Hub : Genes

PDE1B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0880	0.0320	1.1e-03	0.002	0.027	0.017	0.027	0.011	1.5e-01	3.0e-04	2.8e-03	2.7e-04	1.3e-02
2	GTEx	Adipose Subcutaneous	0.1480	0.0480	1.2e-03	0.102	NA	0.109	NA	0.101	1.1e-08	NA	3.5e-09	NA	1.4e-08
3	GTEx	Artery Aorta	0.1480	0.0580	5.5e-03	0.146	NA	0.103	NA	0.112	2.0e-08	NA	2.7e-06	NA	9.9e-07
4	GTEx	Liver	0.4450	0.1200	1.5e-03	-0.006	NA	0.144	NA	0.082	4.9e-01	NA	8.2e-05	NA	2.7e-03
5	METSIM	Adipose	0.0458	0.0190	2.9e-03	0.050	0.004	0.030	0.025	0.039	5.5e-08	7.2e-02	2.0e-05	1.1e-04	1.5e-06
6	YFS	Blood	0.1412	0.0258	0.0e+00	0.085	0.090	0.116	0.119	0.123	2.9e-26	8.5e-28	5.9e-36	6.5e-37	3.8e-38
7	TCGA	Breast Invasive Carcinoma	0.0603	0.0190	1.4e-06	0.046	0.030	0.047	NA	0.043	7.5e-10	7.5e-07	5.7e-10	NA	2.7e-09
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0592	0.0309	9.6e-03	0.005	-0.001	0.001	NA	0.004	8.4e-02	4.9e-01	2.5e-01	NA	1.0e-01
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0670	0.0390	5.8e-03	-0.003	0.004	-0.003	NA	-0.004	6.3e-01	1.7e-01	6.7e-01	NA	9.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.8	1.3	3.7	-1.9	-1.5	0.9	-0.9	-0.9	0.8	-1.3	0.9	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	3.1	-1.7	-0.7	0.1	-1.8	0.0	0.3	-0.2	0.0	-1.4
Depressed Affect (Nagel 2018)	0.3	0.5	2.6	-0.9	-0.3	0.8	-0.6	-0.0	1.6	-0.5	-0.3	-0.3
Depression (Nagel 2018)	1.1	1.6	3.1	-1.1	-1.7	1.7	0.8	-1.1	1.2	-1.8	-0.1	0.7
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.2	1.2	1.8	-1.6	-1.0	1.6	-1.8	1.4	-1.0	-0.8
Neuroticism (Nagel 2018)	0.7	1.6	4.6	-1.5	-1.0	1.5	0.6	-1.0	2.1	-1.1	-0.1	-1.2
Schizophrenia (2018)	0.3	0.7	2.4	-0.6	0.4	-0.7	-1.2	0.0	-0.5	1.1	0.0	-1.6
Schizophrenia vs Biploar Disorder	0.4	0.5	2.8	1.7	-0.1	0.1	0.9	0.0	0.2	0.0	0.0	0.9
Worry (Nagel 2018)	1.0	2.2	5.3	-1.4	-1.3	1.9	0.9	-1.8	2.3	-1.6	0.4	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	1.6	0.3	1.2	-0.7	-0.1	0.4	-0.9	0.5	-0.0	0.3
Alzheimer’s Disease (in father)	2.1	2.3	6.0	0.2	1.5	-1.7	-1.2	1.8	-2.5	1.8	-0.2	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	-0.9	0.9	-0.7	-1.1	0.5	-1.5	0.6	0.5	-0.5
Crohns Disease (2017)	0.9	1.9	7.9	0.7	-1.2	0.6	2.8	-0.9	0.6	-0.7	2.1	1.0
Irritable Bowel Disease (IBD)	0.8	1.9	7.1	-0.0	-1.2	1.0	1.9	-1.0	0.9	-1.2	2.7	0.9
Ulcerative Colitis (UC)	0.6	1.1	3.3	-0.8	-0.9	1.2	0.2	-0.8	0.7	-1.4	1.8	0.5
Major Depression (MDD)	0.5	0.6	1.8	0.5	0.6	-0.6	-1.0	0.8	-1.3	0.6	-0.7	0.1
Reaction Time	1.3	2.4	12.1	0.8	-1.4	1.3	1.5	-1.2	0.6	-1.2	0.0	3.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.3	0.6	0.6	-0.6	-0.6	0.6	-1.5	0.7	-0.7	-0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.3	0.5	1.9	-1.4	-0.2	0.3	-0.2	0.0	0.6	-0.1	0.5	-1.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.2	0.5	-0.1	0.2	0.9	-0.2	1.1	-0.2	0.3	0.5
Bipolar Disorder (2011)	0.0	0.0	0.2	0.1	-0.5	0.0	0.1	0.0	0.0	0.0	0.0	0.2
Body Mass Index (BMI) (2010)	0.6	0.8	3.6	-1.0	0.3	-0.5	-1.9	0.6	-0.9	0.2	0.9	0.9
Coronary Artery Disease (CAD)	0.4	0.4	1.3	-0.3	1.1	-1.0	-0.9	0.0	-0.4	0.0	0.0	-0.7
Crohns Disease (2012)	1.1	1.7	6.7	-0.8	-1.4	0.6	2.6	-0.8	0.9	-0.7	1.9	0.6
Mean Putamen Volume	0.1	0.1	0.4	0.2	0.5	-0.1	0.4	0.4	-0.6	-0.2	0.2	0.3
Fasting Glucose	0.5	0.5	2.8	0.3	0.2	-0.2	0.3	0.7	-0.3	0.7	-0.8	1.7
HbA1C	1.1	1.2	3.7	-0.7	-0.6	1.1	1.2	-0.7	1.1	-1.4	1.9	-0.5
HDL Cholesterol	1.8	3.0	5.4	1.0	1.8	-2.1	1.4	1.9	-1.6	2.3	-1.4	-1.5
LDL Cholesterol	0.4	0.6	2.2	-0.3	-1.1	0.3	1.5	-0.8	0.8	-0.3	-0.5	0.6
Lupus	0.4	0.6	3.0	0.2	0.7	0.0	0.3	-0.2	-0.5	-0.0	-1.7	1.3
Neuroticism (2016)	0.4	0.5	2.3	-1.5	-0.2	0.2	-0.9	-0.0	0.2	-0.3	0.7	-1.0
Primary Biliary Cirrhosis	0.7	1.0	5.4	-2.3	0.3	-0.3	-1.4	0.5	-1.0	0.4	-0.0	-0.2
