Hub : Genes

CDC42EP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0290	7.4e-03	0.051	0.009	0.035	0.039	0.043	6.6e-07	2.7e-02	3.9e-05	1.3e-05	5.5e-06
2	GTEx	Cells EBV-transformed lymphocytes	0.3690	0.1160	1.1e-03	-0.007	NA	0.017	NA	0.072	6.7e-01	NA	9.2e-02	NA	2.4e-03
3	GTEx	Cells Transformed fibroblasts	0.1110	0.0450	5.3e-03	0.022	NA	0.011	NA	0.028	8.5e-03	NA	4.7e-02	NA	3.5e-03
4	GTEx	Whole Blood	0.1010	0.0370	2.0e-03	0.010	NA	-0.002	NA	0.000	3.5e-02	NA	5.6e-01	NA	3.4e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0739	0.0299	7.0e-03	0.012	0.017	0.038	0.033	0.031	9.2e-03	2.5e-03	1.1e-05	3.5e-05	6.1e-05
6	YFS	Blood	0.0614	0.0146	2.0e-08	0.055	0.038	0.055	0.054	0.054	1.8e-17	2.1e-12	2.4e-17	3.5e-17	3.7e-17
7	TCGA	Breast Invasive Carcinoma	0.0257	0.0110	8.9e-04	0.020	0.012	0.014	NA	0.012	3.7e-05	1.1e-03	5.9e-04	NA	1.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.4	0.9	0.2	0.4	-0.9	-0.8	0.1	1.0	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	2.3	0.2	-0.4	-0.4	0.3	0.5	-0.1	-1.5
Depressed Affect (Nagel 2018)	0.4	0.9	2.2	1.5	0.4	0.6	-0.1	1.5	-0.3	-1.1
Depression (Nagel 2018)	0.2	0.3	0.9	0.3	0.5	-0.2	-0.7	-0.1	0.0	-0.9
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	0.7	-0.1	0.8	0.2	0.8	0.7	0.2
Neuroticism (Nagel 2018)	0.1	0.3	1.2	-0.0	0.6	0.1	-0.5	0.1	-0.1	-1.1
Schizophrenia (2018)	0.4	0.8	2.6	0.2	-0.9	0.2	1.1	0.5	-1.0	-1.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	1.3	-0.3	-0.1	0.4	0.0	0.6	0.9
Worry (Nagel 2018)	0.0	0.1	0.4	-0.1	-0.1	-0.0	0.1	-0.1	-0.0	-0.6
Alzheimer’s Disease (in mother)	1.8	2.2	7.1	0.2	-1.0	0.9	0.2	0.7	-2.4	-2.7
Alzheimer’s Disease (in father)	1.4	1.5	4.5	-1.3	0.5	2.1	0.8	-1.6	-1.0	-0.1
Alzheimer’s Disease (including proxy)	1.0	1.5	3.5	-0.6	0.2	1.7	-0.2	-0.6	-1.9	-1.7
Crohns Disease (2017)	0.3	0.6	2.1	-0.8	-0.6	-0.5	-0.6	-1.4	0.5	0.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	0.8	-0.5	-0.5	-0.6	0.1	1.3	-0.2
Ulcerative Colitis (UC)	0.3	0.5	1.4	1.1	0.4	-0.4	-0.3	0.7	1.2	-0.4
Major Depression (MDD)	1.5	1.8	4.9	0.4	1.5	-1.7	-2.2	0.5	0.5	-1.4
Reaction Time	1.1	2.1	6.5	-0.3	2.5	-1.8	-1.7	-0.0	1.3	0.5
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.8	0.5	-0.4	2.2	1.3	0.6	1.1	1.1
Breast Cancer	0.1	0.3	0.9	0.3	-0.6	-1.0	-0.3	0.6	0.5	0.1
Ovarian Cancer	1.1	1.5	6.0	0.3	-1.0	-0.7	-0.8	-0.2	-1.4	-2.5
Prostate Cancer	0.4	0.6	1.9	0.6	-0.1	-0.3	-0.5	0.7	-1.1	-1.4
Age at First Birth	0.3	0.5	1.6	0.3	0.5	0.1	-0.5	1.3	-1.1	-0.0
Bipolar Disorder (2011)	0.3	0.2	1.0	0.3	-0.5	-0.3	-0.1	1.0	0.3	-0.5
Body Mass Index (BMI) (2010)	0.9	1.3	2.8	1.2	-1.6	-0.3	-0.7	1.0	-1.7	-0.9
Coronary Artery Disease (CAD)	0.8	1.0	3.0	0.2	1.2	-1.7	-1.2	0.3	1.0	-0.3
Crohns Disease (2012)	0.5	0.8	2.0	-0.3	-1.3	-1.1	-1.4	-0.8	-0.3	-0.5
Mean Putamen Volume	1.0	1.2	4.5	1.2	1.2	0.0	-0.2	0.7	-0.5	-2.1
Fasting Glucose	0.2	0.2	0.9	0.3	0.4	-0.9	-0.2	0.4	-0.2	-0.4
HbA1C	0.4	0.4	1.0	0.1	1.0	-0.2	-0.7	-1.0	-0.1	0.7
HDL Cholesterol	0.3	0.6	1.5	-0.6	0.3	-0.1	0.8	-1.2	1.2	0.0
LDL Cholesterol	0.5	0.8	1.8	0.3	1.3	-0.7	-1.0	0.2	1.0	1.0
Lupus	0.3	0.5	1.3	0.9	-0.3	-0.1	-0.4	0.6	0.8	1.1
Neuroticism (2016)	0.3	0.4	1.3	-0.8	1.1	-0.1	0.0	-1.0	-0.1	-0.3
Primary Biliary Cirrhosis	1.7	2.4	4.9	-1.3	-1.6	1.3	0.9	-2.2	-1.5	-1.7
