Hub : Genes

STRN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1870	0.0630	0.00100	0.029	NA	0.011	NA	0.015	6.8e-03	NA	0.07000	NA	0.04000
2	GTEx	Heart Left Ventricle	0.1603	0.0487	0.00033	0.060	NA	0.043	NA	0.046	3.8e-04	NA	0.00240	NA	0.00170
3	METSIM	Adipose	0.0694	0.0229	0.00003	0.032	0.033	0.022	0.032	0.021	1.3e-05	8.3e-06	0.00021	1.4e-05	0.00038
4	TCGA	Breast Invasive Carcinoma	0.0384	0.0189	0.00300	-0.001	0.004	0.008	NA	0.000	5.7e-01	4.4e-02	0.00800	NA	0.24000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.4	2.2	4.9	0.6	1.8	0.4	-2.2
Bipolar Disorder or Schizophrenia	1.5	3.7	6.0	1.3	2.4	1.6	-2.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.0	0.2	0.8	-0.3
Depression (Nagel 2018)	0.2	0.4	1.2	0.3	-0.1	1.1	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	0.6	0.4	1.0	0.3
Neuroticism (Nagel 2018)	0.2	0.5	1.6	-0.0	0.6	1.3	-0.0
Schizophrenia (2018)	1.0	2.1	3.1	1.2	1.7	1.8	-0.9
Schizophrenia vs Biploar Disorder	0.9	1.2	2.4	-1.1	1.6	-0.6	0.8
Worry (Nagel 2018)	0.5	1.1	2.1	-1.2	0.1	0.8	-1.5
Alzheimer’s Disease (in mother)	0.8	0.9	1.4	-1.0	1.0	-1.2	-0.6
Alzheimer’s Disease (in father)	0.5	0.6	1.1	1.0	1.1	-0.0	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.8	2.5	-0.7	0.6	-1.6	-0.0
Crohns Disease (2017)	1.7	3.7	9.8	3.1	0.4	1.8	1.2
Irritable Bowel Disease (IBD)	0.9	2.2	5.4	2.3	-0.3	1.0	1.5
Ulcerative Colitis (UC)	0.4	0.8	1.4	0.4	-1.1	-0.6	1.2
Major Depression (MDD)	1.5	1.9	5.6	2.4	0.3	1.0	0.8
Reaction Time	1.0	1.9	3.8	1.9	1.4	1.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.3	-0.4	0.1	0.6
Breast Cancer	0.2	0.5	0.9	1.0	-0.4	0.5	0.9
Ovarian Cancer	0.7	0.9	2.5	-1.6	-0.7	-0.7	0.3
Prostate Cancer	2.6	3.6	8.0	1.7	2.8	0.6	-1.8
Age at First Birth	0.4	0.6	1.4	-0.4	1.2	0.9	0.3
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	0.4	0.3	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	3.0	0.2	-0.6	-1.7	1.2
Coronary Artery Disease (CAD)	1.2	1.4	4.2	-0.0	-2.0	-1.2	-0.3
Crohns Disease (2012)	1.2	1.9	4.5	2.1	0.8	1.1	1.2
Mean Putamen Volume	1.4	1.7	3.1	-1.7	0.5	-0.5	-1.8
Fasting Glucose	1.2	1.4	4.5	0.4	2.1	1.0	0.2
HbA1C	1.0	1.2	2.6	-1.1	-0.8	-0.6	1.6
HDL Cholesterol	0.6	1.0	2.7	0.8	-0.4	1.6	0.9
LDL Cholesterol	0.3	0.5	1.0	-0.0	-1.0	-0.3	0.9
Lupus	0.1	0.2	0.3	0.5	0.5	-0.2	-0.4
Neuroticism (2016)	0.5	0.7	1.3	1.2	1.1	0.4	-0.3
Primary Biliary Cirrhosis	1.1	1.5	6.0	-0.2	-0.2	-2.4	-0.2
Rheumatoid Arthritis	0.2	0.3	0.5	0.3	0.6	0.0	-0.7
Schizophrenia (2014)	0.9	2.0	3.8	0.2	1.9	1.0	-1.8
Triglycerides	0.2	0.4	0.5	0.1	-0.7	-0.7	0.7
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.5	-0.5	-1.2	-1.6	-1.1
