TWAS hub - CCDC75

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.1120	0.048	0.00058	0.036	0.050	0.053	NA	0.052	0.00046	4.3e-05	2.8e-05	NA	3.4e-05
2	TCGA	Breast Invasive Carcinoma	0.0178	0.011	0.00880	0.010	0.010	0.002	NA	0.009	0.00280	3.3e-03	9.3e-02	NA	5.7e-03
3	TCGA	Glioblastoma Multiforme	0.1200	0.062	0.00700	-0.008	0.064	0.002	NA	0.010	0.70000	5.3e-03	2.7e-01	NA	1.6e-01
4	TCGA	Liver Hepatocellular Carcinoma	0.2350	0.089	0.00092	0.000	0.057	0.050	NA	0.030	0.32000	1.2e-03	2.1e-03	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Medication for hormone replacement therapy	4.6	5.1	15.5	1.1	3.9	1.3	1.5
Cholesterol lowering medication	4.2	6.1	14.1	2.3	2.1	-1.0	3.8
Supplements: Fish oil (including cod liver oil)	3.8	5.0	13.5	-0.2	-2.4	-3.7	-0.8
Neck or shoulder pain in last month	3.6	5.1	10.2	-3.2	-1.1	0.7	-2.9
Mineral and other dietary supplements	3.4	4.5	8.6	0.6	2.9	2.8	1.1
Fasting Glucose	3.3	3.9	11.0	-2.0	-0.8	0.3	-3.3
Ever taken oral contraceptive pill	2.9	3.2	6.1	1.2	0.2	-2.5	2.3
Back pain experienced in last month	2.6	3.7	7.5	-1.5	2.7	0.4	-2.2
Ever used hormone-replacement therapy (HRT)	2.5	3.2	6.8	1.6	2.6	0.4	1.8
Birth weight of first child	2.5	4.5	9.3	3.0	1.3	0.7	2.6
Medication for cholesterol	2.5	3.8	11.8	-0.9	-3.4	-0.4	-1.6
Serious illness, injury or assault to yourself	2.4	2.9	6.2	2.0	1.2	-0.4	2.5
Prospective memory result	2.4	2.9	6.3	-1.5	0.5	1.7	-2.5
Medication: Aspirin	2.4	3.2	7.3	2.1	0.4	-0.8	2.7
Number of live births	2.3	3.2	5.2	-1.2	-2.3	-2.2	-1.2
Number of full brothers	2.3	2.9	6.9	-2.6	-1.3	1.7	-0.5
Qualifications: nursing, teaching	2.3	3.5	6.8	2.6	2.3	0.8	1.2
Eye problems/disorders: None of the above	2.2	2.5	3.9	0.9	2.0	1.4	-1.8
Commuting to job workplace: Walk	2.2	2.3	3.2	-1.7	-0.9	1.6	-1.8
Hearing difficulty/problems with background noise	2.1	3.3	4.4	-1.8	-2.1	-1.5	-1.8
Hayfever/allergic rhinitis (self-reported)	2.1	2.7	7.1	-2.7	-1.4	-0.1	-1.3
Medication: Seretide 50 evohaler	2.1	2.5	5.1	2.2	1.6	-0.6	1.4
Ulcerative Colitis	2.0	2.9	6.6	2.6	1.7	-1.4	0.4
Medication: Gliclazide	1.9	2.1	6.4	1.1	-0.0	-1.0	2.5
Schizophrenia (2014)	1.8	3.9	5.8	2.4	1.7	2.0	-1.8
Breast cancer (self-reported)	1.8	2.1	3.6	1.5	1.4	0.8	1.9
Neuroticism (2016)	1.7	2.5	5.6	-2.4	-1.6	1.0	-0.8
Average weekly spirits intake	1.7	2.1	4.3	2.1	1.4	-1.1	0.9
Taking other prescription medications	1.7	2.6	9.4	-0.1	-0.4	0.8	3.1
Time employed in main current job	1.7	1.9	4.3	-1.8	-0.0	-0.5	-2.1
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.8	2.0	1.0	-1.6	0.6
Illnesses of father: Heart disease	1.7	2.4	4.9	1.4	1.0	-2.2	1.4
