Hub : Genes

TADA2B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0325	0.0123	0.0029	0.000	0.001	0.000	0.001	0.000	4.0e-01	1.1e-01	2.9e-01	1.1e-01	4.5e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.0495	0.0197	0.0056	0.044	0.009	0.025	0.016	0.028	2.0e-06	2.2e-02	3.1e-04	3.0e-03	1.3e-04
3	YFS	Blood	0.0889	0.0148	0.0000	0.109	0.084	0.101	0.102	0.103	8.6e-34	5.5e-26	2.6e-31	1.1e-31	5.6e-32
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0227	0.0124	0.0028	0.010	0.021	0.014	NA	0.012	2.3e-02	1.9e-03	8.7e-03	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.9	4.5	5.1	2.3	2.0	-2.0	-2.3
Bipolar Disorder or Schizophrenia	2.2	5.4	8.1	1.4	2.4	-2.4	-2.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.4	0.1	-0.3	-0.7
Depression (Nagel 2018)	0.1	0.2	0.4	0.7	-0.0	-0.1	-0.6
Intelligence (Savage-Jansen 2018)	0.8	2.6	4.8	-2.2	-1.2	1.3	1.6
Neuroticism (Nagel 2018)	0.8	2.0	3.0	-0.1	1.7	-1.7	-1.4
Schizophrenia (2018)	0.9	1.9	3.4	-0.0	1.4	-1.5	-1.9
Schizophrenia vs Biploar Disorder	1.2	1.5	5.1	-2.3	-0.6	0.6	0.5
Worry (Nagel 2018)	0.3	0.6	0.9	-0.6	0.9	-1.0	-0.6
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	1.1	1.0	-1.0	-0.3
Alzheimer’s Disease (in father)	0.7	0.8	1.3	0.1	-1.2	1.1	0.8
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	0.5	-0.6	0.6	0.8
Crohns Disease (2017)	2.8	6.1	9.4	2.3	2.2	-2.1	-3.1
Irritable Bowel Disease (IBD)	2.8	6.7	8.1	2.1	2.7	-2.7	-2.8
Ulcerative Colitis (UC)	1.5	2.9	4.4	0.6	2.1	-2.1	-1.6
Major Depression (MDD)	0.4	0.5	2.2	0.0	0.0	0.0	1.5
Reaction Time	0.8	1.6	2.3	-0.1	1.5	-1.5	-1.4
Verbal and Numeric Reasoning (VNR)	0.8	1.8	3.8	-2.0	-0.7	0.8	1.5
Breast Cancer	0.7	1.7	2.3	0.1	-1.4	1.5	1.5
Ovarian Cancer	0.7	1.0	2.5	-1.6	0.6	-0.6	-0.8
Prostate Cancer	0.2	0.2	0.4	-0.4	0.6	-0.6	0.3
Age at First Birth	0.6	0.9	1.3	-0.7	-0.8	1.1	1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.6	0.2	-0.2	-0.8
Coronary Artery Disease (CAD)	0.6	0.7	1.9	1.4	-0.7	0.6	0.5
Crohns Disease (2012)	3.6	5.8	9.4	2.4	2.0	-2.0	-3.1
Mean Putamen Volume	2.5	2.9	4.8	-0.7	-1.7	1.8	2.2
Fasting Glucose	2.5	3.0	8.4	-2.9	-0.6	0.7	1.7
HbA1C	1.8	2.0	4.8	1.2	0.8	-1.1	-2.2
HDL Cholesterol	0.7	1.1	1.9	-0.3	1.1	-1.2	-1.4
LDL Cholesterol	1.2	1.9	3.7	1.9	1.0	-1.1	-1.3
Lupus	2.1	3.1	4.5	-0.1	2.1	-2.0	-2.0
Neuroticism (2016)	0.2	0.2	0.5	0.3	0.6	-0.7	-0.2
Primary Biliary Cirrhosis	0.4	0.5	0.7	-0.2	-0.8	0.8	0.8
Rheumatoid Arthritis	1.9	2.6	3.9	-2.0	-1.4	1.4	1.6
Schizophrenia (2014)	0.7	1.5	3.0	0.4	1.2	-1.3	-1.7
Triglycerides	0.0	0.0	0.0	-0.1	0.2	-0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.6	0.1	-1.3	1.1	1.0
