TWAS hub - JHDM1D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0541	0.0230	1.4e-03	0.013	0.015	0.014	0.016	0.013	3.6e-03	2.0e-03	2.6e-03	1.4e-03	3.8e-03
2	NTR	Blood	0.0233	0.0102	5.0e-03	0.021	0.009	0.015	0.016	0.017	1.3e-07	3.6e-04	9.9e-06	5.1e-06	2.4e-06
3	ROSMAP	Brain Pre-frontal Cortex	0.1395	0.0394	9.8e-06	0.074	0.049	0.115	0.120	0.106	9.0e-10	5.4e-07	1.4e-14	3.6e-15	1.6e-13
4	TCGA	Breast Invasive Carcinoma	0.0487	0.0223	1.5e-03	0.007	0.014	0.009	NA	0.005	1.2e-02	5.9e-04	4.5e-03	NA	2.7e-02
5	TCGA	Thyroid Carcinoma	0.1430	0.0650	1.0e-04	0.011	0.042	0.032	NA	0.012	2.7e-02	6.2e-05	4.0e-04	NA	2.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Irritability	6.1	10.3	18.2	-1.2	-3.4	-3.1	-4.3	-3.3
Rheumatoid Arthritis	5.7	7.8	14.0	0.8	1.8	3.3	3.2	3.7
Angina	4.6	6.0	16.8	0.3	-0.0	2.4	2.7	4.1
Lung FEV1/FVC ratio	4.5	22.9	52.0	-2.0	-0.9	-6.1	-4.5	-7.2
Angina (self-reported)	4.5	5.9	16.6	-0.0	-0.2	2.4	2.6	4.1
Heart attack/myocardial infarction (self-reported)	4.0	5.1	11.4	1.0	0.0	2.0	3.1	3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.5	12.7	0.8	1.4	1.9	1.9	3.6
Hair/balding pattern: Pattern 4	3.7	8.9	14.8	-0.3	3.1	3.9	2.6	3.6
Heart attack	3.6	4.6	10.0	1.4	0.1	1.7	2.9	3.2
Suffer from ‘nerves’	3.5	5.5	11.1	3.3	2.1	2.2	1.2	2.4
Medication: Atorvastatin	3.5	4.4	7.3	1.9	1.6	2.0	2.7	2.2
High blood pressure (siblings)	3.4	4.9	10.8	2.8	3.3	1.4	1.3	1.5
Knee pain experienced in last month	3.3	5.2	14.7	-0.5	1.2	2.0	3.8	2.3
Deep venous thrombosis (DVT) (self-reported)	3.2	4.2	11.0	0.6	1.1	1.1	3.3	2.6
Blood clot in the leg (DVT)	3.0	3.9	10.0	0.8	0.5	1.0	3.2	2.8
Miserableness	2.8	4.8	8.4	0.7	-2.1	-2.9	-2.6	-2.0
Schizophrenia vs Biploar Disorder	2.7	3.5	5.9	1.6	1.2	2.1	2.4	1.9
Tense / ‘highly strung’	2.6	4.4	10.9	1.8	-1.0	-1.9	-3.3	-1.8
Chronotype (morning person)	2.5	5.8	10.5	-1.0	0.6	3.2	2.7	3.1
Relative age of first facial hair	2.5	5.2	9.2	-1.9	-0.4	-2.8	-2.2	-3.0
Illnesses of siblings	2.5	3.6	11.3	-3.4	-1.5	-1.0	-1.1	-1.3
Falls in the last year	2.5	3.4	9.5	0.8	1.1	1.1	3.1	2.0
Number of operations (self-reported)	2.4	3.5	6.8	-1.8	-0.6	1.5	2.3	2.6
Heart disease (siblings)	2.4	3.0	12.8	3.6	-0.2	0.6	0.5	1.2
Body Mass Index (BMI) (2010)	2.3	3.1	6.6	0.7	1.4	1.6	2.6	1.9
Blood Platelet Count	2.3	27.2	49.6	-3.3	-2.0	-5.4	-7.0	-6.5
Had other major operations	2.3	2.8	8.8	-3.0	-0.3	0.6	1.4	1.8
Qualifications: None of the above	2.3	4.8	10.2	0.7	1.6	3.2	2.7	2.0
Supplements: Fish oil (including cod liver oil)	2.3	3.0	12.5	-0.2	1.5	-0.1	3.5	0.3
Alcohol intake versus 10 years previously	2.2	3.2	6.9	1.0	2.1	1.6	1.2	2.6
Current tobacco smoking	2.1	3.4	5.6	0.7	0.9	2.4	2.2	2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	3.8	-0.8	-1.1	-1.8	-2.0	-1.9
Commuting to job workplace: Car/motor vehicle	2.1	2.4	4.9	-0.3	0.1	1.7	2.2	2.1
