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chr10:74,740,461-79,018,276

Best TWAS P=2.82e-13 · Best GWAS P=7.59e-11 conditioned to 0.252

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Pancreas	AGAP5	0.13	0.05	lasso	5	0.06	1.8e-03	6.1	7.3	2.8e-13	0.71	0.04	0.75	TRUE
18	ROSMAP	Brain Pre-frontal Cortex	POLR3DP1	0.03	0.00	blup	244	0.02	6.3e-04	5.4	6.1	1.1e-09	0.31	0.25	0.06	TRUE
3	GTEx	Adipose Subcutaneous	C10orf11	0.24	0.21	lasso	9	0.20	3.3e-16	5.5	-5.5	3.5e-08	-0.04	0.00	1.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ADK	0.03	0.03	lasso	3	0.04	2.6e-05	6.1	6.6	4.0e-11	0.91	0.08	0.90	FALSE
6	GTEx	Colon Transverse	ADK	0.25	0.14	lasso	9	0.12	1.6e-06	6.4	6.5	7.2e-11	0.71	0.11	0.89	FALSE
9	GTEx	Lung	ADK	0.15	0.17	lasso	5	0.17	4.8e-13	6.4	-6.5	9.8e-11	-0.96	0.06	0.94	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	ADK	0.10	0.16	lasso	6	0.15	3.7e-14	6.4	-6.4	1.8e-10	-0.98	0.05	0.95	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	AP3M1	0.02	0.01	blup	231	0.02	1.3e-03	-5.3	6.4	2.0e-10	0.74	0.06	0.41	FALSE
14	GTEx	Thyroid	ADK	0.10	0.05	lasso	3	0.05	1.6e-04	6.3	-6.3	2.3e-10	-0.97	0.05	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	VCL	0.07	0.05	lasso	4	0.06	6.0e-08	-4.3	-5.9	2.9e-09	-0.60	0.16	0.84	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AP3M1	0.11	0.09	lasso	2	0.10	6.4e-05	5.7	5.7	9.3e-09	0.75	0.03	0.88	FALSE
10	GTEx	Nerve Tibial	AP3M1	0.06	0.02	lasso	2	0.02	2.6e-02	5.1	5.6	1.6e-08	0.69	0.09	0.56	FALSE
7	GTEx	Esophagus Muscularis	VCL	0.05	0.00	lasso	3	0.00	6.8e-01	6.4	5.6	1.9e-08	0.91	0.05	0.53	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	KAT6B	0.13	0.14	lasso	7	0.15	6.5e-19	5.0	-5.5	3.8e-08	-0.15	0.97	0.03	FALSE
5	GTEx	Adrenal Gland	C10orf11	0.24	0.22	enet	21	0.18	5.8e-07	5.5	-5.5	4.1e-08	-0.05	0.00	1.00	FALSE
8	GTEx	Lung	C10orf11	0.30	0.26	lasso	5	0.24	2.0e-18	5.5	-5.4	6.3e-08	-0.04	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	ADK	0.05	0.06	enet	16	0.07	7.3e-09	6.5	-5.4	8.5e-08	-0.88	0.05	0.95	FALSE
4	GTEx	Adipose Visceral Omentum	C10orf11	0.40	0.32	enet	11	0.27	2.2e-14	5.5	-5.3	1.2e-07	-0.04	0.00	1.00	FALSE
15	METSIM	Adipose	C10orf11	0.11	0.10	enet	14	0.10	1.1e-14	5.7	-5.3	1.3e-07	-0.04	0.00	1.00	FALSE
13	GTEx	Thyroid	C10orf11	0.38	0.21	lasso	9	0.25	6.7e-19	5.7	-5.3	1.4e-07	-0.06	0.00	1.00	FALSE
12	GTEx	Pituitary	RP11-178G16.5	0.13	0.10	lasso	2	0.02	1.1e-01	5.0	-5.2	2.2e-07	-0.59	0.06	0.31	FALSE