Smoking status: Previous	1.7	2.6	8.2	-0.4	1.4	2.9	0.5
Alcohol drinker status: Never	1.7	2.1	3.6	1.1	1.6	1.0	1.9
Schizophrenia (2018)	1.6	3.3	4.6	1.8	2.1	1.9	-1.3
Major Depression (MDD)	1.6	2.0	3.7	0.5	1.9	1.9	0.6
Diabetes (mother)	1.6	2.0	4.0	-2.0	-0.5	2.0	-0.4
Medication: Levothyroxine sodium	1.6	2.7	5.5	2.3	0.5	-1.3	1.9
Past tobacco smoking	1.6	2.9	8.0	0.2	-1.6	-2.8	-1.0
Medication: Ramipril	1.6	2.0	4.5	1.4	1.1	-0.3	2.1
Heart disease (mother)	1.6	2.0	5.9	0.0	2.4	1.2	0.8
Eye problems/disorders: Cataract	1.6	1.8	3.6	-1.9	-1.6	-0.5	0.8
Ever depressed for a whole week	1.6	2.0	6.8	-0.7	0.6	2.6	-0.4
Bipolar Disorder or Schizophrenia	1.5	3.7	6.4	1.3	1.8	2.5	-1.9
Blood Platelet Count	1.5	17.6	36.7	-1.2	6.1	5.6	-1.2
Number of incorrect matches in round	1.5	2.5	5.9	-0.6	0.0	2.4	-2.0
Medication: Simvastatin	1.5	2.2	3.8	1.2	0.0	-1.9	2.0
Alcohol intake versus 10 years previously	1.5	2.2	5.0	1.1	0.8	2.2	1.4
Exposure to tobacco smoke at home	1.5	1.6	2.6	1.5	1.6	1.2	-0.5
Osteoarthritis (self-reported)	1.5	2.0	6.1	-2.5	-1.1	0.3	-0.7
Pain experienced in last month	1.5	2.4	6.7	2.6	0.3	-0.6	1.6
Relative age voice broke	1.4	2.2	4.8	-1.3	-2.2	-0.3	-1.5
Diabetes (self-reported)	1.4	2.2	8.5	0.2	0.5	0.3	2.9
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	2.7	-1.6	-1.3	-1.2	1.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	7.1	2.7	0.0	-1.0	1.7
Medication: Aspirin	1.4	1.8	3.8	1.7	0.5	-0.4	1.9
Alcohol drinker status: Previous	1.4	1.6	3.6	-0.8	-0.9	1.2	-1.9
Angina	1.3	1.7	3.0	-0.8	1.2	1.7	1.4
Medication: Metformin	1.3	1.8	5.4	0.9	-0.9	-0.4	2.3
Mouth/teeth dental problems	1.3	1.9	4.0	0.2	2.0	1.2	-1.5
Worrier / anxious feelings	1.3	2.5	7.6	-0.8	-0.8	-1.2	-2.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.9	0.3	-1.7	0.4	-1.7
Worry too long after embarrassment	1.3	2.2	4.1	-2.0	-1.7	-0.4	-1.4
Angina (self-reported)	1.3	1.7	3.4	-0.8	1.3	1.9	1.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.8	-0.6	1.5	1.7	-0.9
Irritability	1.3	2.3	7.3	-2.7	-1.0	-0.4	-0.7
Prostate Cancer	1.2	1.6	3.1	-0.7	0.1	1.8	-1.7
Smoking Status	1.2	2.9	6.4	0.5	1.6	2.5	1.6
Type 2 Diabetes (T2D) (2018)	1.2	2.3	7.8	0.5	0.4	-1.0	2.8
Length of working week for main job	1.2	1.4	2.6	1.6	0.6	-1.1	1.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.7	-1.6	0.3	1.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	4.0	1.4	1.9	2.0	0.6
Diabetes diagnosed by doctor	1.2	1.9	7.2	0.6	-0.1	-0.3	2.7
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.7	1.1	1.7	-0.9	1.1
Neuroticism	1.1	2.6	5.1	-1.9	-2.3	-0.6	-1.2
Neuroticism score	1.1	2.3	3.9	-2.0	-1.1	-0.6	-1.9
