TWAS hub - CDC42EP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0290	7.4e-03	0.051	0.009	0.035	0.039	0.043	6.6e-07	2.7e-02	3.9e-05	1.3e-05	5.5e-06
2	GTEx	Cells EBV-transformed lymphocytes	0.3690	0.1160	1.1e-03	-0.007	NA	0.017	NA	0.072	6.7e-01	NA	9.2e-02	NA	2.4e-03
3	GTEx	Cells Transformed fibroblasts	0.1110	0.0450	5.3e-03	0.022	NA	0.011	NA	0.028	8.5e-03	NA	4.7e-02	NA	3.5e-03
4	GTEx	Whole Blood	0.1010	0.0370	2.0e-03	0.010	NA	-0.002	NA	0.000	3.5e-02	NA	5.6e-01	NA	3.4e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0739	0.0299	7.0e-03	0.012	0.017	0.038	0.033	0.031	9.2e-03	2.5e-03	1.1e-05	3.5e-05	6.1e-05
6	YFS	Blood	0.0614	0.0146	2.0e-08	0.055	0.038	0.055	0.054	0.054	1.8e-17	2.1e-12	2.4e-17	3.5e-17	3.7e-17
7	TCGA	Breast Invasive Carcinoma	0.0257	0.0110	8.9e-04	0.020	0.012	0.014	NA	0.012	3.7e-05	1.1e-03	5.9e-04	NA	1.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	9.5	0.0	-3.1	1.8	1.5	0.8	-2.5	-2.5
Diastolic blood pressure, automated reading	2.8	8.7	16.7	-0.4	2.6	-4.1	-3.4	1.0	3.7	3.2
Impedance of arm (right)	2.7	12.4	23.6	-2.5	4.5	-3.4	-3.6	-1.6	4.9	3.0
Medication: Blood pressure	2.4	4.5	12.0	-1.9	1.3	-3.5	-2.0	-3.1	-0.4	-0.8
Asthma	2.3	4.6	14.7	0.3	-3.8	0.7	0.9	1.0	-2.6	-2.9
Impedance of arm (left)	2.3	10.7	21.3	-1.8	4.3	-3.5	-3.3	-0.9	4.6	2.7
Asthma (self-reported)	2.3	4.6	15.8	0.3	-4.0	0.8	1.0	0.9	-2.6	-2.6
Osteoporosis (self-reported)	2.3	2.8	7.6	1.2	2.8	-1.6	-1.4	0.9	1.9	1.4
Medication: Atenolol	2.2	2.7	11.2	-0.0	1.3	-3.4	-1.6	0.4	0.5	-1.8
Average weekly fortified wine intake	2.1	2.4	6.6	1.2	-2.3	1.4	0.8	2.6	0.2	-0.9
Waist Hip Ratio (WHR)	2.0	9.1	29.5	0.5	4.6	-0.7	-1.6	-0.1	5.4	3.1
Illnesses of mother	2.0	2.4	6.3	2.5	0.3	1.5	1.3	2.4	0.4	0.8
Birth weight of first child	2.0	3.6	7.3	1.2	-2.7	1.4	0.9	2.2	-2.6	-1.5
Wheeze or whistling in the chest in last year	2.0	3.5	8.2	0.8	-2.9	1.1	0.9	1.4	-2.8	-2.0
Hearing aid user	2.0	2.2	5.5	-2.4	0.7	1.3	1.2	-1.5	2.0	0.5
Heart attack	1.9	2.5	5.9	1.8	1.1	-2.4	-1.8	0.8	1.6	-0.8
Hypertension (Self-reported)	1.9	5.3	17.1	-1.8	2.3	-4.1	-2.0	-2.1	1.8	-0.1
Average weekly red wine intake	1.9	2.8	7.0	0.2	0.4	-2.6	-2.6	0.9	1.8	-1.4
Heart attack/myocardial infarction (self-reported)	1.9	2.4	5.1	1.7	1.4	-2.2	-1.7	0.8	1.8	-0.8
Alzheimer’s Disease (in mother)	1.8	2.2	7.1	0.2	-1.0	0.9	0.2	0.7	-2.4	-2.7
Number of live births	1.8	2.5	6.5	1.1	-2.5	-0.6	-0.4	1.5	-2.1	-1.7
High blood pressure (siblings)	1.8	2.5	5.4	-1.1	-2.0	-1.3	-1.3	-0.4	-1.9	-2.3
Primary Biliary Cirrhosis	1.7	2.4	4.9	-1.3	-1.6	1.3	0.9	-2.2	-1.5	-1.7
Lung FVC	1.7	8.4	20.3	3.3	-2.4	2.9	2.5	4.5	0.5	-2.6
Supplements: Zinc	1.7	1.8	3.8	1.3	-0.7	-1.0	-1.9	1.8	1.1	1.2
Heart disease (mother)	1.7	2.0	4.7	-1.5	-1.4	-1.3	-1.5	-1.1	-2.2	-0.4
Ever taken oral contraceptive pill	1.7	1.8	6.8	0.7	-0.1	0.7	0.6	1.4	-1.7	-2.6
Age started oral contraceptive pill	1.7	2.2	4.9	-1.7	0.3	1.6	1.3	-1.2	2.2	1.1
Respiratory disease	1.6	3.5	11.1	0.9	-3.3	1.1	0.9	1.2	-2.6	-1.6
Hand grip strength (left)	1.6	4.1	10.2	-3.2	-2.9	0.5	0.8	-2.0	-1.0	-2.1
Diabetes (mother)	1.6	2.1	6.0	-1.0	-1.2	1.5	2.4	-1.4	-0.5	-1.3
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.2	0.7	1.1	1.6	1.3	0.4	1.7	1.8
Illnesses of siblings	1.6	2.3	4.4	1.4	1.7	1.5	1.8	0.5	0.9	2.1