Rheumatoid Arthritis	0.8	1.1	2.4	0.4	1.4	-1.5	1.1	1.1	-0.4	1.3	-0.8	0.7
Schizophrenia (2014)	0.3	0.7	3.6	-0.7	0.2	-0.6	-1.4	0.0	-0.1	0.0	0.0	-1.9
Triglycerides	2.5	4.1	7.7	-1.3	-2.5	2.7	0.7	-2.2	1.5	-2.8	1.4	1.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	4.0	2.0	0.2	-0.0	0.3	0.1	-0.2	-0.1	-0.4	1.3
Ulcerative Colitis	0.4	0.6	1.3	-0.9	-1.1	1.0	-0.7	0.0	0.9	-1.1	0.0	0.4
Blood Eosinophil Count	0.1	0.4	2.1	1.5	0.8	-0.4	-0.1	0.3	-0.2	-0.3	0.7	0.4
Blood Platelet Count	1.7	19.2	63.8	6.9	5.3	-3.0	-8.0	3.5	-1.1	2.7	-1.9	0.6
Blood Red Count	0.1	1.4	5.8	1.7	1.5	-0.4	-2.4	0.2	-0.9	0.2	-0.9	0.2
Blood White Count	0.3	2.5	11.0	2.0	-0.8	0.7	-3.3	-0.4	0.7	-0.5	0.8	2.2
Heel T-Score	0.1	0.6	2.6	1.1	0.4	0.0	-0.4	0.0	1.1	-0.1	1.6	0.2
BMI	0.6	3.5	8.8	-0.9	1.2	-2.3	-1.5	2.6	-3.0	1.9	0.3	-1.4
Height	0.2	3.4	10.0	-3.2	-1.6	1.6	1.8	-1.3	1.0	-1.9	1.4	-2.1
Waist Hip Ratio (WHR)	0.4	1.8	13.3	0.2	0.1	0.6	3.6	-1.3	0.9	-0.4	0.2	-0.3
Systolic Blood Pressure	1.5	7.3	14.5	0.5	2.2	-2.5	-2.6	3.0	-3.8	2.6	-2.4	-3.3
Smoking Status	0.3	0.7	1.6	0.6	0.8	-1.0	0.2	0.8	-0.6	0.9	-1.0	-1.3
Allergy or Eczema	0.1	0.3	1.3	0.5	-0.9	0.2	-0.2	-0.6	0.4	-0.1	1.1	0.4
Cardiovascular Disease	0.9	3.0	9.5	2.1	1.3	-1.4	-2.0	1.6	-3.1	1.2	-1.0	-0.8
Hypothyroidism (self reported)	0.2	0.6	1.6	-1.1	0.4	-0.3	-1.3	0.3	-1.2	0.2	0.4	-0.4
Respiratory disease	0.2	0.5	1.4	1.0	0.8	-0.2	1.1	0.4	-0.3	-0.2	0.4	1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.0	-0.2	-0.4	0.3	-1.4	-0.6	0.5	-0.5	1.7	0.2
Lung FEV1/FVC ratio	0.4	2.0	6.0	-1.3	-1.7	0.8	-2.5	-1.1	-0.5	-1.0	2.0	0.4
Lung FVC	0.2	0.8	3.0	0.8	-0.2	0.8	1.7	-0.1	1.0	-0.6	0.9	0.9
Neuroticism	0.6	1.4	5.1	-0.3	-0.7	1.2	1.2	-1.3	2.3	-1.1	0.5	-0.9
Chronotype (morning person)	0.1	0.2	0.8	-0.2	-0.9	0.5	0.6	-0.2	-0.4	-0.3	0.4	0.2
Hair Pigment	0.0	1.0	2.2	-0.1	1.3	-1.1	0.2	1.0	-1.5	1.5	-0.7	-0.4
Tanning	0.3	3.4	7.7	0.6	-2.0	2.1	2.8	-1.9	2.0	-2.1	1.4	-0.2
Hand grip strength (left)	0.3	0.7	2.4	-1.5	0.1	-0.7	-0.8	0.7	-0.2	0.7	-1.0	-0.8
Number of treatments/medications taken	0.5	0.8	1.4	0.7	-1.1	1.2	-0.9	-0.8	0.1	-0.9	0.9	1.1
Average weekly spirits intake	0.3	0.4	1.8	0.3	0.7	0.3	0.0	0.1	-0.7	-0.5	-0.1	1.4
Sensitivity / hurt feelings	0.7	1.3	5.7	-2.4	0.1	0.4	-0.0	-0.6	1.3	-0.7	0.8	-1.5
Frequency of depressed mood in last 2 weeks	2.3	3.2	6.0	-1.9	-2.1	2.1	0.1	-2.1	2.4	-2.1	1.1	0.8
Hearing difficulty/problems: Yes	0.5	0.8	5.5	-0.0	-0.6	0.2	2.3	-0.3	-0.7	-0.4	0.5	0.4
Relative age of first facial hair	0.7	1.4	6.7	-1.4	-0.1	-0.3	-0.8	-0.2	0.2	0.2	2.6	-1.8
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.4	-0.6	-1.1	1.4	0.1	-1.5	0.9	-1.0	0.8	0.6
Ever used hormone-replacement therapy (HRT)	2.1	2.7	4.0	1.9	-1.7	1.7	1.9	-1.3	1.5	-2.0	1.0	1.5
Ever had hysterectomy (womb removed)	0.6	0.7	2.0	0.7	-0.6	0.6	1.4	-0.2	0.8	-0.9	0.3	-1.2
Systolic blood pressure, automated reading	0.7	2.1	7.1	0.5	1.1	-1.2	-1.0	1.7	-2.7	1.1	-1.4	-1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	5.3	0.5	0.4	-0.5	-2.3	0.1	0.3	0.4	0.2	1.1
Angina	0.5	0.7	1.6	-1.0	-1.0	0.8	-1.0	0.1	-0.1	-0.8	1.3	-0.7
Medication for hormone replacement therapy	0.7	0.8	1.5	1.0	1.2	-0.9	1.0	0.7	-0.1	0.9	-0.6	-1.1
Vitamin and mineral supplements	0.3	0.4	1.7	-0.0	0.7	-0.4	-1.3	0.8	0.2	-0.0	-0.4	0.1
Supplements: Zinc	0.3	0.3	1.3	0.1	-0.8	0.4	0.5	0.1	-0.3	-0.3	-0.3	-1.1
Medication: Co-codamol	0.1	0.1	0.3	0.5	0.2	0.3	0.6	-0.1	-0.1	-0.0	-0.2	-0.4
Medication: Metformin	0.7	1.0	5.5	2.3	0.3	-0.3	0.0	0.2	0.6	0.2	-1.5	0.9
Diabetes (father)	0.1	0.2	0.5	0.4	0.3	-0.0	0.6	-0.2	0.1	0.1	-0.7	0.6
Diabetes (mother)	0.3	0.3	1.3	0.2	0.0	-0.3	-0.9	0.4	0.3	0.7	0.3	-1.1
