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chr4:6,346,712-7,765,495

Best TWAS P=2.53e-17 · Best GWAS P=7.03e-127 conditioned to 2.92e-121

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TADA2B	0.02	0.01	blup	56	0.02	1.9e-03	-6.1	-8.5	2.5e-17	-0.04	0.07	0.38	TRUE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRPEL1	0.03	0.04	lasso	2	0.04	1.0e-05	-5.6	-5.7	1.0e-08	0.00	0.93	0.01	TRUE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	GRPEL1	0.05	0.04	blup	52	0.05	9.0e-06	-4.6	-7.7	1.7e-14	-0.02	0.32	0.65	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ36777	0.04	0.02	lasso	4	0.01	9.8e-03	-6.4	7.4	1.5e-13	0.03	0.01	0.92	FALSE
20	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ36777	0.13	0.02	blup	70	0.08	1.2e-03	-6.3	7.3	2.1e-13	0.03	0.02	0.49	FALSE
4	GTEx	Muscle Skeletal	GRPEL1	0.10	0.05	lasso	3	0.05	5.0e-06	-6.4	-7.1	9.3e-13	-0.01	0.99	0.00	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ36777	0.04	0.03	enet	6	0.03	9.9e-05	-6.4	7.1	1.5e-12	0.05	0.01	0.98	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ36777	0.11	0.15	enet	8	0.15	2.9e-16	-6.3	6.9	4.1e-12	0.02	0.06	0.94	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	GRPEL1	0.06	0.09	enet	9	0.10	3.1e-11	-5.6	-6.7	1.7e-11	-0.04	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	GRPEL1	0.03	0.02	blup	50	0.02	1.1e-03	-6.1	-6.7	2.2e-11	0.02	0.12	0.12	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GRPEL1	0.09	0.10	blup	52	0.12	5.4e-13	-6.3	-6.7	2.3e-11	0.00	1.00	0.00	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	TADA2B	0.05	0.04	lasso	4	0.03	1.3e-04	-6.3	6.7	3.0e-11	0.01	0.72	0.01	FALSE
7	YFS	Blood	TADA2B	0.09	0.11	lasso	4	0.10	5.6e-32	-6.3	-6.6	4.4e-11	-0.01	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLJ36777	0.07	0.04	blup	71	0.06	5.2e-07	-5.0	6.3	2.5e-10	0.00	0.10	0.88	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	TBC1D14	0.06	0.04	lasso	2	0.05	7.6e-06	-7.8	6.2	4.8e-10	0.06	0.66	0.01	FALSE
3	GTEx	Cells Transformed fibroblasts	GRPEL1	0.27	0.13	lasso	9	0.18	2.3e-13	-5.6	-6.2	5.6e-10	-0.01	1.00	0.00	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ36777	0.04	0.02	blup	71	0.03	2.4e-07	-6.3	6.1	1.2e-09	0.02	0.02	0.98	FALSE
2	GTEx	Cells EBV-transformed lymphocytes	GRPEL1	0.25	0.12	enet	7	0.06	3.9e-03	-6.1	-6.0	1.5e-09	0.00	0.38	0.03	FALSE
5	GTEx	Nerve Tibial	GRPEL1	0.16	0.07	lasso	4	0.06	2.9e-05	-6.3	-6.0	1.8e-09	0.00	0.67	0.02	FALSE
9	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ36777	0.06	0.00	blup	69	0.04	4.0e-03	-6.3	6.0	1.9e-09	0.00	0.01	0.65	FALSE
1	GTEx	Brain Cerebellum	GRPEL1	0.37	0.17	lasso	8	0.13	9.7e-05	-6.1	-6.0	2.4e-09	-0.01	0.31	0.04	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ36777	0.19	0.04	blup	71	0.10	8.1e-10	-5.0	5.2	1.6e-07	0.06	0.05	0.95	FALSE