Hub : Genes

NCKAP1L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Vagina	0.7530	0.0810	0.00042	0.116	NA	-0.013	NA	-0.010	0.0014	NA	0.83000	NA	0.620
2	YFS	Blood	0.0379	0.0133	0.00015	0.006	0.012	0.009	0.012	0.001	0.0041	6.2e-05	0.00035	5.9e-05	0.092
3	TCGA	Soft Tissue Sarcoma	0.0950	0.0430	0.00650	0.004	0.028	0.002	NA	0.002	0.1700	8.6e-03	0.23000	NA	0.240

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.9	1.4	1.2	0.8	-0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	0.6	1.5	-0.1
Depressed Affect (Nagel 2018)	0.9	1.9	4.7	-0.4	2.2	-0.9
Depression (Nagel 2018)	0.9	1.4	3.4	-0.1	1.8	-0.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	-1.1	-0.3	1.3
Neuroticism (Nagel 2018)	1.5	3.4	7.7	0.4	2.8	-1.6
Schizophrenia (2018)	0.3	0.6	1.7	0.1	1.3	0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	-0.8	1.0	0.1
Worry (Nagel 2018)	0.4	0.9	1.7	-0.2	1.3	-1.0
Alzheimer’s Disease (in mother)	2.6	3.0	7.7	-0.1	-2.8	1.2
Alzheimer’s Disease (in father)	1.3	1.4	3.5	-0.7	-1.9	-0.4
Alzheimer’s Disease (including proxy)	3.4	4.9	14.4	-0.4	-3.8	0.3
Crohns Disease (2017)	0.5	1.2	3.3	1.8	0.5	-0.2
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	1.1	0.1	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.6	-0.0	-0.2	-0.8
Major Depression (MDD)	1.0	1.2	2.2	-0.2	1.5	-1.1
Reaction Time	2.1	4.0	11.0	0.8	0.6	-3.3
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.3	0.0	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.4	0.5	0.9	-1.0	-0.7	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	1.5	-0.0	0.4	1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.2	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.0	-0.2	-0.8
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.4	-0.6	0.3
Crohns Disease (2012)	0.2	0.3	0.6	0.2	0.8	-0.6
Mean Putamen Volume	1.6	1.8	5.1	0.4	0.2	-2.3
Fasting Glucose	0.1	0.1	0.2	0.4	0.1	0.2
HbA1C	0.3	0.4	0.6	-0.5	0.6	-0.8
HDL Cholesterol	0.7	1.1	2.0	-1.0	0.6	1.4
LDL Cholesterol	0.2	0.3	0.6	0.4	0.8	0.4
Lupus	0.2	0.4	0.8	0.6	0.0	-0.9
Neuroticism (2016)	0.9	1.3	1.7	0.9	1.3	-1.2
Primary Biliary Cirrhosis	0.5	0.7	1.7	0.5	1.3	-0.2
Rheumatoid Arthritis	0.5	0.7	1.9	0.1	1.4	-0.1
Schizophrenia (2014)	0.5	1.2	2.5	0.2	1.6	1.0
Triglycerides	0.5	0.8	0.9	0.8	-0.9	-0.9
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.6	0.1	-0.1
Ulcerative Colitis	0.1	0.1	0.2	-0.4	-0.2	-0.2
Blood Eosinophil Count	0.8	6.3	12.2	1.4	-2.2	3.5
Blood Platelet Count	8.1	93.8	141.6	0.7	-11.8	11.9
Blood Red Count	0.4	4.1	5.1	-2.2	-2.1	1.7
Blood White Count	0.0	0.2	0.3	0.1	0.6	0.6
Heel T-Score	0.1	0.7	1.6	-0.7	-1.3	-0.1
BMI	0.3	1.9	4.2	-2.1	-1.0	0.6
Height	0.1	1.9	3.4	1.8	1.5	0.3
Waist Hip Ratio (WHR)	1.2	5.6	6.8	-2.4	-2.1	2.6
Systolic Blood Pressure	0.5	2.6	7.2	0.5	2.7	-0.6