Severe depression (siblings)	0.8	0.9	3.1	-1.8	0.5	-0.8	-0.9	0.5	-1.3	0.8	-0.5	-0.9
Pack years adult smoking proportion	1.1	1.6	7.7	0.9	-1.1	1.4	0.5	-0.9	0.4	-1.4	-0.3	2.8
Impedance of leg (right)	0.3	1.4	5.6	2.2	0.5	-0.1	2.4	-0.4	0.1	0.0	1.1	0.6
Leg fat-free mass (left)	0.2	1.3	4.6	-2.1	0.0	-0.5	-0.1	1.1	-0.9	0.4	-1.0	-1.9
Trunk fat percentage	0.3	1.4	3.9	-0.5	0.8	-1.2	1.7	1.5	-2.0	0.9	0.3	-0.2
Hand grip strength (right)	0.8	2.1	4.2	-1.1	1.1	-1.5	-1.1	1.7	-1.5	1.6	-2.0	-1.1
Townsend deprivation index at recruitment	1.1	1.5	4.7	0.2	-1.6	1.7	0.5	-1.0	0.4	-1.2	0.6	2.2
Current tobacco smoking	0.3	0.4	1.7	1.0	0.2	0.1	-0.5	-0.2	0.6	-0.3	-0.7	1.3
Average weekly fortified wine intake	0.5	0.6	3.5	0.1	-0.2	0.2	0.6	-0.6	1.0	0.0	-0.3	1.9
Maternal smoking around birth	0.6	0.8	2.6	-0.9	-1.4	0.6	1.6	-0.8	0.1	-0.5	0.9	-0.3
Fed-up feelings	0.3	0.5	2.2	-0.4	-0.5	0.7	-0.0	-0.6	1.5	-0.8	0.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.9	-0.8	-1.6	1.6	0.5	-1.1	0.8	-1.7	-0.1	1.0
Relative age voice broke	0.6	1.0	2.9	-1.5	-0.7	0.7	0.0	-1.2	0.7	-0.2	1.7	-0.9
Taking other prescription medications	3.3	5.1	11.2	0.2	-2.5	2.6	-0.1	-2.6	2.2	-2.6	3.4	1.9
Age when periods started (menarche)	0.4	1.1	2.5	-1.0	-0.8	1.4	-0.1	-1.4	0.7	-1.0	-0.2	1.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	-0.7	-0.4	0.5	0.5	-0.0	-0.2	-0.8	0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	0.0	0.7	-0.6	0.5	0.4	-0.9	0.7	-1.0	-0.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.5	-1.0	-1.0	0.7	-0.4	-0.8	1.6	-0.9	0.9	-0.6
Qualifications: CSEs or equivalent	0.5	0.6	3.8	0.7	0.2	0.3	1.9	-0.1	0.8	0.0	-0.9	0.1
Serious illness, injury or assault to yourself	0.2	0.3	1.2	-0.0	0.2	-0.3	-1.1	0.4	0.4	0.6	-0.5	0.4
High blood pressure	0.8	2.2	5.5	1.6	1.1	-0.9	-2.4	1.1	-1.7	0.7	-1.9	-1.1
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.8	0.9	0.6	-1.7	-0.7	1.1	-1.1	1.7	-0.7	-2.0
Multivitamins +/- minerals	0.5	0.6	1.9	-0.2	-1.4	0.9	0.8	-1.2	0.3	-0.5	-0.0	0.5
Stomach or abdominal pain in last month	1.1	1.3	2.9	0.6	-1.5	1.3	1.7	-1.1	1.4	-1.0	0.7	-0.2
Supplements: Glucosamine	1.0	1.3	3.0	1.1	-1.7	1.5	1.1	-1.2	0.1	-1.3	0.8	0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.9	0.8	1.0	-1.2	0.6	0.9	-0.8	1.3	-1.4	-0.3
Medication: Atenolol	1.0	1.3	3.1	0.4	1.0	-1.2	-0.8	1.4	-1.5	1.0	-0.1	-1.8
Medication: Levothyroxine sodium	0.2	0.4	1.6	0.2	0.7	-0.5	-1.3	0.3	-0.8	0.4	-0.3	0.1
Sitting height	0.2	1.4	6.4	-1.8	-0.5	0.4	1.4	-0.5	0.3	-0.7	-0.0	-2.5
Chronic bronchitis/emphysema (father)	0.4	0.5	2.7	-0.3	0.8	-0.5	-0.5	0.3	0.0	0.2	0.1	-1.6
High blood pressure (mother)	1.4	2.0	7.3	-0.2	0.3	-1.2	-2.7	0.8	-1.2	0.9	0.1	-2.5
Body mass index (BMI)	0.3	1.1	3.3	-0.4	0.5	-1.2	-0.7	1.7	-1.8	0.9	-0.1	-0.5
Impedance of leg (left)	0.3	1.4	7.0	2.2	0.6	-0.2	2.6	-0.3	0.1	0.1	0.8	0.1
Leg predicted mass (left)	0.2	1.3	5.0	-2.2	-0.1	-0.4	-0.0	1.0	-0.8	0.3	-0.9	-1.9
Trunk fat mass	0.3	1.2	3.7	-1.0	0.6	-1.1	1.3	1.5	-1.9	0.7	0.3	-0.7
Waist circumference	0.2	0.6	1.8	-0.9	0.2	-0.5	1.1	0.9	-1.4	0.2	-0.0	-0.3
Number of incorrect matches in round	2.1	3.4	6.5	-1.7	-2.3	2.2	-0.6	-1.8	1.4	-2.2	2.5	1.1
Past tobacco smoking	0.2	0.3	1.1	-0.3	0.2	0.8	-1.0	-0.7	0.6	-0.5	-0.2	0.2
Alcohol usually taken with meals	0.5	0.9	1.9	-1.3	0.7	-0.7	-1.2	0.5	-0.6	0.4	1.4	-1.0
Nervous feelings	2.0	3.7	8.6	-2.9	-1.8	2.4	0.3	-1.9	2.0	-2.5	1.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.0	-0.5	0.4	-0.4	-0.4	0.3	-0.5	0.9	-0.7
Hearing difficulty/problems with background noise	1.1	1.7	3.1	0.4	1.3	-1.8	1.0	1.6	-1.5	1.4	-0.4	-1.5
Hair/balding pattern: Pattern 2	1.7	2.2	7.2	2.7	0.9	-1.7	1.0	1.8	-0.7	1.4	-1.4	-0.7
Had menopause	2.7	3.4	8.1	0.6	-1.5	1.6	1.4	-2.0	2.0	-2.1	2.8	1.8
