TWAS hub - GTSF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0660	0.0207	6.9e-05	0.053	0.035	0.033	0.047	0.041	2.1e-08	4.4e-06	8.6e-06	1.2e-07	8.5e-07
2	TCGA	Brain Lower Grade Glioma	0.0217	0.0114	3.0e-03	0.037	0.020	0.032	NA	0.034	4.1e-05	2.0e-03	1.4e-04	NA	9.5e-05
3	TCGA	Lung Adenocarcinoma	0.0314	0.0160	1.6e-03	0.033	0.030	0.030	NA	0.031	7.6e-05	1.6e-04	1.7e-04	NA	1.4e-04
4	TCGA	Prostate Adenocarcinoma	0.0533	0.0206	3.4e-07	0.084	0.065	0.066	NA	0.073	4.3e-09	2.4e-07	2.0e-07	NA	4.2e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Medication: Gliclazide	7.9	9.0	11.0	2.9	2.9	2.8	3.3
Blood Platelet Count	7.6	87.8	108.2	10.4	9.7	9.6	7.5
Sensitivity / hurt feelings	7.4	12.6	14.7	-3.8	-3.7	-3.7	-3.0
Commuting to job workplace: Walk	5.0	5.4	5.9	-2.4	-2.4	-2.4	-2.0
Worrier / anxious feelings	4.2	7.9	8.7	-2.9	-3.0	-2.9	-2.4
Financial difficulties in last 2 years	3.9	5.2	5.9	-2.4	-2.3	-2.3	-2.0
Stomach or abdominal pain in last month	3.8	4.8	5.3	-2.0	-2.3	-2.3	-2.1
Ever unenthusiastic/disinterested for a whole week	3.6	4.5	4.8	-2.2	-2.1	-2.0	-2.1
Wheeze or whistling in the chest in last year	3.6	6.4	7.6	2.7	2.8	2.8	1.8
Neuroticism score	3.5	7.2	7.4	-2.7	-2.7	-2.7	-2.7
Glaucoma (self-reported)	3.5	4.1	4.7	-2.1	-1.9	-1.9	-2.2
Risk taking	3.5	5.1	5.7	-2.4	-2.2	-2.3	-2.1
Mean Putamen Volume	3.4	3.9	4.5	-2.0	-2.0	-2.1	-1.7
Pain all over the body in last month	3.3	3.5	4.5	1.7	2.1	2.1	1.5
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	4.6	2.1	2.1	2.1	1.3
Nervous feelings	3.1	5.8	6.6	-2.6	-2.5	-2.5	-2.0
Miserableness	3.1	5.4	7.9	-2.1	-2.1	-2.1	-2.8
LDL Cholesterol	3.0	4.8	5.6	2.3	2.0	2.0	2.4
Neuroticism	3.0	7.3	7.5	-2.7	-2.7	-2.7	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	3.8	1.9	1.9	1.9	1.6
Medication for hormone replacement therapy	2.9	3.2	3.9	-2.0	-2.0	-2.0	-1.1
Neuroticism (Nagel 2018)	2.8	6.7	7.4	-2.6	-2.7	-2.7	-2.3
Medication: Aspirin	2.7	3.6	4.1	1.9	2.0	2.0	1.6
Supplements: Zinc	2.6	2.8	4.4	-1.6	-1.5	-1.5	-2.1
Severe depression (siblings)	2.6	2.9	3.9	2.0	1.7	1.6	1.5
Mood swings	2.6	4.6	6.2	-1.9	-2.1	-2.1	-2.5
Mouth/teeth dental problems: Loose teeth	2.5	2.9	4.6	1.6	1.5	1.5	2.1
Multivitamins +/- minerals	2.4	3.0	5.4	-1.4	-1.5	-1.5	-2.3
Eye problems/disorders: Cataract	2.4	2.8	3.7	1.9	1.6	1.6	1.6
Medication for pain relief, constipation, heartburn	2.3	4.0	4.7	-2.2	-2.1	-2.2	-1.4
Average weekly spirits intake	2.2	2.8	3.5	1.7	1.5	1.5	1.9
Emphysema/chronic bronchitis	2.2	2.4	3.0	1.3	1.6	1.6	1.7
Ever had hysterectomy (womb removed)	2.1	2.4	2.6	-1.6	-1.6	-1.5	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	3.5	-1.8	-1.9	-1.8	-1.6
Medication: Aspirin	2.1	2.8	3.3	1.7	1.8	1.8	1.3
Cholesterol lowering medication	2.1	3.1	3.8	1.7	1.7	1.7	1.9
Medication: Atorvastatin	2.0	2.5	3.2	1.5	1.5	1.5	1.8
Guilty feelings	1.9	2.8	3.6	-1.9	-1.8	-1.8	-1.0
Happiness	1.8	2.1	2.6	1.6	1.6	1.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	5.8	-1.1	-1.1	-1.1	-2.4