Smoking Status	0.1	0.2	0.5	0.3	0.7	0.2
Allergy or Eczema	0.1	0.3	0.5	-0.5	-0.7	-0.2
Cardiovascular Disease	1.7	5.6	11.2	-1.2	3.3	-2.1
Hypothyroidism (self reported)	0.5	1.2	1.8	0.5	-1.4	1.2
Respiratory disease	0.3	0.7	2.0	-1.4	-0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.5	1.6	-0.1	0.0
Lung FEV1/FVC ratio	0.1	0.7	1.2	-1.0	1.1	0.3
Lung FVC	0.3	1.7	2.9	0.7	-1.7	1.3
Neuroticism	1.1	2.6	6.7	-0.4	2.6	-1.0
Chronotype (morning person)	0.0	0.1	0.3	-0.1	0.0	-0.5
Hair Pigment	0.1	2.3	4.9	0.1	-2.2	1.4
Tanning	0.1	0.9	2.5	-1.6	-0.1	-0.4
Hand grip strength (left)	0.1	0.2	0.3	-0.3	-0.5	0.3
Number of treatments/medications taken	1.3	2.4	4.2	-2.0	1.5	-0.8
Average weekly spirits intake	1.5	1.9	4.3	-0.0	-1.2	2.1
Sensitivity / hurt feelings	0.8	1.3	3.8	0.3	0.3	-1.9
Frequency of depressed mood in last 2 weeks	2.1	3.0	5.6	-2.4	1.5	-1.1
Hearing difficulty/problems: Yes	1.9	2.9	8.7	0.2	3.0	-0.2
Relative age of first facial hair	0.4	0.9	2.5	-0.5	0.0	1.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.8	0.8	-0.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.7	1.3	0.1	-1.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	-0.5	0.4	-1.4
Systolic blood pressure, automated reading	0.5	1.3	2.3	1.5	1.3	-0.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.0	1.1	-1.4	1.2
Angina	0.2	0.2	0.4	-0.6	0.5	-0.0
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	-0.4	0.0
Vitamin and mineral supplements	1.1	1.5	3.5	1.9	-0.0	1.0
Supplements: Zinc	2.5	2.7	3.9	-2.0	1.2	-1.6
Medication: Co-codamol	0.2	0.3	0.4	-0.6	-0.2	0.6
Medication: Metformin	0.2	0.3	0.4	0.5	0.4	0.7
Diabetes (father)	0.4	0.5	0.7	-0.8	0.7	-0.7
Diabetes (mother)	0.4	0.5	1.2	-0.3	1.1	0.4
Severe depression (siblings)	1.5	1.7	2.8	-1.1	-1.1	1.7
Pack years adult smoking proportion	1.1	1.7	2.5	1.6	0.6	-1.5
Impedance of leg (right)	0.4	2.0	2.3	1.5	-1.4	1.3
Leg fat-free mass (left)	0.2	0.8	2.5	-1.6	0.0	-0.1
Trunk fat percentage	0.8	3.4	4.7	-1.8	-1.5	2.2
Hand grip strength (right)	0.3	0.8	2.0	-0.3	-1.4	0.5
Townsend deprivation index at recruitment	0.7	1.0	1.2	0.8	1.0	-1.1
Current tobacco smoking	0.4	0.7	1.9	0.4	0.1	-1.4
Average weekly fortified wine intake	0.2	0.3	0.5	0.1	0.6	0.7
Maternal smoking around birth	1.2	1.7	4.2	-0.7	2.1	-0.6
Fed-up feelings	1.0	1.9	3.0	-1.6	1.7	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.0	-0.6	2.0	-1.1
Relative age voice broke	0.0	0.1	0.1	-0.2	0.2	0.3
Taking other prescription medications	0.1	0.2	0.6	-0.1	0.1	-0.8
Age when periods started (menarche)	0.1	0.3	0.8	-0.9	-0.1	0.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.3	-1.5	-0.8	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	-0.8	-0.7	-0.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.4	0.2	0.4	1.6