Ulcerative Colitis	2.3	3.3	4.9	1.2	2.0	-2.2	-1.6
Blood Eosinophil Count	2.0	15.3	22.7	-2.3	-4.5	4.8	3.6
Blood Platelet Count	3.5	40.6	71.7	1.7	6.7	-6.6	-8.5
Blood Red Count	0.6	5.8	11.8	-0.7	-2.4	2.3	3.4
Blood White Count	1.2	9.1	20.8	-0.3	2.9	-2.7	-4.6
Heel T-Score	0.2	1.8	4.9	-2.2	-0.4	0.6	1.4
BMI	2.3	13.4	16.9	-3.5	-3.5	3.5	4.1
Height	1.4	27.0	45.3	3.1	5.1	-5.2	-6.7
Waist Hip Ratio (WHR)	0.3	1.2	2.7	-1.7	-0.2	0.1	1.4
Systolic Blood Pressure	0.6	2.9	3.9	0.3	-1.9	1.9	2.0
Smoking Status	0.3	0.8	1.4	-0.1	-1.2	1.2	0.7
Allergy or Eczema	0.2	0.5	0.6	0.8	-0.6	0.7	0.7
Cardiovascular Disease	1.8	5.8	8.5	-0.5	-2.7	2.7	2.9
Hypothyroidism (self reported)	0.2	0.4	0.5	0.7	-0.7	0.6	0.5
Respiratory disease	0.1	0.2	0.6	-0.8	-0.1	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	1.8	3.4	4.9	0.8	-2.2	2.1	1.8
Lung FEV1/FVC ratio	0.6	3.0	5.2	-2.3	-1.5	1.5	1.5
Lung FVC	0.1	0.3	0.6	-0.3	0.6	-0.8	-0.1
Neuroticism	0.4	0.9	1.2	-0.6	1.1	-1.1	-0.8
Chronotype (morning person)	0.2	0.4	1.6	-1.3	0.0	0.0	-0.0
Hair Pigment	0.1	1.6	2.4	-0.2	-1.4	1.3	1.6
Tanning	0.0	0.5	1.0	0.3	0.7	-0.8	-1.0
Hand grip strength (left)	0.3	0.9	1.2	1.1	0.9	-0.9	-0.8
Number of treatments/medications taken	7.8	14.0	22.0	0.0	-4.7	4.5	3.7
Average weekly spirits intake	3.9	4.8	6.9	0.7	-2.6	2.6	2.3
Sensitivity / hurt feelings	1.9	3.3	5.6	-0.2	2.3	-2.4	-1.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.8	0.1	0.8	-0.9	-0.8
Hearing difficulty/problems: Yes	1.0	1.5	4.8	-2.2	-0.4	0.5	0.9
Relative age of first facial hair	1.2	2.6	3.0	1.4	1.6	-1.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	-0.2	-0.9	0.9	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.2	-0.5	0.6	0.3
Ever had hysterectomy (womb removed)	0.3	0.3	1.1	1.1	-0.1	0.1	-0.3
Systolic blood pressure, automated reading	0.6	1.7	2.7	0.5	-1.4	1.4	1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.1	0.4	-1.4	1.4	0.5
Angina	1.4	1.8	2.1	1.0	-1.5	1.4	1.5
Medication for hormone replacement therapy	3.6	4.0	5.3	-0.9	-2.2	2.2	2.3
Vitamin and mineral supplements	3.9	5.3	7.0	1.3	2.5	-2.6	-2.5
Supplements: Zinc	0.7	0.7	2.3	1.5	0.2	-0.2	-0.8
Medication: Co-codamol	2.1	2.5	3.5	-1.1	-1.8	1.9	1.4
Medication: Metformin	0.9	1.3	2.2	0.4	-1.5	1.4	1.0
Diabetes (father)	2.6	3.2	5.3	-2.3	-1.3	1.5	1.9
Diabetes (mother)	1.4	1.8	2.3	-1.5	-1.4	1.3	1.1
Severe depression (siblings)	0.1	0.1	0.2	-0.1	-0.4	0.5	-0.4
Pack years adult smoking proportion	0.2	0.3	0.5	-0.2	-0.6	0.3	-0.7
Impedance of leg (right)	0.3	1.5	3.3	0.2	1.2	-1.1	-1.8
Leg fat-free mass (left)	0.0	0.0	0.1	0.2	-0.2	0.1	0.2
Trunk fat percentage	0.6	2.5	3.2	-1.3	-1.6	1.6	1.8
