Best TWAS P=1.57e-36 · Best GWAS P=2.59e-36 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-298P3.4 | 0.09 | 0.01 | lasso | 7 | 0.00 | 1.9e-01 | 8.50 | 9.2 | 2.3e-20 | 0.84 | 0.07 | 0.84 | FALSE |
2 | GTEx | Artery Aorta | N4BP2L2 | 0.13 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | 12.47 | 12.4 | 4.1e-35 | 0.97 | 0.02 | 0.98 | FALSE |
3 | GTEx | Nerve Tibial | RP11-298P3.4 | 0.06 | 0.01 | enet | 19 | 0.01 | 7.8e-02 | 8.90 | 7.1 | 1.0e-12 | 0.66 | 0.12 | 0.56 | FALSE |
4 | GTEx | Whole Blood | KL | 0.12 | 0.00 | lasso | 7 | 0.00 | 4.9e-01 | 0.25 | -7.4 | 1.6e-13 | -0.58 | 0.13 | 0.12 | FALSE |
5 | YFS | Blood | KL | 0.05 | 0.01 | blup | 522 | 0.04 | 7.6e-13 | 8.44 | -5.2 | 2.2e-07 | -0.50 | 0.13 | 0.87 | FALSE |
6 | YFS | Blood | PDS5B | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.4e-11 | 8.74 | 8.7 | 2.4e-18 | 0.82 | 0.37 | 0.63 | FALSE |
7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CG030 | 0.06 | 0.01 | blup | 38 | 0.03 | 6.0e-04 | -9.01 | -11.0 | 5.2e-28 | -0.83 | 0.02 | 0.77 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CG030 | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.1e-04 | 12.47 | -12.4 | 2.5e-35 | -0.97 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | N4BP2L2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.4e-03 | 12.58 | 12.6 | 1.6e-36 | 1.00 | 0.00 | 0.97 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CG030 | 0.07 | 0.02 | lasso | 4 | 0.03 | 2.4e-04 | 12.15 | -10.4 | 2.4e-25 | -0.83 | 0.01 | 0.62 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | N4BP2L2 | 0.04 | 0.03 | blup | 69 | 0.02 | 9.4e-04 | 12.47 | 11.9 | 2.0e-32 | 0.96 | 0.01 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CG030 | 0.06 | 0.01 | blup | 38 | 0.02 | 1.9e-03 | -8.34 | -10.4 | 2.6e-25 | -0.82 | 0.03 | 0.82 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | N4BP2L2 | 0.10 | 0.10 | lasso | 4 | 0.11 | 5.2e-12 | 12.47 | 12.5 | 1.3e-35 | 0.97 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | N4BP2L2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 2.8e-03 | 12.56 | 12.1 | 1.3e-33 | 0.89 | 0.01 | 0.96 | FALSE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | N4BP2L2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | 12.58 | 12.3 | 9.9e-35 | 0.99 | 0.00 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CG030 | 0.08 | 0.04 | blup | 38 | 0.04 | 1.4e-03 | 12.15 | -11.3 | 1.6e-29 | -0.92 | 0.00 | 0.92 | FALSE |
17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CG030 | 0.12 | 0.02 | blup | 38 | 0.03 | 3.1e-02 | 11.52 | -9.1 | 7.2e-20 | -0.81 | 0.00 | 0.60 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | N4BP2L2 | 0.06 | 0.03 | lasso | 3 | 0.05 | 1.0e-05 | -4.96 | 8.4 | 4.8e-17 | 0.79 | 0.03 | 0.96 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | EEF1DP3 | 0.05 | 0.00 | blup | 99 | 0.01 | 7.1e-02 | -1.79 | -5.1 | 3.0e-07 | 0.03 | 0.02 | 0.14 | TRUE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | N4BP2L2 | 0.12 | 0.14 | enet | 7 | 0.16 | 1.1e-15 | 11.59 | 12.3 | 6.9e-35 | 0.98 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | PDS5B | 0.02 | 0.01 | blup | 78 | 0.02 | 1.2e-02 | 12.30 | -11.0 | 2.2e-28 | -0.93 | 0.02 | 0.78 | FALSE |