.4	-1.7	-1.2
Smoking Status	0.2	0.5	1.4	-0.3	0.7	0.1	-0.3	-0.9	1.1	-0.5	1.0	0.0	0.5	-0.9	-1.2
Hand grip strength (left)	0.2	0.5	1.7	0.9	1.3	0.5	0.6	0.0	-1.0	1.0	-0.2	-0.1	-0.1	0.7	0.6
Relative age of first facial hair	0.2	0.4	1.4	-0.4	-1.2	-0.5	-0.6	-0.9	-0.3	-0.3	-0.2	-0.7	-0.7	0.7	0.3
Medication: Metformin	0.2	0.2	1.4	0.1	0.4	0.3	0.0	-0.3	0.1	0.2	0.3	0.0	0.4	-1.2	-0.7
Diabetes (mother)	0.2	0.2	0.8	0.0	0.5	-0.3	-0.2	-0.5	0.4	-0.1	-0.4	0.0	0.2	-0.8	-0.9
Impedance of leg (right)	0.2	1.1	2.7	-0.7	-1.6	-0.5	-0.5	-1.3	1.6	-0.6	1.3	0.6	-0.0	-1.1	-1.3
Current tobacco smoking	0.2	0.3	0.9	-0.8	0.1	-0.2	-0.7	0.4	-0.6	-0.6	-0.1	-0.4	-0.9	0.8	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.0	-0.2	-1.4	-0.5	0.0	-1.1	0.5	-0.3	1.0	-0.7	-0.6	0.9	0.4
Number of incorrect matches in round	0.2	0.4	1.1	-0.6	0.8	-0.2	-0.5	-0.6	-0.5	-0.6	0.3	0.1	-0.0	-1.0	-0.9
Had menopause	0.2	0.2	1.2	-0.0	-0.6	-0.1	-0.1	-0.4	-1.1	-0.3	-0.7	-0.2	0.1	-0.1	-0.6
Medication: Ramipril	0.2	0.2	1.1	0.4	0.3	0.3	0.4	1.1	-0.6	0.6	-0.1	0.2	0.5	0.3	0.3
Depression (self-reported)	0.2	0.3	1.0	-0.2	-0.1	0.0	0.0	0.7	-0.0	-0.2	0.3	-0.2	-0.7	1.0	1.0
Standing height	0.2	2.2	5.5	1.0	1.7	1.5	0.9	2.0	-2.4	1.1	0.5	-0.9	0.0	2.0	1.9
Breastfed as a baby	0.2	0.3	1.5	0.1	-0.7	0.2	0.3	0.2	-0.3	0.1	0.4	0.4	-0.4	0.9	1.2
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	-0.8	-0.9	-0.7	-0.7	-0.1	0.5	-0.7	-0.6	-0.5	-1.0	0.5	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.4	0.3	0.5	0.5	0.4	0.1	1.0	0.2	-1.2	0.6	-0.1	0.4	0.0
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.2	-0.3	-0.7	-0.5	-0.4	0.1	-1.1	-0.3	-0.4	0.5	-0.4	-0.4	-0.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.9	0.4	-0.4	0.4	0.4	0.2	1.4	0.5	-0.7	0.8	0.5	-0.4	-0.6
Eye problems/disorders: None of the above	0.2	0.3	0.8	-0.7	0.5	0.1	-0.4	0.6	-0.4	-0.6	-0.9	0.1	-0.5	-0.3	0.5
Medication: Blood pressure	0.2	0.3	0.9	-0.3	-0.8	-0.6	-0.4	0.5	-1.0	-0.2	0.3	-0.4	-0.4	0.3	0.5
Alcohol intake frequency.	0.2	0.4	1.1	0.8	0.4	0.3	0.8	-0.1	0.8	0.6	1.1	0.4	0.9	0.0	0.4
Leg pain on walking	0.2	0.2	0.7	0.4	0.5	0.4	0.3	0.9	-0.2	0.1	0.3	-0.6	0.3	0.6	0.5
Ever had bowel cancer screening	0.2	0.3	1.4	0.4	0.4	0.6	0.6	-0.4	-0.1	0.1	1.2	0.4	0.3	-0.7	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.4	-0.0	0.3	0.4	0.0	-0.7	0.5	0.8	0.4	0.3	0.7	0.2