Hand grip strength (right)	1.5	4.2	4.7	1.9	2.1	-2.2	-2.0
Townsend deprivation index at recruitment	1.1	1.5	2.0	-1.4	-1.1	1.1	1.2
Current tobacco smoking	0.4	0.7	1.2	0.7	0.7	-0.8	-1.1
Average weekly fortified wine intake	1.9	2.2	2.8	-0.8	-1.6	1.7	1.7
Maternal smoking around birth	0.1	0.1	0.1	0.3	0.3	-0.3	-0.4
Fed-up feelings	0.3	0.5	0.8	-0.3	0.7	-0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	1.3	1.1	0.7	-0.8	-1.1
Relative age voice broke	1.0	1.5	2.1	1.4	1.3	-1.3	-0.6
Taking other prescription medications	7.7	11.9	17.6	-1.4	-4.2	4.0	3.4
Age when periods started (menarche)	0.2	0.4	1.3	0.2	0.4	-0.6	-1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.6	1.3	0.1	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	4.1	9.2	12.1	-1.1	-3.4	3.5	3.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.5	0.4	-0.3	-0.4
Qualifications: CSEs or equivalent	1.7	2.3	3.3	0.1	1.6	-1.8	-1.8
Serious illness, injury or assault to yourself	0.6	0.7	2.7	1.6	-0.1	0.1	-0.2
High blood pressure	0.5	1.4	1.9	0.7	-1.4	1.2	1.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.1	1.0	0.0	0.1	0.1
Multivitamins +/- minerals	3.7	4.7	5.0	-2.2	-2.2	2.2	2.0
Stomach or abdominal pain in last month	0.8	1.0	2.7	-0.9	-0.5	0.6	1.6
Supplements: Glucosamine	1.0	1.3	2.2	0.3	-1.2	1.5	1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	-1.1	-0.6	0.6	0.5
Medication: Atenolol	1.0	1.3	1.8	1.1	-1.1	1.1	1.4
Medication: Levothyroxine sodium	1.6	2.7	3.7	0.4	-1.9	1.8	1.9
Sitting height	1.4	9.6	14.3	3.0	2.7	-2.8	-3.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.1	0.3	-0.3	-0.8
High blood pressure (mother)	3.7	5.2	6.7	-1.4	-2.4	2.5	2.6
Body mass index (BMI)	2.3	9.9	15.6	-1.4	-3.3	3.3	4.0
Impedance of leg (left)	0.3	1.3	2.8	0.3	1.1	-1.1	-1.7
Leg predicted mass (left)	0.0	0.0	0.1	0.0	-0.2	0.1	0.2
Trunk fat mass	0.4	1.6	2.2	-0.6	-1.4	1.4	1.5
Waist circumference	1.2	4.2	6.5	-0.4	-2.3	2.2	2.5
Number of incorrect matches in round	0.3	0.5	0.8	0.9	-0.6	0.7	0.8
Past tobacco smoking	1.4	2.6	4.0	0.8	2.0	-2.0	-1.4
Alcohol usually taken with meals	4.6	7.4	10.6	-0.8	-2.9	3.2	3.3
Nervous feelings	0.3	0.5	1.6	-1.3	0.4	-0.6	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	0.2	0.7	-0.7	-0.4
Hearing difficulty/problems with background noise	2.1	3.4	4.2	-2.1	-1.8	1.9	1.6
Hair/balding pattern: Pattern 2	1.2	1.6	4.0	-2.0	0.9	-0.9	-0.8
Had menopause	0.7	0.9	3.5	1.9	0.2	-0.1	0.0
Had other major operations	3.3	4.1	6.5	1.4	-2.4	2.5	1.4
Forced vital capacity (FVC)	1.3	5.2	7.1	1.4	2.6	-2.7	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	4.3	-0.7	-2.0	2.0	2.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.8	1.3	-0.1	0.1	-0.3
