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chr20:56,335,290-58,312,294

Best TWAS P=1.54e-118 · Best GWAS P=1.73e-108 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CTSZ	0.06	0.03	lasso	3	0.04	3.2e-05	-13.6	12.8	1.1e-37	0.48	0.97	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLMO2	0.08	0.02	bslmm	576	0.02	1.3e-03	19.1	-17.6	2.0e-69	-0.82	0.02	0.97	FALSE
3	GTEx	Adipose Subcutaneous	NELFCD	0.43	0.31	enet	36	0.38	3.3e-33	18.5	-19.0	3.7e-80	-0.79	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	NELFCD	0.29	0.20	lasso	3	0.23	2.8e-12	17.2	-19.4	1.1e-83	-0.91	0.38	0.62	FALSE
5	GTEx	Artery Aorta	NELFCD	0.43	0.34	lasso	4	0.37	1.8e-21	18.5	-19.3	6.1e-83	-0.83	1.00	0.00	FALSE
6	GTEx	Artery Coronary	NELFCD	0.36	0.20	lasso	7	0.22	6.5e-08	17.2	-19.3	1.3e-82	-0.90	0.03	0.96	FALSE
7	GTEx	Artery Tibial	NELFCD	0.24	0.16	lasso	4	0.16	1.2e-12	18.5	-20.0	1.5e-88	-0.77	0.97	0.03	FALSE
8	GTEx	Artery Tibial	STX16-NPEPL1	0.17	0.01	enet	10	0.04	8.5e-04	-5.8	6.0	1.9e-09	0.03	0.39	0.03	TRUE
9	GTEx	Breast Mammary Tissue	NELFCD	0.40	0.20	lasso	7	0.19	4.1e-10	18.5	-18.9	1.8e-79	-0.75	0.82	0.18	FALSE
10	GTEx	Breast Mammary Tissue (Male)	NELFCD	0.05	-0.01	lasso	1	-0.01	7.8e-01	18.5	-18.5	9.9e-77	-0.73	0.04	0.19	FALSE
11	GTEx	Breast Mammary Tissue (Female)	NELFCD	0.35	0.16	lasso	7	0.09	1.1e-03	18.5	-19.2	5.9e-82	-0.78	0.03	0.83	TRUE
12	GTEx	Cells Transformed fibroblasts	NELFCD	0.47	0.29	lasso	8	0.35	2.8e-27	16.0	-20.5	1.3e-93	-0.86	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	SLMO2	0.16	0.13	lasso	1	0.11	8.3e-09	-11.0	11.0	6.0e-28	0.42	0.97	0.03	FALSE
14	GTEx	Cells Transformed fibroblasts	NPEPL1	0.15	0.12	lasso	2	0.15	2.1e-11	4.7	-5.6	2.3e-08	-0.02	1.00	0.00	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	NELFCD	0.45	0.14	lasso	9	0.18	3.4e-07	21.6	-23.0	1.5e-117	-0.90	0.01	0.99	TRUE
16	GTEx	Esophagus Mucosa	NELFCD	0.32	0.20	enet	8	0.27	2.1e-18	17.2	-19.0	7.7e-81	-0.88	0.68	0.32	TRUE
17	GTEx	Esophagus Mucosa	STX16-NPEPL1	0.13	0.05	lasso	5	0.03	2.8e-03	4.6	5.5	4.5e-08	0.01	0.39	0.02	FALSE
18	GTEx	Esophagus Muscularis	NELFCD	0.23	0.15	enet	14	0.18	6.7e-11	18.5	-19.4	7.0e-84	-0.87	0.40	0.60	FALSE
19	GTEx	Heart Atrial Appendage	NELFCD	0.23	0.17	enet	23	0.19	4.5e-09	14.5	-17.6	3.2e-69	-0.72	0.17	0.80	FALSE
20	GTEx	Lung	NELFCD	0.22	0.22	lasso	2	0.21	5.0e-16	18.5	-19.7	1.2e-86	-0.83	1.00	0.00	FALSE
21	GTEx	Lung	STX16-NPEPL1	0.15	0.07	lasso	4	0.09	3.6e-07	-5.6	6.1	1.3e-09	0.00	0.88	0.00	TRUE
22	GTEx	Muscle Skeletal	NELFCD	0.30	0.22	enet	17	0.26	3.5e-25	18.5	-20.7	5.8e-95	-0.72	1.00	0.00	FALSE
23	GTEx	Muscle Skeletal	CTSZ	0.09	0.01	enet	10	0.07	3.3e-07	-5.5	-5.1	2.9e-07	-0.13	0.89	0.00	FALSE
24	GTEx	Nerve Tibial	NELFCD	0.30	0.17	enet	25	0.23	2.8e-16	18.5	-18.2	8.9e-74	-0.84	0.05	0.95	FALSE
