TWAS hub - NCKAP1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Vagina	0.7530	0.0810	0.00042	0.116	NA	-0.013	NA	-0.010	0.0014	NA	0.83000	NA	0.620
2	YFS	Blood	0.0379	0.0133	0.00015	0.006	0.012	0.009	0.012	0.001	0.0041	6.2e-05	0.00035	5.9e-05	0.092
3	TCGA	Soft Tissue Sarcoma	0.0950	0.0430	0.00650	0.004	0.028	0.002	NA	0.002	0.1700	8.6e-03	0.23000	NA	0.240

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	8.1	93.8	141.6	0.7	-11.8	11.9
Eye problems/disorders: Cataract	4.2	4.9	11.7	1.0	-3.4	1.4
Alcohol intake versus 10 years previously	4.1	6.1	8.6	-1.9	2.9	-2.4
Deep venous thrombosis (DVT) (self-reported)	3.8	4.8	7.6	-2.2	1.4	-2.8
Blood clot in the leg (DVT)	3.7	4.8	7.8	-2.1	1.5	-2.8
Alzheimer’s Disease (including proxy)	3.4	4.9	14.4	-0.4	-3.8	0.3
Medication: Omeprazole	3.2	3.8	8.7	-0.6	-3.0	1.5
Alcohol intake frequency.	3.2	7.4	11.0	-3.3	1.8	-2.8
High blood pressure (mother)	2.8	4.0	9.5	1.5	3.1	0.2
Medication: Gliclazide	2.8	3.2	6.5	-0.7	-1.6	2.5
Fractured/broken bones in last 5 years	2.7	3.5	4.5	2.1	1.7	-1.7
Alzheimer’s Disease (in mother)	2.6	3.0	7.7	-0.1	-2.8	1.2
Ever taken oral contraceptive pill	2.6	2.9	3.6	1.4	-1.9	1.8
Supplements: Zinc	2.5	2.7	3.9	-2.0	1.2	-1.6
Multivitamins +/- minerals	2.4	3.0	5.8	-2.4	-0.7	-1.7
Illnesses of mother	2.4	2.9	5.3	-1.8	-2.3	0.6
Number of self-reported non-cancer illnesses	2.4	4.2	7.4	-1.6	1.7	-2.7
Eye problems/disorders: None of the above	2.3	2.7	7.6	0.4	2.8	-0.5
Reaction Time	2.1	4.0	11.0	0.8	0.6	-3.3
Frequency of depressed mood in last 2 weeks	2.1	3.0	5.6	-2.4	1.5	-1.1
Medication: Atenolol	2.1	2.7	4.0	1.7	1.0	-2.0
Mouth/teeth dental problems	2.1	3.2	8.2	-0.1	-2.9	1.2
Medication: Ramipril	2.0	2.5	3.7	0.7	1.9	-1.8
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	5.2	-2.1	2.3	-0.3
Mean time to correctly identify matches	2.0	3.9	9.4	1.5	-0.1	-3.1
Hearing difficulty/problems: Yes	1.9	2.9	8.7	0.2	3.0	-0.2
Migraine (self-reported)	1.9	2.3	3.6	-1.9	-1.0	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.3	0.8	-0.8	2.3
Tinnitus: Yes, now most or all of the time	1.9	2.2	2.7	1.5	1.6	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.9	-1.0	-2.4	0.3
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.5	-1.0	2.3	-0.7
Suffer from ‘nerves’	1.8	2.9	7.3	-2.7	0.2	-1.1
Commuting to job workplace: Walk	1.8	1.9	2.9	-0.8	1.7	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	6.2	0.3	-2.5	0.0
Cardiovascular Disease	1.7	5.6	11.2	-1.2	3.3	-2.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	4.6	2.1	-0.9	0.8
Qualifications: nursing, teaching	1.7	2.6	3.5	1.3	-1.9	1.6
Vascular/heart problems diagnosed by doctor	1.7	4.5	9.6	1.2	-3.1	1.6
Mean Putamen Volume	1.6	1.8	5.1	0.4	0.2	-2.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	4.8	-2.2	0.3	-0.8