Hypothyroidism (self reported)	2.0	4.5	9.9	3.1	1.1	0.9	2.6	2.0
Taking other prescription medications	2.0	3.0	5.7	0.6	0.2	1.9	2.3	2.4
Financial situation satisfaction	2.0	2.5	7.8	-0.1	0.3	-2.8	-1.0	-1.9
Happiness	1.9	2.3	3.3	1.6	-1.8	-1.6	-0.3	-1.7
Ever highly irritable/argumentative for 2 days	1.9	2.3	5.4	-0.4	-0.6	-1.5	-1.9	-2.3
Chronic bronchitis/emphysema (mother)	1.9	2.2	6.8	0.3	0.8	2.6	1.3	1.3
Illnesses of father: Heart disease	1.9	2.7	5.4	-0.5	-2.3	-1.8	-1.7	-1.3
Medication: Levothyroxine sodium	1.8	3.0	4.5	2.0	1.3	0.7	2.1	2.1
Age at First Birth	1.7	2.5	9.1	-3.0	0.5	0.2	-1.1	-1.5
Medication for hormone replacement therapy	1.7	1.9	4.0	1.5	0.9	1.3	0.7	2.0
Diabetes (father)	1.7	2.1	4.5	-2.1	-1.9	0.2	-1.0	1.1
Bipolar Disorder (2018)	1.6	2.5	5.1	-1.6	-1.3	-1.6	-2.2	-0.9
Coronary Artery Disease (CAD)	1.6	1.9	3.7	-0.4	1.9	1.7	0.7	1.5
Hearing difficulty/problems: Yes	1.6	2.5	3.5	1.9	1.4	1.5	1.9	1.2
Supplements: Glucosamine	1.6	2.1	3.3	1.5	-1.7	-1.3	1.8	-0.7
Birth weight of first child	1.6	2.8	3.8	2.0	1.7	1.3	1.6	1.8
Mouth/teeth dental problems: Loose teeth	1.6	2.0	4.4	-0.1	2.0	2.1	0.7	1.0
BMI	1.5	8.5	13.2	1.1	3.0	3.0	3.6	3.2
Stomach or abdominal pain in last month	1.5	1.9	5.7	2.4	1.0	-0.5	0.3	-1.5
Hip circumference	1.5	6.3	11.2	-0.0	1.5	2.8	3.3	3.2
Pulse rate	1.5	2.5	5.9	2.4	-0.3	-1.9	-0.9	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	7.7	2.8	-0.3	-0.7	-0.8	-0.4
Ever had bowel cancer screening	1.5	1.7	6.1	2.5	0.5	0.0	1.5	0.2
Friendships satisfaction	1.5	1.8	8.4	2.9	-0.1	-0.2	0.8	0.0
Mineral and other dietary supplements	1.5	2.0	9.3	-0.3	-0.3	-0.1	-3.1	-0.8
Hearing aid user	1.5	1.8	3.8	-0.9	-0.5	1.7	0.9	1.9
Prostate Cancer	1.4	2.0	3.6	1.4	1.9	1.7	1.0	0.7
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.5	-0.2	-1.4	-1.5	-0.7	-1.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.3	-1.7	-1.5	-0.2	-1.8	-0.9
Medication: Amlodipine	1.4	1.9	3.9	1.4	0.3	1.3	2.0	1.4
Qualifications: College or University degree	1.4	4.5	6.6	-1.7	-2.6	-2.2	-2.5	-1.6
Chest pain or discomfort	1.4	2.0	4.5	1.2	-0.6	-2.1	-1.5	-1.3
Family relationship satisfaction	1.4	1.7	4.1	2.0	-0.6	-1.3	0.4	-1.5
Breast cancer (self-reported)	1.4	1.7	4.7	-0.2	0.1	0.5	2.2	1.8
Supplements: Zinc	1.3	1.4	2.8	-0.9	1.7	0.8	1.2	1.1
Qualifications: CSEs or equivalent	1.3	1.7	3.7	1.4	-0.1	1.1	1.2	1.9
Neuroticism score	1.3	2.8	6.6	2.6	-1.0	-1.6	-1.9	-0.7
Hair/balding pattern: Pattern 3	1.3	2.0	4.2	-2.0	0.9	0.8	1.6	1.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.4	7.1	2.7	1.1	0.1	1.5	1.2
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.0	1.2	0.7	1.2	1.4	1.7
Worry too long after embarrassment	1.3	2.2	5.2	1.4	-1.1	-1.6	-2.3	-0.6
Wheeze or whistling in the chest in last year	1.3	2.4	2.8	1.6	-1.7	-1.5	-1.3	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.1	-1.8	-1.0	-1.4	0.4	-0.8
