Hub : Genes

ZC3HAV1L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1629	0.0407	4.1e-06	0.124	NA	0.078	NA	0.019	4.8e-09	NA	3.6e-06	NA	0.017
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0262	0.0155	2.8e-03	0.030	0.007	0.017	NA	-0.002	2.1e-04	0.045	4.2e-03	NA	0.930
3	TCGA	Lung Squamous Cell Carcinoma	0.0189	0.0113	7.5e-03	0.012	0.005	-0.002	NA	0.000	1.4e-02	0.079	9.7e-01	NA	0.290

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.3	2.1	2.5	1.4	-1.6	-1.2
Bipolar Disorder or Schizophrenia	1.9	4.7	5.7	2.0	-2.4	-2.1
Depressed Affect (Nagel 2018)	0.8	1.8	2.4	-1.2	1.2	1.6
Depression (Nagel 2018)	1.1	1.7	1.9	-1.3	1.2	1.4
Intelligence (Savage-Jansen 2018)	1.3	4.1	5.2	2.3	-1.9	-1.9
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.4	0.4	0.5
Schizophrenia (2018)	1.3	2.6	3.2	1.4	-1.8	-1.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.0	0.2	-1.1
Worry (Nagel 2018)	0.1	0.2	0.2	-0.3	0.5	0.4
Alzheimer’s Disease (in mother)	1.0	1.2	2.0	-0.8	0.9	1.4
Alzheimer’s Disease (in father)	0.0	0.0	0.0	0.2	-0.2	-0.2
Alzheimer’s Disease (including proxy)	1.4	2.0	2.5	-1.2	1.5	1.6
Crohns Disease (2017)	1.0	2.2	3.0	1.7	-1.6	-1.0
Irritable Bowel Disease (IBD)	0.2	0.5	0.7	0.8	-0.8	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.3	0.3	0.7
Major Depression (MDD)	0.5	0.6	0.8	0.6	-0.8	-0.9
Reaction Time	0.8	1.5	1.7	-1.3	1.1	1.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.4	1.2	-0.8	-0.9
Breast Cancer	0.8	1.9	2.7	-1.7	1.5	0.9
Ovarian Cancer	0.9	1.2	1.5	1.1	-1.2	-0.8
Prostate Cancer	0.0	0.0	0.0	-0.2	0.2	0.1
Age at First Birth	0.5	0.7	0.9	0.9	-0.8	-0.8
Bipolar Disorder (2011)	7.3	7.0	7.7	2.7	-2.8	-2.4
Body Mass Index (BMI) (2010)	1.4	2.0	2.4	-1.5	1.6	1.1
Coronary Artery Disease (CAD)	1.1	1.3	1.6	1.1	-1.2	-1.1
Crohns Disease (2012)	2.9	4.6	5.9	2.4	-2.3	-1.7
Mean Putamen Volume	0.7	0.8	1.3	-1.1	0.6	0.7
Fasting Glucose	1.6	1.9	2.1	-1.4	1.4	1.3
HbA1C	1.2	1.3	2.3	-1.2	1.5	0.4
HDL Cholesterol	0.1	0.2	0.5	-0.3	0.2	0.7
LDL Cholesterol	0.5	0.7	1.1	0.8	-0.7	-1.1
Lupus	6.7	10.2	10.3	-3.2	3.2	3.2
Neuroticism (2016)	0.2	0.2	0.5	0.2	-0.5	-0.7
Primary Biliary Cirrhosis	11.0	15.6	17.3	-3.6	4.0	4.2
Rheumatoid Arthritis	0.0	0.0	0.1	0.3	-0.1	0.0
Schizophrenia (2014)	0.7	1.6	2.2	0.9	-1.4	-1.5
Triglycerides	2.1	3.4	4.2	1.6	-1.8	-2.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.6	0.8	-0.4	-0.7
Ulcerative Colitis	0.2	0.2	0.4	0.4	-0.7	-0.3
Blood Eosinophil Count	0.6	5.0	6.6	-2.6	2.2	1.8
Blood Platelet Count	2.6	29.6	34.6	-5.9	5.2	5.2
Blood Red Count	1.0	9.6	13.3	-2.7	2.8	3.6
Blood White Count	3.8	28.2	32.6	-5.7	5.5	4.6
Heel T-Score	0.4	3.6	5.2	-1.8	1.5	2.3
BMI	0.1	0.6	0.7	0.6	-0.8	-0.8
Height	0.1	2.0	2.9	-1.4	1.7	1.2
Waist Hip Ratio (WHR)	0.5	2.2	2.8	1.3	-1.7	-1.5