Neuroticism (Nagel 2018)	1.5	3.4	7.7	0.4	2.8	-1.6
Average weekly spirits intake	1.5	1.9	4.3	-0.0	-1.2	2.1
Severe depression (siblings)	1.5	1.7	2.8	-1.1	-1.1	1.7
High blood pressure	1.5	4.1	10.4	-0.7	3.2	-1.2
Medication: Lansoprazole	1.5	1.7	4.7	2.2	0.2	0.5
Number of full brothers	1.5	1.9	3.0	-0.6	1.7	-1.5
Guilty feelings	1.5	2.2	4.6	1.2	2.1	-0.8
Basal cell carcinoma (self-reported)	1.5	1.8	3.7	1.9	-0.1	-1.2
Heart disease (siblings)	1.5	1.9	3.9	2.0	0.3	-1.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.0	1.1	-1.4	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.0	-0.6	2.0	-1.1
Stomach or abdominal pain in last month	1.4	1.8	3.6	0.9	0.9	-1.9
Nervous feelings	1.4	2.6	3.3	-1.3	1.7	-1.8
Hypertension (Self-reported)	1.4	3.9	9.8	-0.7	3.1	-1.2
Alzheimer’s Disease (in father)	1.3	1.4	3.5	-0.7	-1.9	-0.4
Number of treatments/medications taken	1.3	2.4	4.2	-2.0	1.5	-0.8
Glaucoma (self-reported)	1.3	1.5	4.5	-0.3	-0.1	-2.1
Ever had bowel cancer screening	1.3	1.5	2.7	0.4	1.7	-1.2
Medication for cholesterol	1.3	2.0	3.2	1.0	-1.8	1.3
Medication: Bendroflumethiazide	1.3	1.9	3.0	-1.7	1.6	0.4
Medication: Paracetamol	1.3	2.0	4.2	-2.1	0.8	1.1
Waist Hip Ratio (WHR)	1.2	5.6	6.8	-2.4	-2.1	2.6
Maternal smoking around birth	1.2	1.7	4.2	-0.7	2.1	-0.6
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.3	-1.5	-0.8	-1.2
Supplements: Glucosamine	1.2	1.5	3.5	-0.1	1.0	-1.9
Medication: Paracetamol	1.2	2.1	3.1	-1.7	0.1	1.8
Number of children fathered	1.2	1.3	2.0	-1.4	0.0	-1.4
Loneliness, isolation	1.2	1.7	4.1	0.9	2.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	4.9	-2.2	-0.9	1.5
Miserableness	1.2	2.1	3.6	0.4	1.6	-1.9
Pack years of smoking	1.2	1.8	2.5	1.6	0.8	-1.5
Neuroticism	1.1	2.6	6.7	-0.4	2.6	-1.0
Vitamin and mineral supplements	1.1	1.5	3.5	1.9	-0.0	1.0
Pack years adult smoking proportion	1.1	1.7	2.5	1.6	0.6	-1.5
Hair/balding pattern: Pattern 2	1.1	1.4	4.1	-2.0	-0.2	-0.0
Neuroticism score	1.1	2.2	3.4	-1.1	1.8	-1.4
Worrier / anxious feelings	1.1	2.0	2.4	-1.5	1.2	-1.5
Falls in the last year	1.1	1.5	3.9	0.8	-2.0	0.0
Overall health rating	1.1	2.3	5.1	-2.3	1.4	-0.1
Average weekly red wine intake	1.1	1.7	3.0	0.2	-1.4	1.7
Breast cancer (self-reported)	1.1	1.3	2.1	0.9	1.5	0.9
Age started oral contraceptive pill	1.1	1.3	4.0	2.0	0.1	0.0
Major Depression (MDD)	1.0	1.2	2.2	-0.2	1.5	-1.1
Fed-up feelings	1.0	1.9	3.0	-1.6	1.7	0.2
Financial difficulties in last 2 years	1.0	1.4	1.7	-1.2	1.3	-1.0
Pain all over the body in last month	1.0	1.1	1.8	0.5	-1.3	1.1
Impedance of arm (left)	1.0	4.6	9.1	0.3	-2.1	3.0
Exposure to tobacco smoke outside home	1.0	1.3	2.4	-1.2	1.6	-0.5
Medication: Allopurinol	1.0	1.3	3.0	-1.7	-0.2	0.9
