[Hub]/) : Traits : Hair Pigment :

chr11:76,602,665-78,979,645

Best TWAS P=1.33e-107 · Best GWAS P=6.47e-110 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex INTS4 0.10 0.03 enet 16 0.07 2.3e-09 0.57 7.9 3.7e-15 -0.28 0.98 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex KCTD21 0.30 0.26 bslmm 354 0.27 7.6e-33 -4.12 5.9 3.6e-09 -0.20 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex NARS2 0.44 0.57 bslmm 502 0.56 2.1e-81 -16.91 16.8 1.6e-63 -0.69 1.00 0.00 FALSE
4 CommonMind Brain Pre-frontal Cortex USP35 0.06 0.05 blup 363 0.04 1.6e-05 -16.95 -17.4 1.5e-67 0.67 0.62 0.10 FALSE
5 GTEx Adipose Subcutaneous NARS2 0.19 0.12 lasso 5 0.09 3.6e-08 -16.91 17.3 5.7e-67 -0.73 0.88 0.12 FALSE
6 GTEx Adipose Visceral Omentum ALG8 0.11 0.01 enet 8 0.02 3.7e-02 -20.46 -17.3 4.0e-67 0.73 0.19 0.20 FALSE
7 GTEx Adrenal Gland NARS2 0.43 0.09 enet 47 0.22 2.6e-08 -16.84 11.3 1.1e-29 -0.44 0.53 0.27 FALSE
8 GTEx Artery Aorta GAB2 0.10 0.02 lasso 4 0.02 1.7e-02 -21.31 18.3 1.1e-74 -0.76 0.04 0.81 FALSE
9 GTEx Artery Aorta NARS2 0.26 0.29 lasso 2 0.28 1.7e-15 -16.91 16.9 2.4e-64 -0.70 1.00 0.00 FALSE
10 GTEx Artery Aorta RP11-91P24.7 0.27 0.26 lasso 10 0.27 2.7e-15 4.67 -5.4 8.3e-08 0.00 1.00 0.00 FALSE
11 GTEx Artery Coronary NARS2 0.19 0.20 lasso 2 0.17 2.7e-06 -16.91 16.9 2.6e-64 -0.70 0.66 0.25 FALSE
12 GTEx Artery Tibial GAB2 0.06 0.00 lasso 2 0.01 2.4e-02 -21.38 21.5 6.0e-103 -0.90 0.13 0.51 FALSE
13 GTEx Artery Tibial NARS2 0.18 0.20 lasso 2 0.19 5.9e-15 -16.91 16.9 2.2e-64 -0.70 1.00 0.00 FALSE
14 GTEx Artery Tibial INTS4 0.09 0.03 enet 25 0.06 1.6e-05 4.48 6.5 1.0e-10 -0.06 0.98 0.00 FALSE
15 GTEx Artery Tibial AQP11 0.06 0.05 enet 20 0.04 5.2e-04 4.39 -5.4 7.4e-08 0.03 0.53 0.03 FALSE
16 GTEx Brain Cerebellar Hemisphere USP35 0.19 0.07 enet 13 0.09 2.5e-03 -20.46 -21.4 2.1e-101 0.87 0.20 0.26 TRUE
17 GTEx Brain Cerebellar Hemisphere NARS2 0.17 0.10 lasso 6 0.10 1.5e-03 -16.88 19.0 7.8e-81 -0.76 0.18 0.52 FALSE
18 GTEx Brain Cerebellar Hemisphere RP11-91P24.6 0.16 0.01 enet 38 0.02 8.4e-02 4.37 -5.3 1.2e-07 0.01 0.17 0.10 FALSE
19 GTEx Brain Nucleus accumbens basal ganglia AAMDC 0.15 0.02 lasso 6 0.05 1.7e-02 3.58 -6.4 1.9e-10 0.04 0.14 0.05 TRUE
20 GTEx Breast Mammary Tissue INTS4 0.10 0.02 enet 21 0.00 2.6e-01 4.43 9.0 2.8e-19 -0.23 0.28 0.04 TRUE
21 GTEx Breast Mammary Tissue (Male) INTS4 0.11 0.03 lasso 3 0.01 1.6e-01 -2.38 12.9 8.3e-38 -0.60 0.04 0.18 FALSE