Rheumatoid Arthritis	0.6	0.9	2.5	-0.4	0.9	-1.2	-1.6	-0.8	-0.8	-0.0
Schizophrenia (2014)	0.2	0.4	0.9	0.4	-0.7	-0.5	0.9	0.4	-0.6	-1.0
Triglycerides	0.1	0.2	0.4	0.5	0.4	0.0	-0.6	0.5	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.3	0.3	-0.6	0.1	-0.7	0.7	-0.2	-1.5
Ulcerative Colitis	1.1	1.6	4.8	1.6	0.9	-0.6	-0.4	1.2	2.2	1.0
Blood Eosinophil Count	0.8	6.0	16.9	1.4	-4.1	2.7	3.2	1.6	-0.9	-1.3
Blood Platelet Count	1.0	11.4	28.6	-3.2	-3.0	-2.3	-1.9	-5.3	-4.8	-0.5
Blood Red Count	0.2	1.6	3.9	-0.4	-0.4	2.0	1.8	1.0	-0.3	1.5
Blood White Count	0.4	3.2	6.7	2.6	-1.4	0.9	2.0	2.6	-0.4	-1.4
Heel T-Score	0.2	1.4	7.6	0.6	0.4	-0.5	-0.7	1.0	2.8	0.0
BMI	0.9	5.4	16.5	1.4	-1.9	3.8	4.1	0.6	-1.1	-0.1
Height	0.3	6.7	15.4	-3.9	3.6	-2.0	-2.5	-2.2	1.6	-0.8
Waist Hip Ratio (WHR)	2.0	9.1	29.5	0.5	4.6	-0.7	-1.6	-0.1	5.4	3.1
Systolic Blood Pressure	1.5	7.3	22.2	-2.1	1.6	-4.7	-3.4	-1.0	2.7	1.6
Smoking Status	1.5	3.5	11.3	3.4	-0.3	2.0	1.1	2.3	-0.9	-1.4
Allergy or Eczema	0.1	0.4	1.3	-0.0	0.5	-0.8	-1.1	0.2	-0.7	-0.0
Cardiovascular Disease	0.6	2.1	5.3	-0.7	1.9	-2.3	-1.1	-1.3	1.3	-0.6
Hypothyroidism (self reported)	0.6	1.3	4.6	-0.4	0.4	2.1	1.2	-1.4	1.0	0.3
Respiratory disease	1.6	3.5	11.1	0.9	-3.3	1.1	0.9	1.2	-2.6	-1.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	0.4	0.2	-0.5	-0.9	-1.4	-0.8	-0.1
Lung FEV1/FVC ratio	0.5	2.4	6.4	2.5	2.0	-0.2	-1.1	0.2	-0.7	2.3
Lung FVC	1.7	8.4	20.3	3.3	-2.4	2.9	2.5	4.5	0.5	-2.6
Neuroticism	0.3	0.6	3.2	-0.0	-0.4	-0.2	-0.2	0.3	-1.0	-1.8
Chronotype (morning person)	0.4	0.8	3.2	-1.8	-0.0	-0.5	-0.5	-1.3	-0.3	-0.6
Hair Pigment	0.3	8.9	25.8	1.1	-2.8	1.4	0.8	1.8	-5.1	-4.6
Tanning	0.5	6.0	16.6	-2.4	-4.1	0.0	1.8	-2.5	2.5	2.0
Hand grip strength (left)	1.6	4.1	10.2	-3.2	-2.9	0.5	0.8	-2.0	-1.0	-2.1
Number of treatments/medications taken	0.8	1.5	3.2	1.5	1.4	-1.8	-1.5	0.4	0.3	0.4
Average weekly spirits intake	0.9	1.1	2.7	-0.3	-0.9	1.6	1.3	0.1	1.1	-1.1
Sensitivity / hurt feelings	0.7	1.2	2.1	-1.1	1.0	-1.0	-1.2	-1.1	0.1	-1.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.5	-0.1	1.9	-0.6	-1.2	-0.6	-0.5	0.4
Hearing difficulty/problems: Yes	0.5	0.7	1.6	0.8	-0.4	0.7	1.0	1.3	0.7	0.9
Relative age of first facial hair	0.8	1.7	3.7	1.6	-1.8	-0.7	0.4	1.3	-1.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	0.9	0.3	0.5	0.2	0.4	-0.5	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.5	0.4	-0.6	0.7	0.2	0.1	-1.6	-0.1
Ever had hysterectomy (womb removed)	1.3	1.4	3.1	1.4	-1.3	1.8	1.0	0.6	-1.2	-0.5
Systolic blood pressure, automated reading	1.4	4.1	9.4	-1.0	1.1	-2.9	-2.3	0.3	3.1	1.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.8	0.9	0.2	0.2	-0.6	-0.3	0.3
Angina	0.4	0.5	1.3	0.6	-0.2	-0.8	-0.6	1.2	0.8	0.3
Medication for hormone replacement therapy	0.7	0.7	2.7	1.6	0.5	-0.9	-0.6	0.8	0.4	0.7
Vitamin and mineral supplements	0.5	0.7	2.0	-0.5	0.6	1.1	1.4	-0.2	0.9	0.2
Supplements: Zinc	1.7	1.8	3.8	1.3	-0.7	-1.0	-1.9	1.8	1.1	1.2
Medication: Co-codamol	0.8	0.9	3.3	-0.7	1.0	-0.6	-0.7	-1.8	-0.1	0.8
Medication: Metformin	0.6	0.9	2.8	-1.1	0.0	-0.7	-0.8	-1.7	-1.1	-0.2
Diabetes (father)	0.1	0.2	0.4	0.0	0.6	0.5	-0.2	0.4	-0.4	-0.5
Diabetes (mother)	1.6	2.1	6.0	-1.0	-1.2	1.5	2.4	-1.4	-0.5	-1.3
Severe depression (siblings)	0.6	0.7	1.2	1.1	-0.8	0.6	0.6	0.6	-1.1	-1.0