Ulcerative Colitis	1.9	2.8	4.6	-1.7	-1.7	-2.1	0.8
Blood Eosinophil Count	0.6	4.6	9.9	2.8	3.1	0.9	0.2
Blood Platelet Count	1.9	22.4	61.8	7.9	2.8	4.3	1.2
Blood Red Count	0.7	6.4	14.0	2.6	2.2	3.7	-0.1
Blood White Count	0.4	3.0	10.0	1.2	-3.2	-0.4	-0.8
Heel T-Score	0.3	2.5	3.8	1.3	-1.9	-1.4	1.6
BMI	0.2	1.1	3.7	-0.2	0.5	-1.9	0.7
Height	0.5	10.5	29.1	1.2	3.3	5.4	0.6
Waist Hip Ratio (WHR)	0.6	2.8	4.5	-1.4	-1.4	-1.6	-2.1
Systolic Blood Pressure	2.3	11.6	20.8	2.3	-4.6	1.9	4.1
Smoking Status	1.9	4.6	12.3	3.5	0.1	2.5	-0.1
Allergy or Eczema	1.0	2.5	8.0	2.8	0.6	1.3	-0.1
Cardiovascular Disease	1.5	5.0	10.3	1.5	-2.4	1.2	3.2
Hypothyroidism (self reported)	0.3	0.6	1.5	0.5	0.6	-1.2	-0.6
Respiratory disease	0.2	0.3	0.6	0.8	0.0	0.5	0.7
Type 2 Diabetes (T2D) (2018)	1.8	3.3	6.1	0.3	-2.5	-1.1	2.4
Lung FEV1/FVC ratio	0.8	4.1	15.3	-0.4	-1.0	-3.9	0.0
Lung FVC	1.7	8.6	16.2	1.5	3.4	4.0	-2.0
Neuroticism	0.2	0.4	0.9	-0.7	0.5	0.1	-1.0
Chronotype (morning person)	0.5	1.2	3.5	-0.6	-1.0	-1.9	0.0
Hair Pigment	0.0	1.3	4.0	0.2	-1.1	-0.0	2.0
Tanning	0.1	1.4	2.6	1.2	0.8	1.6	-1.0
Hand grip strength (left)	0.1	0.2	0.5	0.6	0.1	0.7	-0.2
Number of treatments/medications taken	0.3	0.6	1.1	0.6	-1.1	0.9	-0.1
Average weekly spirits intake	1.3	1.6	2.9	-1.5	-1.1	-1.7	0.3
Sensitivity / hurt feelings	0.1	0.2	0.5	0.2	0.3	0.7	0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	0.5	0.7	1.3	-0.5
Hearing difficulty/problems: Yes	0.6	0.9	1.8	1.1	1.4	0.7	0.1
Relative age of first facial hair	0.1	0.2	0.4	-0.6	0.4	-0.2	0.1
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	5.0	0.3	-0.5	2.1	-2.2
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.4	1.5	-1.1	1.3	0.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.8	1.0	1.3	-0.2	-0.5
Systolic blood pressure, automated reading	1.9	5.5	14.7	0.7	-3.8	0.2	2.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.9	-0.6	-0.7	-0.9	-0.9
Angina	1.1	1.5	5.2	2.3	0.2	0.8	0.2
Medication for hormone replacement therapy	4.7	5.3	15.1	2.0	-0.6	3.9	1.4
Vitamin and mineral supplements	0.2	0.3	1.1	-0.0	1.0	0.1	0.3
Supplements: Zinc	1.4	1.5	1.6	1.2	1.2	1.3	1.2
Medication: Co-codamol	0.4	0.5	0.8	0.7	-0.9	-0.3	0.7
Medication: Metformin	0.3	0.5	1.5	-0.2	-1.2	0.3	0.5
Diabetes (father)	0.9	1.1	3.0	-0.7	-0.6	-0.8	1.7
Diabetes (mother)	2.2	2.8	4.8	2.2	2.2	0.7	0.9
Severe depression (siblings)	0.2	0.2	0.4	-0.1	0.5	-0.3	0.6
Pack years adult smoking proportion	0.6	0.9	2.1	-1.0	0.7	-1.4	-0.0
Impedance of leg (right)	0.3	1.6	3.6	-0.8	-1.9	-1.4	-0.4
Leg fat-free mass (left)	0.3	1.8	4.9	0.1	2.2	0.8	1.3
Trunk fat percentage	0.4	1.4	2.5	-1.6	0.3	-1.5	0.9