Heart disease (mother)	1.0	1.3	2.8	1.7	1.0	0.0
Chest pain or discomfort	1.0	1.5	2.5	1.2	-1.6	0.7
Leg pain on walking	1.0	1.2	3.6	0.2	1.9	-0.1
Arm fat percentage (left)	1.0	3.9	6.3	-2.5	-1.1	2.0
Long-standing illness, disability or infirmity	1.0	1.6	3.7	-1.9	0.7	-0.7
Hearing aid user	1.0	1.1	3.0	-0.5	1.7	0.2
Medication: Blood pressure	1.0	2.0	4.9	-0.8	2.2	-0.6
Illnesses of father: High blood pressure	1.0	1.2	3.2	-1.8	0.6	-0.1
Depressed Affect (Nagel 2018)	0.9	1.9	4.7	-0.4	2.2	-0.9
Depression (Nagel 2018)	0.9	1.4	3.4	-0.1	1.8	-0.8
Neuroticism (2016)	0.9	1.3	1.7	0.9	1.3	-1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.7	1.3	0.1	-1.3
Number of incorrect matches in round	0.9	1.4	4.1	-0.2	0.4	-2.0
Hearing difficulty/problems with background noise	0.9	1.5	4.1	-0.6	2.0	-0.2
Allergy	0.9	2.1	5.1	2.3	1.0	-0.4
Arm fat percentage (right)	0.9	3.5	6.5	-2.5	-1.1	1.7
Prospective memory result	0.9	1.1	1.6	-0.7	1.3	-1.1
Body fat percentage	0.9	3.5	4.6	-2.1	-1.4	2.0
Shortness of breath walking on level ground	0.9	1.0	1.7	-1.3	-1.1	0.4
Qualifications: College or University degree	0.9	2.8	6.1	0.6	-1.4	2.5
Medication for pain relief, constipation, heartburn	0.9	1.5	3.2	1.0	0.6	-1.8
Medication: Ibuprofen	0.9	1.1	3.3	0.3	1.8	0.2
Family relationship satisfaction	0.9	1.1	1.7	-1.3	0.7	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	-1.5	-0.6	0.8
Mood swings	0.9	1.6	2.7	-1.6	0.9	-1.1
Back pain experienced in last month	0.9	1.4	3.7	-1.9	0.3	-0.6
Medication: Lisinopril	0.9	1.2	2.0	-0.7	1.0	-1.4
Risk taking	0.9	1.3	2.1	0.0	1.3	-1.4
Pain experienced in last month	0.9	1.6	3.7	1.0	-1.9	-0.3
Blood Eosinophil Count	0.8	6.3	12.2	1.4	-2.2	3.5
Sensitivity / hurt feelings	0.8	1.3	3.8	0.3	0.3	-1.9
Trunk fat percentage	0.8	3.4	4.7	-1.8	-1.5	2.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.4	0.2	0.4	1.6
Alcohol usually taken with meals	0.8	1.2	1.9	-1.3	-1.4	-0.2
Impedance of arm (right)	0.8	3.6	5.6	0.4	-2.2	2.4
Mouth/teeth dental problems: Dentures	0.8	1.4	2.2	0.5	1.5	-1.3
Wheeze or whistling in the chest in last year	0.8	1.3	2.2	0.6	-1.2	1.5
Osteoporosis (self-reported)	0.8	1.0	2.6	1.6	-0.1	0.7
Medication: Atorvastatin	0.8	1.0	1.6	-0.6	-1.0	1.3
Alcohol drinker status: Never	0.8	0.9	2.0	-1.4	0.8	0.4
Irritability	0.8	1.4	2.6	-1.1	1.6	-0.6
Ever depressed for a whole week	0.8	0.9	2.0	-0.2	0.9	-1.4
Supplements: Calcium	0.8	0.8	2.0	1.4	0.6	-0.4
HDL Cholesterol	0.7	1.1	2.0	-1.0	0.6	1.4
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	-0.5	0.4	-1.4
Townsend deprivation index at recruitment	0.7	1.0	1.2	0.8	1.0	-1.1
Forced vital capacity (FVC)	0.7	2.8	4.8	1.1	-2.2	1.5
Hair/balding pattern: Pattern 3	0.7	1.1	1.9	1.0	1.4	0.6
Noisy workplace	0.7	0.9	1.4	0.5	1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	0.1	1.2	1.2