22 GTEx Cells Transformed fibroblasts AAMDC 0.10 0.09 lasso 8 0.07 3.3e-06 4.67 -5.1 3.0e-07 0.00 0.92 0.00 FALSE
23 GTEx Cells Transformed fibroblasts NARS2 0.23 0.10 enet 27 0.09 2.1e-07 -16.91 9.9 5.0e-23 -0.35 0.90 0.01 TRUE
24 GTEx Cells Transformed fibroblasts RP11-91P24.6 0.08 0.06 lasso 7 0.05 1.5e-04 4.78 -5.4 5.8e-08 -0.02 0.54 0.02 FALSE
25 GTEx Colon Sigmoid RP11-91P24.6 0.11 0.13 lasso 3 0.10 1.5e-04 4.78 -5.1 2.7e-07 -0.03 0.27 0.04 FALSE
26 GTEx Colon Transverse NARS2 0.18 -0.01 lasso 8 0.00 2.0e-01 0.25 9.4 5.7e-21 -0.39 0.10 0.15 FALSE
27 GTEx Colon Transverse INTS4 0.14 0.01 enet 13 0.06 9.2e-04 -6.02 6.0 2.2e-09 -0.13 0.24 0.03 FALSE
28 GTEx Esophagus Gastroesophageal Junction NARS2 0.15 0.22 lasso 5 0.20 9.6e-08 -16.84 16.9 4.4e-64 -0.70 0.97 0.02 FALSE
29 GTEx Esophagus Gastroesophageal Junction KCTD21-AS1 0.17 0.10 enet 11 0.08 9.7e-04 -2.49 7.1 1.7e-12 -0.23 0.33 0.03 FALSE
30 GTEx Esophagus Gastroesophageal Junction RP11-452H21.1 0.19 0.19 lasso 5 0.20 7.7e-08 -16.85 16.8 4.2e-63 -0.71 0.72 0.18 FALSE
31 GTEx Esophagus Mucosa INTS4 0.23 0.13 lasso 13 0.19 1.4e-12 -6.17 6.0 1.8e-09 -0.13 1.00 0.00 FALSE
32 GTEx Esophagus Muscularis GAB2 0.05 0.04 lasso 7 0.04 1.8e-03 -18.95 20.6 1.6e-94 -0.89 0.13 0.78 FALSE
33 GTEx Esophagus Muscularis NARS2 0.25 0.19 lasso 3 0.17 8.7e-11 -16.91 16.9 4.6e-64 -0.70 1.00 0.00 FALSE
34 GTEx Esophagus Muscularis RP11-452H21.1 0.10 0.08 lasso 6 0.07 2.6e-05 -16.88 16.7 1.1e-62 -0.69 0.80 0.08 FALSE
35 GTEx Heart Left Ventricle INTS4 0.14 0.09 lasso 8 0.07 8.6e-05 -6.17 6.2 5.1e-10 -0.15 0.78 0.01 FALSE
36 GTEx Liver GAB2 0.17 -0.01 enet 20 -0.01 5.6e-01 -20.74 -16.7 2.3e-62 0.74 0.04 0.60 FALSE
37 GTEx Lung NARS2 0.21 0.20 lasso 3 0.21 3.5e-16 -16.84 16.9 5.4e-64 -0.70 1.00 0.00 FALSE
38 GTEx Muscle Skeletal NARS2 0.19 0.05 lasso 2 0.04 1.1e-04 -16.91 17.0 5.2e-65 -0.69 0.29 0.03 FALSE
39 GTEx Muscle Skeletal INTS4 0.19 0.13 lasso 12 0.14 5.5e-14 -6.02 8.1 6.1e-16 -0.14 1.00 0.00 TRUE
40 GTEx Muscle Skeletal ALG8 0.09 0.00 enet 25 0.02 9.5e-03 3.76 5.4 8.2e-08 -0.19 0.12 0.07 FALSE
41 GTEx Nerve Tibial NARS2 0.20 0.18 lasso 3 0.18 2.0e-12 -16.91 16.9 1.9e-64 -0.70 1.00 0.00 FALSE
42 GTEx Ovary AAMDC 0.17 0.10 enet 27 0.15 1.6e-04 3.69 -10.2 2.7e-24 0.24 0.14 0.06 FALSE
43 GTEx Pituitary KCTD21-AS1 0.34 0.16 enet 18 0.15 1.6e-04 -2.32 7.4 1.3e-13 -0.26 0.22 0.08 TRUE