Smoking status: Current	1.3	2.1	3.4	0.6	0.4	1.8	1.8	1.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	4.2	2.0	-0.8	-0.9	-0.1	-0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	5.2	-0.2	2.3	0.6	1.3	0.3
Impedance of arm (right)	1.2	5.4	12.8	-1.2	-3.1	-1.1	-3.6	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.2	1.0	1.8	0.9	1.4	1.7
Arm predicted mass (right)	1.2	6.3	14.4	0.1	0.4	2.9	3.8	3.0
Back pain experienced in last month	1.2	1.8	3.7	-1.5	-0.3	-1.5	-1.0	-1.9
Arm fat-free mass (left)	1.2	6.1	16.7	-0.2	0.7	2.4	4.1	2.8
Arm predicted mass (left)	1.2	5.9	15.2	-0.2	0.8	2.5	3.9	2.7
Worry (Nagel 2018)	1.1	2.3	10.8	3.3	0.7	-0.3	-0.4	-0.1
HbA1C	1.1	1.2	4.2	0.6	2.0	-0.8	0.8	0.3
Respiratory disease	1.1	2.5	4.7	0.0	0.8	1.9	2.2	1.9
Systolic blood pressure, automated reading	1.1	3.1	9.2	3.0	2.3	0.5	0.8	0.4
Body mass index (BMI)	1.1	4.6	6.9	1.4	2.6	1.6	2.6	2.2
Number of incorrect matches in round	1.1	1.9	4.5	-0.1	2.1	1.6	1.5	0.4
Weight	1.1	5.6	9.4	0.3	1.0	3.0	3.1	2.9
Arm fat-free mass (right)	1.1	5.6	12.3	0.0	0.6	2.9	3.5	2.6
Age at last live birth	1.1	1.6	5.0	-2.2	-1.2	-0.8	-0.3	-0.8
Loneliness, isolation	1.1	1.5	2.8	1.3	0.4	1.3	0.9	1.7
Guilty feelings	1.1	1.6	6.9	2.6	-0.6	-0.3	0.1	0.8
Ever depressed for a whole week	1.1	1.3	3.3	1.8	0.7	-0.0	1.4	1.0
Neuroticism (Nagel 2018)	1.0	2.5	5.6	2.4	-1.4	-1.4	-1.6	-0.5
Diabetes (mother)	1.0	1.3	2.3	-0.2	-1.5	-1.4	-1.5	0.1
Serious illness, injury or assault to yourself	1.0	1.3	2.9	-1.7	-0.2	0.6	1.2	1.3
Trunk fat mass	1.0	4.1	8.6	0.3	0.9	2.5	2.2	2.9
Worrier / anxious feelings	1.0	1.9	4.3	2.1	-0.5	-1.4	-1.5	-0.9
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.7	0.0	-1.1	-1.9	-1.9	-1.6
Length of working week for main job	1.0	1.1	2.4	-0.9	1.4	-0.4	1.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.3	-0.0	-1.6	-1.3	-1.8	-0.2
Leg fat mass (right)	1.0	4.0	7.8	0.5	1.5	1.9	2.8	2.4
Commuting to job workplace: Walk	1.0	1.0	3.4	0.6	1.9	1.1	0.0	0.4
Medication for cholesterol	1.0	1.6	5.7	-2.4	-0.1	-0.6	-1.0	-0.9
Average weekly champagne plus white wine intake	1.0	1.4	3.5	-1.8	-1.9	0.1	-0.2	-0.4
Wears glasses or contact lenses	1.0	1.1	3.5	-0.8	-1.9	-1.0	-0.5	-0.4
Basal metabolic rate	1.0	5.4	10.6	-0.3	0.5	3.0	3.2	2.8
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.5	-0.5	2.1	0.5	0.8	0.4
Lupus	0.9	1.3	2.8	1.4	-0.5	1.2	0.6	1.7
Neuroticism	0.9	2.1	3.8	1.9	-1.2	-1.9	-1.1	-0.6
Leg fat-free mass (left)	0.9	4.8	9.9	-0.6	0.6	3.1	2.6	2.6
Trunk fat percentage	0.9	3.5	7.7	0.5	1.1	2.1	1.8	2.8
Leg predicted mass (left)	0.9	5.0	10.1	-0.5	0.6	3.2	2.7	2.7
Waist circumference	0.9	3.4	6.0	0.7	1.2	1.8	2.4	2.5
Alcohol usually taken with meals	0.9	1.4	1.9	-1.4	-1.2	0.2	1.4	1.4
Financial difficulties in last 2 years	0.9	1.2	3.4	-1.0	-0.3	-1.8	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	5.6	-2.4	-1.0	-1.2	-1.4	-2.2