Hand grip strength (right)	0.1	0.3	0.6	0.3	-0.8	0.3	0.5
Townsend deprivation index at recruitment	0.7	1.0	1.5	-0.5	-1.1	-1.0	1.2
Current tobacco smoking	0.3	0.5	0.9	1.0	0.5	0.9	-0.0
Average weekly fortified wine intake	0.4	0.5	1.3	-0.1	-1.1	-0.6	0.6
Maternal smoking around birth	0.3	0.5	1.7	1.3	0.4	-0.2	-0.2
Fed-up feelings	0.0	0.1	0.2	0.2	-0.1	0.4	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	0.8	-0.5	0.7	1.4
Relative age voice broke	1.0	1.6	4.3	-2.1	0.9	-1.0	-0.6
Taking other prescription medications	0.1	0.2	0.4	0.6	0.0	-0.6	0.1
Age when periods started (menarche)	0.3	0.7	1.2	0.6	1.1	0.8	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.0	-0.2	-0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.2	1.2	0.8	1.5	-0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	-0.1	1.0	-0.7	1.1
Qualifications: CSEs or equivalent	0.7	0.9	1.6	1.3	-1.2	-0.6	0.4
Serious illness, injury or assault to yourself	0.6	0.7	1.7	0.0	-1.0	0.2	1.3
High blood pressure	1.8	5.0	8.0	2.1	-1.8	2.8	2.1
Hayfever, allergic rhinitis or eczema	1.2	2.6	8.1	2.8	1.0	1.1	-0.5
Multivitamins +/- minerals	0.4	0.6	1.7	0.7	-1.3	-0.1	-0.1
Stomach or abdominal pain in last month	0.3	0.3	0.9	0.6	-0.2	-0.9	0.1
Supplements: Glucosamine	2.6	3.3	10.2	-3.2	-0.6	-1.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.3	1.1	-0.7	1.0	-0.5
Medication: Atenolol	1.6	2.0	3.1	1.4	-1.8	0.8	1.5
Medication: Levothyroxine sodium	0.7	1.2	1.7	-1.1	-1.2	-1.3	0.6
Sitting height	0.4	2.8	9.1	-0.4	-0.6	1.3	3.0
Chronic bronchitis/emphysema (father)	0.8	0.9	2.7	-1.6	-0.7	-0.8	-0.1
High blood pressure (mother)	2.0	2.8	6.4	1.4	-0.4	1.7	2.5
Body mass index (BMI)	0.5	2.0	6.2	-1.2	0.1	-2.5	0.6
Impedance of leg (left)	0.2	0.9	2.2	-0.8	-1.5	-0.7	0.4
Leg predicted mass (left)	0.3	1.8	4.9	0.1	2.2	0.7	1.3
Trunk fat mass	0.3	1.4	1.9	-1.4	0.7	-1.4	1.2
Waist circumference	0.5	1.7	5.0	-1.3	-0.3	-2.2	0.1
Number of incorrect matches in round	2.4	3.9	4.7	2.1	1.4	2.1	-2.2
Past tobacco smoking	3.3	6.1	17.6	-4.2	0.4	-2.5	0.8
Alcohol usually taken with meals	1.7	2.8	7.9	-2.8	-1.3	-1.0	-0.7
Nervous feelings	0.3	0.5	1.7	-0.3	0.5	0.4	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.5	0.6	-0.3	-0.3
Hearing difficulty/problems with background noise	0.2	0.4	0.6	-0.7	0.6	-0.4	-0.8
Hair/balding pattern: Pattern 2	1.2	1.6	4.3	-0.4	-1.1	-0.7	-2.1
Had menopause	0.9	1.1	2.1	0.9	1.2	1.4	0.1
Had other major operations	0.4	0.5	1.2	-0.6	0.4	-0.3	1.1
Forced vital capacity (FVC)	1.5	5.6	12.8	1.2	2.9	3.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.2	1.1	0.2	1.0	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.3	0.9	0.9	0.6
