TWAS hub - WFDC13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.0580	0.0460	5.0e-03	0.048	0.021	0.038	NA	0.036	0.00095	0.02200	0.00270	NA	0.0034
2	TCGA	Lung Adenocarcinoma	0.0644	0.0445	6.3e-05	0.018	0.023	0.029	NA	0.032	0.00280	0.00099	0.00021	NA	0.0001
3	TCGA	Stomach Adenocarcinoma	0.0320	0.0230	7.5e-03	0.030	0.011	0.015	NA	0.017	0.00300	0.04900	0.02800	NA	0.0200

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication for cholesterol	10.4	15.8	18.3	-3.9	-4.3	-3.7
Cholesterol lowering medication	9.5	13.9	17.7	4.2	3.6	3.3
Reaction Time	7.5	14.2	15.1	-3.6	-3.8	-3.9
Neuroticism (2016)	7.2	10.3	13.0	3.6	2.8	3.1
Medication for hormone replacement therapy	7.2	8.0	9.4	2.7	3.1	2.7
Allergy or Eczema	6.3	16.5	18.6	-3.6	-4.2	-4.3
Cardiovascular Disease	6.0	19.8	21.7	4.7	4.5	4.2
High cholesterol (Self-reported)	6.0	10.7	13.0	3.6	3.4	2.8
Medication: Simvastatin	5.8	8.5	10.8	3.3	2.7	2.8
Hayfever, allergic rhinitis or eczema	5.2	11.2	13.2	-2.9	-3.6	-3.4
Hypertension (Self-reported)	4.7	13.2	14.0	3.7	3.6	3.5
Frequency of unenthusiasm / disinterest in last 2 weeks	4.6	6.2	8.6	2.9	2.4	2.1
Alcohol drinker status: Never	4.6	5.5	6.8	2.3	2.1	2.6
Overall health rating	4.5	9.6	11.1	3.3	3.0	2.9
Frequency of tenseness / restlessness in last 2 weeks	4.4	6.9	7.9	2.8	2.5	2.5
Crohns Disease (2012)	4.2	6.8	8.2	-2.9	-2.8	-2.1
Health satisfaction	4.2	5.4	7.0	2.6	2.2	2.1
Mean time to correctly identify matches	4.2	8.0	9.0	-2.6	-2.9	-3.0
Medication: Blood pressure	4.2	8.0	10.4	2.7	3.2	2.5
High blood pressure	4.0	11.2	11.8	3.4	3.4	3.2
Leg pain on walking	4.0	5.0	6.6	2.2	2.6	1.9
Knee pain experienced in last month	4.0	6.2	8.2	2.9	2.6	2.0
Vascular/heart problems diagnosed by doctor	3.8	10.4	13.2	-3.6	-3.2	-2.8
Financial difficulties in last 2 years	3.6	4.8	7.2	2.7	2.1	1.6
Qualifications: A levels/AS levels or equivalent	3.6	7.9	8.7	-2.9	-2.9	-2.6
Number of self-reported non-cancer illnesses	3.5	6.0	8.9	3.0	2.0	2.3
Qualifications: College or University degree	3.4	10.7	12.4	-3.2	-3.1	-3.5
Medication for cholesterol, blood pressure or diabetes	3.3	5.4	5.8	-2.4	-2.2	-2.4
Crohns Disease (2017)	3.2	7.1	7.3	-2.6	-2.7	-2.7
Triglycerides	3.2	5.3	7.7	2.2	1.8	2.8
Medication: Metformin	3.2	4.4	6.0	1.4	2.4	2.3
Breast cancer (self-reported)	3.2	3.8	5.3	2.3	1.8	1.7
Average weekly fortified wine intake	3.1	3.6	4.0	1.9	1.8	2.0
Prostate Cancer	3.0	4.2	4.9	-2.2	-2.0	-1.9
Other serious medical condition/disability diagnosed by doctor	3.0	3.8	6.7	2.6	1.4	1.6
Medication: Cholesterol lowering	3.0	4.7	5.1	2.2	2.0	2.3
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.5	4.0	2.0	1.9	1.7
Medication: Co-codamol	2.9	3.4	3.8	1.9	1.8	1.8
Qualifications: CSEs or equivalent	2.9	3.8	5.2	2.3	2.0	1.5