Number of self-reported non-cancer illnesses	1.8	3.2	4.3	-1.7	-1.7	-1.7	-2.1
Pulse wave reflection index	1.7	2.1	2.2	-1.4	-1.5	-1.5	-1.4
Medication: Paracetamol	1.7	2.9	3.6	1.6	1.9	1.9	1.4
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	3.6	1.9	1.9	1.8	1.6
Pain type(s) experienced in last month: Hip pain	1.7	2.1	2.6	1.4	1.4	1.4	1.6
Birth weight	1.6	3.4	4.6	1.7	1.8	1.7	2.1
Qualifications: nursing, teaching	1.6	2.5	3.1	1.7	1.4	1.4	1.8
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	4.1	-1.5	-1.4	-1.4	-2.0
Triglycerides	1.5	2.4	3.5	1.4	1.5	1.5	1.9
Trunk fat percentage	1.5	6.1	7.5	2.7	2.6	2.6	1.9
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	1.9	1.2	1.4	1.4	1.1
Chronic bronchitis/emphysema (father)	1.5	1.7	2.0	1.4	1.4	1.4	1.0
Depression (self-reported)	1.5	1.8	4.2	-1.0	-1.0	-1.0	-2.1
Body fat percentage	1.5	6.0	7.3	2.7	2.6	2.6	1.9
Worry too long after embarrassment	1.5	2.5	2.8	-1.7	-1.6	-1.6	-1.4
Average weekly beer plus cider intake	1.5	2.1	2.7	1.6	1.5	1.5	1.1
Ever depressed for a whole week	1.5	1.9	2.3	-1.5	-1.4	-1.3	-1.3
Ulcerative Colitis	1.4	2.1	2.4	1.4	1.5	1.5	1.3
Hearing difficulty/problems: Yes	1.4	2.2	3.1	1.4	1.7	1.7	0.7
Vitamin and mineral supplements	1.4	1.9	3.8	1.1	1.1	1.1	1.9
Medication: Atenolol	1.4	1.7	2.3	-1.5	-1.3	-1.3	-1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	2.2	-1.3	-1.5	-1.5	-1.1
Arm fat percentage (left)	1.4	5.5	7.0	2.6	2.5	2.5	1.6
Mineral and other dietary supplements	1.4	1.9	2.6	1.3	1.3	1.3	1.6
Osteoporosis (self-reported)	1.4	1.8	2.0	1.3	1.3	1.3	1.4
Worry (Nagel 2018)	1.3	2.8	3.4	-1.8	-1.8	-1.8	-1.1
Illnesses of siblings	1.3	1.9	2.2	1.4	1.5	1.5	1.1
Impedance of arm (left)	1.3	6.1	7.9	2.8	2.3	2.4	2.3
High blood pressure (siblings)	1.3	1.9	2.3	-1.5	-1.5	-1.5	-0.9
Ever had bowel cancer screening	1.3	1.5	2.4	-1.2	-1.0	-1.1	-1.6
Vascular/heart problems diagnosed by doctor	1.3	3.5	4.2	2.1	1.7	1.7	1.9
Reaction Time	1.2	2.3	3.9	-1.2	-1.4	-1.4	-2.0
Neuroticism (2016)	1.2	1.8	4.1	-1.1	-0.9	-0.9	-2.0
Hypothyroidism (self reported)	1.2	2.8	3.4	1.8	1.8	1.8	1.1
Arm fat percentage (right)	1.2	4.7	6.1	2.5	2.4	2.4	1.3
Headache pain in last month	1.2	2.1	2.8	-1.3	-1.4	-1.4	-1.7
Migraine (self-reported)	1.2	1.5	1.8	-1.4	-1.2	-1.2	-1.1
Depressed Affect (Nagel 2018)	1.1	2.4	2.6	-1.6	-1.5	-1.6	-1.5
Alzheimer’s Disease (in mother)	1.1	1.3	1.5	1.1	1.1	1.1	1.2
Coronary Artery Disease (CAD)	1.1	1.3	2.2	-1.2	-0.9	-0.9	-1.5
Lupus	1.1	1.6	1.8	-1.3	-1.3	-1.3	-1.1
Blood Eosinophil Count	1.1	8.7	9.8	3.1	3.0	3.0	2.6
Respiratory disease	1.1	2.4	3.0	1.6	1.7	1.7	0.8
Mouth/teeth dental problems	1.1	1.7	2.2	1.2	1.2	1.2	1.5
Falls in the last year	1.1	1.5	1.7	1.2	1.3	1.3	1.1
Pulse rate	1.1	1.8	1.9	1.4	1.4	1.4	1.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.4	-1.0	-0.6	-0.6	-1.8
Leg fat percentage (right)	1.1	4.1	4.8	2.2	2.1	2.1	1.7
Long-standing illness, disability or infirmity	1.1	1.7	2.5	1.2	1.6	1.5	0.5
Heart disease (siblings)	1.1	1.3	1.9	-1.4	-1.3	-1.3	-0.4