Medication: Ventolin 100micrograms inhaler	1.6	2.0	5.5	-0.2	-1.9	2.3	2.2	-0.3	-0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	5.2	0.8	-0.6	-2.3	-1.5	1.3	0.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.9	1.4	2.0	-0.7	-1.8	1.4	1.3	-0.2
Major Depression (MDD)	1.5	1.8	4.9	0.4	1.5	-1.7	-2.2	0.5	0.5	-1.4
Systolic Blood Pressure	1.5	7.3	22.2	-2.1	1.6	-4.7	-3.4	-1.0	2.7	1.6
Smoking Status	1.5	3.5	11.3	3.4	-0.3	2.0	1.1	2.3	-0.9	-1.4
Taking other prescription medications	1.5	2.2	7.1	2.6	0.3	1.0	0.7	2.7	-0.2	-0.6
High blood pressure	1.5	4.2	14.5	-1.4	2.2	-3.8	-1.8	-1.7	1.5	-0.3
Multivitamins +/- minerals	1.5	2.0	4.9	1.3	-0.3	-1.8	-2.2	1.1	-1.6	-0.3
Medication: Levothyroxine sodium	1.5	2.6	7.7	-1.0	1.0	2.8	1.7	-2.2	0.4	0.7
Financial difficulties in last 2 years	1.5	2.0	9.5	1.2	-1.1	-0.4	-0.3	0.2	-3.1	-1.2
Pulse rate	1.5	2.5	6.1	0.5	1.4	1.5	1.7	-0.3	2.5	2.0
Comparative body size at age 10	1.5	4.2	8.9	3.0	-2.4	1.7	2.4	2.4	-0.1	0.4
Eye problems/disorders: None of the above	1.5	1.7	6.4	1.9	-2.5	-0.2	0.1	1.2	-0.7	-0.6
Mean time to correctly identify matches	1.5	2.8	5.7	-0.7	2.3	-2.3	-2.4	-0.0	1.5	0.8
Medication for cholesterol	1.5	2.3	5.4	1.3	-1.5	2.3	1.4	2.2	0.1	0.4
Alzheimer’s Disease (in father)	1.4	1.5	4.5	-1.3	0.5	2.1	0.8	-1.6	-1.0	-0.1
Systolic blood pressure, automated reading	1.4	4.1	9.4	-1.0	1.1	-2.9	-2.3	0.3	3.1	1.9
Number of incorrect matches in round	1.4	2.3	6.9	0.7	0.8	-2.6	-2.6	0.0	-1.1	0.1
Wears glasses or contact lenses	1.4	1.6	3.3	0.3	-0.8	1.7	1.8	1.5	1.5	0.1
Vascular/heart problems diagnosed by doctor	1.4	3.8	11.2	1.3	-2.2	3.3	1.6	1.9	-1.5	0.4
Impedance of whole body	1.4	7.2	16.6	-1.6	3.8	-2.5	-2.4	-0.7	4.1	2.1
Ever had hysterectomy (womb removed)	1.3	1.4	3.1	1.4	-1.3	1.8	1.0	0.6	-1.2	-0.5
High blood pressure (mother)	1.3	1.8	4.9	-1.8	-0.3	-1.2	-0.9	-2.2	-1.3	-0.7
Birth weight	1.3	2.9	8.6	0.5	-0.2	2.8	2.9	1.6	0.3	-0.9
Medication: Gliclazide	1.3	1.5	3.1	-1.1	-0.1	1.4	0.8	-1.7	-1.8	-0.8
Medication: Bendroflumethiazide	1.3	2.0	6.6	0.1	0.4	-2.6	-1.7	-0.5	-0.6	-1.9
Commuting to job workplace: Cycle	1.3	1.6	5.8	0.4	2.4	1.4	0.9	-0.7	1.1	0.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.1	1.4	0.9	0.2	-0.4	1.2	2.3	1.3
Current tobacco smoking	1.2	2.0	3.6	1.9	-0.8	1.5	1.7	0.8	-1.8	-0.8
Alcohol usually taken with meals	1.2	1.9	4.2	0.8	1.2	-1.3	-1.4	1.8	2.0	0.3
Ever highly irritable/argumentative for 2 days	1.2	1.5	5.1	0.2	-0.1	2.3	1.7	0.2	-1.2	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.7	0.8	-0.5	1.4	1.5	0.2	2.2	0.3
Health satisfaction	1.2	1.6	4.5	1.0	0.9	-2.1	-2.0	0.3	0.4	-0.6
Smoking status: Previous	1.2	1.8	4.4	1.8	1.3	0.7	0.1	2.1	1.5	-0.6
Smoking status: Current	1.2	1.9	3.9	1.8	-1.1	1.4	1.6	0.4	-2.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.1	2.3	-1.0	1.7	1.2	1.9	1.0	1.5
Ever smoked	1.2	2.2	6.4	2.5	-0.1	1.4	1.4	1.5	-0.1	-1.6
Supplements: Calcium	1.2	1.3	3.7	1.6	0.7	-1.0	-1.1	1.9	0.4	0.1
Basal cell carcinoma (self-reported)	1.2	1.4	3.3	1.6	1.2	-1.0	-1.8	1.1	0.0	0.1
Reaction Time	1.1	2.1	6.5	-0.3	2.5	-1.8	-1.7	-0.0	1.3	0.5
Ovarian Cancer	1.1	1.5	6.0	0.3	-1.0	-0.7	-0.8	-0.2	-1.4	-2.5
Ulcerative Colitis	1.1	1.6	4.8	1.6	0.9	-0.6	-0.4	1.2	2.2	1.0