Medication: Gliclazide	2.9	3.2	4.8	1.5	2.2	1.6
Forced vital capacity (FVC), Best measure	2.8	10.2	12.8	-3.3	-2.6	-3.6
Blood Platelet Count	2.7	31.6	39.4	5.7	6.3	4.8
Blood White Count	2.7	19.9	21.2	4.4	4.3	4.6
Worrier / anxious feelings	2.6	4.9	6.2	2.5	2.0	2.1
Loneliness, isolation	2.5	3.4	3.7	1.7	1.9	1.9
Ever had prostate specific antigen (PSA) test	2.5	2.9	3.5	1.3	1.9	1.9
Breast Cancer	2.4	5.9	7.4	2.4	2.7	2.2
Back pain experienced in last month	2.4	3.5	4.2	1.8	2.0	1.8
Heart disease (mother)	2.3	2.9	3.2	-1.8	-1.7	-1.6
Pulse rate, automated reading	2.3	7.5	8.7	3.0	2.8	2.4
Mother’s age at death	2.3	2.9	3.2	-1.8	-1.7	-1.6
Allergy	2.2	5.0	6.2	2.0	2.2	2.5
Commuting to job workplace: Walk	2.2	2.4	3.0	-1.5	-1.4	-1.7
Heart disease (siblings)	2.2	2.7	3.3	1.8	1.4	1.7
Lung FEV1/FVC ratio	2.1	10.6	11.9	3.5	3.1	3.2
Medication: Ramipril	2.1	2.7	3.1	1.6	1.5	1.8
Noisy workplace	2.1	2.6	2.7	1.6	1.6	1.6
Medication: Amlodipine	2.1	2.9	4.9	2.2	1.2	1.6
Body Mass Index (BMI) (2010)	2.0	2.7	3.7	-1.1	-1.8	-1.9
Hearing difficulty/problems: Yes	2.0	3.1	4.1	-1.7	-2.0	-1.4
Diabetes (self-reported)	2.0	3.1	4.5	1.2	1.8	2.1
Illnesses of siblings	2.0	2.8	3.6	-1.9	-1.6	-1.6
Medication: Blood pressure	2.0	3.5	4.5	2.1	1.4	2.0
Chest pain or discomfort	2.0	2.9	4.1	1.7	2.0	1.3
Illnesses of father: High blood pressure	2.0	2.4	3.8	1.2	1.4	2.0
Basal cell carcinoma (self-reported)	2.0	2.4	3.4	1.5	1.8	1.2
Age when periods started (menarche)	1.9	4.6	5.3	-1.8	-2.3	-2.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	3.0	1.7	1.7	1.3
Average weekly red wine intake	1.9	2.8	3.4	-1.3	-1.8	-1.8
Fractured/broken bones in last 5 years	1.9	2.5	2.8	-1.5	-1.6	-1.7
Alzheimer’s Disease (in mother)	1.8	2.1	3.6	1.9	1.2	1.1
Ever used hormone-replacement therapy (HRT)	1.8	2.3	2.5	1.4	1.6	1.6
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	3.9	-2.0	-1.8	-1.2
Shortness of breath walking on level ground	1.8	2.2	2.4	1.5	1.5	1.4
Mood swings	1.8	3.2	4.9	2.2	1.6	1.4
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.5	1.0	1.9	1.5
Systolic Blood Pressure	1.7	8.7	12.8	3.6	2.7	2.5
Current tobacco smoking	1.7	2.7	2.9	1.6	1.7	1.7
Father’s age at death	1.7	2.2	3.3	-1.4	-1.8	-1.2
Number of children fathered	1.7	1.9	2.3	1.3	1.2	1.5
Smoking status: Previous	1.7	2.6	3.6	-1.2	-1.6	-1.9
Smoking status: Current	1.7	2.7	3.2	1.6	1.8	1.5
Number of live births	1.6	2.3	3.0	1.3	1.5	1.7
Pulse wave reflection index	1.6	2.0	3.2	-1.2	-1.1	-1.8
Illnesses of father: Heart disease	1.6	2.3	3.0	1.7	1.4	1.4
Medication: Lisinopril	1.6	2.1	2.8	1.4	1.7	1.3
Neuroticism	1.5	3.6	4.5	1.7	1.8	2.1
Exposure to tobacco smoke at home	1.5	1.6	2.3	1.5	1.0	1.3
Supplements: Vitamin C	1.5	1.7	2.2	-1.5	-1.3	-1.2
HDL Cholesterol	1.4	2.3	2.7	-1.5	-1.5	-1.7
