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chr11:76,602,665-78,979,645

Best TWAS P=1.33e-107 · Best GWAS P=6.47e-110 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INTS4	0.10	0.03	enet	16	0.07	2.3e-09	0.57	7.9	3.7e-15	-0.28	0.98	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KCTD21	0.30	0.26	bslmm	354	0.27	7.6e-33	-4.12	5.9	3.6e-09	-0.20	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NARS2	0.44	0.57	bslmm	502	0.56	2.1e-81	-16.91	16.8	1.6e-63	-0.69	1.00	0.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	USP35	0.06	0.05	blup	363	0.04	1.6e-05	-16.95	-17.4	1.5e-67	0.67	0.62	0.10	FALSE
5	GTEx	Adipose Subcutaneous	NARS2	0.19	0.12	lasso	5	0.09	3.6e-08	-16.91	17.3	5.7e-67	-0.73	0.88	0.12	FALSE
6	GTEx	Adipose Visceral Omentum	ALG8	0.11	0.01	enet	8	0.02	3.7e-02	-20.46	-17.3	4.0e-67	0.73	0.19	0.20	FALSE
7	GTEx	Adrenal Gland	NARS2	0.43	0.09	enet	47	0.22	2.6e-08	-16.84	11.3	1.1e-29	-0.44	0.53	0.27	FALSE
8	GTEx	Artery Aorta	GAB2	0.10	0.02	lasso	4	0.02	1.7e-02	-21.31	18.3	1.1e-74	-0.76	0.04	0.81	FALSE
9	GTEx	Artery Aorta	NARS2	0.26	0.29	lasso	2	0.28	1.7e-15	-16.91	16.9	2.4e-64	-0.70	1.00	0.00	FALSE
10	GTEx	Artery Aorta	RP11-91P24.7	0.27	0.26	lasso	10	0.27	2.7e-15	4.67	-5.4	8.3e-08	0.00	1.00	0.00	FALSE
11	GTEx	Artery Coronary	NARS2	0.19	0.20	lasso	2	0.17	2.7e-06	-16.91	16.9	2.6e-64	-0.70	0.66	0.25	FALSE
12	GTEx	Artery Tibial	GAB2	0.06	0.00	lasso	2	0.01	2.4e-02	-21.38	21.5	6.0e-103	-0.90	0.13	0.51	FALSE
13	GTEx	Artery Tibial	NARS2	0.18	0.20	lasso	2	0.19	5.9e-15	-16.91	16.9	2.2e-64	-0.70	1.00	0.00	FALSE
14	GTEx	Artery Tibial	INTS4	0.09	0.03	enet	25	0.06	1.6e-05	4.48	6.5	1.0e-10	-0.06	0.98	0.00	FALSE
15	GTEx	Artery Tibial	AQP11	0.06	0.05	enet	20	0.04	5.2e-04	4.39	-5.4	7.4e-08	0.03	0.53	0.03	FALSE
16	GTEx	Brain Cerebellar Hemisphere	USP35	0.19	0.07	enet	13	0.09	2.5e-03	-20.46	-21.4	2.1e-101	0.87	0.20	0.26	TRUE
17	GTEx	Brain Cerebellar Hemisphere	NARS2	0.17	0.10	lasso	6	0.10	1.5e-03	-16.88	19.0	7.8e-81	-0.76	0.18	0.52	FALSE
18	GTEx	Brain Cerebellar Hemisphere	RP11-91P24.6	0.16	0.01	enet	38	0.02	8.4e-02	4.37	-5.3	1.2e-07	0.01	0.17	0.10	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	AAMDC	0.15	0.02	lasso	6	0.05	1.7e-02	3.58	-6.4	1.9e-10	0.04	0.14	0.05	TRUE
20	GTEx	Breast Mammary Tissue	INTS4	0.10	0.02	enet	21	0.00	2.6e-01	4.43	9.0	2.8e-19	-0.23	0.28	0.04	TRUE
21	GTEx	Breast Mammary Tissue (Male)	INTS4	0.11	0.03	lasso	3	0.01	1.6e-01	-2.38	12.9	8.3e-38	-0.60	0.04	0.18	FALSE
22	GTEx	Cells Transformed fibroblasts	AAMDC	0.10	0.09	lasso	8	0.07	3.3e-06	4.67	-5.1	3.0e-07	0.00	0.92	0.00	FALSE
23	GTEx	Cells Transformed fibroblasts	NARS2	0.23	0.10	enet	27	0.09	2.1e-07	-16.91	9.9	5.0e-23	-0.35	0.90	0.01	TRUE
24	GTEx	Cells Transformed fibroblasts	RP11-91P24.6	0.08	0.06	lasso	7	0.05	1.5e-04	4.78	-5.4	5.8e-08	-0.02	0.54	0.02	FALSE
25	GTEx	Colon Sigmoid	RP11-91P24.6	0.11	0.13	lasso	3	0.10	1.5e-04	4.78	-5.1	2.7e-07	-0.03	0.27	0.04	FALSE