Qualifications: None of the above	0.9	1.8	3.8	1.9	0.7	-1.0	-1.4
Financial difficulties in last 2 years	0.4	0.5	1.3	-1.1	0.5	-0.7	-0.3
Mouth/teeth dental problems	0.5	0.8	2.2	1.5	0.3	-0.4	-0.8
Heart attack	0.4	0.5	1.9	1.4	-0.2	0.1	-0.1
Allergy	0.1	0.2	0.3	-0.5	0.5	-0.5	-0.2
Pain all over the body in last month	0.4	0.4	0.8	-0.1	-0.9	0.8	0.4
Diabetes (self-reported)	1.2	1.8	2.6	0.6	-1.6	1.5	1.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	-0.6	-0.3	0.3	0.4
Medication: Ramipril	1.0	1.2	2.1	-0.9	-1.5	1.3	0.6
Medication: Simvastatin	1.2	1.8	3.0	0.4	-1.7	1.6	1.3
Fluid intelligence score	1.1	2.2	6.0	-2.5	-0.7	0.7	1.4
Illnesses of siblings	0.5	0.8	1.0	-0.6	1.0	-1.0	-0.8
Neuroticism score	0.6	1.3	2.0	-0.3	1.4	-1.4	-1.1
Weight	0.2	1.0	1.4	0.3	-1.1	1.1	1.2
Impedance of arm (right)	1.3	6.0	9.1	0.6	2.7	-2.7	-3.0
Arm fat percentage (right)	1.6	6.1	9.9	-1.7	-2.4	2.4	3.1
Trunk fat-free mass	0.1	0.4	1.4	1.2	0.2	-0.3	-0.4
Hip circumference	0.3	1.4	2.0	0.5	-1.3	1.4	1.3
Time employed in main current job	0.0	0.0	0.1	0.1	-0.1	0.2	0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.6	-0.3	0.3	-0.6
Father’s age at death	0.7	0.9	1.0	-1.0	-0.8	1.0	1.0
Worrier / anxious feelings	0.7	1.2	1.9	-1.4	1.1	-1.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.4	0.2	-0.3	0.3
Falls in the last year	0.2	0.3	0.5	-0.2	-0.6	0.7	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.4	0.3	-0.4	-0.9
Number of live births	5.4	7.6	14.8	-3.8	-2.0	2.0	2.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.6	0.7	1.6	-1.6	-1.0
Pulse rate	0.2	0.3	0.4	0.0	0.6	-0.6	-0.6
Happiness	0.6	0.7	1.1	0.6	1.0	-1.0	-0.7
Noisy workplace	1.6	2.0	3.1	0.4	1.6	-1.8	-1.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	0.7	0.2	0.1	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.9	0.1	-0.1	-0.2
Mouth/teeth dental problems: Dentures	0.6	1.1	4.2	-2.1	-0.1	0.1	0.3
Asthma	0.3	0.6	1.7	0.2	0.6	-0.5	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.4	1.8	-0.2	0.3	-0.1
Medication: Cholesterol lowering	1.9	2.9	4.4	2.1	-1.8	1.6	1.3
Depression (self-reported)	0.3	0.4	0.8	-0.6	0.4	-0.5	-0.9
Medication: Lansoprazole	0.9	1.0	1.9	-0.3	-1.0	1.0	1.4
Prospective memory result	0.1	0.2	0.5	0.7	0.1	-0.2	-0.3
Lung cancer (father)	0.5	0.6	0.8	-0.1	0.9	-0.9	-0.8
Illnesses of mother	3.4	4.2	4.6	2.1	1.9	-2.0	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	-0.4	0.6	-0.7	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.2	0.2	-0.4	-0.2
Impedance of arm (left)	1.0	4.4	6.0	0.7	2.4	-2.4	-2.4