Qualifications: None of the above	0.1	0.2	0.5	-0.7	-0.5	-0.1	-0.2
Financial difficulties in last 2 years	0.4	0.5	1.1	-0.0	-0.9	-0.3	1.0
Mouth/teeth dental problems	1.2	1.9	5.5	0.2	1.3	2.3	-0.5
Heart attack	0.5	0.7	2.5	1.6	-0.4	-0.1	-0.2
Allergy	0.7	1.6	4.4	-2.1	-0.9	-1.0	0.4
Pain all over the body in last month	0.0	0.0	0.2	0.0	0.1	0.1	-0.4
Diabetes (self-reported)	0.4	0.7	1.0	0.7	-0.9	-0.4	1.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.0	1.7	0.0	0.0	1.5
Medication: Ramipril	0.3	0.4	1.3	-0.3	-0.3	0.5	-1.1
Medication: Simvastatin	0.8	1.2	2.2	-1.1	-1.5	-1.1	0.5
Fluid intelligence score	0.4	0.8	1.5	-1.2	-0.5	0.2	1.1
Illnesses of siblings	1.0	1.3	3.5	0.1	1.9	-0.1	-1.4
Neuroticism score	0.3	0.6	1.2	-0.1	1.1	1.1	0.0
Weight	0.3	1.4	1.9	-1.1	1.0	-1.2	1.4
Impedance of arm (right)	0.1	0.4	1.2	-0.7	-0.1	1.1	-0.2
Arm fat percentage (right)	0.6	2.5	6.2	-1.9	0.1	-2.5	0.2
Trunk fat-free mass	0.3	1.5	3.6	0.1	1.9	0.1	1.5
Hip circumference	0.2	0.7	1.2	-0.7	0.2	-1.1	1.1
Time employed in main current job	1.0	1.2	2.2	-1.5	0.1	-0.9	1.3
Alcohol intake versus 10 years previously	0.8	1.1	2.4	1.2	1.5	0.9	0.2
Father’s age at death	1.2	1.7	3.9	-2.0	-0.7	-1.4	-0.5
Worrier / anxious feelings	0.6	1.2	2.7	-1.2	0.7	0.4	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.8	0.5	0.7	0.5	1.7
Falls in the last year	0.3	0.4	1.4	0.2	1.2	0.5	-0.1
Hair/balding pattern: Pattern 3	1.1	1.6	3.3	-1.8	-1.2	-1.1	0.6
Number of live births	1.7	2.4	3.1	-1.8	-1.6	-0.9	-1.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.5	0.5	2.1	1.7	-0.1
Pulse rate	1.0	1.7	5.4	-2.3	-0.3	-1.1	-0.5
Happiness	1.0	1.2	2.8	1.7	0.0	1.2	-0.7
Noisy workplace	1.3	1.6	4.5	2.1	0.0	-0.4	-1.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.4	-1.2	0.2	-0.7	-0.0
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	7.4	-0.9	2.7	-0.6	-1.4
Mouth/teeth dental problems: Dentures	0.4	0.7	2.5	0.5	0.5	-1.6	-0.1
Asthma	0.3	0.5	1.4	1.2	0.6	0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	-0.1	-1.4	-0.5	-0.9
Medication: Cholesterol lowering	0.7	1.1	3.3	-0.9	-1.8	0.3	-0.3
Depression (self-reported)	0.6	0.7	1.3	1.1	1.0	0.6	0.5
Medication: Lansoprazole	1.9	2.2	3.5	1.9	1.2	1.3	-1.4
Prospective memory result	2.2	2.7	5.4	1.9	1.2	2.3	-0.5
Lung cancer (father)	1.1	1.3	3.2	-0.7	0.5	-1.2	-1.8
Illnesses of mother	1.6	2.0	4.6	-1.2	-0.3	-1.4	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	5.1	0.3	2.3	2.1	1.0
Pulse wave Arterial Stiffness index	2.1	2.5	6.4	-2.5	-1.1	-1.6	-0.1
Impedance of arm (left)	0.2	0.9	3.4	0.1	0.4	1.8	-0.1