Qualifications: CSEs or equivalent	0.6	0.7	1.2	-1.1	1.0	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	1.3	-1.1	-0.1	-0.3
High blood pressure	1.5	4.1	10.4	-0.7	3.2	-1.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.5	-1.9	-0.7	0.4
Multivitamins +/- minerals	2.4	3.0	5.8	-2.4	-0.7	-1.7
Stomach or abdominal pain in last month	1.4	1.8	3.6	0.9	0.9	-1.9
Supplements: Glucosamine	1.2	1.5	3.5	-0.1	1.0	-1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.2	0.9	0.3
Medication: Atenolol	2.1	2.7	4.0	1.7	1.0	-2.0
Medication: Levothyroxine sodium	0.6	1.0	2.4	1.6	-0.7	0.2
Sitting height	0.1	0.5	1.4	0.1	-1.2	0.3
Chronic bronchitis/emphysema (father)	0.6	0.8	1.6	-0.2	-0.8	1.3
High blood pressure (mother)	2.8	4.0	9.5	1.5	3.1	0.2
Body mass index (BMI)	0.3	1.5	3.9	-2.0	-0.2	0.7
Impedance of leg (left)	0.3	1.5	2.2	1.5	-1.1	1.1
Leg predicted mass (left)	0.2	0.9	2.6	-1.6	-0.0	-0.1
Trunk fat mass	0.6	2.5	3.4	-1.8	-1.4	1.5
Waist circumference	0.5	2.0	4.5	-2.1	-0.8	0.9
Number of incorrect matches in round	0.9	1.4	4.1	-0.2	0.4	-2.0
Past tobacco smoking	0.3	0.5	0.6	-0.8	0.5	-0.8
Alcohol usually taken with meals	0.8	1.2	1.9	-1.3	-1.4	-0.2
Nervous feelings	1.4	2.6	3.3	-1.3	1.7	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	0.1	0.8	-1.0
Hearing difficulty/problems with background noise	0.9	1.5	4.1	-0.6	2.0	-0.2
Hair/balding pattern: Pattern 2	1.1	1.4	4.1	-2.0	-0.2	-0.0
Had menopause	0.5	0.7	1.0	0.7	1.0	-0.7
Had other major operations	0.6	0.8	1.5	-0.5	1.2	0.8
Forced vital capacity (FVC)	0.7	2.8	4.8	1.1	-2.2	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.5	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.8	-0.5	0.5	-1.4
Qualifications: None of the above	0.5	1.0	1.9	0.9	0.6	-1.4
Financial difficulties in last 2 years	1.0	1.4	1.7	-1.2	1.3	-1.0
Mouth/teeth dental problems	2.1	3.2	8.2	-0.1	-2.9	1.2
Heart attack	0.3	0.4	0.7	0.0	0.7	-0.9
Allergy	0.9	2.1	5.1	2.3	1.0	-0.4
Pain all over the body in last month	1.0	1.1	1.8	0.5	-1.3	1.1
Diabetes (self-reported)	0.2	0.3	0.8	0.9	-0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	0.9	-0.9	-0.9	-0.5
Medication: Ramipril	2.0	2.5	3.7	0.7	1.9	-1.8
Medication: Simvastatin	0.1	0.2	0.6	-0.1	0.0	-0.7
Fluid intelligence score	0.4	0.9	2.2	0.7	-0.1	1.5
Illnesses of siblings	0.3	0.4	1.1	-1.0	0.3	0.3
Neuroticism score	1.1	2.2	3.4	-1.1	1.8	-1.4
Weight	0.2	1.2	2.6	-1.6	-0.6	0.8
Impedance of arm (right)	0.8	3.6	5.6	0.4	-2.2	2.4
Arm fat percentage (right)	0.9	3.5	6.5	-2.5	-1.1	1.7
Trunk fat-free mass	0.3	1.8	4.0	-0.5	1.1	-2.0
Hip circumference	0.1	0.4	0.8	-0.9	-0.6	0.4
Time employed in main current job	0.1	0.1	0.2	-0.2	0.5	-0.0
Alcohol intake versus 10 years previously	4.1	6.1	8.6	-1.9	2.9	-2.4