26	GTEx	Colon Transverse	NARS2	0.18	-0.01	lasso	8	0.00	2.0e-01	0.25	9.4	5.7e-21	-0.39	0.10	0.15	FALSE
27	GTEx	Colon Transverse	INTS4	0.14	0.01	enet	13	0.06	9.2e-04	-6.02	6.0	2.2e-09	-0.13	0.24	0.03	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	NARS2	0.15	0.22	lasso	5	0.20	9.6e-08	-16.84	16.9	4.4e-64	-0.70	0.97	0.02	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	KCTD21-AS1	0.17	0.10	enet	11	0.08	9.7e-04	-2.49	7.1	1.7e-12	-0.23	0.33	0.03	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	RP11-452H21.1	0.19	0.19	lasso	5	0.20	7.7e-08	-16.85	16.8	4.2e-63	-0.71	0.72	0.18	FALSE
31	GTEx	Esophagus Mucosa	INTS4	0.23	0.13	lasso	13	0.19	1.4e-12	-6.17	6.0	1.8e-09	-0.13	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	GAB2	0.05	0.04	lasso	7	0.04	1.8e-03	-18.95	20.6	1.6e-94	-0.89	0.13	0.78	FALSE
33	GTEx	Esophagus Muscularis	NARS2	0.25	0.19	lasso	3	0.17	8.7e-11	-16.91	16.9	4.6e-64	-0.70	1.00	0.00	FALSE
34	GTEx	Esophagus Muscularis	RP11-452H21.1	0.10	0.08	lasso	6	0.07	2.6e-05	-16.88	16.7	1.1e-62	-0.69	0.80	0.08	FALSE
35	GTEx	Heart Left Ventricle	INTS4	0.14	0.09	lasso	8	0.07	8.6e-05	-6.17	6.2	5.1e-10	-0.15	0.78	0.01	FALSE
36	GTEx	Liver	GAB2	0.17	-0.01	enet	20	-0.01	5.6e-01	-20.74	-16.7	2.3e-62	0.74	0.04	0.60	FALSE
37	GTEx	Lung	NARS2	0.21	0.20	lasso	3	0.21	3.5e-16	-16.84	16.9	5.4e-64	-0.70	1.00	0.00	FALSE
38	GTEx	Muscle Skeletal	NARS2	0.19	0.05	lasso	2	0.04	1.1e-04	-16.91	17.0	5.2e-65	-0.69	0.29	0.03	FALSE
39	GTEx	Muscle Skeletal	INTS4	0.19	0.13	lasso	12	0.14	5.5e-14	-6.02	8.1	6.1e-16	-0.14	1.00	0.00	TRUE
40	GTEx	Muscle Skeletal	ALG8	0.09	0.00	enet	25	0.02	9.5e-03	3.76	5.4	8.2e-08	-0.19	0.12	0.07	FALSE
41	GTEx	Nerve Tibial	NARS2	0.20	0.18	lasso	3	0.18	2.0e-12	-16.91	16.9	1.9e-64	-0.70	1.00	0.00	FALSE
42	GTEx	Ovary	AAMDC	0.17	0.10	enet	27	0.15	1.6e-04	3.69	-10.2	2.7e-24	0.24	0.14	0.06	FALSE
43	GTEx	Pituitary	KCTD21-AS1	0.34	0.16	enet	18	0.15	1.6e-04	-2.32	7.4	1.3e-13	-0.26	0.22	0.08	TRUE
44	GTEx	Skin Not Sun Exposed Suprapubic	RP11-7I15.3	0.07	0.01	lasso	3	0.02	3.5e-02	-21.27	-19.5	2.0e-84	0.79	0.14	0.45	FALSE
45	GTEx	Skin Sun Exposed Lower leg	GAB2	0.06	0.01	enet	26	0.03	2.2e-03	-21.31	16.0	6.6e-58	-0.71	0.12	0.83	FALSE
46	GTEx	Skin Sun Exposed Lower leg	RSF1	0.06	0.00	enet	16	0.00	3.4e-01	4.48	-6.0	2.4e-09	0.05	0.24	0.05	FALSE
47	GTEx	Skin Sun Exposed Lower leg	INTS4	0.14	0.03	lasso	5	0.04	3.9e-04	4.67	5.2	2.5e-07	0.00	0.67	0.01	FALSE
48	GTEx	Stomach	NARS2	0.27	0.05	lasso	8	0.06	6.1e-04	-16.83	12.7	3.7e-37	-0.57	0.21	0.05	FALSE
49	GTEx	Stomach	AP000580.1	0.10	0.00	enet	23	0.00	2.3e-01	1.32	-7.2	5.8e-13	0.43	0.15	0.32	FALSE
50	GTEx	Testis	USP35	0.07	0.06	lasso	2	0.07	6.4e-04	-21.38	-21.4	1.4e-101	0.89	0.15	0.72	FALSE
51	GTEx	Thyroid	NARS2	0.30	0.30	lasso	4	0.32	1.4e-24	-16.84	17.0	5.8e-65	-0.69	1.00	0.00	FALSE
52	GTEx	Thyroid	RP11-452H21.1	0.13	0.06	lasso	4	0.03	3.6e-03	-16.81	16.7	7.3e-63	-0.69	0.79	0.02	FALSE
53	GTEx	Whole Blood	INTS4	0.05	0.03	lasso	4	0.01	4.5e-02	5.62	5.4	5.2e-08	-0.14	0.16	0.03	FALSE