Arm fat mass (right)	0.9	3.7	7.2	0.5	1.6	1.9	2.7	2.2
Breastfed as a baby	0.9	1.1	3.3	-1.8	0.8	-0.3	-1.3	-0.2
Peak expiratory flow (PEF)	0.9	2.1	4.1	-0.7	-0.3	-1.8	-1.6	-2.0
Leg fat percentage (right)	0.9	3.3	5.3	1.4	1.9	1.1	2.3	2.1
Exposure to tobacco smoke outside home	0.9	1.1	2.2	1.3	-1.3	-0.4	1.5	0.1
Number of full brothers	0.9	1.2	3.1	0.1	0.5	1.5	0.4	1.8
Number of children fathered	0.9	1.0	4.1	0.6	2.0	-0.2	0.8	-0.1
Whole body fat mass	0.9	3.6	6.2	0.5	1.1	2.0	2.5	2.5
Pulse rate, automated reading	0.9	2.8	10.0	3.2	1.2	-1.3	0.6	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.4	-0.3	-0.6	-1.1	-0.4	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	5.7	-0.7	0.8	-1.5	-0.1	-2.4
Whole body water mass	0.9	4.9	10.0	-0.4	0.3	2.8	3.2	2.6
Arm fat mass (left)	0.9	3.8	6.8	0.3	1.5	1.9	2.6	2.5
Mother’s age at death	0.9	1.1	3.4	-1.8	1.1	-0.8	-0.1	-0.4
Leg fat mass (left)	0.9	3.6	6.6	0.5	1.6	1.9	2.6	2.3
Mean Putamen Volume	0.8	0.9	3.4	0.5	1.8	0.0	0.9	-0.1
HDL Cholesterol	0.8	1.4	3.9	-2.0	-1.3	0.8	0.3	0.6
LDL Cholesterol	0.8	1.2	3.9	0.8	2.0	0.9	0.8	0.1
Primary Biliary Cirrhosis	0.8	1.2	4.2	0.4	2.0	0.9	0.3	0.7
Sensitivity / hurt feelings	0.8	1.3	2.0	1.4	-1.1	-1.4	0.1	1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	-0.8	-1.2	1.0	0.5	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.4	1.5	0.6	-0.2	0.3	1.6
Relative age voice broke	0.8	1.2	2.7	-1.6	-0.5	-1.3	-0.5	-1.1
Hearing difficulty/problems with background noise	0.8	1.3	3.5	1.9	-1.2	-0.6	-0.9	-0.6
Hair/balding pattern: Pattern 2	0.8	1.0	3.8	1.9	-0.6	0.1	-1.0	-0.0
Impedance of arm (left)	0.8	3.8	9.7	-1.5	-2.6	-0.3	-3.1	-0.9
Body fat percentage	0.8	3.2	6.2	0.7	1.5	1.7	2.0	2.5
Neck or shoulder pain in last month	0.8	1.1	3.8	2.0	1.0	0.2	0.9	-0.1
Illnesses of siblings: Diabetes	0.8	1.0	1.6	0.2	1.3	1.2	0.7	1.3
Whole body fat-free mass	0.8	4.8	9.9	-0.3	0.3	2.8	3.1	2.5
Long-standing illness, disability or infirmity	0.8	1.3	2.9	1.6	-0.3	0.5	0.7	1.7
Leg predicted mass (right)	0.8	4.1	9.2	-0.7	0.7	3.0	2.3	2.2
Illnesses of father: High blood pressure	0.8	1.0	2.7	-1.6	0.1	-0.9	-0.6	-1.1
Leg fat percentage (left)	0.8	3.0	5.3	1.3	2.3	1.1	2.0	1.7
Cholesterol lowering medication	0.8	1.2	4.0	2.0	0.5	0.2	1.0	0.9
Depressed Affect (Nagel 2018)	0.7	1.4	3.6	1.5	-1.9	-0.8	-0.8	-0.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.4	0.6	0.9	0.6	1.2	1.1
Neuroticism (2016)	0.7	1.0	3.1	1.8	0.6	0.1	-1.2	-0.1
Heel T-Score	0.7	5.7	8.2	-2.6	-2.6	-2.4	-1.1	-2.9
Cardiovascular Disease	0.7	2.2	5.9	2.4	-1.0	-1.1	-1.3	-1.0
Severe depression (siblings)	0.7	0.8	1.3	0.0	1.1	1.0	0.8	0.9
Townsend deprivation index at recruitment	0.7	1.0	3.4	0.1	1.8	0.5	1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	6.0	-2.5	-0.2	-0.2	-1.4	-0.6