Systolic Blood Pressure	0.3	1.5	2.2	1.5	-1.1	-1.1
Smoking Status	0.1	0.1	0.2	-0.3	0.2	-0.5
Allergy or Eczema	0.0	0.1	0.2	-0.1	-0.2	-0.5
Cardiovascular Disease	1.2	4.0	4.7	2.1	-2.2	-1.7
Hypothyroidism (self reported)	3.5	8.1	8.8	-2.7	3.0	2.9
Respiratory disease	0.1	0.2	0.4	0.4	0.0	-0.6
Type 2 Diabetes (T2D) (2018)	0.8	1.6	1.9	-1.4	1.1	1.2
Lung FEV1/FVC ratio	0.5	2.3	2.8	-1.7	1.5	1.4
Lung FVC	0.1	0.5	0.8	0.6	-0.6	-0.9
Neuroticism	0.2	0.4	0.6	0.7	-0.8	-0.5
Chronotype (morning person)	0.2	0.5	0.9	1.0	-0.6	-0.4
Hair Pigment	0.0	1.0	1.9	-0.8	0.7	1.4
Tanning	0.0	0.0	0.0	0.0	-0.2	-0.1
Hand grip strength (left)	1.6	4.2	5.2	2.1	-1.8	-2.3
Number of treatments/medications taken	0.1	0.2	0.6	-0.3	0.1	0.8
Average weekly spirits intake	3.5	4.3	6.2	-2.1	2.5	1.6
Sensitivity / hurt feelings	0.6	1.0	1.1	0.9	-1.1	-1.0
Frequency of depressed mood in last 2 weeks	0.8	1.2	1.8	-1.1	0.7	1.3
Hearing difficulty/problems: Yes	2.2	3.4	3.8	1.8	-2.0	-1.7
Relative age of first facial hair	0.1	0.1	0.3	-0.1	0.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.0	0.2	0.6
Ever used hormone-replacement therapy (HRT)	2.2	2.8	3.0	-1.7	1.6	1.7
Ever had hysterectomy (womb removed)	1.5	1.7	1.8	1.3	-1.3	-1.3
Systolic blood pressure, automated reading	1.4	4.1	5.3	2.3	-1.9	-1.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.2	0.4	0.9
Angina	0.9	1.2	1.4	1.2	-1.0	-1.1
Medication for hormone replacement therapy	0.6	0.7	0.9	-0.8	0.9	0.7
Vitamin and mineral supplements	0.2	0.2	0.4	-0.4	0.6	0.4
Supplements: Zinc	0.6	0.7	0.8	0.9	-0.9	-0.7
Medication: Co-codamol	0.4	0.5	0.7	0.8	-0.5	-0.8
Medication: Metformin	4.9	6.9	7.9	-2.6	2.4	2.8
Diabetes (father)	0.2	0.2	0.3	0.4	-0.4	-0.5
Diabetes (mother)	0.6	0.7	1.1	0.6	-1.0	-0.8
Severe depression (siblings)	0.1	0.2	0.4	0.0	-0.2	-0.7
Pack years adult smoking proportion	1.0	1.5	1.9	1.4	-1.1	-1.2
Impedance of leg (right)	0.0	0.1	0.1	0.2	-0.2	-0.3
Leg fat-free mass (left)	0.1	0.5	0.7	-0.9	0.8	0.5
Trunk fat percentage	0.5	1.8	3.1	1.2	-1.0	-1.8
Hand grip strength (right)	0.4	1.0	1.2	1.0	-0.9	-1.1
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.5	0.4	0.1
Current tobacco smoking	2.9	4.8	6.0	-2.4	2.2	1.9
Average weekly fortified wine intake	0.1	0.1	0.3	0.1	0.5	-0.2
Maternal smoking around birth	0.1	0.1	0.1	0.3	-0.1	-0.4
Fed-up feelings	1.2	2.1	2.6	-1.5	1.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.8	4.6	-2.1	1.8	1.9
Relative age voice broke	0.9	1.4	2.6	0.8	-0.9	-1.6
Taking other prescription medications	0.6	0.9	1.4	-0.9	0.6	1.2
Age when periods started (menarche)	0.0	0.1	0.2	-0.0	0.1	-0.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.9	1.2	-1.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	2.8	-1.7	1.2	1.5
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.1	-0.1	-0.0