Illnesses of mother	1.1	1.4	3.4	1.0	-1.8	-0.2	1.0
Blood clot in the leg (DVT)	1.1	1.4	2.6	1.1	-0.0	-1.4	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.9	0.1	1.5	1.7	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.0	-1.2	-1.4	1.2	0.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.1	-0.2	-1.3	-1.2	1.5
Supplements: Zinc	1.0	1.1	3.4	0.2	0.5	1.8	0.8
Townsend deprivation index at recruitment	1.0	1.4	2.4	-1.6	-1.3	-0.3	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.0	0.9	1.0	2.0	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	5.4	1.0	0.4	1.6	2.3
Medication: Cholesterol lowering	1.0	1.5	2.5	1.1	1.2	-1.6	0.9
Medication: Ibuprofen	1.0	1.2	2.0	-1.4	-1.1	-0.8	1.0
Medication: Omeprazole	1.0	1.2	1.8	-0.9	-1.2	-0.9	1.4
Chest pain or discomfort	1.0	1.4	1.6	1.3	1.0	-1.1	1.3
Medication: Atorvastatin	1.0	1.2	2.7	0.0	1.1	-0.9	1.6
Unable to work because of sickness or disability	1.0	1.3	2.9	0.0	0.7	1.7	-1.3
Alzheimer’s Disease (in father)	0.9	1.0	2.4	-1.2	0.3	1.6	-0.1
HDL Cholesterol	0.9	1.5	3.5	0.5	1.2	1.0	1.9
Blood Red Count	0.9	8.9	19.8	0.9	3.8	4.4	0.6
Allergy or Eczema	0.9	2.3	4.0	-1.5	2.0	0.9	-1.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.3	1.8	0.0	-0.2	1.1
Fed-up feelings	0.9	1.6	4.8	-0.5	0.5	-1.1	-2.2
High blood pressure (mother)	0.9	1.2	2.6	-1.6	1.4	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.8	-0.2	-0.6	-1.9	-0.6
Illnesses of siblings: Diabetes	0.9	1.1	3.6	-0.8	-1.9	0.1	0.3
Long-standing illness, disability or infirmity	0.9	1.3	2.1	0.8	1.2	1.5	1.0
Number of self-reported non-cancer illnesses	0.9	1.5	3.8	-0.0	0.8	1.3	1.9
Miserableness	0.9	1.6	2.3	-1.5	-1.5	-1.4	-0.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.4	-0.3	-1.5	-1.3	-0.3
Ever smoked	0.9	1.6	3.5	0.3	1.4	1.9	1.1
Bipolar Disorder (2018)	0.8	1.2	2.9	-0.2	0.2	1.7	-1.4
Crohns Disease (2017)	0.8	1.8	4.0	-0.5	2.0	1.6	-0.6
Irritable Bowel Disease (IBD)	0.8	1.9	5.5	0.6	2.3	1.3	-0.5
Body Mass Index (BMI) (2010)	0.8	1.2	1.9	1.4	0.7	-0.7	1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.9	0.4	0.0	-1.4	1.2
Vitamin and mineral supplements	0.8	1.1	1.4	1.0	1.1	1.2	0.8
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.1	-1.4	1.4	1.8	-0.4
Supplements: Glucosamine	0.8	1.1	3.3	0.4	-0.9	-1.8	-0.4
Nervous feelings	0.8	1.5	3.3	-1.8	-1.4	-0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.3	-1.5	-1.0	-0.2	-1.2
Illnesses of siblings	0.8	1.1	1.9	0.8	0.2	1.4	-1.3
Mouth/teeth dental problems: Dentures	0.8	1.4	2.4	-0.8	-1.6	0.6	1.4
Breastfed as a baby	0.8	0.9	2.0	0.5	0.3	-1.2	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.4	1.2	0.8	1.2	1.2