Rheumatoid Arthritis	1.4	1.9	2.5	1.0	1.6	1.5
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	4.1	-2.0	-1.0	-0.3
Commuting to job workplace: Public transport	1.4	1.6	2.5	-1.2	-1.6	-1.0
Unable to work because of sickness or disability	1.4	1.8	3.0	1.7	0.8	1.3
Waist Hip Ratio (WHR)	1.3	6.0	8.3	2.9	2.3	2.0
Sensitivity / hurt feelings	1.3	2.2	2.5	1.3	1.6	1.5
Medication: Atenolol	1.3	1.7	2.3	1.2	1.1	1.5
Age at first live birth	1.3	2.4	3.4	-1.0	-1.9	-1.7
Alcohol intake frequency.	1.3	3.1	3.9	1.8	2.0	1.6
Family relationship satisfaction	1.3	1.6	1.9	1.4	1.1	1.3
Lung FVC	1.2	6.0	7.3	-2.5	-2.1	-2.7
Ever had hysterectomy (womb removed)	1.2	1.4	3.1	1.7	0.8	0.7
Diabetes (father)	1.2	1.5	2.1	1.4	1.3	0.8
Forced vital capacity (FVC)	1.2	4.5	6.1	-2.2	-1.6	-2.5
Impedance of arm (right)	1.2	5.4	7.1	-2.7	-2.3	-2.0
Breastfed as a baby	1.2	1.5	2.3	-0.6	-1.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	3.1	-1.3	-1.8	-1.6
Mineral and other dietary supplements	1.2	1.6	2.3	-1.1	-1.1	-1.5
Tinnitus: Yes, now most or all of the time	1.2	1.5	2.1	-1.1	-1.0	-1.5
Maternal smoking around birth	1.1	1.5	1.7	1.1	1.3	1.3
Supplements: Glucosamine	1.1	1.5	1.6	1.1	1.3	1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	1.9	1.4	1.0	1.0
Heart attack	1.1	1.4	2.9	1.7	0.8	0.9
Osteoporosis (self-reported)	1.1	1.3	2.2	-1.5	-1.1	-0.8
Miserableness	1.1	1.9	2.1	1.4	1.4	1.4
Financial situation satisfaction	1.1	1.4	2.6	1.6	0.9	0.9
Mean Putamen Volume	1.0	1.1	1.7	0.9	0.9	1.3
Fasting Glucose	1.0	1.2	2.0	1.1	0.8	1.4
Body mass index (BMI)	1.0	4.1	5.2	2.3	2.1	1.6
Past tobacco smoking	1.0	1.9	3.1	0.8	1.4	1.7
Hearing difficulty/problems with background noise	1.0	1.5	2.2	-1.1	-1.5	-1.1
Neuroticism score	1.0	2.1	2.6	1.3	1.4	1.6
Impedance of arm (left)	1.0	4.5	5.8	-2.4	-2.2	-1.7
Glaucoma (self-reported)	1.0	1.2	1.7	0.9	0.9	1.3
Worry too long after embarrassment	1.0	1.7	1.7	-1.3	-1.3	-1.3
Long-standing illness, disability or infirmity	1.0	1.5	2.1	1.4	1.1	1.1
Ever taken oral contraceptive pill	1.0	1.1	1.8	-1.1	-0.7	-1.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.5	1.6	0.7	0.9
Blood Red Count	0.9	8.3	11.4	-2.5	-2.8	-3.4
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.6	0.6	1.4	1.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.8	1.7	0.7	0.6
Waist circumference	0.9	3.4	4.9	2.2	1.8	1.4
Qualifications: None of the above	0.9	2.0	2.5	1.1	1.5	1.6
Depression (self-reported)	0.9	1.1	1.4	0.9	0.9	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.3	1.5	1.1	0.9
Qualifications: nursing, teaching	0.9	1.4	1.9	-1.1	-1.4	-1.0
Age started oral contraceptive pill	0.9	1.1	1.7	1.0	1.3	0.8
Neuroticism (Nagel 2018)	0.8	1.9	2.0	1.3	1.4	1.4
Primary Biliary Cirrhosis	0.8	1.1	1.3	-1.0	-1.0	-1.2