Arm fat mass (right)	1.3	5.3	8.4	-1.1	-2.4	2.4	2.9
Trunk predicted mass	0.1	0.4	1.3	1.1	0.2	-0.3	-0.4
Standing height	2.1	20.9	31.5	3.4	4.5	-4.5	-5.6
Length of working week for main job	0.8	0.9	2.0	1.4	0.6	-0.6	-0.9
Exposure to tobacco smoke at home	0.4	0.4	0.6	-0.8	-0.7	0.7	-0.1
Breastfed as a baby	1.6	2.0	2.9	0.0	-1.5	1.7	1.7
Tense / ‘highly strung’	0.0	0.0	0.1	-0.3	0.2	-0.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.6	1.6	0.1	-0.3	-0.6
Hair/balding pattern: Pattern 4	0.4	1.0	1.4	-0.1	1.1	-1.1	-1.2
Birth weight of first child	4.2	7.6	8.5	2.4	2.9	-2.9	-2.8
Peak expiratory flow (PEF)	0.5	1.2	2.4	-0.6	-0.9	1.1	1.6
Pulse wave reflection index	0.2	0.3	1.0	-0.0	-0.2	0.1	1.0
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.7	0.4	1.0	-1.0	-1.3
Loud music exposure frequency	1.0	1.1	1.8	-0.7	-1.3	1.3	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.1	-1.5	-0.4	0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.3	-0.4	-0.7	0.9	1.8
Blood clot in the leg (DVT)	0.4	0.5	1.3	0.1	-0.7	0.5	1.2
Medication: Paracetamol	2.5	4.1	4.8	-2.2	-2.0	1.9	1.9
Headache pain in last month	0.9	1.6	2.2	0.5	-1.5	1.5	1.3
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	6.0	-0.9	2.4	-2.2	-1.6
Glaucoma (self-reported)	1.9	2.2	2.5	1.3	-1.5	1.5	1.6
Gout (self-reported)	1.9	2.6	4.1	0.4	-2.0	2.0	1.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.6	1.1	-1.3	1.2	1.1
Medication: Amlodipine	0.1	0.2	0.4	0.6	-0.5	0.3	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	0.5	0.1	-0.2	-1.1
Birth weight	1.1	2.4	5.7	-0.5	1.3	-1.3	-2.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.2	0.4	-0.4	-0.6
High blood pressure (siblings)	0.1	0.2	0.6	0.8	0.1	-0.1	0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	2.1	0.2	1.3	-1.4	-1.2
Body fat percentage	1.3	5.1	6.9	-1.3	-2.4	2.4	2.6
Leg fat percentage (right)	2.1	7.6	10.2	-1.0	-3.1	3.1	3.2
Arm fat-free mass (right)	0.0	0.2	0.5	0.7	-0.5	0.4	0.2
Exposure to tobacco smoke outside home	1.3	1.7	3.1	0.4	-1.8	1.8	0.8
Comparative body size at age 10	0.1	0.3	1.1	1.1	0.1	0.0	0.3
Number of full brothers	1.8	2.3	3.3	-0.9	-1.6	1.6	1.8
Worry too long after embarrassment	3.3	5.6	8.9	-0.3	3.0	-2.9	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.2	-0.2	0.2	-0.4
Wheeze or whistling in the chest in last year	1.1	1.9	2.8	-1.4	-1.6	1.7	0.6
Number of children fathered	1.4	1.6	3.4	1.9	-0.9	0.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.2	5.8	-1.4	-2.4	2.3	2.0
Age at first live birth	0.1	0.1	0.2	-0.3	-0.4	0.5	-0.3
Pulse wave peak to peak time	0.0	0.0	0.1	0.2	-0.1	0.2	-0.1