44 GTEx Skin Not Sun Exposed Suprapubic RP11-7I15.3 0.07 0.01 lasso 3 0.02 3.5e-02 -21.27 -19.5 2.0e-84 0.79 0.14 0.45 FALSE
45 GTEx Skin Sun Exposed Lower leg GAB2 0.06 0.01 enet 26 0.03 2.2e-03 -21.31 16.0 6.6e-58 -0.71 0.12 0.83 FALSE
46 GTEx Skin Sun Exposed Lower leg RSF1 0.06 0.00 enet 16 0.00 3.4e-01 4.48 -6.0 2.4e-09 0.05 0.24 0.05 FALSE
47 GTEx Skin Sun Exposed Lower leg INTS4 0.14 0.03 lasso 5 0.04 3.9e-04 4.67 5.2 2.5e-07 0.00 0.67 0.01 FALSE
48 GTEx Stomach NARS2 0.27 0.05 lasso 8 0.06 6.1e-04 -16.83 12.7 3.7e-37 -0.57 0.21 0.05 FALSE
49 GTEx Stomach AP000580.1 0.10 0.00 enet 23 0.00 2.3e-01 1.32 -7.2 5.8e-13 0.43 0.15 0.32 FALSE
50 GTEx Testis USP35 0.07 0.06 lasso 2 0.07 6.4e-04 -21.38 -21.4 1.4e-101 0.89 0.15 0.72 FALSE
51 GTEx Thyroid NARS2 0.30 0.30 lasso 4 0.32 1.4e-24 -16.84 17.0 5.8e-65 -0.69 1.00 0.00 FALSE
52 GTEx Thyroid RP11-452H21.1 0.13 0.06 lasso 4 0.03 3.6e-03 -16.81 16.7 7.3e-63 -0.69 0.79 0.02 FALSE
53 GTEx Whole Blood INTS4 0.05 0.03 lasso 4 0.01 4.5e-02 5.62 5.4 5.2e-08 -0.14 0.16 0.03 FALSE
54 METSIM Adipose NARS2 0.10 0.06 bslmm 487 0.06 7.2e-10 -16.83 8.9 5.6e-19 -0.32 1.00 0.00 FALSE
55 METSIM Adipose USP35 0.05 0.05 lasso 11 0.04 3.0e-06 -21.38 -21.4 6.7e-102 0.89 0.99 0.01 FALSE
56 NTR Blood INTS4 0.04 0.01 enet 18 0.01 9.7e-06 -6.17 5.9 4.2e-09 -0.17 1.00 0.00 TRUE
57 ROSMAP Brain Pre-frontal Cortex GAB2 0.05 0.00 blup 435 0.02 8.0e-04 -18.87 19.3 4.5e-83 -0.81 0.10 0.86 FALSE
58 ROSMAP Brain Pre-frontal Cortex AAMDC 0.13 0.16 enet 24 0.18 2.8e-22 4.67 -5.8 7.5e-09 0.01 1.00 0.00 FALSE
59 ROSMAP Brain Pre-frontal Cortex NARS2 0.17 0.17 lasso 2 0.17 1.8e-21 -16.91 16.9 2.3e-64 -0.70 1.00 0.00 FALSE
60 YFS Blood INTS4 0.09 0.09 lasso 3 0.10 2.0e-30 -6.02 6.6 3.4e-11 -0.15 1.00 0.00 FALSE
61 The Cancer Genome Atlas Bladder Urothelial Carcinoma INTS4 0.10 0.08 lasso 2 0.08 1.7e-07 -6.02 6.6 5.2e-11 -0.13 0.01 0.99 FALSE
62 The Cancer Genome Atlas Breast Invasive Carcinoma C11orf67 0.02 0.02 blup 60 0.01 9.2e-04 4.75 -6.2 6.6e-10 0.04 0.27 0.39 FALSE
63 The Cancer Genome Atlas Breast Invasive Carcinoma INTS4 0.06 0.02 blup 72 0.06 4.1e-12 4.78 6.4 1.7e-10 -0.06 0.07 0.93 FALSE
64 The Cancer Genome Atlas Breast Invasive Carcinoma NARS2 0.12 0.05 lasso 2 0.05 2.0e-10 -16.77 16.8 1.7e-63 -0.69 1.00 0.00 FALSE
65 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma INTS4 0.21 0.09 blup 73 0.10 1.4e-05 -6.02 6.9 6.3e-12 -0.13 0.01 0.98 FALSE