Hand grip strength (right)	1.1	3.0	7.1	-2.7	-2.5	0.5	0.5	-1.6	-1.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	7.1	0.6	-0.7	0.0	-0.5	-0.5	-2.7	-1.4
Age when periods started (menarche)	1.1	2.5	6.2	1.5	1.6	-0.5	-0.1	0.8	2.5	2.5
Serious illness, injury or assault to yourself	1.1	1.4	5.6	0.3	0.6	1.5	0.8	-0.3	2.4	-0.8
Past tobacco smoking	1.1	2.0	5.9	-2.4	-0.6	-1.2	-1.0	-1.8	-0.8	1.3
Falls in the last year	1.1	1.5	3.0	1.7	1.1	-1.5	-1.6	0.8	-0.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	5.1	0.7	1.5	2.3	1.3	1.0	0.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.1	-0.6	0.6	-1.7	-1.2	-0.8	-1.4	-1.2
Pulse rate, automated reading	1.1	3.5	13.9	-0.4	0.2	1.8	2.5	-0.0	3.7	1.1
Chest pain or discomfort	1.1	1.6	4.2	-1.1	-1.0	2.0	1.7	-0.4	-1.2	-0.2
Age at last live birth	1.1	1.7	4.3	-2.1	-0.5	0.3	1.8	-1.9	-0.3	0.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	5.0	-1.1	-0.8	0.7	1.1	-2.2	-0.8	-0.2
Commuting to job workplace: Walk	1.1	1.2	3.2	-1.6	0.7	-0.1	0.0	-1.2	1.8	0.6
Alzheimer’s Disease (including proxy)	1.0	1.5	3.5	-0.6	0.2	1.7	-0.2	-0.6	-1.9	-1.7
Mean Putamen Volume	1.0	1.2	4.5	1.2	1.2	0.0	-0.2	0.7	-0.5	-2.1
Blood Platelet Count	1.0	11.4	28.6	-3.2	-3.0	-2.3	-1.9	-5.3	-4.8	-0.5
Chronic bronchitis/emphysema (father)	1.0	1.2	3.3	1.6	-0.4	0.7	0.8	1.8	0.4	-1.1
Happiness	1.0	1.2	2.5	-0.6	1.6	-1.5	-1.5	-0.9	-0.1	-0.6
Noisy workplace	1.0	1.2	2.8	0.7	0.0	1.0	0.6	1.7	-1.2	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.1	-0.4	1.3	1.3	1.4	0.2	0.2	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.6	0.4	1.9	-1.5	-1.1	-0.5	1.2	-0.3
Depression (self-reported)	1.0	1.2	3.7	1.9	-0.2	-0.3	-1.1	1.1	-1.6	-0.3
Leg fat percentage (right)	1.0	3.6	9.6	1.1	0.5	3.1	3.0	1.0	1.7	1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	5.7	-1.1	0.6	-0.1	-0.2	-0.5	1.1	2.4
Myopia	1.0	1.5	2.2	1.2	1.5	0.8	1.1	1.2	1.5	1.1
Body Mass Index (BMI) (2010)	0.9	1.3	2.8	1.2	-1.6	-0.3	-0.7	1.0	-1.7	-0.9
BMI	0.9	5.4	16.5	1.4	-1.9	3.8	4.1	0.6	-1.1	-0.1
Average weekly spirits intake	0.9	1.1	2.7	-0.3	-0.9	1.6	1.3	0.1	1.1	-1.1
Forced vital capacity (FVC)	0.9	3.3	8.0	1.1	-1.1	2.8	2.6	1.5	0.1	-1.9
Mouth/teeth dental problems: Dentures	0.9	1.5	5.3	-1.4	-1.5	0.6	0.5	-2.3	0.6	0.3
Gout (self-reported)	0.9	1.3	3.0	-0.4	-1.3	1.5	1.7	-1.0	-0.8	0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.4	-0.8	1.0	2.1	0.8	-1.9	1.1	0.8
Exposure to tobacco smoke outside home	0.9	1.2	2.7	-1.6	-0.2	-1.3	-1.0	-1.1	0.5	1.3
Number of full brothers	0.9	1.1	2.7	-1.4	-1.0	-1.6	-0.4	-0.0	-1.2	-0.5
Age at first live birth	0.9	1.7	5.8	-2.4	-0.1	0.2	1.1	-2.2	-0.1	0.1
Emphysema/chronic bronchitis	0.9	1.1	3.1	1.0	0.6	-0.4	-0.0	1.7	-0.2	-1.8
Medication: Blood pressure	0.9	1.7	3.8	0.5	1.5	-1.7	-0.9	0.6	2.0	1.0
Medication: Omeprazole	0.9	1.1	2.1	1.4	0.2	0.2	-0.5	1.5	1.4	1.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.9	-0.4	0.1	0.2	0.5	-0.5	1.8	2.0
Qualifications: nursing, teaching	0.9	1.4	2.9	-1.2	0.7	0.8	1.7	-0.9	1.3	1.1
Miserableness	0.9	1.5	4.1	2.0	0.1	-0.2	-1.0	1.3	-0.9	-1.7
Medication: Lisinopril	0.9	1.1	4.2	0.2	0.0	-0.9	-1.0	-0.6	-1.2	-2.0
Coronary Artery Disease (CAD)	0.8	1.0	3.0	0.2	1.2	-1.7	-1.2	0.3	1.0	-0.3
Blood Eosinophil Count	0.8	6.0	16.9	1.4	-4.1	2.7	3.2	1.6	-0.9	-1.3
Number of treatments/medications taken	0.8	1.5	3.2	1.5	1.4	-1.8	-1.5	0.4	0.3	0.4