Impedance of leg (left)	0.7	3.2	6.7	-0.3	-2.6	-1.7	-2.2	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.4	-1.2	-0.8	-0.7	-2.3	-0.6
Trunk fat-free mass	0.7	4.1	9.0	-0.2	-0.0	2.5	3.0	2.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	6.3	-2.5	-1.3	-1.0	-0.7	-1.6
Mouth/teeth dental problems: Dentures	0.7	1.1	2.6	0.4	0.6	1.4	0.7	1.6
Depression (self-reported)	0.7	0.8	2.6	0.5	-1.6	-0.1	0.3	1.1
Trunk predicted mass	0.7	4.1	9.2	-0.2	-0.1	2.4	3.0	2.3
Medication: Seretide 50 evohaler	0.7	0.7	1.5	-1.2	-0.3	0.5	0.7	1.2
Supplements: Vitamin C	0.7	0.8	1.4	0.7	0.1	1.2	1.1	1.0
Leg fat-free mass (right)	0.7	4.0	8.9	-0.8	0.5	3.0	2.3	2.2
Medication: Blood pressure	0.7	1.3	4.8	2.2	0.3	0.8	0.4	0.8
Average weekly beer plus cider intake	0.7	1.0	4.2	2.0	-0.2	0.1	-0.0	0.9
Fractured/broken bones in last 5 years	0.7	0.9	3.0	-0.1	-0.8	0.6	0.8	1.7
Impedance of whole body	0.7	3.4	7.8	-0.9	-2.8	-0.8	-2.6	-0.8
Depression (Nagel 2018)	0.6	0.9	2.4	1.6	-0.6	-1.2	-0.1	0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.1	0.9	-1.5	0.3	0.0	0.1
Ovarian Cancer	0.6	0.7	2.2	-0.1	-1.5	1.2	-0.1	0.1
Crohns Disease (2012)	0.6	1.0	4.3	0.1	-2.1	0.0	-0.6	-0.1
Systolic Blood Pressure	0.6	3.2	13.9	3.7	1.3	0.0	-0.5	-0.3
Hand grip strength (left)	0.6	1.5	5.9	-0.3	2.4	1.1	0.3	-0.1
Impedance of leg (right)	0.6	3.0	8.3	-0.0	-2.9	-1.7	-1.7	-0.9
Maternal smoking around birth	0.6	0.8	1.7	0.3	1.0	-0.9	0.8	-1.3
Fed-up feelings	0.6	1.0	2.7	1.7	-0.9	-0.4	-1.2	-0.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-0.1	-0.2	1.1	0.5	1.4
Mouth/teeth dental problems	0.6	1.0	1.8	0.1	-1.1	-1.4	-0.5	-1.3
Pain all over the body in last month	0.6	0.6	1.7	-0.1	1.3	0.1	0.8	0.9
Number of live births	0.6	0.8	3.0	0.6	0.1	0.5	1.7	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.3	-0.5	-0.4	-1.5	1.0	-0.5
Standing height	0.6	5.9	9.9	-2.4	-3.0	3.1	1.1	1.8
Glaucoma (self-reported)	0.6	0.7	1.5	-0.6	0.8	-1.2	0.7	-0.7
Mean time to correctly identify matches	0.6	1.1	4.3	0.2	0.6	0.7	2.1	0.7
Comparative height size at age 10	0.6	3.6	7.2	-0.4	-1.6	2.7	2.0	2.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.2	-0.7	-0.4	0.9	-1.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.6	0.6	-2.4	-0.4	0.1	-0.7
Arm fat percentage (left)	0.6	2.4	4.4	0.7	1.6	1.5	1.5	2.1
Diabetes diagnosed by doctor	0.6	1.0	3.5	-0.5	-1.9	-0.3	-1.1	0.3
Eye problems/disorders: Glaucoma	0.6	0.7	2.5	-0.3	0.1	-0.5	1.6	0.9
Medication: Bendroflumethiazide	0.6	0.9	2.8	1.7	-0.5	0.8	0.2	1.0
Commuting to job workplace: Cycle	0.6	0.7	1.2	0.0	1.0	1.0	-0.6	1.1
Alcohol drinker status: Previous	0.6	0.7	1.8	0.1	-1.0	0.8	0.4	1.3
Bipolar Disorder or Schizophrenia	0.5	1.1	2.2	0.4	-0.3	-1.5	-1.5	-1.0
Intelligence (Savage-Jansen 2018)	0.5	1.6	4.4	-0.4	0.3	-1.8	-0.6	-2.1
Major Depression (MDD)	0.5	0.5	1.3	0.9	-0.7	0.4	1.2	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.9	-0.8	0.8	-1.7	-0.5	-1.1