Had other major operations	0.3	0.4	2.8	1.7	0.5	-0.2	0.5	0.0	0.4	0.1	-0.2	0.5
Forced vital capacity (FVC)	0.3	1.1	6.8	-1.3	0.3	-0.1	1.0	0.4	-0.1	0.2	-0.0	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.3	0.1	1.2	-1.1	0.1	0.9	-0.9	1.1	-1.5	-0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.2	0.8	-0.8	0.7	0.7	-0.2	0.6	-0.9	-1.1
Qualifications: None of the above	0.7	1.6	8.2	0.6	-1.2	1.1	0.3	-0.8	0.8	-0.9	-0.8	2.9
Financial difficulties in last 2 years	1.6	2.1	3.7	1.2	-1.8	1.8	0.6	-1.3	1.9	-1.7	1.6	0.5
Mouth/teeth dental problems	0.4	0.6	2.9	-0.8	-0.4	0.2	-1.7	-0.3	0.0	-0.3	0.8	-1.0
Heart attack	0.5	0.6	2.2	0.6	0.4	-0.3	1.5	0.4	-1.0	0.4	-0.7	1.0
Allergy	0.1	0.1	0.5	-0.3	0.7	0.2	0.0	0.2	-0.1	-0.3	-0.7	0.1
Pain all over the body in last month	0.2	0.2	0.9	0.5	0.5	-0.0	-0.9	-0.1	-0.6	0.2	-0.2	0.2
Diabetes (self-reported)	0.6	1.0	7.6	0.5	-0.3	0.2	-2.8	-0.3	0.5	-0.2	-0.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.4	-0.5	-1.3	0.7	-0.1	-1.2	0.9	-0.8	1.9	0.9
Medication: Ramipril	0.6	0.7	2.8	1.7	-0.8	0.8	0.7	-0.3	0.4	-0.7	0.0	1.1
Medication: Simvastatin	1.0	1.5	4.0	0.7	-1.7	1.4	-0.2	-0.5	-0.1	-1.3	1.5	2.0
Fluid intelligence score	0.3	0.6	1.7	0.9	0.7	-0.2	-0.1	0.4	-1.3	0.5	-0.3	-1.3
Illnesses of siblings	0.2	0.3	0.5	0.3	-0.2	0.7	0.2	-0.7	0.6	-0.6	-0.1	0.7
Neuroticism score	0.8	1.6	6.0	-1.2	-0.8	1.5	-0.4	-1.4	2.5	-1.3	0.0	-0.3
Weight	0.3	1.5	3.2	-1.5	0.4	-1.2	0.1	1.7	-1.8	0.8	-0.1	-1.8
Impedance of arm (right)	0.2	0.9	4.7	0.0	1.0	-0.6	2.2	-0.6	0.1	0.5	1.0	0.0
Arm fat percentage (right)	0.2	0.9	2.5	-1.1	0.7	-1.1	0.6	1.3	-1.6	0.8	0.4	-0.5
Trunk fat-free mass	0.2	1.0	4.2	-1.7	-0.6	0.0	-0.4	0.6	-0.6	-0.1	-0.8	-2.1
Hip circumference	0.4	1.8	4.9	-1.1	0.9	-1.6	-0.5	2.0	-2.2	1.0	-0.3	-1.3
Time employed in main current job	0.7	0.9	2.0	1.4	0.8	-1.0	-0.0	1.0	-1.2	1.1	0.2	0.6
Alcohol intake versus 10 years previously	0.4	0.6	2.4	-0.3	-1.6	0.7	0.3	-0.8	1.0	-0.8	0.4	-0.1
Father’s age at death	0.7	0.9	1.4	-0.9	-1.2	1.1	-1.0	-1.1	0.3	-0.9	0.9	-1.0
Worrier / anxious feelings	1.1	2.2	4.2	-0.8	-1.2	1.8	1.9	-2.0	2.0	-1.5	0.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.8	0.2	0.0	0.1	1.3	0.2	-0.1	0.0	-0.7	0.2
Falls in the last year	0.5	0.7	4.5	-0.5	0.6	-0.4	-0.9	0.3	-0.6	0.1	-0.2	2.1
Hair/balding pattern: Pattern 3	1.0	1.5	2.8	-0.5	-1.2	1.4	0.6	-1.4	1.5	-1.4	1.7	0.4
Number of live births	0.2	0.3	1.4	0.3	0.4	-0.2	-0.9	-0.1	0.2	0.2	-0.5	-1.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	6.9	-1.7	-0.0	-0.1	0.3	0.3	-0.3	0.2	0.1	-2.6
Pulse rate	1.0	1.8	3.5	-1.9	-0.9	1.5	-1.2	-1.3	1.9	-1.4	0.7	-0.4
Happiness	3.4	4.1	9.7	2.0	2.2	-1.8	1.7	1.9	-2.4	1.8	-3.1	-0.1
Noisy workplace	3.8	4.7	10.2	-1.1	-2.6	3.2	0.7	-2.5	2.9	-2.8	0.4	1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.0	-1.2	0.9	-0.7	-1.1	0.5	-2.0	0.8	-0.8	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	2.0	0.4	-0.1	-0.4	-0.6	-0.2	0.6	0.5	-0.0	-1.4
Mouth/teeth dental problems: Dentures	1.2	2.1	5.3	-1.2	-1.8	1.6	0.3	-1.2	0.9	-1.5	2.3	1.2
Asthma	0.4	0.9	2.9	1.7	0.9	-0.8	0.4	0.7	-0.3	0.8	-1.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.7	0.2	-0.4	-0.1	1.3	-0.1	0.5	0.4	-0.2	-0.4
Medication: Cholesterol lowering	0.7	1.2	3.6	1.0	-1.2	0.9	-1.0	-0.5	0.1	-0.9	1.2	1.9
Depression (self-reported)	1.9	2.2	5.5	-2.3	-0.9	1.0	-2.4	-0.9	1.2	-1.3	1.4	1.2
Medication: Lansoprazole	1.4	1.6	4.3	-2.1	-0.7	0.6	-0.9	-0.7	0.9	-1.0	2.0	-1.3
Prospective memory result	0.2	0.2	1.2	1.1	0.1	-0.2	0.8	0.4	-0.1	0.3	0.1	0.3
Lung cancer (father)	0.3	0.4	1.1	-0.2	1.0	-0.6	-0.7	0.3	-0.3	0.8	-0.7	-0.5