Relative age of first facial hair	0.8	1.7	3.7	1.6	-1.8	-0.7	0.4	1.3	-1.9	-0.2
Medication: Co-codamol	0.8	0.9	3.3	-0.7	1.0	-0.6	-0.7	-1.8	-0.1	0.8
Trunk fat percentage	0.8	3.1	8.5	-0.0	2.6	0.7	0.7	-0.2	2.9	2.4
Townsend deprivation index at recruitment	0.8	1.1	2.5	0.3	-0.5	1.2	1.6	-0.5	-1.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	5.3	-0.6	1.1	-0.6	-0.8	-0.9	-0.5	-2.3
Medication: Ramipril	0.8	1.1	1.9	1.0	1.4	-1.1	-1.4	0.1	0.8	0.9
Time employed in main current job	0.8	0.9	3.0	-1.3	0.9	0.8	0.5	-1.7	0.2	-0.0
Headache pain in last month	0.8	1.3	3.5	0.7	1.2	-1.9	-1.5	0.6	1.1	0.5
Worry too long after embarrassment	0.8	1.3	3.1	-1.8	1.3	1.2	0.7	-0.6	-0.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	1.5	0.3	0.9	0.9	1.5	0.2	-1.2
Had major operations	0.8	1.0	3.8	0.1	0.7	1.2	0.9	0.1	2.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	6.4	0.3	2.5	0.5	0.7	0.3	0.8	0.7
Leg fat percentage (left)	0.8	2.9	8.0	1.0	0.4	2.8	2.6	0.9	1.4	1.4
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.3	0.7	0.4	1.8	1.2	1.0	-0.6	-0.2
Unable to work because of sickness or disability	0.8	1.0	3.8	0.4	-0.2	-0.3	-1.2	0.1	-2.0	-1.1
Sensitivity / hurt feelings	0.7	1.2	2.1	-1.1	1.0	-1.0	-1.2	-1.1	0.1	-1.4
Medication for hormone replacement therapy	0.7	0.7	2.7	1.6	0.5	-0.9	-0.6	0.8	0.4	0.7
Maternal smoking around birth	0.7	1.1	5.5	0.5	-0.4	0.7	0.9	-0.4	-2.3	-0.1
Impedance of leg (left)	0.7	3.3	9.9	-1.2	2.9	-0.6	-0.6	-0.3	3.1	1.7
Hair/balding pattern: Pattern 3	0.7	1.0	3.6	-0.4	-0.1	-1.4	-1.9	0.3	-0.6	-1.0
Lung cancer (father)	0.7	0.8	2.9	0.4	0.5	-0.7	-1.7	0.1	-1.3	0.3
Arm fat-free mass (right)	0.7	3.7	7.0	-0.2	-1.6	2.6	2.6	-0.7	-2.1	-2.2
Angina (self-reported)	0.7	0.9	2.0	0.6	0.1	-1.4	-1.3	1.2	0.8	0.4
Migraine (self-reported)	0.7	0.9	1.8	-0.2	1.1	0.5	1.3	0.9	1.3	0.7
Medication: Ibuprofen	0.7	0.9	2.4	0.2	1.1	-1.6	-1.0	-0.8	0.7	-0.2
Arm predicted mass (right)	0.7	3.6	6.7	0.1	-1.7	2.6	2.5	-0.7	-2.0	-2.3
Number of full sisters	0.7	0.8	1.9	-0.1	-1.4	0.5	0.1	0.5	-1.3	-1.2
Illnesses of father: Heart disease	0.7	1.0	3.1	-0.7	-0.5	-1.1	-1.8	0.5	-0.7	-1.0
Back pain experienced in last month	0.7	1.1	3.1	1.0	-1.0	-0.2	-0.3	-0.0	-1.8	-1.5
Average weekly champagne plus white wine intake	0.7	1.0	3.6	-0.6	-0.6	1.4	1.9	-0.5	0.4	-0.5
High cholesterol (Self-reported)	0.7	1.2	2.8	1.7	1.6	0.4	0.4	0.7	1.2	1.1
Arm fat-free mass (left)	0.7	3.3	7.9	-0.3	-1.3	2.8	2.4	-1.2	-1.8	-1.7
Average weekly beer plus cider intake	0.7	1.0	2.5	1.0	-1.4	0.8	0.3	1.0	-1.6	-0.2
Risk taking	0.7	1.0	2.4	0.3	-0.9	-1.3	-1.3	-0.0	-1.5	-0.7
Heart disease (siblings)	0.7	0.9	2.2	-0.7	-1.2	-1.3	-1.5	-0.1	0.2	-0.6
Arm predicted mass (left)	0.7	3.6	7.1	-0.2	-1.5	2.7	2.3	-1.0	-2.2	-2.1
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.8	0.5	-0.4	2.2	1.3	0.6	1.1	1.1
Rheumatoid Arthritis	0.6	0.9	2.5	-0.4	0.9	-1.2	-1.6	-0.8	-0.8	-0.0
Cardiovascular Disease	0.6	2.1	5.3	-0.7	1.9	-2.3	-1.1	-1.3	1.3	-0.6
Hypothyroidism (self reported)	0.6	1.3	4.6	-0.4	0.4	2.1	1.2	-1.4	1.0	0.3
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.5	-0.1	1.9	-0.6	-1.2	-0.6	-0.5	0.4
Medication: Metformin	0.6	0.9	2.8	-1.1	0.0	-0.7	-0.8	-1.7	-1.1	-0.2
Severe depression (siblings)	0.6	0.7	1.2	1.1	-0.8	0.6	0.6	0.6	-1.1	-1.0