Arm fat mass (right)	0.5	2.1	4.4	-1.8	0.5	-2.1	0.9
Trunk predicted mass	0.3	1.5	3.7	0.1	1.9	0.0	1.5
Standing height	0.4	4.0	6.4	0.1	2.4	2.5	1.9
Length of working week for main job	1.8	2.0	5.6	-1.5	-0.3	-2.4	0.2
Exposure to tobacco smoke at home	0.5	0.6	1.3	0.4	1.1	0.8	-0.3
Breastfed as a baby	1.0	1.3	3.0	-0.6	-1.0	-1.7	-0.9
Tense / ‘highly strung’	0.8	1.3	3.4	-0.7	1.8	1.1	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	2.9	0.7	1.7	1.6	-0.6
Hair/balding pattern: Pattern 4	0.6	1.4	3.2	-0.6	-1.3	-1.8	0.6
Birth weight of first child	1.5	2.7	4.8	-0.2	2.2	1.8	1.6
Peak expiratory flow (PEF)	0.3	0.7	2.0	-0.4	-0.3	0.6	-1.4
Pulse wave reflection index	0.2	0.3	0.7	-0.8	-0.4	-0.3	0.4
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.8	1.9	0.6	1.0	0.8
Loud music exposure frequency	0.5	0.5	2.0	0.4	0.1	0.1	1.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	-0.4	-0.2	0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	-0.6	-0.9	-1.4	-0.4
Blood clot in the leg (DVT)	0.7	0.9	3.2	-0.5	-1.8	-0.4	-0.5
Medication: Paracetamol	0.8	1.3	2.8	-0.6	1.0	-1.7	-1.1
Headache pain in last month	0.1	0.2	0.7	-0.4	-0.2	-0.8	-0.1
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.3	0.3	1.5	-1.1	-0.3
Glaucoma (self-reported)	0.8	0.9	3.4	-0.3	0.3	-1.8	0.2
Gout (self-reported)	1.3	1.7	3.3	-1.4	-1.8	-1.2	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.6	0.1	-1.0	-0.1
Medication: Amlodipine	1.0	1.4	2.1	-0.0	-1.3	1.3	1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	-0.3	0.1	-0.4	-1.1
Birth weight	1.1	2.4	4.7	2.0	2.2	0.6	-0.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	-0.7	0.2	-0.3	0.2
High blood pressure (siblings)	1.4	2.0	3.5	1.3	-1.9	1.3	0.9
Forced vital capacity (FVC), Best measure	1.6	5.9	12.8	0.8	3.0	3.6	0.9
Body fat percentage	0.5	2.1	4.8	-1.8	0.1	-2.2	0.6
Leg fat percentage (right)	1.2	4.5	12.7	-2.0	-1.1	-3.6	-0.3
Arm fat-free mass (right)	0.3	1.4	2.8	0.2	1.6	0.3	1.7
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.1	0.7	-0.6	-0.9
Comparative body size at age 10	0.1	0.2	0.6	0.4	0.2	-0.8	-0.2
Number of full brothers	0.8	1.0	2.2	1.3	-0.1	0.2	1.5
Worry too long after embarrassment	0.5	0.8	2.5	-0.7	1.6	-0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	4.5	1.4	1.4	2.1	-1.7
Wheeze or whistling in the chest in last year	0.2	0.4	1.3	0.2	1.1	-0.1	-0.2
Number of children fathered	2.2	2.5	4.8	2.2	1.8	1.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.2	0.4	0.4	0.9
Age at first live birth	0.3	0.5	1.0	1.0	1.0	-0.1	-0.4
Pulse wave peak to peak time	2.4	2.8	6.8	2.6	1.2	1.7	0.2
Health satisfaction	1.4	1.8	2.9	1.3	-0.1	1.7	1.7