Heel T-Score	0.8	6.2	6.9	2.6	2.3	2.5
Number of treatments/medications taken	0.8	1.3	2.3	1.5	0.9	1.0
High blood pressure (mother)	0.8	1.1	2.2	-0.5	-1.0	-1.5
Pulse rate	0.8	1.4	2.1	1.4	0.9	1.1
Happiness	0.8	0.9	1.4	1.2	1.1	0.5
Diabetes diagnosed by doctor	0.8	1.2	2.2	0.6	1.1	1.5
Illnesses of father: None of the above (group 1)	0.8	0.9	1.7	-1.3	-0.9	-0.5
Eye problems/disorders: Glaucoma	0.8	1.0	1.9	0.6	0.8	1.4
Ever depressed for a whole week	0.8	1.0	1.4	1.2	1.2	0.6
Depressed Affect (Nagel 2018)	0.7	1.5	1.6	1.3	1.1	1.2
Serious illness, injury or assault to yourself	0.7	0.8	1.9	1.4	0.8	0.2
Fluid intelligence score	0.7	1.4	2.1	-0.8	-1.2	-1.5
Pulse wave Arterial Stiffness index	0.7	0.8	0.9	-0.7	-1.0	-1.0
Hair/balding pattern: Pattern 4	0.7	1.6	2.0	1.1	1.4	1.3
Medication: Ibuprofen	0.7	0.9	1.6	-0.5	-1.3	-0.8
Age at last live birth	0.7	1.0	2.1	-0.1	-1.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	2.0	-1.4	-1.1	-1.2
Guilty feelings	0.7	1.0	1.9	1.4	0.9	0.6
Medication: Bendroflumethiazide	0.7	1.1	1.7	0.6	1.0	1.3
Ever smoked	0.7	1.3	2.4	-0.6	-1.0	-1.6
Leg fat percentage (left)	0.7	2.7	3.7	1.9	1.6	1.4
Risk taking	0.7	1.0	1.2	-0.8	-1.0	-1.1
Irritable Bowel Disease (IBD)	0.6	1.5	1.7	-1.2	-1.2	-1.3
Age at First Birth	0.6	0.9	1.3	1.0	1.1	0.7
Coronary Artery Disease (CAD)	0.6	0.8	1.2	0.9	1.1	0.5
HbA1C	0.6	0.6	1.2	0.8	-0.3	-1.1
Fed-up feelings	0.6	1.0	1.3	1.0	0.9	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	1.5	1.2	1.2	1.1
Illnesses of mother	0.6	0.7	1.7	0.3	0.7	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	2.9	-1.4	-1.0	-1.7
Leg fat percentage (right)	0.6	2.3	3.1	1.8	1.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.1	0.5	0.8	1.1
Osteoarthritis (self-reported)	0.6	0.7	1.5	1.2	0.7	0.4
Impedance of whole body	0.6	3.1	3.8	-1.9	-1.9	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	1.2	0.7	0.5
Bipolar Disorder (2011)	0.5	0.5	1.2	-0.5	1.1	0.2
Respiratory disease	0.5	1.1	1.3	-1.0	-0.9	-1.2
Standing height	0.5	5.4	7.2	-2.3	-1.9	-2.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	1.0	0.8	0.4
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-0.7	-1.2	-0.4
Pulse wave peak to peak time	0.5	0.6	0.7	0.5	0.9	0.8
Neck or shoulder pain in last month	0.5	0.8	1.7	1.3	0.6	0.5
Ever had bowel cancer screening	0.5	0.6	1.0	0.4	1.0	0.7
Eye problems/disorders: Cataract	0.5	0.6	1.2	-1.1	-0.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	0.3	1.1	0.7
Medication: Aspirin	0.5	0.6	1.7	1.3	0.3	0.2
Depression (Nagel 2018)	0.4	0.6	1.3	1.1	0.6	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.6	-1.1	-0.7	-1.2
Worry (Nagel 2018)	0.4	0.9	1.3	0.8	0.9	1.1
Taking other prescription medications	0.4	0.6	1.2	1.1	0.8	0.2