Major Depression (MDD)	1.0	1.3	3.1	-0.9	-0.7	-0.7	-1.8
Cardiovascular Disease	1.0	3.4	4.0	-2.0	-1.7	-1.7	-2.0
Number of full brothers	1.0	1.2	1.5	-1.2	-1.1	-1.1	-1.0
Illnesses of father: Heart disease	1.0	1.4	2.2	-1.5	-1.2	-1.2	-0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.0	-0.9	-0.9	-0.9	-1.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.0	-0.3	-0.7	-0.7	1.7
Waist Hip Ratio (WHR)	0.9	4.2	8.4	2.9	1.8	1.8	1.3
Qualifications: CSEs or equivalent	0.9	1.2	1.9	-1.0	-1.0	-1.0	-1.4
Medication: Levothyroxine sodium	0.9	1.6	2.0	1.4	1.2	1.3	1.1
Medication: Ramipril	0.9	1.1	1.3	-0.9	-1.1	-1.1	-1.1
Impedance of arm (right)	0.9	4.0	5.7	2.4	1.9	2.0	1.7
Qualifications: A levels/AS levels or equivalent	0.9	2.1	4.0	1.1	1.2	1.2	2.0
Asthma	0.9	1.7	2.5	1.6	1.4	1.4	0.6
Birth weight of first child	0.9	1.7	5.1	-0.9	-0.7	-0.7	-2.3
Medication: Omeprazole	0.9	1.0	1.2	1.0	1.0	1.1	0.9
Medication: Seretide 50 evohaler	0.9	1.1	1.4	1.2	1.1	1.1	0.5
Leg fat mass (right)	0.9	3.3	3.9	2.0	2.0	2.0	1.3
Alcohol intake frequency.	0.9	2.1	7.3	-0.9	-0.5	-0.5	-2.7
Smoking status: Previous	0.9	1.3	1.4	1.1	1.1	1.1	1.2
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.1	-1.0	-0.7	-0.7	-1.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.1	-1.0	-0.8	-0.8	-1.4
Age when periods started (menarche)	0.8	1.8	2.7	1.4	1.6	1.6	0.2
High blood pressure	0.8	2.3	2.9	-1.7	-1.3	-1.3	-1.6
Supplements: Glucosamine	0.8	1.1	1.3	-0.9	-1.0	-1.0	-1.2
Trunk fat mass	0.8	3.2	3.9	2.0	1.9	1.9	1.3
Whole body fat mass	0.8	3.4	4.1	2.0	2.0	2.0	1.2
Supplements: Vitamin C	0.8	1.0	1.5	-0.9	-0.9	-0.9	-1.2
Average weekly champagne plus white wine intake	0.8	1.2	1.6	1.3	1.1	1.0	0.9
Medication: Paracetamol	0.8	1.3	1.9	1.1	1.3	1.4	0.5
Leg fat percentage (left)	0.8	2.9	3.5	1.9	1.8	1.8	1.3
Irritability	0.8	1.4	1.7	-1.1	-1.2	-1.1	-1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.1	-1.1	-0.9	-0.9	-0.8
Arm fat mass (right)	0.7	3.0	3.7	1.9	1.9	1.9	1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	0.9	-0.9	-1.0	-0.9	-0.7
Shortness of breath walking on level ground	0.7	0.9	1.1	1.0	1.1	1.0	0.5
Family relationship satisfaction	0.7	0.8	0.8	-0.9	-0.9	-0.9	-0.9
Asthma (self-reported)	0.7	1.5	2.2	1.5	1.3	1.3	0.4
Arm fat mass (left)	0.7	3.0	3.7	1.9	1.9	1.9	1.0
Alzheimer’s Disease (in father)	0.6	0.6	0.8	-0.8	-0.9	-0.9	-0.5
Lung FEV1/FVC ratio	0.6	2.9	4.4	1.1	1.7	1.7	2.1
Past tobacco smoking	0.6	1.1	1.3	-1.0	-1.2	-1.2	-1.0
Medication: Simvastatin	0.6	0.9	1.1	1.1	1.0	1.1	0.7
Alcohol intake versus 10 years previously	0.6	0.9	1.0	-1.0	-0.9	-0.9	-1.0
Father’s age at death	0.6	0.9	1.2	0.9	1.1	1.1	0.5
Neck or shoulder pain in last month	0.6	0.9	1.2	1.0	1.1	1.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-0.7	-1.1	-1.1	-0.2
Chest pain or discomfort	0.6	0.8	1.0	0.9	1.0	1.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	1.4	-1.1	-1.2	-1.2	-0.9
Mother’s age at death	0.6	0.8	0.8	-0.9	-0.8	-0.9	-0.9
