Best TWAS P=2.53e-17 · Best GWAS P=7.03e-127 conditioned to 2.92e-121
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | GRPEL1 | 0.37 | 0.17 | lasso | 8 | 0.13 | 9.7e-05 | -6.1 | -6.0 | 2.4e-09 | -0.01 | 0.31 | 0.04 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | GRPEL1 | 0.25 | 0.12 | enet | 7 | 0.06 | 3.9e-03 | -6.1 | -6.0 | 1.5e-09 | 0.00 | 0.38 | 0.03 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | GRPEL1 | 0.27 | 0.13 | lasso | 9 | 0.18 | 2.3e-13 | -5.6 | -6.2 | 5.6e-10 | -0.01 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Muscle Skeletal | GRPEL1 | 0.10 | 0.05 | lasso | 3 | 0.05 | 5.0e-06 | -6.4 | -7.1 | 9.3e-13 | -0.01 | 0.99 | 0.00 | FALSE |
| 5 | GTEx | Nerve Tibial | GRPEL1 | 0.16 | 0.07 | lasso | 4 | 0.06 | 2.9e-05 | -6.3 | -6.0 | 1.8e-09 | 0.00 | 0.67 | 0.02 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | TADA2B | 0.05 | 0.04 | lasso | 4 | 0.03 | 1.3e-04 | -6.3 | 6.7 | 3.0e-11 | 0.01 | 0.72 | 0.01 | FALSE |
| 7 | YFS | Blood | TADA2B | 0.09 | 0.11 | lasso | 4 | 0.10 | 5.6e-32 | -6.3 | -6.6 | 4.4e-11 | -0.01 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ36777 | 0.04 | 0.02 | blup | 71 | 0.03 | 2.4e-07 | -6.3 | 6.1 | 1.2e-09 | 0.02 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | FLJ36777 | 0.06 | 0.00 | blup | 69 | 0.04 | 4.0e-03 | -6.3 | 6.0 | 1.9e-09 | 0.00 | 0.01 | 0.65 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FLJ36777 | 0.04 | 0.03 | enet | 6 | 0.03 | 9.9e-05 | -6.4 | 7.1 | 1.5e-12 | 0.05 | 0.01 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GRPEL1 | 0.09 | 0.10 | blup | 52 | 0.12 | 5.4e-13 | -6.3 | -6.7 | 2.3e-11 | 0.00 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TADA2B | 0.02 | 0.01 | blup | 56 | 0.02 | 1.9e-03 | -6.1 | -8.5 | 2.5e-17 | -0.04 | 0.07 | 0.38 | TRUE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FLJ36777 | 0.11 | 0.15 | enet | 8 | 0.15 | 2.9e-16 | -6.3 | 6.9 | 4.1e-12 | 0.02 | 0.06 | 0.94 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GRPEL1 | 0.06 | 0.09 | enet | 9 | 0.10 | 3.1e-11 | -5.6 | -6.7 | 1.7e-11 | -0.04 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | FLJ36777 | 0.04 | 0.02 | lasso | 4 | 0.01 | 9.8e-03 | -6.4 | 7.4 | 1.5e-13 | 0.03 | 0.01 | 0.92 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | GRPEL1 | 0.03 | 0.02 | blup | 50 | 0.02 | 1.1e-03 | -6.1 | -6.7 | 2.2e-11 | 0.02 | 0.12 | 0.12 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRPEL1 | 0.03 | 0.04 | lasso | 2 | 0.04 | 1.0e-05 | -5.6 | -5.7 | 1.0e-08 | 0.00 | 0.93 | 0.01 | TRUE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FLJ36777 | 0.07 | 0.04 | blup | 71 | 0.06 | 5.2e-07 | -5.0 | 6.3 | 2.5e-10 | 0.00 | 0.10 | 0.88 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GRPEL1 | 0.05 | 0.04 | blup | 52 | 0.05 | 9.0e-06 | -4.6 | -7.7 | 1.7e-14 | -0.02 | 0.32 | 0.65 | FALSE |
| 20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FLJ36777 | 0.13 | 0.02 | blup | 70 | 0.08 | 1.2e-03 | -6.3 | 7.3 | 2.1e-13 | 0.03 | 0.02 | 0.49 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | FLJ36777 | 0.19 | 0.04 | blup | 71 | 0.10 | 8.1e-10 | -5.0 | 5.2 | 1.6e-07 | 0.06 | 0.05 | 0.95 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | TBC1D14 | 0.06 | 0.04 | lasso | 2 | 0.05 | 7.6e-06 | -7.8 | 6.2 | 4.8e-10 | 0.06 | 0.66 | 0.01 | FALSE |