Hair/balding pattern: Pattern 4	0.7	1.7	3.5	0.5	-1.9	1.1
Pulse wave reflection index	0.7	0.9	1.5	-1.0	0.4	-1.2
Gout (self-reported)	0.7	0.9	1.3	-1.0	1.2	0.7
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	-1.3	-0.1	-0.7
Unable to work because of sickness or disability	0.7	0.9	1.7	1.3	-0.9	0.5
Qualifications: CSEs or equivalent	0.6	0.7	1.2	-1.1	1.0	-0.1
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.5	-1.9	-0.7	0.4
Medication: Levothyroxine sodium	0.6	1.0	2.4	1.6	-0.7	0.2
Chronic bronchitis/emphysema (father)	0.6	0.8	1.6	-0.2	-0.8	1.3
Trunk fat mass	0.6	2.5	3.4	-1.8	-1.4	1.5
Had other major operations	0.6	0.8	1.5	-0.5	1.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.8	-0.5	0.5	-1.4
Pulse rate	0.6	1.1	2.7	0.4	0.6	1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.8	-0.7	-1.7	1.0
Depression (self-reported)	0.6	0.7	1.0	0.6	-0.9	-1.0
Arm fat mass (right)	0.6	2.3	5.0	-2.2	-0.8	1.1
Birth weight of first child	0.6	1.1	1.7	0.7	1.1	-1.3
Leg fat percentage (right)	0.6	2.3	4.2	-2.1	-1.0	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	-0.1	-0.6	1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	1.2	-0.8	0.2
Medication: Aspirin	0.6	0.8	1.0	-1.0	-1.0	0.8
Smoking status: Previous	0.6	0.9	2.4	0.3	-0.5	1.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.2	0.5	1.5	-0.5
Osteoarthritis (self-reported)	0.6	0.8	1.2	-0.1	1.1	-1.1
Medication: Aspirin	0.6	0.8	1.0	-1.0	-1.0	0.7
Arm fat mass (left)	0.6	2.5	5.1	-2.3	-0.8	1.4
Mother’s age at death	0.6	0.8	1.6	0.8	0.3	-1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.1	-0.8	0.7	-1.1
Leg fat percentage (left)	0.6	2.2	4.7	-2.2	-0.7	1.1
Number of operations (self-reported)	0.6	0.9	2.7	0.1	1.6	0.0
Alcohol drinker status: Previous	0.6	0.7	2.2	0.0	-0.0	-1.5
Impedance of whole body	0.6	3.1	5.1	0.9	-1.8	2.3
Bipolar Disorder (2018)	0.5	0.9	1.4	1.2	0.8	-0.7
Crohns Disease (2017)	0.5	1.2	3.3	1.8	0.5	-0.2
Primary Biliary Cirrhosis	0.5	0.7	1.7	0.5	1.3	-0.2
Rheumatoid Arthritis	0.5	0.7	1.9	0.1	1.4	-0.1
Schizophrenia (2014)	0.5	1.2	2.5	0.2	1.6	1.0
Triglycerides	0.5	0.8	0.9	0.8	-0.9	-0.9
Systolic Blood Pressure	0.5	2.6	7.2	0.5	2.7	-0.6
Hypothyroidism (self reported)	0.5	1.2	1.8	0.5	-1.4	1.2
Systolic blood pressure, automated reading	0.5	1.3	2.3	1.5	1.3	-0.2
Waist circumference	0.5	2.0	4.5	-2.1	-0.8	0.9
Had menopause	0.5	0.7	1.0	0.7	1.0	-0.7
Qualifications: None of the above	0.5	1.0	1.9	0.9	0.6	-1.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	0.9	-0.9	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.0	-0.1	-1.7	1.3
Exposure to tobacco smoke at home	0.5	0.6	1.3	0.2	1.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.3	1.1	-0.7	0.9