Pack years adult smoking proportion	0.1	0.2	0.4	0.1	-0.5	-0.3	-0.4	0.5	-0.7	-0.5
Impedance of leg (right)	0.6	2.8	10.0	-0.9	2.6	-0.2	-0.1	0.0	3.2	1.4
Leg fat-free mass (left)	0.3	1.4	2.2	-0.5	-0.6	1.5	1.4	-1.2	-1.4	-1.2
Trunk fat percentage	0.8	3.1	8.5	-0.0	2.6	0.7	0.7	-0.2	2.9	2.4
Hand grip strength (right)	1.1	3.0	7.1	-2.7	-2.5	0.5	0.5	-1.6	-1.1	-1.9
Townsend deprivation index at recruitment	0.8	1.1	2.5	0.3	-0.5	1.2	1.6	-0.5	-1.5	-1.0
Current tobacco smoking	1.2	2.0	3.6	1.9	-0.8	1.5	1.7	0.8	-1.8	-0.8
Average weekly fortified wine intake	2.1	2.4	6.6	1.2	-2.3	1.4	0.8	2.6	0.2	-0.9
Maternal smoking around birth	0.7	1.1	5.5	0.5	-0.4	0.7	0.9	-0.4	-2.3	-0.1
Fed-up feelings	0.6	1.0	2.6	1.0	1.5	0.3	0.1	0.9	-0.7	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	7.1	0.6	-0.7	0.0	-0.5	-0.5	-2.7	-1.4
Relative age voice broke	0.4	0.6	2.3	0.8	-0.5	0.2	0.1	0.9	-1.5	-0.3
Taking other prescription medications	1.5	2.2	7.1	2.6	0.3	1.0	0.7	2.7	-0.2	-0.6
Age when periods started (menarche)	1.1	2.5	6.2	1.5	1.6	-0.5	-0.1	0.8	2.5	2.5
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	9.5	0.0	-3.1	1.8	1.5	0.8	-2.5	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.0	-0.9	-1.4	1.1	1.1	0.2	-0.2	-0.7
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.2	0.7	1.1	1.6	1.3	0.4	1.7	1.8
Qualifications: CSEs or equivalent	0.3	0.3	1.2	-0.9	-0.4	0.1	0.3	-1.1	0.1	-0.2
Serious illness, injury or assault to yourself	1.1	1.4	5.6	0.3	0.6	1.5	0.8	-0.3	2.4	-0.8
High blood pressure	1.5	4.2	14.5	-1.4	2.2	-3.8	-1.8	-1.7	1.5	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.4	0.1	0.1	-0.4	-1.3	0.3	-1.9	-0.7
Multivitamins +/- minerals	1.5	2.0	4.9	1.3	-0.3	-1.8	-2.2	1.1	-1.6	-0.3
Stomach or abdominal pain in last month	0.6	0.8	2.3	1.5	0.4	0.4	-0.2	1.4	0.3	0.7
Supplements: Glucosamine	0.1	0.1	0.2	0.5	-0.0	-0.2	-0.4	-0.2	-0.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	0.1	0.2	1.0	0.6	-0.4	0.5	0.5
Medication: Atenolol	2.2	2.7	11.2	-0.0	1.3	-3.4	-1.6	0.4	0.5	-1.8
Medication: Levothyroxine sodium	1.5	2.6	7.7	-1.0	1.0	2.8	1.7	-2.2	0.4	0.7
Sitting height	0.1	1.0	5.6	0.3	-0.5	-0.0	0.0	0.2	-1.0	-2.4
Chronic bronchitis/emphysema (father)	1.0	1.2	3.3	1.6	-0.4	0.7	0.8	1.8	0.4	-1.1
High blood pressure (mother)	1.3	1.8	4.9	-1.8	-0.3	-1.2	-0.9	-2.2	-1.3	-0.7
Body mass index (BMI)	0.4	1.8	5.5	1.3	-0.4	2.3	2.2	0.7	-0.4	0.3
Impedance of leg (left)	0.7	3.3	9.9	-1.2	2.9	-0.6	-0.6	-0.3	3.1	1.7
Leg predicted mass (left)	0.3	1.4	2.2	-0.5	-0.7	1.5	1.3	-1.2	-1.5	-1.2
Trunk fat mass	0.5	2.1	4.0	-0.2	2.0	1.5	1.4	-0.4	2.0	1.5
Waist circumference	0.5	2.0	4.3	0.9	1.7	2.1	1.6	0.5	1.5	0.8
Number of incorrect matches in round	1.4	2.3	6.9	0.7	0.8	-2.6	-2.6	0.0	-1.1	0.1
Past tobacco smoking	1.1	2.0	5.9	-2.4	-0.6	-1.2	-1.0	-1.8	-0.8	1.3
Alcohol usually taken with meals	1.2	1.9	4.2	0.8	1.2	-1.3	-1.4	1.8	2.0	0.3
Nervous feelings	0.2	0.5	1.2	-0.7	0.5	0.3	0.1	-0.8	-1.1	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	5.3	-0.6	1.1	-0.6	-0.8	-0.9	-0.5	-2.3
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.4	-0.5	-0.0	0.2	0.1	0.6	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	0.7	1.3	0.2	-0.2	-0.0	-0.8	0.7
Had menopause	0.4	0.6	1.2	0.1	-0.9	0.5	-0.4	0.6	1.0	1.1