Shortness of breath walking on level ground	0.1	0.2	0.7	0.8	0.0	-0.1	0.1
Qualifications: College or University degree	0.2	0.6	1.5	-1.2	0.3	-1.0	0.1
Eye problems/disorders: None of the above	3.1	3.5	8.0	0.4	2.4	2.8	0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.4	0.4	-1.6	-0.4	0.8
Emphysema/chronic bronchitis	0.3	0.3	0.7	0.5	0.9	0.2	-0.5
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	-0.6	0.3	0.7	1.3
Neck or shoulder pain in last month	1.0	1.4	3.6	1.4	1.9	-0.0	-0.1
Medication: Blood pressure	0.7	1.2	3.4	-0.1	-1.8	1.1	-0.4
Angina (self-reported)	1.3	1.7	5.8	2.4	0.5	1.0	-0.2
Migraine (self-reported)	0.5	0.7	1.6	1.0	-0.4	1.3	-0.2
Medication: Ibuprofen	0.4	0.5	1.7	-0.2	-0.4	-0.1	-1.3
Medication: Allopurinol	1.0	1.4	3.4	-1.1	-0.9	-0.4	1.8
Medication: Omeprazole	1.6	1.9	3.0	-1.3	-1.7	-1.4	1.1
Medication: Seretide 50 evohaler	0.4	0.4	1.6	-1.3	-0.4	0.1	0.2
Mean time to correctly identify matches	1.3	2.5	4.1	2.0	1.5	1.4	-1.2
Heart disease (mother)	2.2	2.7	5.3	2.3	-0.8	1.2	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.8	-0.6	-1.3	-0.7	-1.3
Whole body fat mass	0.4	1.6	2.6	-1.5	0.6	-1.6	1.2
Leg fat mass (right)	0.6	2.2	6.5	-1.5	-0.2	-2.5	0.3
Arm predicted mass (right)	0.3	1.4	3.2	0.2	1.5	0.0	1.8
Pulse rate, automated reading	1.3	4.2	12.7	-3.6	-1.8	-1.0	0.1
Alcohol intake frequency.	0.4	0.9	2.0	-1.0	0.7	0.1	-1.4
Comparative height size at age 10	0.0	0.2	0.3	-0.6	0.4	0.5	0.3
Number of full sisters	1.5	1.8	3.4	-1.3	-0.4	-1.4	-1.8
Suffer from ‘nerves’	0.2	0.4	0.9	0.2	0.6	1.0	-0.3
Overall health rating	0.2	0.4	0.7	0.8	0.5	0.5	0.6
Chest pain or discomfort	2.0	2.9	7.3	-1.4	-1.4	-2.7	-0.6
Had major operations	1.2	1.4	2.3	0.6	1.5	1.0	-1.4
Age at last live birth	0.3	0.5	1.3	-0.3	0.7	-0.0	-1.1
Family relationship satisfaction	0.2	0.2	0.4	-0.6	-0.7	-0.0	-0.3
Leg pain on walking	1.4	1.7	2.3	-1.4	-0.8	-1.5	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.7	-0.2	-0.4	-1.9	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	-1.3	-1.1	-0.2	-0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	-0.3	-0.4	-0.1	-1.0
Medication: Aspirin	0.3	0.4	0.9	0.2	-1.0	-0.6	-0.4
Supplements: Vitamin C	1.2	1.5	2.5	-1.6	-1.1	-1.3	0.7
Knee pain experienced in last month	0.4	0.7	1.1	-1.0	1.1	-0.8	-0.1
Hypertension (Self-reported)	1.4	3.8	4.6	1.5	-2.0	2.1	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.4	-0.2	-1.3	-0.8	1.5
Illnesses of father: Heart disease	2.8	3.9	7.6	-1.7	-1.8	-2.8	1.3
Illnesses of siblings: Diabetes	0.4	0.5	0.6	-0.8	0.6	-0.7	0.6
Smoking status: Previous	3.9	5.9	16.0	4.0	0.7	2.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.9	0.4	2.4	0.7	0.6