Birth weight	0.5	1.1	2.4	1.6	-0.2	0.8
Pulse wave peak to peak time	0.5	0.6	1.1	0.6	-1.1	0.5
Health satisfaction	0.5	0.6	1.6	-1.3	-0.1	-0.5
Medication: Blood pressure	0.5	0.9	1.6	-1.0	0.5	-1.3
Whole body fat mass	0.5	2.2	3.8	-1.9	-1.2	1.2
Age at last live birth	0.5	0.7	1.9	0.2	-0.4	1.4
Supplements: Vitamin C	0.5	0.6	1.2	-1.1	0.5	-0.5
Diabetes diagnosed by doctor	0.5	0.8	2.1	1.5	-0.6	0.2
Friendships satisfaction	0.5	0.6	1.3	-0.5	-0.5	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	0.5	0.8	1.0
Average weekly beer plus cider intake	0.5	0.8	2.2	0.0	-1.5	0.2
Myopia	0.5	0.7	1.5	0.0	1.2	-0.8
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	0.6	1.5	-0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	-0.8	1.0	0.1
Worry (Nagel 2018)	0.4	0.9	1.7	-0.2	1.3	-1.0
Ovarian Cancer	0.4	0.5	0.9	-1.0	-0.7	0.4
Age at First Birth	0.4	0.6	1.5	-0.0	0.4	1.2
Blood Red Count	0.4	4.1	5.1	-2.2	-2.1	1.7
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.5	1.6	-0.1	0.0
Relative age of first facial hair	0.4	0.9	2.5	-0.5	0.0	1.6
Diabetes (father)	0.4	0.5	0.7	-0.8	0.7	-0.7
Diabetes (mother)	0.4	0.5	1.2	-0.3	1.1	0.4
Impedance of leg (right)	0.4	2.0	2.3	1.5	-1.4	1.3
Current tobacco smoking	0.4	0.7	1.9	0.4	0.1	-1.4
Serious illness, injury or assault to yourself	0.4	0.5	1.3	-1.1	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	0.1	0.8	-1.0
Fluid intelligence score	0.4	0.9	2.2	0.7	-0.1	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.2	-1.1	-0.2	0.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.5	1.0	-0.5
Length of working week for main job	0.4	0.5	0.6	-0.8	-0.7	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	0.3	-0.6	-1.1
Worry too long after embarrassment	0.4	0.7	1.5	0.4	1.2	-0.5
Neck or shoulder pain in last month	0.4	0.6	1.7	0.1	-0.2	1.3
Leg fat mass (right)	0.4	1.5	2.8	-1.7	-0.9	1.0
Pulse rate, automated reading	0.4	1.3	1.6	-0.8	1.3	1.3
Number of full sisters	0.4	0.5	0.8	-0.7	-0.3	0.9
Illnesses of father: Heart disease	0.4	0.5	1.4	1.2	0.2	0.1
Smoking status: Current	0.4	0.6	1.7	0.4	-0.1	-1.3
Average weekly champagne plus white wine intake	0.4	0.6	1.0	0.6	-0.6	1.0
Financial situation satisfaction	0.4	0.5	0.9	-1.0	-0.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	0.1	0.8	-0.9
Leg fat mass (left)	0.4	1.6	3.1	-1.8	-0.8	1.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	-1.1	-0.3	1.3
Schizophrenia (2018)	0.3	0.6	1.7	0.1	1.3	0.4
HbA1C	0.3	0.4	0.6	-0.5	0.6	-0.8
BMI	0.3	1.9	4.2	-2.1	-1.0	0.6
Respiratory disease	0.3	0.7	2.0	-1.4	-0.3	0.4
Lung FVC	0.3	1.7	2.9	0.7	-1.7	1.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.8	0.8	-0.3
Hand grip strength (right)	0.3	0.8	2.0	-0.3	-1.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.2	0.9	0.3