Had other major operations	0.5	0.6	1.2	-0.1	-1.0	1.0	0.6	-1.1	-0.5	-0.7
Forced vital capacity (FVC)	0.9	3.3	8.0	1.1	-1.1	2.8	2.6	1.5	0.1	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.5	-0.2	-0.2	0.1	0.0	1.2	-0.0	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	0.2	1.2	0.2	-0.8	1.0	0.6	-0.3
Qualifications: None of the above	0.1	0.2	0.6	0.5	0.0	-0.5	-0.8	-0.2	-0.4	-0.2
Financial difficulties in last 2 years	1.5	2.0	9.5	1.2	-1.1	-0.4	-0.3	0.2	-3.1	-1.2
Mouth/teeth dental problems	0.4	0.6	1.5	0.2	-1.1	-0.1	0.6	0.6	-1.2	-0.9
Heart attack	1.9	2.5	5.9	1.8	1.1	-2.4	-1.8	0.8	1.6	-0.8
Allergy	0.6	1.3	5.4	-0.5	1.2	-0.2	0.4	-0.9	2.3	0.9
Pain all over the body in last month	0.2	0.2	1.0	-0.3	-1.0	0.0	0.4	-0.5	-0.1	-0.0
Diabetes (self-reported)	0.6	1.0	2.8	-0.4	-0.2	-0.7	-1.3	-1.7	-1.3	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.3	0.2	-1.0	-0.7	0.6	0.4	0.2
Medication: Ramipril	0.8	1.1	1.9	1.0	1.4	-1.1	-1.4	0.1	0.8	0.9
Medication: Simvastatin	0.4	0.6	2.1	-0.1	0.1	0.7	0.9	-1.4	-0.0	0.9
Fluid intelligence score	0.5	1.1	3.2	1.1	-1.8	1.1	0.9	1.0	0.1	-0.3
Illnesses of siblings	1.6	2.3	4.4	1.4	1.7	1.5	1.8	0.5	0.9	2.1
Neuroticism score	0.4	0.8	3.5	0.2	0.6	0.2	0.3	0.1	-1.2	-1.9
Weight	0.3	1.3	5.0	-0.0	0.5	2.2	1.9	-0.5	0.1	-0.1
Impedance of arm (right)	2.7	12.4	23.6	-2.5	4.5	-3.4	-3.6	-1.6	4.9	3.0
Arm fat percentage (right)	0.4	1.6	3.9	-0.2	1.7	1.0	0.8	-0.5	2.0	1.8
Trunk fat-free mass	0.6	3.4	5.1	-1.1	-1.2	2.3	2.0	-1.7	-2.1	-2.2
Hip circumference	0.3	1.1	3.6	0.4	0.3	1.9	1.8	-0.1	-0.9	0.3
Time employed in main current job	0.8	0.9	3.0	-1.3	0.9	0.8	0.5	-1.7	0.2	-0.0
Alcohol intake versus 10 years previously	0.4	0.6	1.4	0.9	0.2	0.8	0.7	0.5	-0.8	-1.2
Father’s age at death	0.4	0.5	1.0	0.1	0.6	1.0	0.5	0.3	0.9	1.0
Worrier / anxious feelings	0.5	1.0	2.6	-0.0	-0.2	1.6	1.4	-0.1	-0.3	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	0.7	0.9	0.3	-0.9	0.8	-0.7	-0.8
Falls in the last year	1.1	1.5	3.0	1.7	1.1	-1.5	-1.6	0.8	-0.6	-0.4
Hair/balding pattern: Pattern 3	0.7	1.0	3.6	-0.4	-0.1	-1.4	-1.9	0.3	-0.6	-1.0
Number of live births	1.8	2.5	6.5	1.1	-2.5	-0.6	-0.4	1.5	-2.1	-1.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.2	1.6	-0.4	1.8	1.5	1.4	-0.4	-1.1
Pulse rate	1.5	2.5	6.1	0.5	1.4	1.5	1.7	-0.3	2.5	2.0
Happiness	1.0	1.2	2.5	-0.6	1.6	-1.5	-1.5	-0.9	-0.1	-0.6
Noisy workplace	1.0	1.2	2.8	0.7	0.0	1.0	0.6	1.7	-1.2	-1.6
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.1	-0.3	-0.7	1.1	1.8	-0.7	0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.1	-0.4	1.3	1.3	1.4	0.2	0.2	1.5
Mouth/teeth dental problems: Dentures	0.9	1.5	5.3	-1.4	-1.5	0.6	0.5	-2.3	0.6	0.3
Asthma	2.3	4.6	14.7	0.3	-3.8	0.7	0.9	1.0	-2.6	-2.9
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.6	0.4	1.9	-1.5	-1.1	-0.5	1.2	-0.3
Medication: Cholesterol lowering	0.2	0.4	1.6	0.7	1.3	-0.5	-0.0	0.0	0.3	0.4
Depression (self-reported)	1.0	1.2	3.7	1.9	-0.2	-0.3	-1.1	1.1	-1.6	-0.3
Medication: Lansoprazole	0.5	0.6	1.7	1.3	0.4	0.2	-0.3	1.3	0.1	-0.7
Prospective memory result	0.3	0.4	1.1	0.3	0.2	0.7	0.7	0.3	0.7	-1.1
Lung cancer (father)	0.7	0.8	2.9	0.4	0.5	-0.7	-1.7	0.1	-1.3	0.3
Illnesses of mother	2.0	2.4	6.3	2.5	0.3	1.5	1.3	2.4	0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.8	1.7	0.1	1.3	0.9	1.0	-0.2	-0.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	-0.2	1.0	0.4	0.9	-0.7	1.0	-0.5