Number of operations (self-reported)	0.2	0.3	0.8	-0.7	0.5	-0.7	-0.6	-0.5	0.0	-0.9	-0.1	-0.6	-0.8	0.3	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.1	-0.8	-0.3	-0.4	-0.7	-0.3	0.2	-0.8	-0.8	-0.3	-1.4	1.4	0.6
Reaction Time	0.1	0.2	0.8	-0.6	0.3	-0.3	-0.7	0.2	0.0	-0.6	0.9	-0.6	-0.2	-0.2	-0.3
Prostate Cancer	0.1	0.2	0.9	0.2	-0.0	-0.0	0.2	-0.7	1.0	0.1	0.7	0.3	0.3	0.3	-0.0
Triglycerides	0.1	0.2	0.9	0.2	0.2	-0.1	-0.1	0.6	-0.5	0.5	0.4	-0.9	0.1	0.7	0.2
Height	0.1	2.1	7.1	-0.0	-0.2	-0.2	-0.1	0.3	-2.2	-0.2	1.0	-2.2	-1.5	2.7	2.3
Cardiovascular Disease	0.1	0.5	1.4	1.0	0.7	0.3	0.7	0.6	-0.2	0.8	0.7	-0.6	1.2	-0.7	-0.3
Lung FVC	0.1	0.4	1.2	0.4	1.1	0.3	0.4	-0.1	-0.7	0.1	1.0	-1.1	0.6	0.5	-0.2
Tanning	0.1	1.4	5.5	1.3	2.4	1.5	1.4	-0.1	0.5	0.8	0.9	1.2	1.3	-0.5	-0.7
Number of treatments/medications taken	0.1	0.3	0.9	-0.1	-0.6	-0.3	0.1	-0.0	0.7	-0.2	-1.0	0.5	-0.3	-0.3	0.9
Average weekly spirits intake	0.1	0.1	0.6	-0.0	-0.1	0.2	-0.0	-0.2	0.3	0.3	-0.4	0.8	0.4	-0.3	-0.0
Sensitivity / hurt feelings	0.1	0.2	0.9	0.0	0.3	0.4	0.1	0.1	1.0	-0.2	0.7	-0.1	0.1	-0.7	-0.5
Sitting height	0.1	0.9	2.7	0.0	0.9	0.4	-0.2	1.6	-1.1	0.2	-0.5	-1.2	-0.6	1.5	1.0
High blood pressure (mother)	0.1	0.1	0.5	-0.3	-0.2	-0.2	-0.2	-0.2	0.6	-0.0	0.3	0.7	-0.1	-0.4	0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.6	0.1	-0.2	0.6	0.1	0.1	0.4	0.0	-0.0	0.2	0.1	-0.8	-0.6
Illnesses of mother	0.1	0.2	0.4	-0.5	-0.2	-0.3	-0.3	-0.6	0.6	-0.6	0.2	-0.3	-0.3	0.0	-0.4
Birth weight	0.1	0.1	0.6	-0.2	0.8	0.4	0.1	-0.3	0.0	-0.5	0.2	-0.1	0.0	0.4	0.0
Medication: Omeprazole	0.1	0.2	0.7	-0.1	0.7	0.3	-0.0	-0.1	-0.3	-0.2	0.4	0.3	0.2	-0.8	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.5	-0.2	-0.3	-0.0	-0.2	-0.0	0.0	0.0	0.7	0.5	-0.5	0.5	0.2
Mean time to correctly identify matches	0.1	0.2	0.7	-0.6	-0.0	-0.2	-0.5	-0.3	0.6	-0.8	0.8	-0.3	-0.2	-0.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.3	0.1	-0.5	0.3	0.4	0.1	0.1	0.3	-0.3	0.1	-0.1	-0.3
Comparative height size at age 10	0.1	0.6	3.1	0.7	1.8	1.1	0.6	0.2	-0.1	0.9	0.3	0.3	1.0	-0.2	-0.5
Hair Pigment	0.0	1.4	3.2	1.5	1.0	1.1	1.3	1.6	0.0	1.8	1.2	0.1	1.6	0.2	0.8
Had major operations	0.0	0.1	0.1	-0.3	0.4	-0.0	-0.3	0.1	-0.1	-0.1	-0.1	0.3	-0.0	0.4	0.3

Hub : Genes

JAK1

Models

Trait associations