Body mass index (BMI)	0.3	1.5	3.9	-2.0	-0.2	0.7
Impedance of leg (left)	0.3	1.5	2.2	1.5	-1.1	1.1
Past tobacco smoking	0.3	0.5	0.6	-0.8	0.5	-0.8
Heart attack	0.3	0.4	0.7	0.0	0.7	-0.9
Illnesses of siblings	0.3	0.4	1.1	-1.0	0.3	0.3
Trunk fat-free mass	0.3	1.8	4.0	-0.5	1.1	-2.0
Father’s age at death	0.3	0.4	1.1	-0.3	1.0	-0.3
Number of live births	0.3	0.5	1.2	1.1	0.2	-0.4
Happiness	0.3	0.4	0.7	-0.8	0.1	0.7
Asthma	0.3	0.6	0.8	-0.5	-0.9	0.8
Trunk predicted mass	0.3	1.8	4.0	-0.5	1.0	-2.0
Headache pain in last month	0.3	0.5	1.2	-0.5	1.1	-0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	0.9	0.5	0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	1.7	0.3	-1.3	1.1
Angina (self-reported)	0.3	0.3	0.6	-0.8	0.7	0.0
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.9	-0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	0.2	-0.8	-0.5
Had major operations	0.3	0.3	0.4	0.6	0.5	-0.5
Knee pain experienced in last month	0.3	0.4	0.8	0.5	0.9	-0.6
Asthma (self-reported)	0.3	0.6	0.8	-0.6	-0.9	0.7
Ever smoked	0.3	0.4	0.9	1.0	0.6	-0.1
Arm fat-free mass (left)	0.3	1.4	2.6	-0.8	0.9	-1.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.8	-0.2	0.6
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	1.1	0.1	-0.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.0	-0.2	-0.8
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.4	-0.6	0.3
Crohns Disease (2012)	0.2	0.3	0.6	0.2	0.8	-0.6
LDL Cholesterol	0.2	0.3	0.6	0.4	0.8	0.4
Lupus	0.2	0.4	0.8	0.6	0.0	-0.9
Angina	0.2	0.2	0.4	-0.6	0.5	-0.0
Medication: Co-codamol	0.2	0.3	0.4	-0.6	-0.2	0.6
Medication: Metformin	0.2	0.3	0.4	0.5	0.4	0.7
Leg fat-free mass (left)	0.2	0.8	2.5	-1.6	0.0	-0.1
Average weekly fortified wine intake	0.2	0.3	0.5	0.1	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	-0.8	-0.7	-0.0
Leg predicted mass (left)	0.2	0.9	2.6	-1.6	-0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.5	-1.0	0.1
Diabetes (self-reported)	0.2	0.3	0.8	0.9	-0.4	-0.2
Weight	0.2	1.2	2.6	-1.6	-0.6	0.8
Lung cancer (father)	0.2	0.2	0.5	0.3	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	-1.0	-0.6	0.9
Breastfed as a baby	0.2	0.2	0.5	0.1	-0.4	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	-0.3	-0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	-0.4	-0.9	0.3
Medication: Amlodipine	0.2	0.3	0.5	0.3	0.7	0.6
Arm fat-free mass (right)	0.2	1.0	2.0	-0.7	0.7	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.8	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.1	0.8	0.4
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.7	0.4	0.2
Arm predicted mass (right)	0.2	0.8	1.7	-0.6	0.7	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	1.0	0.7	-0.2
Whole body fat-free mass	0.2	1.1	2.0	-0.9	0.7	-1.4