Illnesses of mother	1.0	1.2	3.2	-0.5	-0.7	1.3	1.1	-0.9	1.3	-1.1	-0.6	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	7.7	-0.7	0.6	-0.7	0.3	0.7	-0.7	0.9	-0.9	-2.8
Pulse wave Arterial Stiffness index	0.5	0.5	3.5	0.1	0.3	0.0	1.9	0.0	-0.1	-0.1	-0.9	-0.6
Impedance of arm (left)	0.2	1.1	5.3	0.6	1.4	-1.0	2.3	-0.1	-0.1	0.8	0.5	0.8
Arm fat mass (right)	0.3	1.3	3.9	-1.1	0.6	-1.3	0.3	1.6	-2.0	0.9	0.2	-1.1
Trunk predicted mass	0.2	1.0	4.2	-1.8	-0.7	0.1	-0.5	0.6	-0.7	-0.1	-0.7	-2.0
Standing height	0.2	1.8	7.7	-2.3	-0.2	-0.2	1.7	0.1	-0.3	-0.1	0.0	-2.8
Length of working week for main job	1.2	1.4	5.3	-0.8	0.8	-0.9	-2.3	0.9	0.1	0.6	0.7	-1.8
Exposure to tobacco smoke at home	2.4	2.7	6.2	0.6	-2.5	1.9	1.7	-1.4	1.7	-1.9	0.9	1.1
Breastfed as a baby	1.1	1.4	3.2	1.6	1.8	-1.5	-0.2	1.1	-0.8	1.2	-0.2	1.1
Tense / ‘highly strung’	0.5	0.8	4.1	-1.3	0.3	-0.1	-1.0	0.3	0.4	-0.0	-0.5	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-1.1	-0.7	0.5	-1.0	-1.0	0.6	-0.8	1.3	-1.1
Hair/balding pattern: Pattern 4	0.3	0.8	2.6	0.2	1.3	-0.7	1.1	0.7	-0.5	0.4	-1.6	-0.4
Birth weight of first child	0.3	0.6	1.9	-1.2	-0.5	-0.5	-0.8	0.3	-0.2	0.3	1.4	-0.8
Peak expiratory flow (PEF)	0.3	0.7	4.0	-2.0	-0.7	0.3	0.1	-0.4	0.2	-0.4	0.1	-1.0
Pulse wave reflection index	1.5	1.9	13.2	0.9	1.0	-0.6	3.6	0.6	-0.6	0.5	-0.9	-0.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	5.3	-1.1	0.8	-0.6	-1.0	0.3	-0.8	0.6	0.1	-2.3
Loud music exposure frequency	0.5	0.6	1.4	0.0	-0.9	1.0	1.2	-0.3	-0.1	-1.1	0.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.5	0.8	1.0	-0.6	-1.5	0.5	-1.6	0.7	-0.2	-0.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	6.6	1.3	1.6	-1.4	1.8	0.9	-0.8	1.5	-2.6	-0.5
Blood clot in the leg (DVT)	10.2	13.2	25.1	-3.4	-5.0	4.3	0.2	-4.6	3.4	-4.0	3.2	2.3
Medication: Paracetamol	0.2	0.4	1.1	0.1	0.5	-0.3	-0.3	0.6	-1.0	0.6	-1.0	-0.1
Headache pain in last month	0.4	0.8	4.7	-0.5	-0.3	-0.5	2.2	0.2	0.1	0.5	-1.1	-0.4
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	8.5	-1.2	0.3	-0.4	2.9	-0.1	0.7	0.3	0.1	-2.0
Glaucoma (self-reported)	0.2	0.2	0.7	-0.6	0.3	-0.2	-0.4	0.3	-0.2	0.4	-0.6	0.8
Gout (self-reported)	1.0	1.3	2.7	-0.8	-1.1	1.2	-1.3	-1.5	1.6	-0.8	1.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	-0.6	0.1	0.3	-0.9	-0.3	-0.4	-0.4	0.9	0.2
Medication: Amlodipine	0.4	0.6	2.4	0.9	0.3	-0.4	-1.5	0.4	-0.1	0.4	-1.0	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	1.2	0.5	-0.1	0.1	-0.0	-0.3	0.1	-1.0	0.8
Birth weight	0.6	1.3	6.9	-2.6	-0.9	0.8	0.9	-0.7	-0.3	-1.0	0.7	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.8	-0.0	-0.0	0.2	1.3	-0.1	0.1	-0.3	1.4	0.1
High blood pressure (siblings)	0.2	0.3	1.0	-0.5	0.2	-0.1	-1.0	0.0	0.6	0.1	0.5	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	5.8	-0.8	0.6	-0.3	1.1	0.5	-0.4	0.5	-0.6	-2.4
Body fat percentage	0.3	1.1	3.4	-0.6	0.8	-1.2	1.3	1.4	-1.8	0.8	0.5	-0.2
Leg fat percentage (right)	0.2	0.6	1.8	0.0	0.3	-0.6	0.8	1.0	-1.3	0.2	1.0	0.2
Arm fat-free mass (right)	0.2	0.9	2.5	-1.2	-0.4	-0.3	-0.2	1.3	-1.2	0.2	-1.0	-1.6
Exposure to tobacco smoke outside home	0.7	0.9	1.4	1.2	-1.1	1.0	-0.1	-0.9	1.0	-1.1	-0.3	1.1
Comparative body size at age 10	0.2	0.4	1.7	1.3	0.4	-0.5	0.0	0.9	-0.5	0.6	-0.6	0.4
Number of full brothers	1.2	1.5	3.4	0.8	-1.6	1.5	0.8	-1.7	1.8	-1.2	-0.3	0.3
Worry too long after embarrassment	0.9	1.5	4.0	-1.2	-0.3	0.9	1.8	-1.4	2.0	-0.8	-0.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	-1.3	0.4	-0.7	-0.5	0.2	-0.0	0.6	0.2	-1.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.0	0.9	0.7	-0.7	0.1	0.8	-1.0	0.7	-0.3	0.6
Number of children fathered	0.6	0.6	2.2	-0.3	-0.7	0.7	1.5	-1.0	0.8	-0.8	0.4	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	5.4	0.2	0.4	-0.4	-2.3	0.3	0.1	0.7	-0.0	-1.3