54	METSIM	Adipose	NARS2	0.10	0.06	bslmm	487	0.06	7.2e-10	-16.83	8.9	5.6e-19	-0.32	1.00	0.00	FALSE
55	METSIM	Adipose	USP35	0.05	0.05	lasso	11	0.04	3.0e-06	-21.38	-21.4	6.7e-102	0.89	0.99	0.01	FALSE
56	NTR	Blood	INTS4	0.04	0.01	enet	18	0.01	9.7e-06	-6.17	5.9	4.2e-09	-0.17	1.00	0.00	TRUE
57	ROSMAP	Brain Pre-frontal Cortex	GAB2	0.05	0.00	blup	435	0.02	8.0e-04	-18.87	19.3	4.5e-83	-0.81	0.10	0.86	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	AAMDC	0.13	0.16	enet	24	0.18	2.8e-22	4.67	-5.8	7.5e-09	0.01	1.00	0.00	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	NARS2	0.17	0.17	lasso	2	0.17	1.8e-21	-16.91	16.9	2.3e-64	-0.70	1.00	0.00	FALSE
60	YFS	Blood	INTS4	0.09	0.09	lasso	3	0.10	2.0e-30	-6.02	6.6	3.4e-11	-0.15	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	INTS4	0.10	0.08	lasso	2	0.08	1.7e-07	-6.02	6.6	5.2e-11	-0.13	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf67	0.02	0.02	blup	60	0.01	9.2e-04	4.75	-6.2	6.6e-10	0.04	0.27	0.39	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	INTS4	0.06	0.02	blup	72	0.06	4.1e-12	4.78	6.4	1.7e-10	-0.06	0.07	0.93	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	NARS2	0.12	0.05	lasso	2	0.05	2.0e-10	-16.77	16.8	1.7e-63	-0.69	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INTS4	0.21	0.09	blup	73	0.10	1.4e-05	-6.02	6.9	6.3e-12	-0.13	0.01	0.98	FALSE
66	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NARS2	0.09	0.04	blup	60	0.04	5.9e-03	-16.83	17.5	1.4e-68	-0.73	0.10	0.20	FALSE
67	The Cancer Genome Atlas	Glioblastoma Multiforme	GAB2	0.10	0.07	blup	100	0.09	8.8e-04	-21.73	21.9	1.5e-106	-0.93	0.05	0.62	FALSE
68	The Cancer Genome Atlas	Glioblastoma Multiforme	NARS2	0.19	0.14	lasso	2	0.13	9.8e-05	-16.81	16.2	2.5e-59	-0.68	0.10	0.52	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AQP11	0.04	0.01	blup	39	0.02	9.1e-04	4.47	5.3	9.3e-08	0.01	0.09	0.34	FALSE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C11orf67	0.03	0.01	enet	11	0.02	1.8e-03	4.91	-5.9	4.3e-09	0.01	0.04	0.08	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INTS4	0.15	0.10	lasso	2	0.09	4.6e-10	-6.02	5.9	4.3e-09	-0.15	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C11orf67	0.09	0.08	lasso	2	0.07	1.8e-08	4.75	-5.6	1.7e-08	0.00	0.94	0.05	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	INTS4	0.12	0.10	blup	72	0.10	3.5e-11	-6.13	6.5	6.8e-11	-0.10	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NARS2	0.14	0.06	lasso	2	0.06	2.9e-07	-16.81	16.9	5.3e-64	-0.70	0.99	0.01	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INTS4	0.28	0.18	enet	22	0.17	7.2e-10	-6.17	6.2	8.0e-10	-0.16	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf67	0.09	0.06	blup	60	0.08	4.9e-09	4.78	-6.0	2.4e-09	0.01	0.96	0.04	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	NARS2	0.24	0.13	lasso	2	0.13	3.1e-14	-16.83	16.8	1.6e-63	-0.69	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	INTS4	0.14	0.08	blup	73	0.08	1.9e-04	-6.46	6.0	2.5e-09	-0.15	0.00	0.98	