66 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma NARS2 0.09 0.04 blup 60 0.04 5.9e-03 -16.83 17.5 1.4e-68 -0.73 0.10 0.20 FALSE
67 The Cancer Genome Atlas Glioblastoma Multiforme GAB2 0.10 0.07 blup 100 0.09 8.8e-04 -21.73 21.9 1.5e-106 -0.93 0.05 0.62 FALSE
68 The Cancer Genome Atlas Glioblastoma Multiforme NARS2 0.19 0.14 lasso 2 0.13 9.8e-05 -16.81 16.2 2.5e-59 -0.68 0.10 0.52 FALSE
69 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma AQP11 0.04 0.01 blup 39 0.02 9.1e-04 4.47 5.3 9.3e-08 0.01 0.09 0.34 FALSE
70 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C11orf67 0.03 0.01 enet 11 0.02 1.8e-03 4.91 -5.9 4.3e-09 0.01 0.04 0.08 FALSE
71 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma INTS4 0.15 0.10 lasso 2 0.09 4.6e-10 -6.02 5.9 4.3e-09 -0.15 0.01 0.99 FALSE
72 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C11orf67 0.09 0.08 lasso 2 0.07 1.8e-08 4.75 -5.6 1.7e-08 0.00 0.94 0.05 FALSE
73 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma INTS4 0.12 0.10 blup 72 0.10 3.5e-11 -6.13 6.5 6.8e-11 -0.10 0.01 0.99 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NARS2 0.14 0.06 lasso 2 0.06 2.9e-07 -16.81 16.9 5.3e-64 -0.70 0.99 0.01 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma INTS4 0.28 0.18 enet 22 0.17 7.2e-10 -6.17 6.2 8.0e-10 -0.16 0.01 0.99 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma C11orf67 0.09 0.06 blup 60 0.08 4.9e-09 4.78 -6.0 2.4e-09 0.01 0.96 0.04 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma NARS2 0.24 0.13 lasso 2 0.13 3.1e-14 -16.83 16.8 1.6e-63 -0.69 1.00 0.00 FALSE
78 The Cancer Genome Atlas Liver Hepatocellular Carcinoma INTS4 0.14 0.08 blup 73 0.08 1.9e-04 -6.46 6.0 2.5e-09 -0.15 0.00 0.98 FALSE
79 The Cancer Genome Atlas Lung Adenocarcinoma NARS2 0.17 0.09 enet 10 0.10 1.6e-11 -16.81 14.2 8.6e-46 -0.61 1.00 0.00 FALSE
80 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C11orf67 0.04 0.01 blup 60 0.01 1.3e-02 4.78 -5.6 1.7e-08 0.02 0.05 0.06 FALSE
81 The Cancer Genome Atlas Lung Squamous Cell Carcinoma INTS4 0.11 0.10 blup 72 0.11 4.1e-12 -6.02 5.4 6.9e-08 -0.12 0.01 0.99 FALSE
82 The Cancer Genome Atlas Lung Squamous Cell Carcinoma NARS2 0.11 0.04 lasso 3 0.04 9.9e-06 -16.85 16.9 3.0e-64 -0.70 0.83 0.05 FALSE
83 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma INTS4 0.11 0.11 lasso 2 0.10 3.3e-07 -6.17 6.3 2.9e-10 -0.16 0.01 0.99 TRUE