Financial situation satisfaction	0.6	0.7	0.9	-0.8	-0.9	-1.0	-0.6
Illnesses of father: High blood pressure	0.6	0.7	1.1	0.8	1.0	1.0	0.3
Leg fat mass (left)	0.6	2.5	3.0	1.7	1.7	1.7	1.0
Irritable Bowel Disease (IBD)	0.5	1.1	1.5	0.9	1.0	1.1	1.2
Body mass index (BMI)	0.5	2.0	2.6	1.5	1.6	1.6	0.6
Waist circumference	0.5	1.9	3.1	1.7	1.5	1.5	0.4
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	1.0	0.8	0.8	-0.2
Diabetes (self-reported)	0.5	0.8	0.9	-0.9	-0.8	-0.8	-0.9
Time employed in main current job	0.5	0.6	0.7	-0.8	-0.8	-0.9	-0.5
Noisy workplace	0.5	0.6	2.4	-0.2	0.1	0.2	-1.6
Loud music exposure frequency	0.5	0.5	0.6	0.6	0.8	0.8	0.7
Medication: Ibuprofen	0.5	0.6	0.9	-0.3	-0.9	-0.8	-1.0
Average weekly red wine intake	0.5	0.7	1.1	0.9	0.7	0.7	1.0
Wears glasses or contact lenses	0.5	0.6	1.1	-1.1	-0.8	-0.8	-0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.8	0.9	0.8	0.8	0.3
Supplements: Calcium	0.5	0.5	0.8	-0.7	-0.9	-0.9	-0.3
Impedance of whole body	0.5	2.4	3.2	1.8	1.3	1.3	1.8
Age at First Birth	0.4	0.6	1.2	0.8	0.5	0.5	1.1
HbA1C	0.4	0.4	0.7	-0.8	-0.4	-0.4	-0.8
Heel T-Score	0.4	3.0	4.2	-1.8	-1.6	-1.5	-2.0
Relative age of first facial hair	0.4	0.8	0.9	0.8	0.9	0.9	0.9
Diabetes (father)	0.4	0.5	2.1	-0.1	-0.0	-0.1	-1.5
Serious illness, injury or assault to yourself	0.4	0.5	0.6	-0.6	-0.7	-0.7	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	-0.7	-0.6	-0.6	-1.1
Fluid intelligence score	0.4	0.9	1.1	0.9	0.9	0.9	1.1
Weight	0.4	1.8	2.4	1.4	1.5	1.5	0.6
Trunk fat-free mass	0.4	2.2	2.7	-1.6	-1.3	-1.3	-1.6
Medication: Lansoprazole	0.4	0.5	0.6	0.7	0.7	0.7	0.6
Trunk predicted mass	0.4	2.2	2.8	-1.6	-1.3	-1.3	-1.7
Length of working week for main job	0.4	0.4	1.7	-0.2	-0.1	-0.2	-1.3
Number of children fathered	0.4	0.4	0.7	-0.6	-0.5	-0.5	-0.8
Qualifications: College or University degree	0.4	1.1	2.0	0.9	1.0	1.0	1.4
Medication: Blood pressure	0.4	0.7	1.5	-0.8	-0.6	-0.6	-1.2
Mean time to correctly identify matches	0.4	0.7	1.1	-0.7	-0.8	-0.8	-1.0
Had major operations	0.4	0.5	1.8	-0.1	0.1	0.1	-1.4
Leg pain on walking	0.4	0.5	0.7	0.6	0.9	0.8	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.7	-0.4	-0.4	-0.4	-1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	0.3	0.4	0.4	1.3
Hypertension (Self-reported)	0.4	1.2	1.6	-1.3	-0.9	-0.9	-1.2
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-0.5	-0.7	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.1	0.4	0.5	0.5	1.8
Medication: Blood pressure	0.4	0.7	1.3	-1.1	-0.9	-0.9	-0.4
Unable to work because of sickness or disability	0.4	0.5	0.7	0.7	0.9	0.8	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.6	-0.5	-0.4	-0.4	-1.3
Schizophrenia (2018)	0.3	0.6	0.9	-1.0	-0.7	-0.7	-0.7
HDL Cholesterol	0.3	0.4	0.5	-0.6	-0.7	-0.7	-0.7
Blood Red Count	0.3	3.2	4.6	1.8	2.1	2.1	0.7
Blood White Count	0.3	2.0	2.7	1.6	1.6	1.6	-0.3
Systolic Blood Pressure	0.3	1.5	2.5	-1.6	-1.1	-1.1	-1.0
Number of treatments/medications taken	0.3	0.5	1.3	-0.5	-0.4	-0.4	-1.1