Alcohol usually taken with meals	0.4	0.6	1.2	-1.1	-0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.6	-0.4	-1.0
Arm fat percentage (right)	0.4	1.4	1.7	1.3	1.3	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.0	-1.1	-0.6
Arm fat mass (right)	0.4	1.8	2.4	1.5	1.5	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-0.3	-0.8	-1.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.7	0.8	0.6	0.7
Birth weight	0.4	0.8	2.1	-0.4	-0.2	-1.5
Leg fat mass (right)	0.4	1.4	2.1	1.5	1.2	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	0.7	0.4	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.5	0.7	0.7	0.7
Arm fat percentage (left)	0.4	1.6	2.0	1.4	1.3	1.1
Average weekly beer plus cider intake	0.4	0.6	1.5	1.2	0.5	0.4
Leg fat mass (left)	0.4	1.6	2.3	1.5	1.3	0.9
Schizophrenia (2018)	0.3	0.6	1.3	0.5	0.5	1.1
Major Depression (MDD)	0.3	0.3	0.7	0.8	0.3	-0.4
Ovarian Cancer	0.3	0.4	0.6	0.8	0.6	0.3
Height	0.3	5.6	6.5	-2.4	-2.1	-2.5
Systolic blood pressure, automated reading	0.3	0.9	1.3	1.1	0.8	0.8
Angina	0.3	0.4	1.0	1.0	0.5	0.3
Impedance of leg (left)	0.3	1.5	2.4	-1.2	-1.5	-0.9
Nervous feelings	0.3	0.6	0.7	0.8	0.6	0.9
Alcohol intake versus 10 years previously	0.3	0.5	0.9	1.0	0.7	-0.0
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.5	-0.9	-0.5	-1.2
Headache pain in last month	0.3	0.5	1.2	1.1	0.2	0.6
High blood pressure (siblings)	0.3	0.4	0.6	0.8	0.6	0.4
Comparative body size at age 10	0.3	0.7	1.6	0.4	0.7	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.3	0.9	0.5
Eye problems/disorders: None of the above	0.3	0.3	0.5	0.7	0.7	-0.2
Angina (self-reported)	0.3	0.4	0.9	0.9	0.5	0.2
Friendships satisfaction	0.3	0.4	0.6	0.6	0.8	0.5
Arm fat mass (left)	0.3	1.3	1.7	1.3	1.3	0.7
Average weekly champagne plus white wine intake	0.3	0.5	0.6	-0.7	-0.5	-0.8
Number of operations (self-reported)	0.3	0.4	0.8	0.6	0.9	0.4
Myopia	0.3	0.5	1.0	-0.6	-0.4	-1.0
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.9	0.1	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	-0.2	0.5	1.0
LDL Cholesterol	0.2	0.3	0.4	0.4	0.6	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.1	-0.5	-0.6
Smoking Status	0.2	0.5	0.7	0.8	0.8	0.4
Hypothyroidism (self reported)	0.2	0.5	1.2	-0.3	-0.6	-1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.6	0.3	0.3	0.8
Vitamin and mineral supplements	0.2	0.3	0.5	0.7	0.4	0.4
Supplements: Zinc	0.2	0.2	0.7	-0.1	0.1	0.8
Diabetes (mother)	0.2	0.3	0.5	-0.7	-0.5	-0.4
Pack years adult smoking proportion	0.2	0.3	0.7	0.8	0.5	0.4
Impedance of leg (right)	0.2	1.0	1.4	-1.1	-1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	1.0	0.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	-0.4	-0.5	-0.3
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.7	-0.2	-0.5
Sitting height	0.2	1.7	2.9	-1.2	-0.7	-1.7