Impedance of arm (left)	2.3	10.7	21.3	-1.8	4.3	-3.5	-3.3	-0.9	4.6	2.7
Arm fat mass (right)	0.3	1.1	3.1	-0.1	1.0	1.8	1.4	-0.6	0.8	0.7
Trunk predicted mass	0.6	3.5	5.8	-1.0	-1.3	2.4	2.2	-1.6	-2.0	-2.1
Standing height	0.3	3.2	8.9	-3.0	2.2	-0.1	-0.4	-2.6	1.0	-0.8
Length of working week for main job	0.4	0.5	3.1	-0.1	-1.7	-0.3	0.0	-0.3	-0.3	-0.3
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.2	0.3	0.3	0.9	-0.9	-0.6	0.4
Breastfed as a baby	0.6	0.7	2.0	0.8	-1.3	-0.5	-0.1	0.5	-1.4	-0.4
Tense / ‘highly strung’	0.5	0.8	2.4	-0.7	1.5	-0.5	-0.7	-0.1	-0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	5.1	0.7	1.5	2.3	1.3	1.0	0.6	-0.8
Hair/balding pattern: Pattern 4	0.1	0.4	1.0	0.6	0.5	0.2	0.2	-0.2	1.0	0.9
Birth weight of first child	2.0	3.6	7.3	1.2	-2.7	1.4	0.9	2.2	-2.6	-1.5
Peak expiratory flow (PEF)	0.6	1.4	3.2	1.2	0.5	1.2	1.4	1.1	-1.8	-0.7
Pulse wave reflection index	0.5	0.6	3.1	0.1	-0.8	-0.3	0.2	0.1	-0.7	-1.8
Ever highly irritable/argumentative for 2 days	1.2	1.5	5.1	0.2	-0.1	2.3	1.7	0.2	-1.2	-0.9
Loud music exposure frequency	0.5	0.6	1.5	-0.9	-0.7	0.2	-0.2	-1.2	-0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	0.1	-0.1	0.9	1.0	-1.0	-0.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.8	0.3	1.0	-0.5	-1.3	-0.0	0.3	0.3
Blood clot in the leg (DVT)	0.4	0.6	1.7	1.3	-0.1	-0.3	-0.7	1.2	-0.4	0.3
Medication: Paracetamol	0.3	0.5	1.3	1.1	0.3	-0.9	-0.4	1.2	-0.3	-0.1
Headache pain in last month	0.8	1.3	3.5	0.7	1.2	-1.9	-1.5	0.6	1.1	0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	-0.2	-1.4	0.6	-0.0	0.1	-1.4	-0.4
Glaucoma (self-reported)	0.6	0.7	2.2	0.7	0.6	1.5	1.0	-1.0	-0.3	0.2
Gout (self-reported)	0.9	1.3	3.0	-0.4	-1.3	1.5	1.7	-1.0	-0.8	0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.4	-0.8	1.0	2.1	0.8	-1.9	1.1	0.8
Medication: Amlodipine	0.5	0.8	2.3	-1.5	0.3	-1.1	-0.2	-1.1	-0.7	-0.4
Medication: Ventolin 100micrograms inhaler	1.6	2.0	5.5	-0.2	-1.9	2.3	2.2	-0.3	-0.3	-0.2
Birth weight	1.3	2.9	8.6	0.5	-0.2	2.8	2.9	1.6	0.3	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.0	-0.4	0.0	-0.6	-0.1	-1.3	0.4	1.4
High blood pressure (siblings)	1.8	2.5	5.4	-1.1	-2.0	-1.3	-1.3	-0.4	-1.9	-2.3
Forced vital capacity (FVC), Best measure	0.6	2.0	5.6	1.1	-0.8	2.4	2.2	0.9	-0.0	-1.0
Body fat percentage	0.6	2.3	5.2	0.1	1.8	1.6	1.5	0.0	2.3	1.8
Leg fat percentage (right)	1.0	3.6	9.6	1.1	0.5	3.1	3.0	1.0	1.7	1.3
Arm fat-free mass (right)	0.7	3.7	7.0	-0.2	-1.6	2.6	2.6	-0.7	-2.1	-2.2
Exposure to tobacco smoke outside home	0.9	1.2	2.7	-1.6	-0.2	-1.3	-1.0	-1.1	0.5	1.3
Comparative body size at age 10	1.5	4.2	8.9	3.0	-2.4	1.7	2.4	2.4	-0.1	0.4
Number of full brothers	0.9	1.1	2.7	-1.4	-1.0	-1.6	-0.4	-0.0	-1.2	-0.5
Worry too long after embarrassment	0.8	1.3	3.1	-1.8	1.3	1.2	0.7	-0.6	-0.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	1.5	0.3	0.9	0.9	1.5	0.2	-1.2
Wheeze or whistling in the chest in last year	2.0	3.5	8.2	0.8	-2.9	1.1	0.9	1.4	-2.8	-2.0
Number of children fathered	0.2	0.2	0.3	0.4	0.5	-0.3	-0.4	0.5	-0.0	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.7	0.8	-0.5	1.4	1.5	0.2	2.2	0.3
Age at first live birth	0.9	1.7	5.8	-2.4	-0.1	0.2	1.1	-2.2	-0.1	0.1