Medication: Metformin	0.3	0.4	1.0	0.5	0.5	0.5	1.0
Had menopause	0.3	0.4	0.9	0.4	0.5	0.5	1.0
Had other major operations	0.3	0.3	0.6	-0.6	-0.4	-0.4	-0.8
Heart attack	0.3	0.3	1.1	-0.4	-0.3	-0.3	-1.0
Allergy	0.3	0.7	0.9	-1.0	-0.9	-0.9	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	-0.6	-0.5	-0.5	-0.9
Medication: Cholesterol lowering	0.3	0.5	0.7	0.9	0.7	0.7	0.3
Tense / ‘highly strung’	0.3	0.6	0.7	-0.8	-0.8	-0.8	-0.6
Age at first live birth	0.3	0.5	0.9	-0.6	-0.6	-0.6	-0.9
Heart disease (mother)	0.3	0.3	0.4	0.4	0.6	0.6	0.6
Knee pain experienced in last month	0.3	0.5	0.8	0.6	0.9	0.9	0.2
Medication for cholesterol	0.3	0.5	0.9	0.9	0.8	0.8	-0.0
Ever taken oral contraceptive pill	0.3	0.4	0.6	0.8	0.5	0.5	0.6
Hearing aid user	0.3	0.3	0.6	0.6	0.7	0.7	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	0.9	-1.0	-0.6	-0.6	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.8	0.8	0.9	0.9	0.6
Crohns Disease (2017)	0.2	0.4	1.0	0.5	0.4	0.4	1.0
Ulcerative Colitis (UC)	0.2	0.4	0.6	0.5	0.8	0.8	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	0.4	0.5	0.5	0.9
Ovarian Cancer	0.2	0.3	0.8	0.4	0.3	0.4	0.9
BMI	0.2	1.0	1.3	1.0	1.1	1.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.7	-0.8	-0.5	-0.5	-0.3
Chronotype (morning person)	0.2	0.5	1.7	-0.3	-0.1	-0.2	-1.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	0.6	0.6	0.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	-0.5	-0.4	-0.5	-0.3
Current tobacco smoking	0.2	0.3	0.4	0.5	0.6	0.6	-0.1
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	0.4	0.4	-0.0
Fed-up feelings	0.2	0.3	0.9	-0.4	-0.3	-0.3	-0.9
Relative age voice broke	0.2	0.3	0.6	0.5	0.5	0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	0.6	0.6	0.6	0.3
High blood pressure (mother)	0.2	0.3	0.5	0.1	0.7	0.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	0.1	0.1	0.1	-1.1
Hip circumference	0.2	0.9	1.3	1.0	1.1	1.1	0.1
Hair/balding pattern: Pattern 3	0.2	0.4	1.0	0.4	0.4	0.4	1.0
Number of live births	0.2	0.3	0.5	-0.6	-0.7	-0.7	0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.3	-0.4	-0.2	-0.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	0.9	0.5	0.5	0.2
Prospective memory result	0.2	0.2	0.4	-0.3	-0.4	-0.4	-0.6
Exposure to tobacco smoke at home	0.2	0.3	0.9	0.3	0.1	0.1	-1.0
Breastfed as a baby	0.2	0.2	0.7	-0.1	-0.3	-0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	-0.6	-0.4	-0.4	-0.6
Medication: Amlodipine	0.2	0.2	0.7	0.0	0.3	0.3	0.9
Arm fat-free mass (right)	0.2	1.2	1.5	-1.2	-1.0	-1.0	-1.2
Exposure to tobacco smoke outside home	0.2	0.3	0.4	0.5	0.5	0.5	-0.6
Arm predicted mass (right)	0.2	1.0	1.3	-1.1	-0.9	-0.9	-1.2
Suffer from ‘nerves’	0.2	0.4	0.5	-0.7	-0.6	-0.5	-0.7
Whole body fat-free mass	0.2	0.9	1.7	-1.0	-0.7	-0.7	-1.3
Loneliness, isolation	0.2	0.3	0.8	-0.6	-0.4	-0.4	-0.9
Friendships satisfaction	0.2	0.2	0.5	0.4	0.3	0.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.6	0.6	0.6	-0.0
Back pain experienced in last month	0.2	0.4	1.2	-0.4	-0.3	-0.2	-1.1