Height	0.5	10.0	22.5	-4.0	-4.7	3.0	0.7	1.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.9	-0.8	-1.7	0.1	-0.9	0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	0.8	-0.5	1.1	0.1	1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.6	0.3	0.2	1.3	0.7	1.0
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	-0.1	0.9	-0.6	0.8	-0.8
Average weekly fortified wine intake	0.5	0.6	1.1	-1.1	0.9	0.7	0.3	0.5
High blood pressure (mother)	0.5	0.7	2.5	0.8	-0.3	-1.6	0.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.9	1.4	0.2	-0.7	-1.0	0.4
Forced vital capacity (FVC)	0.5	1.9	4.6	-2.1	-1.6	0.8	1.2	0.6
Arm fat percentage (right)	0.5	2.1	3.2	0.9	1.6	1.1	1.7	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.9	1.4	-0.4	-0.2	0.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.7	0.7	-0.3	0.6	-0.7	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.8	-0.3	-1.3	-1.1	0.3	-0.5
Age at first live birth	0.5	0.9	1.4	-1.2	-1.1	-0.6	-1.2	0.1
Emphysema/chronic bronchitis	0.5	0.6	1.9	0.3	0.3	0.8	1.4	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	3.1	1.0	0.6	1.8	-0.4	0.3
Number of full sisters	0.5	0.6	0.9	0.8	0.6	-1.0	-0.5	-0.9
Asthma (self-reported)	0.5	1.0	1.8	0.3	0.5	1.1	1.3	1.3
Osteoporosis (self-reported)	0.5	0.6	1.4	0.8	-0.8	0.6	1.2	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	2.7	1.6	-1.3	-0.3	0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.0	1.4	0.5	0.6	0.3	0.2
Medication: Lisinopril	0.5	0.6	2.0	1.4	-0.2	-0.2	0.6	0.7
Pain experienced in last month	0.5	0.9	2.8	-0.1	0.2	-0.2	-1.7	-1.2
Schizophrenia (2018)	0.4	0.8	2.7	1.7	0.7	-0.6	-0.1	-0.6
Reaction Time	0.4	0.7	1.8	0.4	-0.1	1.3	1.1	0.7
Breast Cancer	0.4	1.0	2.2	1.5	-0.9	1.3	-0.3	-0.6
Ulcerative Colitis	0.4	0.5	2.0	-0.3	0.5	-0.0	-1.4	0.6
Blood White Count	0.4	2.6	7.0	1.1	1.0	-1.3	-2.6	-1.4
Average weekly spirits intake	0.4	0.5	1.1	0.6	0.5	0.9	1.0	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.2	1.5	-0.0	0.0	-0.8	0.6
Medication: Metformin	0.4	0.6	1.0	0.4	-0.9	1.0	-0.9	0.5
Age when periods started (menarche)	0.4	1.0	2.2	-0.9	0.2	0.6	1.5	1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	1.0	-0.0	0.9	0.4	0.5
Multivitamins +/- minerals	0.4	0.5	1.1	-0.6	0.7	0.0	1.1	0.6
Medication: Atenolol	0.4	0.4	1.3	-0.1	1.1	0.6	0.8	0.2
Sitting height	0.4	3.1	4.8	-1.5	-2.1	2.2	0.9	1.8
Diabetes (self-reported)	0.4	0.6	2.9	-0.2	-1.7	-0.0	-0.3	0.4
Medication: Ramipril	0.4	0.5	1.9	-0.0	-1.4	0.3	0.4	0.8
Medication: Simvastatin	0.4	0.6	1.9	0.4	-1.4	-0.1	-0.9	-0.5
Fluid intelligence score	0.4	0.7	2.1	-0.1	0.8	-1.0	0.3	-1.4
Asthma	0.4	0.8	1.4	0.1	0.5	1.0	1.2	1.2
Prospective memory result	0.4	0.5	0.7	0.8	0.8	0.6	0.6	0.4
Lung cancer (father)	0.4	0.4	1.4	0.4	0.4	-0.4	-0.5	-1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.2	0.2	1.5	-0.2	-0.4	-0.3