Age at first live birth	0.8	1.4	3.0	-0.6	-1.7	1.4	-0.3
Medication: Allopurinol	0.8	1.1	3.3	0.6	1.8	-0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.6	-1.2	-1.2	-0.8	0.4
Average weekly red wine intake	0.8	1.2	3.6	0.1	-1.0	-1.9	0.5
Ever had bowel cancer screening	0.8	1.0	3.6	-0.3	-1.9	-0.4	0.0
Friendships satisfaction	0.8	1.0	1.5	-0.1	1.2	1.0	1.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.5	-0.9	-1.6	-1.4	-0.3
Wears glasses or contact lenses	0.8	0.9	1.6	0.8	-0.6	-1.3	0.9
High cholesterol (Self-reported)	0.8	1.4	3.7	0.9	0.6	-0.8	1.9
Illnesses of father: High blood pressure	0.8	1.0	2.5	0.4	0.9	1.6	0.8
Number of treatments/medications taken	0.7	1.3	4.7	0.5	0.4	-0.4	2.2
Maternal smoking around birth	0.7	1.0	3.0	-0.5	-0.5	1.7	0.7
Stomach or abdominal pain in last month	0.7	0.9	2.4	-1.6	-1.0	-0.3	-0.3
Alcohol usually taken with meals	0.7	1.1	3.5	0.3	0.8	-1.9	-0.2
Fluid intelligence score	0.7	1.5	3.3	1.5	0.2	-0.6	1.8
Noisy workplace	0.7	0.8	2.0	-1.4	-0.9	0.6	-0.3
Loud music exposure frequency	0.7	0.8	1.8	-0.3	0.6	1.3	0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.4	1.1	-0.3	-1.2	1.1
Gout (self-reported)	0.7	0.9	2.5	0.5	0.7	-1.6	0.7
Shortness of breath walking on level ground	0.7	0.8	1.3	-1.1	0.7	0.7	-0.9
Medication: Blood pressure	0.7	1.2	2.1	0.7	1.4	-1.4	0.5
Migraine (self-reported)	0.7	0.9	2.1	-1.4	0.1	0.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.7	-0.4	-1.6	-0.6	0.0
Illnesses of father: None of the above (group 1)	0.7	0.9	2.1	-0.8	-0.8	1.4	-0.4
Commuting to job workplace: Public transport	0.7	0.9	3.0	-0.5	0.5	1.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.8	0.4	1.4	1.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.5	1.0	-0.2	-1.2	1.1
HbA1C	0.6	0.7	1.8	-1.0	0.2	0.1	1.3
Systolic Blood Pressure	0.6	2.9	6.9	-2.6	1.3	-1.7	-0.4
Lung FVC	0.6	3.2	7.0	1.3	2.6	2.0	0.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.0	-0.7	0.0	-0.1	-1.7
Systolic blood pressure, automated reading	0.6	1.7	3.6	-1.7	-0.5	-1.9	-0.1
Medication: Co-codamol	0.6	0.7	1.5	0.3	1.2	0.4	1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	0.9	0.4	-0.5	1.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-0.9	0.7	1.2	0.2
Forced vital capacity (FVC)	0.6	2.1	3.2	1.0	1.4	1.8	1.6
Financial difficulties in last 2 years	0.6	0.7	1.5	-0.5	1.2	-1.1	-0.1
Allergy	0.6	1.4	2.3	1.2	-1.5	-1.3	-0.4
Father’s age at death	0.6	0.8	1.6	0.8	0.7	-0.6	1.3
Pulse wave reflection index	0.6	0.8	1.7	1.3	0.5	-0.8	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.8	-0.8	-1.3	1.2	-0.6
Medication: Amlodipine	0.6	0.8	1.3	-0.7	1.2	-1.1	-0.6