Smoking status: Current	0.2	0.3	0.5	0.5	0.7	0.7	-0.1
Whole body water mass	0.2	0.9	1.7	-1.0	-0.7	-0.7	-1.3
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.0
High cholesterol (Self-reported)	0.2	0.4	0.6	0.6	0.5	0.6	0.8
Arm fat-free mass (left)	0.2	1.2	1.9	-1.2	-0.9	-0.9	-1.4
Age started oral contraceptive pill	0.2	0.2	0.6	0.4	0.2	0.2	0.8
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.7	-0.5	-0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	-0.2	-0.2	-0.2	-0.9
Arm predicted mass (left)	0.2	1.2	2.1	-1.2	-0.9	-0.9	-1.4
Depression (Nagel 2018)	0.1	0.2	0.5	-0.3	-0.1	-0.1	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	0.5	0.3	0.3	0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.4	0.4	0.3	0.4
Bipolar Disorder (2011)	0.1	0.1	0.5	0.7	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	-0.3	-0.3	-0.3	-0.7
Crohns Disease (2012)	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4
Fasting Glucose	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.0
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.1
Rheumatoid Arthritis	0.1	0.2	0.2	-0.4	-0.4	-0.4	-0.4
Smoking Status	0.1	0.3	0.4	0.4	0.6	0.7	-0.3
Tanning	0.1	1.7	2.3	1.5	1.3	1.3	1.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.4
Medication: Co-codamol	0.1	0.1	0.2	-0.1	-0.2	-0.2	-0.5
Pack years adult smoking proportion	0.1	0.1	0.4	0.2	0.2	0.2	-0.7
Impedance of leg (right)	0.1	0.6	1.6	0.7	0.3	0.4	1.3
Hand grip strength (right)	0.1	0.2	0.3	-0.3	-0.5	-0.5	-0.1
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.1	0.4	0.4	-0.1
Maternal smoking around birth	0.1	0.2	0.3	-0.4	-0.3	-0.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.3	-0.1	-0.0	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	0.5	0.5	0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	-0.1	-0.2	-0.1	-0.8
Number of incorrect matches in round	0.1	0.2	0.2	-0.5	-0.5	-0.5	-0.5
Alcohol usually taken with meals	0.1	0.2	0.6	0.3	0.3	0.3	0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.4	-0.1	-0.1	-0.7
Forced vital capacity (FVC)	0.1	0.4	1.1	0.4	0.4	0.4	1.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.8	-0.1	0.1	0.1	0.9
Lung cancer (father)	0.1	0.2	0.3	-0.6	-0.3	-0.3	-0.4
Illnesses of mother	0.1	0.1	0.2	0.0	-0.3	-0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.7	-0.5	-0.4	0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.3	-0.4	-0.4	0.7
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.6	-0.3	-0.3	0.5
Blood clot in the leg (DVT)	0.1	0.2	0.6	-0.2	-0.1	-0.1	-0.8
Gout (self-reported)	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.2	0.1	0.1	-0.5
Comparative body size at age 10	0.1	0.2	0.4	-0.4	-0.6	-0.6	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.3
Pulse wave peak to peak time	0.1	0.1	0.4	0.2	0.2	0.2	0.6
Medication: Allopurinol	0.1	0.1	0.2	0.1	0.1	0.1	0.5
Pulse rate, automated reading	0.1	0.4	0.4	0.6	0.6	0.6	-0.6
Number of full sisters	0.1	0.1	0.5	0.2	0.1	0.1	0.7