Qualifications: CSEs or equivalent	0.0	0.0	0.0	-0.2	0.1	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.0	0.2	-0.7
High blood pressure	2.5	6.9	7.3	2.7	-2.7	-2.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.3	-1.1	0.9	0.8
Multivitamins +/- minerals	1.4	1.8	2.5	1.2	-1.6	-1.2
Stomach or abdominal pain in last month	0.5	0.6	0.9	-0.7	0.6	0.9
Supplements: Glucosamine	0.3	0.3	0.4	0.6	-0.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.0	-0.9	1.0	0.9
Medication: Atenolol	0.7	0.8	1.6	-0.6	0.7	1.2
Medication: Levothyroxine sodium	2.3	3.9	4.7	-1.7	2.0	2.2
Sitting height	0.0	0.0	0.1	0.0	-0.1	-0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	-0.4	0.5	0.5
High blood pressure (mother)	1.3	1.8	2.7	-1.4	1.6	0.9
Body mass index (BMI)	0.6	2.7	3.3	1.6	-1.6	-1.8
Impedance of leg (left)	0.1	0.4	0.4	0.7	-0.6	-0.5
Leg predicted mass (left)	0.1	0.4	0.6	-0.8	0.7	0.4
Trunk fat mass	0.2	1.0	2.0	0.8	-0.7	-1.4
Waist circumference	0.6	2.2	2.5	1.3	-1.5	-1.6
Number of incorrect matches in round	0.0	0.0	0.0	-0.1	-0.2	0.1
Past tobacco smoking	2.4	4.4	5.4	-1.9	2.1	2.3
Alcohol usually taken with meals	0.0	0.1	0.1	-0.0	-0.3	0.3
Nervous feelings	0.0	0.0	0.0	0.1	-0.1	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.2	-1.0	0.8	1.5
Hearing difficulty/problems with background noise	0.8	1.3	1.5	1.1	-1.2	-1.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	0.5	-0.0
Had menopause	0.1	0.2	0.4	0.3	-0.6	0.2
Had other major operations	2.8	3.4	4.1	1.9	-1.6	-2.0
Forced vital capacity (FVC)	0.2	0.6	0.8	-0.9	0.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	-0.9	0.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.8	-0.9	0.5	0.5
Qualifications: None of the above	0.4	1.0	1.5	-0.9	1.2	0.8
Financial difficulties in last 2 years	2.6	3.5	3.9	-2.0	1.7	1.9
Mouth/teeth dental problems	0.2	0.4	0.8	-0.5	0.1	0.9
Heart attack	0.0	0.1	0.1	-0.1	0.0	0.4
Allergy	1.0	2.2	2.9	1.7	-1.5	-1.2
Pain all over the body in last month	0.6	0.6	0.9	0.9	-0.6	-0.8
Diabetes (self-reported)	1.3	2.0	3.0	-1.3	1.1	1.7
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.3	1.4	-1.5	-0.9
Medication: Ramipril	2.6	3.4	4.7	1.8	-2.2	-1.5
Medication: Simvastatin	1.7	2.6	2.8	1.7	-1.6	-1.5
Fluid intelligence score	1.0	2.1	2.5	1.6	-1.4	-1.3
Illnesses of siblings	1.4	2.0	2.8	-1.6	1.7	0.8
Neuroticism score	0.3	0.6	0.6	0.6	-0.8	-0.8
Weight	0.1	0.4	0.8	0.4	-0.4	-0.9
Impedance of arm (right)	0.3	1.2	1.8	-1.2	1.4	0.5
Arm fat percentage (right)	0.6	2.3	4.0	1.3	-1.1	-2.0
Trunk fat-free mass	0.0	0.0	0.0	-0.1	0.0	-0.1
Hip circumference	0.0	0.2	0.5	0.2	-0.2	-0.7
Time employed in main current job	1.3	1.5	1.7	-1.1	1.3	1.3
Alcohol intake versus 10 years previously	0.4	0.5	0.8	-0.8	0.3	0.9