Exposure to tobacco smoke outside home	0.6	0.9	2.1	-0.4	1.0	1.4	-0.5
Comparative body size at age 10	0.6	1.7	4.8	1.3	2.2	0.4	0.2
Age at last live birth	0.6	0.8	2.9	-0.3	-1.7	0.3	-0.4
Mother’s age at death	0.6	0.8	1.3	-0.8	-1.1	0.2	-1.0
Medication: Paracetamol	0.6	1.0	1.6	-1.3	-0.7	0.5	-1.2
Fractured/broken bones in last 5 years	0.6	0.8	1.3	-0.9	-1.1	-0.9	0.5
Neuroticism (Nagel 2018)	0.5	1.2	1.4	-1.2	-1.0	-0.9	-1.2
Age at First Birth	0.5	0.7	2.1	-0.3	0.1	1.4	-0.7
Crohns Disease (2012)	0.5	0.7	1.5	-1.0	0.1	1.2	0.7
Rheumatoid Arthritis	0.5	0.7	2.6	-0.3	-0.2	0.4	-1.6
Triglycerides	0.5	0.8	2.3	0.0	-1.5	-0.8	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.0	0.9	-0.4	-1.0	0.5
Blood Eosinophil Count	0.5	4.0	10.2	-1.9	1.3	3.2	-0.8
Cardiovascular Disease	0.5	1.5	3.7	-0.8	0.9	-0.9	1.9
Chronotype (morning person)	0.5	1.1	1.8	0.5	-1.1	-1.4	-1.1
Relative age of first facial hair	0.5	1.0	2.4	-0.9	-0.8	0.0	-1.5
Severe depression (siblings)	0.5	0.6	1.3	-1.1	-0.8	0.4	-0.4
Leg fat-free mass (left)	0.5	2.8	5.3	1.1	2.3	1.6	1.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.6	-0.4	-0.6	-0.4	-1.2
Multivitamins +/- minerals	0.5	0.6	1.2	-0.7	-1.1	-0.9	0.1
Leg predicted mass (left)	0.5	2.5	5.0	0.9	2.2	1.6	1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	-0.7	0.3	0.5	-1.2
Pain all over the body in last month	0.5	0.5	1.4	0.8	-0.1	-0.3	1.2
Falls in the last year	0.5	0.7	1.7	0.1	-1.3	0.4	1.0
Depression (self-reported)	0.5	0.6	1.5	-0.5	0.6	1.2	-0.6
Medication: Paracetamol	0.5	0.8	2.1	-0.9	-0.6	-0.0	-1.4
High blood pressure (siblings)	0.5	0.8	1.1	-0.8	1.0	-0.7	1.0
Number of children fathered	0.5	0.5	1.8	-0.5	0.3	1.4	-0.1
Health satisfaction	0.5	0.7	2.3	-1.5	-0.6	0.1	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	2.5	-0.2	0.8	0.3	-1.6
Pulse rate, automated reading	0.5	1.6	2.8	0.8	-1.7	-1.7	-0.2
Supplements: Vitamin C	0.5	0.5	1.4	-0.4	-0.7	-1.2	-0.4
Leg fat-free mass (right)	0.5	2.7	5.8	0.9	2.4	1.7	1.2
Mood swings	0.5	0.9	2.8	-0.9	0.3	0.2	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-0.7	0.5	0.5	-1.1
Leg predicted mass (right)	0.5	2.8	5.9	0.8	2.4	1.7	1.2
Hearing aid user	0.5	0.5	2.0	0.2	-0.3	0.1	1.4
Medication: Blood pressure	0.5	1.0	3.2	-0.7	1.8	0.2	0.6
Arm fat-free mass (left)	0.5	2.5	6.2	1.3	2.5	0.6	1.3
Number of operations (self-reported)	0.5	0.8	2.5	-0.1	-1.6	-0.7	0.4
Diastolic blood pressure, automated reading	0.5	1.7	3.6	-1.6	-0.8	-1.9	-0.3
Basal cell carcinoma (self-reported)	0.5	0.6	2.6	0.0	0.1	-0.2	-1.6
Heart disease (siblings)	0.5	0.7	0.9	-0.9	-0.2	-1.0	0.9
Depressed Affect (Nagel 2018)	0.4	0.9	2.0	-0.3	-0.6	-1.0	-1.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.6	0.1	1.6	1.2	0.7