Father’s age at death	0.3	0.4	1.1	-0.3	1.0	-0.3
Worrier / anxious feelings	1.1	2.0	2.4	-1.5	1.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	5.2	-2.1	2.3	-0.3
Falls in the last year	1.1	1.5	3.9	0.8	-2.0	0.0
Hair/balding pattern: Pattern 3	0.7	1.1	1.9	1.0	1.4	0.6
Number of live births	0.3	0.5	1.2	1.1	0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.0	-0.1	-1.7	1.3
Pulse rate	0.6	1.1	2.7	0.4	0.6	1.6
Happiness	0.3	0.4	0.7	-0.8	0.1	0.7
Noisy workplace	0.7	0.9	1.4	0.5	1.2	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.8	-0.7	-1.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.2	-1.1	-0.2	0.3
Mouth/teeth dental problems: Dentures	0.8	1.4	2.2	0.5	1.5	-1.3
Asthma	0.3	0.6	0.8	-0.5	-0.9	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	0.1	1.2	1.2
Medication: Cholesterol lowering	0.1	0.2	0.3	-0.3	-0.6	-0.3
Depression (self-reported)	0.6	0.7	1.0	0.6	-0.9	-1.0
Medication: Lansoprazole	1.5	1.7	4.7	2.2	0.2	0.5
Prospective memory result	0.9	1.1	1.6	-0.7	1.3	-1.1
Lung cancer (father)	0.2	0.2	0.5	0.3	-0.7	-0.1
Illnesses of mother	2.4	2.9	5.3	-1.8	-2.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	-1.0	-0.6	0.9
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.5	1.0	-0.5
Impedance of arm (left)	1.0	4.6	9.1	0.3	-2.1	3.0
Arm fat mass (right)	0.6	2.3	5.0	-2.2	-0.8	1.1
Trunk predicted mass	0.3	1.8	4.0	-0.5	1.0	-2.0
Standing height	0.0	0.3	0.6	0.6	-0.8	0.0
Length of working week for main job	0.4	0.5	0.6	-0.8	-0.7	0.6
Exposure to tobacco smoke at home	0.5	0.6	1.3	0.2	1.1	-0.7
Breastfed as a baby	0.2	0.2	0.5	0.1	-0.4	-0.7
Tense / ‘highly strung’	0.1	0.2	0.4	-0.6	-0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	-0.3	-0.8	-0.6
Hair/balding pattern: Pattern 4	0.7	1.7	3.5	0.5	-1.9	1.1
Birth weight of first child	0.6	1.1	1.7	0.7	1.1	-1.3
Peak expiratory flow (PEF)	0.1	0.2	0.7	-0.2	-0.8	0.1
Pulse wave reflection index	0.7	0.9	1.5	-1.0	0.4	-1.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.1	0.3	-0.4
Loud music exposure frequency	0.1	0.2	0.4	0.1	0.1	-0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	-0.4	-0.9	0.3
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.5	-1.0	2.3	-0.7
Blood clot in the leg (DVT)	3.7	4.8	7.8	-2.1	1.5	-2.8
Medication: Paracetamol	1.2	2.1	3.1	-1.7	0.1	1.8
Headache pain in last month	0.3	0.5	1.2	-0.5	1.1	-0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	0.9	0.5	0.8
Glaucoma (self-reported)	1.3	1.5	4.5	-0.3	-0.1	-2.1
Gout (self-reported)	0.7	0.9	1.3	-1.0	1.2	0.7
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.3	1.1	-0.7	0.9
Medication: Amlodipine	0.2	0.3	0.5	0.3	0.7	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	0.3	-0.6	-1.1
Birth weight	0.5	1.1	2.4	1.6	-0.2	0.8