Father’s age at death	0.1	0.2	0.2	-0.5	0.3	0.3
Worrier / anxious feelings	0.0	0.0	0.1	-0.3	0.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.7	5.3	-2.3	1.9	2.2
Falls in the last year	0.2	0.3	0.7	0.4	-0.2	-0.8
Hair/balding pattern: Pattern 3	2.8	4.2	5.3	-2.0	1.8	2.3
Number of live births	0.1	0.2	0.6	-0.2	0.1	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.6	-0.8	0.7	0.4
Pulse rate	0.3	0.6	0.8	0.6	-0.8	-0.9
Happiness	0.1	0.1	0.2	-0.2	-0.1	-0.5
Noisy workplace	1.3	1.6	2.6	1.6	-1.2	-0.9
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.4	0.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.4	-0.8	1.2	1.0
Mouth/teeth dental problems: Dentures	0.9	1.5	1.7	1.3	-1.1	-1.3
Asthma	0.2	0.4	0.7	0.6	-0.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.2	-1.5	1.4	1.1
Medication: Cholesterol lowering	0.1	0.2	0.3	0.3	-0.4	-0.5
Depression (self-reported)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Medication: Lansoprazole	0.3	0.4	0.5	0.3	-0.7	-0.7
Prospective memory result	0.0	0.1	0.1	0.1	0.3	0.3
Lung cancer (father)	2.8	3.2	3.5	1.8	-1.9	-1.7
Illnesses of mother	0.0	0.0	0.0	-0.1	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	3.4	-1.9	1.6	1.3
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	0.6	-0.4	-0.8
Impedance of arm (left)	0.2	0.9	1.4	-1.0	1.2	0.4
Arm fat mass (right)	0.4	1.5	2.4	1.1	-1.0	-1.5
Trunk predicted mass	0.0	0.0	0.0	-0.1	0.0	-0.1
Standing height	0.4	3.9	4.8	-2.2	2.0	1.6
Length of working week for main job	0.2	0.2	0.4	0.6	-0.3	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.1	-0.3	0.4
Breastfed as a baby	0.2	0.3	0.4	-0.2	0.6	0.6
Tense / ‘highly strung’	0.5	0.9	1.1	1.0	-1.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.1	0.8	-0.9	-1.0
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	-0.2	0.2	-0.1
Birth weight of first child	0.1	0.1	0.2	0.3	-0.1	-0.5
Peak expiratory flow (PEF)	0.0	0.0	0.0	-0.0	-0.0	0.1
Pulse wave reflection index	0.8	1.0	1.2	-1.1	1.1	0.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.3	0.3	0.4
Loud music exposure frequency	0.0	0.0	0.1	-0.3	-0.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	0.4	-0.6	-0.6
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.1	1.0	-0.9	-1.0
Blood clot in the leg (DVT)	0.6	0.8	1.2	-0.9	0.6	1.1
Medication: Paracetamol	0.6	1.1	1.6	-1.3	0.9	0.8
Headache pain in last month	0.0	0.0	0.1	0.0	0.2	-0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.1	-1.0	1.1	0.9
Glaucoma (self-reported)	0.5	0.6	1.1	-0.7	0.5	1.0
Gout (self-reported)	0.3	0.4	0.5	-0.6	0.4	0.7
Hypothyroidism/myxoedema (self-reported)	3.5	6.8	7.5	-2.5	2.6	2.7
Medication: Amlodipine	0.0	0.0	0.1	0.2	-0.1	-0.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	0.6	-0.5	-0.7