Health satisfaction	0.5	0.6	0.9	-0.0	-0.9	0.9	0.9
Shortness of breath walking on level ground	0.0	0.1	0.1	0.2	-0.1	0.1	0.4
Qualifications: College or University degree	0.7	2.3	3.2	1.1	1.8	-1.5	-1.6
Eye problems/disorders: None of the above	0.8	0.9	2.0	-0.7	-0.8	0.8	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.8	1.7	-0.2	0.3	0.2
Emphysema/chronic bronchitis	0.4	0.4	0.8	0.3	-0.9	0.9	0.1
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	-0.0	1.0	-1.0	-1.1
Neck or shoulder pain in last month	5.6	7.9	10.7	-1.9	-3.2	3.3	2.7
Medication: Blood pressure	2.1	3.7	6.4	0.5	-2.5	2.3	1.7
Angina (self-reported)	1.5	2.0	2.4	1.1	-1.5	1.4	1.6
Migraine (self-reported)	0.2	0.3	0.6	0.3	-0.8	0.7	-0.0
Medication: Ibuprofen	0.5	0.5	0.9	1.0	-0.7	0.8	0.3
Medication: Allopurinol	4.6	6.2	9.4	-0.4	-3.0	3.1	2.4
Medication: Omeprazole	0.1	0.1	0.3	-0.2	-0.1	-0.1	0.5
Medication: Seretide 50 evohaler	0.5	0.6	1.1	-0.3	-1.0	1.1	0.2
Mean time to correctly identify matches	0.7	1.4	2.1	0.2	1.5	-1.4	-1.2
Heart disease (mother)	0.7	0.9	3.3	-1.8	-0.3	0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.4	0.6	0.7	-0.6	-0.6
Whole body fat mass	0.8	3.3	4.7	-0.8	-2.0	2.0	2.2
Leg fat mass (right)	1.4	5.3	7.0	-0.8	-2.6	2.6	2.6
Arm predicted mass (right)	0.0	0.2	0.5	0.7	-0.3	0.2	-0.1
Pulse rate, automated reading	0.2	0.8	2.9	-1.7	-0.3	0.2	0.0
Alcohol intake frequency.	0.1	0.1	0.4	-0.2	0.0	-0.3	-0.7
Comparative height size at age 10	1.3	7.4	10.8	2.3	2.6	-2.5	-3.3
Number of full sisters	0.8	1.0	2.0	-0.3	-1.4	1.3	0.5
Suffer from ‘nerves’	1.2	1.9	4.7	-2.2	-0.9	0.7	1.3
Overall health rating	2.2	4.7	5.6	-1.9	-2.4	2.3	2.1
Chest pain or discomfort	0.1	0.1	0.4	-0.7	-0.1	0.2	-0.2
Had major operations	2.9	3.4	4.9	0.3	-2.1	2.2	2.0
Age at last live birth	1.4	2.0	2.3	-1.4	-1.4	1.5	1.3
Family relationship satisfaction	1.2	1.4	2.3	0.0	1.5	-1.4	-1.2
Leg pain on walking	0.4	0.5	0.6	-0.6	-0.8	0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.2	-1.3	-1.3	1.1	1.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	0.1	-0.4	0.3	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	-1.1	0.6	-0.6	-0.2
Medication: Aspirin	1.3	1.8	2.7	0.7	-1.7	1.6	1.2
Supplements: Vitamin C	1.6	1.8	2.7	0.2	-1.6	1.7	1.4
Knee pain experienced in last month	0.6	0.9	1.4	-0.4	-1.0	0.9	1.2
Hypertension (Self-reported)	0.8	2.2	2.9	0.8	-1.7	1.6	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.8	1.1	2.1	-2.2	-1.1
Illnesses of father: Heart disease	1.2	1.6	2.5	-0.1	-1.6	1.4	1.4
Illnesses of siblings: Diabetes	1.1	1.4	2.1	-0.2	-1.4	1.4	1.2
Smoking status: Previous	1.9	2.9	4.4	-0.3	-2.0	2.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.3	0.7	1.0	-1.2	-1.5