Chronic bronchitis/emphysema (mother)	1.6	1.9	4.8	-2.2	0.3	-0.8
High blood pressure (siblings)	0.1	0.1	0.3	-0.1	0.0	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	1.7	0.3	-1.3	1.1
Body fat percentage	0.9	3.5	4.6	-2.1	-1.4	2.0
Leg fat percentage (right)	0.6	2.3	4.2	-2.1	-1.0	1.2
Arm fat-free mass (right)	0.2	1.0	2.0	-0.7	0.7	-1.4
Exposure to tobacco smoke outside home	1.0	1.3	2.4	-1.2	1.6	-0.5
Comparative body size at age 10	0.1	0.3	0.8	-0.3	0.3	-0.9
Number of full brothers	1.5	1.9	3.0	-0.6	1.7	-1.5
Worry too long after embarrassment	0.4	0.7	1.5	0.4	1.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.8	0.2	-0.2
Wheeze or whistling in the chest in last year	0.8	1.3	2.2	0.6	-1.2	1.5
Number of children fathered	1.2	1.3	2.0	-1.4	0.0	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	-0.1	-0.6	1.4
Age at first live birth	0.1	0.1	0.2	0.4	-0.2	0.5
Pulse wave peak to peak time	0.5	0.6	1.1	0.6	-1.1	0.5
Health satisfaction	0.5	0.6	1.6	-1.3	-0.1	-0.5
Shortness of breath walking on level ground	0.9	1.0	1.7	-1.3	-1.1	0.4
Qualifications: College or University degree	0.9	2.8	6.1	0.6	-1.4	2.5
Eye problems/disorders: None of the above	2.3	2.7	7.6	0.4	2.8	-0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.1	0.8	0.4
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.7	0.4	0.2
Medication for pain relief, constipation, heartburn	0.9	1.5	3.2	1.0	0.6	-1.8
Neck or shoulder pain in last month	0.4	0.6	1.7	0.1	-0.2	1.3
Medication: Blood pressure	0.5	0.9	1.6	-1.0	0.5	-1.3
Angina (self-reported)	0.3	0.3	0.6	-0.8	0.7	0.0
Migraine (self-reported)	1.9	2.3	3.6	-1.9	-1.0	-1.5
Medication: Ibuprofen	0.9	1.1	3.3	0.3	1.8	0.2
Medication: Allopurinol	1.0	1.3	3.0	-1.7	-0.2	0.9
Medication: Omeprazole	3.2	3.8	8.7	-0.6	-3.0	1.5
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.9	-0.5	0.3
Mean time to correctly identify matches	2.0	3.9	9.4	1.5	-0.1	-3.1
Heart disease (mother)	1.0	1.3	2.8	1.7	1.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	0.2	-0.8	-0.5
Whole body fat mass	0.5	2.2	3.8	-1.9	-1.2	1.2
Leg fat mass (right)	0.4	1.5	2.8	-1.7	-0.9	1.0
Arm predicted mass (right)	0.2	0.8	1.7	-0.6	0.7	-1.3
Pulse rate, automated reading	0.4	1.3	1.6	-0.8	1.3	1.3
Alcohol intake frequency.	3.2	7.4	11.0	-3.3	1.8	-2.8
Comparative height size at age 10	0.1	0.7	1.3	1.0	-0.0	-1.1
Number of full sisters	0.4	0.5	0.8	-0.7	-0.3	0.9
Suffer from ‘nerves’	1.8	2.9	7.3	-2.7	0.2	-1.1
Overall health rating	1.1	2.3	5.1	-2.3	1.4	-0.1
Chest pain or discomfort	1.0	1.5	2.5	1.2	-1.6	0.7
Had major operations	0.3	0.3	0.4	0.6	0.5	-0.5
Age at last live birth	0.5	0.7	1.9	0.2	-0.4	1.4
Family relationship satisfaction	0.9	1.1	1.7	-1.3	0.7	-1.1