Impedance of leg (right)	0.6	2.8	10.0	-0.9	2.6	-0.2	-0.1	0.0	3.2	1.4
Fed-up feelings	0.6	1.0	2.6	1.0	1.5	0.3	0.1	0.9	-0.7	-1.6
Stomach or abdominal pain in last month	0.6	0.8	2.3	1.5	0.4	0.4	-0.2	1.4	0.3	0.7
Allergy	0.6	1.3	5.4	-0.5	1.2	-0.2	0.4	-0.9	2.3	0.9
Diabetes (self-reported)	0.6	1.0	2.8	-0.4	-0.2	-0.7	-1.3	-1.7	-1.3	0.1
Trunk fat-free mass	0.6	3.4	5.1	-1.1	-1.2	2.3	2.0	-1.7	-2.1	-2.2
Trunk predicted mass	0.6	3.5	5.8	-1.0	-1.3	2.4	2.2	-1.6	-2.0	-2.1
Breastfed as a baby	0.6	0.7	2.0	0.8	-1.3	-0.5	-0.1	0.5	-1.4	-0.4
Peak expiratory flow (PEF)	0.6	1.4	3.2	1.2	0.5	1.2	1.4	1.1	-1.8	-0.7
Glaucoma (self-reported)	0.6	0.7	2.2	0.7	0.6	1.5	1.0	-1.0	-0.3	0.2
Forced vital capacity (FVC), Best measure	0.6	2.0	5.6	1.1	-0.8	2.4	2.2	0.9	-0.0	-1.0
Body fat percentage	0.6	2.3	5.2	0.1	1.8	1.6	1.5	0.0	2.3	1.8
Medication: Allopurinol	0.6	0.8	1.4	-0.7	-1.0	0.2	0.8	-1.2	-0.8	1.1
Leg fat mass (right)	0.6	2.2	7.8	0.3	0.2	2.8	2.7	-0.0	0.4	0.5
Long-standing illness, disability or infirmity	0.6	0.8	2.9	1.2	-0.1	0.8	0.4	0.2	-0.7	-1.7
Osteoarthritis (self-reported)	0.6	0.7	2.1	1.0	-1.4	0.4	-0.1	0.6	-0.9	-0.9
Guilty feelings	0.6	0.9	3.6	0.2	-0.3	0.7	1.1	0.2	-0.8	-1.9
Financial situation satisfaction	0.6	0.7	1.6	-0.8	0.6	-1.3	-0.8	-1.1	-0.6	0.3
Medication: Paracetamol	0.6	1.0	2.6	1.3	0.4	-1.4	-0.8	1.6	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	1.4	0.0	-0.6	-1.0	1.2	-0.3	0.7
Crohns Disease (2012)	0.5	0.8	2.0	-0.3	-1.3	-1.1	-1.4	-0.8	-0.3	-0.5
LDL Cholesterol	0.5	0.8	1.8	0.3	1.3	-0.7	-1.0	0.2	1.0	1.0
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.3	0.3	-0.6	0.1	-0.7	0.7	-0.2	-1.5
Lung FEV1/FVC ratio	0.5	2.4	6.4	2.5	2.0	-0.2	-1.1	0.2	-0.7	2.3
Tanning	0.5	6.0	16.6	-2.4	-4.1	0.0	1.8	-2.5	2.5	2.0
Hearing difficulty/problems: Yes	0.5	0.7	1.6	0.8	-0.4	0.7	1.0	1.3	0.7	0.9
Vitamin and mineral supplements	0.5	0.7	2.0	-0.5	0.6	1.1	1.4	-0.2	0.9	0.2
Trunk fat mass	0.5	2.1	4.0	-0.2	2.0	1.5	1.4	-0.4	2.0	1.5
Waist circumference	0.5	2.0	4.3	0.9	1.7	2.1	1.6	0.5	1.5	0.8
Had other major operations	0.5	0.6	1.2	-0.1	-1.0	1.0	0.6	-1.1	-0.5	-0.7
Fluid intelligence score	0.5	1.1	3.2	1.1	-1.8	1.1	0.9	1.0	0.1	-0.3
Worrier / anxious feelings	0.5	1.0	2.6	-0.0	-0.2	1.6	1.4	-0.1	-0.3	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.2	1.6	-0.4	1.8	1.5	1.4	-0.4	-1.1
Medication: Lansoprazole	0.5	0.6	1.7	1.3	0.4	0.2	-0.3	1.3	0.1	-0.7
Tense / ‘highly strung’	0.5	0.8	2.4	-0.7	1.5	-0.5	-0.7	-0.1	-0.5	-1.3
Pulse wave reflection index	0.5	0.6	3.1	0.1	-0.8	-0.3	0.2	0.1	-0.7	-1.8
Loud music exposure frequency	0.5	0.6	1.5	-0.9	-0.7	0.2	-0.2	-1.2	-0.4	-0.8
Medication: Amlodipine	0.5	0.8	2.3	-1.5	0.3	-1.1	-0.2	-1.1	-0.7	-0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.0	-0.4	0.0	-0.6	-0.1	-1.3	0.4	1.4
Shortness of breath walking on level ground	0.5	0.6	0.9	0.6	0.9	0.8	0.8	0.0	-0.9	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-0.9	-1.3	1.2	1.1	-0.6	-0.8	0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.7	1.3	-0.9	0.7	0.9	0.5	0.0	0.5
Comparative height size at age 10	0.5	2.8	6.3	-2.5	1.8	-0.5	-1.5	-1.8	2.2	-0.4
Leg pain on walking	0.5	0.7	2.1	-0.0	-0.6	-0.0	0.0	-0.5	-1.4	-1.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.2	-1.2	1.1	1.1	0.4	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.5	-0.7	0.9	0.6	0.3	-1.9	-1.4	-0.6
