[Hub]/) : Traits : Blood Platelet Count :

chr4:1,947,324-4,219,590

Best TWAS P=3.36e-33 · Best GWAS P=1.24e-26 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum RP11-529E10.6 0.19 0.01 lasso 7 0.01 1.2e-01 -3.5 -7.4 1.7e-13 0.26 0.11 0.06 FALSE
2 GTEx Brain Cerebellum GRK4 0.41 0.36 lasso 7 0.34 7.7e-11 -4.9 5.6 2.8e-08 -0.02 0.99 0.00 FALSE
3 GTEx Brain Cerebellum LRPAP1 0.54 0.03 lasso 10 0.18 7.3e-06 2.3 7.6 2.1e-14 -0.33 0.13 0.05 FALSE
4 GTEx Brain Hippocampus RP11-529E10.6 0.50 -0.01 enet 5 -0.01 4.4e-01 4.3 -6.5 7.2e-11 0.38 0.05 0.09 FALSE
5 GTEx Breast Mammary Tissue RP11-529E10.6 0.17 0.07 lasso 4 0.06 7.9e-04 -6.9 -6.6 5.5e-11 0.14 0.11 0.07 FALSE
6 GTEx Breast Mammary Tissue (Female) RP11-529E10.6 0.19 0.04 enet 9 0.03 4.2e-02 4.0 -5.2 2.5e-07 0.30 0.04 0.16 FALSE
7 GTEx Cells EBV-transformed lymphocytes RP11-529E10.6 0.27 0.03 enet 18 0.02 8.3e-02 2.3 -5.4 6.0e-08 0.19 0.04 0.08 FALSE
8 GTEx Cells Transformed fibroblasts NOP14 0.12 0.06 enet 11 0.09 2.9e-07 -4.4 5.4 8.5e-08 -0.10 0.92 0.00 FALSE
9 GTEx Cells Transformed fibroblasts GRK4 0.32 0.35 lasso 7 0.37 3.1e-29 -5.1 5.2 2.5e-07 -0.04 1.00 0.00 FALSE
10 GTEx Esophagus Gastroesophageal Junction GRK4 0.37 0.23 lasso 9 0.22 2.2e-08 -4.9 5.2 2.5e-07 -0.02 0.98 0.00 FALSE
11 GTEx Heart Left Ventricle RP11-529E10.6 0.22 0.12 lasso 5 0.10 6.0e-06 -6.9 -6.9 5.5e-12 0.13 0.97 0.00 FALSE
12 GTEx Lung ADD1 0.09 0.02 enet 6 0.01 3.5e-02 5.6 5.8 9.0e-09 -0.13 0.55 0.02 FALSE
13 GTEx Muscle Skeletal HTT 0.22 0.02 lasso 9 0.06 1.3e-06 -7.1 -6.5 1.1e-10 0.08 0.69 0.11 FALSE
14 GTEx Nerve Tibial RP11-529E10.6 0.11 0.02 lasso 3 0.02 8.6e-03 -6.9 -5.5 3.4e-08 0.15 0.43 0.03 FALSE
15 GTEx Ovary GRK4 0.25 0.19 lasso 8 0.18 3.6e-05 -4.9 5.7 9.6e-09 -0.07 0.27 0.04 FALSE
16 GTEx Pancreas GRK4 0.14 0.05 lasso 9 0.03 3.0e-02 -4.9 6.5 8.6e-11 0.01 0.47 0.09 TRUE
17 GTEx Pancreas LRPAP1 0.16 0.08 enet 8 0.10 3.6e-05 2.3 6.8 1.5e-11 -0.14 0.38 0.03 TRUE
18 GTEx Spleen GRK4 0.24 0.16 lasso 5 0.12 4.8e-04 -4.9 5.7 1.2e-08 0.00 0.24 0.04 FALSE
19 GTEx Spleen RP11-529E10.6 0.48 0.04 enet 14 0.14 2.0e-04 2.6 -5.4 5.9e-08 0.24 0.08 0.13 FALSE
20 GTEx Testis LRPAP1 0.56 0.33 lasso 10 0.46 1.8e-22 2.4 5.2 2.3e-07 -0.15 1.00 0.00 FALSE
21 GTEx Thyroid RGS12 0.09 0.00 enet 21 0.02 2.1e-02 4.3 6.3 3.5e-10 -0.12 0.14 0.04 FALSE
22 GTEx Thyroid NOP14-AS1 0.18 0.09 lasso 8 0.11 1.3e-08 -5.1 5.8 7.7e-09 -0.13 1.00 0.00 FALSE
23 GTEx Uterus GRK4 0.31 0.24 enet 29 0.32 2.5e-07 -4.8 6.5 8.6e-11 -0.16 0.37 0.04 TRUE