Mineral and other dietary supplements	0.2	0.2	0.7	0.2	-0.1	0.8
Whole body water mass	0.2	1.0	1.7	-0.9	0.7	-1.3
Leg predicted mass (right)	0.2	0.8	2.2	-1.5	0.3	-0.5
Basal metabolic rate	0.2	0.9	1.9	-1.4	0.3	-0.8
Cholesterol lowering medication	0.2	0.2	0.3	-0.6	0.3	0.5
Arm predicted mass (left)	0.2	1.2	2.2	-0.7	0.9	-1.5
Ulcerative Colitis (UC)	0.1	0.2	0.6	-0.0	-0.2	-0.8
Fasting Glucose	0.1	0.1	0.2	0.4	0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.6	0.1	-0.1
Ulcerative Colitis	0.1	0.1	0.2	-0.4	-0.2	-0.2
Heel T-Score	0.1	0.7	1.6	-0.7	-1.3	-0.1
Height	0.1	1.9	3.4	1.8	1.5	0.3
Smoking Status	0.1	0.2	0.5	0.3	0.7	0.2
Allergy or Eczema	0.1	0.3	0.5	-0.5	-0.7	-0.2
Lung FEV1/FVC ratio	0.1	0.7	1.2	-1.0	1.1	0.3
Hair Pigment	0.1	2.3	4.9	0.1	-2.2	1.4
Tanning	0.1	0.9	2.5	-1.6	-0.1	-0.4
Hand grip strength (left)	0.1	0.2	0.3	-0.3	-0.5	0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	-0.4	0.0
Taking other prescription medications	0.1	0.2	0.6	-0.1	0.1	-0.8
Age when periods started (menarche)	0.1	0.3	0.8	-0.9	-0.1	0.5
Sitting height	0.1	0.5	1.4	0.1	-1.2	0.3
Medication: Simvastatin	0.1	0.2	0.6	-0.1	0.0	-0.7
Hip circumference	0.1	0.4	0.8	-0.9	-0.6	0.4
Time employed in main current job	0.1	0.1	0.2	-0.2	0.5	-0.0
Medication: Cholesterol lowering	0.1	0.2	0.3	-0.3	-0.6	-0.3
Tense / ‘highly strung’	0.1	0.2	0.4	-0.6	-0.5	-0.1
Peak expiratory flow (PEF)	0.1	0.2	0.7	-0.2	-0.8	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.1	0.3	-0.4
Loud music exposure frequency	0.1	0.2	0.4	0.1	0.1	-0.7
High blood pressure (siblings)	0.1	0.1	0.3	-0.1	0.0	-0.6
Comparative body size at age 10	0.1	0.3	0.8	-0.3	0.3	-0.9
Age at first live birth	0.1	0.1	0.2	0.4	-0.2	0.5
Comparative height size at age 10	0.1	0.7	1.3	1.0	-0.0	-1.1
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.1	-0.3	0.6
Leg fat-free mass (right)	0.1	0.8	2.1	-1.4	0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.4	0.6	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.1	0.5	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.5	-0.1	0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	-0.0	-0.6
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.3	0.0	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.2	0.0
Blood White Count	0.0	0.2	0.3	0.1	0.6	0.6
Chronotype (morning person)	0.0	0.1	0.3	-0.1	0.0	-0.5
Relative age voice broke	0.0	0.1	0.1	-0.2	0.2	0.3
Standing height	0.0	0.3	0.6	0.6	-0.8	0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.3	-0.2	0.1
Wears glasses or contact lenses	0.0	0.1	0.1	0.3	0.1	-0.3
High cholesterol (Self-reported)	0.0	0.1	0.1	0.1	0.2	-0.4
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

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Trait associations