Leg pain on walking	1.0	1.2	3.6	0.2	1.9	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	-1.5	-0.6	0.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	1.2	-0.8	0.2
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	4.6	2.1	-0.9	0.8
Medication: Aspirin	0.6	0.8	1.0	-1.0	-1.0	0.8
Supplements: Vitamin C	0.5	0.6	1.2	-1.1	0.5	-0.5
Knee pain experienced in last month	0.3	0.4	0.8	0.5	0.9	-0.6
Hypertension (Self-reported)	1.4	3.9	9.8	-0.7	3.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.3	0.8	-0.8	2.3
Illnesses of father: Heart disease	0.4	0.5	1.4	1.2	0.2	0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.1	-0.3	0.6
Smoking status: Previous	0.6	0.9	2.4	0.3	-0.5	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	1.0	0.7	-0.2
Whole body fat-free mass	0.2	1.1	2.0	-0.9	0.7	-1.4
Leg fat-free mass (right)	0.1	0.8	2.1	-1.4	0.3	-0.5
Arm fat percentage (left)	1.0	3.9	6.3	-2.5	-1.1	2.0
Average weekly red wine intake	1.1	1.7	3.0	0.2	-1.4	1.7
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.4	0.6	0.1
Mood swings	0.9	1.6	2.7	-1.6	0.9	-1.1
Loneliness, isolation	1.2	1.7	4.1	0.9	2.0	-0.2
Long-standing illness, disability or infirmity	1.0	1.6	3.7	-1.9	0.7	-0.7
Ever had bowel cancer screening	1.3	1.5	2.7	0.4	1.7	-1.2
Diabetes diagnosed by doctor	0.5	0.8	2.1	1.5	-0.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.1	0.5	-0.2
Friendships satisfaction	0.5	0.6	1.3	-0.5	-0.5	1.1
Qualifications: nursing, teaching	1.7	2.6	3.5	1.3	-1.9	1.6
Commuting to job workplace: Walk	1.8	1.9	2.9	-0.8	1.7	-1.5
Eye problems/disorders: Cataract	4.2	4.9	11.7	1.0	-3.4	1.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.2	0.5	1.5	-0.5
Medication for cholesterol	1.3	2.0	3.2	1.0	-1.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	6.2	0.3	-2.5	0.0
Back pain experienced in last month	0.9	1.4	3.7	-1.9	0.3	-0.6
Mineral and other dietary supplements	0.2	0.2	0.7	0.2	-0.1	0.8
Breast cancer (self-reported)	1.1	1.3	2.1	0.9	1.5	0.9
Asthma (self-reported)	0.3	0.6	0.8	-0.6	-0.9	0.7
Osteoporosis (self-reported)	0.8	1.0	2.6	1.6	-0.1	0.7
Osteoarthritis (self-reported)	0.6	0.8	1.2	-0.1	1.1	-1.1
Medication: Aspirin	0.6	0.8	1.0	-1.0	-1.0	0.7
Medication: Gliclazide	2.8	3.2	6.5	-0.7	-1.6	2.5
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.3	-0.2	0.1
Smoking status: Current	0.4	0.6	1.7	0.4	-0.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	4.9	-2.2	-0.9	1.5
Whole body water mass	0.2	1.0	1.7	-0.9	0.7	-1.3
Leg predicted mass (right)	0.2	0.8	2.2	-1.5	0.3	-0.5
Arm fat mass (left)	0.6	2.5	5.1	-2.3	-0.8	1.4
Number of self-reported non-cancer illnesses	2.4	4.2	7.4	-1.6	1.7	-2.7
Average weekly champagne plus white wine intake	0.4	0.6	1.0	0.6	-0.6	1.0
Miserableness	1.2	2.1	3.6	0.4	1.6	-1.9
Guilty feelings	1.5	2.2	4.6	1.2	2.1	-0.8