Age at first live birth	0.3	0.5	0.9	0.5	0.9	-0.8	0.4	0.7	-0.7	0.9	-0.1	-0.7
Pulse wave peak to peak time	0.3	0.3	2.5	-0.0	-0.1	-0.2	-1.6	0.2	-0.1	0.3	0.6	0.2
Health satisfaction	0.5	0.7	1.5	1.2	0.7	-1.0	0.9	1.0	-1.0	0.6	-0.0	-0.6
Shortness of breath walking on level ground	0.2	0.3	1.5	-0.2	0.7	-0.2	-0.3	0.0	0.4	-0.1	0.2	1.2
Qualifications: College or University degree	0.4	1.1	2.6	-0.6	1.6	-1.0	-1.5	0.0	-1.0	0.9	0.1	-1.5
Eye problems/disorders: None of the above	0.8	0.9	2.9	1.1	0.2	-0.5	1.2	0.5	-0.3	0.6	-1.1	-1.7
Mouth/teeth dental problems: Loose teeth	3.0	3.6	9.3	1.1	1.9	-2.5	-0.9	2.5	-3.1	2.1	-0.5	0.3
Emphysema/chronic bronchitis	1.9	2.2	3.9	-1.0	-1.4	1.6	-0.0	-1.6	1.5	-1.7	1.6	2.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	0.0	-0.2	0.4	0.3	-0.8	0.9	-0.7	-0.4	-0.8
Neck or shoulder pain in last month	0.5	0.8	2.7	-0.4	-0.8	0.6	-1.6	-1.1	0.7	-0.6	0.2	0.9
Medication: Blood pressure	1.8	3.1	9.9	1.5	1.4	-1.2	-3.1	1.6	-2.0	1.4	-2.0	0.5
Angina (self-reported)	0.5	0.6	1.2	-1.0	-1.0	0.9	-0.5	0.0	0.1	-0.9	1.1	-0.8
Migraine (self-reported)	0.4	0.5	2.0	-1.1	-0.2	0.1	1.4	0.2	-0.5	-0.4	-0.0	0.9
Medication: Ibuprofen	0.3	0.4	1.4	0.5	-0.2	-0.2	1.2	0.1	0.2	0.6	-0.6	-0.9
Medication: Allopurinol	0.8	1.0	6.2	-0.4	0.4	-0.7	-2.5	0.7	-0.2	1.0	-0.1	-0.9
Medication: Omeprazole	1.5	1.8	5.0	-0.7	-0.7	1.5	-1.2	-1.0	1.2	-1.7	2.2	1.3
Medication: Seretide 50 evohaler	0.2	0.3	0.9	1.0	-0.3	0.3	0.0	-0.5	0.3	-0.2	0.1	0.9
Mean time to correctly identify matches	1.7	3.2	14.0	1.1	-1.8	1.7	0.7	-1.5	1.0	-1.8	0.0	3.7
Heart disease (mother)	0.1	0.1	0.7	-0.4	-0.8	0.1	-0.1	0.1	0.0	-0.0	0.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	4.0	-0.5	0.1	0.5	0.7	-0.2	0.7	0.2	-2.0	0.7
Whole body fat mass	0.2	1.0	3.1	-1.2	0.4	-0.9	0.8	1.4	-1.8	0.5	0.3	-0.8
Leg fat mass (right)	0.2	0.7	2.3	-0.8	0.3	-0.8	0.4	1.4	-1.5	0.5	0.4	-0.4
Arm predicted mass (right)	0.2	1.0	2.6	-1.2	-0.2	-0.5	-0.4	1.3	-1.2	0.3	-1.2	-1.6
Pulse rate, automated reading	0.3	0.8	2.2	-0.1	-1.0	1.5	0.2	-1.2	1.0	-1.1	0.8	-0.3
Alcohol intake frequency.	0.6	1.4	3.7	-0.8	-1.9	1.3	-0.0	-1.1	1.0	-1.0	1.4	1.1
Comparative height size at age 10	0.3	1.4	2.9	-1.4	-1.7	1.5	0.7	-0.7	0.9	-1.6	0.8	0.6
Number of full sisters	0.5	0.6	1.6	-0.5	0.8	-0.5	-0.1	0.9	0.2	0.7	-1.3	-1.1
Suffer from ‘nerves’	0.4	0.7	2.9	-1.7	-0.6	0.7	0.4	-0.9	0.3	-1.0	0.3	-0.2
Overall health rating	0.3	0.7	1.4	-0.3	-0.8	1.1	0.3	-0.9	1.0	-1.0	-1.2	0.4
Chest pain or discomfort	0.3	0.4	1.5	1.2	0.2	0.0	-1.1	0.3	-0.6	-0.1	-0.6	0.6
Had major operations	1.2	1.4	2.8	-1.0	-1.4	1.2	-1.7	-1.1	1.2	-1.1	1.2	0.4
Age at last live birth	0.4	0.5	2.0	1.4	0.2	-0.5	0.1	0.4	-0.1	0.7	-0.8	-1.1
Family relationship satisfaction	2.0	2.4	6.6	1.3	1.1	-1.5	1.0	1.8	-2.6	1.7	-1.1	-1.2
Leg pain on walking	1.2	1.5	2.9	0.6	1.3	-1.7	-0.0	1.5	-1.3	1.6	-1.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.2	-0.0	0.9	-1.3	-0.4	1.3	-0.9	1.1	-0.9	-2.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.6	-0.4	-1.0	0.7	-0.3	-0.5	0.3	-1.2	1.9	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	-0.7	0.2	0.2	0.4	-0.1	-0.4	-0.3	-0.5	-0.4
Medication: Aspirin	0.8	1.0	3.0	1.2	0.3	-0.9	-0.4	1.4	-1.7	1.1	0.3	0.6
Supplements: Vitamin C	0.8	0.9	1.8	0.2	1.0	-1.1	1.4	0.3	-1.1	1.1	-0.4	-1.2
Knee pain experienced in last month	0.3	0.4	3.1	-0.2	0.2	-0.3	-0.5	0.5	0.3	0.1	-1.8	-0.3
Hypertension (Self-reported)	0.9	2.5	6.4	1.6	1.2	-1.0	-2.0	1.2	-2.0	0.9	-2.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.4	0.7	-0.4	-0.5	0.3	0.4	0.6	0.5	-0.1
Illnesses of father: Heart disease	0.3	0.4	1.2	0.0	0.5	-0.6	-0.8	1.1	-0.2	0.3	-0.5	0.6
Illnesses of siblings: Diabetes	2.1	2.5	4.5	0.5	2.0	-2.1	-0.5	2.0	-1.7	1.9	-1.2	-1.4