Number of incorrect matches in round	0.2	0.4	0.6	0.5	0.5	0.8
Had menopause	0.2	0.3	0.5	0.7	0.5	0.3
Mouth/teeth dental problems	0.2	0.3	0.5	-0.7	-0.2	-0.6
Weight	0.2	1.2	1.7	1.3	1.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.3	0.5	0.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.1	-0.4	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	-0.2	-1.0	0.1
Prospective memory result	0.2	0.3	0.6	-0.4	-0.2	-0.8
Trunk predicted mass	0.2	0.9	1.6	1.0	1.3	0.3
Tense / ‘highly strung’	0.2	0.3	0.5	0.7	0.2	0.7
Arm fat-free mass (right)	0.2	1.1	1.7	1.3	1.2	0.3
Number of full brothers	0.2	0.3	0.7	0.8	-0.5	0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.7	0.3	0.2
Migraine (self-reported)	0.2	0.2	0.4	0.6	0.2	0.5
Medication: Allopurinol	0.2	0.3	0.6	-0.4	-0.4	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.1	0.7	0.4
Whole body fat mass	0.2	1.0	1.5	1.2	1.0	0.6
Arm predicted mass (right)	0.2	0.9	1.5	1.2	1.0	0.2
Medication: Aspirin	0.2	0.2	0.6	0.8	-0.0	-0.1
Hearing aid user	0.2	0.3	0.4	0.7	0.3	0.5
Medication: Atorvastatin	0.2	0.2	0.5	-0.1	0.7	0.2
Arm fat-free mass (left)	0.2	0.8	1.3	1.0	1.2	0.1
Irritability	0.2	0.4	0.8	0.5	0.3	0.9
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.1	0.4	0.8
Arm predicted mass (left)	0.2	1.0	1.5	1.2	1.2	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.5	-0.2	-0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.1	0.1	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.4	-0.2	-0.7
Lupus	0.1	0.2	0.4	0.7	-0.0	-0.2
Schizophrenia (2014)	0.1	0.2	0.4	-0.3	-0.1	0.7
Ulcerative Colitis	0.1	0.1	0.3	-0.5	-0.1	0.2
BMI	0.1	0.4	0.6	-0.5	-0.5	-0.8
Tanning	0.1	1.3	2.5	1.6	0.9	0.9
Hand grip strength (left)	0.1	0.2	0.4	0.6	0.2	-0.1
Average weekly spirits intake	0.1	0.1	0.2	-0.5	-0.3	-0.0
Relative age of first facial hair	0.1	0.2	0.3	-0.6	-0.2	-0.5
Severe depression (siblings)	0.1	0.1	0.2	-0.0	-0.4	-0.2
Hand grip strength (right)	0.1	0.4	0.7	-0.4	-0.8	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	0.2	0.6	0.4
Multivitamins +/- minerals	0.1	0.2	0.3	-0.6	-0.4	-0.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	0.2	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.1	0.3	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	-0.1	-0.0	0.6
Trunk fat-free mass	0.1	0.7	1.3	0.9	1.1	0.1
Hip circumference	0.1	0.4	0.7	0.8	0.7	0.5
Time employed in main current job	0.1	0.1	0.3	0.2	0.1	0.6
Falls in the last year	0.1	0.1	0.2	-0.1	-0.3	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.7	-0.1	-0.2
Lung cancer (father)	0.1	0.1	0.2	-0.0	0.3	0.4
Length of working week for main job	0.1	0.1	0.2	-0.1	-0.4	-0.3
Loud music exposure frequency	0.1	0.1	0.3	-0.1	-0.6	0.2
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.4	-0.2	-0.6