Pulse wave peak to peak time	0.4	0.5	1.4	-0.0	-1.2	-0.3	-0.8	0.5	-0.9	0.3
Health satisfaction	1.2	1.6	4.5	1.0	0.9	-2.1	-2.0	0.3	0.4	-0.6
Shortness of breath walking on level ground	0.5	0.6	0.9	0.6	0.9	0.8	0.8	0.0	-0.9	-0.9
Qualifications: College or University degree	0.2	0.7	1.9	-0.2	-0.2	0.5	1.4	0.8	0.4	1.2
Eye problems/disorders: None of the above	1.5	1.7	6.4	1.9	-2.5	-0.2	0.1	1.2	-0.7	-0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	5.7	-1.1	0.6	-0.1	-0.2	-0.5	1.1	2.4
Emphysema/chronic bronchitis	0.9	1.1	3.1	1.0	0.6	-0.4	-0.0	1.7	-0.2	-1.8
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-0.9	-1.3	1.2	1.1	-0.6	-0.8	0.3
Neck or shoulder pain in last month	0.3	0.5	1.4	-1.2	0.5	0.4	0.3	-0.5	0.8	-0.8
Medication: Blood pressure	0.9	1.7	3.8	0.5	1.5	-1.7	-0.9	0.6	2.0	1.0
Angina (self-reported)	0.7	0.9	2.0	0.6	0.1	-1.4	-1.3	1.2	0.8	0.4
Migraine (self-reported)	0.7	0.9	1.8	-0.2	1.1	0.5	1.3	0.9	1.3	0.7
Medication: Ibuprofen	0.7	0.9	2.4	0.2	1.1	-1.6	-1.0	-0.8	0.7	-0.2
Medication: Allopurinol	0.6	0.8	1.4	-0.7	-1.0	0.2	0.8	-1.2	-0.8	1.1
Medication: Omeprazole	0.9	1.1	2.1	1.4	0.2	0.2	-0.5	1.5	1.4	1.2
Medication: Seretide 50 evohaler	0.5	0.6	1.7	1.3	-0.9	0.7	0.9	0.5	0.0	0.5
Mean time to correctly identify matches	1.5	2.8	5.7	-0.7	2.3	-2.3	-2.4	-0.0	1.5	0.8
Heart disease (mother)	1.7	2.0	4.7	-1.5	-1.4	-1.3	-1.5	-1.1	-2.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.1	-0.6	0.6	-1.7	-1.2	-0.8	-1.4	-1.2
Whole body fat mass	0.4	1.6	3.8	-0.2	1.3	2.0	1.8	-0.5	1.1	1.0
Leg fat mass (right)	0.6	2.2	7.8	0.3	0.2	2.8	2.7	-0.0	0.4	0.5
Arm predicted mass (right)	0.7	3.6	6.7	0.1	-1.7	2.6	2.5	-0.7	-2.0	-2.3
Pulse rate, automated reading	1.1	3.5	13.9	-0.4	0.2	1.8	2.5	-0.0	3.7	1.1
Alcohol intake frequency.	0.1	0.3	0.9	0.4	0.1	-0.5	-0.9	0.2	-0.7	0.4
Comparative height size at age 10	0.5	2.8	6.3	-2.5	1.8	-0.5	-1.5	-1.8	2.2	-0.4
Number of full sisters	0.7	0.8	1.9	-0.1	-1.4	0.5	0.1	0.5	-1.3	-1.2
Suffer from ‘nerves’	0.2	0.3	1.3	-0.3	1.1	-0.3	-0.7	-0.2	0.0	-0.1
Overall health rating	0.3	0.7	2.9	1.7	0.4	-0.6	-0.3	0.5	0.0	-1.0
Chest pain or discomfort	1.1	1.6	4.2	-1.1	-1.0	2.0	1.7	-0.4	-1.2	-0.2
Had major operations	0.8	1.0	3.8	0.1	0.7	1.2	0.9	0.1	2.0	-0.4
Age at last live birth	1.1	1.7	4.3	-2.1	-0.5	0.3	1.8	-1.9	-0.3	0.4
Family relationship satisfaction	0.2	0.2	0.5	-0.7	0.4	-0.2	-0.3	-0.7	-0.2	-0.6
Leg pain on walking	0.5	0.7	2.1	-0.0	-0.6	-0.0	0.0	-0.5	-1.4	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	5.2	0.8	-0.6	-2.3	-1.5	1.3	0.4	-1.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.2	-1.2	1.1	1.1	0.4	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.9	-0.4	0.1	0.2	0.5	-0.5	1.8	2.0
Medication: Aspirin	0.1	0.2	0.3	-0.3	0.5	-0.3	-0.5	-0.5	-0.3	-0.6
Supplements: Vitamin C	0.0	0.1	0.1	0.3	-0.1	0.2	-0.3	0.2	-0.3	0.2
Knee pain experienced in last month	0.3	0.5	1.2	-0.2	-0.6	0.2	-0.1	-0.7	-1.1	-1.0
Hypertension (Self-reported)	1.9	5.3	17.1	-1.8	2.3	-4.1	-2.0	-2.1	1.8	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.9	1.4	2.0	-0.7	-1.8	1.4	1.3	-0.2
Illnesses of father: Heart disease	0.7	1.0	3.1	-0.7	-0.5	-1.1	-1.8	0.5	-0.7	-1.0
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-0.1	-1.0	0.5	-0.2	0.1	-0.9	-1.2