Smoking status: Previous	0.6	0.9	3.2	0.4	-0.1	-0.9	1.8	1.1	-1.1	0.8	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	5.0	-0.1	0.6	-1.0	1.7	1.0	-1.2	1.1	-1.2	-2.2
Whole body fat-free mass	0.2	1.2	4.2	-2.0	-0.6	-0.1	-0.2	0.7	-0.7	-0.1	-0.9	-2.0
Leg fat-free mass (right)	0.3	1.6	5.9	-2.4	-0.1	-0.5	0.0	1.0	-0.8	0.3	-1.2	-2.3
Arm fat percentage (left)	0.3	1.1	3.2	-0.8	0.9	-1.4	0.7	1.5	-1.8	1.0	0.3	-0.1
Average weekly red wine intake	0.5	0.8	3.0	-0.0	1.7	-1.1	0.1	0.6	-0.5	1.0	-0.5	-1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	-1.0	1.2	-1.2	-0.1	0.9	-0.3	0.8	0.1	-0.1
Mood swings	1.0	1.8	4.2	-1.5	-1.1	1.4	-1.4	-0.9	2.1	-1.4	1.4	-0.0
Loneliness, isolation	0.3	0.4	1.1	0.1	-0.5	0.6	-0.6	-0.4	0.7	-0.5	1.0	-0.6
Long-standing illness, disability or infirmity	0.6	0.9	2.0	0.3	-1.2	1.0	-1.2	-0.8	0.6	-0.9	-0.0	1.4
Ever had bowel cancer screening	0.2	0.3	0.5	0.7	-0.7	0.5	0.4	-0.2	0.3	-0.6	0.7	-0.4
Diabetes diagnosed by doctor	0.5	0.7	2.7	0.6	-0.6	0.7	-1.7	-0.7	0.9	-0.8	-0.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.7	0.3	-0.5	-0.1	1.6	0.4	-0.0	0.3	-1.5	-0.8
Friendships satisfaction	4.1	5.0	9.5	1.7	2.4	-2.5	1.0	2.2	-2.8	2.4	-3.1	-1.3
Qualifications: nursing, teaching	0.7	1.0	2.3	0.6	1.3	-1.0	-1.5	0.7	-1.1	1.4	0.1	-0.2
Commuting to job workplace: Walk	0.5	0.5	1.5	-1.2	0.5	-0.4	0.9	0.2	-0.4	0.8	-0.6	-1.0
Eye problems/disorders: Cataract	1.7	2.0	6.2	0.1	1.8	-1.1	-2.5	1.3	-1.8	1.3	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.2	0.7	0.8	-0.9	1.5	0.9	0.2	0.8	-1.2	-1.5
Medication for cholesterol	0.8	1.2	2.5	-0.9	1.4	-1.6	0.0	1.2	-1.1	1.5	0.0	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	0.0	-0.3	0.5	-1.5	-0.9	1.2	-0.6	0.1	1.1
Back pain experienced in last month	0.4	0.6	2.5	-0.1	0.5	-0.8	0.2	0.5	-1.6	0.9	-0.9	-0.7
Mineral and other dietary supplements	0.3	0.3	0.8	-0.9	0.9	-0.6	-0.3	0.5	0.7	-0.0	-0.6	-0.4
Breast cancer (self-reported)	0.4	0.5	1.9	0.3	-0.1	0.0	0.2	0.5	-1.0	-0.4	1.4	-0.9
Asthma (self-reported)	0.4	0.8	3.4	1.8	0.8	-0.8	0.4	0.6	-0.3	0.7	-1.0	0.8
Osteoporosis (self-reported)	0.7	0.9	3.5	-0.4	-0.5	0.5	1.9	-1.2	0.4	-0.5	1.2	0.6
Osteoarthritis (self-reported)	0.2	0.3	1.5	1.2	0.2	0.3	0.1	-0.0	-0.3	-0.2	0.6	-0.5
Medication: Aspirin	0.8	1.1	2.9	0.9	0.2	-0.8	-1.0	1.3	-1.7	1.0	0.7	0.9
Medication: Gliclazide	0.7	0.8	2.3	1.2	-0.6	0.7	1.5	-0.7	0.7	-0.5	0.6	0.9
Illnesses of father: None of the above (group 1)	0.4	0.6	2.0	-0.7	-0.6	0.5	1.4	-0.9	0.3	-0.2	0.3	-0.9
Smoking status: Current	0.2	0.4	1.0	0.7	0.3	0.1	-0.9	-0.2	0.6	-0.3	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	2.2	-1.0	-1.0	1.1	-1.5	-1.0	1.5	-1.0	0.7	0.3
Whole body water mass	0.2	1.3	4.9	-1.9	-0.4	-0.2	-0.3	0.9	-0.9	0.1	-0.9	-2.2
Leg predicted mass (right)	0.3	1.6	5.9	-2.4	-0.1	-0.5	0.0	1.1	-0.8	0.3	-1.2	-2.3
Arm fat mass (left)	0.4	1.6	4.6	-1.1	0.9	-1.5	0.2	1.8	-2.1	1.1	0.1	-1.1
Number of self-reported non-cancer illnesses	3.2	5.5	8.9	-0.8	-3.0	2.7	-0.4	-3.0	1.9	-2.8	3.0	1.9
Average weekly champagne plus white wine intake	1.7	2.3	4.4	0.4	2.0	-2.1	-0.9	1.8	-1.5	2.0	-0.4	-1.2
Miserableness	0.4	0.7	1.8	-1.4	0.2	0.9	-0.3	-0.6	1.3	-0.5	-1.1	-0.2
Guilty feelings	0.7	1.0	2.0	-0.9	-1.4	1.2	-0.2	-1.1	1.3	-1.0	0.5	-0.6
Wears glasses or contact lenses	1.9	2.2	4.5	-0.7	-1.2	1.4	-0.5	-1.7	1.9	-1.5	2.1	1.6
Ever taken oral contraceptive pill	1.6	1.7	6.1	1.7	1.6	-1.4	0.7	0.9	0.0	1.1	-2.5	0.2
Hearing aid user	0.9	1.0	3.5	-0.3	-0.9	1.0	1.0	-0.6	0.4	-0.9	1.9	0.9
Mother’s age at death	0.2	0.2	0.9	0.1	-0.1	0.4	0.1	-0.6	0.4	-0.4	-0.0	1.0
Financial situation satisfaction	0.7	0.9	3.5	1.9	0.8	-0.9	0.4	1.3	-0.5	0.8	-0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.1	-1.1	-1.0	0.7	-0.1	-0.5	0.3	-0.7	0.2	-0.2