Overall health rating	0.1	0.1	0.4	0.0	0.3	0.2	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.2
Breast cancer (self-reported)	0.1	0.1	0.1	0.1	0.3	0.3	-0.3
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.1	-0.0	-0.1	-0.6
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	0.6	0.2	0.3	0.5
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.2	-0.2	-0.2	-0.4
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.1	0.4	0.4	-0.2
Medication: Lisinopril	0.1	0.2	0.3	-0.5	-0.4	-0.4	-0.4
Alcohol drinker status: Never	0.1	0.1	0.2	0.2	0.2	0.2	-0.5
Ever smoked	0.1	0.1	0.2	0.1	0.3	0.3	0.4
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.0	0.0	-0.4
Diastolic blood pressure, automated reading	0.1	0.4	0.5	-0.7	-0.7	-0.7	-0.5
Myopia	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	0.4	0.4	0.1
Pain experienced in last month	0.1	0.1	0.2	-0.2	-0.5	-0.5	-0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.6	-0.3	-0.3	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.2	0.2	0.3	0.4	0.4
Pack years of smoking	0.1	0.1	0.2	0.3	0.2	0.2	-0.4
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.1	0.1	0.2	0.3	0.3	0.2
Height	0.0	0.2	0.5	-0.7	-0.2	-0.2	-0.2
Allergy or Eczema	0.0	0.0	0.1	0.1	0.1	0.1	-0.2
Lung FVC	0.0	0.1	0.3	-0.1	-0.2	-0.1	0.5
Hair Pigment	0.0	1.4	1.8	1.3	1.3	1.3	0.7
Hand grip strength (left)	0.0	0.1	0.1	-0.3	-0.4	-0.3	-0.2
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.5	-0.2	-0.2	0.1
Angina	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.0
Diabetes (mother)	0.0	0.0	0.1	-0.1	-0.3	-0.2	0.0
Leg fat-free mass (left)	0.0	0.2	0.3	0.4	0.6	0.5	-0.3
Taking other prescription medications	0.0	0.1	0.2	0.1	-0.1	-0.1	-0.5
Sitting height	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2
Impedance of leg (left)	0.0	0.1	0.3	0.2	-0.2	-0.1	0.5
Leg predicted mass (left)	0.0	0.2	0.3	0.4	0.6	0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.3	0.2	0.2	-0.5
Qualifications: None of the above	0.0	0.1	0.3	-0.3	-0.1	-0.1	-0.5
Standing height	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.1	-0.3	-0.3	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.5	0.0	0.1	0.1	0.7
Health satisfaction	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.4
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.2	0.2	0.2	-0.2
Angina (self-reported)	0.0	0.0	0.1	-0.3	-0.2	-0.2	-0.1
Comparative height size at age 10	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1
Age at last live birth	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	0.1	0.1	0.2
Leg fat-free mass (right)	0.0	0.2	0.7	-0.1	0.1	0.1	-0.8
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.0	0.2	0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.4
Leg predicted mass (right)	0.0	0.2	0.7	-0.1	0.1	0.1	-0.8
Basal metabolic rate	0.0	0.2	0.7	-0.4	-0.1	-0.1	-0.9
Fractured/broken bones in last 5 years	0.0	0.0	0.1	-0.4	-0.2	-0.1	-0.1

Hub : Genes

GTSF1

Models

Trait associations