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chr12:52,990,150-55,656,617

Best TWAS P=2.3e-71 · Best GWAS P=1.63e-215 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDE1B	0.09	0.00	bslmm	420	0.03	2.7e-04	-3.63	6.9	6.3e-12	-0.24	0.12	0.06	FALSE
2	GTEx	Adipose Subcutaneous	PDE1B	0.15	0.10	enet	8	0.11	3.5e-09	-2.73	5.3	1.1e-07	-0.26	1.00	0.00	FALSE
3	GTEx	Esophagus Muscularis	SMUG1	0.30	0.08	enet	30	0.11	3.5e-07	4.96	5.7	1.1e-08	-0.06	0.76	0.01	FALSE
4	GTEx	Liver	PDE1B	0.45	-0.01	enet	72	0.14	8.2e-05	-2.68	-8.0	1.4e-15	0.13	0.05	0.17	TRUE
5	GTEx	Lung	SMUG1	0.14	0.04	enet	21	0.08	1.6e-06	-9.01	7.3	2.1e-13	0.07	0.83	0.01	FALSE
6	GTEx	Nerve Tibial	SMUG1	0.18	0.00	enet	8	0.00	2.0e-01	-9.01	6.6	5.4e-11	-0.03	0.07	0.03	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	SMUG1	0.21	0.03	lasso	4	0.14	4.6e-08	6.02	6.6	3.4e-11	-0.03	0.43	0.05	FALSE
8	GTEx	Thyroid	RP11-834C11.4	0.19	0.10	lasso	3	0.10	5.3e-08	8.14	6.6	5.0e-11	-0.34	0.94	0.01	FALSE
9	GTEx	Whole Blood	HNRNPA1	0.10	0.00	enet	24	0.00	1.1e-01	1.86	-7.9	3.5e-15	0.24	0.06	0.10	FALSE
10	METSIM	Adipose	GTSF1	0.07	0.05	bslmm	421	0.05	1.2e-07	9.76	10.4	2.1e-25	-0.17	1.00	0.00	FALSE
11	METSIM	Adipose	RP11-834C11.11	0.07	0.00	enet	37	0.04	3.8e-06	6.02	-7.6	2.1e-14	0.06	0.30	0.03	TRUE
12	YFS	Blood	CBX5	0.02	0.01	lasso	3	0.02	2.0e-07	15.40	14.6	1.6e-48	-0.52	0.95	0.03	TRUE
13	YFS	Blood	NCKAP1L	0.04	0.01	bslmm	416	0.01	6.0e-05	-16.29	-11.8	4.0e-32	0.48	0.03	0.89	TRUE
14	YFS	Blood	NFE2	0.02	0.02	bslmm	400	0.09	1.6e-28	18.43	15.7	1.5e-55	-0.23	0.28	0.66	TRUE
15	YFS	Blood	PFDN5	0.02	0.01	bslmm	408	0.01	2.0e-03	3.99	-5.5	3.9e-08	0.05	0.03	0.40	TRUE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ12825	0.32	0.29	lasso	5	0.32	1.7e-67	9.41	7.0	2.2e-12	-0.37	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100240734	0.05	0.05	enet	9	0.05	8.4e-11	-3.03	-5.8	5.1e-09	0.43	0.44	0.56	FALSE
18	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FLJ12825	0.35	0.21	lasso	5	0.26	5.5e-13	9.41	5.7	1.2e-08	-0.38	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Glioblastoma Multiforme	SMUG1	0.14	0.00	blup	42	0.06	8.5e-03	6.74	12.7	1.1e-36	-0.34	0.01	0.20	TRUE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ12825	0.35	0.27	lasso	5	0.29	7.4e-33	9.41	6.6	3.3e-11	-0.39	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ12825	0.54	0.56	enet	12	0.57	2.5e-78	9.41	8.0	1.1e-15	-0.39	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ12825	0.52	0.36	lasso	4	0.37	2.1e-22	9.41	8.7	4.0e-18	-0.36	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMUG1	0.11	0.03	blup	42	0.05	5.0e-04	1.73	5.2	2.2e-07	0.08	0.06	0.04	TRUE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	GTSF1	0.02	0.04	lasso	8	0.03	9.5e-05	9.63	9.7	3.3e-22	-0.14	0.01	0.98	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	GTSF1	0.03	0.03	lasso	2	0.03	1.4e-04	9.63	9.6	5.7e-22	-0.14	0.01	0.98	FALSE
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FLJ12825	0.09	0.03	enet	13	0.03	4.8e-03	8.14	8.1	5.0e-16	-0.17	0.00	0.92	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMUG1	0.18	0.02	blup	42	0.06	2.1e-03	-0.68	-5.5	3.5e-08	0.33	0.10	0.05	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ12825	0.35	0.23	lasso	2	0.21	8.8e-09	9.41	8.9	6.7e-19	-0.36	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMUG1	0.10	0.05	lasso	3	0.07	9.6e-04	-9.01	6.8	1.1e-11	0.06	0.07	0.06	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	GTSF1	0.05	0.08	lasso	6	0.07	4.2e-08	5.94	7.5	6.5e-14	-0.15	0.05	0.95	TRUE
31	The Cancer Genome Atlas	Rectum Adenocarcinoma	CBX5	0.16	0.10	lasso	4	0.11	1.5e-03	15.40	17.9	2.3e-71	-0.58	0.03	0.07	TRUE
32	The Cancer Genome Atlas	Soft Tissue Sarcoma	FLJ12825	0.19	0.06	enet	7	0.11	3.9e-07	6.74	6.0	2.6e-09	-0.35	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Soft Tissue Sarcoma	NCKAP1L	0.10	0.00	blup	71	0.03	8.6e-03	-9.74	11.9	1.2e-32	-0.31	0.01	0.66	TRUE