Ulcerative Colitis (UC)	0.4	0.8	1.9	1.0	1.4	0.2	-0.5
Heel T-Score	0.4	3.0	5.2	1.3	2.3	0.8	2.1
Diabetes (father)	0.4	0.5	2.1	0.2	-0.0	-0.2	1.5
Impedance of leg (right)	0.4	2.0	4.1	-0.1	-2.0	-1.9	-0.5
Medication: Atenolol	0.4	0.5	0.8	-0.4	0.9	-0.7	0.9
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	-0.6	-0.1	-0.9	-0.7
Impedance of leg (left)	0.4	1.7	2.9	-0.3	-1.7	-1.7	-1.0
Heart attack	0.4	0.5	1.4	-1.2	0.7	0.1	0.2
Trunk fat-free mass	0.4	2.4	4.8	1.1	2.2	1.5	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.4	-0.0	-0.2	-1.5	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.2	1.5	0.9	0.7	1.5
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	0.6	-0.6	-0.9	0.4
Trunk predicted mass	0.4	2.5	4.8	1.1	2.2	1.5	1.2
Hair/balding pattern: Pattern 4	0.4	1.0	1.7	-0.0	1.1	-1.3	1.1
Headache pain in last month	0.4	0.6	1.0	-0.9	-0.8	-0.2	1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.8	-0.1	0.4	0.0	1.4
Arm fat-free mass (right)	0.4	2.2	4.8	1.1	2.2	1.5	0.9
Wheeze or whistling in the chest in last year	0.4	0.7	1.2	-0.6	1.1	1.0	0.4
Pulse wave peak to peak time	0.4	0.5	1.0	-0.6	0.7	1.0	-0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	-0.3	-0.4	-1.3	-0.3
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.5	-0.7	0.9	-0.7
Mean time to correctly identify matches	0.4	0.8	2.6	-0.5	0.4	1.6	-0.1
Comparative height size at age 10	0.4	1.9	4.7	2.2	1.1	-0.6	1.2
Family relationship satisfaction	0.4	0.5	1.0	1.0	0.4	-0.7	0.5
Knee pain experienced in last month	0.4	0.7	1.0	-1.0	-1.0	0.0	-0.9
Whole body fat-free mass	0.4	2.5	5.2	1.0	2.3	1.6	1.1
Asthma (self-reported)	0.4	0.8	1.3	-0.4	0.9	1.2	0.9
Smoking status: Current	0.4	0.7	1.1	0.4	0.9	0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.5	1.2	-0.5	-0.4	1.1
Whole body water mass	0.4	2.4	5.0	1.0	2.2	1.5	1.1
Basal metabolic rate	0.4	2.1	4.5	1.0	2.1	1.2	1.3
Average weekly beer plus cider intake	0.4	0.6	1.2	-0.6	-1.1	0.1	0.9
Risk taking	0.4	0.5	0.9	0.3	-1.0	0.6	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	-1.0	0.9	-0.1	0.5
Arm predicted mass (left)	0.4	2.2	5.8	1.1	2.4	0.9	1.1
Worry (Nagel 2018)	0.3	0.7	1.4	-0.6	-0.5	-1.0	-1.2
Reaction Time	0.3	0.6	2.0	0.2	0.3	1.4	0.6
Breast Cancer	0.3	0.7	1.0	-1.0	-0.5	1.0	0.7
Ovarian Cancer	0.3	0.4	1.2	-0.5	0.4	-1.1	-0.4
Coronary Artery Disease (CAD)	0.3	0.4	0.8	-0.3	-0.5	-0.9	0.6
Mean Putamen Volume	0.3	0.4	0.8	-0.4	0.0	-0.8	-0.9
LDL Cholesterol	0.3	0.5	1.1	-0.7	-1.1	-0.5	0.3
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.2	-0.7	-0.9	0.2