Whole body fat-free mass	0.3	1.8	4.6	0.1	2.1	0.4	1.6
Leg fat-free mass (right)	0.5	2.6	5.6	0.3	2.4	1.3	1.7
Arm fat percentage (left)	0.4	1.6	3.9	-1.5	0.5	-2.0	0.3
Average weekly red wine intake	2.9	4.3	8.4	-1.8	-2.1	-2.9	1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.8	0.9	1.2	0.1	-1.4
Mood swings	0.3	0.5	1.3	0.5	0.7	1.1	0.3
Loneliness, isolation	0.3	0.4	0.6	0.6	0.5	0.8	-0.4
Long-standing illness, disability or infirmity	0.9	1.4	2.0	0.9	0.9	1.4	-1.4
Ever had bowel cancer screening	1.5	1.7	5.5	-1.0	0.6	-0.2	-2.4
Diabetes diagnosed by doctor	0.4	0.7	1.4	0.1	-1.2	-1.0	0.6
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	8.5	0.1	0.6	0.3	2.9
Friendships satisfaction	1.1	1.3	3.0	1.1	0.3	1.0	1.7
Qualifications: nursing, teaching	0.4	0.6	1.2	-1.1	0.5	0.9	-0.2
Commuting to job workplace: Walk	1.1	1.2	2.4	1.6	1.0	1.1	0.6
Eye problems/disorders: Cataract	1.0	1.1	2.3	0.0	-1.5	-1.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.3	-0.6	-0.7	0.3
Medication for cholesterol	1.8	2.7	5.0	-1.5	1.3	-2.2	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.0	-0.1	0.3	0.2	-1.4
Back pain experienced in last month	0.9	1.4	3.2	0.8	0.9	1.8	0.9
Mineral and other dietary supplements	2.3	3.1	6.0	2.4	1.3	1.9	1.1
Breast cancer (self-reported)	1.5	1.8	3.4	1.4	-0.0	1.8	1.4
Asthma (self-reported)	0.3	0.6	1.7	1.3	0.7	0.5	-0.0
Osteoporosis (self-reported)	0.4	0.5	0.8	0.8	-0.7	-0.9	-0.5
Osteoarthritis (self-reported)	0.6	0.8	1.7	0.5	1.3	1.1	-0.2
Medication: Aspirin	0.2	0.3	0.7	0.5	-0.8	0.0	-0.4
Medication: Gliclazide	0.8	1.0	2.1	-0.8	-0.7	-0.8	1.4
Illnesses of father: None of the above (group 1)	2.1	2.6	7.3	0.6	1.4	0.9	-2.7
Smoking status: Current	0.4	0.6	1.2	1.1	0.2	1.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-1.0	1.1	0.1	0.1
Whole body water mass	0.3	1.8	4.5	0.0	2.1	0.4	1.6
Leg predicted mass (right)	0.5	2.7	5.9	0.3	2.4	1.3	1.8
Arm fat mass (left)	0.5	1.9	3.9	-1.5	0.5	-2.0	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	1.7	1.2	0.9	1.3	0.2
Average weekly champagne plus white wine intake	0.9	1.2	2.7	-1.6	0.1	-1.1	0.9
Miserableness	0.4	0.7	1.0	-0.9	-0.3	-0.9	1.0
Guilty feelings	0.9	1.3	3.7	1.2	0.1	-0.2	1.9
Wears glasses or contact lenses	0.3	0.4	1.1	0.3	-1.1	0.4	0.4
Ever taken oral contraceptive pill	2.8	3.2	6.7	-0.7	-2.6	-1.9	1.3
Hearing aid user	0.3	0.4	0.6	-0.5	0.6	-0.8	-0.5
Mother’s age at death	0.9	1.1	2.8	0.1	1.7	1.0	-0.9
Financial situation satisfaction	0.6	0.8	2.8	-0.3	-0.1	-0.6	1.7
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.8	2.4	0.5	1.3	0.7