Smoking status: Previous	1.2	1.8	4.4	1.8	1.3	0.7	0.1	2.1	1.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.5	-0.7	0.9	0.6	0.3	-1.9	-1.4	-0.6
Whole body fat-free mass	0.5	2.7	4.1	-0.8	-1.1	2.0	1.8	-1.5	-2.0	-1.9
Leg fat-free mass (right)	0.3	1.4	3.0	-0.6	-0.6	1.1	0.9	-1.5	-1.7	-1.3
Arm fat percentage (left)	0.4	1.5	3.5	-0.0	1.5	1.1	1.1	-0.2	1.9	1.5
Average weekly red wine intake	1.9	2.8	7.0	0.2	0.4	-2.6	-2.6	0.9	1.8	-1.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	5.0	-1.1	-0.8	0.7	1.1	-2.2	-0.8	-0.2
Mood swings	0.3	0.6	2.1	0.1	1.5	0.1	0.3	-0.7	-1.1	-0.3
Loneliness, isolation	0.4	0.6	1.3	-0.8	0.7	-0.0	0.9	-0.7	-1.1	-0.7
Long-standing illness, disability or infirmity	0.6	0.8	2.9	1.2	-0.1	0.8	0.4	0.2	-0.7	-1.7
Ever had bowel cancer screening	0.3	0.4	0.9	0.6	1.0	0.2	-0.7	-0.6	-0.7	0.1
Diabetes diagnosed by doctor	0.3	0.5	2.1	-0.1	0.0	-0.3	-0.8	-0.7	-1.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.6	0.0	-0.3	-0.8	0.1	-1.0	-1.3	-0.7
Friendships satisfaction	0.5	0.6	1.0	-0.9	0.1	1.0	0.8	-0.8	-0.5	-0.8
Qualifications: nursing, teaching	0.9	1.4	2.9	-1.2	0.7	0.8	1.7	-0.9	1.3	1.1
Commuting to job workplace: Walk	1.1	1.2	3.2	-1.6	0.7	-0.1	0.0	-1.2	1.8	0.6
Eye problems/disorders: Cataract	0.3	0.4	1.3	-0.2	1.1	0.1	0.3	0.6	-0.3	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	6.4	0.3	2.5	0.5	0.7	0.3	0.8	0.7
Medication for cholesterol	1.5	2.3	5.4	1.3	-1.5	2.3	1.4	2.2	0.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	-0.1	-0.1	-0.9	-0.4	0.3	-0.8	-1.0
Back pain experienced in last month	0.7	1.1	3.1	1.0	-1.0	-0.2	-0.3	-0.0	-1.8	-1.5
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	-0.1	-0.4	0.3	0.0	-0.2	0.1
Breast cancer (self-reported)	0.3	0.4	1.3	0.2	-0.4	0.4	-0.2	-0.7	-0.5	-1.1
Asthma (self-reported)	2.3	4.6	15.8	0.3	-4.0	0.8	1.0	0.9	-2.6	-2.6
Osteoporosis (self-reported)	2.3	2.8	7.6	1.2	2.8	-1.6	-1.4	0.9	1.9	1.4
Osteoarthritis (self-reported)	0.6	0.7	2.1	1.0	-1.4	0.4	-0.1	0.6	-0.9	-0.9
Medication: Aspirin	0.2	0.3	0.7	-0.6	0.8	-0.3	-0.4	-0.7	0.2	-0.2
Medication: Gliclazide	1.3	1.5	3.1	-1.1	-0.1	1.4	0.8	-1.7	-1.8	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.4	1.9	-0.1	-0.4	-0.3	0.1	-0.9	-0.1	1.4
Smoking status: Current	1.2	1.9	3.9	1.8	-1.1	1.4	1.6	0.4	-2.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.1	2.3	-1.0	1.7	1.2	1.9	1.0	1.5
Whole body water mass	0.5	2.9	4.3	-0.8	-1.1	2.1	1.9	-1.5	-2.0	-2.0
Leg predicted mass (right)	0.3	1.5	3.0	-0.7	-0.6	1.1	0.9	-1.6	-1.7	-1.3
Arm fat mass (left)	0.3	1.4	3.5	-0.2	1.0	1.9	1.7	-0.6	0.9	0.9
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	1.2	1.0	0.2	0.2	1.0	0.6	-0.2
Average weekly champagne plus white wine intake	0.7	1.0	3.6	-0.6	-0.6	1.4	1.9	-0.5	0.4	-0.5
Miserableness	0.9	1.5	4.1	2.0	0.1	-0.2	-1.0	1.3	-0.9	-1.7
Guilty feelings	0.6	0.9	3.6	0.2	-0.3	0.7	1.1	0.2	-0.8	-1.9
Wears glasses or contact lenses	1.4	1.6	3.3	0.3	-0.8	1.7	1.8	1.5	1.5	0.1
Ever taken oral contraceptive pill	1.7	1.8	6.8	0.7	-0.1	0.7	0.6	1.4	-1.7	-2.6
Hearing aid user	2.0	2.2	5.5	-2.4	0.7	1.3	1.2	-1.5	2.0	0.5
Mother’s age at death	0.3	0.4	1.1	-0.3	-0.7	0.3	0.9	1.0	0.2	-0.6
Financial situation satisfaction	0.6	0.7	1.6	-0.8	0.6	-1.3	-0.8	-1.1	-0.6	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	0.3	0.9	-0.4	-1.1	0.1	-0.0	0.2
