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chr4:1,947,324-4,219,590

Best TWAS P=3.36e-33 · Best GWAS P=1.24e-26 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	ROSMAP	Brain Pre-frontal Cortex	HGFAC	0.12	0.08	lasso	6	0.07	4.4e-09	-10.7	-12.0	3.4e-33	0.97	0.00	1.00	TRUE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C4orf44	0.03	0.02	blup	42	0.02	8.0e-04	-7.6	8.8	2.2e-18	-0.03	0.12	0.66	TRUE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	HGFAC	0.05	0.05	lasso	2	0.05	3.0e-06	-10.7	-8.2	2.7e-16	0.93	0.00	1.00	TRUE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS12	0.21	0.24	enet	9	0.27	8.9e-16	-8.1	-8.2	3.8e-16	0.25	1.00	0.00	TRUE
17	GTEx	Pancreas	LRPAP1	0.16	0.08	enet	8	0.10	3.6e-05	2.3	6.8	1.5e-11	-0.14	0.38	0.03	TRUE
16	GTEx	Pancreas	GRK4	0.14	0.05	lasso	9	0.03	3.0e-02	-4.9	6.5	8.6e-11	0.01	0.47	0.09	TRUE
23	GTEx	Uterus	GRK4	0.31	0.24	enet	29	0.32	2.5e-07	-4.8	6.5	8.6e-11	-0.16	0.37	0.04	TRUE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	C4orf44	0.04	0.01	enet	18	0.02	1.6e-03	-8.1	5.8	6.0e-09	-0.01	0.01	0.80	TRUE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	GRK4	0.08	0.07	blup	77	0.09	4.4e-06	-4.3	5.5	4.0e-08	-0.15	0.94	0.04	TRUE
44	The Cancer Genome Atlas	Thyroid Carcinoma	RGS12	0.08	0.01	blup	108	0.01	2.4e-02	9.3	9.8	1.2e-22	-0.17	0.02	0.11	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	C4orf44	0.03	0.04	lasso	4	0.05	2.9e-06	-7.6	8.6	7.1e-18	-0.05	0.01	0.98	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	C4orf44	0.15	0.20	lasso	4	0.20	2.9e-19	-8.1	8.4	3.1e-17	-0.07	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	RGS12	0.58	0.10	enet	25	0.24	2.4e-06	-8.7	-8.1	3.9e-16	0.05	0.12	0.05	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C4orf44	0.03	0.04	lasso	1	0.03	1.0e-04	-8.0	8.0	1.0e-15	-0.08	0.02	0.98	FALSE
3	GTEx	Brain Cerebellum	LRPAP1	0.54	0.03	lasso	10	0.18	7.3e-06	2.3	7.6	2.1e-14	-0.33	0.13	0.05	FALSE
1	GTEx	Adipose Visceral Omentum	RP11-529E10.6	0.19	0.01	lasso	7	0.01	1.2e-01	-3.5	-7.4	1.7e-13	0.26	0.11	0.06	FALSE
29	YFS	Blood	LRPAP1	0.05	0.04	enet	12	0.03	1.9e-11	-6.6	-7.3	3.3e-13	0.18	1.00	0.00	FALSE
25	GTEx	Whole Blood	LRPAP1	0.13	0.12	lasso	5	0.12	8.3e-11	-6.9	-6.9	4.6e-12	0.12	1.00	0.00	FALSE
11	GTEx	Heart Left Ventricle	RP11-529E10.6	0.22	0.12	lasso	5	0.10	6.0e-06	-6.9	-6.9	5.5e-12	0.13	0.97	0.00	FALSE
5	GTEx	Breast Mammary Tissue	RP11-529E10.6	0.17	0.07	lasso	4	0.06	7.9e-04	-6.9	-6.6	5.5e-11	0.14	0.11	0.07	FALSE
4	GTEx	Brain Hippocampus	RP11-529E10.6	0.50	-0.01	enet	5	-0.01	4.4e-01	4.3	-6.5	7.2e-11	0.38	0.05	0.09	FALSE