Commuting to job workplace: Public transport	1.4	1.6	3.1	1.7	0.6	1.8	-0.5
Eye problems/disorders: Glaucoma	2.2	2.6	8.3	-1.0	-0.9	-2.9	0.4
Medication: Blood pressure	0.9	1.8	2.7	1.6	-1.3	1.6	0.3
Pain type(s) experienced in last month: Hip pain	1.2	1.6	2.9	0.5	1.1	1.7	-1.4
Supplements: Fish oil (including cod liver oil)	3.4	4.5	7.0	-2.6	-2.0	-2.5	-0.8
High cholesterol (Self-reported)	0.5	0.8	3.0	-0.4	-1.7	-0.0	0.5
Medication: Bendroflumethiazide	0.8	1.2	1.5	1.2	-1.2	1.2	-0.6
Medication: Paracetamol	1.0	1.5	2.3	0.0	1.4	-1.3	-1.5
Medication: Lisinopril	1.1	1.4	4.9	0.9	-2.2	-0.1	0.0
Medication: Atorvastatin	0.5	0.6	2.3	-0.1	-1.5	0.6	0.0
Illnesses of father: High blood pressure	2.6	3.2	6.0	1.8	0.4	2.4	1.9
Alcohol drinker status: Never	0.3	0.3	0.6	-0.4	-0.8	0.2	0.7
Ever smoked	1.7	3.0	8.2	2.9	-1.2	1.0	-1.1
Basal metabolic rate	0.3	1.6	3.3	-0.3	1.8	-0.1	1.7
Leg fat percentage (left)	1.0	3.7	10.3	-2.1	-0.7	-3.2	0.1
Arm fat-free mass (left)	0.2	1.2	3.1	-0.7	0.8	-0.6	1.8
Number of operations (self-reported)	0.9	1.3	3.2	-1.2	1.8	-0.3	-0.8
Average weekly beer plus cider intake	1.0	1.4	2.2	1.3	0.1	1.5	1.3
Irritability	0.4	0.6	2.4	0.3	-0.0	1.6	0.3
Risk taking	0.6	0.9	1.3	-0.7	0.7	-1.1	1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.1	-1.4	-0.0	0.9	0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.0	-0.2	-0.7	-1.4	1.3
Age started oral contraceptive pill	0.3	0.4	1.2	-0.1	-0.1	0.4	-1.1
Diastolic blood pressure, automated reading	2.0	6.3	13.1	-0.8	-3.6	0.6	3.3
Ever depressed for a whole week	2.7	3.3	4.9	2.2	1.9	2.1	0.2
Unable to work because of sickness or disability	1.0	1.3	2.1	0.3	1.4	1.2	-1.2
Commuting to job workplace: Cycle	1.2	1.5	2.1	-1.4	-1.4	-1.4	0.1
Myopia	1.1	1.6	3.2	0.9	1.3	1.8	0.7
Vascular/heart problems diagnosed by doctor	1.3	3.6	4.6	-1.9	1.7	-2.1	-1.8
Cholesterol lowering medication	0.8	1.1	2.5	-0.9	-1.6	0.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	-0.6	-1.7	-0.8	0.7
Pain experienced in last month	0.5	0.9	2.2	-0.9	-1.5	-0.3	-0.6
Supplements: Calcium	0.2	0.2	0.6	-0.5	-0.1	-0.8	-0.2
Basal cell carcinoma (self-reported)	0.7	0.9	2.3	1.0	1.5	0.3	-0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.2	1.5	-0.7	-0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.8	-0.7	-1.3	-0.5	-0.8
Heart disease (siblings)	0.5	0.6	1.0	-0.7	-1.0	-0.0	0.8
Alcohol drinker status: Previous	1.9	2.2	4.1	0.8	1.8	0.9	-2.0
Pack years of smoking	0.5	0.7	1.1	-0.9	0.8	-1.1	-0.6
Impedance of whole body	0.1	0.4	0.8	-0.6	-0.9	0.7	0.0
Leg fat mass (left)	0.5	2.1	5.8	-1.6	0.1	-2.4	0.6
Arm predicted mass (left)	0.2	1.2	3.0	-0.4	1.2	-0.6	1.7