Birth weight	2.0	4.4	5.5	2.4	-1.8	-2.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.3	-0.3	-0.2
High blood pressure (siblings)	3.1	4.4	5.0	2.1	-2.2	-1.9
Forced vital capacity (FVC), Best measure	0.6	2.0	2.5	-1.6	1.5	1.2
Body fat percentage	0.9	3.4	4.7	1.7	-1.6	-2.2
Leg fat percentage (right)	1.8	6.4	8.0	2.4	-2.4	-2.8
Arm fat-free mass (right)	0.0	0.1	0.1	0.3	-0.3	-0.2
Exposure to tobacco smoke outside home	0.5	0.7	0.7	0.8	-0.8	-0.9
Comparative body size at age 10	1.0	2.6	4.1	-1.4	1.4	2.0
Number of full brothers	0.2	0.2	0.4	-0.5	0.6	0.3
Worry too long after embarrassment	0.2	0.4	0.7	0.4	-0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.0	0.8	-0.6	-1.0
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.1	-0.1	0.1
Number of children fathered	0.2	0.3	0.4	-0.4	0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.4	1.0	-1.2	-1.6
Age at first live birth	0.6	1.0	1.6	0.8	-1.0	-1.3
Pulse wave peak to peak time	0.3	0.4	0.6	-0.6	0.3	0.8
Health satisfaction	0.0	0.0	0.1	0.2	-0.2	-0.0
Shortness of breath walking on level ground	2.3	2.7	4.0	-1.7	2.0	1.2
Qualifications: College or University degree	0.1	0.3	0.6	0.5	-0.5	-0.8
Eye problems/disorders: None of the above	0.4	0.4	0.9	0.2	-0.5	-1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.8	0.9	0.9	-0.9	-0.7
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.1	-0.1	-0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	1.4	1.2	-0.7	-0.7
Neck or shoulder pain in last month	0.6	0.9	1.1	-0.9	0.8	1.1
Medication: Blood pressure	0.4	0.7	0.9	0.8	-0.9	-0.7
Angina (self-reported)	0.4	0.5	0.6	0.8	-0.6	-0.7
Migraine (self-reported)	0.3	0.4	0.7	-0.8	0.7	0.2
Medication: Ibuprofen	0.3	0.4	0.6	-0.8	0.7	0.2
Medication: Allopurinol	0.4	0.6	0.8	-0.9	0.5	0.9
Medication: Omeprazole	1.2	1.4	2.0	1.1	-1.4	-1.0
Medication: Seretide 50 evohaler	0.3	0.3	0.5	-0.3	0.7	0.7
Mean time to correctly identify matches	0.1	0.1	0.3	-0.3	0.0	0.5
Heart disease (mother)	0.2	0.2	0.4	-0.4	0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.3	-0.0	0.0
Whole body fat mass	0.4	1.9	2.7	1.2	-1.2	-1.6
Leg fat mass (right)	0.6	2.5	3.6	1.4	-1.4	-1.9
Arm predicted mass (right)	0.0	0.0	0.0	0.1	-0.1	-0.0
Pulse rate, automated reading	0.5	1.6	2.1	-1.2	1.1	1.4
Alcohol intake frequency.	0.0	0.1	0.2	0.4	-0.3	-0.2
Comparative height size at age 10	1.5	8.2	9.3	-3.0	3.0	2.5
Number of full sisters	0.4	0.5	0.6	0.6	-0.8	-0.7
Suffer from ‘nerves’	2.1	3.3	3.7	-1.9	1.9	1.7
Overall health rating	1.1	2.3	2.4	-1.5	1.5	1.5
Chest pain or discomfort	0.7	1.0	1.1	1.1	-0.9	-1.0
Had major operations	0.2	0.2	0.4	-0.3	0.2	0.6
Age at last live birth	0.0	0.0	0.0	-0.0	0.1	-0.1
Family relationship satisfaction	0.0	0.0	0.0	-0.0	-0.0	0.0