Commuting to job workplace: Public transport	0.4	0.4	0.8	0.7	0.7	-0.8	-0.1	-0.8	0.3	0.9
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	-0.6	0.6	1.2	0.6	-0.8	-0.1	0.6
Medication: Blood pressure	2.4	4.5	12.0	-1.9	1.3	-3.5	-2.0	-3.1	-0.4	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	0.2	0.2	0.2	-0.1	-0.0	-0.8	-1.0
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.8	0.0	0.1	-0.1	-0.9	-0.4	-0.0	0.2
High cholesterol (Self-reported)	0.7	1.2	2.8	1.7	1.6	0.4	0.4	0.7	1.2	1.1
Medication: Bendroflumethiazide	1.3	2.0	6.6	0.1	0.4	-2.6	-1.7	-0.5	-0.6	-1.9
Medication: Paracetamol	0.6	1.0	2.6	1.3	0.4	-1.4	-0.8	1.6	-0.1	-0.1
Medication: Lisinopril	0.9	1.1	4.2	0.2	0.0	-0.9	-1.0	-0.6	-1.2	-2.0
Medication: Atorvastatin	0.2	0.3	1.4	-0.4	-0.1	-0.5	-0.1	-0.4	-0.3	-1.2
Illnesses of father: High blood pressure	0.4	0.4	1.3	-1.0	-0.6	-0.3	0.4	0.2	0.1	-1.2
Alcohol drinker status: Never	0.3	0.4	1.2	-0.7	-0.8	-0.2	-0.3	0.1	1.1	0.4
Ever smoked	1.2	2.2	6.4	2.5	-0.1	1.4	1.4	1.5	-0.1	-1.6
Basal metabolic rate	0.4	2.3	4.8	-0.7	-0.6	2.2	2.0	-1.4	-1.6	-1.5
Leg fat percentage (left)	0.8	2.9	8.0	1.0	0.4	2.8	2.6	0.9	1.4	1.4
Arm fat-free mass (left)	0.7	3.3	7.9	-0.3	-1.3	2.8	2.4	-1.2	-1.8	-1.7
Number of operations (self-reported)	0.4	0.6	1.7	0.3	0.3	1.3	0.6	0.3	0.8	-1.1
Average weekly beer plus cider intake	0.7	1.0	2.5	1.0	-1.4	0.8	0.3	1.0	-1.6	-0.2
Irritability	0.5	0.9	2.6	-0.1	1.6	-1.4	-1.1	-0.5	0.3	0.3
Risk taking	0.7	1.0	2.4	0.3	-0.9	-1.3	-1.3	-0.0	-1.5	-0.7
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.3	0.7	0.4	1.8	1.2	1.0	-0.6	-0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.6	-0.3	-0.8	-0.2	0.1	0.1	0.0	0.7
Age started oral contraceptive pill	1.7	2.2	4.9	-1.7	0.3	1.6	1.3	-1.2	2.2	1.1
Diastolic blood pressure, automated reading	2.8	8.7	16.7	-0.4	2.6	-4.1	-3.4	1.0	3.7	3.2
Ever depressed for a whole week	0.4	0.5	1.1	-0.2	0.1	-0.3	-1.0	1.1	-0.4	-1.0
Unable to work because of sickness or disability	0.8	1.0	3.8	0.4	-0.2	-0.3	-1.2	0.1	-2.0	-1.1
Commuting to job workplace: Cycle	1.3	1.6	5.8	0.4	2.4	1.4	0.9	-0.7	1.1	0.9
Myopia	1.0	1.5	2.2	1.2	1.5	0.8	1.1	1.2	1.5	1.1
Vascular/heart problems diagnosed by doctor	1.4	3.8	11.2	1.3	-2.2	3.3	1.6	1.9	-1.5	0.4
Cholesterol lowering medication	0.1	0.2	0.3	0.5	-0.5	-0.4	-0.4	-0.2	-0.1	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.1	1.4	0.9	0.2	-0.4	1.2	2.3	1.3
Pain experienced in last month	0.3	0.5	1.3	0.5	-1.1	0.9	0.6	0.6	-0.6	0.2
Supplements: Calcium	1.2	1.3	3.7	1.6	0.7	-1.0	-1.1	1.9	0.4	0.1
Basal cell carcinoma (self-reported)	1.2	1.4	3.3	1.6	1.2	-1.0	-1.8	1.1	0.0	0.1
Heart attack/myocardial infarction (self-reported)	1.9	2.4	5.1	1.7	1.4	-2.2	-1.7	0.8	1.8	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	1.4	0.0	-0.6	-1.0	1.2	-0.3	0.7
Heart disease (siblings)	0.7	0.9	2.2	-0.7	-1.2	-1.3	-1.5	-0.1	0.2	-0.6
Alcohol drinker status: Previous	0.4	0.4	1.3	0.9	-0.1	1.1	0.4	0.9	-0.1	0.1
Pack years of smoking	0.1	0.1	0.4	-0.2	-0.6	-0.2	-0.4	0.6	-0.1	-0.3
Impedance of whole body	1.4	7.2	16.6	-1.6	3.8	-2.5	-2.4	-0.7	4.1	2.1
Leg fat mass (left)	0.5	2.0	7.5	0.3	0.2	2.7	2.5	-0.1	0.3	0.6
Arm predicted mass (left)	0.7	3.6	7.1	-0.2	-1.5	2.7	2.3	-1.0	-2.2	-2.1