Wears glasses or contact lenses	0.0	0.1	0.1	0.3	0.1	-0.3
Ever taken oral contraceptive pill	2.6	2.9	3.6	1.4	-1.9	1.8
Hearing aid user	1.0	1.1	3.0	-0.5	1.7	0.2
Mother’s age at death	0.6	0.8	1.6	0.8	0.3	-1.3
Financial situation satisfaction	0.4	0.5	0.9	-1.0	-0.4	-0.5
Tinnitus: Yes, now most or all of the time	1.9	2.2	2.7	1.5	1.6	-1.3
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.5	-0.1	0.2
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	-1.3	-0.1	-0.7
Medication: Blood pressure	1.0	2.0	4.9	-0.8	2.2	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	0.5	0.8	1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.1	-0.8	0.7	-1.1
High cholesterol (Self-reported)	0.0	0.1	0.1	0.1	0.2	-0.4
Medication: Bendroflumethiazide	1.3	1.9	3.0	-1.7	1.6	0.4
Medication: Paracetamol	1.3	2.0	4.2	-2.1	0.8	1.1
Medication: Lisinopril	0.9	1.2	2.0	-0.7	1.0	-1.4
Medication: Atorvastatin	0.8	1.0	1.6	-0.6	-1.0	1.3
Illnesses of father: High blood pressure	1.0	1.2	3.2	-1.8	0.6	-0.1
Alcohol drinker status: Never	0.8	0.9	2.0	-1.4	0.8	0.4
Ever smoked	0.3	0.4	0.9	1.0	0.6	-0.1
Basal metabolic rate	0.2	0.9	1.9	-1.4	0.3	-0.8
Leg fat percentage (left)	0.6	2.2	4.7	-2.2	-0.7	1.1
Arm fat-free mass (left)	0.3	1.4	2.6	-0.8	0.9	-1.6
Number of operations (self-reported)	0.6	0.9	2.7	0.1	1.6	0.0
Average weekly beer plus cider intake	0.5	0.8	2.2	0.0	-1.5	0.2
Irritability	0.8	1.4	2.6	-1.1	1.6	-0.6
Risk taking	0.9	1.3	2.1	0.0	1.3	-1.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.8	-0.2	0.6
Fractured/broken bones in last 5 years	2.7	3.5	4.5	2.1	1.7	-1.7
Age started oral contraceptive pill	1.1	1.3	4.0	2.0	0.1	0.0
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	-0.0	-0.6
Ever depressed for a whole week	0.8	0.9	2.0	-0.2	0.9	-1.4
Unable to work because of sickness or disability	0.7	0.9	1.7	1.3	-0.9	0.5
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.1	-0.3	-0.1
Myopia	0.5	0.7	1.5	0.0	1.2	-0.8
Vascular/heart problems diagnosed by doctor	1.7	4.5	9.6	1.2	-3.1	1.6
Cholesterol lowering medication	0.2	0.2	0.3	-0.6	0.3	0.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.9	-1.0	-2.4	0.3
Pain experienced in last month	0.9	1.6	3.7	1.0	-1.9	-0.3
Supplements: Calcium	0.8	0.8	2.0	1.4	0.6	-0.4
Basal cell carcinoma (self-reported)	1.5	1.8	3.7	1.9	-0.1	-1.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	0.1	0.8	-0.9
Deep venous thrombosis (DVT) (self-reported)	3.8	4.8	7.6	-2.2	1.4	-2.8
Heart disease (siblings)	1.5	1.9	3.9	2.0	0.3	-1.2
Alcohol drinker status: Previous	0.6	0.7	2.2	0.0	-0.0	-1.5
Pack years of smoking	1.2	1.8	2.5	1.6	0.8	-1.5
Impedance of whole body	0.6	3.1	5.1	0.9	-1.8	2.3
Leg fat mass (left)	0.4	1.6	3.1	-1.8	-0.8	1.0
Arm predicted mass (left)	0.2	1.2	2.2	-0.7	0.9	-1.5