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chr9:94,394,640-96,898,436

Best TWAS P=7.7e-23 · Best GWAS P=1.4e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	BICD2	0.06	0.02	blup	52	0.05	2.9e-06	9.0	9.8	7.7e-23	0.86	0.00	1.00	TRUE
11	GTEx	Esophagus Mucosa	CENPP	0.09	0.01	lasso	5	0.02	2.1e-02	7.5	-8.3	7.7e-17	-0.87	0.03	0.94	TRUE
26	GTEx	Whole Blood	BICD2	0.06	0.02	lasso	2	0.01	1.8e-02	7.9	7.9	2.2e-15	0.90	0.04	0.93	TRUE
46	The Cancer Genome Atlas	Thyroid Carcinoma	IPPK	0.03	0.04	blup	50	0.04	6.7e-05	8.0	-7.2	8.3e-13	-0.85	0.14	0.80	TRUE
27	GTEx	Whole Blood	RP11-165J3.6	0.10	0.07	lasso	4	0.05	1.1e-05	-6.9	-6.8	1.2e-11	0.00	0.01	0.98	TRUE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	C9orf89	0.06	0.00	blup	52	0.04	1.6e-03	4.4	-6.5	1.1e-10	-0.16	0.01	0.40	TRUE
29	METSIM	Adipose	FGD3	0.07	0.05	bslmm	460	0.05	1.3e-07	5.1	6.2	4.7e-10	0.07	1.00	0.00	TRUE
17	GTEx	Nerve Tibial	FGD3	0.41	0.22	enet	42	0.26	1.7e-18	5.1	6.0	1.6e-09	0.19	1.00	0.00	TRUE
10	GTEx	Colon Sigmoid	BICD2	0.21	0.00	lasso	6	0.06	4.6e-03	7.5	5.6	1.7e-08	0.61	0.06	0.56	TRUE
42	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IPPK	0.03	0.02	blup	51	0.01	3.2e-02	7.7	-9.5	1.4e-21	-0.89	0.04	0.54	FALSE
45	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CENPP	0.19	0.09	blup	158	0.08	7.1e-04	8.7	-9.3	1.2e-20	-0.85	0.00	0.93	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IPPK	0.06	0.03	blup	49	0.04	5.8e-03	7.9	-9.2	5.8e-20	-0.72	0.03	0.26	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BICD2	0.10	0.03	blup	52	0.03	1.3e-02	8.7	9.2	5.8e-20	0.91	0.01	0.68	FALSE
4	GTEx	Artery Aorta	ECM2	0.11	0.10	lasso	10	0.09	1.1e-05	7.6	9.0	2.0e-19	0.87	0.07	0.93	FALSE
9	GTEx	Cells Transformed fibroblasts	IPPK	0.11	0.09	lasso	8	0.07	7.8e-06	-8.0	-8.8	8.7e-19	-0.59	0.70	0.29	FALSE
7	GTEx	Brain Cerebellum	BICD2	0.23	0.06	enet	21	0.17	8.5e-06	8.7	8.7	2.3e-18	0.48	0.05	0.47	FALSE
13	GTEx	Heart Left Ventricle	ECM2	0.07	0.05	lasso	3	0.02	3.1e-02	9.0	8.6	7.8e-18	0.90	0.02	0.94	FALSE
12	GTEx	Esophagus Muscularis	BICD2	0.09	0.02	enet	26	0.07	5.0e-05	8.0	8.4	3.4e-17	0.54	0.04	0.79	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	ECM2	0.10	0.04	lasso	2	0.04	4.2e-05	7.5	8.2	3.7e-16	0.78	0.01	0.97	FALSE
6	GTEx	Brain Cerebellum	ZNF484	0.21	0.01	lasso	9	0.01	1.7e-01	8.7	8.0	1.4e-15	0.91	0.04	0.65	FALSE
23	GTEx	Spleen	BICD2	0.26	0.25	lasso	9	0.24	6.4e-07	7.9	7.9	2.6e-15	0.90	0.04	0.96	FALSE
21	GTEx	Skin Sun Exposed Lower leg	IPPK	0.17	0.07	enet	8	0.07	2.7e-06	8.0	-7.8	6.7e-15	-0.64	0.84	0.13	FALSE