84 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma NARS2 0.11 0.01 enet 10 0.04 1.2e-03 -16.85 13.8 2.0e-43 -0.61 0.03 0.20 FALSE
85 The Cancer Genome Atlas Pancreatic Adenocarcinoma C11orf67 0.08 0.09 lasso 9 0.07 1.0e-03 5.36 -5.2 1.9e-07 0.03 0.06 0.13 FALSE
86 The Cancer Genome Atlas Pancreatic Adenocarcinoma INTS4 0.16 0.10 lasso 3 0.08 2.9e-04 -6.02 6.0 2.0e-09 -0.15 0.01 0.94 FALSE
87 The Cancer Genome Atlas Pancreatic Adenocarcinoma NARS2 0.20 0.21 lasso 9 0.20 5.6e-09 -16.77 16.8 1.2e-63 -0.69 0.62 0.37 FALSE
88 The Cancer Genome Atlas Prostate Adenocarcinoma CLNS1A 0.04 0.02 blup 41 0.03 3.0e-04 4.43 5.7 1.0e-08 -0.02 0.14 0.37 FALSE
89 The Cancer Genome Atlas Prostate Adenocarcinoma GAB2 0.06 0.06 blup 100 0.07 7.8e-08 -21.31 22.0 1.8e-107 -0.94 0.04 0.96 TRUE
90 The Cancer Genome Atlas Prostate Adenocarcinoma INTS4 0.17 0.15 lasso 6 0.17 3.3e-17 -6.02 7.1 1.2e-12 -0.12 0.01 0.99 FALSE
91 The Cancer Genome Atlas Prostate Adenocarcinoma KCTD21 0.03 0.00 blup 51 0.01 7.2e-02 -20.60 17.6 2.7e-69 -0.77 0.01 0.63 TRUE
92 The Cancer Genome Atlas Prostate Adenocarcinoma NARS2 0.30 0.19 lasso 2 0.17 2.6e-17 -16.84 16.8 1.2e-63 -0.70 1.00 0.00 FALSE
93 The Cancer Genome Atlas Prostate Adenocarcinoma USP35 0.12 0.02 blup 55 0.02 1.5e-03 -4.12 -10.8 3.8e-27 0.31 0.09 0.10 FALSE
94 The Cancer Genome Atlas Soft Tissue Sarcoma NARS2 0.11 0.05 enet 7 0.06 2.0e-04 -16.81 15.4 2.0e-53 -0.62 0.13 0.52 FALSE
95 The Cancer Genome Atlas Stomach Adenocarcinoma GAB2 0.04 0.04 blup 100 0.04 1.4e-03 -20.46 22.0 1.3e-107 -0.91 0.05 0.88 FALSE
96 The Cancer Genome Atlas Stomach Adenocarcinoma INTS4 0.12 0.10 lasso 4 0.09 3.2e-07 -6.17 6.1 8.8e-10 -0.15 0.01 0.99 FALSE
97 The Cancer Genome Atlas Testicular Germ Cell Tumors INTS4 0.20 0.03 blup 72 0.07 2.1e-03 -2.95 6.2 5.6e-10 -0.12 0.02 0.32 FALSE
98 The Cancer Genome Atlas Thyroid Carcinoma C11orf67 0.11 0.09 blup 60 0.12 7.8e-12 4.72 -5.9 3.7e-09 0.00 0.96 0.04 FALSE
99 The Cancer Genome Atlas Thyroid Carcinoma INTS4 0.20 0.20 enet 7 0.23 6.8e-22 -6.17 7.1 1.7e-12 -0.11 0.01 0.99 FALSE
100 The Cancer Genome Atlas Thyroid Carcinoma KCTD21 0.05 0.03 blup 51 0.03 1.2e-03 -3.91 16.2 1.1e-58 -0.56 0.06 0.39 FALSE
101 The Cancer Genome Atlas Thyroid Carcinoma NARS2 0.27 0.27 lasso 4 0.27 1.9e-26 -16.77 17.1 1.1e-65 -0.70 1.00 0.00 FALSE