Whole body fat-free mass	0.0	0.1	0.5	0.7	-0.0	-0.1	-0.1
Leg fat-free mass (right)	0.0	0.1	0.2	0.4	0.1	-0.2	-0.1
Arm fat percentage (left)	2.0	7.9	13.1	-1.7	-2.8	2.8	3.6
Average weekly red wine intake	0.2	0.3	0.7	-0.7	-0.0	0.3	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.5	0.1	-0.0	0.5
Mood swings	0.7	1.3	2.0	-0.5	1.2	-1.2	-1.4
Loneliness, isolation	0.2	0.2	0.3	-0.5	-0.5	0.4	0.5
Long-standing illness, disability or infirmity	4.3	6.6	7.7	-2.1	-2.8	2.6	2.8
Ever had bowel cancer screening	1.4	1.6	2.5	-0.5	-1.6	1.5	1.2
Diabetes diagnosed by doctor	2.9	4.7	6.5	1.3	-2.5	2.5	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.3	-1.8	-0.6	0.6	1.3
Friendships satisfaction	2.6	3.3	5.0	1.4	2.2	-2.1	-1.4
Qualifications: nursing, teaching	1.2	1.9	3.8	0.0	-1.3	1.4	1.9
Commuting to job workplace: Walk	1.5	1.7	3.8	-1.9	-0.8	1.0	1.1
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.5	-0.2	0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.9	-1.0	-1.2	1.4	0.7
Medication for cholesterol	2.1	3.2	5.5	0.6	1.9	-1.9	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.0	0.9	1.0	-0.9	-0.8
Back pain experienced in last month	2.5	3.6	5.1	-1.4	-2.3	2.2	1.6
Mineral and other dietary supplements	1.7	2.2	3.1	-0.8	1.8	-1.8	-1.5
Breast cancer (self-reported)	2.4	2.8	4.3	0.8	-2.1	1.9	1.6
Asthma (self-reported)	0.2	0.3	1.2	-0.0	0.3	-0.2	-1.1
Osteoporosis (self-reported)	0.5	0.6	1.8	1.4	-0.3	0.3	-0.6
Osteoarthritis (self-reported)	3.1	4.0	6.1	-2.5	-1.7	1.8	1.9
Medication: Aspirin	1.4	1.8	3.0	0.0	-1.7	1.6	1.2
Medication: Gliclazide	1.4	1.6	2.2	-0.0	-1.4	1.5	1.4
Illnesses of father: None of the above (group 1)	2.3	2.9	4.0	1.0	1.8	-1.8	-2.0
Smoking status: Current	0.3	0.4	1.0	0.3	0.5	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.2	0.2	-0.2	0.8
Whole body water mass	0.0	0.1	0.4	0.7	-0.0	-0.0	-0.1
Leg predicted mass (right)	0.0	0.1	0.2	0.4	0.1	-0.2	-0.0
Arm fat mass (left)	1.3	5.4	8.5	-1.2	-2.4	2.4	2.9
Number of self-reported non-cancer illnesses	2.5	4.4	7.0	0.2	-2.6	2.5	2.1
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-1.0	-0.3	0.5	0.5
Miserableness	0.0	0.0	0.1	0.1	-0.2	0.0	-0.3
Guilty feelings	1.6	2.4	3.9	-1.0	2.0	-1.8	-1.3
Wears glasses or contact lenses	2.9	3.3	5.7	-0.1	-2.3	2.4	1.5
Ever taken oral contraceptive pill	0.3	0.3	1.2	1.1	-0.2	0.3	0.3
Hearing aid user	0.6	0.6	1.7	-1.3	-0.5	0.4	0.7
Mother’s age at death	1.3	1.6	3.2	-1.8	-1.1	1.2	0.8
Financial situation satisfaction	0.4	0.4	0.9	-0.9	-0.2	0.2	0.9
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.4	-0.0	-1.6	1.4	1.4