13	GTEx	Muscle Skeletal	HTT	0.22	0.02	lasso	9	0.06	1.3e-06	-7.1	-6.5	1.1e-10	0.08	0.69	0.11	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRPAP1	0.05	0.00	blup	52	0.02	2.8e-02	2.2	6.4	1.2e-10	-0.26	0.02	0.63	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	SH3BP2	0.08	0.03	blup	53	0.02	2.8e-02	4.2	6.3	2.5e-10	-0.08	0.01	0.14	FALSE
21	GTEx	Thyroid	RGS12	0.09	0.00	enet	21	0.02	2.1e-02	4.3	6.3	3.5e-10	-0.12	0.14	0.04	FALSE
22	GTEx	Thyroid	NOP14-AS1	0.18	0.09	lasso	8	0.11	1.3e-08	-5.1	5.8	7.7e-09	-0.13	1.00	0.00	FALSE
12	GTEx	Lung	ADD1	0.09	0.02	enet	6	0.01	3.5e-02	5.6	5.8	9.0e-09	-0.13	0.55	0.02	FALSE
15	GTEx	Ovary	GRK4	0.25	0.19	lasso	8	0.18	3.6e-05	-4.9	5.7	9.6e-09	-0.07	0.27	0.04	FALSE
36	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GRK4	0.13	0.10	blup	76	0.11	8.4e-08	-5.1	5.7	1.1e-08	-0.06	1.00	0.00	FALSE
18	GTEx	Spleen	GRK4	0.24	0.16	lasso	5	0.12	4.8e-04	-4.9	5.7	1.2e-08	0.00	0.24	0.04	FALSE
24	GTEx	Whole Blood	GRK4	0.08	0.10	lasso	4	0.10	1.0e-09	-4.9	5.7	1.2e-08	-0.06	1.00	0.00	FALSE
28	YFS	Blood	FAM193A	0.02	0.00	enet	18	0.01	5.8e-04	-4.8	5.7	1.2e-08	-0.09	0.27	0.02	FALSE
26	GTEx	Whole Blood	RP11-529E10.6	0.20	0.08	lasso	7	0.07	7.8e-07	-6.6	-5.7	1.6e-08	0.17	1.00	0.00	FALSE
2	GTEx	Brain Cerebellum	GRK4	0.41	0.36	lasso	7	0.34	7.7e-11	-4.9	5.6	2.8e-08	-0.02	0.99	0.00	FALSE
14	GTEx	Nerve Tibial	RP11-529E10.6	0.11	0.02	lasso	3	0.02	8.6e-03	-6.9	-5.5	3.4e-08	0.15	0.43	0.03	FALSE
19	GTEx	Spleen	RP11-529E10.6	0.48	0.04	enet	14	0.14	2.0e-04	2.6	-5.4	5.9e-08	0.24	0.08	0.13	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	RP11-529E10.6	0.27	0.03	enet	18	0.02	8.3e-02	2.3	-5.4	6.0e-08	0.19	0.04	0.08	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRK4	0.10	0.14	enet	16	0.14	4.6e-15	-5.0	5.4	7.3e-08	-0.02	1.00	0.00	FALSE
8	GTEx	Cells Transformed fibroblasts	NOP14	0.12	0.06	enet	11	0.09	2.9e-07	-4.4	5.4	8.5e-08	-0.10	0.92	0.00	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	GRK4	0.17	0.24	lasso	6	0.24	1.2e-17	-5.0	5.2	2.1e-07	-0.03	1.00	0.00	FALSE
20	GTEx	Testis	LRPAP1	0.56	0.33	lasso	10	0.46	1.8e-22	2.4	5.2	2.3e-07	-0.15	1.00	0.00	FALSE
6	GTEx	Breast Mammary Tissue (Female)	RP11-529E10.6	0.19	0.04	enet	9	0.03	4.2e-02	4.0	-5.2	2.5e-07	0.30	0.04	0.16	FALSE
9	GTEx	Cells Transformed fibroblasts	GRK4	0.32	0.35	lasso	7	0.37	3.1e-29	-5.1	5.2	2.5e-07	-0.04	1.00	0.00	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	GRK4	0.37	0.23	lasso	9	0.22	2.2e-08	-4.9	5.2	2.5e-07	-0.02	0.98	0.00	FALSE