Leg pain on walking	0.3	0.4	0.8	-0.9	0.4	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.3	-0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	0.2	-0.3	0.7
Illness, injury, bereavement, stress in last 2 years	3.0	3.7	4.2	2.0	-2.0	-1.7
Medication: Aspirin	0.3	0.5	0.6	-0.7	0.8	0.6
Supplements: Vitamin C	0.2	0.2	0.4	0.5	-0.3	-0.7
Knee pain experienced in last month	0.7	1.0	1.3	-1.1	0.9	1.0
Hypertension (Self-reported)	2.7	7.4	7.8	2.8	-2.7	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	3.1	1.4	-1.8	-1.7
Illnesses of father: Heart disease	0.2	0.3	0.6	0.5	-0.8	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.6	-0.5	-0.0
Smoking status: Previous	3.8	5.7	5.8	2.4	-2.4	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	3.9	-2.0	1.9	1.4
Whole body fat-free mass	0.0	0.0	0.1	-0.3	0.2	0.1
Leg fat-free mass (right)	0.1	0.4	0.5	-0.7	0.7	0.4
Arm fat percentage (left)	0.6	2.4	3.8	1.4	-1.2	-1.9
Average weekly red wine intake	0.5	0.7	0.9	0.8	-0.9	-0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.3	-0.5	-0.4
Mood swings	0.0	0.1	0.1	-0.2	0.1	0.4
Loneliness, isolation	1.6	2.3	3.4	-1.5	1.1	1.8
Long-standing illness, disability or infirmity	1.0	1.6	2.3	-1.1	1.1	1.5
Ever had bowel cancer screening	0.3	0.4	0.7	0.6	-0.8	-0.3
Diabetes diagnosed by doctor	1.5	2.5	3.8	-1.4	1.3	2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	2.7	-1.6	1.6	1.4
Friendships satisfaction	0.6	0.7	1.0	-0.6	1.0	0.8
Qualifications: nursing, teaching	0.5	0.7	1.1	0.9	-1.1	-0.5
Commuting to job workplace: Walk	0.3	0.4	0.5	-0.6	0.7	0.4
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.3	0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.9	0.9	0.5
Medication for cholesterol	1.6	2.4	3.2	-1.8	1.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.2	1.5	-1.8	-0.9
Back pain experienced in last month	0.3	0.4	0.5	-0.7	0.5	0.6
Mineral and other dietary supplements	0.9	1.2	1.5	-1.1	1.2	1.0
Breast cancer (self-reported)	0.1	0.1	0.1	-0.4	-0.0	-0.2
Asthma (self-reported)	0.2	0.5	0.7	0.7	-0.5	-0.8
Osteoporosis (self-reported)	0.9	1.1	1.3	-0.9	1.0	1.2
Osteoarthritis (self-reported)	1.5	1.9	2.8	-1.2	1.7	1.2
Medication: Aspirin	0.1	0.1	0.3	-0.3	0.5	0.1
Medication: Gliclazide	5.9	6.6	7.3	-2.5	2.5	2.7
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.2	0.4	-0.1
Smoking status: Current	2.9	4.6	6.0	-2.4	2.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	-0.2	0.2	0.0
Whole body water mass	0.0	0.0	0.1	-0.3	0.2	0.1
Leg predicted mass (right)	0.1	0.5	0.6	-0.8	0.8	0.5
Arm fat mass (left)	0.5	2.1	3.4	1.3	-1.2	-1.8
Number of self-reported non-cancer illnesses	3.4	5.8	7.2	2.4	-2.7	-2.1
Average weekly champagne plus white wine intake	0.2	0.2	0.2	-0.5	0.4	0.5
Miserableness	0.1	0.1	0.2	0.3	-0.4	-0.2
Guilty feelings	0.5	0.7	1.4	-1.2	0.7	0.4