25	GTEx	Nerve Tibial	NPEPL1	0.20	0.06	lasso	6	0.11	4.7e-08	5.1	-5.9	3.1e-09	-0.02	0.96	0.00	FALSE
26	GTEx	Pancreas	NELFCD	0.17	0.03	lasso	3	0.07	5.7e-04	18.5	-19.8	2.6e-87	-0.88	0.08	0.84	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	NELFCD	0.22	0.15	lasso	3	0.11	1.9e-06	18.5	-18.0	1.4e-72	-0.72	0.75	0.24	FALSE
28	GTEx	Skin Sun Exposed Lower leg	NELFCD	0.28	0.21	lasso	7	0.22	1.1e-17	18.5	-19.4	6.9e-84	-0.84	0.98	0.02	FALSE
29	GTEx	Skin Sun Exposed Lower leg	NPEPL1	0.16	0.07	lasso	2	0.11	4.4e-09	-5.6	-6.0	2.7e-09	-0.02	1.00	0.00	FALSE
30	GTEx	Skin Sun Exposed Lower leg	STX16-NPEPL1	0.14	0.10	enet	7	0.12	8.7e-10	-5.8	5.5	3.2e-08	0.01	1.00	0.00	FALSE
31	GTEx	Spleen	NELFCD	0.51	0.31	lasso	7	0.18	2.9e-05	18.5	-18.2	1.1e-73	-0.74	0.15	0.73	FALSE
32	GTEx	Testis	NELFCD	0.53	0.51	lasso	3	0.51	4.2e-26	-14.1	-16.4	2.6e-60	-0.28	1.00	0.00	FALSE
33	GTEx	Testis	NPEPL1	0.19	0.06	enet	6	0.09	8.5e-05	5.4	-5.6	2.3e-08	-0.02	0.53	0.04	FALSE
34	GTEx	Thyroid	NPEPL1	0.16	0.00	enet	38	0.02	1.0e-02	-1.6	-5.8	4.8e-09	-0.09	0.07	0.05	TRUE
35	GTEx	Thyroid	STX16-NPEPL1	0.20	0.11	lasso	5	0.08	4.7e-07	-5.1	5.4	7.1e-08	0.05	0.97	0.00	FALSE
36	GTEx	Uterus	NELFCD	0.58	0.07	lasso	10	0.06	2.4e-02	18.5	-19.6	1.4e-85	-0.65	0.04	0.48	FALSE
37	GTEx	Vagina	NELFCD	0.65	0.12	enet	74	0.07	1.3e-02	21.6	-9.0	3.0e-19	-0.40	0.01	0.91	FALSE
38	GTEx	Whole Blood	RP11-261P9.4	0.09	0.02	lasso	3	0.02	1.0e-02	5.4	5.3	1.2e-07	0.03	0.38	0.02	FALSE
39	METSIM	Adipose	APCDD1L	0.05	0.00	blup	607	0.01	1.7e-02	2.6	7.9	3.3e-15	0.16	0.16	0.06	TRUE
40	METSIM	Adipose	NELFCD	0.25	0.21	bslmm	540	0.23	1.0e-33	18.5	-19.2	1.9e-82	-0.74	1.00	0.00	FALSE
41	NTR	Blood	TH1L	0.07	0.03	bslmm	553	0.05	4.8e-16	-3.7	-14.2	1.7e-45	-0.34	1.00	0.00	TRUE
42	ROSMAP	Brain Pre-frontal Cortex	NELFCD	0.24	0.12	bslmm	551	0.16	5.4e-20	18.5	-19.9	9.5e-88	-0.73	1.00	0.00	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	STX16	0.15	0.12	lasso	7	0.12	6.4e-15	5.1	5.4	8.5e-08	0.06	1.00	0.00	FALSE
44	YFS	Blood	CTSZ	0.09	0.07	bslmm	517	0.09	4.5e-28	-1.0	10.0	1.3e-23	0.16	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TH1L	0.05	0.04	lasso	3	0.02	5.4e-03	-14.0	-16.9	7.2e-64	-0.33	0.04	0.15	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSZ	0.01	0.02	lasso	3	0.01	5.2e-04	-13.6	-13.4	9.7e-41	-0.44	0.15	0.14	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	TH1L	0.04	0.01	enet	10	0.03	3.7e-07	17.2	-20.4	1.6e-92	-0.72	0.01	0.98	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SLMO2	0.06	0.04	blup	51	0.03	8.8e-03	-13.6	6.1	1.4e-09	0.23	0.05	0.06	TRUE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TH1L	0.18	0.02	blup	46	0.04	2.9e-03	17.2	-23.1	1.5e-118	-0.74	0.01	0.23	TRUE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	NPEPL1	0.07	0.00	blup	56	0.04	3.3e-03	5.4	-5.8	6.1e-09	-0.02	0.01	0.72	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	TH1L	0.08	0.05	lasso	3	0.07	8.1e-05	17.2	-17.8	8.5e-71	-0.88	0.02	0.93	FALSE