Whole body fat-free mass	0.5	2.7	4.1	-0.8	-1.1	2.0	1.8	-1.5	-2.0	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.6	0.0	-0.3	-0.8	0.1	-1.0	-1.3	-0.7
Friendships satisfaction	0.5	0.6	1.0	-0.9	0.1	1.0	0.8	-0.8	-0.5	-0.8
Whole body water mass	0.5	2.9	4.3	-0.8	-1.1	2.1	1.9	-1.5	-2.0	-2.0
Irritability	0.5	0.9	2.6	-0.1	1.6	-1.4	-1.1	-0.5	0.3	0.3
Leg fat mass (left)	0.5	2.0	7.5	0.3	0.2	2.7	2.5	-0.1	0.3	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.2	1.5	0.4	0.6	-0.1	1.5	-0.3	-1.1
Schizophrenia (2018)	0.4	0.8	2.6	0.2	-0.9	0.2	1.1	0.5	-1.0	-1.6
Prostate Cancer	0.4	0.6	1.9	0.6	-0.1	-0.3	-0.5	0.7	-1.1	-1.4
HbA1C	0.4	0.4	1.0	0.1	1.0	-0.2	-0.7	-1.0	-0.1	0.7
Blood White Count	0.4	3.2	6.7	2.6	-1.4	0.9	2.0	2.6	-0.4	-1.4
Chronotype (morning person)	0.4	0.8	3.2	-1.8	-0.0	-0.5	-0.5	-1.3	-0.3	-0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.5	0.4	-0.6	0.7	0.2	0.1	-1.6	-0.1
Angina	0.4	0.5	1.3	0.6	-0.2	-0.8	-0.6	1.2	0.8	0.3
Relative age voice broke	0.4	0.6	2.3	0.8	-0.5	0.2	0.1	0.9	-1.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.0	-0.9	-1.4	1.1	1.1	0.2	-0.2	-0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.4	0.1	0.1	-0.4	-1.3	0.3	-1.9	-0.7
Body mass index (BMI)	0.4	1.8	5.5	1.3	-0.4	2.3	2.2	0.7	-0.4	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	0.7	1.3	0.2	-0.2	-0.0	-0.8	0.7
Had menopause	0.4	0.6	1.2	0.1	-0.9	0.5	-0.4	0.6	1.0	1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	0.2	1.2	0.2	-0.8	1.0	0.6	-0.3
Mouth/teeth dental problems	0.4	0.6	1.5	0.2	-1.1	-0.1	0.6	0.6	-1.2	-0.9
Medication: Simvastatin	0.4	0.6	2.1	-0.1	0.1	0.7	0.9	-1.4	-0.0	0.9
Neuroticism score	0.4	0.8	3.5	0.2	0.6	0.2	0.3	0.1	-1.2	-1.9
Arm fat percentage (right)	0.4	1.6	3.9	-0.2	1.7	1.0	0.8	-0.5	2.0	1.8
Alcohol intake versus 10 years previously	0.4	0.6	1.4	0.9	0.2	0.8	0.7	0.5	-0.8	-1.2
Father’s age at death	0.4	0.5	1.0	0.1	0.6	1.0	0.5	0.3	0.9	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	0.7	0.9	0.3	-0.9	0.8	-0.7	-0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.1	-0.3	-0.7	1.1	1.8	-0.7	0.2	-0.6
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	-0.2	1.0	0.4	0.9	-0.7	1.0	-0.5
Length of working week for main job	0.4	0.5	3.1	-0.1	-1.7	-0.3	0.0	-0.3	-0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.8	0.3	1.0	-0.5	-1.3	-0.0	0.3	0.3
Blood clot in the leg (DVT)	0.4	0.6	1.7	1.3	-0.1	-0.3	-0.7	1.2	-0.4	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	-0.2	-1.4	0.6	-0.0	0.1	-1.4	-0.4
Pulse wave peak to peak time	0.4	0.5	1.4	-0.0	-1.2	-0.3	-0.8	0.5	-0.9	0.3
Whole body fat mass	0.4	1.6	3.8	-0.2	1.3	2.0	1.8	-0.5	1.1	1.0
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-0.1	-1.0	0.5	-0.2	0.1	-0.9	-1.2
Arm fat percentage (left)	0.4	1.5	3.5	-0.0	1.5	1.1	1.1	-0.2	1.9	1.5
Loneliness, isolation	0.4	0.6	1.3	-0.8	0.7	-0.0	0.9	-0.7	-1.1	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	1.9	-0.1	-0.4	-0.3	0.1	-0.9	-0.1	1.4
Commuting to job workplace: Public transport	0.4	0.4	0.8	0.7	0.7	-0.8	-0.1	-0.8	0.3	0.9
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	-0.6	0.6	1.2	0.6	-0.8	-0.1	0.6
Illnesses of father: High blood pressure	0.4	0.4	1.3	-1.0	-0.6	-0.3	0.4	0.2	0.1	-1.2