Hypothyroidism (self reported)	0.3	0.7	1.1	1.0	-1.1	-0.6	0.5
Hand grip strength (left)	0.3	0.9	1.4	1.1	1.2	0.6	0.7
Sensitivity / hurt feelings	0.3	0.4	1.1	-1.1	0.1	-0.5	-0.6
Hand grip strength (right)	0.3	0.7	1.9	0.9	0.4	0.0	1.4
Average weekly fortified wine intake	0.3	0.3	0.5	0.3	0.7	-0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.8	-0.3	-0.2	0.9
High blood pressure	0.3	0.8	1.5	-1.0	1.2	-0.5	0.6
Sitting height	0.3	2.3	3.0	1.6	1.4	-1.4	1.7
Had menopause	0.3	0.4	1.5	-0.1	0.1	1.2	0.2
Had other major operations	0.3	0.3	0.9	0.2	1.0	-0.5	0.4
Qualifications: None of the above	0.3	0.5	1.2	0.7	1.1	-0.6	0.2
Impedance of arm (right)	0.3	1.2	2.6	-0.5	-1.6	-1.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	-1.1	-0.3	-0.5	-0.4
Happiness	0.3	0.4	0.9	-0.5	0.1	0.7	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.9	0.9	-0.8	-0.4	0.9
Asthma	0.3	0.7	1.0	-0.8	0.4	1.0	1.0
Medication: Lansoprazole	0.3	0.3	0.6	0.8	-0.6	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.7	0.6	1.0	0.7	1.3
Impedance of arm (left)	0.3	1.5	4.2	-0.8	-2.0	-1.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	0.7	0.3	0.6	1.1
Forced vital capacity (FVC), Best measure	0.3	1.0	2.0	0.3	0.9	1.4	1.0
Arm predicted mass (right)	0.3	1.5	3.3	0.9	1.8	1.2	0.6
Suffer from ‘nerves’	0.3	0.5	0.9	-0.5	0.8	-0.9	-0.6
Had major operations	0.3	0.3	0.9	-0.6	-1.0	-0.0	-0.2
Leg pain on walking	0.3	0.4	1.5	-0.2	-0.2	-1.2	0.2
Hypertension (Self-reported)	0.3	0.8	1.3	-1.1	1.0	-0.8	0.4
Loneliness, isolation	0.3	0.4	1.1	-1.0	0.2	0.1	-0.7
Financial situation satisfaction	0.3	0.4	1.0	1.0	0.2	-0.3	0.6
Medication: Lisinopril	0.3	0.3	1.0	-0.6	1.0	-0.1	0.1
Commuting to job workplace: Cycle	0.3	0.3	1.3	0.0	0.1	-1.2	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.0	0.9	-1.0	0.6	-1.0
Impedance of whole body	0.3	1.7	3.6	-0.4	-1.9	-1.7	-0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.5	0.5	0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.1	0.5	-0.1	-0.1	1.5
Blood White Count	0.2	1.7	4.9	1.0	2.2	-0.5	0.8
BMI	0.2	1.1	2.0	0.4	1.4	0.5	1.4
Respiratory disease	0.2	0.4	0.5	-0.7	0.6	0.5	0.6
Lung FEV1/FVC ratio	0.2	1.0	2.0	1.1	0.4	-0.8	1.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.3	0.4	0.9	-0.1
Current tobacco smoking	0.2	0.4	0.8	0.1	0.5	0.6	0.9
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.3	-0.3	0.2	0.8
Waist circumference	0.2	0.9	2.6	0.9	0.4	-0.1	1.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	-0.7	-0.2	-0.5	-0.5
Weight	0.2	0.9	1.6	0.7	1.2	0.4	1.2
Pulse rate	0.2	0.4	0.9	0.6	-0.4	-0.3	-0.9
Lung cancer (father)	0.2	0.3	0.5	-0.5	-0.5	0.3	-0.7
Peak expiratory flow (PEF)	0.2	0.3	0.6	0.4	0.7	-0.3	0.8