52	The Cancer Genome Atlas	Esophageal Carcinoma	TH1L	0.19	0.16	blup	46	0.19	8.9e-07	14.5	-21.6	2.3e-103	-0.87	0.01	0.98	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NPEPL1	0.06	0.08	lasso	2	0.07	3.9e-08	5.4	-5.5	4.2e-08	-0.01	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TH1L	0.10	0.06	blup	46	0.08	3.3e-09	22.1	-20.8	4.6e-96	-0.80	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPEPL1	0.04	0.03	lasso	4	0.03	1.2e-04	-5.6	-5.7	1.2e-08	-0.04	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TH1L	0.12	0.06	enet	11	0.12	7.1e-14	21.5	-20.1	2.7e-90	-0.79	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLMO2	0.04	0.02	blup	51	0.02	1.6e-02	-3.5	-12.2	3.9e-34	-0.61	0.03	0.22	FALSE
58	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TH1L	0.14	0.06	blup	46	0.11	5.4e-07	18.5	-22.5	9.8e-112	-0.79	0.02	0.94	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSZ	0.04	0.01	blup	50	0.01	1.7e-02	9.5	-15.2	6.5e-52	-0.70	0.03	0.81	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	TH1L	0.12	0.02	enet	20	0.06	3.6e-07	21.5	-15.0	7.1e-51	-0.60	0.01	0.97	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	SLMO2	0.03	0.00	blup	52	0.01	3.0e-02	-11.0	16.7	2.1e-62	0.65	0.07	0.19	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TH1L	0.12	0.07	blup	46	0.11	2.2e-12	17.2	-21.9	4.9e-106	-0.82	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TH1L	0.07	0.00	blup	46	0.02	2.8e-02	18.5	-19.8	2.5e-87	-0.79	0.02	0.56	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TH1L	0.16	0.00	enet	14	0.08	3.4e-04	21.6	-20.1	1.3e-89	-0.69	0.01	0.68	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	TH1L	0.32	0.12	blup	47	0.27	1.8e-28	-14.1	-22.3	7.4e-110	-0.64	0.99	0.01	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	TUBB1	0.51	0.06	enet	16	0.12	5.2e-13	19.1	-11.2	3.3e-29	-0.60	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TH1L	0.20	0.03	blup	47	0.04	2.4e-02	22.1	-21.6	1.4e-103	-0.83	0.00	0.75	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	TH1L	0.05	0.04	lasso	2	0.03	1.9e-03	18.5	-19.9	3.2e-88	-0.87	0.05	0.81	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	TH1L	0.21	0.08	blup	46	0.11	5.4e-11	-14.1	-21.9	1.4e-106	-0.61	0.86	0.14	TRUE
70	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSZ	0.14	0.04	blup	49	0.08	2.7e-03	21.6	-20.1	1.0e-89	-0.91	0.01	0.82	FALSE
71	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TUBB1	0.13	0.06	blup	50	0.04	2.3e-02	4.5	-16.7	2.6e-62	-0.83	0.01	0.60	FALSE