Basal metabolic rate	0.4	2.3	4.8	-0.7	-0.6	2.2	2.0	-1.4	-1.6	-1.5
Number of operations (self-reported)	0.4	0.6	1.7	0.3	0.3	1.3	0.6	0.3	0.8	-1.1
Ever depressed for a whole week	0.4	0.5	1.1	-0.2	0.1	-0.3	-1.0	1.1	-0.4	-1.0
Alcohol drinker status: Previous	0.4	0.4	1.3	0.9	-0.1	1.1	0.4	0.9	-0.1	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	1.3	-0.3	-0.1	0.4	0.0	0.6	0.9
Crohns Disease (2017)	0.3	0.6	2.1	-0.8	-0.6	-0.5	-0.6	-1.4	0.5	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.4	1.1	0.4	-0.4	-0.3	0.7	1.2	-0.4
Age at First Birth	0.3	0.5	1.6	0.3	0.5	0.1	-0.5	1.3	-1.1	-0.0
Bipolar Disorder (2011)	0.3	0.2	1.0	0.3	-0.5	-0.3	-0.1	1.0	0.3	-0.5
HDL Cholesterol	0.3	0.6	1.5	-0.6	0.3	-0.1	0.8	-1.2	1.2	0.0
Lupus	0.3	0.5	1.3	0.9	-0.3	-0.1	-0.4	0.6	0.8	1.1
Neuroticism (2016)	0.3	0.4	1.3	-0.8	1.1	-0.1	0.0	-1.0	-0.1	-0.3
Height	0.3	6.7	15.4	-3.9	3.6	-2.0	-2.5	-2.2	1.6	-0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	0.4	0.2	-0.5	-0.9	-1.4	-0.8	-0.1
Neuroticism	0.3	0.6	3.2	-0.0	-0.4	-0.2	-0.2	0.3	-1.0	-1.8
Hair Pigment	0.3	8.9	25.8	1.1	-2.8	1.4	0.8	1.8	-5.1	-4.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	0.9	0.3	0.5	0.2	0.4	-0.5	-1.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.8	0.9	0.2	0.2	-0.6	-0.3	0.3
Leg fat-free mass (left)	0.3	1.4	2.2	-0.5	-0.6	1.5	1.4	-1.2	-1.4	-1.2
Qualifications: CSEs or equivalent	0.3	0.3	1.2	-0.9	-0.4	0.1	0.3	-1.1	0.1	-0.2
Leg predicted mass (left)	0.3	1.4	2.2	-0.5	-0.7	1.5	1.3	-1.2	-1.5	-1.2
Weight	0.3	1.3	5.0	-0.0	0.5	2.2	1.9	-0.5	0.1	-0.1
Hip circumference	0.3	1.1	3.6	0.4	0.3	1.9	1.8	-0.1	-0.9	0.3
Prospective memory result	0.3	0.4	1.1	0.3	0.2	0.7	0.7	0.3	0.7	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.8	1.7	0.1	1.3	0.9	1.0	-0.2	-0.0
Arm fat mass (right)	0.3	1.1	3.1	-0.1	1.0	1.8	1.4	-0.6	0.8	0.7
Standing height	0.3	3.2	8.9	-3.0	2.2	-0.1	-0.4	-2.6	1.0	-0.8
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.2	0.3	0.3	0.9	-0.9	-0.6	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	0.1	-0.1	0.9	1.0	-1.0	-0.3	0.4
Medication: Paracetamol	0.3	0.5	1.3	1.1	0.3	-0.9	-0.4	1.2	-0.3	-0.1
Neck or shoulder pain in last month	0.3	0.5	1.4	-1.2	0.5	0.4	0.3	-0.5	0.8	-0.8
Overall health rating	0.3	0.7	2.9	1.7	0.4	-0.6	-0.3	0.5	0.0	-1.0
Knee pain experienced in last month	0.3	0.5	1.2	-0.2	-0.6	0.2	-0.1	-0.7	-1.1	-1.0
Leg fat-free mass (right)	0.3	1.4	3.0	-0.6	-0.6	1.1	0.9	-1.5	-1.7	-1.3
Mood swings	0.3	0.6	2.1	0.1	1.5	0.1	0.3	-0.7	-1.1	-0.3
Ever had bowel cancer screening	0.3	0.4	0.9	0.6	1.0	0.2	-0.7	-0.6	-0.7	0.1
Diabetes diagnosed by doctor	0.3	0.5	2.1	-0.1	0.0	-0.3	-0.8	-0.7	-1.5	-0.4
Eye problems/disorders: Cataract	0.3	0.4	1.3	-0.2	1.1	0.1	0.3	0.6	-0.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	-0.1	-0.1	-0.9	-0.4	0.3	-0.8	-1.0
Breast cancer (self-reported)	0.3	0.4	1.3	0.2	-0.4	0.4	-0.2	-0.7	-0.5	-1.1
Leg predicted mass (right)	0.3	1.5	3.0	-0.7	-0.6	1.1	0.9	-1.6	-1.7	-1.3
Arm fat mass (left)	0.3	1.4	3.5	-0.2	1.0	1.9	1.7	-0.6	0.9	0.9
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	1.2	1.0	0.2	0.2	1.0	0.6	-0.2
Mother’s age at death	0.3	0.4	1.1	-0.3	-0.7	0.3	0.9	1.0	0.2	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	0.3	0.9	-0.4	-1.1	0.1	-0.0	0.2