Birth weight	0.4	0.8	3.0	-0.6	-0.2	0.7	1.7	0.5
Migraine (self-reported)	0.4	0.5	1.6	0.0	0.7	-0.2	-1.3	-0.6
Medication: Ibuprofen	0.4	0.4	1.7	-0.5	-0.3	-1.3	0.1	-0.4
Leg pain on walking	0.4	0.5	1.5	-0.5	-0.7	-0.3	0.4	1.2
Hypertension (Self-reported)	0.4	1.0	3.8	1.9	0.3	0.2	-1.0	0.1
Qualifications: nursing, teaching	0.4	0.6	1.8	-1.4	-0.0	-0.2	0.7	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.3	-1.5	-0.4	-0.5	-0.5	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.5	1.1	0.2	0.2	-1.0
Ever taken oral contraceptive pill	0.4	0.4	1.4	0.1	-1.2	-0.6	0.2	-0.6
Diastolic blood pressure, automated reading	0.4	1.3	4.3	2.1	1.4	-0.3	0.0	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.3	-2.1	-0.4	-0.7	-0.2	-1.1
Supplements: Calcium	0.4	0.4	0.7	-0.8	-0.6	0.0	0.8	0.6
Crohns Disease (2017)	0.3	0.7	1.7	1.3	-1.1	-0.3	-0.2	0.5
Ulcerative Colitis (UC)	0.3	0.5	2.0	0.4	0.3	0.5	-0.3	1.4
Fasting Glucose	0.3	0.4	0.7	0.8	0.4	-0.8	0.3	-0.7
Triglycerides	0.3	0.4	1.1	1.1	-0.4	-0.4	-0.6	0.6
Smoking Status	0.3	0.8	2.0	0.1	0.1	0.6	1.3	1.4
Number of treatments/medications taken	0.3	0.6	1.0	0.8	-0.6	-0.1	0.9	1.0
Vitamin and mineral supplements	0.3	0.4	1.3	-0.2	-0.3	0.3	-1.1	-0.7
Pack years adult smoking proportion	0.3	0.5	1.7	0.5	-0.1	0.9	-0.1	1.3
High blood pressure	0.3	0.9	3.6	1.9	0.7	0.4	-0.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	0.9	-0.2	-0.8	-0.0	0.0
Allergy	0.3	0.6	1.1	-0.5	-0.4	-1.0	-1.0	-0.6
Noisy workplace	0.3	0.4	0.7	0.1	0.4	0.7	0.7	0.8
Illnesses of mother	0.3	0.4	0.9	-0.9	-0.2	0.7	0.8	-0.4
Headache pain in last month	0.3	0.5	1.0	1.0	-0.4	-0.2	0.7	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	0.7	-0.6	0.9	0.8	0.6	0.9
Gout (self-reported)	0.3	0.4	1.1	1.1	-0.4	-0.7	0.2	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	2.9	-1.7	-1.1	0.9	0.6	0.2
Health satisfaction	0.3	0.4	1.3	0.6	-1.1	-0.5	-0.1	0.1
Eye problems/disorders: None of the above	0.3	0.4	1.4	0.0	-0.3	-0.3	-1.2	-0.5
Heart disease (mother)	0.3	0.4	0.7	0.8	-0.6	0.1	-0.5	0.9
Medication: Aspirin	0.3	0.4	1.3	-0.3	-1.2	-0.3	-0.6	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.6	-0.3	1.3	0.4	0.2	-0.3
Mood swings	0.3	0.6	1.5	-0.0	-1.0	0.5	-1.2	0.5
Eye problems/disorders: Cataract	0.3	0.4	1.3	0.1	0.8	-0.1	0.0	-1.1
Medication: Aspirin	0.3	0.4	0.9	0.3	-0.9	-0.7	-0.7	-0.2
Medication: Gliclazide	0.3	0.4	0.8	-0.0	0.9	0.9	-0.3	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.4	0.1	-1.2	0.0	0.2	-0.6
High cholesterol (Self-reported)	0.3	0.5	2.1	0.2	0.3	0.3	1.4	0.5
Alcohol drinker status: Never	0.3	0.3	1.0	0.3	0.6	0.1	-1.0	-0.3
Ever smoked	0.3	0.6	1.3	-0.7	-0.3	0.9	0.2	1.1
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	-0.1	0.6	0.8	0.4	-0.6
Irritable Bowel Disease (IBD)	0.2	0.4	1.3	0.7	-0.6	0.1	-0.3	1.2
Bipolar Disorder (2011)	0.2	0.2	1.0	0.0	-0.4	0.0	-1.0	0.1