Glaucoma (self-reported)	0.2	0.2	0.5	0.5	-0.7	-0.2	0.0
Birth weight	0.2	0.5	1.0	0.2	-0.1	1.0	1.0
Alcohol intake frequency.	0.2	0.6	1.1	1.1	0.7	0.4	0.7
Overall health rating	0.2	0.5	0.8	-0.8	0.9	0.5	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.0	-0.8	0.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	-0.6	0.4	0.3	0.7
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.2	0.2	-0.8	0.2
Average weekly champagne plus white wine intake	0.2	0.3	1.0	0.3	-0.0	-1.0	-0.3
Age started oral contraceptive pill	0.2	0.3	0.6	-0.6	0.3	-0.3	0.8
Myopia	0.2	0.2	0.4	-0.5	-0.1	0.7	-0.5
Supplements: Calcium	0.2	0.3	0.9	-0.3	0.0	-0.2	-0.9
Pack years of smoking	0.2	0.3	0.6	0.8	-0.6	-0.1	0.2
Depression (Nagel 2018)	0.1	0.2	0.4	0.0	0.6	-0.3	-0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	0.1	0.3	-0.0	-0.6
Lupus	0.1	0.2	0.7	-0.3	-0.1	0.8	-0.1
Height	0.1	1.1	2.8	-0.2	1.1	0.6	-1.7
Waist Hip Ratio (WHR)	0.1	0.7	1.4	0.9	-1.2	0.3	0.6
Tanning	0.1	1.5	4.2	0.2	1.2	2.1	0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.4	0.4	0.2	-0.1
Pack years adult smoking proportion	0.1	0.2	0.5	0.4	-0.7	-0.2	-0.1
Body mass index (BMI)	0.1	0.3	0.5	0.2	0.7	0.2	0.7
Trunk fat mass	0.1	0.2	0.7	0.2	0.4	-0.1	0.8
Hip circumference	0.1	0.4	1.0	0.5	0.7	-0.3	1.0
Arm fat mass (right)	0.1	0.5	1.0	0.4	0.8	-0.3	1.0
Standing height	0.1	1.4	2.2	1.2	1.5	0.8	1.1
Tense / ‘highly strung’	0.1	0.2	0.6	-0.8	-0.3	0.4	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.2	-0.2	0.2	-0.6
Leg fat percentage (right)	0.1	0.3	0.7	0.5	-0.2	-0.9	0.4
Qualifications: College or University degree	0.1	0.5	1.1	1.0	0.6	0.6	-0.1
Whole body fat mass	0.1	0.3	0.6	0.5	0.7	-0.0	0.8
Leg fat mass (right)	0.1	0.6	1.0	0.7	1.0	-0.3	0.8
Number of full sisters	0.1	0.2	0.3	0.6	0.0	-0.5	0.1
Arm fat mass (left)	0.1	0.4	1.0	0.3	0.6	-0.1	1.0
Guilty feelings	0.1	0.1	0.4	-0.7	-0.0	-0.2	0.2
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.4	0.7	0.0	0.1
Leg fat mass (left)	0.1	0.6	1.3	0.7	1.1	-0.3	0.6
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.3	0.1	0.0	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.7	2.4	-1.5	-0.4	-0.4	0.4
Trunk fat percentage	0.0	0.1	0.3	-0.2	-0.1	-0.5	0.4
Age when periods started (menarche)	0.0	0.1	0.2	0.2	-0.4	-0.0	-0.4
Arm fat percentage (right)	0.0	0.2	0.4	-0.1	0.0	-0.6	0.5
Body fat percentage	0.0	0.1	0.4	-0.0	-0.3	-0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.4	0.0	0.2	-0.1
Arm fat percentage (left)	0.0	0.1	0.2	-0.2	-0.3	-0.3	0.4
Leg fat percentage (left)	0.0	0.1	0.4	0.3	0.1	-0.7	0.0

Hub : Genes

CCDC75

Models

Trait associations