Alcohol drinker status: Never	0.3	0.4	1.2	-0.7	-0.8	-0.2	-0.3	0.1	1.1	0.4
Pain experienced in last month	0.3	0.5	1.3	0.5	-1.1	0.9	0.6	0.6	-0.6	0.2
Bipolar Disorder (2018)	0.2	0.4	0.9	0.2	0.4	-0.9	-0.8	0.1	1.0	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	2.3	0.2	-0.4	-0.4	0.3	0.5	-0.1	-1.5
Depression (Nagel 2018)	0.2	0.3	0.9	0.3	0.5	-0.2	-0.7	-0.1	0.0	-0.9
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	0.8	-0.5	-0.5	-0.6	0.1	1.3	-0.2
Fasting Glucose	0.2	0.2	0.9	0.3	0.4	-0.9	-0.2	0.4	-0.2	-0.4
Schizophrenia (2014)	0.2	0.4	0.9	0.4	-0.7	-0.5	0.9	0.4	-0.6	-1.0
Blood Red Count	0.2	1.6	3.9	-0.4	-0.4	2.0	1.8	1.0	-0.3	1.5
Heel T-Score	0.2	1.4	7.6	0.6	0.4	-0.5	-0.7	1.0	2.8	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	0.1	0.2	1.0	0.6	-0.4	0.5	0.5
Nervous feelings	0.2	0.5	1.2	-0.7	0.5	0.3	0.1	-0.8	-1.1	-0.7
Pain all over the body in last month	0.2	0.2	1.0	-0.3	-1.0	0.0	0.4	-0.5	-0.1	-0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.3	0.2	-1.0	-0.7	0.6	0.4	0.2
Medication: Cholesterol lowering	0.2	0.4	1.6	0.7	1.3	-0.5	-0.0	0.0	0.3	0.4
Number of children fathered	0.2	0.2	0.3	0.4	0.5	-0.3	-0.4	0.5	-0.0	0.5
Qualifications: College or University degree	0.2	0.7	1.9	-0.2	-0.2	0.5	1.4	0.8	0.4	1.2
Suffer from ‘nerves’	0.2	0.3	1.3	-0.3	1.1	-0.3	-0.7	-0.2	0.0	-0.1
Family relationship satisfaction	0.2	0.2	0.5	-0.7	0.4	-0.2	-0.3	-0.7	-0.2	-0.6
Medication: Aspirin	0.2	0.3	0.7	-0.6	0.8	-0.3	-0.4	-0.7	0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	0.2	0.2	0.2	-0.1	-0.0	-0.8	-1.0
Medication: Atorvastatin	0.2	0.3	1.4	-0.4	-0.1	-0.5	-0.1	-0.4	-0.3	-1.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	0.7	-0.1	0.8	0.2	0.8	0.7	0.2
Neuroticism (Nagel 2018)	0.1	0.3	1.2	-0.0	0.6	0.1	-0.5	0.1	-0.1	-1.1
Breast Cancer	0.1	0.3	0.9	0.3	-0.6	-1.0	-0.3	0.6	0.5	0.1
Triglycerides	0.1	0.2	0.4	0.5	0.4	0.0	-0.6	0.5	-0.1	0.4
Allergy or Eczema	0.1	0.4	1.3	-0.0	0.5	-0.8	-1.1	0.2	-0.7	-0.0
Diabetes (father)	0.1	0.2	0.4	0.0	0.6	0.5	-0.2	0.4	-0.4	-0.5
Pack years adult smoking proportion	0.1	0.2	0.4	0.1	-0.5	-0.3	-0.4	0.5	-0.7	-0.5
Supplements: Glucosamine	0.1	0.1	0.2	0.5	-0.0	-0.2	-0.4	-0.2	-0.1	0.5
Sitting height	0.1	1.0	5.6	0.3	-0.5	-0.0	0.0	0.2	-1.0	-2.4
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.4	-0.5	-0.0	0.2	0.1	0.6	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.5	-0.2	-0.2	0.1	0.0	1.2	-0.0	-0.6
Qualifications: None of the above	0.1	0.2	0.6	0.5	0.0	-0.5	-0.8	-0.2	-0.4	-0.2
Hair/balding pattern: Pattern 4	0.1	0.4	1.0	0.6	0.5	0.2	0.2	-0.2	1.0	0.9
Alcohol intake frequency.	0.1	0.3	0.9	0.4	0.1	-0.5	-0.9	0.2	-0.7	0.4
Medication: Aspirin	0.1	0.2	0.3	-0.3	0.5	-0.3	-0.5	-0.5	-0.3	-0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.8	0.0	0.1	-0.1	-0.9	-0.4	-0.0	0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.6	-0.3	-0.8	-0.2	0.1	0.1	0.0	0.7
Cholesterol lowering medication	0.1	0.2	0.3	0.5	-0.5	-0.4	-0.4	-0.2	-0.1	-0.6
Pack years of smoking	0.1	0.1	0.4	-0.2	-0.6	-0.2	-0.4	0.6	-0.1	-0.3
Worry (Nagel 2018)	0.0	0.1	0.4	-0.1	-0.1	-0.0	0.1	-0.1	-0.0	-0.6
Supplements: Vitamin C	0.0	0.1	0.1	0.3	-0.1	0.2	-0.3	0.2	-0.3	0.2
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	-0.1	-0.4	0.3	0.0	-0.2	0.1

Hub : Genes

CDC42EP3

Models

Trait associations