Schizophrenia (2014)	0.2	0.5	2.2	1.5	0.3	-0.3	-0.4	0.4
Blood Red Count	0.2	2.3	4.8	1.2	-0.8	-2.2	-1.4	-1.7
Waist Hip Ratio (WHR)	0.2	1.1	2.3	-0.0	-1.2	-0.9	-1.5	-1.0
Hair Pigment	0.2	5.7	19.1	-0.7	4.4	1.7	1.8	1.6
Medication: Co-codamol	0.2	0.2	0.7	0.3	-0.6	0.3	-0.8	-0.1
Past tobacco smoking	0.2	0.3	0.9	-0.1	-0.4	-0.1	-0.7	-0.9
Nervous feelings	0.2	0.4	1.4	1.2	0.5	0.5	0.0	0.4
Had menopause	0.2	0.3	0.7	-0.8	-0.6	-0.2	-0.7	0.0
Medication: Cholesterol lowering	0.2	0.3	1.6	0.1	-1.2	-0.1	-0.4	-0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.3	0.3	0.4	0.3	0.7
Exposure to tobacco smoke at home	0.2	0.3	0.6	0.8	-0.8	-0.2	-0.0	0.2
Loud music exposure frequency	0.2	0.3	0.5	0.5	0.1	-0.7	-0.4	-0.6
Comparative body size at age 10	0.2	0.6	1.2	0.9	-1.1	0.6	0.3	0.7
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.1	0.0	0.6	0.0	0.9
Medication: Allopurinol	0.2	0.3	0.9	0.6	-0.9	-0.4	0.2	0.5
Average weekly red wine intake	0.2	0.3	0.7	-0.8	0.4	0.8	0.2	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.9	-0.0	-0.8	0.2	0.9	0.2
Medication: Paracetamol	0.2	0.3	0.5	-0.5	-0.4	-0.5	-0.7	-0.7
Risk taking	0.2	0.3	1.4	-0.3	0.3	-1.2	0.2	0.0
Age started oral contraceptive pill	0.2	0.2	0.6	0.5	-0.0	0.2	-0.8	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.7	0.1	-0.3	0.1	-0.9	0.5
Myopia	0.2	0.3	0.5	0.6	0.5	0.4	-0.7	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	0.4	-0.3	-0.4	0.6	-0.8
Pack years of smoking	0.2	0.4	1.1	0.1	0.1	0.8	-0.0	1.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.5	-0.5	0.6	0.2	0.5
Blood Eosinophil Count	0.1	1.1	2.7	0.7	1.0	-1.2	-1.6	-0.3
Allergy or Eczema	0.1	0.3	0.6	-0.6	0.2	0.8	0.6	0.1
Lung FVC	0.1	0.6	1.6	-0.9	0.6	-0.3	1.3	0.2
Hand grip strength (right)	0.1	0.4	0.9	-0.3	0.6	0.1	-0.9	-0.7
Time employed in main current job	0.1	0.2	0.4	-0.5	0.7	0.0	-0.0	-0.2
Father’s age at death	0.1	0.1	0.3	-0.3	0.2	-0.5	-0.2	-0.1
Medication: Lansoprazole	0.1	0.1	0.5	0.3	0.0	0.3	-0.1	-0.7
Medication: Paracetamol	0.1	0.2	0.8	-0.9	0.0	-0.6	-0.2	-0.1
Pulse wave peak to peak time	0.1	0.1	0.3	-0.0	-0.5	-0.1	-0.2	-0.5
Medication: Blood pressure	0.1	0.2	0.7	0.8	-0.3	0.2	0.2	0.0
Alcohol intake frequency.	0.1	0.2	0.3	0.3	0.4	0.5	0.4	0.5
Overall health rating	0.1	0.2	0.6	0.6	0.4	-0.4	-0.8	-0.0
Had major operations	0.1	0.2	0.6	0.1	0.2	0.0	0.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.1	-0.2	-0.7	-0.2	0.4
Smoking status: Previous	0.1	0.2	0.4	0.4	0.5	-0.2	0.3	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.3	0.3	0.2	0.5	0.3
Tanning	0.0	0.3	0.9	-0.2	-0.9	-0.1	0.2	-0.8
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.3	0.2	0.2	0.4	-0.3
Pulse wave reflection index	0.0	0.0	0.1	-0.2	-0.0	-0.3	-0.1	-0.2
Medication: Omeprazole	0.0	0.0	0.1	0.1	0.1	0.1	0.3	-0.1

Hub : Genes

JHDM1D

Models

Trait associations