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.2	-0.3	0.3	-0.6
Eye problems/disorders: Glaucoma	1.8	2.2	2.9	0.9	-1.6	1.6	1.7
Medication: Blood pressure	0.8	1.6	2.8	-0.2	-1.3	1.4	1.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.0	0.2	-1.4	1.3	1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	0.8	0.7	-0.9	0.9	0.6
High cholesterol (Self-reported)	1.7	3.0	11.5	3.4	-0.5	0.5	0.4
Medication: Bendroflumethiazide	1.7	2.6	3.7	0.2	-1.8	1.9	1.9
Medication: Paracetamol	3.5	5.5	6.3	-2.0	-2.5	2.5	2.3
Medication: Lisinopril	0.8	1.1	2.6	1.6	0.3	-0.6	-1.0
Medication: Atorvastatin	1.2	1.5	6.2	2.5	0.1	-0.1	0.1
Illnesses of father: High blood pressure	2.2	2.7	4.1	-2.0	-1.1	1.2	2.0
Alcohol drinker status: Never	2.5	2.9	4.3	1.2	2.0	-2.1	-1.5
Ever smoked	0.7	1.2	2.0	-0.3	-1.4	1.4	0.8
Basal metabolic rate	0.0	0.1	0.2	0.5	-0.3	0.2	0.2
Leg fat percentage (left)	2.2	7.9	11.0	-1.1	-3.1	3.1	3.3
Arm fat-free mass (left)	0.0	0.1	0.2	0.5	-0.3	0.3	0.1
Number of operations (self-reported)	4.9	7.3	10.4	0.7	-3.1	3.2	2.9
Average weekly beer plus cider intake	0.2	0.2	0.7	0.9	-0.4	0.3	-0.2
Irritability	0.3	0.6	1.0	-0.5	0.7	-0.7	-1.0
Risk taking	2.8	4.2	6.2	-0.9	-2.5	2.5	1.9
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.4	1.2	-1.0	1.2	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.2	-0.1	0.0	0.4
Age started oral contraceptive pill	0.4	0.5	1.4	0.0	0.7	-0.5	-1.2
Diastolic blood pressure, automated reading	0.8	2.6	4.9	0.2	-1.7	1.7	2.2
Ever depressed for a whole week	0.1	0.2	0.3	0.5	0.3	-0.4	-0.5
Unable to work because of sickness or disability	0.0	0.0	0.1	0.1	-0.0	-0.2	-0.0
Commuting to job workplace: Cycle	0.7	0.9	2.2	-1.5	-0.3	0.7	0.8
Myopia	1.0	1.5	2.1	-0.9	-1.3	1.4	1.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.1	-0.6	1.8	-1.6	-1.6
Cholesterol lowering medication	0.7	1.1	1.8	1.3	-0.8	0.7	1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	-0.2	-0.2	0.1	0.8
Pain experienced in last month	5.2	8.6	12.0	0.9	3.5	-3.5	-3.1
Supplements: Calcium	1.1	1.2	3.7	1.9	-0.7	0.7	-0.0
Basal cell carcinoma (self-reported)	0.7	0.8	1.2	1.1	0.9	-0.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	1.3	-0.4	0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.0	-0.2	-1.0	0.8	1.4
Heart disease (siblings)	1.2	1.5	2.6	-0.8	-1.2	1.2	1.6
Alcohol drinker status: Previous	2.1	2.4	4.0	-0.7	-2.0	2.0	1.2
Pack years of smoking	0.2	0.3	0.9	0.4	-0.3	0.0	-1.0
Impedance of whole body	0.9	4.4	6.7	0.8	2.3	-2.2	-2.6
Leg fat mass (left)	1.4	5.5	7.6	-0.7	-2.6	2.6	2.8
Arm predicted mass (left)	0.0	0.2	0.3	0.4	-0.5	0.5	0.2