16	GTEx	Nerve Tibial	ECM2	0.08	0.02	lasso	5	0.01	1.1e-01	7.5	7.3	2.8e-13	0.87	0.03	0.80	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	ECM2	0.19	0.04	enet	15	0.09	3.3e-09	7.5	7.1	1.5e-12	0.66	0.01	0.97	FALSE
5	GTEx	Brain Cerebellar Hemisphere	BICD2	0.27	0.06	lasso	9	0.04	3.9e-02	7.6	6.9	4.8e-12	0.82	0.06	0.56	FALSE
8	GTEx	Brain Cerebellum	ANKRD19P	0.22	0.00	enet	25	0.03	3.4e-02	8.6	6.5	7.8e-11	0.73	0.03	0.78	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	CENPP	0.23	0.09	lasso	11	0.07	9.6e-05	8.7	-6.4	1.5e-10	-0.82	0.04	0.95	FALSE
25	GTEx	Uterus	ZNF484	0.23	0.05	lasso	3	0.05	3.0e-02	-6.5	6.2	6.3e-10	0.21	0.08	0.08	FALSE
2	GTEx	Adipose Subcutaneous	ECM2	0.05	0.00	lasso	4	0.00	1.2e-01	-6.9	6.1	1.1e-09	0.23	0.20	0.05	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	ECM2	0.03	0.02	lasso	5	0.02	3.9e-05	-7.6	6.0	1.9e-09	0.18	0.01	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BICD2	0.06	0.04	blup	424	0.04	6.9e-06	6.9	5.9	4.4e-09	0.80	0.13	0.87	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BICD2	0.14	0.06	blup	52	0.07	5.2e-08	7.9	5.9	4.8e-09	0.59	0.98	0.02	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	CENPP	0.21	0.04	enet	16	0.10	1.9e-06	8.7	-5.8	9.1e-09	-0.63	0.01	0.97	FALSE
28	METSIM	Adipose	C9orf89	0.14	0.11	enet	27	0.12	8.3e-17	4.4	-5.7	9.9e-09	-0.11	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CENPP	0.06	0.02	blup	160	0.04	6.3e-05	8.7	-5.7	1.0e-08	-0.81	0.00	0.99	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	CENPP	0.14	0.03	blup	160	0.04	6.7e-04	8.6	-5.7	1.5e-08	-0.79	0.00	0.99	FALSE
18	GTEx	Nerve Tibial	C9orf89	0.21	0.11	lasso	6	0.08	1.4e-06	4.4	-5.6	2.5e-08	-0.13	0.97	0.00	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF484	0.04	0.00	enet	5	0.02	1.4e-03	6.3	5.6	2.7e-08	0.46	0.01	0.14	FALSE
14	GTEx	Lung	FGD3	0.23	0.11	lasso	7	0.09	1.4e-07	5.2	5.5	3.6e-08	-0.02	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	FGD3	0.16	0.12	lasso	5	0.11	4.8e-09	5.1	5.4	7.1e-08	0.00	1.00	0.00	FALSE
15	GTEx	Muscle Skeletal	FGD3	0.17	0.04	lasso	6	0.02	1.8e-03	5.1	5.4	7.9e-08	0.01	0.26	0.03	FALSE
19	GTEx	Pancreas	FGD3	0.22	0.08	lasso	4	0.10	6.1e-05	5.1	5.2	1.5e-07	-0.03	0.79	0.01	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	CENPP	0.07	0.03	lasso	5	0.06	2.1e-11	8.6	-5.2	1.9e-07	-0.82	0.00	1.00	FALSE
24	GTEx	Thyroid	FGD3	0.24	0.15	lasso	6	0.12	9.4e-10	5.1	5.2	2.0e-07	0.01	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C9orf89	0.04	0.02	lasso	4	0.03	2.5e-04	4.4	-5.2	2.1e-07	-0.15	0.06	0.26	FALSE
22	GTEx	Skin Sun Exposed Lower leg	C9orf89	0.26	0.12	enet	22	0.18	4.7e-15	4.4	-5.2	2.2e-07	-0.09	1.00	0.00	FALSE