24 GTEx Whole Blood GRK4 0.08 0.10 lasso 4 0.10 1.0e-09 -4.9 5.7 1.2e-08 -0.06 1.00 0.00 FALSE
25 GTEx Whole Blood LRPAP1 0.13 0.12 lasso 5 0.12 8.3e-11 -6.9 -6.9 4.6e-12 0.12 1.00 0.00 FALSE
26 GTEx Whole Blood RP11-529E10.6 0.20 0.08 lasso 7 0.07 7.8e-07 -6.6 -5.7 1.6e-08 0.17 1.00 0.00 FALSE
27 ROSMAP Brain Pre-frontal Cortex HGFAC 0.12 0.08 lasso 6 0.07 4.4e-09 -10.7 -12.0 3.4e-33 0.97 0.00 1.00 TRUE
28 YFS Blood FAM193A 0.02 0.00 enet 18 0.01 5.8e-04 -4.8 5.7 1.2e-08 -0.09 0.27 0.02 FALSE
29 YFS Blood LRPAP1 0.05 0.04 enet 12 0.03 1.9e-11 -6.6 -7.3 3.3e-13 0.18 1.00 0.00 FALSE
30 The Cancer Genome Atlas Colon Adenocarcinoma RGS12 0.21 0.24 enet 9 0.27 8.9e-16 -8.1 -8.2 3.8e-16 0.25 1.00 0.00 TRUE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C4orf44 0.03 0.02 blup 42 0.02 8.0e-04 -7.6 8.8 2.2e-18 -0.03 0.12 0.66 TRUE
32 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma LRPAP1 0.05 0.00 blup 52 0.02 2.8e-02 2.2 6.4 1.2e-10 -0.26 0.02 0.63 FALSE
33 The Cancer Genome Atlas Lung Adenocarcinoma C4orf44 0.03 0.04 lasso 4 0.05 2.9e-06 -7.6 8.6 7.1e-18 -0.05 0.01 0.98 FALSE
34 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C4orf44 0.03 0.04 lasso 1 0.03 1.0e-04 -8.0 8.0 1.0e-15 -0.08 0.02 0.98 FALSE
35 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GRK4 0.10 0.14 enet 16 0.14 4.6e-15 -5.0 5.4 7.3e-08 -0.02 1.00 0.00 FALSE
36 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GRK4 0.13 0.10 blup 76 0.11 8.4e-08 -5.1 5.7 1.1e-08 -0.06 1.00 0.00 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma C4orf44 0.04 0.01 enet 18 0.02 1.6e-03 -8.1 5.8 6.0e-09 -0.01 0.01 0.80 TRUE
38 The Cancer Genome Atlas Prostate Adenocarcinoma HGFAC 0.05 0.05 lasso 2 0.05 3.0e-06 -10.7 -8.2 2.7e-16 0.93 0.00 1.00 TRUE
39 The Cancer Genome Atlas Rectum Adenocarcinoma RGS12 0.58 0.10 enet 25 0.24 2.4e-06 -8.7 -8.1 3.9e-16 0.05 0.12 0.05 FALSE
40 The Cancer Genome Atlas Soft Tissue Sarcoma GRK4 0.08 0.07 blup 77 0.09 4.4e-06 -4.3 5.5 4.0e-08 -0.15 0.94 0.04 TRUE
41 The Cancer Genome Atlas Soft Tissue Sarcoma SH3BP2 0.08 0.03 blup 53 0.02 2.8e-02 4.2 6.3 2.5e-10 -0.08 0.01 0.14 FALSE
42 The Cancer Genome Atlas Stomach Adenocarcinoma GRK4 0.17 0.24 lasso 6 0.24 1.2e-17 -5.0 5.2 2.1e-07 -0.03 1.00 0.00 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma C4orf44 0.15 0.20 lasso 4 0.20 2.9e-19 -8.1 8.4 3.1e-17 -0.07 0.02 0.98 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma RGS12 0.08 0.01 blup 108 0.01 2.4e-02 9.3 9.8 1.2e-22 -0.17 0.02 0.11 FALSE