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	NARS2	0.17	0.09	enet	10	0.10	1.6e-11	-16.81	14.2	8.6e-46	-0.61	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf67	0.04	0.01	blup	60	0.01	1.3e-02	4.78	-5.6	1.7e-08	0.02	0.05	0.06	FALSE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	INTS4	0.11	0.10	blup	72	0.11	4.1e-12	-6.02	5.4	6.9e-08	-0.12	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NARS2	0.11	0.04	lasso	3	0.04	9.9e-06	-16.85	16.9	3.0e-64	-0.70	0.83	0.05	FALSE
83	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	INTS4	0.11	0.11	lasso	2	0.10	3.3e-07	-6.17	6.3	2.9e-10	-0.16	0.01	0.99	TRUE
84	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NARS2	0.11	0.01	enet	10	0.04	1.2e-03	-16.85	13.8	2.0e-43	-0.61	0.03	0.20	FALSE
85	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C11orf67	0.08	0.09	lasso	9	0.07	1.0e-03	5.36	-5.2	1.9e-07	0.03	0.06	0.13	FALSE
86	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INTS4	0.16	0.10	lasso	3	0.08	2.9e-04	-6.02	6.0	2.0e-09	-0.15	0.01	0.94	FALSE
87	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NARS2	0.20	0.21	lasso	9	0.20	5.6e-09	-16.77	16.8	1.2e-63	-0.69	0.62	0.37	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLNS1A	0.04	0.02	blup	41	0.03	3.0e-04	4.43	5.7	1.0e-08	-0.02	0.14	0.37	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAB2	0.06	0.06	blup	100	0.07	7.8e-08	-21.31	22.0	1.8e-107	-0.94	0.04	0.96	TRUE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	INTS4	0.17	0.15	lasso	6	0.17	3.3e-17	-6.02	7.1	1.2e-12	-0.12	0.01	0.99	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD21	0.03	0.00	blup	51	0.01	7.2e-02	-20.60	17.6	2.7e-69	-0.77	0.01	0.63	TRUE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	NARS2	0.30	0.19	lasso	2	0.17	2.6e-17	-16.84	16.8	1.2e-63	-0.70	1.00	0.00	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	USP35	0.12	0.02	blup	55	0.02	1.5e-03	-4.12	-10.8	3.8e-27	0.31	0.09	0.10	FALSE
94	The Cancer Genome Atlas	Soft Tissue Sarcoma	NARS2	0.11	0.05	enet	7	0.06	2.0e-04	-16.81	15.4	2.0e-53	-0.62	0.13	0.52	FALSE
95	The Cancer Genome Atlas	Stomach Adenocarcinoma	GAB2	0.04	0.04	blup	100	0.04	1.4e-03	-20.46	22.0	1.3e-107	-0.91	0.05	0.88	FALSE
96	The Cancer Genome Atlas	Stomach Adenocarcinoma	INTS4	0.12	0.10	lasso	4	0.09	3.2e-07	-6.17	6.1	8.8e-10	-0.15	0.01	0.99	FALSE
97	The Cancer Genome Atlas	Testicular Germ Cell Tumors	INTS4	0.20	0.03	blup	72	0.07	2.1e-03	-2.95	6.2	5.6e-10	-0.12	0.02	0.32	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf67	0.11	0.09	blup	60	0.12	7.8e-12	4.72	-5.9	3.7e-09	0.00	0.96	0.04	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	INTS4	0.20	0.20	enet	7	0.23	6.8e-22	-6.17	7.1	1.7e-12	-0.11	0.01	0.99	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	KCTD21	0.05	0.03	blup	51	0.03	1.2e-03	-3.91	16.2	1.1e-58	-0.56	0.06	0.39	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	NARS2	0.27	0.27	lasso	4	0.27	1.9e-26	-16.77	17.1	1.1e-65	-0.70	1.00	0.00	FALSE