Commuting to job workplace: Public transport	1.9	2.2	5.1	0.9	2.1	-1.7	0.0	1.1	-1.0	1.7	-2.3	-1.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.5	-0.4	0.2	0.5	-0.1	-0.5	-0.1	0.1	0.6
Medication: Blood pressure	0.7	1.3	3.9	-0.2	0.6	-0.8	-1.4	1.1	-0.6	0.5	-1.6	-2.0
Pain type(s) experienced in last month: Hip pain	1.2	1.5	1.9	-1.1	-1.4	1.3	1.4	-1.0	0.9	-1.3	1.3	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.8	1.1	-1.3	1.1	0.3	-0.9	0.2	-0.2	0.2	0.2
High cholesterol (Self-reported)	2.2	3.8	6.4	1.7	-2.3	2.5	0.2	-2.2	1.3	-2.3	1.4	2.4
Medication: Bendroflumethiazide	2.4	3.7	6.9	1.8	1.6	-2.0	-2.6	2.1	-1.2	2.0	-2.2	-1.3
Medication: Paracetamol	0.7	1.0	4.5	0.1	0.7	-0.8	-0.4	1.1	-2.1	1.1	-0.8	-0.7
Medication: Lisinopril	0.7	0.9	4.3	0.0	-0.8	0.6	-2.1	-0.6	0.4	-0.8	0.8	1.1
Medication: Atorvastatin	0.3	0.4	2.4	-0.6	0.0	0.4	-1.6	-0.6	0.2	-0.2	0.2	0.6
Illnesses of father: High blood pressure	0.5	0.6	4.3	-0.0	-0.1	0.2	-2.1	0.3	-0.8	-0.1	-0.2	0.2
Alcohol drinker status: Never	0.2	0.3	0.8	0.4	0.6	-0.5	-0.1	0.9	-0.2	0.6	-0.1	-0.5
Ever smoked	0.1	0.2	1.2	0.4	-0.5	-0.3	1.1	0.0	0.6	-0.0	0.2	0.1
Basal metabolic rate	0.2	1.2	4.5	-1.8	-0.2	-0.5	-0.1	1.1	-1.0	0.3	-0.8	-2.1
Leg fat percentage (left)	0.2	0.6	1.7	0.0	0.3	-0.8	0.9	1.2	-1.3	0.4	0.8	-0.3
Arm fat-free mass (left)	0.2	1.1	4.5	-1.6	-0.5	-0.2	-0.3	1.1	-1.1	-0.0	-0.8	-2.1
Number of operations (self-reported)	1.8	2.6	5.4	0.3	-1.8	2.3	0.2	-1.8	2.1	-2.2	0.4	1.4
Average weekly beer plus cider intake	0.4	0.5	2.1	-0.2	-0.8	0.7	-0.1	-0.4	0.7	-0.8	-1.5	0.1
Irritability	0.2	0.3	0.8	-0.0	-0.4	0.5	-0.7	-0.4	0.9	-0.4	-0.7	-0.0
Risk taking	0.1	0.2	1.0	0.3	-0.2	0.3	-0.0	-0.2	1.0	-0.4	-0.3	0.3
Ever had prostate specific antigen (PSA) test	1.0	1.1	4.4	0.2	-1.1	0.9	-0.1	-1.1	1.1	-0.7	0.8	2.1
Fractured/broken bones in last 5 years	0.9	1.2	2.8	-1.7	-1.4	0.7	0.8	-1.5	0.8	-1.1	0.8	0.2
Age started oral contraceptive pill	0.2	0.3	0.6	0.6	0.7	-0.8	-0.0	0.6	-0.5	0.2	0.5	0.6
Diastolic blood pressure, automated reading	0.5	1.4	4.0	-0.5	1.1	-0.7	-0.6	0.8	-2.0	0.9	-1.5	-1.7
Ever depressed for a whole week	0.2	0.3	0.5	-0.4	0.6	-0.7	-0.5	0.4	-0.7	0.5	0.3	-0.1
Unable to work because of sickness or disability	0.5	0.7	2.7	-1.0	0.5	-0.5	-1.6	0.4	-0.9	0.7	0.2	-0.8
Commuting to job workplace: Cycle	0.7	0.9	3.6	-1.6	0.3	-0.6	-0.6	-0.2	0.8	0.1	0.4	-1.9
Myopia	0.3	0.4	2.0	0.5	0.2	-0.4	0.6	0.5	-1.4	0.6	0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.6	-1.5	-1.0	1.0	2.1	-1.2	1.7	-0.8	1.9	0.8
Cholesterol lowering medication	2.3	3.3	5.7	0.4	-2.3	2.4	-0.7	-2.0	1.0	-2.1	2.0	2.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.2	-0.1	-0.6	1.2	-0.6	-0.9	0.5	-1.3	1.8	1.3
Pain experienced in last month	0.4	0.7	1.3	-0.0	1.2	-1.0	-0.9	0.9	-0.6	1.0	0.6	-0.8
Supplements: Calcium	1.7	1.8	3.4	0.8	-1.7	1.3	1.9	-1.7	1.4	-1.0	0.4	1.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.3	0.1	0.0	0.8	0.5	-0.6	-0.1	0.2	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.2	0.5	0.4	-0.2	1.5	0.4	-0.9	0.3	-0.6	0.9
Deep venous thrombosis (DVT) (self-reported)	9.1	11.7	22.7	-3.1	-4.8	4.1	0.3	-4.2	3.2	-3.8	2.9	2.2
Heart disease (siblings)	0.5	0.6	2.2	-0.5	-1.0	0.6	1.5	-0.5	0.8	-0.6	-0.1	0.1
Alcohol drinker status: Previous	3.5	4.0	6.9	-2.6	-2.6	2.1	-0.9	-2.1	1.8	-1.9	1.2	2.0
Pack years of smoking	1.2	1.7	7.1	0.4	-1.2	1.5	0.4	-1.1	0.9	-1.5	-0.3	2.7
Impedance of whole body	0.2	1.2	6.6	1.1	1.0	-0.6	2.6	-0.4	-0.0	0.4	1.0	0.5
Leg fat mass (left)	0.2	0.8	2.4	-0.7	0.5	-1.0	0.5	1.5	-1.6	0.6	0.1	-0.7
Arm predicted mass (left)	0.2	1.0	4.5	-1.3	-0.5	-0.3	-0.3	1.1	-1.1	0.1	-0.5	-2.1