Wears glasses or contact lenses	0.2	0.2	0.4	0.1	-0.5	-0.6
Ever taken oral contraceptive pill	0.5	0.6	1.1	-1.1	0.8	0.1
Hearing aid user	0.6	0.6	0.7	0.8	-0.8	-0.8
Mother’s age at death	2.3	2.9	3.9	-1.5	1.6	2.0
Financial situation satisfaction	4.2	5.2	5.6	-2.4	2.2	2.2
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.2	-1.1	0.9	1.1
Commuting to job workplace: Public transport	0.0	0.1	0.1	-0.2	0.3	-0.0
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	-0.6	0.5	0.9
Medication: Blood pressure	1.7	3.2	4.2	2.0	-2.0	-1.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.2	-0.5	-0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.3	0.8	-1.0	-1.1
High cholesterol (Self-reported)	1.9	3.4	4.3	2.0	-2.1	-1.4
Medication: Bendroflumethiazide	0.9	1.3	1.8	1.2	-1.3	-0.8
Medication: Paracetamol	0.3	0.5	1.0	-1.0	0.7	0.3
Medication: Lisinopril	0.1	0.1	0.2	0.1	-0.1	0.4
Medication: Atorvastatin	0.4	0.5	0.9	0.7	-0.9	-0.4
Illnesses of father: High blood pressure	0.2	0.2	0.2	-0.5	0.5	0.4
Alcohol drinker status: Never	0.3	0.4	0.8	-0.4	0.9	0.5
Ever smoked	0.4	0.7	1.2	0.5	-0.8	-1.1
Basal metabolic rate	0.0	0.0	0.0	-0.1	0.0	-0.2
Leg fat percentage (left)	1.9	7.0	7.7	2.6	-2.5	-2.8
Arm fat-free mass (left)	0.0	0.1	0.1	0.4	-0.4	-0.3
Number of operations (self-reported)	2.8	4.1	4.4	2.0	-1.9	-2.1
Average weekly beer plus cider intake	0.1	0.1	0.4	0.1	-0.6	0.0
Irritability	0.3	0.5	0.5	0.7	-0.7	-0.6
Risk taking	0.9	1.2	1.8	1.1	-1.3	-0.8
Ever had prostate specific antigen (PSA) test	1.6	1.9	2.2	-1.5	1.4	1.2
Fractured/broken bones in last 5 years	1.8	2.4	3.0	-1.7	1.3	1.5
Age started oral contraceptive pill	0.1	0.2	0.2	0.3	-0.5	-0.4
Diastolic blood pressure, automated reading	3.5	11.0	12.2	3.3	-3.1	-3.5
Ever depressed for a whole week	0.1	0.1	0.3	-0.5	0.2	0.0
Unable to work because of sickness or disability	0.2	0.2	0.2	0.5	-0.5	-0.3
Commuting to job workplace: Cycle	2.7	3.3	3.8	1.6	-1.9	-1.9
Myopia	0.2	0.3	0.7	0.3	-0.8	-0.2
Vascular/heart problems diagnosed by doctor	2.7	7.3	8.2	-2.7	2.9	2.5
Cholesterol lowering medication	5.5	8.1	9.4	3.1	-3.1	-2.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.0	1.1	-1.4	-1.1
Pain experienced in last month	0.0	0.0	0.0	-0.2	0.2	0.2
Supplements: Calcium	1.2	1.4	1.6	-1.3	1.2	1.0
Basal cell carcinoma (self-reported)	4.5	5.4	5.7	-2.4	2.3	2.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.0	-0.0	0.4
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	2.8	-1.3	1.2	1.7
Heart disease (siblings)	0.1	0.1	0.3	0.5	-0.1	-0.2
Alcohol drinker status: Previous	1.2	1.4	2.2	1.5	-1.3	-0.6
Pack years of smoking	1.3	1.9	2.4	1.6	-1.4	-1.2
Impedance of whole body	0.0	0.0	0.1	-0.2	0.3	-0.1
Leg fat mass (left)	0.7	2.7	3.5	1.6	-1.5	-1.9
Arm predicted mass (left)	0.0	0.0	0.0	0.2	-0.2	-0.2