Gout (self-reported)	0.1	0.1	0.3	0.1	-0.1	-0.5
Body fat percentage	0.1	0.4	0.7	0.9	0.6	0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.8	0.3	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	0.2	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.7	0.3	0.1
Medication: Omeprazole	0.1	0.2	0.4	-0.2	-0.2	-0.6
Comparative height size at age 10	0.1	0.3	0.6	-0.5	-0.2	-0.8
Suffer from ‘nerves’	0.1	0.1	0.2	0.4	0.4	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.4	0.3	0.2
Whole body fat-free mass	0.1	0.5	0.8	0.8	0.9	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.3	-0.2	0.3
Whole body water mass	0.1	0.4	0.8	0.8	0.9	-0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.2	0.4	0.4	0.5
Basal metabolic rate	0.1	0.5	0.9	0.8	0.9	0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.7	0.5	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.6	0.1	0.1
Pain experienced in last month	0.1	0.2	0.6	-0.8	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.4	-0.2	-0.6
Alcohol drinker status: Previous	0.1	0.1	0.3	0.2	0.6	-0.2
Ulcerative Colitis (UC)	0.0	0.1	0.2	-0.0	0.2	0.4
Blood Eosinophil Count	0.0	0.0	0.0	0.0	-0.1	-0.2
Chronotype (morning person)	0.0	0.0	0.0	-0.1	0.1	-0.1
Hair Pigment	0.0	1.3	2.3	1.5	0.9	1.0
Leg fat-free mass (left)	0.0	0.2	0.2	0.4	0.5	-0.2
Trunk fat percentage	0.0	0.0	0.1	0.3	0.0	-0.1
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.2	-0.3	0.0
Relative age voice broke	0.0	0.1	0.1	0.3	0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.2	-0.0	-0.2
Leg predicted mass (left)	0.0	0.2	0.2	0.5	0.5	-0.2
Trunk fat mass	0.0	0.2	0.4	0.6	0.4	0.0
Had other major operations	0.0	0.0	0.1	0.3	-0.0	0.1
Pain all over the body in last month	0.0	0.0	0.1	0.0	0.3	-0.0
Asthma	0.0	0.1	0.2	0.0	-0.3	-0.4
Medication: Lansoprazole	0.0	0.0	0.0	0.2	0.1	-0.0
Birth weight of first child	0.0	0.1	0.1	0.2	-0.4	-0.1
Peak expiratory flow (PEF)	0.0	0.0	0.1	0.0	0.0	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.1	-0.2	-0.1
Medication: Paracetamol	0.0	0.0	0.1	0.3	0.1	0.0
Number of full sisters	0.0	0.0	0.0	-0.1	0.1	-0.2
Had major operations	0.0	0.0	0.1	-0.1	0.2	0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.2	0.3	0.1
Leg fat-free mass (right)	0.0	0.1	0.1	0.3	0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.1	-0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	-0.2	-0.0	0.2
Asthma (self-reported)	0.0	0.0	0.1	0.3	-0.0	-0.1
Leg predicted mass (right)	0.0	0.1	0.1	0.3	0.3	-0.4
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	0.2	-0.0
Medication: Paracetamol	0.0	0.1	0.2	0.4	0.1	0.0
Supplements: Calcium	0.0	0.0	0.1	0.2	-0.1	0.3
Pack years of smoking	0.0	0.1	0.1	0.4	-0.0	0.2

Hub : Genes

WFDC13

Models

Trait associations